Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG-protein beta/gamma-subunit complex binding

GNA11 GNAI3 GNAL GNAQ GNAT2

8.06e-0925575GO:0031683
GeneOntologyMolecularFunctionactivin receptor activity

TGFBR1 ACVR2A ACVR2B

1.83e-069573GO:0017002
GeneOntologyMolecularFunctionactivin binding

TGFBR1 ACVR2A ACVR2B

4.76e-0612573GO:0048185
GeneOntologyMolecularFunctiontransmembrane receptor protein serine/threonine kinase activity

TGFBR1 ACVR2A ACVR2B

2.43e-0520573GO:0004675
GeneOntologyMolecularFunctionalkylglycerophosphoethanolamine phosphodiesterase activity

GNA11 GNAQ

7.96e-055572GO:0047391
GeneOntologyMolecularFunctioninhibin binding

ACVR2A ACVR2B

7.96e-055572GO:0034711
GeneOntologyMolecularFunctionoleate transmembrane transporter activity

SLC27A1 SLC27A2

1.19e-046572GO:1901480
GeneOntologyMolecularFunctionvery long-chain fatty acid-CoA ligase activity

SLC27A1 SLC27A2

3.55e-0410572GO:0031957
GeneOntologyMolecularFunctionG protein-coupled receptor binding

GNA11 GNAI3 GNAL GNAQ GNAT2 ARAP1

3.89e-04337576GO:0001664
GeneOntologyMolecularFunctionarachidonate-CoA ligase activity

SLC27A1 SLC27A2

4.33e-0411572GO:0047676
GeneOntologyMolecularFunctionlong-chain fatty acid-CoA ligase activity

SLC27A1 SLC27A2

8.21e-0415572GO:0004467
GeneOntologyMolecularFunctionlong-chain fatty acid transmembrane transporter activity

SLC27A1 SLC27A2

1.19e-0318572GO:0005324
GeneOntologyMolecularFunctionU6 snRNA binding

PRPF4 LSM4

1.19e-0318572GO:0017070
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

TGFBR1 ACVR2A ACVR2B LMTK3 STK35 MAP3K19

1.66e-03446576GO:0004674
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

TGFBR1 ACVR2A ACVR2B

1.85e-0385573GO:0019199
GeneOntologyMolecularFunctionfatty acid transmembrane transporter activity

SLC27A1 SLC27A2

1.95e-0323572GO:0015245
GeneOntologyMolecularFunctiontransforming growth factor beta binding

TGFBR1 ACVR2B

2.49e-0326572GO:0050431
GeneOntologyMolecularFunctionfatty acid ligase activity

SLC27A1 SLC27A2

2.49e-0326572GO:0015645
GeneOntologyMolecularFunctionenzyme activator activity

SLC27A1 GNAQ OCRL LTF ACVR2B ARAP1 SYNGAP1

2.54e-03656577GO:0008047
GeneOntologyMolecularFunctionCoA-ligase activity

SLC27A1 SLC27A2

2.68e-0327572GO:0016405
GeneOntologyMolecularFunctionGTPase activity

GNA11 GNAI3 GNAL GNAQ GNAT2

2.85e-03341575GO:0003924
GeneOntologyMolecularFunctionacid-thiol ligase activity

SLC27A1 SLC27A2

3.53e-0331572GO:0016878
GeneOntologyBiologicalProcessG protein-coupled dopamine receptor signaling pathway

GNA11 GNAI3 GNAL GNAQ

7.03e-0644584GO:0007212
GeneOntologyBiologicalProcesscellular response to dopamine

GNA11 GNAI3 GNAL GNAQ

3.15e-0564584GO:1903351
GeneOntologyBiologicalProcessresponse to dopamine

GNA11 GNAI3 GNAL GNAQ

3.56e-0566584GO:1903350
GeneOntologyBiologicalProcesscellular response to monoamine stimulus

GNA11 GNAI3 GNAL GNAQ

4.01e-0568584GO:0071868
GeneOntologyBiologicalProcesscellular response to catecholamine stimulus

GNA11 GNAI3 GNAL GNAQ

4.01e-0568584GO:0071870
GeneOntologyBiologicalProcessskeletal system development

PAPPA2 TGFBR1 DHRS3 ASH1L GNA11 GNAQ LTF ACVR2A ACVR2B

5.08e-05615589GO:0001501
GeneOntologyBiologicalProcessresponse to catecholamine

GNA11 GNAI3 GNAL GNAQ

5.30e-0573584GO:0071869
GeneOntologyBiologicalProcessresponse to monoamine

GNA11 GNAI3 GNAL GNAQ

5.59e-0574584GO:0071867
GeneOntologyBiologicalProcessmelanocyte differentiation

TYRP1 GNA11 GNAQ

7.32e-0529583GO:0030318
GeneOntologyBiologicalProcessregulation of melanocyte differentiation

GNA11 GNAQ

1.62e-047582GO:0045634
GeneOntologyBiologicalProcesspigment cell differentiation

TYRP1 GNA11 GNAQ

1.94e-0440583GO:0050931
GeneOntologyBiologicalProcesspositive regulation of activin receptor signaling pathway

ACVR2A ACVR2B

2.15e-048582GO:0032927
GeneOntologyBiologicalProcessphospholipase C-activating dopamine receptor signaling pathway

GNA11 GNAQ

2.76e-049582GO:0060158
GeneOntologyBiologicalProcessregulation of pigment cell differentiation

GNA11 GNAQ

2.76e-049582GO:0050932
GeneOntologyBiologicalProcesspositive regulation of bone mineralization

LTF ACVR2A ACVR2B

3.55e-0449583GO:0030501
GeneOntologyBiologicalProcesspigmentation

TYRP1 GNA11 GNAQ GNAT2

4.23e-04125584GO:0043473
GeneOntologyBiologicalProcessphototransduction

GNA11 GNAQ GNAT2

4.47e-0453583GO:0007602
GeneOntologyBiologicalProcession channel modulating, G protein-coupled receptor signaling pathway

GNA11 GNAQ

5.04e-0412582GO:0099105
GeneOntologyBiologicalProcessdetection of visible light

GNA11 GNAQ GNAT2

5.54e-0457583GO:0009584
GeneOntologyBiologicalProcesspost-embryonic development

TGFBR1 ASH1L GNAQ ACVR2B

5.66e-04135584GO:0009791
GeneOntologyBiologicalProcessdevelopmental pigmentation

TYRP1 GNA11 GNAQ

5.83e-0458583GO:0048066
GeneOntologyBiologicalProcessphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

GNA11 GNAQ

5.94e-0413582GO:0007207
GeneOntologyBiologicalProcessendothelin receptor signaling pathway

GNA11 GNAQ

5.94e-0413582GO:0086100
GeneOntologyBiologicalProcessactivin receptor signaling pathway

TGFBR1 ACVR2A ACVR2B

6.44e-0460583GO:0032924
GeneOntologyBiologicalProcesspositive regulation of biomineral tissue development

LTF ACVR2A ACVR2B

6.44e-0460583GO:0070169
GeneOntologyCellularComponentheterotrimeric G-protein complex

GNA11 GNAI3 GNAL GNAQ GNAT2

3.84e-0835575GO:0005834
GeneOntologyCellularComponentGTPase complex

GNA11 GNAI3 GNAL GNAQ GNAT2

8.76e-0841575GO:1905360
GeneOntologyCellularComponentactivin receptor complex

TGFBR1 ACVR2A ACVR2B

3.82e-076573GO:0048179
GeneOntologyCellularComponentextrinsic component of cytoplasmic side of plasma membrane

GNA11 GNAI3 GNAL GNAQ GNAT2

4.33e-0756575GO:0031234
GeneOntologyCellularComponentplasma membrane protein complex

TGFBR1 KCNQ5 KCNQ2 GNA11 CACNA1I GNAI3 GNAL GNAQ ACVR2A GNAT2 ACVR2B

7.43e-067855711GO:0098797
GeneOntologyCellularComponentphotoreceptor outer segment

DHRS3 GNA11 GNAQ OCRL GNAT2

1.30e-05111575GO:0001750
GeneOntologyCellularComponentextrinsic component of plasma membrane

GNA11 GNAI3 GNAL GNAQ GNAT2

3.58e-05137575GO:0019897
GeneOntologyCellularComponentphotoreceptor cell cilium

DHRS3 GNA11 GNAQ OCRL GNAT2

3.84e-05139575GO:0097733
GeneOntologyCellularComponent9+0 non-motile cilium

DHRS3 GNA11 GNAQ OCRL GNAT2

6.06e-05153575GO:0097731
GeneOntologyCellularComponentcytoplasmic side of plasma membrane

GNA11 GNAI3 GNAL GNAQ GNAT2

1.48e-04185575GO:0009898
GeneOntologyCellularComponentnon-motile cilium

DHRS3 GNA11 GNAQ OCRL GNAT2

1.94e-04196575GO:0097730
GeneOntologyCellularComponentcytoplasmic side of membrane

GNA11 GNAI3 GNAL GNAQ GNAT2

4.06e-04230575GO:0098562
GeneOntologyCellularComponentextrinsic component of membrane

GNA11 GNAI3 GNAL GNAQ GNAT2

4.06e-04230575GO:0019898
GeneOntologyCellularComponentmembrane protein complex

TGFBR1 KCNQ5 KCNQ2 GNA11 CACNA1I GNAI3 GNAL GNAQ ACVR2A GNAT2 ACVR2B MICU2

6.04e-0414985712GO:0098796
GeneOntologyCellularComponentphotoreceptor outer segment membrane

DHRS3 GNAT2

1.21e-0319572GO:0042622
GeneOntologyCellularComponentP-body

ZC3H12D LSM4 TRIM21

2.73e-03102573GO:0000932
GeneOntologyCellularComponentcaveola

TGFBR1 SLC27A1 GNAQ

3.46e-03111573GO:0005901
GeneOntologyCellularComponentcation channel complex

KCNQ5 KCNQ2 CACNA1I MICU2

3.86e-03235574GO:0034703
MousePhenoabnormal afterhyperpolarization

KCNQ5 KCNQ2 CACNA1I GNAQ

4.91e-0717554MP:0003412
DomainG-alpha

GNA11 GNAI3 GNAL GNAQ GNAT2

1.03e-0916585PF00503
DomainGproteinA_insert

GNA11 GNAI3 GNAL GNAQ GNAT2

1.03e-0916585IPR011025
Domain-

GNA11 GNAI3 GNAL GNAQ GNAT2

1.03e-09165851.10.400.10
DomainG_alpha

GNA11 GNAI3 GNAL GNAQ GNAT2

1.03e-0916585SM00275
DomainGprotein_alpha_su

GNA11 GNAI3 GNAL GNAQ GNAT2

1.46e-0917585IPR001019
DomainActivin_recp

TGFBR1 ACVR2A ACVR2B

3.36e-0610583IPR000472
DomainActivin_recp

TGFBR1 ACVR2A ACVR2B

3.36e-0610583PF01064
DomainTGFB_receptor

TGFBR1 ACVR2A ACVR2B

6.13e-0612583IPR000333
DomainK_chnl_volt-dep_KCNQ2

KCNQ5 KCNQ2

9.48e-062582IPR003947
DomainGprotein_alpha_Q

GNA11 GNAQ

5.66e-054582IPR000654
DomainZnf_B-box_chordata

TRIM21 TRIM7

5.66e-054582IPR020457
DomainK_chnl_volt-dep_KCNQ

KCNQ5 KCNQ2

9.42e-055582IPR003937
DomainK_chnl_volt-dep_KCNQ_C

KCNQ5 KCNQ2

9.42e-055582IPR013821
DomainKCNQ_channel

KCNQ5 KCNQ2

9.42e-055582PF03520
DomainGprotein_alpha_I

GNAI3 GNAT2

2.62e-048582IPR001408
DomainAMP-bd_C

SLC27A1 SLC27A2

1.25e-0317582IPR025110
DomainAMP-binding_C

SLC27A1 SLC27A2

1.25e-0317582PF13193
DomainRho_GTPase_activation_prot

OCRL ARAP1 SYNGAP1

2.59e-0388583IPR008936
DomainPROTEIN_KINASE_ATP

TGFBR1 ACVR2A ACVR2B LMTK3 STK35 MAP3K19

2.93e-03459586PS00107
DomainAMP-binding_CS

SLC27A1 SLC27A2

2.94e-0326582IPR020845
DomainAMP_BINDING

SLC27A1 SLC27A2

3.40e-0328582PS00455
DomainAMP-binding

SLC27A1 SLC27A2

3.90e-0330582PF00501
DomainAMP-dep_Synth/Lig

SLC27A1 SLC27A2

3.90e-0330582IPR000873
DomainPROTEIN_KINASE_DOM

TGFBR1 ACVR2A ACVR2B LMTK3 STK35 MAP3K19

4.16e-03493586PS50011
DomainVG_K_chnl

KCNQ5 KCNQ2

4.70e-0333582IPR028325
DomainConA-like_dom

PAPPA2 CELSR3 TRIM21 TRIM7

4.76e-03219584IPR013320
DomainSer/Thr_kinase_AS

TGFBR1 ACVR2A ACVR2B STK35 MAP3K19

4.96e-03357585IPR008271
DomainPROTEIN_KINASE_ST

TGFBR1 ACVR2A ACVR2B STK35 MAP3K19

5.26e-03362585PS00108
DomainIon_trans_dom

KCNQ5 KCNQ2 CACNA1I

5.35e-03114583IPR005821
DomainIon_trans

KCNQ5 KCNQ2 CACNA1I

5.35e-03114583PF00520
DomainRA

RASSF1 ARAP1

5.58e-0336582PF00788
DomainRA

RASSF1 ARAP1

5.89e-0337582PS50200
DomainPkinase

TGFBR1 ACVR2A ACVR2B STK35 MAP3K19

6.50e-03381585PF00069
DomainRA_dom

RASSF1 ARAP1

6.85e-0340582IPR000159
DomainPRY

TRIM21 TRIM7

7.54e-0342582PF13765
DomainBTB-kelch_protein

KBTBD2 KLHL33

7.89e-0343582IPR017096
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

GNA11 GNAI3 GNAL GNAQ

8.92e-0639484MM14496
PathwayPID_ER_NONGENOMIC_PATHWAY

GNA11 GNAI3 GNAL GNAQ

9.88e-0640484M41
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

GNA11 GNAI3 GNAL GNAQ

3.30e-0554484M26911
PathwayPID_S1P_META_PATHWAY

GNA11 GNAI3 GNAQ

4.72e-0521483M155
PathwayPID_ENDOTHELIN_PATHWAY

GNA11 GNAI3 GNAL GNAQ

6.08e-0563484M8
PathwayPID_S1P_S1P2_PATHWAY

GNA11 GNAI3 GNAQ

7.13e-0524483M268
PathwayPID_ALK1_PATHWAY

TGFBR1 ACVR2A ACVR2B

9.12e-0526483M185
PathwayREACTOME_OPIOID_SIGNALLING

GNA11 GNAI3 GNAL GNAQ

9.72e-0571484MM14491
PathwayPID_S1P_S1P3_PATHWAY

GNA11 GNAI3 GNAQ

1.27e-0429483M55
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

GNA11 GNAQ

1.69e-046482M47548
PathwayREACTOME_SIGNAL_AMPLIFICATION

GNA11 GNAI3 GNAQ

1.88e-0433483MM15020
PathwayREACTOME_SIGNAL_AMPLIFICATION

GNA11 GNAI3 GNAQ

1.88e-0433483M9379
PathwayREACTOME_OPIOID_SIGNALLING

GNA11 GNAI3 GNAL GNAQ

2.44e-0490484M6467
PathwayWP_G_PROTEIN_SIGNALING_PATHWAYS

GNA11 GNAI3 GNAL GNAQ

2.44e-0490484MM15882
PathwayWP_G_PROTEIN_SIGNALING

GNA11 GNAI3 GNAL GNAQ

2.54e-0491484M39426
PathwayREACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION

GNA11 GNAQ

3.14e-048482MM15032
PathwayREACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION

GNA11 GNAQ

3.14e-048482M27356
PathwayKEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY

ACVR2A ACVR2B

3.14e-048482M47849
PathwayKEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY

ACVR2A ACVR2B

3.14e-048482M47846
PathwayKEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY

TGFBR1 ACVR2B

3.14e-048482M47847
PathwayREACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION

GNA11 GNAQ

3.14e-048482MM15100
PathwayWP_HIPPO_SIGNALING_REGULATION

GNA11 GNAI3 GNAL GNAQ

3.38e-0498484M39830
PathwayKEGG_MEDICUS_REFERENCE_LPA_GNAQ_11_RHOA_SIGNALING_PATHWAY

GNA11 GNAQ

4.03e-049482M47732
PathwayPID_THROMBIN_PAR1_PATHWAY

GNA11 GNAI3 GNAQ

4.16e-0443483M238
PathwayREACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION

GNA11 GNAQ

5.02e-0410482M1825
PathwayREACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION

GNA11 GNAQ

6.12e-0411482M27317
PathwayREACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION

GNA11 GNAQ

6.12e-0411482MM15035
PathwayKEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY

GNA11 GNAQ

6.12e-0411482M47637
PathwayKEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY

GNA11 GNAQ

7.33e-0412482M47649
PathwayREACTOME_REGULATION_OF_SIGNALING_BY_NODAL

ACVR2A ACVR2B

7.33e-0412482M26952
PathwayREACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY

GNAI3 GNAL

1.01e-0314482MM14669
PathwayREACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY

GNAI3 GNAL

1.01e-0314482M750
PathwayPID_THROMBIN_PAR4_PATHWAY

GNA11 GNAQ

1.16e-0315482M138
PathwayREACTOME_SIGNALING_BY_ACTIVIN

ACVR2A ACVR2B

1.16e-0315482MM14593
PathwayBIOCARTA_RACC_PATHWAY

KCNQ5 KCNQ2

1.16e-0315482M22002
PathwayPID_LYSOPHOSPHOLIPID_PATHWAY

GNA11 GNAI3 GNAQ

1.40e-0365483M15
PathwayREACTOME_SIGNALING_BY_ACTIVIN

ACVR2A ACVR2B

1.49e-0317482M26965
PathwayKEGG_LONG_TERM_DEPRESSION

GNA11 GNAI3 GNAQ

1.73e-0370483M8232
PathwayKEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY

ACVR2A ACVR2B

2.07e-0320482M47843
PathwayREACTOME_SIGNALING_BY_TGFBR3

TGFBR1 ACVR2A

2.29e-0321482MM17231
PathwayKEGG_MEDICUS_REFERENCE_GNRH_GNRHR_PLCB_PKC_SIGNALING_PATHWAY

GNA11 GNAQ

2.29e-0321482M47638
PathwayWP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA

GNA11 GNAQ

2.51e-0322482M39795
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

NCOA1 SLC27A2

2.74e-0323482M1926
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

NCOA1 SLC27A2

2.74e-0323482MM14741
PathwayREACTOME_SIGNALING_BY_NODAL

ACVR2A ACVR2B

2.74e-0323482M511
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

GNA11 GNAI3 GNAL GNAQ GNAT2

2.91e-03289485MM15057
PathwayREACTOME_G_PROTEIN_ACTIVATION

GNA11 GNAQ

2.99e-0324482M13115
PathwayREACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR

GNA11 GNAQ

2.99e-0324482M18308
PathwayREACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR

GNA11 GNAQ

2.99e-0324482MM15088
PathwayREACTOME_G_PROTEIN_ACTIVATION

GNA11 GNAQ

2.99e-0324482MM14794
PathwayWP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY

GNA11 GNAI3 GNAQ

3.01e-0385483M48315
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

GNA11 CACNA1I GNAL GNAQ

3.10e-03178484M2890
PathwayKEGG_TGF_BETA_SIGNALING_PATHWAY

TGFBR1 ACVR2A ACVR2B

3.11e-0386483M2642
PathwayREACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1

GNA11 GNAQ

3.24e-0325482MM15056
PathwayREACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1

GNA11 GNAQ

3.24e-0325482M811
PathwayWP_GROWTH_FACTORS_AND_HORMONES_IN_BETA_CELL_PROLIFERATION

TGFBR1 RASSF1

3.50e-0326482M48092
PathwayKEGG_GAP_JUNCTION

GNA11 GNAI3 GNAQ

3.54e-0390483M4013
Pubmed

G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development.

GNA11 GNAI3 GNAL GNAQ GNAT2

1.13e-09285958858601
Pubmed

Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors.

GNA11 CACNA1I GNAQ

4.64e-09359317535809
Pubmed

Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).

GNA11 GNAI3 GNAQ GNAT2

1.01e-081559411118617
Pubmed

Evolution of the mammalian G protein alpha subunit multigene family.

GNA11 GNAI3 GNAL GNAQ GNAT2

2.13e-08495951302014
Pubmed

Local versus systemic control of bone and skeletal muscle mass by components of the transforming growth factor-β signaling pathway.

TGFBR1 ACVR2A ACVR2B

4.63e-08559334385332
Pubmed

D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum.

GNA11 GNAL GNAQ

9.24e-08659317194762
Pubmed

Activation of signalling by the activin receptor complex.

TGFBR1 ACVR2A ACVR2B

9.24e-0865938622651
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

SCO2 CELSR3 SND1 GNAI3 GNAL GNAT2 NSUN2

1.32e-0723159736597993
Pubmed

Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.

TGFBR1 ACVR2A ACVR2B

1.62e-0775939748228
Pubmed

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.

TGFBR1 ACVR2A ACVR2B

2.58e-0785938242742
Pubmed

Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator.

GNA11 GNAQ GNAT2

3.87e-0795931322796
Pubmed

Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.

TGFBR1 ACVR2A ACVR2B

5.52e-071059315611116
Pubmed

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.

GNA11 GNAI3 GNAQ

5.52e-07105938552586
Pubmed

Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis.

GNA11 GNAI3 GNAQ

7.58e-071159332332099
Pubmed

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily.

TGFBR1 ACVR2A ACVR2B

7.58e-07115939872992
Pubmed

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.

GNA11 GNAI3 GNAL

1.01e-06125932508088
Pubmed

Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion.

TGFBR1 ACVR2A ACVR2B

1.01e-061259316806156
Pubmed

Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.

TGFBR1 ACVR2A ACVR2B

1.01e-061259323342175
Pubmed

Mechanism of GTP hydrolysis by G-protein alpha subunits.

GNA11 GNAL GNAQ

2.08e-06155937937899
Pubmed

GNAQ and GNA11 mutations occur in 9.5% of mucosal melanoma and are associated with poor prognosis.

GNA11 GNAQ

2.83e-06259227498141
Pubmed

The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan.

GNA11 GNAQ

2.83e-06259228248732
Pubmed

Uveal Melanoma: GNAQ and GNA11 Mutations in a Greek Population.

GNA11 GNAQ

2.83e-06259228982892
Pubmed

Mutations in GNA11 in uveal melanoma.

GNA11 GNAQ

2.83e-06259221083380
Pubmed

Activation of Gq/11 in the mouse corpus luteum is required for parturition.

GNA11 GNAQ

2.83e-06259225495873
Pubmed

GNAQ and GNA11 mutations in uveal melanoma.

GNA11 GNAQ

2.83e-06259225304237
Pubmed

mRNAs for activin receptors II and IIB are expressed in mouse oocytes and in the epiblast of pregastrula and gastrula stage mouse embryos.

ACVR2A ACVR2B

2.83e-0625927748787
Pubmed

Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.

GNA11 GNAQ

2.83e-06259228301547
Pubmed

Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation.

GNA11 GNAQ

2.83e-06259216847339
Pubmed

Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.

GNA11 GNAQ

2.83e-06259229570931
Pubmed

Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice.

GNA11 GNAQ

2.83e-06259210818132
Pubmed

Overexpression of human fatty acid transport protein 2/very long chain acyl-CoA synthetase 1 (FATP2/Acsvl1) reveals distinct patterns of trafficking of exogenous fatty acids.

SLC27A1 SLC27A2

2.83e-06259224113382
Pubmed

Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.

GNA11 GNAQ

2.83e-06259226272756
Pubmed

NK2 receptor-mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent Ca2+ channels and the RhoA-Rho kinase pathway.

GNA11 GNAQ

2.83e-06259231461351
Pubmed

Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma.

GNA11 GNAQ

2.83e-06259223634288
Pubmed

Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism.

GNA11 GNAQ

2.83e-06259226368812
Pubmed

Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current.

GNA11 GNAQ

2.83e-06259217482476
Pubmed

The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin.

LTF SLC40A1

2.83e-06259229453656
Pubmed

KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.

KCNQ5 KCNQ2

2.83e-06259235320039
Pubmed

Molecular genetic testing of uveal melanoma from routinely processed and stained cytology specimens.

GNA11 GNAQ

2.83e-06259221945171
Pubmed

Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.

GNA11 GNAQ

2.83e-06259224141786
Pubmed

Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.

GNA11 GNAQ

2.83e-0625929175863
Pubmed

The ethnic profile of patients with birthmarks reveals interaction of germline and postzygotic genetics.

GNA11 GNAQ

2.83e-06259228083870
Pubmed

Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.

GNA11 GNAQ

2.83e-06259237102682
Pubmed

Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation.

GNA11 GNAQ

2.83e-06259226843449
Pubmed

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.

GNA11 GNAQ

2.83e-06259230890659
Pubmed

Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.

GNA11 GNAQ

2.83e-0625927492305
Pubmed

Reduced trabecular bone mass and strength in mice overexpressing Gα11 protein in cells of the osteoblast lineage.

GNA11 GNAQ

2.83e-06259224308950
Pubmed

Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes.

GNA11 GNAQ

2.83e-06259222562663
Pubmed

Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons.

GNA11 GNAQ

2.83e-06259211826096
Pubmed

Blue nevi and variants: an update.

GNA11 GNAQ

2.83e-06259221366456
Pubmed

Formation and activation by phosphorylation of activin receptor complexes.

ACVR2A ACVR2B

2.83e-0625928721982
Pubmed

In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations.

GNA11 GNAQ

2.83e-06259235580369
Pubmed

Gonadotropin and gonadal steroid release in response to a gonadotropin-releasing hormone agonist in Gqalpha and G11alpha knockout mice.

GNA11 GNAQ

2.83e-0625929607776
Pubmed

Reverse Phenotyping in Patients with Skin Capillary Malformations and Mosaic GNAQ or GNA11 Mutations Defines a Clinical Spectrum with Genotype-Phenotype Correlation.

GNA11 GNAQ

2.83e-06259231726051
Pubmed

Papillary Hemangioma Harbors Somatic GNA11 and GNAQ Mutations.

GNA11 GNAQ

2.83e-06259237750536
Pubmed

G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region.

GNA11 GNAQ

2.83e-06259211438569
Pubmed

GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification.

GNA11 GNAQ

2.83e-06259237802294
Pubmed

Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.

GNA11 GNAQ

2.83e-06259226778290
Pubmed

Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.

GNA11 GNAQ

2.83e-06259226628681
Pubmed

Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass.

ACVR2A ACVR2B

2.83e-06259228659341
Pubmed

Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis.

GNA11 GNAQ

2.83e-06259230936140
Pubmed

The time-course of agonist-induced solubilization of trimeric G(q)alpha/G(11)alpha proteins resolved by two-dimensional electrophoresis.

GNA11 GNAQ

2.83e-06259217552882
Pubmed

Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11.

GNA11 GNAQ

2.83e-06259223778528
Pubmed

High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.

GNA11 GNAQ

2.83e-06259222977135
Pubmed

An experimental strategy to probe Gq contribution to signal transduction in living cells.

GNA11 GNAQ

2.83e-06259233639168
Pubmed

GNAQ and GNA11 mutant nonuveal melanoma: a subtype distinct from both cutaneous and uveal melanoma.

GNA11 GNAQ

2.83e-06259232064597
Pubmed

Mutational analysis of GNAQ and GNA11 to aid therapy management of a choroidal melanoma metastatic to the contralateral orbit.

GNA11 GNAQ

2.83e-06259223572068
Pubmed

Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations.

GNA11 GNAQ

2.83e-06259231173078
Pubmed

Low mutational burden of eight genes involved in the MAPK/ERK, PI3K/AKT, and GNAQ/11 pathways in female genital tract primary melanomas.

GNA11 GNAQ

2.83e-06259225695059
Pubmed

Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas.

GNA11 GNAQ

2.83e-06259229209985
Pubmed

Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1.

GNA11 GNAQ

2.83e-06259212351712
Pubmed

Cardiac remodeling in Gαq and Gα11 knockout mice.

GNA11 GNAQ

2.83e-06259226476043
Pubmed

Expression of activin receptor II and IIB mRNA isoforms in mouse reproductive organs and oocytes.

ACVR2A ACVR2B

2.83e-0625928049070
Pubmed

Structure of the mouse activin receptor type II gene.

ACVR2A ACVR2B

2.83e-0625921318045
Pubmed

Characterization of type II activin receptors. Binding, processing, and phosphorylation.

ACVR2A ACVR2B

2.83e-0625928395525
Pubmed

Early-onset hypertension associated with extensive cutaneous capillary malformations harboring postzygotic variants in GNAQ and GNA11.

GNA11 GNAQ

2.83e-06259236440997
Pubmed

Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice.

GNA11 GNAQ

2.83e-06259215713647
Pubmed

Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior.

GNA11 GNAQ

2.83e-06259215175381
Pubmed

GNAQ and GNA11 mutations in melanocytomas of the central nervous system.

GNA11 GNAQ

2.83e-06259222307269
Pubmed

Oncogenic GNAQ and GNA11 mutations in uveal melanoma in Chinese.

GNA11 GNAQ

2.83e-06259225280020
Pubmed

Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.

GNA11 GNAQ

8.48e-06359228700778
Pubmed

Dissecting Gq/11-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1.

GNA11 GNAQ

8.48e-06359233003441
Pubmed

P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.

GNA11 GNAQ

8.48e-06359226168216
Pubmed

The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.

GNA11 GNAQ

8.48e-06359210446129
Pubmed

Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.

GNA11 GNAQ

8.48e-0635928836152
Pubmed

Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.

GNA11 GNAQ

8.48e-06359233166186
Pubmed

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes.

GNA11 GNAQ

8.48e-06359211689889
Pubmed

Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation.

ACVR2A ACVR2B

8.48e-06359214738881
Pubmed

Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes.

GNA11 GNAQ

8.48e-06359220372981
Pubmed

Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension.

GNA11 GNAQ

8.48e-06359225595485
Pubmed

The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects.

GNA11 GNAQ

8.48e-06359232576659
Pubmed

Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development.

GNA11 GNAQ

8.48e-06359217694176
Pubmed

Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation.

KCNQ5 KCNQ2

8.48e-06359212890507
Pubmed

Identification of HRAS mutations and absence of GNAQ or GNA11 mutations in deep penetrating nevi.

GNA11 GNAQ

8.48e-06359223599145
Pubmed

Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice.

GNA11 GNAQ

8.48e-06359215340067
Pubmed

Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence.

GNA11 GNAQ

8.48e-06359215872115
Pubmed

GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system.

GNA11 GNAQ

8.48e-06359222758774
Pubmed

Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.

GNA11 GNAQ

8.48e-06359221464134
Pubmed

G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.

GNA11 GNAQ

8.48e-0635922123549
Pubmed

Regulation of muscle growth by multiple ligands signaling through activin type II receptors.

ACVR2A ACVR2B

8.48e-06359216330774
InteractionGNG4 interactions

DHRS3 GNA11 GNAI3 GNAQ

8.00e-0725594int:GNG4
InteractionRGS16 interactions

GNAI3 GNAQ ST14

1.57e-0517593int:RGS16
InteractionMETTL14 interactions

SCO2 CELSR3 SND1 LSM4 GNAI3 GNAL LTF GNAT2 NSUN2

3.28e-05558599int:METTL14
InteractionGNAO1 interactions

GNA11 GNAI3 GNAQ GNAT2 SYNGAP1

4.21e-05132595int:GNAO1
InteractionGNG3 interactions

GNA11 GNAQ GNAT2

4.62e-0524593int:GNG3
InteractionZDHHC23 interactions

NCOA1 GNA11 GNAQ GLIS1

6.54e-0574594int:ZDHHC23
GeneFamilyType 2 receptor serine/threonine kinases

ACVR2A ACVR2B

5.00e-055412346
GeneFamilyAcyl-CoA synthetase family

SLC27A1 SLC27A2

1.58e-032641240
GeneFamilyPotassium voltage-gated channels

KCNQ5 KCNQ2

3.71e-0340412274
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

PAPPA2 CSMD3

7.40e-03574121179
CoexpressionLI_PBMC_MENACTRA_AGE_18_45YO_CORRELATED_WITH_ANTI_POLYSACCHARIDE_ANTIBODY_3DY_NEGATIVE

WDFY4 SLC40A1 SLC27A2

1.02e-0519593M41038
CoexpressionGSE7568_IL4_VS_IL4_AND_DEXAMETHASONE_TREATED_MACROPHAGE_DN

PAPPA2 NEURL3 ASH1L GNA11 ACVR2A

2.31e-05151595M369
ToppCellNS-critical-d_0-4-Epithelial-FOXN4+|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LMF1 BOK BEND3 LIPT2 GNA11 OCRL

1.09e-07172596a00bb44d33658cb3a98accd6b60f3ce964c425b4
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NEURL3 BEND3 LTF PLEKHO1 PRODH

3.55e-06175595dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TGFBR1 CD5L DHRS3 WDFY4 ARAP1

5.72e-06193595697518bab1338dc441b2d93b410d957e692f20e6
ToppCellproximal-Epithelial-Differentiating_Basal-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NEURL3 DHRS3 LMTK3 SLC27A2 TRIM7

6.64e-06199595c607346f60e5997e757e5a31cab412ab3734377b
ToppCellproximal-3-Epithelial-Differentiating_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NEURL3 DHRS3 LMTK3 SLC27A2 TRIM7

6.64e-0619959512e07084fc2d5d4c418df564ccc0e132b056e549
ToppCellproximal-Epithelial-Differentiating_Basal|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NEURL3 DHRS3 LMTK3 SLC27A2 TRIM7

6.64e-0619959596a89a2578fad9a99c52d2cf9e26e06516a96568
ToppCellPND07-Immune-Immune_Myeloid-DC-cDC2|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NEURL3 KCNQ2 WDFY4 PLEKHO1

4.56e-0514959432e0be7da42d26956683b21a1e7ae6915e4c16fb
ToppCellfacs-Marrow-B-cells-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNQ2 LTF LY75 SLC40A1

5.59e-051575940673c7161c25feceee8f1e5fd237171576c42c6b
ToppCellfacs-Marrow-B-cells-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNQ2 LTF LY75 SLC40A1

5.59e-05157594d307d0b48af35e0e1af41ecd3ebf91be8fd29dc0
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD5L TRIM21 SLC40A1 ARAP1

5.73e-05158594d3446fc98eff09c3626b47a2c90d07cd985378b5
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD5L TRIM21 SLC40A1 ARAP1

5.73e-05158594df614450e10629dc9115d7365397663e82f9e48f
ToppCelldroplet-Heart-nan-24m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZC3H12D LY75 WDFY4 TRIM7

6.17e-051615947e60001637ef0f6fc67ef8a36ab80ebb25b0b0ab
ToppCellfacs|World / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHRS3 GNA11 GNAQ TRIM7

7.79e-051715945bcb96ed7fc15548f2dc9cf47482f890640cb39c
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD5L PRXL2B NCOA1 SLC40A1

7.79e-05171594a474aaed3ca4cacb0ab565c35f25d92a10f531b7
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHRS3 BEND3 ACVR2A PRODH

7.79e-05171594d1e87478d8c0329e662849823f5c7604f20e1b1a
ToppCellfacs|World / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DHRS3 GNA11 GNAQ TRIM7

7.79e-05171594bb71e816dde44fda6af0ad98d979be9f8740fda6
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1I KLHL33 WDFY4 TRIM7

8.33e-0517459428ec25767bbd4fd898738f9f4d2b585dc91b5adf
ToppCellnormal_Lung-T/NK_cells-Exhausted_Tfh|T/NK_cells / Location, Cell class and cell subclass

KCNQ5 GNA11 PLEKHO1 SLC27A2

8.33e-05174594e324320b52c904496e26fcecfa179b3431729ec0
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CD5L OCRL ACVR2A TRIM7

9.10e-051785949d575902d3dbe33437c9d4200df093a741269803
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNQ5 ZC3H12D CACNA1I TRIM7

9.10e-05178594ba5a477257877f4a15a91c1762ffcc6f2e9f7357
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNQ5 ZC3H12D CACNA1I TRIM7

9.10e-051785945634c1fbc817758092af4feafff94d107412d89b
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|368C / Donor, Lineage, Cell class and subclass (all cells)

CD5L OCRL WDFY4 TRIM7

9.10e-05178594536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CELSR3 PRXL2B KCNQ2 STK35

9.50e-05180594c72f15763ba707189e29c85db533557f01c7fdb1
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Lymphocytic-B_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEURL3 ZC3H12D WDFY4 TRIM7

1.01e-0418359420f7b6ec2462032eda957a893ca76d5a5a01333d
ToppCellfacs-Lung-3m-Hematologic-lymphocytic-B_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZC3H12D CACNA1I WDFY4 TRIM7

1.10e-0418759457f9c9162694c184a8fd6634ee0fad511ca71c9e
ToppCellfacs-Lung-3m-Hematologic-lymphocytic-B_cell-B_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZC3H12D CACNA1I WDFY4 TRIM7

1.10e-041875946ce6d3678026101c4397320430433c9f05740883
ToppCelldistal-Hematologic-IGSF21+_Dendritic-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZC3H12D CACNA1I PLEKHO1 SLC40A1

1.24e-0419359448ce11778252ae2ef902b30816061b59a3c81695
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TGFBR1 CD5L DHRS3 PLEKHO1

1.24e-04193594b52d5661edff83ac4c5fe2bf89d6672016bb827b
ToppCellControl-Myeloid-MoAM4|Myeloid / Condition, Lineage and Cell class

TGFBR1 PLEKHO1 SLC40A1 ST14

1.27e-041945947ab808dd1876b0eec2831caa16d04fd859b1dc50
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GNAQ WDFY4 PLEKHO1 ST14

1.27e-04194594b16ed97eb6b7b7a220e943474c0d85c141b6e3a5
ToppCelldistal-1-Hematologic-IGSF21+_Dendritic|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZC3H12D CACNA1I PLEKHO1 SLC40A1

1.27e-04194594f30c866e5f41ee79bdc6b6e08af962d62b199835
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GNAQ WDFY4 PLEKHO1 ST14

1.27e-041945942210f0755882d8f04edb4c109fb17c3f9149f6f7
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DHRS3 ZC3H12D CACNA1I GNAQ

1.27e-04194594a44be2f021cfdd0fcdc698c3f04d66db7a1aa6c2
ToppCellControl-Myeloid-MoAM4|Control / Condition, Lineage and Cell class

TGFBR1 PLEKHO1 SLC40A1 ST14

1.29e-04195594211a736acbe875bd3c1942c62aaacc9b170ece6d
ToppCellTracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ZC3H12D LSM4 WDFY4 PLEKHO1

1.32e-04196594b71d711be5609115b00a57700885aca608920896
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

BOK DHRS3 RASSF1 GNAL

1.32e-0419659477da6b1bcab45d376eb0368f540e0ed24ce98b42
ToppCellCOVID-19_Severe-Lymphoid_T/NK-NK|COVID-19_Severe / Disease group, lineage and cell class

BOK DHRS3 RASSF1 GNAL

1.32e-04196594cc1daf12de5765ba4f7002396352404b41df2012
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

BOK DHRS3 RASSF1 GNAL

1.32e-04196594d3bd8fab010e76024d7e06aba0ea5df3394f411f
ToppCellPBMC-Control-cDC_3|Control / Compartment, Disease Groups and Clusters

DHRS3 LY75 WDFY4 ST14

1.32e-0419659409d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

BOK DHRS3 RASSF1 GNAL

1.34e-041975949993fdea353abeafc009ac87439ad25cedf8f1f6
ToppCellhematopoetic_progenitors-CD34+_MEP_1|hematopoetic_progenitors / Lineage and Cell class

DHRS3 GNAQ SLC40A1 SLC27A2

1.34e-041975946172a1b98ff840d9174b1ab20ba0c202a7ef87af
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

BOK DHRS3 RASSF1 GNAL

1.34e-04197594a8b41fffa4e86f2766423392951ff320e821a19a
ToppCellCOVID-19_Severe-CD4+_Tcm|COVID-19_Severe / Disease condition and Cell class

ZC3H12D GNAQ ACVR2A SLC40A1

1.34e-04197594f69083480ccf6f1854e5031d1a3e181bdcc8aea0
ToppCellsevere_COVID-19-NK|severe_COVID-19 / disease group, cell group and cell class (v2)

BOK DHRS3 RASSF1 GNAL

1.37e-041985947f51e37516f717e424190e6584f1c74d357e2da4
ToppCellproximal-3-Epithelial-Goblet|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LMTK3 ST14 SLC27A2 TRIM7

1.37e-041985943477202c4f702d8f75231b13d4b5216f56d981d7
ToppCellsevere_COVID-19-NK|World / disease group, cell group and cell class (v2)

BOK DHRS3 RASSF1 GNAL

1.37e-0419859436b1370ef68c4bbe0268933a6ef5e6022d992bdf
ToppCellproximal-Epithelial-Goblet-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LMTK3 ST14 SLC27A2 TRIM7

1.37e-04198594da7b40eb00bb5e454e1cfcd1219dc0d84712592a
ToppCellproximal-Epithelial-Goblet|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LMTK3 ST14 SLC27A2 TRIM7

1.37e-04198594e7e1c430486a81280abc4a7e7f5bc3713dd20737
ToppCellwk_15-18-Hematologic-Myeloid-APOE+_Mac1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CD5L KATNB1 TRIM21 SLC40A1

1.37e-0419859488182ad964db88cf85b3e3a64929d07d59a923c2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD5L WDFY4 PLEKHO1 SLC40A1

1.40e-04199594ca0f6526ba0dcf8789dd3b583291519626427f2f
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_basal-Dividing_Basal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NEURL3 LMTK3 PRODH SLC27A2

1.40e-04199594fe22833e69928a1478df265e1c356c463611dedd
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-NK|COVID-19_Severe / Disease, condition lineage and cell class

BOK DHRS3 RASSF1 GNAL

1.42e-042005942580b7b83ba707718fe23ffca986e7a55ea85bce
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-mo-Mac|Myeloid_cells / Location, Cell class and cell subclass

TGFBR1 DHRS3 SLC40A1 ST14

1.42e-04200594195862a319794e57f0506757ae45ab70200bc5b4
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_basal-Suprabasal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NEURL3 LTF LMTK3 TRIM7

1.42e-04200594d536180a308abc5703d5c8bb33dfe57dc4cc6577
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DHRS3 WDFY4 ST14 ARAP1

1.42e-0420059480e0483d5ab0c6213aae0ec62619f57e6ec0e4c2
ToppCellPBMC-Severe-cDC_1|Severe / Compartment, Disease Groups and Clusters

SCO2 BEND3 WDFY4

1.70e-04815936d1e524f000b71c935359afc801a1d31f218fec8
ToppCellFrontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CD5L NEURL3 WDFY4

2.56e-0493593d102a0a015a2866e3fe549ac8796b9a0d5923d7e
ToppCellFrontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CD5L NEURL3 WDFY4

2.56e-04935930967a93dcc72d2d8f12d56de186ec1af55c36001
ToppCellFrontal_cortex-Hematopoietic-MACROPHAGE|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CD5L NEURL3 WDFY4

2.56e-04935931a112bd4e5e63826efad0338ce99d7a7ad9c72b9
ToppCellFrontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CD5L NEURL3 WDFY4

2.56e-04935939c566fc2a8c7630bea28e8e46df55454aa409bc1
ToppCellFrontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CD5L NEURL3 WDFY4

2.56e-0493593613c827a643a7b6d70ef932cfa1762e90bc5a338
Drugcarisbamate

KCNQ5 KCNQ2 LTF

9.04e-0616593CID006918474
Drugmagnesium fluoride

GNAI3 GNAL GNAQ GNAT2

1.08e-0553594CID000024546
DrugGly-His-Lys acetate salt; Up 200; 1uM; PC3; HT_HG-U133A

PRPF4 RASSF1 KATNB1 LSM4 OCRL SLC27A2

1.16e-051965966570_UP
Drughp 5B

GNAL GNAQ LTF

1.56e-0519593CID000123651
DrugC24:0

AGL SLC27A1 ST14 SLC27A2

1.90e-0561594CID000011197
DrugTAAD

TGFBR1 ACVR2A ACVR2B

2.13e-0521593CID000133445
Drugap1-6

TGFBR1 ACVR2A ACVR2B

2.82e-0523593CID003030073
DiseasePhakomatosis cesioflammea

GNA11 GNAQ

3.93e-062592C3838883
DiseaseCongenital hemangioma

GNA11 GNAQ

3.93e-062592C0235753
DiseasePort-wine stain with oculocutaneous melanosis

GNA11 GNAQ

3.93e-062592C1274879
DiseaseMalignant melanoma of iris

GNA11 GNAQ

3.92e-055592C0346373
DiseaseMalignant melanoma of choroid

GNA11 GNAQ

3.92e-055592C0346388
DiseaseUveal melanoma

GNA11 GNAQ

1.09e-048592C0220633
DiseaseMcCune Albright syndrome (implicated_via_orthology)

GNAI3 GNAT2

1.09e-048592DOID:1858 (implicated_via_orthology)
DiseaseMarfan syndrome (implicated_via_orthology)

ACVR2A ACVR2B

1.75e-0410592DOID:14323 (implicated_via_orthology)
Diseaselong QT syndrome (implicated_via_orthology)

KCNQ5 KCNQ2

1.75e-0410592DOID:2843 (implicated_via_orthology)
DiseaseAutistic Disorder

SND1 CSMD3 WDFY4 SLC40A1 SYNGAP1

1.77e-04261595C0004352
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

ACVR2A ACVR2B

3.02e-0413592DOID:0050787 (implicated_via_orthology)
Diseasedevelopmental and epileptic encephalopathy (implicated_via_orthology)

KCNQ5 KCNQ2

3.02e-0413592DOID:0112202 (implicated_via_orthology)
Diseaseschizophrenia (implicated_via_orthology)

CSMD3 PRODH SYNGAP1

3.47e-0468593DOID:5419 (implicated_via_orthology)
Diseaserenal cell carcinoma (is_implicated_in)

RASSF1 LTF XRCC1

3.62e-0469593DOID:4450 (is_implicated_in)
DiseaseMyopia

SCO2 KCNQ5

4.06e-0415592C0027092
Diseasepeak expiratory flow

PAPPA2 BOK KCNQ5 ZC3H12D NCOA1 KCNQ2

4.74e-04498596EFO_0009718
Diseaseurinary bladder cancer (is_implicated_in)

TGFBR1 RASSF1 XRCC1

4.81e-0476593DOID:11054 (is_implicated_in)
DiseaseNeurodevelopmental Disorders

ASH1L KCNQ2 SYNGAP1

8.67e-0493593C1535926
Diseasetransitional cell carcinoma (is_implicated_in)

RASSF1 XRCC1

8.85e-0422592DOID:2671 (is_implicated_in)
DiseaseLynch syndrome (is_implicated_in)

TGFBR1 ACVR2A

1.05e-0324592DOID:3883 (is_implicated_in)
DiseaseHypertrophic obstructive cardiomyopathy

SCO2 RASSF1

1.14e-0325592C4551472
Diseaseproline measurement

KCNQ5 PRODH

1.24e-0326592EFO_0009773
DiseaseMicronuclei, Chromosome-Defective

RASSF1 XRCC1

1.24e-0326592C1449861
DiseaseMicronuclei, Genotoxicant-Induced

RASSF1 XRCC1

1.24e-0326592C1449862
Diseaselysophosphatidylethanolamine 20:4 measurement

CACNA1I FBXO33

1.54e-0329592EFO_0010370
DiseaseChild Development Disorders, Specific

KCNQ2 WDFY4

1.54e-0329592C0085997
DiseaseChild Development Deviations

KCNQ2 WDFY4

1.54e-0329592C0085996
Diseasecervical cancer (is_implicated_in)

RASSF1 XRCC1

1.65e-0330592DOID:4362 (is_implicated_in)
DiseaseDevelopmental Disabilities

KCNQ2 WDFY4

1.65e-0330592C0008073
Diseaseheart conduction disease (implicated_via_orthology)

KCNQ5 KCNQ2

1.88e-0332592DOID:10273 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
VIAGGICIFWKRQRE

BTNL10

266

A8MVZ5
CLERFRAEEKGWGIR

ASH1L

2146

Q9NR48
VVRWACDRGFRLVGK

CSMD3

2591

Q7Z407
EVKARGRFGCVWKAQ

ACVR2A

196

P27037
GWSLRAAKVVCRQLG

CD5L

166

O43866
RRRGGWTDVLKCVVS

BOK

166

Q9UMX3
FIWGVVRKGLQCARL

RASSF1

71

Q9NS23
VGGQRSERRKWIHCF

GNAQ

206

P50148
VLCGWRGKASIRTFV

NSUN2

676

Q08J23
WTLEFVGKLDERCRR

BEND3

631

Q5T5X7
RAFRCGVGLVRTVEW

KLHL33

236

A6NCF5
VIKRLWRDGGVQACF

GNAI3

126

P08754
WQGRLRFARKPFCVI

KCNQ5

191

Q9NR82
LWDIRRKGCVFRYRG

KATNB1

131

Q9BVA0
NLECLWEKARRGAGR

LMTK3

476

Q96Q04
KCGWFVRELRVEFAA

FBXO33

131

Q7Z6M2
GWRGRLKFARKPFCV

KCNQ2

156

O43526
VLWDLGRDFRCTVGK

KBTBD2

571

Q8IY47
GRILVVRWKAEDCRL

LAGE3

101

Q14657
DCAAVKVFHRPWRRG

LY75

751

O60449
VGGQRDERRKWIQCF

GNAL

211

P38405
EGERCWLGAKVRRPR

PAPPA2

46

Q9BXP8
LCGDVWRETRAKLRG

CACNA1I

621

Q9P0X4
VGGQRSERRKWIHCF

GNA11

206

P29992
REVICTSRDGDKFWR

LSM4

41

Q9Y4Z0
LAGRVVAGRQACRWV

GLIS1

186

Q8NBF1
RKRVGTARCCGELWA

CELSR3

196

Q9NYQ7
GRARCKADFRGQWVL

SCO2

111

O43819
KLIDFGCARRLAWAG

MAP3K19

1201

Q56UN5
REFAERGARKIVLWG

DHRS3

56

O75911
WLDDRKICAIGVRCG

LIPT2

146

A6NK58
RKNEEAAWGPRVCRA

NRAC

21

Q8N912
VAGLRRFGCVVCRWI

PRXL2B

36

Q8TBF2
EVAARRARVVWCAVG

LTF

356

P02788
DAFGRVWDLRTGRCI

PRPF4

386

O43172
LRGDVWRQFVKRFGD

SLC27A2

341

O14975
RAAGRTGWEDLVRKC

NCOA1

281

Q15788
VIRRLWKDGGVQACF

GNAT2

126

P19087
GSCARVAAWGGKLRR

MICU2

6

Q8IYU8
DVELARREGWCFGAK

PRODH

426

O43272
RREGWCFGAKLVRGA

PRODH

431

O43272
RRGEFCIAKFVDGEW

SND1

731

Q7KZF4
GTVAFTWLRRKCGLV

SLC40A1

356

Q9NP59
GWVRKFCGKGIFREI

PLEKHO1

26

Q53GL0
GCKIRVQGDWIRERR

OCRL

81

Q01968
LVFWEIARRCSIGGI

TGFBR1

406

P36897
REEFSRRWCVLGDGV

ARAP1

766

Q96P48
QLLEIKARGRFGCVW

ACVR2B

191

Q13705
IRWRSCKGERNFAER

C12orf76

61

Q8N812
GKRAARKWRCAGQVT

STK35

86

Q8TDR2
GWRGAACDQRVLIVR

TYRP1

116

P17643
KDGWAFGVARESVRR

TRIM7

406

Q9C029
KEVFASWRLRCAERG

SYNGAP1

566

Q96PV0
VGSGGWRFLRIVCKT

SLC27A1

36

Q6PCB7
TGRCIRKELRCDGWA

ST14

461

Q9Y5Y6
TKLLVGDERGRIFCW

WDFY4

3166

Q6ZS81
KEAWDLGVCRDSVRR

TRIM21

351

P19474
DLVRFWVDRRGCLFA

NEURL3

121

Q96EH8
WVDRRGCLFAKVNAG

NEURL3

126

Q96EH8
CRGIKLAVDWFRDRG

ZC3H12D

111

A2A288
LGGRIVRKEWVLDCH

XRCC1

376

P18887
FRCWGRDTFIALRGI

AGL

1096

P35573
AGLIKIRGDRCWRDL

LMF1

221

Q96S06