Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	L-ascorbic acid transmembrane transporter activity	SLC23A2 SLC23A1	5.91e-05	2	154	2	GO:0015229
GeneOntologyMolecularFunction	NADH oxidase H202-forming activity	DUOX2 DUOX1	5.91e-05	2	154	2	GO:0106293
GeneOntologyMolecularFunction	L-ascorbate:sodium symporter activity	SLC23A2 SLC23A1	5.91e-05	2	154	2	GO:0008520
GeneOntologyMolecularFunction	vitamin transmembrane transporter activity	SLC44A4 SLC2A3 SLC23A2 SLC23A1	1.65e-04	36	154	4	GO:0090482
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulator activity	FLT3 PIK3IP1 WDR91	3.37e-04	18	154	3	GO:0035014
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC44A4 SLC2A3 SLC4A2 SLC6A7 SLC16A4 SLC16A3 SLC51A SLC23A2 SLC23A1	4.62e-04	293	154	9	GO:0008514
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC44A4 SLC4A2 SLC6A7 CLCN6 SLC16A4 SLC16A3 SLC18A3 SLC23A2 SLC23A1	4.97e-04	296	154	9	GO:0015291
GeneOntologyMolecularFunction	NADPH oxidase H202-forming activity	DUOX2 DUOX1	5.82e-04	5	154	2	GO:0106294
GeneOntologyMolecularFunction	netrin receptor activity	UNC5A UNC5CL	8.69e-04	6	154	2	GO:0005042
GeneOntologyCellularComponent	INO80-type complex	GON4L INO80 SRCAP YY1AP1	5.58e-05	28	158	4	GO:0097346
GeneOntologyCellularComponent	Ino80 complex	GON4L INO80 YY1AP1	2.67e-04	17	158	3	GO:0031011
Domain	TF_fork_head_CS_2	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXG1	3.61e-05	46	153	5	IPR030456
Domain	TF_fork_head_CS_1	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXG1	4.02e-05	47	153	5	IPR018122
Domain	FH	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXG1	4.93e-05	49	153	5	SM00339
Domain	FORK_HEAD_1	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXG1	4.93e-05	49	153	5	PS00657
Domain	FORK_HEAD_2	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXG1	4.93e-05	49	153	5	PS00658
Domain	Fork_head_dom	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXG1	4.93e-05	49	153	5	IPR001766
Domain	FORK_HEAD_3	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXG1	4.93e-05	49	153	5	PS50039
Domain	Forkhead	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXG1	4.93e-05	49	153	5	PF00250
Domain	ZU5	PIDD1 UNC5A UNC5CL	6.20e-05	10	153	3	PS51145
Domain	DUOX1	DUOX2 DUOX1	6.67e-05	2	153	2	IPR029595
Domain	ZU5	PIDD1 UNC5A UNC5CL	1.12e-04	12	153	3	PF00791
Domain	ZU5_dom	PIDD1 UNC5A UNC5CL	1.12e-04	12	153	3	IPR000906
Domain	uDENN	DENND2B DENND4B DENND2C	1.84e-04	14	153	3	SM00800
Domain	Xan_ur_permease	SLC23A2 SLC23A1	1.99e-04	3	153	2	PF00860
Domain	Xant/urac/vitC	SLC23A2 SLC23A1	1.99e-04	3	153	2	IPR006043
Domain	Keratin_matx	KRTAP3-3 KRTAP3-2	1.99e-04	3	153	2	PF04579
Domain	Orai-1	ORAI1 ORAI3	1.99e-04	3	153	2	PF07856
Domain	CRAC_channel	ORAI1 ORAI3	1.99e-04	3	153	2	IPR012446
Domain	Stereocilin-rel	OTOA MSLN	1.99e-04	3	153	2	IPR026664
Domain	uDENN	DENND2B DENND4B DENND2C	2.28e-04	15	153	3	PF03456
Domain	CAP	CLEC18A CLEC18B CLEC18C	2.28e-04	15	153	3	PF00188
Domain	SCP	CLEC18A CLEC18B CLEC18C	2.28e-04	15	153	3	SM00198
Domain	Allrgn_V5/Tpx1	CLEC18A CLEC18B CLEC18C	2.28e-04	15	153	3	IPR001283
Domain	-	CLEC18A CLEC18B CLEC18C	2.28e-04	15	153	3	3.40.33.10
Domain	CAP_domain	CLEC18A CLEC18B CLEC18C	2.28e-04	15	153	3	IPR014044
Domain	DENN	DENND2B DENND4B DENND2C	2.79e-04	16	153	3	SM00799
Domain	DENN	DENND2B DENND4B DENND2C	2.79e-04	16	153	3	PF02141
Domain	dDENN	DENND2B DENND4B DENND2C	2.79e-04	16	153	3	PF03455
Domain	UDENN	DENND2B DENND4B DENND2C	2.79e-04	16	153	3	PS50946
Domain	DDENN	DENND2B DENND4B DENND2C	2.79e-04	16	153	3	PS50947
Domain	dDENN	DENND2B DENND4B DENND2C	2.79e-04	16	153	3	SM00801
Domain	dDENN_dom	DENND2B DENND4B DENND2C	2.79e-04	16	153	3	IPR005112
Domain	uDENN_dom	DENND2B DENND4B DENND2C	2.79e-04	16	153	3	IPR005113
Domain	DENN	DENND2B DENND4B DENND2C	2.79e-04	16	153	3	PS50211
Domain	DENN_dom	DENND2B DENND4B DENND2C	2.79e-04	16	153	3	IPR001194
Domain	Tscrpt_reg_SKI_SnoN	SKI SKIL	3.96e-04	4	153	2	IPR023216
Domain	c-SKI_SMAD_bind	SKI SKIL	3.96e-04	4	153	2	PF08782
Domain	Keratin_matx	KRTAP3-3 KRTAP3-2	3.96e-04	4	153	2	PD010562
Domain	c-SKI_SMAD_bind	SKI SKIL	3.96e-04	4	153	2	SM01046
Domain	c-SKI_SMAD4-bd_dom	SKI SKIL	3.96e-04	4	153	2	IPR014890
Domain	Keratin_matx	KRTAP3-3 KRTAP3-2	6.56e-04	5	153	2	IPR007659
Domain	UPA	UNC5A UNC5CL	6.56e-04	5	153	2	PF17217
Domain	UPA	UNC5A UNC5CL	6.56e-04	5	153	2	IPR033772
Domain	Ig_I-set	MAG HSPG2 MYLK LRFN3 UNC5A LSAMP CDON	9.81e-04	190	153	7	IPR013098
Domain	I-set	MAG HSPG2 MYLK LRFN3 UNC5A LSAMP CDON	9.81e-04	190	153	7	PF07679
Domain	Notch_dom	PAPPA NOTCH2	1.36e-03	7	153	2	IPR000800
Domain	NAD_binding_6	DUOX2 DUOX1	1.36e-03	7	153	2	PF08030
Domain	FAD_binding_8	DUOX2 DUOX1	1.36e-03	7	153	2	PF08022
Domain	Notch	PAPPA NOTCH2	1.36e-03	7	153	2	PF00066
Domain	Ski_Sno	SKI SKIL	1.36e-03	7	153	2	PF02437
Domain	-	SKI SKIL	1.36e-03	7	153	2	3.10.260.20
Domain	Transform_Ski	SKI SKIL	1.36e-03	7	153	2	IPR003380
Domain	FAD-bd_8	DUOX2 DUOX1	1.36e-03	7	153	2	IPR013112
Domain	Fe_red_NAD-bd_6	DUOX2 DUOX1	1.36e-03	7	153	2	IPR013121
Domain	NL	PAPPA NOTCH2	1.36e-03	7	153	2	SM00004
Domain	DEATH	PIDD1 UNC5A UNC5CL	1.36e-03	27	153	3	SM00005
Domain	MFS	SPNS1 SLC2A3 SLC16A4 SLC16A3 SLC18A3	1.96e-03	108	153	5	PS50850
Domain	PAS	AHRR PER3 NPAS4	2.25e-03	32	153	3	SM00091
Domain	ZU5	UNC5A UNC5CL	2.31e-03	9	153	2	SM00218
Domain	Death	PIDD1 UNC5A UNC5CL	2.46e-03	33	153	3	PF00531
Domain	PAS	AHRR PER3 NPAS4	2.68e-03	34	153	3	PS50112
Domain	PAS	AHRR PER3 NPAS4	2.68e-03	34	153	3	IPR000014
Domain	An_peroxidase	DUOX2 DUOX1	2.87e-03	10	153	2	PF03098
Domain	Haem_peroxidase_animal	DUOX2 DUOX1	2.87e-03	10	153	2	IPR019791
Domain	Haem_peroxidase	DUOX2 DUOX1	2.87e-03	10	153	2	IPR010255
Domain	PEROXIDASE_3	DUOX2 DUOX1	2.87e-03	10	153	2	PS50292
Domain	-	DUOX2 DUOX1	2.87e-03	10	153	2	1.10.640.10
Domain	DNA-bd_dom_put	SKI SKIL	3.49e-03	11	153	2	IPR009061
Domain	Death_domain	PIDD1 UNC5A UNC5CL	3.69e-03	38	153	3	IPR000488
Domain	DEATH_DOMAIN	PIDD1 UNC5A UNC5CL	3.69e-03	38	153	3	PS50017
Domain	MFS_1	SPNS1 SLC16A4 SLC16A3 SLC18A3	3.69e-03	77	153	4	PF07690
Domain	MFS	SPNS1 SLC16A4 SLC16A3 SLC18A3	3.69e-03	77	153	4	IPR011701
Domain	Ferric_reduct	DUOX2 DUOX1	4.17e-03	12	153	2	PF01794
Domain	-	SKI SKIL	4.17e-03	12	153	2	3.10.390.10
Domain	SAND_dom-like	SKI SKIL	4.17e-03	12	153	2	IPR010919
Domain	Fe3_Rdtase_TM_dom	DUOX2 DUOX1	4.17e-03	12	153	2	IPR013130
Domain	MFS_dom	SPNS1 SLC2A3 SLC16A4 SLC16A3 SLC18A3	4.95e-03	134	153	5	IPR020846
Domain	C-type_lectin_CS	CLEC18A CLEC18B CLEC18C	5.23e-03	43	153	3	IPR018378
Domain	IG	MAG HSPG2 FLT3 MYLK LRFN3 SIRPD UNC5A LSAMP CDON	7.97e-03	421	153	9	SM00409
Domain	Ig_sub	MAG HSPG2 FLT3 MYLK LRFN3 SIRPD UNC5A LSAMP CDON	7.97e-03	421	153	9	IPR003599
Pathway	REACTOME_VITAMIN_C_ASCORBATE_METABOLISM	SLC2A3 SLC23A2 SLC23A1	3.35e-05	8	121	3	M27091
Pathway	REACTOME_VITAMIN_C_ASCORBATE_METABOLISM	SLC2A3 SLC23A2 SLC23A1	4.99e-05	9	121	3	MM14769
Pathway	BIOCARTA_VITCB_PATHWAY	SLC2A3 SLC23A2 SLC23A1	9.68e-05	11	121	3	M15422
Pathway	BIOCARTA_VITCB_PATHWAY	SLC2A3 SLC23A2 SLC23A1	1.28e-04	12	121	3	MM1526
Pubmed	Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXG1	2.49e-09	13	161	5	7957066
Pubmed	Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	6.59e-09	6	161	4	27092474
Pubmed	The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	3.05e-08	8	161	4	8530406
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	5.47e-08	9	161	4	12412011
Pubmed	Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXG1	7.91e-08	24	161	5	11820816
Pubmed	Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.	CLEC18A CLEC18B CLEC18C	9.74e-08	3	161	3	26170455
Pubmed	The C-type lectin-like domain superfamily.	CLEC18A CLEC18B CLEC18C	9.74e-08	3	161	3	16336259
Pubmed	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.	CLEC18A CLEC18B CLEC18C	9.74e-08	3	161	3	33603190
Pubmed	Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXG1	1.21e-07	26	161	5	15857913
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	3.06e-07	13	161	4	16884697
Pubmed	The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.	CLEC18A CLEC18B CLEC18C	3.88e-07	4	161	3	16709836
Pubmed	The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.	DUOX2 DUOX1 DUOXA2	3.88e-07	4	161	3	22814254
Pubmed	Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.	DUOX2 DUOX1 DUOXA2	3.88e-07	4	161	3	19339556
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	5.80e-07	15	161	4	7689224
Pubmed	Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	5.80e-07	15	161	4	22045912
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	7.71e-07	16	161	4	8861101
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	7.71e-07	16	161	4	10208738
Pubmed	FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.	FOXD4L6 FOXD4L5 FOXD4L4	9.67e-07	5	161	3	12234674
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.62e-06	19	161	4	9895322
Pubmed	Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells.	SLC2A3 SLC23A2 SLC23A1	1.93e-06	6	161	3	18668520
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	2.02e-06	20	161	4	12812790
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PGS1 C12orf56 CAMSAP3 PEX6 GON4L C15orf39 SLC4A2 PRR12 MARF1 PAM YY1AP1 DNA2 DDX11L8 LRRC41	2.24e-06	650	161	14	38777146
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	2.49e-06	21	161	4	9449667
Pubmed	Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	3.03e-06	22	161	4	17389379
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	4.37e-06	24	161	4	29992973
Pubmed	Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	9.60e-06	29	161	4	22972626
Pubmed	Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.	SLC2A3 E2F8 NDRG1	1.14e-05	10	161	3	18194653
Pubmed	Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.	DUOX2 DUOX1	2.13e-05	2	161	2	28633507
Pubmed	Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.	ORAI1 ORAI3	2.13e-05	2	161	2	19887627
Pubmed	Ski/SnoN expression in the sequence metaplasia-dysplasia-adenocarcinoma of Barrett's esophagus.	SKI SKIL	2.13e-05	2	161	2	18261624
Pubmed	A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals.	SLC23A2 SLC23A1	2.13e-05	2	161	2	10395795
Pubmed	Complex formation between proteins encoded by the ski gene family.	SKI SKIL	2.13e-05	2	161	2	8514802
Pubmed	Differential Redox Regulation of Ca²⁺ Signaling and Viability in Normal and Malignant Prostate Cells.	ORAI1 ORAI3	2.13e-05	2	161	2	26445441
Pubmed	N-Glycosylation is required for Na+-dependent vitamin C transporter functionality.	SLC23A2 SLC23A1	2.13e-05	2	161	2	18619416
Pubmed	Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma.	SLC23A2 SLC23A1	2.13e-05	2	161	2	18791929
Pubmed	Notch signaling pathway and Cdx2 expression in the development of Barrett's esophagus.	CDX2 SBNO1	2.13e-05	2	161	2	22449796
Pubmed	Temporo-spacial microanatomical distribution of the murine sodium-dependent ascorbic acid transporters Slc23a1 and Slc23a2 in the kidney throughout development.	SLC23A2 SLC23A1	2.13e-05	2	161	2	28177761
Pubmed	Communication between N terminus and loop2 tunes Orai activation.	ORAI1 ORAI3	2.13e-05	2	161	2	29237733
Pubmed	Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.	DUOX2 DUOX1	2.13e-05	2	161	2	22523549
Pubmed	Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery.	SLC23A2 SLC23A1	2.13e-05	2	161	2	16357110
Pubmed	Isolation of human cDNA clones of ski and the ski-related gene, sno.	SKI SKIL	2.13e-05	2	161	2	2762147
Pubmed	Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.	SLC16A4 SLC16A3	2.13e-05	2	161	2	34822124
Pubmed	Expression of dual oxidases and secreted cytokines in chronic rhinosinusitis.	DUOX2 DUOX1	2.13e-05	2	161	2	23281318
Pubmed	Functional role of conserved transmembrane segment 1 residues in human sodium-dependent vitamin C transporters.	SLC23A2 SLC23A1	2.13e-05	2	161	2	18247577
Pubmed	Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle.	SLC16A4 SLC16A3	2.13e-05	2	161	2	11101640
Pubmed	Proto-oncogene Sno expression, alternative isoforms and immediate early serum response.	SKI SKIL	2.13e-05	2	161	2	9207045
Pubmed	Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response.	DUOX2 DUOX1	2.13e-05	2	161	2	31706280
Pubmed	Human vitamin C (L-ascorbic acid) transporter SVCT1.	SLC23A2 SLC23A1	2.13e-05	2	161	2	10631088
Pubmed	Newly identified Gon4l/Udu-interacting proteins implicate novel functions.	GON4L YY1AP1	2.13e-05	2	161	2	32848183
Pubmed	When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.	DUOX2 DUOXA2	2.13e-05	2	161	2	25761904
Pubmed	A family of mammalian Na+-dependent L-ascorbic acid transporters.	SLC23A2 SLC23A1	2.13e-05	2	161	2	10331392
Pubmed	Heterozygous Mutations of the DUOXA2 and DUOX2 Genes in Dizygotic Twins with Congenital Hypothyroidism.	DUOX2 DUOXA2	2.13e-05	2	161	2	27349010
Pubmed	Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.	DUOX2 DUOX1	2.13e-05	2	161	2	15972824
Pubmed	The transcriptional regulator GON4L is required for viability and hematopoiesis in mice.	GON4L YY1AP1	2.13e-05	2	161	2	33864850
Pubmed	The Dual Oxidase Duox2 stabilized with DuoxA2 in an enzymatic complex at the surface of the cell produces extracellular H2O2 able to induce DNA damage in an inducible cellular model.	DUOX2 DUOXA2	2.13e-05	2	161	2	31513783
Pubmed	Limited Association Between Ascorbate Concentrations and Vitamin C Transporters in Renal Cell Carcinoma Cells and Clinical Samples.	SLC23A2 SLC23A1	2.13e-05	2	161	2	34599650
Pubmed	Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.	DUOX2 DUOX1	2.13e-05	2	161	2	23362256
Pubmed	Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.	DUOX2 DUOX1	2.13e-05	2	161	2	19144650
Pubmed	DUOX2/DUOXA2 Mutations Frequently Cause Congenital Hypothyroidism that Evades Detection on Newborn Screening in the United Kingdom.	DUOX2 DUOXA2	2.13e-05	2	161	2	31044655
Pubmed	Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases.	SLC23A2 SLC23A1	2.13e-05	2	161	2	21733302
Pubmed	Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration.	NDRG1 PML	2.13e-05	2	161	2	23555679
Pubmed	Senescence-induced increases in intracellular oxidative stress and enhancement of the need for ascorbic acid in human fibroblasts.	SLC23A2 SLC23A1	2.13e-05	2	161	2	23613229
Pubmed	Vitamin C transporter gene polymorphisms, dietary vitamin C and serum ascorbic acid.	SLC23A2 SLC23A1	2.13e-05	2	161	2	20588054
Pubmed	Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas.	DUOX2 DUOX1	2.13e-05	2	161	2	11762710
Pubmed	The role of PML in tumor suppression.	TP73 PML	2.13e-05	2	161	2	11832207
Pubmed	Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.	DUOX2 DUOX1	2.13e-05	2	161	2	11822874
Pubmed	Activity of a sodium-dependent vitamin C transporter (SVCT) in MDCK-MDR1 cells and mechanism of ascorbate uptake.	SLC23A2 SLC23A1	2.13e-05	2	161	2	18417304
Pubmed	Promoter analysis of the human ascorbic acid transporters SVCT1 and 2: mechanisms of adaptive regulation in liver epithelial cells.	SLC23A2 SLC23A1	2.13e-05	2	161	2	20471816
Pubmed	Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor.	DUOX2 DUOXA2	2.13e-05	2	161	2	17374849
Pubmed	Gender and sodium-ascorbate transporter isoforms determine ascorbate concentrations in mice.	SLC23A2 SLC23A1	2.13e-05	2	161	2	15333707
Pubmed	Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease.	DUOX2 DUOX1	2.13e-05	2	161	2	18177232
Pubmed	Effects of functional variants of vitamin C transporter genes on apolipoprotein E E4-associated risk of cognitive decline: The Nakajima study.	SLC23A2 SLC23A1	2.13e-05	2	161	2	34780525
Pubmed	Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.	ORAI1 ORAI3	2.13e-05	2	161	2	18420579
Pubmed	SKI controls MDS-associated chronic TGF-β signaling, aberrant splicing, and stem cell fitness.	SKI SKIL	2.13e-05	2	161	2	30249787
Pubmed	A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells.	ORAI1 ORAI3	2.13e-05	2	161	2	20395295
Pubmed	TGF-beta repressors SnoN and Ski are implicated in human colorectal carcinogenesis.	SKI SKIL	2.13e-05	2	161	2	19096149
Pubmed	Clinical significance of the expression of c-Ski and SnoN, possible mediators in TGF-beta resistance, in primary cutaneous melanoma.	SKI SKIL	2.13e-05	2	161	2	18782659
Pubmed	Impact of SLC23A1 and SLC23A2 Polymorphisms on the Risk for Preeclampsia in a Chinese Han Population.	SLC23A2 SLC23A1	2.13e-05	2	161	2	36310070
Pubmed	Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.	DUOX2 DUOX1	2.13e-05	2	161	2	12824283
Pubmed	SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno.	SKI SKIL	2.13e-05	2	161	2	8233802
Pubmed	Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families.	DUOX2 DUOX1	2.13e-05	2	161	2	30375286
Pubmed	DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.	DUOX2 DUOXA2	2.13e-05	2	161	2	24492313
Pubmed	Hierarchal contribution of N- and C-terminal sequences to the differential localization of homologous sodium-dependent vitamin C transporters, SVCT1 and SVCT2, in epithelial cells.	SLC23A2 SLC23A1	2.13e-05	2	161	2	19216494
Pubmed	Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells.	SLC23A2 SLC23A1	2.13e-05	2	161	2	22348976
Pubmed	The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis.	GON4L YY1AP1	2.13e-05	2	161	2	20530203
Pubmed	Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.	SLC23A2 SLC23A1	2.13e-05	2	161	2	10556521
Pubmed	Genetic variation in sodium-dependent ascorbic acid transporters and risk of gastric cancer in Poland.	SLC23A2 SLC23A1	2.13e-05	2	161	2	19243932
Pubmed	DUOX2 and DUOXA2 Variants Confer Susceptibility to Thyroid Dysgenesis and Gland-in-situ With Congenital Hypothyroidism.	DUOX2 DUOXA2	2.13e-05	2	161	2	32425884
Pubmed	Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.	DUOX2 DUOX1	2.13e-05	2	161	2	10806195
Pubmed	Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.	DUOX2 DUOX1	2.13e-05	2	161	2	11514595
Pubmed	Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.	SLC23A2 SLC23A1	2.13e-05	2	161	2	10471399
Pubmed	Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling.	DUOX2 DUOX1	2.13e-05	2	161	2	24161126
Pubmed	Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells.	SLC23A2 SLC23A1	2.13e-05	2	161	2	15993839
Pubmed	Compound Heterozygous Mutations in the DUOX2/DUOXA2 Genes Cause Congenital Hypothyroidism.	DUOX2 DUOXA2	2.13e-05	2	161	2	28541007
Pubmed	Polymorphisms in sodium-dependent vitamin C transporter genes and plasma, aqueous humor and lens nucleus ascorbate concentrations in an ascorbate depleted setting.	SLC23A2 SLC23A1	2.13e-05	2	161	2	24815519
Pubmed	Dual oxidase 2 bidirectional promoter polymorphisms confer differential immune responses in airway epithelia.	DUOX2 DUOXA2	2.13e-05	2	161	2	22592922
Pubmed	Molecular mechanism(s) involved in differential expression of vitamin C transporters along the intestinal tract.	SLC23A2 SLC23A1	2.13e-05	2	161	2	27932501
Pubmed	Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues.	DUOX2 DUOX1	2.13e-05	2	161	2	11443211
Pubmed	NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML.	FLT3 NOTCH2	2.13e-05	2	161	2	24574459
Pubmed	Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.	DUOX2 DUOX1	2.13e-05	2	161	2	10601291
Cytoband	9q21.11	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	3.72e-06	30	161	4	9q21.11
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MAG HSPG2 MYLK LRFN3 UNC5A LSAMP CDON	8.06e-05	161	116	7	593
GeneFamily	ORAI calcium release-activated calcium modulators	ORAI1 ORAI3	1.22e-04	3	116	2	668
GeneFamily	Solute carriers	SLC44A4 SLC2A3 SLC4A2 SLC6A7 SLC16A4 SLC16A3 SLC18A3 SLC51A SLC23A2 SLC23A1	2.30e-04	395	116	10	752
GeneFamily	SKI transcriptional corepressors	SKI SKIL	2.43e-04	4	116	2	748
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND2B DENND4B DENND2C	5.34e-04	25	116	3	504
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 TMPRSS4 DUOX2 SLC44A4 DNAH12 WDR49 FOXG1 MSLN DUOXA2	3.07e-08	190	160	9	2fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell	NS-critical-d_07-13\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DDR1 DHRS3 ABCA13 TMPRSS4 DUOX2 SLC44A4 DENND2B DUOX1 DENND2C	4.38e-08	198	160	9	a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LRRC8E ABCA13 TMPRSS4 DUOX2 DENND2C DUOXA2	2.61e-06	108	160	6	9c7f3e25facfb54ef0be45044999bc36438bbea0
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_submucosal-gland\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LRRC8E ABCA13 TMPRSS4 DUOX2 DENND2C DUOXA2	2.61e-06	108	160	6	75d635fc5bb004418db2e1328c24d96b718f10b1
ToppCell	COPD-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	VMP1 PGS1 CEBPD CFP SLC2A3 NDRG1 NOTCH2	4.70e-06	184	160	7	ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CLEC18A CLEC18B ITGA10 CLEC18C CCN6 SERPINE2 LSAMP	4.87e-06	185	160	7	8ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CLEC18A CLEC18B ITGA10 CLEC18C CCN6 SERPINE2 LSAMP	4.87e-06	185	160	7	b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRRC8E EPHB6 MARS2 PAPPA LSAMP MSLN CDON	5.41e-06	188	160	7	e82104f71bcdab7392fdb076dc3560255964fd9e
ToppCell	COPD-Myeloid-cMonocyte\|COPD / Disease state, Lineage and Cell class	VMP1 PGS1 CEBPD CFP SLC2A3 NDRG1 NOTCH2	5.60e-06	189	160	7	d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	ABCA13 TMPRSS4 SLC44A4 DUOX1 DNAH12 HYDIN TP73	6.00e-06	191	160	7	ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell	Control-Epithelial\|Control / Condition, Lineage and Cell class	ABCA13 TMPRSS4 SLC44A4 DUOX1 DNAH12 HYDIN TP73	6.00e-06	191	160	7	6228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ABCA13 SLC44A4 DUOX1 DNAH12 SLC23A1 HYDIN TP73	6.65e-06	194	160	7	756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CCDC14 ABCA13 E2F8 DUOX1 WDR49 MSLN TP73	6.65e-06	194	160	7	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 DUOX2 SPAG8 SLC44A4 DNAH12 WDR49 HYDIN	6.87e-06	195	160	7	79dc031258579ea328181dda33710dd897f1064a
ToppCell	wk_08-11-Mesenchymal-Mesothelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	MAG ASPG TMEM235 PAPPA SLC51A MSLN CDON	6.87e-06	195	160	7	9016a44b521214546a55a822ebdef5b5312206d2
ToppCell	moderate-Epithelial-Secretory\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DDR1 DHRS3 ABCA13 TMPRSS4 DUOX2 SLC44A4 MSLN	7.59e-06	198	160	7	7d96d7105a849c7280ce87bd76ce130ac47384fd
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CDH26 DHRS3 ABCA13 TMPRSS4 DUOX1 DENND2C WDR49	7.59e-06	198	160	7	19d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DDR1 ABCA13 ASPG TMPRSS4 SLC44A4 SLC51A MSLN	7.85e-06	199	160	7	ec1e110671e7725f752163c7241dbbf638dec2b2
ToppCell	Bronchial_Biopsy-Epithelial\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	DDR1 DHRS3 ABCA13 TMPRSS4 SLC44A4 ARHGAP5 DUOX1	7.85e-06	199	160	7	ef5d8917c8d011184830a0b8197afc6266707b37
ToppCell	Bronchial-10x5prime-Epithelial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DDR1 ABCA13 TMPRSS4 SLC44A4 DUOX1 DNAH12 MSLN	8.11e-06	200	160	7	d3ee5f79513e2ac02ad3329b59e6290d457c44d2
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CDH26 DUOX2 SPAG8 SLC44A4 HYDIN TP73 DUOXA2	8.11e-06	200	160	7	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DDR1 ABCA13 TMPRSS4 DENND2B ARHGAP5 DUOX1 DENND2C	8.11e-06	200	160	7	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CDH26 TMPRSS4 DUOX2 SLC44A4 HYDIN MSLN DUOXA2	8.11e-06	200	160	7	da12821e8a0657869ca0f75d351cce2d7605a505
ToppCell	BAL-Severe-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DDR1 ABCA13 TMPRSS4 SLC44A4 DUOX1 DNAH12 MSLN	8.11e-06	200	160	7	0cc7ff7b6a4eb05d2370ec2f3b9dbfe8cb0699de
ToppCell	BAL-Severe-Epithelial-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DDR1 ABCA13 TMPRSS4 SLC44A4 DUOX1 DNAH12 MSLN	8.11e-06	200	160	7	b9cede2e0939c6b60ce1aa16d7efaaae79354580
ToppCell	BAL-Severe-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DDR1 ABCA13 TMPRSS4 SLC44A4 DUOX1 DNAH12 MSLN	8.11e-06	200	160	7	b762bf6f432eac05a476f6e2ab4da27dd13a2317
ToppCell	BAL-Severe-Epithelial-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DDR1 ABCA13 TMPRSS4 SLC44A4 DUOX1 DNAH12 MSLN	8.11e-06	200	160	7	4c63204e0d868dd4c11c1604a238624a3ad54485
ToppCell	Biopsy_Control_(H.)-Immune-Monocytes\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	VMP1 GPBAR1 FLT3 CEBPD CFP SLC2A3 NOTCH2	8.11e-06	200	160	7	c58a5dc0a0d74a21ca15ee8b7a0197de32afa045
ToppCell	Severe_COVID-19-Epithelial\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	DDR1 ABCA13 TMPRSS4 SLC44A4 DUOX1 DNAH12 MSLN	8.11e-06	200	160	7	49910efb6d888c208cd50530b03af19f87070630
ToppCell	LPS_IL1RA_TNF-Epithelial_airway\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CDH26 TMPRSS4 DUOX2 SLC44A4 HYDIN MSLN DUOXA2	8.11e-06	200	160	7	72c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P1-Tnr\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SERPINE3 E2F8 ADGRF3 SLC51A SPOCD1	1.39e-05	85	160	5	159b3ac93490c3e4918ea61f8ede7add9e63ca40
ToppCell	severe_influenza-CD4+_T_naive\|World / disease group, cell group and cell class (v2)	HSPG2 CLEC18B C12orf56 PIK3IP1 SALL2 CD40LG	2.31e-05	158	160	6	8ab3d8a9b7a1daa890d76dde1d6182af40b70021
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX2 SLC44A4 HPS3 PIK3IP1 ADGRF3 DUOXA2	2.66e-05	162	160	6	3a1cbfed5a063131d49e3c1584f62b12660ecb36
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX2 SLC44A4 HPS3 PIK3IP1 ADGRF3 DUOXA2	2.66e-05	162	160	6	04b3c38bb27fa369a9ac5b60883f8b058abc5180
ToppCell	15-Airway-Mesenchymal-Airway_Smooth_Muscle\|Airway / Age, Tissue, Lineage and Cell class	MAG MYLK ITGA10 CCN6 MTCL1 NPAS4	2.95e-05	165	160	6	531804467601e1ee1f771cffa21501f6d464ae10
ToppCell	10x5'-GI_small-bowel-Myeloid_Mac-Macrophage\|GI_small-bowel / Manually curated celltypes from each tissue	OTOA GPBAR1 HTRA4 OR6N1 CD163L1 SPOCD1	3.27e-05	168	160	6	d5b746d6083c2c8155a0ea345ea368bf6617d5ca
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA13 ASPG TMPRSS4 SLC44A4 SLC16A3 MSLN	3.61e-05	171	160	6	25c1979e972c959e1ce4c57804f976f53a247ad7
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Goblet\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA13 ASPG TMPRSS4 SLC44A4 SLC16A3 MSLN	3.61e-05	171	160	6	fe27bf581c75ef33c2848878e51ed16b275a4c8e
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-DC2\|bone_marrow / Manually curated celltypes from each tissue	FLT3 CDX2 CEBPD CFP ARHGEF10L MSLN	3.73e-05	172	160	6	64928cea7e5b60e4bc4af016454b0173ebcc07c7
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	JMJD4 C15orf39 PTPN4 DUOX1 CD40LG TP73	4.10e-05	175	160	6	a3f8c54c77bce9b035a4835945ab341909be4946
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SERPINE3 CEBPD ITGA10 SERPINE2 PAPPA CDON	4.37e-05	177	160	6	bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell	wk_15-18-Hematologic-Myeloid-aDC_1\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FLT3 CFP FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	4.37e-05	177	160	6	ccf5dc54780d6039a4d062dee88440c011ddc0a3
ToppCell	droplet-Spleen-nan-24m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEBPD DHRS3 ARHGEF10L NDRG1 SLC16A3 DNA2	4.37e-05	177	160	6	5f20a1a875d6f85ec07b097e6afdb07c2f8f88ff
ToppCell	droplet-Spleen-SPLEEN-30m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEBPD E2F8 ARHGEF10L NDRG1 SLC16A3 DNA2	4.51e-05	178	160	6	be8af4d85b8835a85a168639c37857dcaa6b00bf
ToppCell	5'-Adult-Appendix-Epithelial-Tuft-related-Microfold_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DRGX DUOX2 CFP DENND2B SERPINE2 DUOXA2	4.66e-05	179	160	6	7aa4137f672dadb3be92009cde6e0ea60a15372d
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DDR1 CDH26 SLC44A4 UNC5A PAM MSLN	5.11e-05	182	160	6	94e70746e35a3062015d4b83ee545f4f84f47420
ToppCell	Epithelial-ciliated_cell\|World / Lineage, Cell type, age group and donor	ABCA13 SPAG8 DNAH12 WDR49 HYDIN TP73	6.11e-05	188	160	6	61a459f3fe57e5728efc72637ff2edc2d343492b
ToppCell	COPD-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	VMP1 PGS1 CEBPD CFP SLC2A3 NDRG1	6.29e-05	189	160	6	6294691231c7d38707323cf31578a107d3b2c622
ToppCell	IPF-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	VMP1 PGS1 CEBPD CFP SLC2A3 NDRG1	6.29e-05	189	160	6	ad7bb3a7de8e48c145e4382f90d30bb2159c2b76
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	ABCA13 SPAG8 SLC44A4 DNAH12 WDR49 HYDIN	6.29e-05	189	160	6	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CEBPD ABCA13 DRGX SLC44A4 UNC5CL HYDIN	6.29e-05	189	160	6	bd91bdfe35294e60d980259b70fe9e60dca2743f
ToppCell	IPF-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	VMP1 PGS1 CEBPD CFP SLC2A3 NDRG1	6.48e-05	190	160	6	ffa890138394f579fee53fcfac6c121bf86adc26
ToppCell	IPF-Myeloid-cMonocyte\|IPF / Disease state, Lineage and Cell class	VMP1 PGS1 CEBPD CFP SLC2A3 NDRG1	6.48e-05	190	160	6	a099f51f2b7618b6712af38eedd5ee64d8663a4a
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	TMPRSS4 SPAG8 SLC44A4 DNAH12 WDR49 HYDIN	6.67e-05	191	160	6	8a5a2188b13ef4bbfd626a42565566708a751c1b
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)\|356C / Donor, Lineage, Cell class and subclass (all cells)	TMPRSS4 SPAG8 SLC44A4 DNAH12 WDR49 HYDIN	6.67e-05	191	160	6	e314dd8f1a841cab847ae3703bedfe1bc623ac61
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 FLT3 PIK3IP1 SERPINE2 PER3 ORAI3	6.67e-05	191	160	6	4187f31ec399b4c7c3608e94e3c32b7a54b1c3d4
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA13 SPAG8 SLC44A4 DNAH12 WDR49 HYDIN	6.67e-05	191	160	6	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA13 SPAG8 SLC44A4 DNAH12 WDR49 HYDIN	6.67e-05	191	160	6	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	droplet-Marrow-BM-1m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 FLT3 PIK3IP1 SERPINE2 PER3 ORAI3	6.67e-05	191	160	6	8e8bc200524a44ebe132f823ab7c15dac65d4952
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ABCA13 SLC44A4 DNAH12 SLC23A1 HYDIN TP73	6.67e-05	191	160	6	e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 TMPRSS4 DUOX2 SLC44A4 MSLN DUOXA2	6.67e-05	191	160	6	529068029fb461df766135576dd0d8b5980f9bc0
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA13 SPAG8 SLC44A4 DNAH12 WDR49 HYDIN	6.67e-05	191	160	6	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	NS-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HSPG2 TMPRSS4 DUOX2 SLC44A4 MSLN DUOXA2	7.48e-05	195	160	6	b0d782eeee30c797b4da9b3be29b864983fd9e71
ToppCell	NS-moderate-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DHRS3 ABCA13 TMPRSS4 DUOX2 PAM MSLN	7.69e-05	196	160	6	47930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Fibcd1-Excitatory_Neuron.Slc17a7.Fibcd1-Fos_(CA1_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GHSR SPOCD1 NPAS4 MSLN	7.79e-05	63	160	4	22ab24281a42b60e79a6d35e25f42e7f20cb04b9
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	VMP1 CEBPD CFP UNC5A WDR49 NOTCH2	8.14e-05	198	160	6	a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCell	LPS_only-Epithelial_airway-airway_epithelial\|LPS_only / Treatment groups by lineage, cell group, cell type	CDH26 TMPRSS4 DUOX2 HYDIN MSLN DUOXA2	8.14e-05	198	160	6	e035380578c01b0243bfef29ca9b50cc17cce771
ToppCell	LPS_only-Epithelial_airway\|LPS_only / Treatment groups by lineage, cell group, cell type	CDH26 TMPRSS4 DUOX2 HYDIN MSLN DUOXA2	8.14e-05	198	160	6	ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CDH26 ABCA13 TMPRSS4 DUOX1 WDR49 TP73	8.14e-05	198	160	6	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DDR1 ABCA13 TMPRSS4 SLC44A4 DNAH12 HYDIN	8.14e-05	198	160	6	d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCell	BAL-Mild-Epithelial-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DDR1 ABCA13 SLC44A4 DUOX1 DNAH12 HYDIN	8.36e-05	199	160	6	1ee4010d8557564e25e8ee00b914c2dfd9037838
ToppCell	BAL-Mild-Epithelial-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	DDR1 ABCA13 SLC44A4 DUOX1 DNAH12 HYDIN	8.36e-05	199	160	6	1df69c0cb5f759f6a2152521842506a75bb95cae
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DDR1 ASPG TMPRSS4 SLC44A4 SLC51A MSLN	8.36e-05	199	160	6	70c0b9cff195d3d24e98443a729e211cac20c90f
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Airway-Club\|LPS_only / Treatment groups by lineage, cell group, cell type	CDH26 TMPRSS4 DUOX2 NDRG1 MSLN DUOXA2	8.36e-05	199	160	6	165ac94b2d56072ad43358b5127d77555221e2d8
ToppCell	Mild-Epithelial-Epithelial-\|Mild / Condition, Lineage, Cell class and cell subclass	DDR1 ABCA13 SLC44A4 DUOX1 DNAH12 HYDIN	8.36e-05	199	160	6	81115bbd2c10bfdd38376d2075f03a59c31870d2
ToppCell	3'_v3-Lung-Myeloid_Monocytic\|Lung / Manually curated celltypes from each tissue	FLT3 CEBPD C15orf39 CFP SLC2A3 NDRG1	8.36e-05	199	160	6	3e14f9a62d6414add8d5f681be184b4625001838
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 SPAG8 DNAH12 WDR49 HYDIN TP73	8.36e-05	199	160	6	2498237b9e895ca4826a3378d9d40989968df72b
ToppCell	3'_v3-Lung-Myeloid_Monocytic-Classical_monocytes\|Lung / Manually curated celltypes from each tissue	FLT3 CEBPD C15orf39 CFP SLC2A3 NDRG1	8.36e-05	199	160	6	bfd0d171ea6bb7abd5cdfeac22608cc190aaa2be
ToppCell	BAL-Mild-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DDR1 ABCA13 SLC44A4 DUOX1 DNAH12 HYDIN	8.36e-05	199	160	6	74087b4b5e567310fc4ac58fb267ff651a180680
ToppCell	BAL-Mild-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	DDR1 ABCA13 SLC44A4 DUOX1 DNAH12 HYDIN	8.36e-05	199	160	6	00b5ce099c50a5e1786ce2b3a06ee0931a8205a4
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 SPAG8 DNAH12 WDR49 HYDIN TP73	8.36e-05	199	160	6	542ec45c931b40738df1f3777b00c83be33a514a
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DDX56 SRCAP SLC4A2 AHRR NDRG1 SPOCD1	8.36e-05	199	160	6	85bb28369e0568b7b3bda095722102fc793f60ef
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DDR1 ABCA13 TMPRSS4 SLC44A4 SLC51A DUOXA2	8.36e-05	199	160	6	3c3133d0aa65338a576634def13e7f0f5c573a10
ToppCell	Mild-Epithelial\|Mild / Condition, Lineage, Cell class and cell subclass	DDR1 ABCA13 SLC44A4 DUOX1 DNAH12 HYDIN	8.36e-05	199	160	6	ec5fff80e2a8a94fbaf1fdcc6d45c8d7c6252e18
ToppCell	Mild-Epithelial-Epithelial\|Mild / Condition, Lineage, Cell class and cell subclass	DDR1 ABCA13 SLC44A4 DUOX1 DNAH12 HYDIN	8.36e-05	199	160	6	91308b255783ad4029e5575028c18d7550832c51
ToppCell	distal-Epithelial-Ciliated-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ABCA13 SPAG8 SLC44A4 DNAH12 HYDIN TP73	8.36e-05	199	160	6	6ce0df4a6f4d9353919e26ffab97c9ec89911da6
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DDR1 CEBPD DHRS3 TMPRSS4 PAM MSLN	8.36e-05	199	160	6	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	Mild_COVID-19-Epithelial\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	DDR1 ABCA13 SLC44A4 DUOX1 DNAH12 HYDIN	8.36e-05	199	160	6	72689bda7476930887ae007682fcab27f956f050
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DDR1 CDH26 ABCA13 TMPRSS4 SLC44A4 DUOX1	8.60e-05	200	160	6	5f0f67958c9635db53e61f8370a92da6ea3e80fe
ToppCell	control-Epithelial\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DDR1 DHRS3 ABCA13 TMPRSS4 SLC44A4 ARHGAP5	8.60e-05	200	160	6	f95bbb94e51ac28b1995026c599ec3a34e012916
ToppCell	NS-moderate-d_07-13-Epithelial\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DDR1 ABCA13 TMPRSS4 DUOX2 SLC44A4 DUOXA2	8.60e-05	200	160	6	85940b4bf7971b872469dea8b8d7a45bdeb2a909
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Radial_glial\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	DDR1 CEBPD SLC2A3 ARHGAP5 LSAMP NOTCH2	8.60e-05	200	160	6	4477591efada4007bab1f689017e3ac285267d29
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Unfolded_protein_responsible_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	CDX2 TMPRSS4 SLC44A4 NDRG1 SLC16A3 SLC23A1	8.60e-05	200	160	6	12078bc25be67180c0f4b37fef921cdcd1003576
ToppCell	Severe-Epithelial-Epithelial-\|Severe / Condition, Lineage, Cell class and cell subclass	DDR1 ABCA13 TMPRSS4 SLC44A4 DUOX1 MSLN	8.60e-05	200	160	6	8669ce08f93eefb8ac970e30cdc4b1f908023c54
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 SPAG8 DNAH12 WDR49 HYDIN TP73	8.60e-05	200	160	6	926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCell	Severe-Epithelial\|Severe / Condition, Lineage, Cell class and cell subclass	DDR1 ABCA13 TMPRSS4 SLC44A4 DUOX1 MSLN	8.60e-05	200	160	6	6ead9db88568bb829d564a6d8e85f71fd765bac0
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Ciliated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ABCA13 SPAG8 SLC44A4 DNAH12 WDR49 HYDIN	8.60e-05	200	160	6	f1a49bc818054fb0734d3b84725ee6487b034567
ToppCell	Parenchyma_COVID-19-Epithelial-TX-Ciliated\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	ABCA13 SPAG8 SLC44A4 DNAH12 WDR49 HYDIN	8.60e-05	200	160	6	d7ae09189cf0b7e2f7e7fc6b0921975b75aa7d62
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 SPAG8 DNAH12 WDR49 HYDIN TP73	8.60e-05	200	160	6	06ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DDR1 ABCA13 TMPRSS4 ARHGAP5 DUOX1 DENND2C	8.60e-05	200	160	6	ecbe89ff95d046155b984c8c150e0b9e7278f839
Computational	Placenta genes.	MAGEA4 HSPG2 VPS11 MYLK DHRS3 ITGA10 SRCAP DENND2B SLC4A2 SLC16A3 SLC18A3 MARF1 SLC23A2	3.34e-05	463	80	13	MODULE_38
Drug	Progesterone [57-83-0]; Down 200; 12.8uM; HL60; HT_HG-U133A	HSPG2 DHRS3 TICAM1 SLC2A3 ARHGEF10L PIK3IP1 NDRG1 SLC16A3 PML	5.39e-06	186	155	9	2426_DN
Drug	Lisuride (S)(-) [18016-80-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	TICAM1 LRFN3 PIDD1 SKI ARHGEF10L ORAI3 SLC23A2 CDON PML	8.93e-06	198	155	9	5028_DN
Drug	Evoxine [522-11-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A	MYLK TICAM1 PIDD1 SKI RGS12 PER3 CLCN6 NOTCH2 LRRC41	8.93e-06	198	155	9	4704_DN
Drug	Mebeverine hydrochloride [2753-45-9]; Up 200; 8.6uM; MCF7; HT_HG-U133A	MAG ITGA10 SPAG8 RGS12 LMF2 PER3 CLCN6 DCAF4 PML	9.30e-06	199	155	9	6795_UP
Drug	fluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A	C15orf39 SRCAP SLC2A3 SERPINE2 NDRG1 CLCN6 SLC16A4 MTCL1	3.09e-05	178	155	8	5234_UP
Drug	Retinoic acid [302-79-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	MAG DHRS3 SZT2 TICAM1 C15orf39 LMF2 NOTCH2 PML	4.06e-05	185	155	8	6243_UP
Drug	6-deoxy-6-bromoascorbic acid	SLC23A2 SLC23A1	4.60e-05	2	155	2	ctd:C068572
Drug	Prothanon	PAM CCL21	4.60e-05	2	155	2	CID000063031
Drug	Benzethonium chloride [121-54-0]; Down 200; 9uM; HL60; HT_HG-U133A	CABP2 RMND5A ITGA10 JMJD4 CFP SLC2A3 NDRG1 SLC16A3	4.73e-05	189	155	8	2508_DN
Drug	Tolbutamide [64-77-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A	HSPG2 PIDD1 SKI SLC16A3 SLC23A2 PDLIM2 FOXG1 PML	4.91e-05	190	155	8	4362_DN
Drug	thapsigargin; Down 200; 0.1uM; MCF7; HT_HG-U133A	HSPG2 CEBPD TICAM1 RGS12 ARHGEF10L SALL2 SBNO1 SLC23A2	5.09e-05	191	155	8	7100_DN
Drug	Epitiostanol [2363-58-8]; Down 200; 13uM; HL60; HT_HG-U133A	HSPG2 PIDD1 SRCAP SKI WDR91 INTS5 SLC16A4 PAM	6.11e-05	196	155	8	2922_DN
Drug	Carbimazole [22232-54-8]; Down 200; 21.4uM; HL60; HT_HG-U133A	JMJD4 PIDD1 SKIL PIK3IP1 PER3 SLC16A3 NOTCH2 PML	6.11e-05	196	155	8	2437_DN
Drug	Metoclopramide monohydrochloride [7232-21-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A	DHRS3 ITGA10 JMJD4 DENND2B MECR SLC23A2 FOXG1 PML	6.11e-05	196	155	8	2315_DN
Drug	GSK-3beta Inhibitor VIII; Up 200; 10uM; MCF7; HT_HG-U133A	HSPG2 LRFN3 SRCAP WDR91 LMF2 CLCN6 SLC23A2 PML	6.11e-05	196	155	8	7092_UP
Drug	Nomegestrol acetate [58652-20-3]; Up 200; 10.8uM; MCF7; HT_HG-U133A	RMND5A CEBPD RGS12 LMF2 SLC16A4 DCAF4 FOXG1 PML	6.11e-05	196	155	8	5461_UP
Drug	Ethynylestradiol 3-methyl ether [72-33-3]; Up 200; 12.8uM; HL60; HT_HG-U133A	MYLK DENND2B PIK3IP1 LMF2 CD40LG PAPPA SLC23A2 PML	6.33e-05	197	155	8	3008_UP
Drug	Diloxanide furoate [3736-81-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	RMND5A TICAM1 TMPRSS4 SRCAP CLCN6 SLC16A4 CDON PML	6.33e-05	197	155	8	3399_DN
Drug	Methantheline bromide [53-46-3]; Down 200; 9.6uM; HL60; HT_HG-U133A	EPHB6 RMND5A DHRS3 SPAG8 OR1G1 NOTCH2 CDON PML	6.56e-05	198	155	8	6137_DN
Drug	Yohimbine hydrochloride [65-19-0]; Up 200; 10.2uM; MCF7; HT_HG-U133A	CABP2 SZT2 TICAM1 RGS12 PIK3IP1 SLC16A4 CCL21 PML	6.56e-05	198	155	8	6777_UP
Drug	Zoxazolamine [61-80-3]; Up 200; 23.8uM; MCF7; HT_HG-U133A	SZT2 PIDD1 SPAG8 SRCAP SKI PIK3IP1 LMF2 PML	6.56e-05	198	155	8	5390_UP
Drug	Ranitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; MCF7; HT_HG-U133A	HSPG2 ITGA10 PIDD1 SRCAP PIK3IP1 SLC16A3 NOTCH2 PML	6.56e-05	198	155	8	2251_DN
Drug	Folinic acid calcium salt [6035-45-6]; Down 200; 7.8uM; MCF7; HT_HG-U133A	MYLK TICAM1 PIDD1 SRCAP SKI CLCN6 CDON PML	6.80e-05	199	155	8	4725_DN
Drug	rosiglitazone; Down 200; 10uM; HL60; HT_HG-U133A	EPHB6 PEX6 GON4L WDR91 PAM SLC23A2 NOTCH2 PML	7.04e-05	200	155	8	6192_DN
Disease	salivary gland cancer (implicated_via_orthology)	GON4L YY1AP1	2.53e-05	2	149	2	DOID:8850 (implicated_via_orthology)
Disease	Transient hypothyroxinaemia of prematurity	DUOX2 DUOXA2	2.53e-05	2	149	2	C3827793
Disease	X-24431 measurement	SLC23A2 SLC23A1	7.57e-05	3	149	2	EFO_0800882
Disease	carotid artery disease (is_marker_for)	HSPG2 CD40LG PAPPA	1.15e-04	19	149	3	DOID:3407 (is_marker_for)
Disease	phenylketonuria (implicated_via_orthology)	DUOX2 DUOX1	1.51e-04	4	149	2	DOID:9281 (implicated_via_orthology)
Disease	tartronate (hydroxymalonate) measurement	SLC23A2 SLC23A1	1.51e-04	4	149	2	EFO_0800944
Disease	glia-derived nexin measurement	SERPINE2 FAM124B	1.51e-04	4	149	2	EFO_0020403
Disease	Thyroid Dyshormonogenesis 1	DUOX2 DUOXA2	3.75e-04	6	149	2	C1848805
Disease	extraversion measurement	SLC23A2 SLC23A1	3.75e-04	6	149	2	EFO_0007913
Disease	oxalate measurement	MYLK SLC23A2 SLC23A1	5.62e-04	32	149	3	EFO_0010517
Disease	multiple myeloma (is_marker_for)	CD40LG NOTCH2 PML	7.97e-04	36	149	3	DOID:9538 (is_marker_for)
Disease	post-operative acute kidney injury	CDH26 ARHGEF10L	8.91e-04	9	149	2	EFO_0009955
Disease	primary bacterial infectious disease (implicated_via_orthology)	DUOX2 DUOX1	8.91e-04	9	149	2	DOID:0050338 (implicated_via_orthology)
Disease	synaptotagmin-11 measurement	GON4L SERPINE2	8.91e-04	9	149	2	EFO_0802108
Disease	threonate measurement	SLC23A2 SLC23A1	1.11e-03	10	149	2	EFO_0021032
Disease	platelet crit	VMP1 VPS11 PGS1 FLT3 SKI DENND2B SIRPD SBNO1 KCND1 CD40LG PHLPP1 LINC02694 PDLIM2	1.12e-03	952	149	13	EFO_0007985
Disease	Malignant neoplasm of breast	MAGEA4 TFAP2D TICAM1 SPTLC1 CFP SERPINE2 LMF2 NDRG1 PER3 SLC16A3 SBNO1 SPOCD1 NOTCH2 TP73	1.12e-03	1074	149	14	C0006142
Disease	hepatocyte growth factor measurement	RGS12 SERPINE2 NOTCH2	1.44e-03	44	149	3	EFO_0006903
Disease	Gastrointestinal Stromal Sarcoma	C2CD3 IFT52 CDON	1.74e-03	47	149	3	C3179349
Disease	pre-eclampsia (implicated_via_orthology)	CD40LG NOTCH2	1.90e-03	13	149	2	DOID:10591 (implicated_via_orthology)
Disease	hypothyroidism (implicated_via_orthology)	DUOX2 DUOX1	1.90e-03	13	149	2	DOID:1459 (implicated_via_orthology)
Disease	Gastrointestinal Stromal Tumors	C2CD3 IFT52 CDON	2.08e-03	50	149	3	C0238198
Disease	dystonia (is_implicated_in)	VPS11 MECR	2.21e-03	14	149	2	DOID:543 (is_implicated_in)
Disease	ascorbic acid 3-sulfate measurement	SLC23A2 SLC23A1	2.21e-03	14	149	2	EFO_0800173
Disease	congenital hypothyroidism (implicated_via_orthology)	DUOX2 DUOX1	2.21e-03	14	149	2	DOID:0050328 (implicated_via_orthology)
Disease	Saldino-Noonan Syndrome	C2CD3 IFT52	2.21e-03	14	149	2	C0036069
Disease	Glioblastoma Multiforme	EPHB6 NDRG1 NOTCH2 PML	2.46e-03	111	149	4	C1621958
Disease	glycerate measurement	SLC23A2 SLC23A1	2.55e-03	15	149	2	EFO_0021029
Disease	vitamin C measurement	SLC23A2 SLC23A1	2.90e-03	16	149	2	EFO_0600003
Disease	platelet-derived growth factor BB measurement	SERPINE2 LSAMP FAM124B	3.67e-03	61	149	3	EFO_0008264

Protein segments in the cluster

Peptide	Gene	Start	Entry
LATLVPPQASGCTFL	AHRR	686	A9YTQ3
ETPGCATLLPASLFV	DCAF4	251	Q8WV16
AINAFLDCSVVLPPS	SLC4A2	601	P04920
PGFQLSCCIPSTNLA	ADGRF3	351	Q8IZF5
PVNCPLLGFSAVSTS	ARHGEF10L	806	Q9HCE6
QEPSLGCSIPAILFL	CCL21	51	O00585
PAAAPSCASGLLQTL	CDX2	126	Q99626
QAPFIASLCLKSPGR	CD40LG	186	P29965
SAPCVPNGSALLLSN	DDR1	496	Q08345
PRFISPASQVAICLA	GRM2	671	Q14416
DLPSCGVIPFVQSLL	ABCA13	61	Q86UQ4
PSLLVLLVFPSSCLA	PAM	6	P19021
EPLPGQVCSTFTLCL	CEP76	126	Q8TAP6
SVICTGSLTQPLFPC	CD163L1	996	Q9NR16
GSLTQPLFPCLANVS	CD163L1	1001	Q9NR16
AGVAACLPLAQSTPF	DENND2B	126	P78524
LLPSPLAVLTFTLCS	CDC14C	416	A4D256
PCFPTVTSLQDLASG	CAMSAP3	221	Q9P1Y5
LRNSFNTSPGVPCSL	CCDC14	301	Q49A88
NPTDLFCSVPGRLSL	TFAP2D	206	Q7Z6R9
VQLQCLAHGTPPLTF	HSPG2	3316	P98160
SRESSALPLLFPCGN	UROS	131	P10746
LDSPLCTSLGFASPL	MTCL1	1576	Q9Y4B5
TGRLPCPSNTAALLA	PTPN4	136	P29074
LGVNFPLSFPNLCSC	INO80	951	Q9ULG1
PPGLLVAFSACTTVL	ORAI3	91	Q9BRQ5
SISPLSVLSCLFPGL	DUOX1	1156	Q9NRD9
GLVTCSIPDNLPFTL	PCDHGA4	411	Q9Y5G9
ASVPASQCVPFLISL	OTOA	646	Q7RTW8
SPVICGPNRSFLSLK	NOTCH2	2081	Q04721
FPPVLSLACTDTSIN	OR6N1	181	Q8NGY5
PLFALACISAPSTEL	OR11H6	201	Q8NGC7
TLRNSSLGTPCLFPE	KCND1	626	Q9NSA2
QSVLISCAIAGDPFP	MYLK	736	Q15746
PQGASALPTTISFTC	MAGEA4	66	P43358
LCSTQSNPDPILTIF	MAG	346	P20916
LAAAGSPVFLCALSP	SLC16A3	151	O15427
AFCSPNLLPLATVGA	ASPG	196	Q86U10
RSPPAGCFFLSLLLA	GPBAR1	46	Q8TDU6
PPLLLGQFCSNSSSI	FOXD4L4	376	Q8WXT5
PPPLLGQFCSNSSSI	FOXD4L3	376	Q6VB84
GSLPSSTCFLLLPLL	CD300H	161	A0A0K2S4Q6
FSIPTCVLNGELPLR	DDX56	281	Q9NY93
FVGLADTPSCAVLLP	DCAF4L2	146	Q8NA75
DTPSCAVLLPASLFI	DCAF4L2	151	Q8NA75
PPGLLIAFSACTTVL	ORAI1	116	Q96D31
TDGLPQCAPLTVLDF	DUOX2	576	Q9NRD8
AAALAASVPCGLSVP	FOXG1	381	P55316
LPCPFLGATASSAIS	PER3	866	P56645
PPVQSSLCCLQFTAL	OR3A4P	316	P47883
SSLPCLTLIGSPNFG	PGS1	476	Q32NB8
ALVPATLAFNLGCDP	PEX6	271	Q13608
LQCPALLVVGDSSPA	NDRG1	251	Q92597
NCTIPLIFVLSPGAD	DNAH12	2491	Q6ZR08
FPSGDCPSAIALLAI	KCNJ13	126	O60928
TSVPSVPLGSRQCFL	PDZD3	456	Q86UT5
CQPTPGLETLNLTTF	KRTAP3-2	71	Q9BYR7
CQPTPGLETLNLTTF	KRTAP3-3	71	Q9BYR6
PLFLLASVTLPSICS	SERPINE2	6	P07093
LSPRQLLGFPCAEVS	MSLN	61	Q13421
AICDITFPPGLSQLV	LRRC8E	446	Q6NSJ5
TQSLPLSVLCPGAGL	LRFN3	36	Q9BTN0
TLPATGSDPVLCFTQ	CFP	21	P27918
ITLPLSAFTNPTCEI	PIK3IP1	216	Q96FE7
FLLDTSLEPPLCGQT	PAPPA	316	Q13219
PPLACALQAFSLGQR	PELP1	596	Q8IZL8
INPLLSLSCTDPFTN	OR1G1	181	P47890
ACFSQPPTAAQLLRA	SLC51A	31	Q86UW1
AQGETPCLLSPALFQ	SCYL3	321	Q8IZE3
PSLVSFLTGLGCPNC	TP73	491	O15350
CSSTNPLFTAALGAP	NPAS4	356	Q8IUM7
PISEVILASQLPFCA	OR6N2	156	Q8NGY6
QPNPLFSCLCVSGAI	CCN6	136	O95389
GTSCETILLNSPGPF	FLT3	521	P36888
VFALASISSVPLCPL	DUOXA2	221	Q1HG44
CSSQLSAPTFLRQGP	CEFIP	1351	Q711Q0
GISVPSGLFVPSLLC	CLCN6	481	P51797
ALPTCALGTTPVFDL	HTRA4	51	P83105
LQTSQPPFCLPASSL	FAM124B	386	Q9H5Z6
FSPSVLDLGPLLLCA	HYDIN	1826	Q4G0P3
TGSVCFPLNRPILAF	IFT52	186	Q9Y366
STSLPPLVEGQLRCF	C2CD3	26	Q4AC94
ATLFPSGYLIPLTQC	E2F8	631	A0AVK6
PGSLLPAQVAACAQT	CEBPD	131	P49716
QLFPAPLLAGVTATC	GHSR	36	Q92847
AFSPGLPPQSCSLNL	FITM2	241	Q8N6M3
VRGFLLPNLPCVFSS	JMJD4	91	Q9H9V9
FVTLSCNASGLPVPV	CDON	421	Q4KMG0
PLVICSGISNQPLEF	DDX11L8	661	A8MPP1
TTLLVNPTSFPCPLN	GON4L	1181	Q3T8J9
VCSPTPFLIGILSCS	DENND2C	736	Q68D51
PSCLPGTLLNTATYA	DRGX	151	A6NNA5
CLLPSSQARQSPLGS	MARF1	936	Q9Y4F3
LPLVFLTGLCSPFNL	ITGA10	11	O75578
QRPALLICTAAAGPT	CDH26	681	Q8IXH8
ACPFVPLLSVQTLDS	DENND4B	1191	O75064
TILPAILQSAALPFC	SLC2A3	191	P11169
SLQQELCPSFLLPSA	SLC44A4	161	Q53GD3
IPLQSAATLGVNPCT	MECR	156	Q9BV79
ISNPVSGLFLLCSPT	ESRG	81	Q1W209
QISQPICLGPLFFSR	DNA2	766	P51530
NIAALSLVPGCSPSI	SALL2	976	Q9Y467
PANCVSPLVNLLSTS	SBNO1	1351	A3KN83
LNSLVGPACIFLRPS	CABP2	51	Q9NPB3
LLDCPGVSATTVLPF	DHRS3	206	O75911
PLLCLSQSGPPSFLQ	PIDD1	516	Q9HB75
VQIFLALSLPFCGPN	OR4C16	156	Q8NGL9
LLSPQQTISIPGCAA	OR10J4	86	P0C629
CLRQTLPLSFVFGPE	SZT2	1736	Q5T011
GALTTCNIPLAFLEP	SLC18A3	296	Q16572
PLSVSFSAGCVALPA	RMND5A	281	Q9H871
NCSFSTPVPLSLGKL	SPAG8	436	Q99932
LPFNAPSCGLITLTD	SKIL	211	P12757
ICGPSFDIASIIPFL	HPS3	866	Q969F9
FVQALLAPCSLRSSP	LMF2	651	Q9BU23
QPAPLLCSVLKASGS	LRRC41	601	Q15345
CLLPTGLPVRSVDFN	LSAMP	21	Q13449
TFTTVPCLCLLGPNL	PIGF	121	Q07326
PLAAVPSNLTCTLFR	PTCHD1	811	Q96NR3
PFSSLQCFASLQPLV	PML	771	P29590
PPLLLGQFCSNSSSI	FOXD4L5	376	Q5VV16
PPPLLGQFCSNSSSI	FOXD4L6	376	Q3SYB3
SQALLTPVALDFPCL	EPHB6	936	O15197
CGDPFSVDLILSPFL	ARHGAP5	786	Q13017
ASLLAICPFPSEALS	INTS5	626	Q6P9B9
FVPLTSICFPDSLLQ	PRR12	926	Q9ULL5
GLNSTVAPACSPVLV	SRCAP	1536	Q6ZRS2
CTGFFLSLLPKSTPN	MRPL47	31	Q9HD33
LFPTILISQLPFCGS	OR6J1	156	Q8NGC5
ISRSFQSLACSPGLP	PDLIM2	151	Q96JY6
ILPFSAPSCGLITKT	SKI	166	P12755
NGALPLNLTCTVSPS	SLC6A7	176	Q99884
CFSASLPPLLAAAAI	SPTLC1	336	O15269
FLQSCPPIITFVASI	C12orf56	521	Q8IXR9
LAQARAALCGTPTPS	CLEC18A	81	A5D8T8
LAQARAALCGIPTPS	CLEC18B	81	Q6UXF7
LAQARAALCGIPTPS	CLEC18C	81	Q8NCF0
QQPLSVTCFSLALPS	C15orf39	696	Q6ZRI6
CQSLLSDPLGVTFPT	LINC02694	161	Q8NAA6
GSAASKFLCLPPGIT	VPS11	36	Q9H270
VLAGTACLFTPLALP	TMEM11	86	P17152
NGCIPLVDPFASESL	TMEM235	66	A6NFC5
GCLEFPASSLPVLQF	RGS12	371	O14924
CGITNLLAPLATTFP	SLC16A4	376	O15374
SLPDPVLGALFCTLF	SLC23A2	481	Q9UGH3
CLAFILDNTVPGSPE	SLC23A1	506	Q9UHI7
RTLQSNLGCLPPSSA	TICAM1	156	Q8IUC6
PLVCATGLLGSAPFL	SPNS1	356	Q9H2V7
ALPTVIRSAGCIPSN	SPOCD1	896	Q6ZMY3
ILCAAFLPPQTLVTG	WDR49	286	Q8IV35
VFCSPLVPGQSHLQL	UNC5CL	251	Q8IV45
LQFPLTFSGTVRPIC	TMPRSS4	296	Q9NRS4
LACSLFVQVGTPLSP	SERPINE3	111	A8MV23
SIILSCSVPNTLPNG	SIRPD	46	Q9H106
CNDGLLESFPAVLPS	USF3	836	Q68DE3
STLCLPSVGAARPQV	RHPN2P1	551	A8MT19
CLRVFGTLLQPVTPS	MARS2	516	Q96GW9
PLAGCQTLLSPIVSC	UNC5A	491	Q6ZN44
LALLRPSCAFGPNTI	PRSS48	286	Q7RTY5
FPCPLNQPLVASSVS	YY1AP1	646	Q9H869
PPVLLQGSCSASAVA	ZNF621	366	Q6ZSS3
FPLAVCSIPTLAELN	PHLPP1	706	O60346
QASPGASSFLTCPEL	nan	51	Q6AWC8
PRILSLACSPNGASF	WDR91	496	A4D1P6
LACASIPNPLFDLAG	VMP1	261	Q96GC9
TAALIIACFPTISPF	VN1R2	351	Q8NFZ6