Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransketolase activity

TKTL1 TKTL2

3.03e-053642GO:0004802
GeneOntologyMolecularFunctiontransketolase or transaldolase activity

TKTL1 TKTL2

1.01e-045642GO:0016744
GeneOntologyMolecularFunctionthiamine pyrophosphate binding

TKTL1 TKTL2

2.80e-048642GO:0030976
GeneOntologyCellularComponentextracellular matrix

RELN ADAMTSL1 PTPRZ1 AGT USH2A SSPOP ANGPTL7 MUC5AC CCN3

1.65e-04656649GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

RELN ADAMTSL1 PTPRZ1 AGT USH2A SSPOP ANGPTL7 MUC5AC CCN3

1.69e-04658649GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

RELN ADAMTSL1 PTPRZ1 AGT USH2A SSPOP ANGPTL7 CCN3

2.06e-04530648GO:0062023
GeneOntologyCellularComponentcell body

RELN PTPRZ1 LRRK2 ROBO1 ASTN1 WDFY3 GNB3 USH2A NAXE CCN3

4.90e-049296410GO:0044297
DomainCTCK_1

SSPOP MUC5AC CCN3

2.61e-0518613PS01185
DomainFN3

UMODL1 PTPRZ1 ROBO1 ASTN1 MERTK USH2A

3.08e-05185616SM00060
DomainTRANSKETOLASE_1

TKTL1 TKTL2

3.14e-053612PS00801
DomainTRANSKETOLASE_2

TKTL1 TKTL2

3.14e-053612PS00802
DomainTransketolase_N

TKTL1 TKTL2

3.14e-053612PF00456
DomainTransketolase_N

TKTL1 TKTL2

3.14e-053612IPR005474
DomainFN3

UMODL1 PTPRZ1 ROBO1 ASTN1 MERTK USH2A

4.63e-05199616PS50853
DomainFN3_dom

UMODL1 PTPRZ1 ROBO1 ASTN1 MERTK USH2A

6.08e-05209616IPR003961
DomainCys_knot_C

SSPOP MUC5AC CCN3

7.24e-0525613IPR006207
DomainCTCK_2

SSPOP MUC5AC CCN3

7.24e-0525613PS01225
DomainTransketo_C/PFOR_II

TKTL1 TKTL2

1.04e-045612IPR009014
DomainTransketolase_C

TKTL1 TKTL2

1.04e-045612IPR033248
DomainTransketolase_fam

TKTL1 TKTL2

1.04e-045612IPR033247
DomainTransketolase_C

TKTL1 TKTL2

1.04e-045612PF02780
Domain-

TKTL1 TKTL2

1.04e-0456123.40.50.920
Domainfn3

UMODL1 PTPRZ1 ROBO1 MERTK USH2A

1.86e-04162615PF00041
DomainVWFC_1

SSPOP MUC5AC CCN3

2.19e-0436613PS01208
DomainWD40

CHAF1B EML5 LRRK2 WDFY3 GNB3 ARPC1B

2.37e-04268616SM00320
DomainWD40_repeat

CHAF1B EML5 LRRK2 WDFY3 GNB3 ARPC1B

2.56e-04272616IPR001680
DomainVWC

SSPOP MUC5AC CCN3

2.58e-0438613SM00214
DomainVWFC_2

SSPOP MUC5AC CCN3

2.58e-0438613PS50184
Domain-

ADAMTSL1 UMODL1 PTPRZ1 ROBO1 ASTN1 MERTK USH2A ALPK2 SECTM1

2.82e-046636192.60.40.10
DomainTransket_pyr

TKTL1 TKTL2

2.90e-048612SM00861
DomainTransket_pyr

TKTL1 TKTL2

2.90e-048612PF02779
DomainTransketolase-like_Pyr-bd

TKTL1 TKTL2

2.90e-048612IPR005475
DomainVWF_dom

SSPOP MUC5AC CCN3

3.48e-0442613IPR001007
DomainWD40_repeat_dom

CHAF1B EML5 LRRK2 WDFY3 GNB3 ARPC1B

4.10e-04297616IPR017986
DomainIg-like_fold

ADAMTSL1 UMODL1 PTPRZ1 ROBO1 ASTN1 MERTK USH2A ALPK2 SECTM1

4.47e-04706619IPR013783
DomainGprotein_B

CHAF1B GNB3

4.64e-0410612IPR001632
DomainPTBI

DOK6 IRS4

5.66e-0411612SM00310
DomainTIL

SSPOP MUC5AC

6.78e-0412612PF01826
DomainIRS_PTB

DOK6 IRS4

6.78e-0412612PS51064
DomainC8

SSPOP MUC5AC

6.78e-0412612PF08742
Domain-

CHAF1B EML5 LRRK2 WDFY3 GNB3 ARPC1B

7.47e-043336162.130.10.10
DomainWD40/YVTN_repeat-like_dom

CHAF1B EML5 LRRK2 WDFY3 GNB3 ARPC1B

7.71e-04335616IPR015943
DomainUnchr_dom_Cys-rich

SSPOP MUC5AC

8.00e-0413612IPR014853
DomainTHDP-binding

TKTL1 TKTL2

8.00e-0413612IPR029061
Domain-

TKTL1 TKTL2

8.00e-04136123.40.50.970
DomainC8

SSPOP MUC5AC

8.00e-0413612SM00832
DomainIRS_PTB

DOK6 IRS4

9.31e-0414612IPR002404
DomainTIL_dom

SSPOP MUC5AC

9.31e-0414612IPR002919
DomainIRS

DOK6 IRS4

9.31e-0414612PF02174
DomainEGF_3

RELN UMODL1 ASTN1 SSPOP ADGRL4

1.01e-03235615PS50026
DomainGlyco_hormone_CN

MUC5AC CCN3

1.07e-0315612IPR006208
DomainCys_knot

MUC5AC CCN3

1.07e-0315612PF00007
DomainTSP_1

ADAMTSL1 SSPOP CCN3

1.15e-0363613PF00090
DomainVWD

SSPOP MUC5AC

1.22e-0316612SM00216
DomainVWF_type-D

SSPOP MUC5AC

1.22e-0316612IPR001846
DomainVWFD

SSPOP MUC5AC

1.22e-0316612PS51233
DomainVWD

SSPOP MUC5AC

1.22e-0316612PF00094
DomainTSP1

ADAMTSL1 SSPOP CCN3

1.25e-0365613SM00209
DomainTSP1_rpt

ADAMTSL1 SSPOP CCN3

1.25e-0365613IPR000884
DomainTSP1

ADAMTSL1 SSPOP CCN3

1.25e-0365613PS50092
DomainEMI

UMODL1 SSPOP

1.38e-0317612PS51041
DomainEGF_1

RELN UMODL1 ASTN1 USH2A SSPOP

1.46e-03255615PS00022
DomainWD40

CHAF1B EML5 WDFY3 GNB3 ARPC1B

1.56e-03259615PF00400
DomainEGF_2

RELN UMODL1 ASTN1 SSPOP ADGRL4

1.72e-03265615PS01186
DomainVWC_out

SSPOP MUC5AC

1.73e-0319612SM00215
DomainWD40_repeat_CS

CHAF1B EML5 WDFY3 GNB3

2.03e-03164614IPR019775
DomainWD_REPEATS_1

CHAF1B EML5 WDFY3 GNB3 ARPC1B

2.12e-03278615PS00678
DomainWD_REPEATS_2

CHAF1B EML5 WDFY3 GNB3 ARPC1B

2.16e-03279615PS50082
DomainWD_REPEATS_REGION

CHAF1B EML5 WDFY3 GNB3 ARPC1B

2.16e-03279615PS50294
DomainCT

MUC5AC CCN3

2.32e-0322612SM00041
DomainIg_I-set

ADAMTSL1 ROBO1 MERTK ALPK2

3.45e-03190614IPR013098
DomainI-set

ADAMTSL1 ROBO1 MERTK ALPK2

3.45e-03190614PF07679
DomainVWC

MUC5AC CCN3

3.76e-0328612PF00093
DomainUBA

UBAP2 CBLB

4.30e-0330612SM00165
DomainGPCR_2_secretin-like_CS

ADCYAP1R1 ADGRL4

5.50e-0334612IPR017983
DomainUBA

UBAP2 CBLB

6.15e-0336612PF00627
Pubmed

The AGT and the GNB3 polymorphisms and insulin resistance in prehypertension.

AGT GNB3

3.44e-06265224722130
Pubmed

The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases.

TKTL1 TKTL2

3.44e-06265230646877
Pubmed

[Study on the association of predisposing genes with essential hypertension among Kazakhs ethnic group in Xinjiang].

AGT GNB3

2.06e-05465219103106
Pubmed

Association between a functional polymorphism in the renin-angiotensin system and completed suicide.

AGT GNB3

2.06e-05465216736244
Pubmed

Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension.

AGT GNB3

3.43e-05565211910300
Pubmed

Variation in Renin-Angiotensin system and salt-sensitivity genes and the risk of diabetes mellitus associated with the use of thiazide diuretics.

AGT GNB3

3.43e-05565219247266
Pubmed

Genetic associations with mountain sickness in Han and Tibetan residents at the Qinghai-Tibetan Plateau.

AGT GNB3

3.43e-05565220570668
Pubmed

Interactions between five candidate genes and antihypertensive drug therapy on blood pressure.

AGT GNB3

3.43e-05565216314886
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

DENND4A KIF26B ROBO1 PCM1 VCPIP1

4.60e-0520965536779422
Pubmed

Clinical and genetic associations with hypertriglyceridemic waist in a Canadian aboriginal population.

AGT GNB3

5.13e-05665216276364
Pubmed

The contribution of six polymorphisms to cardiovascular risk in a Dutch high-risk primary care population: the HIPPOCRATES project.

AGT GNB3

5.13e-05665219242491
Pubmed

Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene.

RELN ASTN1

5.13e-05665218384059
Pubmed

Sex-specific effect of the alpha-adducin (G460W) and AGTR1 (A1166C) polymorphism on carotid intima-media thickness.

AGT GNB3

5.13e-05665219620885
Pubmed

The association between arterial stiffness and the angiotensin II type 1 receptor (A1166C) polymorphism is influenced by the use of cardiovascular medication.

AGT GNB3

5.13e-05665219145770
Pubmed

SNP-by-fitness and SNP-by-BMI interactions from seven candidate genes and incident hypertension after 20 years of follow-up: the CARDIA Fitness Study.

AGT GNB3

5.13e-05665220944660
Pubmed

The role of Robo3 in the development of cortical interneurons.

RELN ROBO1

5.13e-05665219366869
Pubmed

The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age.

AGT GNB3

5.13e-05665219779330
Pubmed

Genetic profile of ischemic cerebrovascular disease and carotid stenosis.

AGT GNB3

5.13e-05665218325076
Pubmed

Association study of eight candidate genes with renin status in mild-to-moderate hypertension in patients of African ancestry.

AGT GNB3

7.18e-05765211447495
Pubmed

Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.

RELN WDFY3

7.18e-05765236897941
Pubmed

Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex.

RELN PTPRZ1

7.18e-05765214757526
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

CCPG1 STARD9 DACH1 ANO7 TECPR1

7.70e-0523365537704626
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

UBAP2 KIF26B ROBO1 PCM1 VCPIP1

1.20e-0425665533397691
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PTPRZ1 AGT MERTK CD163 ADGRL4

1.22e-0425765516335952
Pubmed

An introduction of genetics in otosclerosis: a systematic review.

RELN AGT

1.23e-04965224170657
Pubmed

Prevalence of common disease-associated variants in Asian Indians.

AGT GNB3

1.23e-04965218248681
Pubmed

Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.

ROBO1 USH2A

1.23e-04965223144817
Pubmed

Gene-load score of the renin-angiotensin-aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia.

AGT GNB3

1.23e-04965218413308
Pubmed

Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair.

AGT GNB3

1.87e-041165220537417
Pubmed

Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population.

AGT GNB3

1.87e-041165219779464
Pubmed

Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.

AGT GNB3

1.87e-041165220577119
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DENND4A IRS4 UBAP2 KIF26B STARD9 RFX7 PCM1 VCPIP1

1.98e-0486165836931259
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

RELN AGT ASTN1 GNB3 ADCYAP1R1

2.50e-0430065519086053
Pubmed

Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.

RELN ROBO1

2.65e-041365231070778
Pubmed

The environmental and genetic evidence for the association of hyperlipidemia and hypertension.

AGT GNB3

2.65e-041365219155782
Pubmed

Genome-wide analysis of gene transcription in the hypothalamus.

IRS4 PTPRZ1

2.65e-041365215870395
Pubmed

Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.

ROBO1 WDFY3

3.08e-041465227648578
Pubmed

[Association of genetic factors with clinical peculiarities of hypertensive disease in patients with burdened familial anamnesis].

AGT GNB3

3.08e-041465219254215
Pubmed

Analysis of several hundred genetic polymorphisms may improve assessment of the individual genetic burden for coronary artery disease.

AGT GNB3

3.56e-041565212446192
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTSL1 SSPOP CCN3

3.82e-047565320637190
Pubmed

The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.

AGT GNB3

4.06e-041665215824464
Pubmed

Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation.

RELN ROBO1

4.59e-041765217376983
Pubmed

Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool.

RELN DACH1

4.59e-041765218521945
Pubmed

Association of single-nucleotide polymorphisms from 17 candidate genes with baseline symptom-limited exercise test duration and decrease in duration over 20 years: the Coronary Artery Risk Development in Young Adults (CARDIA) fitness study.

AGT GNB3

4.59e-041765220952631
Pubmed

Development of a diagnostic genetic test for simplex and autosomal recessive retinitis pigmentosa.

MERTK USH2A

5.16e-041865220591486
Pubmed

Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.

RELN ALX1

5.76e-041965233723434
Pubmed

The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.

CEP76 PCM1

5.76e-041965224421332
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ASTN1 WDFY3 TECPR1

5.90e-048765312465718
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

CHAF1B RELN ROBO1 ASTN1 CHD6 WDFY3 MERTK PCM1 VCPIP1

6.20e-04128565935914814
Pubmed

Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

ADAMTSL1 DACH1 LINC00474

6.31e-048965324529757
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

IRS4 LRRK2 DNAH5 VCPIP1

6.33e-0420865433230847
Pubmed

Can we predict top-level sports performance in power vs endurance events? A genetic approach.

AGT GNB3

6.39e-042065220459474
Pubmed

FOXG1 Orchestrates Neocortical Organization and Cortico-Cortical Connections.

RELN ROBO1

6.39e-042065230392794
Pubmed

Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels.

RELN ROBO1

6.39e-042065229961574
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ADAMTSL1 SSPOP GPRIN2

1.02e-031056539628581
Pubmed

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.

CHAF1B UBAP2 ZC3HC1 GNB3 CBLB

1.13e-0341965533001583
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

CHAF1B ZC3HC1 CHD6 CEP76 PCM1 VCPIP1

1.30e-0364565625281560
Pubmed

EBF2 determines and maintains brown adipocyte identity.

RELN AGT

1.35e-032965223499423
Pubmed

Impaired Interneuron Development after Foxg1 Disruption.

RELN ROBO1

1.35e-032965226620267
Pubmed

Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain.

RELN ROBO1

1.45e-033065217470284
Pubmed

Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex.

RELN SECTM1

1.45e-033065218055048
Pubmed

Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.

CEP76 PCM1

1.54e-033165222261722
Pubmed

A large-scale candidate gene association study of age at menarche and age at natural menopause.

AGT ACVR1C GNB3 PCM1

1.77e-0327565420734064
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

PTPRZ1 STARD9 LRRK2 ALPK2 ADCYAP1R1 ADGRL4

1.77e-0368665629987050
Pubmed

The genomic basis of cerebral palsy: a HuGE systematic literature review.

AGT GNB3

1.86e-033465219238444
Cytoband1q44

OR2W3 KIF26B OR2L5

5.25e-041106531q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2W3 KIF26B OR2L5

8.15e-04128653chr1q44
Cytoband15q21.1

SECISBP2L CCPG1

1.27e-033765215q21.1
GeneFamilyFibronectin type III domain containing

PTPRZ1 ROBO1 ASTN1 MERTK USH2A

4.68e-05160455555
GeneFamilyWD repeat domain containing

CHAF1B EML5 WDFY3 GNB3 ARPC1B

4.68e-04262455362
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

ADAMTSL1 ROBO1 MERTK ALPK2

6.79e-04161454593
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_1000

DENND4A ADAMTSL1 IRS4 ALX1 KIF26B PTPRZ1 DACH1 ROBO1 ALG11 ASTN1 RFX7 VCPIP1

3.14e-068366012gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_top-relative-expression-ranked_500

ADAMTSL1 IRS4 ALX1 KIF26B DACH1 ROBO1 ASTN1 RFX7

2.61e-05428608gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_500_k-means-cluster#4

EML5 PTPRZ1 DACH1 CEP76 ADCYAP1R1

4.27e-05137605Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_500_K4
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN KIF26B ROBO1 USH2A DNAH5 SSPOP

2.65e-071846462cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN KIF26B ROBO1 USH2A DNAH5 SSPOP

2.65e-07184646ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN KIF26B ROBO1 USH2A DNAH5 SSPOP

2.65e-071846462b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue-3|TCGA-Breast / Sample_Type by Project: Shred V9

KLHL29 STARD9 ACVR1C ANGPTL7 ADCYAP1R1

5.18e-061746457f8f5fafae08676d2b90cab9802c3c9320f1370e
ToppCellTCGA-Breast-Solid_Tissue_Normal|TCGA-Breast / Sample_Type by Project: Shred V9

KLHL29 STARD9 ACVR1C ANGPTL7 ADCYAP1R1

5.18e-06174645e2f240d60bffbe8e6d60f0bb405b231bd3c96875
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PTPRZ1 LRRK2 ANGPTL7 ARPC1B

5.18e-06174645667035a11b68745fa8446d6c68214713be42710f
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue|TCGA-Breast / Sample_Type by Project: Shred V9

KLHL29 STARD9 ACVR1C ANGPTL7 ADCYAP1R1

5.18e-061746450f3ec0d0d4344e10c9b48adc9174123f6402dc51
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue|TCGA-Breast / Sample_Type by Project: Shred V9

KLHL29 STARD9 ACVR1C ANGPTL7 ADCYAP1R1

5.18e-061746451aadbf2642b6d1320ceabd92e6ff59e11f16c315
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SECISBP2L RELN PTPRZ1 ANGPTL7 ARPC1B

7.16e-061866456f88b68735d0f7c9904eb8413e6007910d556185
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 DOK6 LRRK2 WDFY3 ALPK2

7.35e-061876459d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOK6 ALX1 EML5 DACH1 ROBO1

8.14e-06191645c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOK6 ALX1 EML5 DACH1 ROBO1

8.14e-06191645cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UMODL1 PTPRZ1 LRRK2 MERTK ACVR1C

8.35e-0619264525460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCellCOVID-19-kidney-Fibroblast-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

KLHL29 DOK6 ADAMTSL1 ALX1 ROBO1

9.00e-061956453d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ANO7 WDFY3 ALPK2 ADCYAP1R1

5.81e-051466445b2608b56204dda9a773988f42ff00a9fa743a39
ToppCellRV-16._Neuronal|World / Chamber and Cluster_Paper

RELN GPR35 PTPRZ1 AGT

6.29e-051496443a2f8c4173dcf9e3f8d3b8ffddbc597098adf7a9
ToppCellRV-16._Neuronal|RV / Chamber and Cluster_Paper

RELN GPR35 PTPRZ1 AGT

6.97e-05153644bed8bbf5c5cbfbf46a816066da472c3fdddecb5d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO1 ACVR1C CBLB CCN3

7.33e-0515564482e602f31981c6b48abff2a04b2ab5d26d4462a2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROBO1 ACVR1C CBLB CCN3

7.33e-05155644979c1d53b435a82c57d16707eed8ba7346326866
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CHAF1B UMODL1 KIF26B TKTL1

7.89e-051586441bf692f1e85f677cd62805437b7a59cfaf3b0449
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IRS4 UMODL1 DACH1 ADGRL4

7.89e-0515864478b48b110b777bcc4c07cd23388bee911c0231d6
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF26B PTPRZ1 ACVR1C MUC5AC

9.56e-0516664460060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF26B PTPRZ1 ACVR1C MUC5AC

9.56e-05166644ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIF26B PTPRZ1 ACVR1C MUC5AC

9.56e-051666444586d6725403f879fc96f67be579022587ce1906
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 DOK6 AGT DACH1

9.78e-05167644e228b8373ffd4436e6b944e26d0fadf3ac289b21
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 DOK6 AGT DACH1

9.78e-051676447cb1b11e8e24a10115e46ffbb74889e672a7a026
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 DOK6 AGT DACH1

9.78e-05167644bb53a478b5d821d6d82c15bc4ed075b67682457c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOK6 ADAMTSL1 DACH1 ROBO1

1.00e-04168644d19a115365c5415e51c039718d7669de788fcf33
ToppCell390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|390C / Donor, Lineage, Cell class and subclass (all cells)

WDFY3 MERTK CD163 SECTM1

1.02e-041696442c851b2703c7b8b656026f996f5fc027e4a79b36
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOK6 ADAMTSL1 PTPRZ1 DACH1

1.05e-04170644fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage|390C / Donor, Lineage, Cell class and subclass (all cells)

EML5 SOWAHD MERTK CD163

1.05e-041706443a7121d045f9ae54583b0f5f7436abf3665a1bce
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOK6 ADAMTSL1 PTPRZ1 DACH1

1.05e-0417064403044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCellClub-club-7|World / Class top

COLEC11 EML5 ADCYAP1R1

1.08e-0464643df413c5328966480479c41826461c4d817fbe33d
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

KLHL29 RELN IRS4 PTPRZ1

1.12e-041736446fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Pcdh11x|Hippocampus / BrainAtlas - Mouse McCarroll V32

ANO7 CTRL ALPK2

1.13e-0465643d90513969c0147c48403ce0155580a97f44ba716
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Pcdh11x-Inhibitory_Neuron.Gad1Gad2_Sst.Pcdh11x_(Interneuron,_OLM4_(Dentate_enriched?))-|Hippocampus / BrainAtlas - Mouse McCarroll V32

ANO7 CTRL ALPK2

1.13e-0465643f7f4560363bacad033154a402d7593aa5ebfb2e7
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Pcdh11x-Inhibitory_Neuron.Gad1Gad2_Sst.Pcdh11x_(Interneuron,_OLM4_(Dentate_enriched?))|Hippocampus / BrainAtlas - Mouse McCarroll V32

ANO7 CTRL ALPK2

1.13e-0465643d6ad7b63bc09fdc05a1245bf66d3c5a46e622ba5
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Htr1a_(Neuron.Slc17a6.Htr1a)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

IRS4 ANO7 TKTL1

1.23e-0467643be6853b5bf254063f02a4c478fd4c3fef68cb77a
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Htr1a_(Neuron.Slc17a6.Htr1a)|Hippocampus / BrainAtlas - Mouse McCarroll V32

IRS4 ANO7 TKTL1

1.23e-04676437483b85423d9d07b01b60927d0fe1b7ccb241d7f
ToppCellILEUM-inflamed-(9)_Enteric_neurons|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

RELN PTPRZ1 ANGPTL7 CCN3

1.25e-04178644d9142151819afb0dc22bfb32a9c9dba5f553067d
ToppCellILEUM-inflamed-(9)_Neuro_cell|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

RELN PTPRZ1 ANGPTL7 CCN3

1.25e-04178644611504b0a9e6318b18fba83787b03f9245c82252
ToppCellwk_08-11-Epithelial-PNS-Late_Schwann|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

PTPRZ1 ANGPTL7 ARPC1B CCN3

1.25e-04178644a7301c0bba03d10feacc02e3f929d9a9235fd25b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 DOK6 LRRK2 ALPK2

1.28e-0417964458ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ALX1 STARD9 DACH1 CBLB

1.31e-04180644280ff5c8f292be1b88120db5ff1788b750644856
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PTPRZ1 ANGPTL7 ARPC1B

1.31e-04180644b294f9db1e2ff51c94cde64fae4c2b057c0030a1
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ALX1 STARD9 DACH1 CBLB

1.31e-04180644fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SECISBP2L RELN PTPRZ1 ARPC1B

1.31e-0418064438490017dd590e3fcfa7e88d8d15235d55f90cf1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOK6 ADAMTSL1 ALX1 DACH1

1.33e-041816446d1f1ad35778a2a227f966f11f6edd8e89452576
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 LRRK2 WDFY3 ALPK2

1.36e-041826445e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN PTPRZ1 AGT ROBO1

1.36e-04182644d3a037268f026eb2f84428b1821022503cef7756
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOK6 COLEC11 ADAMTSL1 DACH1

1.36e-0418264444764676ed3f51ba171ce63f669390392fa50a43
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOK6 COLEC11 ADAMTSL1 DACH1

1.36e-04182644d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC11 ADAMTSL1 PTPRZ1 CEP76

1.39e-041836440e8fb371d8eac777451c76f41d53577f5dfb740d
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PTPRZ1 ANGPTL7 ARPC1B

1.39e-04183644547b1fb9f9940cfc8d6e351d96acc0da44def57e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 DACH1 ROBO1 CBLB

1.39e-041836447c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC11 ADAMTSL1 PTPRZ1 CEP76

1.39e-04183644cbc3b00faa7e4e0dbbbc8ee105467c65241c7470
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PTPRZ1 ANGPTL7 ARPC1B

1.42e-04184644226ccac00ac1c3a0ad7283785fd14312320e0ca6
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOWAHD ROBO1 ASTN1 QRICH2

1.42e-041846441c857126c0ea0671f0d60b048efca288d348d653
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 COLEC11 RELN ADCYAP1R1

1.45e-04185644f814ec9d4ade717a0109398e9768d0d66f09317b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RELN KIF26B ROBO1 ALPK2

1.45e-0418564434fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 COLEC11 RELN ADCYAP1R1

1.45e-0418564440e958511790e84321da5ccf735f9974c06a0263
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 COLEC11 RELN ADCYAP1R1

1.45e-041856445f2eeba80aff145e85cfd81e2890a155406badb9
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PTPRZ1 ACVR1C USH2A ADGRL4

1.45e-0418564410da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RELN KIF26B ROBO1 ALPK2

1.45e-041856448816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell3'_v3-lymph-node_spleen-Myeloid_Monocytic-Nonclassical_monocytes|lymph-node_spleen / Manually curated celltypes from each tissue

UMODL1 LRRK2 MERTK SECTM1

1.48e-04186644d7da5edb2ee36f96cdd7e27eb9afcc1cbfd52bb6
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SECISBP2L ADAMTSL1 LRRK2 DNAH5

1.48e-041866442ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 DOK6 LRRK2 ALPK2

1.48e-04186644f28d72b47624b69a580b4429e2be560a26898591
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

ANO7 QRICH2 ADGRL4 TECPR1

1.48e-041866442e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

ANO7 QRICH2 ADGRL4 TECPR1

1.48e-04186644c3449e54454009973818fc1101933c6f0168258c
ToppCelldroplet-Liver-HEPATOCYTES-1m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 COLEC11 RELN DACH1

1.51e-04187644b6ecf55014f246461bf1ca12f24cb4d046661fa4
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN KIF26B ROBO1 ADCYAP1R1

1.51e-0418764485f1678338a47d91e296f0620d4887f057eb7e70
ToppCelldroplet-Liver-HEPATOCYTES-1m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 COLEC11 RELN DACH1

1.51e-041876449fb15f24b9b364b0c4704ec98aec236eaec5411c
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOK6 DACH1 ROBO1 CBLB

1.51e-04187644a9316e2818217ec5feae9cf8816f7249803caee6
ToppCelldroplet-Liver-HEPATOCYTES-1m-Mesenchymal|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 COLEC11 RELN DACH1

1.51e-04187644e6afbaed352310a1cb49571a2aae18be1f533c9a
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PTPRZ1 ANGPTL7 ARPC1B

1.54e-04188644ccd2541892112a7a303f766adf9a7afeb754498c
ToppCellLPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTSL1 DACH1 MERTK ADGRL4

1.57e-04189644e82211b9dc7540e7a183be2cbcfae39fdf503949
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOK6 ALX1 DACH1 ROBO1

1.57e-04189644c734e5693808a0333139e87bd5be2597a9252afe
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 ALX1 KIF26B DACH1

1.61e-041906442306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANO7 QRICH2 ADGRL4 TECPR1

1.61e-04190644d0297d678498e346e56cf95fe9e3db7d3ad3b837
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 ALX1 KIF26B DACH1

1.61e-041906441f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PTPRZ1 LRRK2 MERTK ACVR1C

1.61e-041906441bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 ALX1 KIF26B DACH1

1.64e-04191644a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 ADAMTSL1 DACH1 ROBO1

1.64e-04191644a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 KIF26B LRRK2 ALPK2

1.64e-041916441cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellNS-critical-d_0-4|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GPR35 MERTK MUC5AC CD163

1.64e-04191644769942a6a31c13c583dc38e8a762df2f5c06c2fb
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 ADAMTSL1 DACH1 ROBO1

1.64e-041916448f6d592edc32fdb901af30501d4360512334e8c2
ToppCellStriatum-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)-|Striatum / BrainAtlas - Mouse McCarroll V32

GPR35 ANO7 ANGPTL7

1.66e-0474643e89506bd854a43b80f839ace36f7a3eaa8437215
ToppCellStriatum-Hematopoietic-MICROGLIA-MI2(C1qb)|Striatum / BrainAtlas - Mouse McCarroll V32

GPR35 ANO7 ANGPTL7

1.66e-04746430dbce0b36eaf0c7a8b623478c85d1cac82c6693a
ToppCellStriatum-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)|Striatum / BrainAtlas - Mouse McCarroll V32

GPR35 ANO7 ANGPTL7

1.66e-0474643093575ea862f3724d236817f04d98cc06b8addf0
ToppCellStriatum-Hematopoietic-MICROGLIA|Striatum / BrainAtlas - Mouse McCarroll V32

GPR35 ANO7 ANGPTL7

1.66e-047464389effada90fbfef1844a905d3f82e9d16666eea5
ToppCellStriatum-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)--|Striatum / BrainAtlas - Mouse McCarroll V32

GPR35 ANO7 ANGPTL7

1.66e-0474643b14a950b90791a4cc5ffd29eb75a524abdd382da
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 ALX1 KIF26B DACH1

1.67e-041926449093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRZ1 AGT MERTK ADCYAP1R1

1.67e-04192644d2161842a38146261847fc9061ba9322e0f087e0
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRZ1 AGT MERTK ADCYAP1R1

1.67e-04192644261211a86e6f63b09c2ddce1d2d9257d311f1770
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 ALX1 KIF26B DACH1

1.67e-041926449ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellwk_08-11-Mesenchymal-Fibroblast-Mesenchymal_3|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RELN ADAMTSL1 ALX1 KIF26B

1.67e-04192644d88753b200d9c8da6716222d697ddf0a1548d6c8
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN KIF26B ROBO1 ADCYAP1R1

1.67e-0419264467d6230e32d446dcb12047fae2c3f1faa80dd720
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN KIF26B ROBO1 ADCYAP1R1

1.67e-04192644dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

UMODL1 SH2D7 USH2A GPRIN2

1.71e-04193644315840bc48899f3a36d57b19197509de19716e3d
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN PTPRZ1 ANGPTL7 ARPC1B

1.71e-041936443ea6b103e35bbb276e95301999618558fa3e38b1
DiseaseIGA Glomerulonephritis

AGT MERTK CD163

4.35e-0534593C0017661
DiseaseEssential hypertension

AGT GNB3

1.75e-0410592cv:C0085580
DiseaseEssential hypertension, genetic

AGT GNB3

1.75e-0410592cv:CN305331
DiseaseHYPERTENSION, ESSENTIAL

AGT GNB3

1.75e-0410592145500
DiseaseInternal Carotid Artery Diseases

AGT CD163

2.14e-0411592C0750986
DiseaseArterial Diseases, Common Carotid

AGT CD163

2.14e-0411592C0750987
DiseaseCarotid Atherosclerosis

AGT CD163

2.14e-0411592C0577631
DiseaseExternal Carotid Artery Diseases

AGT CD163

2.14e-0411592C0600178
DiseaseCarotid Artery Diseases

AGT CD163

2.14e-0411592C0007273
DiseaseEssential Hypertension

AGT GNB3

2.56e-0412592C0085580
Diseaseskin melanoma (is_marker_for)

CHAF1B AGT

3.02e-0413592DOID:8923 (is_marker_for)
Diseasegastric ulcer (implicated_via_orthology)

AGT MUC5AC

3.52e-0414592DOID:10808 (implicated_via_orthology)
DiseaseSchizophrenia

RELN EML5 PTPRZ1 GNB3 CTRL PCM1 CD163 ADCYAP1R1

3.58e-04883598C0036341
Diseasecarotid artery disease (is_implicated_in)

AGT GNB3

8.85e-0422592DOID:3407 (is_implicated_in)
Diseasenon-alcoholic fatty liver disease, type 2 diabetes mellitus

ADAMTSL1 ROBO1 ARPC1B

1.41e-03110593EFO_0003095, MONDO_0005148
Diseasetemporal lobe epilepsy (biomarker_via_orthology)

PTPRZ1 AGT

1.76e-0331592DOID:3328 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
LEAGWSECGTLMQSN

UMODL1

1036

Q5DID0
WAGNASGGSVVTSCM

ALX1

226

Q15699
SPDTMNGSWSSEGCE

ADGRL4

376

Q9HBW9
LVGSCSDVVMVNSSW

ALG11

246

Q2TAA5
WGSSITDSMICAGGA

CTRL

191

P40313
GESENSGMSQCWETA

ALPK2

501

Q86TB3
FGELMFESSSSCGWV

ARPC1B

191

O15143
QTEGACWASVMLTNG

ACVR1C

41

Q8NER5
CWATDGNLMASASVD

CHAF1B

136

Q13112
VMTCGTDGAITFWES

CEP76

411

Q8TAP6
MNSSVGSSDGSWDKE

DACH1

371

Q9UI36
QEATMSSLWCSGTGD

ASTN1

991

O14525
GWKTGCSLMGASVDS

AGT

251

P01019
MAGWTADDSNLNTTC

DENND4A

1466

Q7Z401
TDGWRASQAGSETLM

QRICH2

61

Q9H0J4
FCDMETSGGGWTIIQ

ANGPTL7

161

O43827
ERWAMTSETSSGSHC

ANO7

36

Q6IWH7
LNSGGRWDSEVMAST

NAXE

41

Q8NCW5
SIGVSCMNEIGWSAV

MERTK

356

Q12866
CAASGFTVSSNEMSW

IGHV3-38

41

A0A0C4DH36
CAASGFTVSSNEMSW

IGHV3-38-3

41

P0DTE1
WLSEMSAGSEGEQSC

KIF26B

1281

Q2KJY2
LMCTSCLTAWQESDG

CBLB

391

Q13191
DWTECSTSCGEGTQT

ADAMTSL1

796

Q8N6G6
TSNWGSSFSEKSGCM

LINC00474

26

Q9P2X8
TMATWGGSTQCALDE

PCM1

886

Q15154
GSWMIGSINSCAHTV

OR2L5

146

Q8NG80
SVTWGCGVANSLAMS

OR2W3

146

Q7Z3T1
STNSTERNVMWGGCG

LRRK2

2306

Q5S007
TADGMAVATGSWDSF

GNB3

321

P16520
VVASCSEMSGLWNVS

MUC5AC

5081

P98088
ITFHWGKCNMSSDGS

PTPRZ1

126

P23471
MNGTYNTCGSSDLTW

GPR35

1

Q9HC97
MGVVSRNCTEDGWSE

ADCYAP1R1

111

P41586
WMSLEGGSTCTECGI

RELN

2906

P78509
MSENSSDSDSSCGWT

CCPG1

1

Q9ULG6
TEWTACSKSCGMGFS

CCN3

211

P48745
STWFTFESGRMCDTG

DOK6

191

Q6PKX4
WHGESAMDLSCSSEG

CHD6

2211

Q8TD26
SAECILSGNTAHWSM

CR1L

451

Q2VPA4
VASGGWNDVACHTTM

COLEC11

246

Q9BWP8
SCTFGGIWSSGVDML

LINC01560

31

Q8TB33
EMAFSGTSTGDVCIW

EML5

876

Q05BV3
WSSTVGNVSTMGGSD

GPRIN2

91

O60269
SSAGSGRIWMDHVSC

CD163

106

Q86VB7
GNVAGLCSWTKAMAS

DNAH5

3401

Q8TE73
TGSSCPGAMWLSTAT

IRS4

46

O14654
NGGCTASVSKSAWTM

USH2A

4426

O75445
NCWHTSAAGAGMTLA

SSPOP

4481

A2VEC9
ESSMCAGGVNWSNVT

SECISBP2L

301

Q93073
SEAHTAWCGSVRSMA

STARD9

2401

Q9P2P6
GAEEWEMESGSGCTN

SOWAHD

241

A6NJG2
LSVCGWACSSSLESM

ZC3HC1

251

Q86WB0
EGNSDTTSWETVGCK

UBAP2

91

Q5T6F2
GGTSTVVCVWEMGTS

WDFY3

3096

Q8IZQ1
GVVSVSWGENTVMSC

SECTM1

41

Q8WVN6
MWSDASGLQECTKAG

TECPR1

846

Q7Z6L1
FCLMGDGESSEGSVW

TKTL2

151

Q9H0I9
GCSDAMGSLGATWRQ

SH2D7

316

A6NKC9
CSESMNSMTSSGFEW

RFX7

1336

Q2KHR2
DLESSVTGSMINGWG

ROBO1

1361

Q9Y6N7
GMSNLTACNWCHGTS

VCPIP1

531

Q96JH7
FCLSNWTSGAGFSEM

nan

61

Q6ZWC4
FCLMSDGESSEGSVW

TKTL1

121

P51854
SAGSLGMGAVSWSES

ZNF219

36

Q9P2Y4
SGGMESGVTLADVWC

KLHL29

641

Q96CT2