Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnatural killer cell lectin-like receptor binding

ULBP2 RAET1L MICB

4.15e-0717183GO:0046703
GeneOntologyMolecularFunctioncholesterol binding

PROM1 SCAP

1.23e-0358182GO:0015485
GeneOntologyMolecularFunctionsterol binding

PROM1 SCAP

1.84e-0371182GO:0032934
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

ULBP2 RAET1L MICB

3.10e-0716183GO:0002486
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

ULBP2 RAET1L MICB

3.77e-0717183GO:0002484
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen via MHC class Ib

ULBP2 RAET1L MICB

3.77e-0717183GO:0002476
GeneOntologyBiologicalProcessantigen processing and presentation of peptide antigen via MHC class Ib

ULBP2 RAET1L MICB

4.52e-0718183GO:0002428
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen via MHC class I

ULBP2 RAET1L MICB

9.78e-0723183GO:0019885
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous peptide antigen

ULBP2 RAET1L MICB

1.27e-0625183GO:0002483
GeneOntologyBiologicalProcessantigen processing and presentation via MHC class Ib

ULBP2 RAET1L MICB

1.27e-0625183GO:0002475
GeneOntologyBiologicalProcessantigen processing and presentation of endogenous antigen

ULBP2 RAET1L MICB

2.72e-0632183GO:0019883
GeneOntologyBiologicalProcessantigen processing and presentation of peptide antigen via MHC class I

ULBP2 RAET1L MICB

5.83e-0641183GO:0002474
GeneOntologyBiologicalProcesspositive regulation of T cell mediated cytotoxicity

ULBP2 RAET1L MICB

6.27e-0642183GO:0001916
GeneOntologyBiologicalProcessregulation of T cell mediated cytotoxicity

ULBP2 RAET1L MICB

1.27e-0553183GO:0001914
GeneOntologyBiologicalProcesssusceptibility to natural killer cell mediated cytotoxicity

ULBP2 RAET1L

2.58e-059182GO:0042271
GeneOntologyBiologicalProcessT cell mediated cytotoxicity

ULBP2 RAET1L MICB

2.95e-0570183GO:0001913
GeneOntologyBiologicalProcesspositive regulation of T cell mediated immunity

ULBP2 RAET1L MICB

3.48e-0574183GO:0002711
GeneOntologyBiologicalProcessantigen processing and presentation of peptide antigen

ULBP2 RAET1L MICB

3.77e-0576183GO:0048002
GeneOntologyBiologicalProcesspositive regulation of leukocyte mediated cytotoxicity

ULBP2 RAET1L MICB

4.23e-0579183GO:0001912
GeneOntologyBiologicalProcesspositive regulation of cell killing

ULBP2 RAET1L MICB

5.85e-0588183GO:0031343
GeneOntologyBiologicalProcessregulation of T cell mediated immunity

ULBP2 RAET1L MICB

1.17e-04111183GO:0002709
GeneOntologyBiologicalProcessregulation of leukocyte mediated cytotoxicity

ULBP2 RAET1L MICB

1.62e-04124183GO:0001910
GeneOntologyBiologicalProcesscellular response to exogenous dsRNA

ULBP2 RAET1L

1.64e-0422182GO:0071360
GeneOntologyBiologicalProcessantigen processing and presentation

ULBP2 RAET1L MICB

2.27e-04139183GO:0019882
GeneOntologyBiologicalProcessregulation of cell killing

ULBP2 RAET1L MICB

2.68e-04147183GO:0031341
GeneOntologyBiologicalProcesscellular response to dsRNA

ULBP2 RAET1L

2.68e-0428182GO:0071359
GeneOntologyBiologicalProcesspositive regulation of response to tumor cell

ULBP2 RAET1L

2.68e-0428182GO:0002836
GeneOntologyBiologicalProcesspositive regulation of immune response to tumor cell

ULBP2 RAET1L

2.68e-0428182GO:0002839
GeneOntologyBiologicalProcesspositive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

ULBP2 RAET1L MICB

2.84e-04150183GO:0002824
GeneOntologyBiologicalProcesspositive regulation of lymphocyte mediated immunity

ULBP2 RAET1L MICB

2.84e-04150183GO:0002708
GeneOntologyBiologicalProcesspositive regulation of adaptive immune response

ULBP2 RAET1L MICB

3.37e-04159183GO:0002821
GeneOntologyBiologicalProcessT cell mediated immunity

ULBP2 RAET1L MICB

3.62e-04163183GO:0002456
GeneOntologyBiologicalProcesspositive regulation of natural killer cell activation

ULBP2 RAET1L

4.21e-0435182GO:0032816
GeneOntologyBiologicalProcesspositive regulation of leukocyte mediated immunity

ULBP2 RAET1L MICB

4.46e-04175183GO:0002705
GeneOntologyBiologicalProcessleukocyte mediated cytotoxicity

ULBP2 RAET1L MICB

5.41e-04187183GO:0001909
GeneOntologyBiologicalProcesspositive regulation of natural killer cell mediated cytotoxicity

ULBP2 RAET1L

5.50e-0440182GO:0045954
GeneOntologyBiologicalProcesspositive regulation of macrophage activation

ULBP2 RAET1L

6.07e-0442182GO:0043032
GeneOntologyBiologicalProcesspositive regulation of natural killer cell mediated immunity

ULBP2 RAET1L

6.66e-0444182GO:0002717
GeneOntologyBiologicalProcessregulation of immune response to tumor cell

ULBP2 RAET1L

8.26e-0449182GO:0002837
GeneOntologyBiologicalProcessregulation of response to tumor cell

ULBP2 RAET1L

8.60e-0450182GO:0002834
GeneOntologyBiologicalProcessregulation of lymphocyte mediated immunity

ULBP2 RAET1L MICB

1.01e-03232183GO:0002706
GeneOntologyBiologicalProcessresponse to exogenous dsRNA

ULBP2 RAET1L

1.04e-0355182GO:0043330
GeneOntologyBiologicalProcessregulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

ULBP2 RAET1L MICB

1.05e-03235183GO:0002822
GeneOntologyBiologicalProcessimmune response to tumor cell

ULBP2 RAET1L

1.08e-0356182GO:0002418
GeneOntologyBiologicalProcessregulation of natural killer cell activation

ULBP2 RAET1L

1.28e-0361182GO:0032814
GeneOntologyBiologicalProcessregulation of adaptive immune response

ULBP2 RAET1L MICB

1.28e-03252183GO:0002819
GeneOntologyBiologicalProcessresponse to dsRNA

ULBP2 RAET1L

1.36e-0363182GO:0043331
GeneOntologyBiologicalProcesspositive regulation of nitric oxide biosynthetic process

ULBP2 RAET1L

1.45e-0365182GO:0045429
GeneOntologyBiologicalProcesspositive regulation of nitric oxide metabolic process

ULBP2 RAET1L

1.54e-0367182GO:1904407
GeneOntologyBiologicalProcessresponse to tumor cell

ULBP2 RAET1L

1.72e-0371182GO:0002347
GeneOntologyBiologicalProcessregulation of natural killer cell mediated cytotoxicity

ULBP2 RAET1L

1.97e-0376182GO:0042269
GeneOntologyBiologicalProcessregulation of response to biotic stimulus

ULBP2 RAET1L MICB RNF144A

2.02e-03643184GO:0002831
GeneOntologyBiologicalProcessregulation of natural killer cell mediated immunity

ULBP2 RAET1L

2.18e-0380182GO:0002715
GeneOntologyBiologicalProcessregulation of macrophage activation

ULBP2 RAET1L

2.24e-0381182GO:0043030
GeneOntologyBiologicalProcesscell killing

ULBP2 RAET1L MICB

2.26e-03307183GO:0001906
GeneOntologyBiologicalProcessregulation of leukocyte mediated immunity

ULBP2 RAET1L MICB

2.30e-03309183GO:0002703
GeneOntologyBiologicalProcesspositive regulation of immune effector process

ULBP2 RAET1L MICB

2.47e-03317183GO:0002699
GeneOntologyBiologicalProcessregulation of nitric oxide biosynthetic process

ULBP2 RAET1L

3.19e-0397182GO:0045428
GeneOntologyBiologicalProcessregulation of nitric oxide metabolic process

ULBP2 RAET1L

3.38e-03100182GO:0080164
GeneOntologyBiologicalProcesspositive regulation of type II interferon production

ULBP2 RAET1L

3.59e-03103182GO:0032729
GeneOntologyBiologicalProcessnatural killer cell mediated cytotoxicity

ULBP2 RAET1L

3.72e-03105182GO:0042267
GeneOntologyBiologicalProcessnatural killer cell mediated immunity

ULBP2 RAET1L

4.01e-03109182GO:0002228
GeneOntologyBiologicalProcessdefense response to symbiont

CYBB ULBP2 RAET1L MICB RNF144A

4.04e-031286185GO:0140546
GeneOntologyBiologicalProcessnitric oxide biosynthetic process

ULBP2 RAET1L

4.22e-03112182GO:0006809
GeneOntologyBiologicalProcessnitric oxide metabolic process

ULBP2 RAET1L

4.91e-03121182GO:0046209
GeneOntologyBiologicalProcessreactive nitrogen species metabolic process

ULBP2 RAET1L

5.07e-03123182GO:2001057
GeneOntologyBiologicalProcessnatural killer cell activation

ULBP2 RAET1L

5.15e-03124182GO:0030101
GeneOntologyBiologicalProcesspositive regulation of immune response

ULBP2 RAET1L MICB RNF144A

5.40e-03845184GO:0050778
GeneOntologyBiologicalProcesspositive regulation of innate immune response

ULBP2 RAET1L RNF144A

5.45e-03420183GO:0045089
GeneOntologyBiologicalProcessdefense response to other organism

CYBB ULBP2 RAET1L MICB RNF144A

5.94e-031407185GO:0098542
GeneOntologyBiologicalProcessmacrophage activation

ULBP2 RAET1L

6.52e-03140182GO:0042116
GeneOntologyBiologicalProcesslymphocyte mediated immunity

ULBP2 RAET1L MICB

6.56e-03449183GO:0002449
GeneOntologyBiologicalProcesspositive regulation of response to biotic stimulus

ULBP2 RAET1L RNF144A

6.64e-03451183GO:0002833
GeneOntologyBiologicalProcessadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

ULBP2 RAET1L MICB

7.09e-03462183GO:0002460
GeneOntologyCellularComponentexternal side of plasma membrane

RTN4RL2 ULBP2 RAET1L MICB

8.71e-04519184GO:0009897
GeneOntologyCellularComponentcell surface

RTN4RL2 ULBP2 PROM1 RAET1L MICB

2.01e-031111185GO:0009986
DomainMHC_I_a_a1/a2

ULBP2 RAET1L MICB

9.89e-0721183IPR001039
DomainMHC_I

ULBP2 RAET1L MICB

9.89e-0721183PF00129
Domain-

ULBP2 RAET1L MICB

1.50e-06241833.30.500.10
DomainMHC_I-like_Ag-recog

ULBP2 RAET1L MICB

1.50e-0624183IPR011161
DomainMHC_I/II-like_Ag-recog

ULBP2 RAET1L MICB

6.21e-0638183IPR011162
DomainIG_MHC

ULBP2 RAET1L

1.50e-0360182PS00290
DomainZnf_RING_CS

TRIM71 RNF144A

1.06e-02163182IPR017907
PathwayREACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS

RTN4RL2 ULBP2 RAET1L

1.19e-0493153M26985
PathwayKEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY

ULBP2 RAET1L MICB

3.75e-04137153M5669
Pubmed

Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.

ULBP2 RAET1L MICB

2.33e-09618310894171
Pubmed

Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity.

ULBP2 MICB

7.59e-07318212782710
Pubmed

The RNA binding protein IMP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULPB2 and MICB.

ULBP2 MICB

7.59e-07318226982091
Pubmed

The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia.

ULBP2 MICB

7.59e-07318220428196
Pubmed

Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis.

ULBP2 MICB

7.59e-07318218791713
Pubmed

Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.

ULBP2 RAET1L

7.59e-07318225212604
Pubmed

Vesicular stomatitis virus infection promotes immune evasion by preventing NKG2D-ligand surface expression.

ULBP2 MICB

7.59e-07318221857986
Pubmed

Murine NKG2D ligands: "double, double toil and trouble".

ULBP2 RAET1L

1.52e-06418219081632
Pubmed

NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules.

ULBP2 RAET1L

1.52e-06418212756263
Pubmed

Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: a novel cDNA family encodes cell surface proteins sharing partial homology with MHC class I molecules.

ULBP2 RAET1L

1.52e-0641828882725
Pubmed

Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity.

ULBP2 MICB

1.52e-06418225775242
Pubmed

Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms.

ULBP2 RAET1L

1.52e-06418220166740
Pubmed

Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin.

ULBP2 RAET1L

1.52e-06418212421908
Pubmed

Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain.

ULBP2 RAET1L

2.53e-0651828982867
Pubmed

MULT1E/mIL-12: a novel bifunctional protein for natural killer cell activation.

ULBP2 RAET1L

2.53e-06518224572784
Pubmed

Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais.

ULBP2 RAET1L

3.79e-06618219688209
Pubmed

Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D.

ULBP2 RAET1L

3.79e-06618211825567
Pubmed

The NKG2D ligands RAE-1δ and RAE-1ε differ with respect to their receptor affinity, expression profiles and transcriptional regulation.

ULBP2 RAET1L

3.79e-06618220976056
Pubmed

Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.

ULBP2 RAET1L

3.79e-06618220219610
Pubmed

Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family.

ULBP2 MICB

3.79e-06618211491531
Pubmed

Ligands for murine NKG2D display heterogeneous binding behavior.

ULBP2 RAET1L

3.79e-06618211857333
Pubmed

NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery.

ULBP2 RAET1L

5.30e-06718225583577
Pubmed

A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.

ULBP2 RAET1L

5.30e-06718228559451
Pubmed

The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60.

ULBP2 RAET1L

5.30e-06718216831899
Pubmed

Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase.

ULBP2 RAET1L

5.30e-06718220870941
Pubmed

Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain.

PROM1 TRIM71

5.30e-06718225883935
Pubmed

Critical role of the NKG2D receptor for NK cell-mediated control and immune escape of B-cell lymphoma.

ULBP2 RAET1L

5.30e-06718226151313
Pubmed

NKG2D and Its Ligand MULT1 Contribute to Disease Progression in a Mouse Model of Multiple Sclerosis.

ULBP2 RAET1L

5.30e-06718230787931
Pubmed

ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.

ULBP2 MICB

5.30e-06718211239445
Pubmed

Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D.

ULBP2 RAET1L

5.30e-06718212370332
Pubmed

A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity.

ULBP2 RAET1L

7.07e-06818212645935
Pubmed

Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells.

ULBP2 RAET1L

9.09e-06918223136011
Pubmed

Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor.

ULBP2 RAET1L

9.09e-06918214764662
Pubmed

A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3.

ULBP2 RAET1L

1.14e-051018211827464
Pubmed

Cell Surface Downregulation of NK Cell Ligands by Patient-Derived HIV-1 Vpu and Nef Alleles.

ULBP2 RAET1L

1.39e-051118226656785
Pubmed

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

TRIM71 MICB

1.09e-043018221946350
Pubmed

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

RNF144A SCAP

2.05e-04411828724849
InteractionRAET1L interactions

ULBP2 RAET1L

5.84e-0513182int:RAET1L
CytobandEnsembl 112 genes in cytogenetic band chr6q25

ULBP2 RAET1L

1.87e-03164182chr6q25
GeneFamilyRing finger proteins

TRIM71 RNF144A

1.61e-0227513258
DrugChloroprene

CYBB GALNT15 PROM1 SLC16A12 RNF144A MRGPRF FETUB

4.48e-051348187ctd:D002737
Drugeckol

CYBB PROM1

4.58e-0513182ctd:C060311
Diseaselevel of UL16-binding protein 6 in blood serum

ULBP2 RAET1L

3.51e-072182OBA_2043185
Diseasebrain aneurysm

PROM1 PLB1 RNF144A

4.28e-05113183EFO_0003870
Diseasepulmonary function measurement, forced expiratory volume

TRIM71 MICB

2.31e-0437182EFO_0003892, EFO_0004314
DiseasePolydactyly

LMBR1 PROM1

2.29e-03117182C0152427
Diseasekeratinocyte carcinoma

ULBP2 RAET1L

2.33e-03118182EFO_0010176

Protein segments in the cluster

PeptideGeneStartEntry
LPLCLACLVCVFLLM

ANO8

361

Q9HCE9
LLALPLAAPSCPMLC

RTN4RL2

21

Q86UN3
ICLLCKEMCGSPAPL

TRIM71

11

Q2Q1W2
CISLMGCLLLLLCTP

LMBR1

196

Q8WVP7
LLLILAPLLLLLCCC

DSG4

641

Q86SJ6
MGLLLPLALCILVLC

FETUB

1

Q9UGM5
PCRLQFLLLLLMLGC

GALNT15

11

Q8N3T1
AMPCFVIIIILCVPC

MICB

316

Q29980
PFLLLATPFVLCCKC

RNF144A

266

P50876
PAACLNFNCMLILLP

CYBB

56

P04839
CILACCYPLLKLPLP

SCAP

36

Q12770
GLCYLCLPMLQSLPL

SLC16A12

361

Q6ZSM3
LGILLFLLCCPLMVL

MRGPRF

201

Q96AM1
FLLCCPLMVLPCLAL

MRGPRF

206

Q96AM1
LCCVLGLLFIILMPL

PROM1

111

O43490
YCPRMILRSLCPCVL

PLB1

571

Q6P1J6
MSCPVPACCALLLVL

SGSH

1

P51688
PICPGLICCLLTCLL

PP632

66

Q6XCG6
LCCLLIILPCFILPG

RAET1L

231

Q5VY80
LCCLLIILPCFILPG

ULBP2

231

Q9BZM5