Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptide lactyltransferase (CoA-dependent) activity	CREBBP EP300	7.67e-07	2	18	2	GO:0120300
GeneOntologyMolecularFunction	histone H3K27 acetyltransferase activity	CREBBP EP300	7.67e-07	2	18	2	GO:0044017
GeneOntologyMolecularFunction	histone H3K18 acetyltransferase activity	CREBBP EP300	2.30e-06	3	18	2	GO:0043993
GeneOntologyMolecularFunction	zinc ion binding	CXXC5 ERVK-5 KMT2A CREBBP HHIP EP300 CXXC4	7.10e-06	891	18	7	GO:0008270
GeneOntologyMolecularFunction	transition metal ion binding	CXXC5 ERVK-5 KMT2A CREBBP HHIP EP300 CXXC4	4.64e-05	1189	18	7	GO:0046914
GeneOntologyMolecularFunction	histone H3 acetyltransferase activity	CREBBP EP300	8.00e-05	15	18	2	GO:0010484
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	CXXC5 LMO1 KMT2A CREBBP EP300	1.29e-04	582	18	5	GO:0140297
GeneOntologyMolecularFunction	transcription coactivator activity	LMO1 CREBBP EP300 NOTCH1	1.34e-04	303	18	4	GO:0003713
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	CREBBP EP300	1.60e-04	21	18	2	GO:0042975
GeneOntologyMolecularFunction	methyl-CpG binding	CXXC5 CXXC4	3.51e-04	31	18	2	GO:0008327
GeneOntologyMolecularFunction	acetylation-dependent protein binding	KMT2A EP300	3.51e-04	31	18	2	GO:0140033
GeneOntologyMolecularFunction	chromatin binding	EGFR KMT2A CREBBP EP300 NOTCH1	3.93e-04	739	18	5	GO:0003682
GeneOntologyMolecularFunction	chromatin DNA binding	CREBBP EP300 NOTCH1	4.27e-04	167	18	3	GO:0031490
GeneOntologyMolecularFunction	transcription factor binding	CXXC5 LMO1 KMT2A CREBBP EP300	4.28e-04	753	18	5	GO:0008134
GeneOntologyMolecularFunction	bHLH transcription factor binding	CREBBP EP300	5.02e-04	37	18	2	GO:0043425
GeneOntologyMolecularFunction	histone acetyltransferase activity	CREBBP EP300	9.53e-04	51	18	2	GO:0004402
GeneOntologyMolecularFunction	transcription coactivator binding	CREBBP EP300	1.07e-03	54	18	2	GO:0001223
GeneOntologyMolecularFunction	histone modifying activity	KMT2A CREBBP EP300	1.07e-03	229	18	3	GO:0140993
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	CREBBP EP300	1.11e-03	55	18	2	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	CREBBP EP300	1.32e-03	60	18	2	GO:0034212
GeneOntologyMolecularFunction	transcription coregulator activity	LMO1 CREBBP EP300 NOTCH1	1.39e-03	562	18	4	GO:0003712
GeneOntologyMolecularFunction	p53 binding	CREBBP EP300	2.16e-03	77	18	2	GO:0002039
GeneOntologyMolecularFunction	N-acetyltransferase activity	CREBBP EP300	2.21e-03	78	18	2	GO:0008080
GeneOntologyMolecularFunction	damaged DNA binding	CREBBP EP300	2.56e-03	84	18	2	GO:0003684
GeneOntologyMolecularFunction	SMAD binding	CREBBP EP300	2.68e-03	86	18	2	GO:0046332
GeneOntologyMolecularFunction	N-acyltransferase activity	CREBBP EP300	3.75e-03	102	18	2	GO:0016410
GeneOntologyMolecularFunction	acetyltransferase activity	CREBBP EP300	3.89e-03	104	18	2	GO:0016407
GeneOntologyMolecularFunction	PDZ domain binding	NLGN1 CXXC4	5.40e-03	123	18	2	GO:0030165
GeneOntologyMolecularFunction	transcription coregulator binding	CREBBP EP300	6.94e-03	140	18	2	GO:0001221
GeneOntologyMolecularFunction	growth factor binding	EGFR CHRDL1	8.55e-03	156	18	2	GO:0019838
GeneOntologyMolecularFunction	modification-dependent protein binding	KMT2A EP300	1.45e-02	206	18	2	GO:0140030
GeneOntologyMolecularFunction	protein phosphatase binding	EGFR PPP1R3G	1.51e-02	210	18	2	GO:0019903
GeneOntologyMolecularFunction	cell adhesion molecule binding	EGFR RPL34 NLGN1	1.57e-02	599	18	3	GO:0050839
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	LMO1 CREBBP EP300 NOTCH1	1.80e-02	1160	18	4	GO:0030674
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	CREBBP EP300	1.91e-02	238	18	2	GO:0016747
GeneOntologyBiologicalProcess	pattern specification process	KMT2A CHRDL1 HHIP EP300 NOTCH1 WIF1 CXXC4	1.68e-07	526	18	7	GO:0007389
GeneOntologyBiologicalProcess	rhythmic process	EGFR KMT2A CREBBP EP300 NOTCH1 NLGN1	4.22e-07	360	18	6	GO:0048511
GeneOntologyBiologicalProcess	regionalization	KMT2A HHIP EP300 NOTCH1 WIF1 CXXC4	2.20e-06	478	18	6	GO:0003002
GeneOntologyBiologicalProcess	cellular response to growth factor stimulus	EGFR KMT2A CHRDL1 CREBBP HHIP EP300 NOTCH1	4.21e-06	850	18	7	GO:0071363
GeneOntologyBiologicalProcess	N-terminal peptidyl-lysine acetylation	CREBBP EP300	4.31e-06	4	18	2	GO:0018076
GeneOntologyBiologicalProcess	response to growth factor	EGFR KMT2A CHRDL1 CREBBP HHIP EP300 NOTCH1	5.41e-06	883	18	7	GO:0070848
GeneOntologyBiologicalProcess	regulation of cellular response to growth factor stimulus	CHRDL1 CREBBP HHIP EP300 NOTCH1	2.15e-05	412	18	5	GO:0090287
GeneOntologyBiologicalProcess	transforming growth factor beta receptor superfamily signaling pathway	CHRDL1 CREBBP EP300 NOTCH1 WIF1	3.10e-05	445	18	5	GO:0141091
GeneOntologyBiologicalProcess	enzyme-linked receptor protein signaling pathway	EGFR CHRDL1 CREBBP HHIP EP300 NOTCH1 WIF1	3.71e-05	1186	18	7	GO:0007167
GeneOntologyBiologicalProcess	viral process	EGFR ERVK-5 CREBBP EP300 NOTCH1	3.79e-05	464	18	5	GO:0016032
GeneOntologyBiologicalProcess	cell surface receptor protein serine/threonine kinase signaling pathway	CHRDL1 CREBBP EP300 NOTCH1 WIF1	4.55e-05	482	18	5	GO:0007178
GeneOntologyBiologicalProcess	anterior/posterior pattern specification	KMT2A EP300 NOTCH1 WIF1	5.38e-05	247	18	4	GO:0009952
GeneOntologyBiologicalProcess	circadian rhythm	EGFR KMT2A EP300 NLGN1	5.47e-05	248	18	4	GO:0007623
GeneOntologyBiologicalProcess	AMPA glutamate receptor clustering	CHRDL1 NLGN1	6.51e-05	14	18	2	GO:0097113
GeneOntologyBiologicalProcess	glutamate receptor clustering	CHRDL1 NLGN1	6.51e-05	14	18	2	GO:0097688
GeneOntologyBiologicalProcess	lung development	EGFR HHIP EP300 NOTCH1	7.50e-05	269	18	4	GO:0030324
GeneOntologyBiologicalProcess	respiratory tube development	EGFR HHIP EP300 NOTCH1	7.94e-05	273	18	4	GO:0030323
GeneOntologyBiologicalProcess	N-terminal protein amino acid acetylation	CREBBP EP300	8.57e-05	16	18	2	GO:0006474
GeneOntologyBiologicalProcess	regulation of cellular response to heat	CREBBP EP300	8.57e-05	16	18	2	GO:1900034
GeneOntologyBiologicalProcess	respiratory system development	EGFR HHIP EP300 NOTCH1	1.22e-04	305	18	4	GO:0060541
GeneOntologyBiologicalProcess	axis specification	CHRDL1 NOTCH1 CXXC4	1.23e-04	113	18	3	GO:0009798
GeneOntologyBiologicalProcess	embryo development	EGFR KMT2A CHRDL1 CREBBP EP300 NOTCH1 CXXC4	1.26e-04	1437	18	7	GO:0009790
GeneOntologyBiologicalProcess	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	CREBBP EP300 NOTCH1	1.30e-04	115	18	3	GO:0090100
GeneOntologyBiologicalProcess	response to heat	DNAJA4 CREBBP EP300	1.51e-04	121	18	3	GO:0009408
GeneOntologyBiologicalProcess	neurotransmitter-gated ion channel clustering	CHRDL1 NLGN1	1.64e-04	22	18	2	GO:0072578
GeneOntologyBiologicalProcess	stimulatory C-type lectin receptor signaling pathway	CREBBP EP300	1.80e-04	23	18	2	GO:0002223
GeneOntologyBiologicalProcess	regulation of cell adhesion molecule production	CREBBP NOTCH1	1.80e-04	23	18	2	GO:0060353
GeneOntologyBiologicalProcess	cellular response to lectin	CREBBP EP300	1.80e-04	23	18	2	GO:1990858
GeneOntologyBiologicalProcess	response to lectin	CREBBP EP300	1.80e-04	23	18	2	GO:1990840
GeneOntologyBiologicalProcess	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	CHRDL1 CREBBP EP300 NOTCH1	2.00e-04	347	18	4	GO:0090092
GeneOntologyBiologicalProcess	modulation of chemical synaptic transmission	EGFR KMT2A CHRDL1 NOTCH1 NLGN1	2.04e-04	663	18	5	GO:0050804
GeneOntologyBiologicalProcess	regulation of trans-synaptic signaling	EGFR KMT2A CHRDL1 NOTCH1 NLGN1	2.06e-04	664	18	5	GO:0099177
GeneOntologyBiologicalProcess	cell adhesion molecule production	CREBBP NOTCH1	2.31e-04	26	18	2	GO:0060352
GeneOntologyBiologicalProcess	regulation of Wnt signaling pathway	EGFR NOTCH1 WIF1 CXXC4	2.50e-04	368	18	4	GO:0030111
GeneOntologyBiologicalProcess	learning or memory	EGFR KMT2A CREBBP EP300	2.63e-04	373	18	4	GO:0007611
GeneOntologyBiologicalProcess	peptidyl-lysine acetylation	CREBBP EP300	2.68e-04	28	18	2	GO:0018394
GeneOntologyBiologicalProcess	N-terminal protein amino acid modification	CREBBP EP300	2.88e-04	29	18	2	GO:0031365
GeneOntologyBiologicalProcess	response to light stimulus	EGFR KMT2A CREBBP EP300	2.88e-04	382	18	4	GO:0009416
GeneOntologyBiologicalProcess	response to calcium ion	EGFR EP300 NLGN1	3.49e-04	161	18	3	GO:0051592
GeneOntologyBiologicalProcess	peptidyl-lysine modification	KMT2A CREBBP EP300	3.56e-04	162	18	3	GO:0018205
GeneOntologyBiologicalProcess	response to UV	EGFR CREBBP EP300	3.89e-04	167	18	3	GO:0009411
GeneOntologyBiologicalProcess	response to metal ion	EGFR KMT2A EP300 NLGN1	3.95e-04	415	18	4	GO:0010038
GeneOntologyBiologicalProcess	regulation of generation of precursor metabolites and energy	CXXC5 EP300 PPP1R3G	4.03e-04	169	18	3	GO:0043467
GeneOntologyBiologicalProcess	positive regulation of nervous system development	EGFR EP300 NOTCH1 NLGN1	4.06e-04	418	18	4	GO:0051962
GeneOntologyBiologicalProcess	positive regulation of cellular response to transforming growth factor beta stimulus	CREBBP EP300	4.21e-04	35	18	2	GO:1903846
GeneOntologyBiologicalProcess	positive regulation of transforming growth factor beta receptor signaling pathway	CREBBP EP300	4.21e-04	35	18	2	GO:0030511
GeneOntologyBiologicalProcess	cognition	EGFR KMT2A CREBBP EP300	4.25e-04	423	18	4	GO:0050890
GeneOntologyBiologicalProcess	face morphogenesis	CREBBP EP300	5.78e-04	41	18	2	GO:0060325
GeneOntologyBiologicalProcess	positive regulation of intracellular signal transduction	CXXC5 EGFR CREBBP EP300 NOTCH1 NLGN1	5.93e-04	1299	18	6	GO:1902533
GeneOntologyBiologicalProcess	negative regulation of Wnt signaling pathway	NOTCH1 WIF1 CXXC4	6.11e-04	195	18	3	GO:0030178
GeneOntologyBiologicalProcess	positive regulation of synaptic transmission, glutamatergic	EGFR NLGN1	6.36e-04	43	18	2	GO:0051968
GeneOntologyBiologicalProcess	negative regulation of cellular component organization	KMT2A DNAJA4 EP300 NOTCH1 NLGN1	6.92e-04	864	18	5	GO:0051129
GeneOntologyBiologicalProcess	response to temperature stimulus	DNAJA4 CREBBP EP300	7.38e-04	208	18	3	GO:0009266
GeneOntologyBiologicalProcess	response to abiotic stimulus	EGFR KMT2A DNAJA4 CREBBP EP300 NOTCH1	7.60e-04	1361	18	6	GO:0009628
GeneOntologyBiologicalProcess	head morphogenesis	CREBBP EP300	7.92e-04	48	18	2	GO:0060323
GeneOntologyBiologicalProcess	behavior	EGFR KMT2A CREBBP EP300 NLGN1	7.96e-04	891	18	5	GO:0007610
GeneOntologyBiologicalProcess	response to radiation	EGFR KMT2A CREBBP EP300	8.15e-04	503	18	4	GO:0009314
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	LMO1 EGFR KMT2A CREBBP EP300 NOTCH1	8.50e-04	1390	18	6	GO:0045944
GeneOntologyBiologicalProcess	synapse maturation	CHRDL1 NLGN1	8.60e-04	50	18	2	GO:0060074
GeneOntologyBiologicalProcess	cardiocyte differentiation	EGFR EP300 NOTCH1	8.79e-04	221	18	3	GO:0035051
GeneOntologyBiologicalProcess	homeostasis of number of cells within a tissue	KMT2A NOTCH1	8.94e-04	51	18	2	GO:0048873
GeneOntologyBiologicalProcess	Wnt signaling pathway	EGFR NOTCH1 WIF1 CXXC4	8.96e-04	516	18	4	GO:0016055
GeneOntologyBiologicalProcess	embryonic axis specification	CHRDL1 CXXC4	9.29e-04	52	18	2	GO:0000578
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	EGFR KMT2A CHRDL1 NOTCH1 NLGN1	9.71e-04	931	18	5	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	EGFR KMT2A CHRDL1 NOTCH1 NLGN1	9.71e-04	931	18	5	GO:0007268
GeneOntologyBiologicalProcess	trans-synaptic signaling	EGFR KMT2A CHRDL1 NOTCH1 NLGN1	1.01e-03	939	18	5	GO:0099537
GeneOntologyBiologicalProcess	response to dexamethasone	EGFR EP300	1.04e-03	55	18	2	GO:0071548
GeneOntologyBiologicalProcess	protein destabilization	CREBBP EP300	1.08e-03	56	18	2	GO:0031648
GeneOntologyBiologicalProcess	regulation of neurotransmitter receptor activity	NOTCH1 NLGN1	1.08e-03	56	18	2	GO:0099601
GeneOntologyBiologicalProcess	postsynaptic membrane organization	CHRDL1 NLGN1	1.08e-03	56	18	2	GO:0001941
GeneOntologyBiologicalProcess	positive regulation of cardiac muscle tissue growth	EP300 NOTCH1	1.08e-03	56	18	2	GO:0055023
GeneOntologyBiologicalProcess	viral transcription	EP300 NOTCH1	1.16e-03	58	18	2	GO:0019083
GeneOntologyBiologicalProcess	positive regulation of receptor signaling pathway via JAK-STAT	EP300 NOTCH1	1.16e-03	58	18	2	GO:0046427
GeneOntologyBiologicalProcess	digestive tract morphogenesis	EGFR NOTCH1	1.19e-03	59	18	2	GO:0048546
GeneOntologyBiologicalProcess	synaptic signaling	EGFR KMT2A CHRDL1 NOTCH1 NLGN1	1.20e-03	976	18	5	GO:0099536
GeneOntologyBiologicalProcess	positive regulation of heart growth	EP300 NOTCH1	1.24e-03	60	18	2	GO:0060421
GeneOntologyBiologicalProcess	regulation of glial cell proliferation	EGFR NOTCH1	1.32e-03	62	18	2	GO:0060251
GeneOntologyBiologicalProcess	face development	CREBBP EP300	1.36e-03	63	18	2	GO:0060324
GeneOntologyBiologicalProcess	T-helper 17 type immune response	EP300 NOTCH1	1.40e-03	64	18	2	GO:0072538
GeneOntologyBiologicalProcess	positive regulation of G1/S transition of mitotic cell cycle	EGFR CREBBP	1.40e-03	64	18	2	GO:1900087
GeneOntologyBiologicalProcess	body morphogenesis	CREBBP EP300	1.40e-03	64	18	2	GO:0010171
GeneOntologyBiologicalProcess	transcription initiation-coupled chromatin remodeling	KMT2A EP300	1.45e-03	65	18	2	GO:0045815
GeneOntologyBiologicalProcess	regulation of collagen biosynthetic process	EP300 NOTCH1	1.45e-03	65	18	2	GO:0032965
GeneOntologyBiologicalProcess	positive regulation of receptor signaling pathway via STAT	EP300 NOTCH1	1.45e-03	65	18	2	GO:1904894
GeneOntologyBiologicalProcess	positive regulation of protein localization	EGFR CREBBP EP300 NLGN1	1.48e-03	591	18	4	GO:1903829
GeneOntologyBiologicalProcess	positive regulation of gene expression, epigenetic	KMT2A EP300	1.58e-03	68	18	2	GO:0141137
GeneOntologyBiologicalProcess	protein acetylation	CREBBP EP300	1.58e-03	68	18	2	GO:0006473
GeneOntologyBiologicalProcess	positive regulation of dendritic spine development	CREBBP NLGN1	1.68e-03	70	18	2	GO:0060999
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	CXXC5 LMO1 CREBBP EP300 NOTCH1	1.68e-03	1053	18	5	GO:0000122
HumanPheno	Aortic isthmus hypoplasia	CREBBP EP300	2.16e-06	2	8	2	HP:0034227
HumanPheno	Plantar crease between first and second toes	CREBBP EP300	2.16e-06	2	8	2	HP:0008107
HumanPheno	High axial triradius	CREBBP EP300	2.16e-06	2	8	2	HP:0001042
HumanPheno	Humoral immunodeficiency	CREBBP EP300	6.47e-06	3	8	2	HP:0005363
HumanPheno	Prominent nasal septum	CREBBP EP300	6.47e-06	3	8	2	HP:0005322
HumanPheno	Radial deviation of thumb terminal phalanx	CREBBP EP300	6.47e-06	3	8	2	HP:0005895
HumanPheno	Laryngeal cartilage malformation	CREBBP EP300	6.47e-06	3	8	2	HP:0008752
HumanPheno	Phobia	CREBBP EP300	6.47e-06	3	8	2	HP:5200232
HumanPheno	Agoraphobia	CREBBP EP300	6.47e-06	3	8	2	HP:0000756
HumanPheno	Short columella	KMT2A CREBBP EP300	9.12e-06	29	8	3	HP:0002000
HumanPheno	Broad eyebrow	KMT2A CREBBP EP300	9.12e-06	29	8	3	HP:0011229
HumanPheno	Trichiasis	CREBBP EP300	1.29e-05	4	8	2	HP:0001128
HumanPheno	Widened distal phalanges	CREBBP EP300	1.29e-05	4	8	2	HP:0006200
HumanPheno	Visceral hemangioma	CREBBP EP300	1.29e-05	4	8	2	HP:0410266
HumanPheno	Talon cusp	CREBBP EP300	1.29e-05	4	8	2	HP:0011087
HumanPheno	Vascular ring	CREBBP EP300	1.29e-05	4	8	2	HP:0010775
HumanPheno	Hepatic hemangioma	CREBBP EP300	1.29e-05	4	8	2	HP:0031207
HumanPheno	Papillary cystadenoma of the epididymis	CREBBP EP300	2.15e-05	5	8	2	HP:0009715
HumanPheno	Supernumerary cusp	CREBBP EP300	2.15e-05	5	8	2	HP:0033777
HumanPheno	Epididymal neoplasm	CREBBP EP300	2.15e-05	5	8	2	HP:0030421
HumanPheno	Long eyelashes	EGFR KMT2A CREBBP EP300	2.54e-05	129	8	4	HP:0000527
HumanPheno	Large foramen magnum	CREBBP EP300	3.23e-05	6	8	2	HP:0002700
HumanPheno	Spinal cord compression	LMO1 CREBBP EP300	3.27e-05	44	8	3	HP:0002176
HumanPheno	Prominent digit pad	KMT2A CREBBP EP300	4.26e-05	48	8	3	HP:0011298
HumanPheno	Deviated nasal septum	CREBBP EP300	4.52e-05	7	8	2	HP:0004411
HumanPheno	Hypoplastic left heart	CREBBP EP300 NOTCH1	4.53e-05	49	8	3	HP:0004383
HumanPheno	Coarctation of aorta	EGFR CREBBP EP300 NOTCH1	4.61e-05	150	8	4	HP:0001680
HumanPheno	Congenital malformation of the left heart	CREBBP EP300 NOTCH1	5.11e-05	51	8	3	HP:0045017
HumanPheno	Hypoplastic heart	CREBBP EP300 NOTCH1	6.08e-05	54	8	3	HP:0001961
HumanPheno	Pilomatrixoma	CREBBP EP300	7.73e-05	9	8	2	HP:0030434
HumanPheno	Cervical cord compression	CREBBP EP300	7.73e-05	9	8	2	HP:0002341
HumanPheno	Frontal hirsutism	CREBBP EP300	9.65e-05	10	8	2	HP:0011335
HumanPheno	Abnormal subclavian artery morphology	CREBBP EP300	1.18e-04	11	8	2	HP:0031251
HumanPheno	Facial grimacing	CREBBP EP300	1.67e-04	13	8	2	HP:0000273
HumanPheno	Keloids	CREBBP EP300	1.67e-04	13	8	2	HP:0010562
HumanPheno	Parietal foramina	CREBBP EP300	1.95e-04	14	8	2	HP:0002697
HumanPheno	Duplication of phalanx of hallux	CREBBP EP300	1.95e-04	14	8	2	HP:0010066
HumanPheno	Hypoplastic aortic arch	CREBBP EP300	1.95e-04	14	8	2	HP:0012304
HumanPheno	Social and occupational deterioration	CREBBP EP300	2.24e-04	15	8	2	HP:0007086
HumanPheno	Duplication of phalanx of toe	CREBBP EP300	2.24e-04	15	8	2	HP:0010181
HumanPheno	Square face	CREBBP EP300	2.56e-04	16	8	2	HP:0000321
HumanPheno	Premature thelarche	CREBBP EP300	2.90e-04	17	8	2	HP:0010314
HumanPheno	Facial hirsutism	CREBBP EP300	3.26e-04	18	8	2	HP:0009937
HumanPheno	Skin appendage neoplasm	CREBBP EP300	3.26e-04	18	8	2	HP:0012842
HumanPheno	Abnormal columella morphology	KMT2A CREBBP EP300	3.50e-04	97	8	3	HP:0009929
HumanPheno	Absent earlobe	CREBBP EP300	4.04e-04	20	8	2	HP:0000387
HumanPheno	Localized hirsutism	CREBBP EP300	4.47e-04	21	8	2	HP:0009889
HumanPheno	Deep plantar creases	CREBBP EP300	4.47e-04	21	8	2	HP:0001869
HumanPheno	Corneal scarring	CREBBP EP300	4.47e-04	21	8	2	HP:0000559
HumanPheno	Flat face	KMT2A CREBBP EP300	4.55e-04	106	8	3	HP:0012368
HumanPheno	Abnormal aortic arch morphology	CREBBP EP300 NOTCH1	4.94e-04	109	8	3	HP:0012303
HumanPheno	Abnormal foramen magnum morphology	CREBBP EP300	5.37e-04	23	8	2	HP:0002699
HumanPheno	Agenesis of permanent teeth	CREBBP EP300	5.37e-04	23	8	2	HP:0006349
HumanPheno	Aortic valve stenosis	CREBBP EP300 NOTCH1	5.49e-04	113	8	3	HP:0001650
HumanPheno	Abnormal eyelash morphology	EGFR KMT2A CREBBP EP300	5.54e-04	284	8	4	HP:0000499
HumanPheno	Abnormal nasal septum morphology	KMT2A CREBBP EP300	5.78e-04	115	8	3	HP:0000419
HumanPheno	Simple ear	CREBBP EP300	5.86e-04	24	8	2	HP:0020206
HumanPheno	Broad hallux phalanx	CREBBP EP300	5.86e-04	24	8	2	HP:0010059
HumanPheno	Localized skin lesion	LMO1 EGFR KMT2A CREBBP EP300 NOTCH1	5.95e-04	897	8	6	HP:0011355
HumanPheno	Low posterior hairline	KMT2A CREBBP EP300	6.08e-04	117	8	3	HP:0002162
HumanPheno	Abnormality of the posterior hairline	KMT2A CREBBP EP300	6.08e-04	117	8	3	HP:0030141
HumanPheno	Shawl scrotum	CREBBP EP300	6.36e-04	25	8	2	HP:0000049
HumanPheno	Bicuspid aortic valve	CREBBP EP300 NOTCH1	6.39e-04	119	8	3	HP:0001647
HumanPheno	Abnormal aortic valve cusp morphology	CREBBP EP300 NOTCH1	6.71e-04	121	8	3	HP:0031567
HumanPheno	Short palpebral fissure	KMT2A CREBBP EP300	6.87e-04	122	8	3	HP:0012745
HumanPheno	Minor feet anomalies	CREBBP EP300	6.88e-04	26	8	2	HP:0010613
HumanPheno	Abnormal feet morphology	CREBBP EP300	6.88e-04	26	8	2	HP:0010611
HumanPheno	Phonophobia	CREBBP EP300	6.88e-04	26	8	2	HP:0002183
HumanPheno	Perimembranous ventricular septal defect	CREBBP EP300	6.88e-04	26	8	2	HP:0011682
HumanPheno	Short phalanx of finger	KMT2A CREBBP EP300 NOTCH1	7.37e-04	306	8	4	HP:0009803
HumanPheno	Miosis	LMO1 CHRDL1	7.43e-04	27	8	2	HP:0000616
HumanPheno	Flared iliac wing	CREBBP EP300	7.43e-04	27	8	2	HP:0002869
HumanPheno	Broad distal phalanx of finger	CREBBP EP300	7.43e-04	27	8	2	HP:0009836
HumanPheno	Blepharophimosis	KMT2A CREBBP EP300	8.10e-04	129	8	3	HP:0000581
HumanPheno	Abnormal parietal bone morphology	CREBBP EP300	8.58e-04	29	8	2	HP:0002696
HumanPheno	Aplasia/Hypoplasia of the phalanges of the hand	KMT2A CREBBP EP300 NOTCH1	8.64e-04	319	8	4	HP:0009767
HumanPheno	Avascular necrosis of the capital femoral epiphysis	CREBBP EP300	9.19e-04	30	8	2	HP:0005743
HumanPheno	Abnormal epididymis morphology	CREBBP EP300	9.19e-04	30	8	2	HP:0009714
HumanPheno	Preaxial foot polydactyly	CREBBP EP300	9.19e-04	30	8	2	HP:0001841
HumanPheno	Patent foramen ovale	CREBBP EP300 NOTCH1	9.25e-04	135	8	3	HP:0001655
HumanPheno	Short finger	KMT2A CREBBP EP300 NOTCH1	9.27e-04	325	8	4	HP:0009381
HumanPheno	Hypoplastic iliac wing	CREBBP EP300	9.81e-04	31	8	2	HP:0002866
HumanPheno	Pulmonic stenosis	CREBBP EP300 NOTCH1	9.86e-04	138	8	3	HP:0001642
HumanPheno	Aplasia/Hypoplasia of toe	KMT2A EP300 NOTCH1	1.03e-03	140	8	3	HP:0001991
HumanPheno	Frontal upsweep of hair	CREBBP EP300	1.11e-03	33	8	2	HP:0002236
HumanPheno	Syringomyelia	CREBBP EP300	1.11e-03	33	8	2	HP:0003396
HumanPheno	Abnormal branching pattern of the aortic arch	CREBBP EP300	1.11e-03	33	8	2	HP:0011587
HumanPheno	Abnormal mitral valve morphology	CREBBP EP300 NOTCH1	1.16e-03	146	8	3	HP:0031477
HumanPheno	Aspiration	CREBBP EP300	1.18e-03	34	8	2	HP:0002835
HumanPheno	Abnormal number of permanent teeth	CREBBP EP300	1.25e-03	35	8	2	HP:0011044
HumanPheno	Hemangioma	CREBBP EP300 NOTCH1	1.28e-03	151	8	3	HP:0001028
HumanPheno	Hydrocele testis	CREBBP EP300	1.32e-03	36	8	2	HP:0000034
HumanPheno	Disturbance of facial expression	CREBBP EP300	1.32e-03	36	8	2	HP:0005324
HumanPheno	Abnormality of the distal phalanx of the thumb	CREBBP EP300	1.32e-03	36	8	2	HP:0009617
HumanPheno	Nasolacrimal duct obstruction	CREBBP EP300	1.32e-03	36	8	2	HP:0000579
HumanPheno	Thick eyebrow	KMT2A CREBBP EP300	1.36e-03	154	8	3	HP:0000574
HumanPheno	Vascular neoplasm	CREBBP EP300 NOTCH1	1.38e-03	155	8	3	HP:0100742
HumanPheno	Auditory sensitivity	CREBBP EP300	1.40e-03	37	8	2	HP:0025112
HumanPheno	Accessory spleen	CREBBP EP300	1.40e-03	37	8	2	HP:0001747
HumanPheno	Auditory hypersensitivity	CREBBP EP300	1.40e-03	37	8	2	HP:5200060
MousePheno	abnormal vasculogenesis	CREBBP EP300 NOTCH1	1.92e-05	54	14	3	MP:0001622
MousePheno	calcified aortic valve	EGFR NOTCH1	1.95e-05	7	14	2	MP:0006116
MousePheno	abnormal placenta labyrinth size	CXXC5 EGFR CXXC4	2.65e-05	60	14	3	MP:0011519
MousePheno	pointed snout	EGFR KMT2A	4.17e-05	10	14	2	MP:0000448
MousePheno	ventricle myocardium hypoplasia	CREBBP EP300 NOTCH1	4.39e-05	71	14	3	MP:0010502
MousePheno	abnormal placenta junctional zone morphology	CXXC5 EGFR CXXC4	6.28e-05	80	14	3	MP:0008957
MousePheno	myocardium hypoplasia	CREBBP EP300 NOTCH1	7.79e-05	86	14	3	MP:0010500
MousePheno	enhanced osteoblast differentiation	CXXC5 EGFR	9.71e-05	15	14	2	MP:0011710
MousePheno	disorganized pancreatic islets	EGFR HHIP	1.11e-04	16	14	2	MP:0009254
MousePheno	ventricular hypoplasia	CREBBP EP300 NOTCH1	1.19e-04	99	14	3	MP:0000279
MousePheno	heart hypoplasia	CREBBP EP300 NOTCH1	1.33e-04	103	14	3	MP:0002740
MousePheno	abnormal extraembryonic tissue morphology	CXXC5 EGFR CREBBP EP300 NOTCH1 CXXC4	1.41e-04	908	14	6	MP:0002086
MousePheno	thin ventricle myocardium compact layer	CREBBP EP300	1.75e-04	20	14	2	MP:0010556
MousePheno	anemia	KMT2A CREBBP EP300 NOTCH1	1.89e-04	306	14	4	MP:0001577
MousePheno	abnormal ventricle myocardium morphology	CREBBP EP300 NOTCH1	1.90e-04	116	14	3	MP:0010499
MousePheno	decreased thymocyte number	CREBBP EP300 NOTCH1	2.48e-04	127	14	3	MP:0000715
MousePheno	rough coat	EGFR KMT2A	2.54e-04	24	14	2	MP:0010179
MousePheno	abnormal lung interstitium morphology	EGFR CREBBP	3.22e-04	27	14	2	MP:0002276
MousePheno	thick aortic valve	EGFR NOTCH1	3.22e-04	27	14	2	MP:0010594
MousePheno	small snout	EGFR KMT2A CREBBP	3.59e-04	144	14	3	MP:0030190
MousePheno	abnormal heart valve physiology	EGFR NOTCH1	3.99e-04	30	14	2	MP:0011926
MousePheno	thick semilunar valve	EGFR NOTCH1	3.99e-04	30	14	2	MP:0031584
MousePheno	embryonic lethality during organogenesis, complete penetrance	EGFR KMT2A CREBBP EP300 NOTCH1	4.26e-04	700	14	5	MP:0011098
MousePheno	increased classified tumor incidence	KMT2A CREBBP NOTCH1 WIF1	4.38e-04	381	14	4	MP:0010273
MousePheno	abnormal classified tumor incidence	KMT2A CREBBP NOTCH1 WIF1	4.51e-04	384	14	4	MP:0020188
MousePheno	abnormal heart valve morphology	EGFR EP300 NOTCH1	5.15e-04	163	14	3	MP:0000285
MousePheno	respiratory failure	EGFR HHIP EP300	5.34e-04	165	14	3	MP:0001953
MousePheno	decreased aggression towards mice	CREBBP NLGN1	5.75e-04	36	14	2	MP:0003863
MousePheno	decreased respiration	EGFR HHIP EP300	5.83e-04	170	14	3	MP:0014274
MousePheno	abnormal myocardium layer morphology	EGFR CREBBP EP300 NOTCH1	5.99e-04	414	14	4	MP:0005329
MousePheno	abnormal heart layer morphology	EGFR CREBBP EP300 NOTCH1	6.44e-04	422	14	4	MP:0010545
MousePheno	increased leukemia incidence	KMT2A CREBBP	6.76e-04	39	14	2	MP:0002026
MousePheno	lethality throughout fetal growth and development	EGFR KMT2A CREBBP EP300	7.22e-04	435	14	4	MP:0006208
MousePheno	abnormal skeleton development	CXXC5 EGFR KMT2A CREBBP	8.00e-04	447	14	4	MP:0002113
MousePheno	abnormal pancreatic islet morphology	EGFR CREBBP HHIP	8.06e-04	190	14	3	MP:0005215
MousePheno	abnormal endocrine pancreas morphology	EGFR CREBBP HHIP	8.18e-04	191	14	3	MP:0009165
MousePheno	abnormal placenta labyrinth morphology	CXXC5 EGFR CXXC4	8.56e-04	194	14	3	MP:0001716
MousePheno	increased megakaryocyte cell number	CREBBP EP300	9.00e-04	45	14	2	MP:0008254
MousePheno	thin myocardium compact layer	CREBBP EP300	9.40e-04	46	14	2	MP:0004057
MousePheno	decreased common myeloid progenitor cell number	KMT2A CREBBP	9.81e-04	47	14	2	MP:0008813
MousePheno	abnormal blood circulation	EGFR KMT2A CREBBP EP300 NOTCH1	1.01e-03	845	14	5	MP:0002128
MousePheno	lethality throughout fetal growth and development, incomplete penetrance	EGFR CREBBP EP300	1.05e-03	208	14	3	MP:0011109
MousePheno	abnormal cardiac muscle tissue morphology	EGFR CREBBP EP300 NOTCH1	1.12e-03	489	14	4	MP:0010630
MousePheno	embryonic lethality during organogenesis	EGFR KMT2A CREBBP EP300 NOTCH1	1.19e-03	876	14	5	MP:0006207
MousePheno	abnormal myogenesis	KMT2A EP300	1.20e-03	52	14	2	MP:0000729
MousePheno	decreased aggression	CREBBP NLGN1	1.25e-03	53	14	2	MP:0005656
MousePheno	abnormal sensory ganglion morphology	EGFR KMT2A NOTCH1	1.25e-03	221	14	3	MP:0000960
MousePheno	craniofacial phenotype	CXXC5 EGFR KMT2A CREBBP EP300 NOTCH1	1.33e-03	1372	14	6	MP:0005382
MousePheno	abnormal craniofacial morphology	CXXC5 EGFR KMT2A CREBBP EP300 NOTCH1	1.33e-03	1372	14	6	MP:0000428
MousePheno	facial bone hypoplasia	EGFR CREBBP	1.44e-03	57	14	2	MP:0030386
MousePheno	kinked neural tube	EP300 NOTCH1	1.44e-03	57	14	2	MP:0003400
MousePheno	decreased hematopoietic stem cell number	KMT2A CREBBP	1.44e-03	57	14	2	MP:0004810
MousePheno	abnormal placenta morphology	CXXC5 EGFR NOTCH1 CXXC4	1.46e-03	525	14	4	MP:0001711
MousePheno	abnormal vitelline vasculature morphology	CREBBP EP300 NOTCH1	1.49e-03	235	14	3	MP:0003229
MousePheno	increased tumor incidence	KMT2A CREBBP NOTCH1 WIF1	1.51e-03	530	14	4	MP:0002020
MousePheno	increased malignant tumor incidence	KMT2A CREBBP WIF1	1.53e-03	237	14	3	MP:0002018
MousePheno	abnormal osteoblast differentiation	CXXC5 EGFR	1.65e-03	61	14	2	MP:0008395
MousePheno	abnormal hair texture	EGFR KMT2A	1.76e-03	63	14	2	MP:0002074
MousePheno	abnormal pulmonary alveolus morphology	EGFR CREBBP HHIP	1.88e-03	255	14	3	MP:0002270
MousePheno	abnormal rib morphology	CXXC5 KMT2A CREBBP	1.92e-03	257	14	3	MP:0000150
MousePheno	abnormal snout morphology	EGFR KMT2A CREBBP	1.92e-03	257	14	3	MP:0000443
MousePheno	abnormal myocardium compact layer morphology	CREBBP EP300	1.98e-03	67	14	2	MP:0004056
MousePheno	absent vitelline blood vessels	CREBBP NOTCH1	1.98e-03	67	14	2	MP:0001719
MousePheno	early cellular replicative senescence	KMT2A EP300	2.16e-03	70	14	2	MP:0008008
MousePheno	embryonic lethality during organogenesis, incomplete penetrance	EGFR CREBBP EP300	2.17e-03	268	14	3	MP:0011108
MousePheno	abnormal fibroblast physiology	EGFR KMT2A EP300	2.24e-03	271	14	3	MP:0020414
MousePheno	abnormal neural tube morphology	CREBBP HHIP EP300 NOTCH1	2.26e-03	591	14	4	MP:0002151
MousePheno	abnormal aortic valve morphology	EGFR NOTCH1	2.29e-03	72	14	2	MP:0002747
MousePheno	abnormal heart left ventricle outflow tract morphology	EGFR NOTCH1	2.29e-03	72	14	2	MP:0010429
MousePheno	abnormal aggression towards conspecific	CREBBP NLGN1	2.35e-03	73	14	2	MP:0021115
MousePheno	abnormal gas homeostasis	EGFR CREBBP EP300 PPP1R3G	2.38e-03	600	14	4	MP:0003948
MousePheno	abnormal pulmonary acinus morphology	EGFR CREBBP HHIP	2.56e-03	284	14	3	MP:0010911
MousePheno	abnormal trabecula carnea morphology	EP300 NOTCH1	2.68e-03	78	14	2	MP:0004067
MousePheno	abnormal cellular replicative senescence	KMT2A EP300	2.81e-03	80	14	2	MP:0008007
MousePheno	abnormal pulmonary alveolar system morphology	EGFR CREBBP HHIP	2.88e-03	296	14	3	MP:0010899
MousePheno	abnormal liver glycogen level	CREBBP PPP1R3G	2.88e-03	81	14	2	MP:0012777
MousePheno	abnormal tumor incidence	KMT2A CREBBP NOTCH1 WIF1	2.93e-03	635	14	4	MP:0002019
MousePheno	abnormal pectoral girdle bone morphology	CXXC5 KMT2A CREBBP	3.02e-03	301	14	3	MP:0004508
MousePheno	decreased angiogenesis	CREBBP NOTCH1	3.10e-03	84	14	2	MP:0005602
MousePheno	abnormal tumor susceptibility	KMT2A CREBBP NOTCH1 WIF1	3.19e-03	650	14	4	MP:0002166
MousePheno	abnormal megakaryocyte morphology	CREBBP EP300	3.24e-03	86	14	2	MP:0002417
MousePheno	abnormal muscle development	KMT2A EP300	3.32e-03	87	14	2	MP:0000733
MousePheno	decreased embryo size	EGFR CREBBP EP300 NOTCH1	3.35e-03	659	14	4	MP:0001698
MousePheno	abnormal muscle morphology	EGFR KMT2A CREBBP EP300 NOTCH1	3.36e-03	1106	14	5	MP:0002108
MousePheno	atrial septal defect	CREBBP EP300	3.39e-03	88	14	2	MP:0010403
MousePheno	hemorrhage	KMT2A CREBBP EP300 NOTCH1	3.45e-03	664	14	4	MP:0001914
MousePheno	abnormal embryonic tissue morphology	KMT2A CREBBP HHIP EP300 NOTCH1	3.49e-03	1116	14	5	MP:0002085
Domain	zf-CXXC	CXXC5 KMT2A CXXC4	1.23e-07	11	18	3	PF02008
Domain	Znf_CXXC	CXXC5 KMT2A CXXC4	1.23e-07	11	18	3	IPR002857
Domain	ZF_CXXC	CXXC5 KMT2A CXXC4	1.23e-07	11	18	3	PS51058
Domain	-	CREBBP EP300	8.77e-07	2	18	2	1.10.246.20
Domain	zf-TAZ	CREBBP EP300	8.77e-07	2	18	2	PF02135
Domain	ZF_TAZ	CREBBP EP300	8.77e-07	2	18	2	PS50134
Domain	Nuc_rcpt_coact_CREBbp	CREBBP EP300	8.77e-07	2	18	2	IPR014744
Domain	HAT_KAT11	CREBBP EP300	8.77e-07	2	18	2	PF08214
Domain	KIX	CREBBP EP300	8.77e-07	2	18	2	PS50952
Domain	ZnF_TAZ	CREBBP EP300	8.77e-07	2	18	2	SM00551
Domain	CBP_P300_HAT	CREBBP EP300	8.77e-07	2	18	2	IPR031162
Domain	Histone_AcTrfase_Rtt109/CBP	CREBBP EP300	8.77e-07	2	18	2	IPR013178
Domain	DUF902	CREBBP EP300	8.77e-07	2	18	2	PF06001
Domain	-	CREBBP EP300	8.77e-07	2	18	2	1.20.1020.10
Domain	RING_CBP-p300	CREBBP EP300	8.77e-07	2	18	2	IPR010303
Domain	KAT11	CREBBP EP300	8.77e-07	2	18	2	SM01250
Domain	-	CREBBP EP300	8.77e-07	2	18	2	1.10.1630.10
Domain	Znf_TAZ	CREBBP EP300	8.77e-07	2	18	2	IPR000197
Domain	KIX_dom	CREBBP EP300	8.77e-07	2	18	2	IPR003101
Domain	Creb_binding	CREBBP EP300	8.77e-07	2	18	2	PF09030
Domain	KIX	CREBBP EP300	8.77e-07	2	18	2	PF02172
Domain	CBP_P300_HAT	CREBBP EP300	8.77e-07	2	18	2	PS51727
Domain	BROMODOMAIN_2	KMT2A CREBBP EP300	7.83e-06	41	18	3	PS50014
Domain	BROMO	KMT2A CREBBP EP300	8.43e-06	42	18	3	SM00297
Domain	Bromodomain	KMT2A CREBBP EP300	8.43e-06	42	18	3	IPR001487
Domain	-	KMT2A CREBBP EP300	8.43e-06	42	18	3	1.20.920.10
Domain	Nuc_rcpt_coact	CREBBP EP300	1.31e-05	6	18	2	IPR009110
Domain	EGF_extracell	HHIP NOTCH1 WIF1	2.49e-05	60	18	3	IPR013111
Domain	EGF_2	HHIP NOTCH1 WIF1	2.49e-05	60	18	3	PF07974
Domain	ZF_ZZ_2	CREBBP EP300	1.33e-04	18	18	2	PS50135
Domain	ZF_ZZ_1	CREBBP EP300	1.33e-04	18	18	2	PS01357
Domain	ZZ	CREBBP EP300	1.33e-04	18	18	2	PF00569
Domain	Znf_ZZ	CREBBP EP300	1.49e-04	19	18	2	IPR000433
Domain	ZnF_ZZ	CREBBP EP300	1.49e-04	19	18	2	SM00291
Domain	Bromodomain_CS	CREBBP EP300	2.81e-04	26	18	2	IPR018359
Domain	hEGF	NOTCH1 WIF1	3.27e-04	28	18	2	PF12661
Domain	BROMODOMAIN_1	CREBBP EP300	5.73e-04	37	18	2	PS00633
Domain	Bromodomain	CREBBP EP300	6.04e-04	38	18	2	PF00439
Domain	EGF_3	HHIP NOTCH1 WIF1	1.40e-03	235	18	3	PS50026
Domain	EGF	HHIP NOTCH1 WIF1	1.40e-03	235	18	3	SM00181
Domain	EGF-like_dom	HHIP NOTCH1 WIF1	1.65e-03	249	18	3	IPR000742
Domain	EGF_1	HHIP NOTCH1 WIF1	1.76e-03	255	18	3	PS00022
Domain	EGF-like_CS	HHIP NOTCH1 WIF1	1.88e-03	261	18	3	IPR013032
Domain	EGF_2	HHIP NOTCH1 WIF1	1.97e-03	265	18	3	PS01186
Domain	EGF	NOTCH1 WIF1	6.44e-03	126	18	2	PF00008
Pathway	REACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION	CREBBP EP300 NOTCH1	8.13e-08	8	17	3	M48024
Pathway	REACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES	CREBBP EP300 NOTCH1	2.39e-07	11	17	3	M48021
Pathway	REACTOME_SIGNALING_BY_NOTCH3	EGFR CREBBP EP300 NOTCH1	2.97e-07	49	17	4	M618
Pathway	REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING	CREBBP EP300 NOTCH1	5.26e-07	14	17	3	M27808
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS	CREBBP EP300 NOTCH1	8.08e-07	16	17	3	M27121
Pathway	REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	CREBBP EP300 NOTCH1	1.64e-06	20	17	3	M27881
Pathway	REACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	CREBBP EP300 NOTCH1	3.30e-06	25	17	3	M27880
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS	EGFR CREBBP EP300	1.20e-05	38	17	3	M27757
Pathway	REACTOME_SIGNALING_BY_NOTCH	EGFR EP300 NOTCH1	1.30e-05	39	17	3	MM14604
Pathway	BIOCARTA_PELP1_PATHWAY	CREBBP EP300	1.37e-05	5	17	2	MM1575
Pathway	REACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES	CREBBP EP300	1.37e-05	5	17	2	M48020
Pathway	REACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION	CREBBP EP300	1.37e-05	5	17	2	M27228
Pathway	REACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES	CREBBP EP300	1.37e-05	5	17	2	M48023
Pathway	REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT	CREBBP EP300 NOTCH1	1.62e-05	42	17	3	M17541
Pathway	BIOCARTA_PELP1_PATHWAY	CREBBP EP300	2.05e-05	6	17	2	M22062
Pathway	PID_PS1_PATHWAY	CREBBP NOTCH1 WIF1	2.14e-05	46	17	3	M70
Pathway	KEGG_NOTCH_SIGNALING_PATHWAY	CREBBP EP300 NOTCH1	2.29e-05	47	17	3	M7946
Pathway	PID_HES_HEY_PATHWAY	CREBBP EP300 NOTCH1	2.44e-05	48	17	3	M288
Pathway	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	CREBBP EP300 NOTCH1	2.44e-05	48	17	3	M611
Pathway	KEGG_WNT_SIGNALING_PATHWAY	CREBBP EP300 WIF1 CXXC4	2.70e-05	151	17	4	M19428
Pathway	BIOCARTA_PPARG_PATHWAY	CREBBP EP300	2.86e-05	7	17	2	MM1573
Pathway	BIOCARTA_PPARG_PATHWAY	CREBBP EP300	3.82e-05	8	17	2	M22058
Pathway	REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES	CREBBP EP300	3.82e-05	8	17	2	M48022
Pathway	REACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES	CREBBP EP300	3.82e-05	8	17	2	M46443
Pathway	REACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER	CREBBP EP300 NOTCH1	4.31e-05	58	17	3	M29616
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY	CREBBP EP300	4.90e-05	9	17	2	M47451
Pathway	WP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA	CREBBP EP300 NOTCH1	6.08e-05	65	17	3	M39682
Pathway	REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING	EP300 NOTCH1	6.12e-05	10	17	2	MM15535
Pathway	REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION	CREBBP EP300	6.12e-05	10	17	2	M27945
Pathway	WP_UROTENSINIIMEDIATED_SIGNALING	EGFR CREBBP EP300	7.27e-05	69	17	3	M48052
Pathway	REACTOME_FORMATION_OF_PARAXIAL_MESODERM	CREBBP EP300 NOTCH1	7.27e-05	69	17	3	M46439
Pathway	BIOCARTA_CARM1_PATHWAY	CREBBP EP300	7.48e-05	11	17	2	MM1521
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR	CREBBP EP300	7.48e-05	11	17	2	M26924
Pathway	KEGG_ADHERENS_JUNCTION	EGFR CREBBP EP300	8.60e-05	73	17	3	M638
Pathway	REACTOME_SIGNALING_BY_NOTCH1	CREBBP EP300 NOTCH1	8.96e-05	74	17	3	M616
Pathway	BIOCARTA_CARM1_PATHWAY	CREBBP EP300	8.97e-05	12	17	2	M7968
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	CREBBP EP300	8.97e-05	12	17	2	M27765
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	LMO1 ZNF620 EGFR KMT2A CREBBP EP300 NOTCH1 ZNF667	9.28e-05	1387	17	8	M734
Pathway	REACTOME_ESR_MEDIATED_SIGNALING	CXXC5 EGFR CREBBP EP300	1.17e-04	220	17	4	M27794
Pathway	REACTOME_SIGNALING_BY_NOTCH4	CREBBP EP300 NOTCH1	1.22e-04	82	17	3	M594
Pathway	WP_DELTANOTCH_SIGNALING_PATHWAY	EGFR EP300 NOTCH1	1.22e-04	82	17	3	MM15922
Pathway	WP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS	EGFR CREBBP EP300	1.40e-04	86	17	3	M39375
Pathway	BIOCARTA_RELA_PATHWAY	CREBBP EP300	1.42e-04	15	17	2	MM1339
Pathway	BIOCARTA_RELA_PATHWAY	CREBBP EP300	1.42e-04	15	17	2	M10183
Pathway	BIOCARTA_PITX2_PATHWAY	CREBBP EP300	1.42e-04	15	17	2	MM1439
Pathway	REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY	CREBBP EP300	1.42e-04	15	17	2	M953
Pathway	WP_HAIR_FOLLICLE_DEVELOPMENT_CYTODIFFERENTIATION_STAGE_3_OF_3	EGFR NOTCH1 WIF1	1.45e-04	87	17	3	M39465
Pathway	REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT	CREBBP EP300 WIF1 CXXC4	1.46e-04	233	17	4	M27099
Pathway	KEGG_PROSTATE_CANCER	EGFR CREBBP EP300	1.55e-04	89	17	3	M13191
Pathway	WNT_SIGNALING	EP300 WIF1 CXXC4	1.55e-04	89	17	3	M5493
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1	LMO1 KMT2A CREBBP EP300	1.56e-04	237	17	4	M27786
Pathway	BIOCARTA_IL7_PATHWAY	CREBBP EP300	1.63e-04	16	17	2	M1296
Pathway	BIOCARTA_IL7_PATHWAY	CREBBP EP300	1.63e-04	16	17	2	MM1420
Pathway	BIOCARTA_PITX2_PATHWAY	CREBBP EP300	1.63e-04	16	17	2	M8516
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES	CREBBP EP300	1.63e-04	16	17	2	M27940
Pathway	WP_ANDROGEN_RECEPTOR_SIGNALING	EGFR CREBBP EP300	1.66e-04	91	17	3	M39700
Pathway	REACTOME_SIGNALING_BY_NOTCH	EGFR CREBBP EP300 NOTCH1	1.80e-04	246	17	4	M10189
Pathway	BIOCARTA_TGFB_PATHWAY	CREBBP EP300	1.84e-04	17	17	2	MM1509
Pathway	REACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA	CREBBP EP300	1.84e-04	17	17	2	M48025
Pathway	REACTOME_NUCLEAR_EVENTS_MEDIATED_BY_NFE2L2	CREBBP EP300 NOTCH1	1.94e-04	96	17	3	M45026
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3	CREBBP EP300 NOTCH1	1.94e-04	96	17	3	M27784
Pathway	REACTOME_SIGNALING_BY_NOTCH1	EP300 NOTCH1	2.07e-04	18	17	2	MM14775
Pathway	REACTOME_RORA_ACTIVATES_GENE_EXPRESSION	CREBBP EP300	2.07e-04	18	17	2	M26942
Pathway	BIOCARTA_TGFB_PATHWAY	CREBBP EP300	2.31e-04	19	17	2	M18933
Pathway	REACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES	CREBBP EP300	2.31e-04	19	17	2	M46442
Pathway	WP_CANCER_PATHWAYS	EGFR CREBBP HHIP EP300 NOTCH1	2.55e-04	507	17	5	M48302
Pathway	WP_BMP_SIGNALING_PATHWAY_IN_EYELID_DEVELOPMENT	EGFR NOTCH1	2.57e-04	20	17	2	MM15907
Pathway	WP_BMP_SIGNALING_IN_EYELID_DEVELOPMENT	EGFR NOTCH1	2.57e-04	20	17	2	M39624
Pathway	WP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX	CREBBP EP300	2.84e-04	21	17	2	M39593
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	CREBBP EP300	2.84e-04	21	17	2	M27485
Pathway	BIOCARTA_NTHI_PATHWAY	CREBBP EP300	3.12e-04	22	17	2	MM1443
Pathway	WP_HEDGEHOG_SIGNALING_PATHWAY	CREBBP HHIP	3.12e-04	22	17	2	MM15924
Pathway	BIOCARTA_VDR_PATHWAY	CREBBP EP300	3.12e-04	22	17	2	MM1370
Pathway	BIOCARTA_HER2_PATHWAY	EGFR EP300	3.41e-04	23	17	2	MM1480
Pathway	BIOCARTA_WNT_PATHWAY	CREBBP WIF1	3.41e-04	23	17	2	MM1527
Pathway	BIOCARTA_HER2_PATHWAY	EGFR EP300	3.41e-04	23	17	2	M18719
Pathway	BIOCARTA_NTHI_PATHWAY	CREBBP EP300	3.41e-04	23	17	2	M2821
Pathway	REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS	CXXC5 EGFR CREBBP EP300	3.65e-04	296	17	4	M27869
Pathway	REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING	CREBBP EP300 NOTCH1	3.66e-04	119	17	3	M607
Pathway	KEGG_DORSO_VENTRAL_AXIS_FORMATION	EGFR NOTCH1	3.72e-04	24	17	2	M11190
Pathway	BIOCARTA_WNT_PATHWAY	CREBBP WIF1	3.72e-04	24	17	2	M16517
Pathway	BIOCARTA_VDR_PATHWAY	CREBBP EP300	3.72e-04	24	17	2	M13404
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY	EGFR CREBBP EP300	3.75e-04	120	17	3	M48233
Pathway	REACTOME_KEAP1_NFE2L2_PATHWAY	CREBBP EP300 NOTCH1	4.23e-04	125	17	3	M45021
Pathway	BIOCARTA_CARM_ER_PATHWAY	CREBBP EP300	4.37e-04	26	17	2	M2499
Pathway	PID_HDAC_CLASSIII_PATHWAY	CREBBP EP300	4.37e-04	26	17	2	M32
Pathway	WP_EBOLA_VIRUS_INFECTION_IN_HOST	EGFR CREBBP EP300	4.63e-04	129	17	3	M39693
Pathway	REACTOME_GASTRULATION	CREBBP EP300 NOTCH1	4.63e-04	129	17	3	M46433
Pathway	REACTOME_ATTENUATION_PHASE	CREBBP EP300	5.08e-04	28	17	2	M27254
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	CREBBP NOTCH1	5.08e-04	28	17	2	M6177
Pathway	KEGG_PATHWAYS_IN_CANCER	EGFR CREBBP HHIP EP300	5.20e-04	325	17	4	M12868
Pathway	REACTOME_SIGNALING_BY_WNT	CREBBP EP300 WIF1 CXXC4	5.51e-04	330	17	4	M7847
Pathway	PID_P53_DOWNSTREAM_PATHWAY	EGFR CREBBP EP300	5.53e-04	137	17	3	M145
Pathway	PID_RETINOIC_ACID_PATHWAY	CREBBP EP300	5.84e-04	30	17	2	M207
Pathway	REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION	CREBBP EP300	5.84e-04	30	17	2	M936
Pathway	WP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR	CREBBP EP300	6.65e-04	32	17	2	M39521
Pathway	REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION	CXXC5 CREBBP EP300	7.06e-04	149	17	3	M27888
Pathway	WP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA	CREBBP EP300	7.51e-04	34	17	2	M39771
Pathway	PID_HIF2PATHWAY	CREBBP EP300	7.51e-04	34	17	2	M44
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1	LMO1 KMT2A EP300	7.62e-04	153	17	3	MM15522
Pubmed	Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300.	KMT2A CREBBP EP300	4.65e-10	4	18	3	17707401
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	CXXC5 KMT2A CXXC4	1.39e-08	10	18	3	29276034
Pubmed	Loss of p300 accelerates MDS-associated leukemogenesis.	CREBBP EP300	2.53e-07	2	18	2	27881875
Pubmed	Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.	CREBBP EP300	2.53e-07	2	18	2	34845315
Pubmed	p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.	CREBBP EP300	2.53e-07	2	18	2	19729597
Pubmed	CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.	CREBBP EP300	2.53e-07	2	18	2	39287984
Pubmed	Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain.	KMT2A CREBBP	2.53e-07	2	18	2	12205094
Pubmed	Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.	CREBBP EP300	2.53e-07	2	18	2	20717166
Pubmed	The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.	CREBBP EP300	2.53e-07	2	18	2	25893291
Pubmed	Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.	CREBBP EP300	2.53e-07	2	18	2	11559821
Pubmed	CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.	CREBBP EP300	2.53e-07	2	18	2	32576962
Pubmed	Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.	CREBBP EP300	2.53e-07	2	18	2	19822209
Pubmed	A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.	CREBBP EP300	2.53e-07	2	18	2	24522976
Pubmed	CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.	CREBBP EP300	2.53e-07	2	18	2	21847097
Pubmed	Wif1 hypermethylation as unfavorable prognosis of non-small cell lung cancers with EGFR mutation.	EGFR WIF1	2.53e-07	2	18	2	23686431
Pubmed	[Cross-talk between Notch1 and epidermal growth factor receptor signalling in regulating cell proliferation of human tongue squamous carcinoma cells].	EGFR NOTCH1	2.53e-07	2	18	2	20193370
Pubmed	p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.	CREBBP EP300	2.53e-07	2	18	2	34813504
Pubmed	Rubinstein-Taybi Syndrome	CREBBP EP300	2.53e-07	2	18	2	20301699
Pubmed	Potential biomarker of metformin action.	CREBBP EP300	2.53e-07	2	18	2	24639469
Pubmed	The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.	CREBBP EP300	2.53e-07	2	18	2	37816914
Pubmed	Binding of p300/CBP co-activators by polyoma large T antigen.	CREBBP EP300	2.53e-07	2	18	2	11438528
Pubmed	Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.	CREBBP EP300	2.53e-07	2	18	2	10918613
Pubmed	Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivo.	EGFR NOTCH1	2.53e-07	2	18	2	23916913
Pubmed	Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.	CREBBP EP300	2.53e-07	2	18	2	35502657
Pubmed	p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival.	CREBBP EP300	2.53e-07	2	18	2	31898871
Pubmed	NOTCH1 and CREBBP co-mutations negatively affect the benefit of adjuvant therapy in completely resected EGFR-mutated NSCLC: translational research of phase III IMPACT study.	CREBBP NOTCH1	2.53e-07	2	18	2	37864465
Pubmed	Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.	CREBBP EP300	2.53e-07	2	18	2	30888860
Pubmed	Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.	CREBBP EP300	2.53e-07	2	18	2	27881443
Pubmed	Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts.	CREBBP EP300	2.53e-07	2	18	2	19272189
Pubmed	Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.	CREBBP EP300	2.53e-07	2	18	2	32690000
Pubmed	CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.	CREBBP EP300	2.53e-07	2	18	2	30953353
Pubmed	Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.	CREBBP EP300	2.53e-07	2	18	2	21803292
Pubmed	HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.	CREBBP EP300	2.53e-07	2	18	2	9811832
Pubmed	Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.	CREBBP EP300	2.53e-07	2	18	2	24089570
Pubmed	Multilocus association of genetic variants in MLL, CREBBP, EP300, and TOP2A with childhood acute lymphoblastic leukemia in Hispanics from Texas.	KMT2A EP300	2.53e-07	2	18	2	21493871
Pubmed	Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.	CREBBP EP300	2.53e-07	2	18	2	15706485
Pubmed	AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.	CREBBP EP300	2.53e-07	2	18	2	39266679
Pubmed	A boy with classical Rubinstein-Taybi syndrome but no detectable mutation in the CREBBP and EP300 genes.	CREBBP EP300	2.53e-07	2	18	2	22303793
Pubmed	Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.	CREBBP EP300	2.53e-07	2	18	2	34732714
Pubmed	Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.	CREBBP EP300	2.53e-07	2	18	2	34019788
Pubmed	Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation.	CREBBP EP300	2.53e-07	2	18	2	15860545
Pubmed	Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.	CREBBP EP300	2.53e-07	2	18	2	29460469
Pubmed	Synchronized Targeting of Notch and ERBB Signaling Suppresses Melanoma Tumor Growth through Inhibition of Notch1 and ERBB3.	EGFR NOTCH1	2.53e-07	2	18	2	26967479
Pubmed	Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.	CREBBP EP300	2.53e-07	2	18	2	24551300
Pubmed	Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.	CREBBP EP300	2.53e-07	2	18	2	33911074
Pubmed	The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.	CREBBP EP300	2.53e-07	2	18	2	9018065
Pubmed	Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure.	CREBBP EP300	2.53e-07	2	18	2	24648406
Pubmed	CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.	CREBBP EP300	2.53e-07	2	18	2	30135524
Pubmed	Distribution of co-activators CBP and p300 during mouse oocyte and embryo development.	CREBBP EP300	2.53e-07	2	18	2	16596650
Pubmed	The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.	CREBBP EP300	2.53e-07	2	18	2	29217654
Pubmed	Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.	CREBBP EP300	2.53e-07	2	18	2	10049825
Pubmed	CBP/p300 acetyltransferase activity in hematologic malignancies.	CREBBP EP300	2.53e-07	2	18	2	27380996
Pubmed	CREBBP and p300 lysine acetyl transferases in the DNA damage response.	CREBBP EP300	2.53e-07	2	18	2	29170789
Pubmed	Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.	CREBBP EP300	2.53e-07	2	18	2	21555743
Pubmed	CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells.	CREBBP EP300	2.53e-07	2	18	2	12646247
Pubmed	Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice.	CREBBP EP300	2.53e-07	2	18	2	11867645
Pubmed	Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue.	CREBBP EP300	2.53e-07	2	18	2	11963968
Pubmed	Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.	CREBBP EP300	2.53e-07	2	18	2	9528808
Pubmed	Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.	CREBBP EP300	2.53e-07	2	18	2	12696060
Pubmed	Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain.	KMT2A CREBBP	2.53e-07	2	18	2	20969867
Pubmed	CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.	CREBBP EP300	2.53e-07	2	18	2	36109165
Pubmed	Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300.	CREBBP EP300	2.53e-07	2	18	2	12242694
Pubmed	Elevated expression of Notch-1 and EGFR induced apoptosis in glioblastoma multiforme patients.	EGFR NOTCH1	2.53e-07	2	18	2	25704190
Pubmed	CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms.	CREBBP EP300	2.53e-07	2	18	2	31182547
Pubmed	T-cell lymphoblastic leukemia in early childhood presents NOTCH1 mutations and MLL rearrangements.	KMT2A NOTCH1	2.53e-07	2	18	2	19631984
Pubmed	Rubinstein-Taybi syndrome in a Saudi boy with distinct features and variants in both the CREBBP and EP300 genes: a case report.	CREBBP EP300	2.53e-07	2	18	2	30635043
Pubmed	Phenotype and genotype in 52 patients with Rubinstein-Taybi syndrome caused by EP300 mutations.	CREBBP EP300	2.53e-07	2	18	2	27648933
Pubmed	Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis.	CREBBP EP300	2.53e-07	2	18	2	10610021
Pubmed	Emerging roles of p300/CBP in autophagy and autophagy-related human disorders.	CREBBP EP300	2.53e-07	2	18	2	37314181
Pubmed	Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal.	CREBBP EP300	2.53e-07	2	18	2	12397173
Pubmed	CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding.	CREBBP EP300	2.53e-07	2	18	2	15641773
Pubmed	Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein.	CREBBP EP300	2.53e-07	2	18	2	9733868
Pubmed	EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.	EGFR NOTCH1	2.53e-07	2	18	2	18604200
Pubmed	Rubinstein-Taybi syndrome in Chinese population with four novel mutations.	CREBBP EP300	2.53e-07	2	18	2	33063428
Pubmed	EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling.	CREBBP EP300	2.53e-07	2	18	2	34506759
Pubmed	Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms.	CREBBP EP300	2.53e-07	2	18	2	22177454
Pubmed	iRhom2 mutation leads to aberrant hair follicle differentiation in mice.	EGFR NOTCH1 WIF1	4.68e-07	30	18	3	25546423
Pubmed	The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.	CREBBP EP300	7.59e-07	3	18	2	18070920
Pubmed	Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.	CREBBP EP300	7.59e-07	3	18	2	27903646
Pubmed	Inhibition of p300/CBP by early B-cell factor.	CREBBP EP300	7.59e-07	3	18	2	12748286
Pubmed	Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression.	CREBBP EP300	7.59e-07	3	18	2	24340053
Pubmed	Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response.	CREBBP EP300	7.59e-07	3	18	2	19273602
Pubmed	Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.	CREBBP EP300	7.59e-07	3	18	2	15649887
Pubmed	MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways.	EGFR NOTCH1	7.59e-07	3	18	2	21622856
Pubmed	DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes.	CREBBP EP300	7.59e-07	3	18	2	26951377
Pubmed	CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes.	CREBBP EP300	7.59e-07	3	18	2	21789216
Pubmed	Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.	CREBBP EP300	7.59e-07	3	18	2	12050117
Pubmed	Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.	CREBBP EP300	7.59e-07	3	18	2	16237459
Pubmed	The IFNgamma-induced STAT1-CBP/P300 association, required for a normal response to the cytokine, is disrupted in Brucella-infected macrophages.	CREBBP EP300	7.59e-07	3	18	2	19041714
Pubmed	Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.	CREBBP EP300	7.59e-07	3	18	2	12776737
Pubmed	Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.	CREBBP EP300	7.59e-07	3	18	2	14759370
Pubmed	Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.	CREBBP EP300	7.59e-07	3	18	2	22474372
Pubmed	Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1.	CREBBP EP300	7.59e-07	3	18	2	9488451
Pubmed	Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression.	CREBBP EP300	7.59e-07	3	18	2	15782138
Pubmed	p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint.	CREBBP EP300	7.59e-07	3	18	2	17272271
Pubmed	Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions.	CREBBP EP300	7.59e-07	3	18	2	12473110
Pubmed	Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes.	CREBBP EP300	7.59e-07	3	18	2	15598887
Pubmed	The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.	CREBBP EP300	7.59e-07	3	18	2	25689462
Pubmed	Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.	CREBBP EP300	7.59e-07	3	18	2	16428436
Pubmed	Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.	CREBBP EP300	7.59e-07	3	18	2	11823864
Interaction	MAML2 interactions	CREBBP EP300 NOTCH1	3.37e-07	17	17	3	int:MAML2
Interaction	ZBTB17 interactions	EGFR CREBBP EP300 ZNF667	4.51e-07	77	17	4	int:ZBTB17
Interaction	TAL1 interactions	LMO1 CREBBP EP300 RPL34	9.66e-07	93	17	4	int:TAL1
Interaction	CNTN2 interactions	EGFR CREBBP EP300	9.98e-07	24	17	3	int:CNTN2
Interaction	CDC27 interactions	EGFR KMT2A CREBBP EP300 NOTCH1	1.52e-06	249	17	5	int:CDC27
Interaction	MYB interactions	KMT2A CREBBP EP300 RPL34	4.04e-06	133	17	4	int:MYB
Interaction	BBC3 interactions	EGFR CREBBP EP300	4.13e-06	38	17	3	int:BBC3
Interaction	ANAPC5 interactions	EGFR CREBBP EP300 NOTCH1	4.67e-06	138	17	4	int:ANAPC5
Interaction	CCN2 interactions	EGFR CREBBP EP300	4.83e-06	40	17	3	int:CCN2
Interaction	GABPB1 interactions	LMO1 EGFR EP300	6.03e-06	43	17	3	int:GABPB1
Interaction	POLR1E interactions	EGFR KMT2A CREBBP RPL34 WIF1	8.00e-06	350	17	5	int:POLR1E
Interaction	SMARCC2 interactions	EGFR KMT2A CREBBP EP300 NOTCH1	8.34e-06	353	17	5	int:SMARCC2
Interaction	ZNF24 interactions	LMO1 ZNF620 EP300 ZNF667	1.17e-05	174	17	4	int:ZNF24
Interaction	ELF3 interactions	EGFR CREBBP EP300	1.20e-05	54	17	3	int:ELF3
Interaction	ZBTB43 interactions	LMO1 EGFR ZNF667	1.34e-05	56	17	3	int:ZBTB43
Interaction	LDB2 interactions	LMO1 CREBBP EP300	1.34e-05	56	17	3	int:LDB2
Interaction	GATA3 interactions	LMO1 CREBBP EP300 RPL34	1.55e-05	187	17	4	int:GATA3
Interaction	HOXA10 interactions	KMT2A CREBBP EP300	1.83e-05	62	17	3	int:HOXA10
Interaction	DEAF1 interactions	EGFR CREBBP EP300	2.01e-05	64	17	3	int:DEAF1
Interaction	HOXB3 interactions	CREBBP EP300	2.40e-05	9	17	2	int:HOXB3
Interaction	ARGFX interactions	CREBBP EP300	2.40e-05	9	17	2	int:ARGFX
Interaction	DUX4 interactions	EGFR CREBBP EP300 RPL34	2.64e-05	214	17	4	int:DUX4
Interaction	NABP2 interactions	EGFR EP300 RPL34	2.87e-05	72	17	3	int:NABP2
Interaction	MAML1 interactions	CREBBP EP300 NOTCH1	2.99e-05	73	17	3	int:MAML1
Interaction	TGS1 interactions	EGFR CREBBP EP300	3.24e-05	75	17	3	int:TGS1
Interaction	ING4 interactions	EGFR KMT2A EP300	3.65e-05	78	17	3	int:ING4
Interaction	CHRDL1 interactions	CHRDL1 CREBBP	3.67e-05	11	17	2	int:CHRDL1
Interaction	UBTF interactions	EGFR CREBBP EP300 WIF1	3.74e-05	234	17	4	int:UBTF
Interaction	CDC20 interactions	EGFR KMT2A CREBBP EP300	3.74e-05	234	17	4	int:CDC20
Interaction	MIER1 interactions	EGFR CREBBP EP300	3.93e-05	80	17	3	int:MIER1
Interaction	PRKCD interactions	EGFR CREBBP EP300 NOTCH1	4.00e-05	238	17	4	int:PRKCD
Interaction	STAT2 interactions	EGFR CREBBP EP300	4.08e-05	81	17	3	int:STAT2
Interaction	PPARGC1A interactions	EGFR CREBBP EP300	4.24e-05	82	17	3	int:PPARGC1A
Interaction	SELENOP interactions	EGFR EP300	4.40e-05	12	17	2	int:SELENOP
Interaction	RBPJ interactions	KMT2A CREBBP EP300 NOTCH1	5.15e-05	254	17	4	int:RBPJ
Interaction	HMGB2 interactions	EGFR CREBBP EP300 RPL34	5.48e-05	258	17	4	int:HMGB2
Interaction	ROBO4 interactions	EGFR EP300	6.06e-05	14	17	2	int:ROBO4
Interaction	RERE interactions	ZNF620 KMT2A EP300	6.17e-05	93	17	3	int:RERE
Interaction	KLF2 interactions	CREBBP EP300	6.99e-05	15	17	2	int:KLF2
Interaction	RWDD1 interactions	EGFR EP300	6.99e-05	15	17	2	int:RWDD1
Interaction	BANP interactions	LMO1 EGFR DNAJA4 EP300	7.22e-05	277	17	4	int:BANP
Interaction	CLOCK interactions	KMT2A CREBBP EP300	8.13e-05	102	17	3	int:CLOCK
Interaction	CCT6A interactions	EGFR KMT2A DNAJA4 EP300 NOTCH1	8.30e-05	570	17	5	int:CCT6A
Interaction	RBBP4 interactions	EGFR KMT2A CREBBP EP300 NOTCH1	8.51e-05	573	17	5	int:RBBP4
Interaction	BMAL1 interactions	KMT2A CREBBP EP300	1.05e-04	111	17	3	int:BMAL1
Interaction	NEUROG1 interactions	CREBBP EP300	1.14e-04	19	17	2	int:NEUROG1
Interaction	DBP interactions	KMT2A EP300	1.14e-04	19	17	2	int:DBP
Interaction	SPIB interactions	CREBBP EP300	1.26e-04	20	17	2	int:SPIB
Interaction	DNAH8 interactions	EGFR KMT2A	1.26e-04	20	17	2	int:DNAH8
Interaction	NMD3 interactions	EGFR EP300 WIF1	1.32e-04	120	17	3	int:NMD3
Interaction	RUNX1 interactions	KMT2A CREBBP EP300 NOTCH1	1.32e-04	324	17	4	int:RUNX1
Interaction	ETS1 interactions	EGFR CREBBP EP300	1.35e-04	121	17	3	int:ETS1
Interaction	HOXB4 interactions	CREBBP EP300	1.39e-04	21	17	2	int:HOXB4
Interaction	PLAGL1 interactions	CREBBP EP300	1.39e-04	21	17	2	int:PLAGL1
Interaction	KLF13 interactions	CREBBP EP300	1.39e-04	21	17	2	int:KLF13
Interaction	CITED4 interactions	CREBBP EP300	1.39e-04	21	17	2	int:CITED4
Interaction	FOXO3 interactions	EGFR CREBBP EP300	1.45e-04	124	17	3	int:FOXO3
Interaction	VDR interactions	CXXC5 CREBBP EP300	1.56e-04	127	17	3	int:VDR
Interaction	EHD4 interactions	EGFR EP300 WIF1	1.59e-04	128	17	3	int:EHD4
Interaction	FHL1 interactions	EGFR CREBBP EP300	1.63e-04	129	17	3	int:FHL1
Interaction	GABPA interactions	EGFR CREBBP EP300	1.67e-04	130	17	3	int:GABPA
Interaction	CITED2 interactions	CREBBP EP300	1.68e-04	23	17	2	int:CITED2
Interaction	HOXD10 interactions	CREBBP EP300	1.68e-04	23	17	2	int:HOXD10
Interaction	NR6A1 interactions	CREBBP EP300	1.83e-04	24	17	2	int:NR6A1
Interaction	TBX21 interactions	CREBBP EP300	1.83e-04	24	17	2	int:TBX21
Interaction	ALX1 interactions	CREBBP EP300	1.99e-04	25	17	2	int:ALX1
Interaction	UBE2S interactions	EGFR CREBBP EP300	1.99e-04	138	17	3	int:UBE2S
Interaction	CSTF3 interactions	EGFR EP300 WIF1	2.03e-04	139	17	3	int:CSTF3
Interaction	GTF2B interactions	EGFR CREBBP EP300	2.12e-04	141	17	3	int:GTF2B
Interaction	HOXB7 interactions	CREBBP EP300	2.15e-04	26	17	2	int:HOXB7
Interaction	CTBP2 interactions	EGFR CREBBP EP300 WIF1	2.20e-04	370	17	4	int:CTBP2
Interaction	RPS6KA5 interactions	KMT2A CREBBP EP300	2.26e-04	144	17	3	int:RPS6KA5
Interaction	PNPT1 interactions	EGFR EP300 WIF1	2.30e-04	145	17	3	int:PNPT1
Interaction	NCOA6 interactions	KMT2A CREBBP EP300	2.30e-04	145	17	3	int:NCOA6
Interaction	TLE3 interactions	KMT2A CREBBP EP300 NOTCH1	2.34e-04	376	17	4	int:TLE3
Interaction	CPSF3 interactions	LMO1 EGFR EP300	2.35e-04	146	17	3	int:CPSF3
Interaction	TCF12 interactions	CREBBP EP300 NOTCH1	2.45e-04	148	17	3	int:TCF12
Interaction	NFS1 interactions	EGFR EP300 WIF1	2.50e-04	149	17	3	int:NFS1
Interaction	SMARCC1 interactions	KMT2A CREBBP EP300 NOTCH1	2.54e-04	384	17	4	int:SMARCC1
Interaction	RTF1 interactions	EGFR KMT2A EP300	2.55e-04	150	17	3	int:RTF1
Interaction	CDC25A interactions	EGFR CREBBP EP300	2.60e-04	151	17	3	int:CDC25A
Interaction	REL interactions	LMO1 CREBBP EP300 NOTCH1	2.64e-04	388	17	4	int:REL
Interaction	MN1 interactions	LMO1 EP300	2.68e-04	29	17	2	int:MN1
Interaction	MYOCD interactions	EGFR EP300	2.68e-04	29	17	2	int:MYOCD
Interaction	MAP3K5 interactions	KMT2A CREBBP EP300	2.70e-04	153	17	3	int:MAP3K5
Interaction	PPP1CC interactions	EGFR CREBBP EP300 RPL34 ZNF667	2.78e-04	738	17	5	int:PPP1CC
Interaction	OXSR1 interactions	EGFR EP300 WIF1	2.80e-04	155	17	3	int:OXSR1
Interaction	FHL2 interactions	ZNF620 EGFR CREBBP EP300	2.85e-04	396	17	4	int:FHL2
Interaction	CDC25C interactions	LMO1 EGFR EP300	2.86e-04	156	17	3	int:CDC25C
Interaction	HOXD4 interactions	CREBBP EP300	2.87e-04	30	17	2	int:HOXD4
Interaction	NAA15 interactions	EGFR EP300 WIF1	2.97e-04	158	17	3	int:NAA15
Interaction	AVP interactions	EGFR KMT2A	3.07e-04	31	17	2	int:AVP
Interaction	CRTC1 interactions	CREBBP EP300	3.07e-04	31	17	2	int:CRTC1
Interaction	CTBP1 interactions	EGFR KMT2A CREBBP EP300	3.14e-04	406	17	4	int:CTBP1
Interaction	ANAPC7 interactions	CREBBP EP300 NOTCH1	3.19e-04	162	17	3	int:ANAPC7
Interaction	MYBL2 interactions	EGFR CREBBP EP300	3.19e-04	162	17	3	int:MYBL2
Interaction	SUPT5H interactions	EGFR KMT2A EP300 WIF1	3.20e-04	408	17	4	int:SUPT5H
Interaction	NEUROD1 interactions	CREBBP EP300	3.27e-04	32	17	2	int:NEUROD1
Interaction	CDH1 interactions	EGFR CREBBP EP300 NOTCH1 RPL34	3.35e-04	768	17	5	int:CDH1
Interaction	TRERF1 interactions	CREBBP EP300	3.48e-04	33	17	2	int:TRERF1
GeneFamily	Zinc fingers CXXC-type	CXXC5 KMT2A CXXC4	6.36e-08	12	13	3	136
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	CREBBP EP300	6.45e-05	17	13	2	486
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	CREBBP EP300	7.25e-05	18	13	2	91
Coexpression	GRESHOCK_CANCER_COPY_NUMBER_UP	LMO1 EGFR KMT2A CREBBP EP300 NOTCH1	3.69e-08	323	17	6	M9150
Coexpression	SCHLESINGER_METHYLATED_IN_COLON_CANCER	HHIP WIF1	1.78e-05	10	17	2	M821
Coexpression	MARTINEZ_RB1_AND_TP53_TARGETS_DN	CXXC5 EGFR HHIP NOTCH1 RPL34	3.30e-05	610	17	5	M3854
Coexpression	MARTINEZ_TP53_TARGETS_DN	CXXC5 EGFR HHIP NOTCH1 RPL34	3.43e-05	615	17	5	M8673
Coexpression	MARTINEZ_RB1_AND_TP53_TARGETS_DN	CXXC5 EGFR HHIP NOTCH1 RPL34	4.46e-05	650	17	5	MM1042
Coexpression	MARTINEZ_TP53_TARGETS_DN	CXXC5 EGFR HHIP NOTCH1 RPL34	4.76e-05	659	17	5	MM1040
Coexpression	LEE_NEURAL_CREST_STEM_CELL_DN	CHRDL1 NOTCH1 WIF1	6.38e-05	122	17	3	M10276
Coexpression	TRAVAGLINI_LUNG_FIBROMYOCYTE_CELL	HHIP WIF1	1.18e-04	25	17	2	M41674
Coexpression	GSE3982_EOSINOPHIL_VS_BCELL_UP	CHRDL1 NOTCH1 WIF1	2.71e-04	199	17	3	M5406
Coexpression	GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP	CXXC5 PPP1R3G ZNF667	2.75e-04	200	17	3	M9748
Coexpression	GSE369_PRE_VS_POST_IL6_INJECTION_IFNG_KO_LIVER_DN	KMT2A DNAJA4 NOTCH1	2.75e-04	200	17	3	M5975
Coexpression	GSE9650_NAIVE_VS_EFF_CD8_TCELL_UP	CXXC5 KMT2A NOTCH1	2.75e-04	200	17	3	M5819
Coexpression	KAECH_DAY8_EFF_VS_DAY15_EFF_CD8_TCELL_DN	CXXC5 KMT2A CREBBP	2.75e-04	200	17	3	M3025
Coexpression	KAECH_NAIVE_VS_DAY8_EFF_CD8_TCELL_UP	CXXC5 KMT2A NOTCH1	2.75e-04	200	17	3	M3012
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	LMO1 EGFR HHIP NOTCH1 WIF1	4.69e-04	1074	17	5	M1941
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHRDL1 DNAJA4 HHIP WIF1	5.92e-07	182	17	4	37547b36264090b49a193a8ef3a8d88e647f0b79
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	EGFR HHIP NLGN1 WIF1	6.18e-07	184	17	4	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	Fibroblasts-CD34+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	CHRDL1 RPL34 NLGN1 WIF1	7.79e-07	195	17	4	c6b5249ac8714b1b701cde31d00ab53f28355c36
ToppCell	Entopeduncular-Macroglia-ASTROCYTE\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	EGFR WIF1 PPP1R3G	1.52e-05	129	17	3	c37bdd6c0b2944fbfa064922954ea0e263160e2a
ToppCell	Entopeduncular-Macroglia-ASTROCYTE-Gja1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	EGFR WIF1 PPP1R3G	1.52e-05	129	17	3	8648ae59f7aca0f5b4983bdb4a65b03b2ca761e1
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor\|bone_marrow / Manually curated celltypes from each tissue	CHRDL1 HHIP ZNF667	2.34e-05	149	17	3	078e1e5765e476ba85c23fb8f6892b6698cbcbdb
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Migrating_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	HHIP WIF1 PPP1R3G	2.63e-05	155	17	3	1882fa5fd25f77d6e3ac47b613f6fb3c67d8e50c
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CHRDL1 HHIP CXXC4	3.23e-05	166	17	3	f416d8a322f086c769659a9fab6b460a2d546ab1
ToppCell	wk_08-11-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CXXC5 CHRDL1 HHIP	3.59e-05	172	17	3	415d57aa6278b8c12e7a2cf9c3fa5283389fb9b0
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EGFR HHIP NLGN1	4.04e-05	179	17	3	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EGFR CHRDL1 WIF1	4.11e-05	180	17	3	392bc71a69653ba12de31bed4e9357f181094641
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EGFR HHIP NLGN1	4.18e-05	181	17	3	0513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EGFR CHRDL1 WIF1	4.18e-05	181	17	3	8fd64404e57c22c204d835fc5626f73554257b19
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 ZNF620 NOTCH1	4.18e-05	181	17	3	f2ebeb4941510c4b6e50f2379c574d1778d6ced1
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EGFR HHIP NLGN1	4.25e-05	182	17	3	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	HHIP NLGN1 WIF1	4.32e-05	183	17	3	de08f9ea02b7244d5a8788064631d10f06565337
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHRDL1 HHIP WIF1	4.32e-05	183	17	3	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EGFR HHIP WIF1	4.32e-05	183	17	3	6847c1252d6bb105524f812658112517fd351eab
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EGFR HHIP NLGN1	4.39e-05	184	17	3	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXXC5 KMT2A EP300	4.39e-05	184	17	3	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	4.39e-05	184	17	3	7712f2e1fae5cdde2d4e355b860dc8536b28e4f6
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-filiform\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXXC5 LMO1 HHIP	4.46e-05	185	17	3	e0c9e92e35fb24351f5347a0768e6aab5add8775
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EGFR HHIP NLGN1	4.53e-05	186	17	3	e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	4.53e-05	186	17	3	76535681667c8afb884fa72b6edfee9e1e46335b
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	HHIP NLGN1 WIF1	4.53e-05	186	17	3	e044b3428b7eacfdc72d0f57cdabaa1de04c74cd
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CHRDL1 HHIP RPL34	4.53e-05	186	17	3	7def03dd856b765bd3f493288641981c4f7fd26e
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EGFR HHIP NLGN1	4.53e-05	186	17	3	e83718fabb057100835d3357df407f283d23fe16
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	4.60e-05	187	17	3	dfc2b95d70daf533bc0cc4ce78af9f65dd75a25b
ToppCell	LPS-antiTNF-Epithelial_alveolar\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EGFR HHIP NLGN1	4.60e-05	187	17	3	201ff693e4756ee3e44762885b3a303a77eb535b
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EGFR HHIP NLGN1	4.68e-05	188	17	3	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	LPS-IL1RA-Epithelial_alveolar\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EGFR HHIP NLGN1	4.68e-05	188	17	3	6164d467b612767ceba15de34176bcc8e8c36ab8
ToppCell	droplet-Tongue-nan-24m-Epithelial-filiform\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXXC5 LMO1 HHIP	4.83e-05	190	17	3	86ab845a7fae2111c0b01e1aec235e19c4c0ef5c
ToppCell	Control-Epithelial-ATII\|Control / Disease state, Lineage and Cell class	EGFR HHIP WIF1	4.83e-05	190	17	3	d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCell	droplet-Tongue-nan-3m-Epithelial-filiform\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXXC5 LMO1 HHIP	4.83e-05	190	17	3	251e3a33041023bfc4b547c7eb68cfb8f421636f
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	4.83e-05	190	17	3	5a82709eeb68df4563bb42b97636d110126d2f97
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHIP WIF1 PPP1R3G	4.90e-05	191	17	3	9d3fa8d8138700640cc7927521c7635299df697d
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR CHRDL1 PPP1R3G	4.90e-05	191	17	3	fd345837bfc40d85256b9a7e4fd3343bcbfe0ae5
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHRDL1 HHIP NLGN1	4.90e-05	191	17	3	24dc77ee8de01b42559f92721655f4281b114e17
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHIP WIF1 PPP1R3G	4.90e-05	191	17	3	d04ed1e04b8cb904237d8e8388fe7740c724237b
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HHIP RPL34 WIF1	4.90e-05	191	17	3	2b0d55a8e1b4ce862dd038f8e0429e8428fb8aba
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	4.90e-05	191	17	3	a53616c84178eb6c29b48662358765b082df3f97
ToppCell	Control-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	EGFR HHIP WIF1	4.98e-05	192	17	3	1bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HHIP WIF1 PPP1R3G	4.98e-05	192	17	3	93903576dddd8227328e4ced75aa7625eedb9baf
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HHIP WIF1 PPP1R3G	5.06e-05	193	17	3	2b80991e7ba7640f7ab2139d30e4c54d8e533862
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHRDL1 HHIP WIF1	5.06e-05	193	17	3	b1893193766ae41bf2ab6ed4083285c9c814e608
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HHIP WIF1 PPP1R3G	5.06e-05	193	17	3	90cfc34c2d0d7c70f071703d35db1d6037961481
ToppCell	Control-NK_CD56bright\|Control / Disease condition and Cell class	CXXC5 NOTCH1 ZNF667	5.06e-05	193	17	3	8b1e7a226a6057e1097c1525984127b54e823876
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HHIP WIF1 PPP1R3G	5.06e-05	193	17	3	cfab88935abe0a15632c5eec8ff00a857ec9b3ed
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	5.06e-05	193	17	3	cdc44bf6f5436eb8a2d4720fe011dcb85ccecf87
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHRDL1 HHIP WIF1	5.13e-05	194	17	3	15060cc25baf49dd04d9c20499e28718610ef754
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HHIP WIF1 PPP1R3G	5.13e-05	194	17	3	7bf6edefd13047e04665dbe34051ef3f481f85a4
ToppCell	IPF-Stromal-Fibroblast\|Stromal / Disease state, Lineage and Cell class	EGFR CHRDL1 NLGN1	5.13e-05	194	17	3	da3e1d39575969a069ef43e552afe94b2f441d0b
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHRDL1 HHIP WIF1	5.13e-05	194	17	3	12a2c60303607b8b5812405ad216d0612c56c64b
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EGFR HHIP WIF1	5.13e-05	194	17	3	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HHIP WIF1 PPP1R3G	5.13e-05	194	17	3	19e5beae2c1f8bf42cbe618e89810ce7b01a396c
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHRDL1 HHIP WIF1	5.13e-05	194	17	3	bea369e9a7018d862e4d7f1c9ec2de50f3fd38ec
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HHIP WIF1 PPP1R3G	5.21e-05	195	17	3	b0d408f8bc1701a87596ed55efcd90749fee33e6
ToppCell	Control-Multiplet\|Control / Disease state, Lineage and Cell class	EGFR HHIP WIF1	5.21e-05	195	17	3	618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHIP WIF1 CXXC4	5.21e-05	195	17	3	d32716a12014522492becbde1088dc1106308490
ToppCell	Control-Multiplet-Multiplet\|Control / Disease state, Lineage and Cell class	EGFR HHIP WIF1	5.21e-05	195	17	3	06ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHIP WIF1 CXXC4	5.21e-05	195	17	3	b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCell	AT2_cells-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	HHIP RPL34 WIF1	5.21e-05	195	17	3	33f60762f00cd6f4757d8a8d5227141558ac823e
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HHIP WIF1 PPP1R3G	5.21e-05	195	17	3	a486a7acea0e91048cc48afa0dbd3926d30bc217
ToppCell	AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	EGFR HHIP WIF1	5.21e-05	195	17	3	b0cea3f4e59635913d243612f2e8cf4c7b34e726
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HHIP WIF1 PPP1R3G	5.21e-05	195	17	3	2414b158dc7bdec43a9671544bfb7ffc5f5168fd
ToppCell	Control-Epithelial\|Control / Disease state, Lineage and Cell class	EGFR HHIP WIF1	5.21e-05	195	17	3	1798c3b89b1b5ff4f5777d2b9f52dc81cdad28fa
ToppCell	Control-Stromal-Fibroblast\|World / Disease state, Lineage and Cell class	EGFR CHRDL1 NLGN1	5.29e-05	196	17	3	1ec7a4daa51b3156db97e1fd6cb925ad311bb4b5
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHRDL1 HHIP WIF1	5.29e-05	196	17	3	988a3e0688e0a7ba69774497d3b130631bb26c50
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HHIP RPL34 WIF1	5.29e-05	196	17	3	fa42a8f8a11645fc733ce9c59c2a0599ecf2176d
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	5.37e-05	197	17	3	1378bf90a4b80b8166ef352c282ce51b114ba693
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	5.45e-05	198	17	3	c8272ac4d90f2367f538f66db40de911ad73ea7f
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HHIP NLGN1 WIF1	5.45e-05	198	17	3	63f7d25201613bd3404c28fb936954190bca91d3
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HHIP NLGN1 WIF1	5.45e-05	198	17	3	a73534b6ca202c277a70a52281d5b97a3e6cb8ef
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	5.45e-05	198	17	3	e442692a8a5aad5b84eabbf051d32eae01b1069a
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HHIP NLGN1 WIF1	5.45e-05	198	17	3	d1e1bdd36c84e1bac21ba137f018defe98456a8c
ToppCell	BAL-Severe-Epithelial-Epithelial-AT1/AT2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EGFR HHIP WIF1	5.45e-05	198	17	3	aed0476248e9637897eefb1623ec4035f2dacd82
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	5.45e-05	198	17	3	36c97eb71b89bac01cabd6a8b728e5a20e52d2a3
ToppCell	BAL-Severe-Epithelial-Epithelial-AT1/AT2-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EGFR HHIP WIF1	5.45e-05	198	17	3	691a2f1779225e5519155460eeb6a2aac5f67a92
ToppCell	BAL-Severe-Epithelial-Epithelial-AT1/AT2\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	EGFR HHIP WIF1	5.45e-05	198	17	3	e115eea04012e9e492e923ed080e1723c38d14fd
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	5.45e-05	198	17	3	c506334d81af672ef9ddc8c4fd2a790bdb58e63e
ToppCell	BAL-Severe-Epithelial-Epithelial-AT1/AT2-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EGFR HHIP WIF1	5.45e-05	198	17	3	33d1e0b6f57663544bee0ffdde83a65da764d44c
ToppCell	Severe_COVID-19-Epithelial-AT1/AT2\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	EGFR HHIP WIF1	5.45e-05	198	17	3	43e33d28d9de5033bd00d39be953542a225236ed
ToppCell	COPD-Stromal-Fibroblast\|World / Disease state, Lineage and Cell class	EGFR CHRDL1 NLGN1	5.45e-05	198	17	3	2f13c0b3372af53d1bd85f9546f315c878580a71
ToppCell	distal-mesenchymal-Myofibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRDL1 WIF1 CXXC4	5.45e-05	198	17	3	beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	EGFR HHIP WIF1	5.54e-05	199	17	3	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	EGFR CHRDL1 NLGN1	5.54e-05	199	17	3	a13f4b8a039304e685464cc8879659824cad5a3e
ToppCell	Parenchymal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	HHIP RPL34 WIF1	5.54e-05	199	17	3	cce684df78421b814083aed16c4cbbac5f287bbc
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	5.54e-05	199	17	3	8d13a9ea87f685b5a34b84c4571db6be753cf2d9
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	5.54e-05	199	17	3	f1d5808ccb1d5d4e2d34f864e705e2484000e88f
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	CHRDL1 HHIP WIF1	5.62e-05	200	17	3	593bf6a7c557437db9a9249a5058a46014179ef6
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-OPC_related-Oligodendrocyte/OPC\|2m / Sample Type, Dataset, Time_group, and Cell type.	LMO1 EGFR NOTCH1	5.62e-05	200	17	3	3c9a2f02294a9fb892b89e856291bd6423ffa0a9
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXXC5 LMO1 NOTCH1	5.62e-05	200	17	3	de55100e98d3e9b8a74e37aebcd3afa2b0996527
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Neuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	CXXC5 CHRDL1 RPL34	5.62e-05	200	17	3	3d134ae3c48ff4d1849db4fbe44ff73fb6c8c779
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-OPC_related\|2m / Sample Type, Dataset, Time_group, and Cell type.	LMO1 EGFR NOTCH1	5.62e-05	200	17	3	8e49e7e9b02d8411e4ffae1f5113a2c18f5bf179
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related-Oligodendrocyte/OPC\|10w / Sample Type, Dataset, Time_group, and Cell type.	CXXC5 LMO1 NOTCH1	5.62e-05	200	17	3	345f1eac498cc87fd7bf08e7312608b2d6fe1dd7
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related\|10w / Sample Type, Dataset, Time_group, and Cell type.	CXXC5 LMO1 NOTCH1	5.62e-05	200	17	3	8f5d98f962ddd8c4658c89ff8a2894de1228562a
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CHRDL1 HHIP WIF1	5.62e-05	200	17	3	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	CHRDL1 HHIP WIF1	5.62e-05	200	17	3	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CHRDL1 HHIP WIF1	5.62e-05	200	17	3	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	Posterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Htra1)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CHRDL1 PPP1R3G	4.82e-04	86	17	2	c1181a7e9f4cbde5a3bee7b54d6448dfce58b238
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; MCF7; HT_HG-U133A	LMO1 KMT2A DNAJA4 CREBBP CXXC4	2.56e-07	196	17	5	6060_UP
Drug	3,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide	CREBBP EP300	5.24e-06	5	17	2	ctd:C575894
Drug	Meticrane [1084-65-7]; Up 200; 14.6uM; PC3; HT_HG-U133A	EGFR KMT2A CREBBP NOTCH1	1.21e-05	198	17	4	7282_UP
Drug	Leucomisine [17946-87-1]; Up 200; 16.2uM; HL60; HT_HG-U133A	KMT2A DNAJA4 WIF1 CXXC4	1.23e-05	199	17	4	6125_UP
Drug	Chromium	CHRDL1 CREBBP HHIP EP300	2.49e-05	238	17	4	ctd:D002857
Drug	Phenylephrine	EGFR CREBBP EP300 WIF1 CXXC4	2.61e-05	505	17	5	ctd:D010656
Drug	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	EGFR CREBBP EP300 NOTCH1 PPP1R3G	4.21e-05	558	17	5	ctd:C072553
Drug	Ursodeoxycholic Acid	EGFR CREBBP EP300 WIF1	4.44e-05	276	17	4	ctd:D014580
Drug	epristeride	EGFR CHRDL1	4.75e-05	14	17	2	CID000068741
Drug	Y 290	KMT2A CHRDL1	7.97e-05	18	17	2	CID000114729
Drug	4,4'-DBP	CREBBP EP300	8.91e-05	19	17	2	CID000007034
Drug	SB 203580	EGFR CREBBP EP300 NOTCH1	1.66e-04	388	17	4	ctd:C093642
Drug	DAPH1	EGFR CXXC4	1.82e-04	27	17	2	CID000133027
Drug	AC1NRB38	HHIP WIF1	1.96e-04	28	17	2	CID005288237
Drug	x MC	EGFR CHRDL1	2.41e-04	31	17	2	CID000017563
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	EGFR CREBBP EP300	2.71e-04	173	17	3	4458_DN
Drug	Curcumin	EGFR CREBBP EP300 NOTCH1 WIF1	3.05e-04	850	17	5	ctd:D003474
Drug	norflurazon	LMO1 CHRDL1	3.08e-04	35	17	2	CID000033775
Drug	baicalin	EGFR NOTCH1	3.26e-04	36	17	2	ctd:C038044
Drug	Niclosamide	CREBBP EP300 NOTCH1	3.62e-04	191	17	3	ctd:D009534
Drug	AG-013608 [351320-38-2]; Down 200; 10uM; PC3; HT_HG-U133A	EGFR KMT2A ZNF667	3.74e-04	193	17	3	6400_DN
Drug	Pramoxine hydrochloride [637-58-1]; Up 200; 12.2uM; PC3; HT_HG-U133A	LMO1 CREBBP WIF1	3.74e-04	193	17	3	3811_UP
Drug	ICI 182,780; Down 200; 1uM; PC3; HT_HG-U133A	EGFR DNAJA4 NOTCH1	3.79e-04	194	17	3	4429_DN
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Up 200; 10.6uM; MCF7; HT_HG-U133A	LMO1 EGFR KMT2A	3.79e-04	194	17	3	5695_UP
Drug	(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; PC3; HT_HG-U133A	KMT2A NOTCH1 ZNF667	3.79e-04	194	17	3	4524_DN
Drug	Nystatine [1400-61-9]; Up 200; 4.4uM; PC3; HT_HG-U133A	KMT2A DNAJA4 CREBBP	3.79e-04	194	17	3	4223_UP
Drug	Flecainide acetate [54143-56-5]; Up 200; 8.4uM; PC3; HT_HG-U133A	EGFR KMT2A DNAJA4	3.85e-04	195	17	3	4318_UP
Drug	5279552; Down 200; 22uM; MCF7; HT_HG-U133A_EA	KMT2A CREBBP EP300	3.85e-04	195	17	3	843_DN
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; PC3; HT_HG-U133A	EGFR CHRDL1 NLGN1	3.85e-04	195	17	3	3755_DN
Drug	Guaifenesin [93-14-1]; Up 200; 20.2uM; PC3; HT_HG-U133A	KMT2A DNAJA4 NLGN1	3.85e-04	195	17	3	4549_UP
Drug	Sulfadoxine [2447-57-6]; Up 200; 12.8uM; MCF7; HT_HG-U133A	EGFR DNAJA4 CREBBP	3.85e-04	195	17	3	3547_UP
Drug	Amprolium hydrochloride [137-88-2]; Up 200; 12.6uM; MCF7; HT_HG-U133A	EGFR NLGN1 CXXC4	3.91e-04	196	17	3	1479_UP
Drug	Dipyridamole [58-32-2]; Down 200; 8uM; PC3; HT_HG-U133A	CHRDL1 NOTCH1 NLGN1	3.91e-04	196	17	3	4656_DN
Drug	Finasteride [98319-26-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	EGFR KMT2A DNAJA4	3.91e-04	196	17	3	4766_DN
Drug	PNU-0230031 [267429-39-0]; Up 200; 10uM; PC3; HT_HG-U133A	DNAJA4 NLGN1 ZNF667	3.91e-04	196	17	3	3732_UP
Drug	Benfotiamine [22457-89-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	EGFR NLGN1 CXXC4	3.97e-04	197	17	3	3931_DN
Drug	Articaine hydrochloride [23964-57-0]; Up 200; 12.4uM; HL60; HT_HG-U133A	EGFR CREBBP CXXC4	3.97e-04	197	17	3	3138_UP
Drug	Cefaclor [70356-03-5]; Up 200; 10.4uM; PC3; HT_HG-U133A	KMT2A DNAJA4 CREBBP	3.97e-04	197	17	3	6622_UP
Drug	Gelsemine [509-15-9]; Up 200; 12.4uM; MCF7; HT_HG-U133A	DNAJA4 NLGN1 CXXC4	3.97e-04	197	17	3	2817_UP
Drug	Retrorsine [480-54-6]; Up 200; 11.4uM; HL60; HT_HG-U133A	KMT2A DNAJA4 CREBBP	3.97e-04	197	17	3	2129_UP
Drug	Sulfamethizole [144-82-1]; Up 200; 14.8uM; PC3; HT_HG-U133A	EGFR CHRDL1 CXXC4	3.97e-04	197	17	3	5798_UP
Drug	Dilazep dihydrochloride [20153-98-4]; Up 200; 6uM; MCF7; HT_HG-U133A	DNAJA4 CREBBP CXXC4	4.03e-04	198	17	3	2294_UP
Drug	Methionine sulfoximine (L) [15985-39-4]; Down 200; 22.2uM; PC3; HT_HG-U133A	DNAJA4 NOTCH1 ZNF667	4.03e-04	198	17	3	4070_DN
Drug	Chlorambucil [305-03-3]; Up 200; 13.2uM; PC3; HT_HG-U133A	CHRDL1 WIF1 ZNF667	4.03e-04	198	17	3	3788_UP
Drug	Deltaline [6836-11-9]; Up 200; 7.8uM; MCF7; HT_HG-U133A	KMT2A DNAJA4 CREBBP	4.03e-04	198	17	3	6026_UP
Drug	Methimazole [60-56-0]; Up 200; 35uM; MCF7; HT_HG-U133A	LMO1 DNAJA4 CREBBP	4.03e-04	198	17	3	3898_UP
Drug	Methiazole; Up 200; 15uM; MCF7; HT_HG-U133A	LMO1 DNAJA4 CREBBP	4.09e-04	199	17	3	3878_UP
Drug	Pirenzepine dihydrochloride [29868-97-1]; Up 200; 9.4uM; MCF7; HT_HG-U133A	LMO1 KMT2A CXXC4	4.09e-04	199	17	3	7226_UP
Drug	p-Chloromercuribenzoic Acid	LMO1 EGFR KMT2A CHRDL1 WIF1	4.14e-04	908	17	5	ctd:D020245
Drug	Flunisolide [3385-03-3]; Up 200; 9.2uM; MCF7; HT_HG-U133A	KMT2A DNAJA4 CREBBP	4.15e-04	200	17	3	6023_UP
Drug	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	CREBBP EP300	4.23e-04	41	17	2	ctd:D019307
Drug	AC1NAL8H	KMT2A CHRDL1	4.23e-04	41	17	2	CID004478772
Drug	N-methylmesoporphyrin	CREBBP EP300	4.44e-04	42	17	2	CID000444708
Drug	100 fM	EGFR CHRDL1	5.33e-04	46	17	2	CID000023998
Drug	AC1O745K	EGFR KMT2A	6.29e-04	50	17	2	CID006518178
Drug	MtT-S	EGFR WIF1	6.55e-04	51	17	2	CID000131613
Drug	AhR antagonist	EGFR EP300	6.81e-04	52	17	2	CID003091786
Drug	1,2-dioleoyloxy-3-(trimethylammonium)propane	EGFR PPP1R3G	7.34e-04	54	17	2	ctd:C070046
Disease	Bladder Neoplasm	EGFR KMT2A CREBBP EP300 NOTCH1	9.37e-09	140	16	5	C0005695
Disease	Malignant neoplasm of urinary bladder	EGFR KMT2A CREBBP EP300 NOTCH1	9.71e-09	141	16	5	C0005684
Disease	Small cell carcinoma of lung	EGFR KMT2A CREBBP EP300	1.79e-08	54	16	4	C0149925
Disease	Squamous cell carcinoma of esophagus	EGFR CREBBP EP300 NOTCH1	1.78e-07	95	16	4	C0279626
Disease	Menke-Hennekam syndrome	CREBBP EP300	2.76e-07	2	16	2	cv:C5681632
Disease	Rubinstein-Taybi syndrome (implicated_via_orthology)	CREBBP EP300	2.76e-07	2	16	2	DOID:1933 (implicated_via_orthology)
Disease	Rubinstein-Taybi syndrome	CREBBP EP300	2.76e-07	2	16	2	cv:C0035934
Disease	RUBINSTEIN-TAYBI SYNDROME 1	CREBBP EP300	2.76e-07	2	16	2	C4551859
Disease	Rubinstein-Taybi syndrome (is_implicated_in)	CREBBP EP300	2.76e-07	2	16	2	DOID:1933 (is_implicated_in)
Disease	RUBINSTEIN-TAYBI SYNDROME 1	CREBBP EP300	2.76e-07	2	16	2	180849
Disease	Rubinstein-Taybi syndrome due to CREBBP mutations	CREBBP EP300	2.76e-07	2	16	2	cv:C4551859
Disease	Rubinstein-Taybi Syndrome	CREBBP EP300	2.76e-07	2	16	2	C0035934
Disease	Squamous cell carcinoma	EGFR CREBBP EP300 NOTCH1	5.20e-07	124	16	4	C0007137
Disease	Carcinoma, Transitional Cell	KMT2A CREBBP EP300	1.38e-06	41	16	3	C0007138
Disease	Leukemia, T-Cell	LMO1 NOTCH1	2.75e-06	5	16	2	C0023492
Disease	alcohol use disorder (implicated_via_orthology)	EGFR CREBBP EP300 NOTCH1	3.16e-06	195	16	4	DOID:1574 (implicated_via_orthology)
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	KMT2A CREBBP EP300	4.62e-06	61	16	3	C1961102
Disease	Nasopharyngeal Neoplasms	EGFR WIF1	9.90e-06	9	16	2	C0027439
Disease	Cancer of Nasopharynx	EGFR WIF1	9.90e-06	9	16	2	C0238301
Disease	Colorectal Neoplasms	EGFR HHIP EP300 WIF1	1.27e-05	277	16	4	C0009404
Disease	acute myeloid leukemia (implicated_via_orthology)	KMT2A CREBBP	1.81e-05	12	16	2	DOID:9119 (implicated_via_orthology)
Disease	Adenoid Cystic Carcinoma	CREBBP EP300 NOTCH1	2.05e-05	100	16	3	C0010606
Disease	prostate cancer (is_marker_for)	KMT2A EP300 WIF1	7.72e-05	156	16	3	DOID:10283 (is_marker_for)
Disease	Craniofacial Abnormalities	EGFR EP300 NOTCH1	7.72e-05	156	16	3	C0376634
Disease	insomnia measurement	KMT2A EP300 NLGN1 CXXC4	7.91e-05	443	16	4	EFO_0007876
Disease	Leukemia, Myelocytic, Acute	KMT2A CREBBP EP300	1.05e-04	173	16	3	C0023467
Disease	intestinal cancer (implicated_via_orthology)	EGFR NOTCH1	1.35e-04	32	16	2	DOID:10155 (implicated_via_orthology)
Disease	Squamous cell carcinoma of lung	EGFR NOTCH1	1.35e-04	32	16	2	C0149782
Disease	cervical cancer	EGFR NOTCH1	1.53e-04	34	16	2	C4048328
Disease	Uterine Cervical Neoplasm	EGFR NOTCH1	1.62e-04	35	16	2	C0007873
Disease	Adenocarcinoma of lung (disorder)	EGFR CREBBP EP300	1.76e-04	206	16	3	C0152013
Disease	Breast adenocarcinoma	EP300 NOTCH1	2.23e-04	41	16	2	C0858252
Disease	Neoplasm of uncertain or unknown behavior of breast	EP300 NOTCH1	2.23e-04	41	16	2	C0496956
Disease	Anorectal Malformations	HHIP NLGN1	2.23e-04	41	16	2	C3495676
Disease	pulmonary fibrosis (biomarker_via_orthology)	EGFR NOTCH1	3.33e-04	50	16	2	DOID:3770 (biomarker_via_orthology)
Disease	response to trauma exposure	LMO1 WIF1	3.46e-04	51	16	2	EFO_0008483
Disease	Childhood Acute Lymphoblastic Leukemia	KMT2A NOTCH1	3.60e-04	52	16	2	C0023452
Disease	Squamous cell carcinoma of the head and neck	EGFR NOTCH1	3.60e-04	52	16	2	C1168401
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	LMO1 NOTCH1	3.74e-04	53	16	2	C1961099
Disease	Diffuse Large B-Cell Lymphoma	CREBBP EP300	4.03e-04	55	16	2	C0079744
Disease	Colorectal Carcinoma	EGFR HHIP EP300 WIF1	4.60e-04	702	16	4	C0009402
Disease	Hereditary Diffuse Gastric Cancer	EGFR KMT2A WIF1	4.93e-04	293	16	3	C1708349
Disease	Stomach Neoplasms	EGFR KMT2A WIF1	5.13e-04	297	16	3	C0038356
Disease	Malignant neoplasm of stomach	EGFR KMT2A WIF1	5.28e-04	300	16	3	C0024623
Disease	breast carcinoma (is_marker_for)	EGFR EP300	5.79e-04	66	16	2	DOID:3459 (is_marker_for)
Disease	Endometrial Carcinoma	EGFR EP300	6.89e-04	72	16	2	C0476089
Disease	Esophageal Neoplasms	EGFR WIF1	8.08e-04	78	16	2	C0014859
Disease	Malignant neoplasm of esophagus	EGFR WIF1	8.08e-04	78	16	2	C0546837
Disease	Glioblastoma	EGFR NOTCH1	8.29e-04	79	16	2	C0017636
Disease	Giant Cell Glioblastoma	EGFR NOTCH1	9.36e-04	84	16	2	C0334588
Disease	acute myeloid leukemia (is_implicated_in)	KMT2A CREBBP	9.36e-04	84	16	2	DOID:9119 (is_implicated_in)
Disease	Adenocarcinoma of large intestine	EGFR EP300	1.22e-03	96	16	2	C1319315
Disease	S-warfarin measurement	EGFR NLGN1	1.25e-03	97	16	2	EFO_0803323
Disease	Pancreatic Neoplasm	EGFR EP300	1.32e-03	100	16	2	C0030297
Disease	Malignant neoplasm of pancreas	EGFR EP300	1.38e-03	102	16	2	C0346647
Disease	platelet crit	CXXC5 EGFR CHRDL1 DNAJA4	1.44e-03	952	16	4	EFO_0007985
Disease	urinary bladder cancer (is_marker_for)	EGFR WIF1	1.51e-03	107	16	2	DOID:11054 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CKRKTNGGCPICKQL	EP300	1771	Q09472
KGCKRKTNGGCPVCK	CREBBP	1806	Q92793
VGGKKGSVEKCPLCK	DNAJA4	141	Q8WW22
QPKGKQKGCAGCNRK	LMO1	16	P25800
CKGKPCKNGGTCAVA	NOTCH1	1311	P46531
ECARKPGKKICRKGG	NLGN1	171	Q8N2Q7
GKKKRKRCGMCAPCR	CXXC5	256	Q7LFL8
KKPSGLCPKCGKGKH	ERVK-5	576	Q9HDB9
DGVRKCKKCEGPCRK	EGFR	321	P00533
PQKIDGKCCKVCPGK	CHRDL1	311	Q9BU40
GKCCKVCPGKKAKEL	CHRDL1	316	Q9BU40
PAKKKRKRCGVCVPC	CXXC4	131	Q9H2H0
KPKFGGRNIKKQCCK	KMT2A	1176	Q03164
KKVGKAPKSACGVCP	RPL34	36	P49207
DAQLGPGGCCAKCKK	PPP1R3G	116	B7ZBB8
PGGCCAKCKKRVQFA	PPP1R3G	121	B7ZBB8
GGVCVRPNKCLCKKG	HHIP	646	Q96QV1
KGHSGKKPLKCNDCG	ZNF667	136	Q5HYK9
HTGKKPFKCKECGKG	ZNF620	246	Q6ZNG0
PCRNGGKCIGKSKCK	WIF1	281	Q9Y5W5