Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hypotaurine monooxygenase activity	FMO4 FMO5	7.96e-05	5	57	2	GO:0047822
GeneOntologyMolecularFunction	N,N-dimethylaniline monooxygenase activity	FMO4 FMO5	1.19e-04	6	57	2	GO:0004499
HumanPheno	Abnormality of neutrophil physiology	CYBC1 LYST PMM2	1.37e-05	17	15	3	HP:0011990
Domain	FMO-like	FMO4 FMO5	8.47e-05	5	55	2	PF00743
Domain	Flavin_mOase	FMO4 FMO5	8.47e-05	5	55	2	IPR000960
Domain	Flavin_mOase-like	FMO4 FMO5	8.47e-05	5	55	2	IPR020946
Domain	DiMe-aniline_mOase	FMO4 FMO5	8.47e-05	5	55	2	IPR012143
Domain	ABC_A	ABCA5 ABCA12	5.51e-04	12	55	2	IPR026082
Domain	Homeodomain-like	CASP8AP2 FMO4 FMO5 TERB1 TIGD4	2.89e-03	332	55	5	IPR009057
Domain	GDS_CDC24_CS	ABR MCF2	5.88e-03	39	55	2	IPR001331
Pathway	WP_CATALYTIC_CYCLE_OF_MAMMALIAN_FLAVINCONTAINING_MONOOXYGENASES_FMOS	FMO4 FMO5	8.21e-05	5	41	2	M39449
Pubmed	Urinary evaluation of the balance between the soluble interferon-gamma receptor (IFN-gammaR1) and the interleukin-4 receptor (IL-4Ralpha) in children with vesicoureteral reflux.	IFNGR1 IL4R	2.64e-06	2	57	2	19739012
Pubmed	Urinary evaluation of the balance between soluble interferon-gamma receptor (IFN-gammaR1) and interleukin-4 receptor (IL-4Ralpha).	IFNGR1 IL4R	2.64e-06	2	57	2	18809513
Pubmed	Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse.	IFNGR1 IL4R	7.91e-06	3	57	2	19349465
Pubmed	Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450.	FMO4 FMO5	7.91e-06	3	57	2	11551524
Pubmed	Tumor-induced myeloid-derived suppressor cell function is independent of IFN-γ and IL-4Rα.	IFNGR1 IL4R	7.91e-06	3	57	2	22673957
Pubmed	Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells.	IFNGR1 IL4R	1.58e-05	4	57	2	12454749
Pubmed	Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation.	IFNGR1 IL4R	1.58e-05	4	57	2	23976880
Pubmed	The molecular biology of the flavin-containing monooxygenases of man.	FMO4 FMO5	1.58e-05	4	57	2	7720101
Pubmed	Variant mapping and mutation discovery in inbred mice using next-generation sequencing.	ABCA12 ADAR	1.58e-05	4	57	2	26552429
Pubmed	The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression.	FMO4 FMO5	2.63e-05	5	57	2	8128486
Pubmed	Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.	FMO4 FMO5	2.63e-05	5	57	2	32156684
Pubmed	Infection with Syphacia obvelata (pinworm) induces protective Th2 immune responses and influences ovalbumin-induced allergic reactions.	IFNGR1 IL4R	2.63e-05	5	57	2	16988272
Pubmed	A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities.	FMO4 FMO5	2.63e-05	5	57	2	8311461
Pubmed	Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node.	IFNGR1 IL4R	2.63e-05	5	57	2	20418876
Pubmed	Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.	FMO4 FMO5	3.94e-05	6	57	2	12527699
Pubmed	Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors.	IFNGR1 IL4R	3.94e-05	6	57	2	12133952
Pubmed	T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17.	IFNGR1 IL4R	5.51e-05	7	57	2	16880257
Pubmed	Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis.	IFNGR1 IL4R	5.51e-05	7	57	2	12020266
Pubmed	IL-10 promoter and IL4-Ralpha gene SNPs are associated with immediate beta-lactam allergy in atopic women.	IFNGR1 IL4R	9.43e-05	9	57	2	16867043
Pubmed	The human ATP-binding cassette (ABC) transporter superfamily.	ABCA5 ABCA12	1.18e-04	10	57	2	11435397
Pubmed	IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.	RIN3 FAM13A	1.18e-04	10	57	2	25101718
Pubmed	Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.	RIN3 FAM13A	1.44e-04	11	57	2	24621683
Pubmed	Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes.	IFNGR1 IL4R	2.37e-04	14	57	2	17152005
Pubmed	Dual Requirement of Cytokine and Activation Receptor Triggering for Cytotoxic Control of Murine Cytomegalovirus by NK Cells.	IFNGR1 LYST	2.37e-04	14	57	2	26720279
Pubmed	Assessment of community efforts to advance network-based prediction of protein-protein interactions.	TTC23 CYBC1 KSR2 RETREG1 TCEANC ZBTB14	5.72e-04	630	57	6	36949045
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCA5 ABCA12	5.97e-04	22	57	2	8894702
Pubmed	Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.	LRRC8C ZBTB14	6.53e-04	23	57	2	31748650
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	FLII TTC23 GVINP1 POLA1	1.22e-03	284	57	4	29459677
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	FLII UBR4 ADAR	1.29e-03	130	57	3	35545047
Pubmed	KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.	SLF1 UBR4	1.35e-03	33	57	2	25582440
Cytoband	6q15	CASP8AP2 GJB7	6.88e-04	31	57	2	6q15
Cytoband	Ensembl 112 genes in cytogenetic band chr6q15	CASP8AP2 GJB7	1.86e-03	51	57	2	chr6q15
GeneFamily	ATP binding cassette subfamily A	ABCA5 ABCA12	4.27e-04	14	40	2	805
Coexpression	GSE22886_IGM_MEMORY_BCELL_VS_BLOOD_PLASMA_CELL_UP	FMO5 SACS ABCA12 RETREG1 GSAP LYST	4.08e-06	198	56	6	M4451
Coexpression	GSE22886_IGM_MEMORY_BCELL_VS_BM_PLASMA_CELL_UP	CASP8AP2 SACS MTF2 GSAP LYST QRSL1	4.33e-06	200	56	6	M4456
Coexpression	ONKEN_UVEAL_MELANOMA_UP	IFNGR1 KDELR3 CASP8AP2 RIN3 ABR SACS POLA1 RETREG1 PMM2	4.18e-05	790	56	9	M12490
Coexpression	PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP	CASP8AP2 SLF1 ABCA5 MTF2 POLA1	6.08e-05	195	56	5	M13736
Coexpression	GSE12366_GC_VS_NAIVE_BCELL_DN	IFNGR1 RIN3 GVINP1 GSAP LYST	6.08e-05	195	56	5	M3170
Coexpression	GSE29618_BCELL_VS_PDC_UP	GVINP1 GSAP LYST IL4R QRSL1	6.23e-05	196	56	5	M4940
Coexpression	GSE19825_IL2RALOW_VS_IL2RAHIGH_DAY3_EFF_CD8_TCELL_UP	IFNGR1 FMO5 EMB CYBC1 IL4R	6.85e-05	200	56	5	M4301
ToppCell	distal-2-Hematologic-Myeloid_Dendritic_Type_2\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADORA3 RIN3 SACS ATP13A5 ZBTB14	4.94e-06	194	57	5	6881cfe12837a32e598535a564e4c31d4846167b
ToppCell	distal-Hematologic-Myeloid_Dendritic_Type_2-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADORA3 RIN3 SACS ATP13A5 ZBTB14	5.07e-06	195	57	5	7606b8b40e704bb5447ac57ccf8698794e9c7890
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRRC8C PTPN4 SLF1 EMB LYST	5.32e-06	197	57	5	1ca06d6d288cb58a6e8062ebc01831e58ee5be4b
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Il33_(Il33)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KDELR3 TMEM45A ENPP3 TIGD4	1.08e-05	107	57	4	d446ffbe93cd49669f1cf91411aae07cc15d9e2a
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Il33_(Il33)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KDELR3 TMEM45A ENPP3 TIGD4	1.08e-05	107	57	4	5c9e745d0b08a4aa1f3a93f9cc094fac57061a30
Disease	immunoglobulin isotype switching measurement	RIN3 EMB UBR4	8.11e-05	44	56	3	EFO_0010128
Disease	open-angle glaucoma	AFAP1 FAM13A TCIM PMM2	4.80e-04	191	56	4	EFO_0004190
Disease	interleukin-6 measurement	KSR2 SCN7A ADAR	1.27e-03	112	56	3	EFO_0004810
Disease	posterior urethral valve	RIN3 FMO5	1.39e-03	29	56	2	MONDO_0019640
Disease	Autoinflammatory disorder	POLA1 ADAR	2.02e-03	35	56	2	C3860213
Disease	Colorectal Carcinoma	ADORA3 ABCA5 SACS ABCA12 ADAM29 PMM2	2.10e-03	702	56	6	C0009402
Disease	breast cancer, ovarian carcinoma	RIN3 ADAM29	2.26e-03	37	56	2	EFO_0001075, MONDO_0007254
Disease	hereditary spastic paraplegia (implicated_via_orthology)	CAPN9 ATP13A5	3.04e-03	43	56	2	DOID:2476 (implicated_via_orthology)
Disease	response to bronchodilator, FEV/FEC ratio	RIN3 AFAP1 FAM13A EMB KSR2 LYST	3.23e-03	766	56	6	EFO_0004713, GO_0097366
Disease	monokine induced by gamma interferon measurement	RIN3 ERCC6L2	4.41e-03	52	56	2	EFO_0008236
Disease	3-hydroxypropylmercapturic acid measurement	EMB KSR2 ERCC6L2 PLA2G4E	4.49e-03	352	56	4	EFO_0007014

Protein segments in the cluster

Peptide	Gene	Start	Entry
VFLFTDVLLCAKLKK	ABR	321	Q12979
TLLLKNYLIKCRTKK	ABCA5	16	Q8WWZ7
KKKKKFCYLCILLLI	ADAM29	671	Q9UKF5
SVLFSITLKDKKLCY	CATSPERG	821	Q6ZRH7
YAQKRLKKKKIFCIS	ATP13A5	456	Q4VNC0
IKKFKETYLLILKAC	ADORA3	286	P0DMS8
LYCLTKTYQLIHKKI	ABCA12	2256	Q86UK0
KLLCVIKDTKLLCYK	AFAP1	171	Q8N556
INFCKKSSIYKTKCI	GVINP1	576	Q7Z2Y8
YLFAKLKKILVCDSK	CASP8AP2	1141	Q9UKL3
IKKINILKQSCFIIF	MTF2	66	Q9Y483
LKIVKISFKCKQFFI	PTPN4	256	P29074
SAICKLSKLKKLYLN	FLII	286	Q13045
QKKCYGKIKASVLLI	MYO1A	736	Q9UBC5
SKLVKYFSRQLSCKK	KSR2	61	Q6VAB6
YLYVTKVLKGKKLSL	KDELR3	196	O43731
LKYIQFKTTVCSITK	FMO4	101	P31512
LKSLCTKKIFLYKQV	FMO4	341	P31512
CFLSTIKSIEKKVLY	HEATR6	426	Q6AI08
CLLKYLCQFLTKVAK	FAM13A	166	O94988
SLLLLKKKKYAALVV	POLA1	1046	P09884
SKKIFLSKLIVCFLS	GPR160	236	Q9UJ42
KLSYVKTCQEKFKKL	OCIAD1	91	Q9NX40
LTVLYDLTKLCFRKK	PLA2G4E	151	Q3MJ16
LKKSRSILKCIQFYA	GSAP	226	A4D1B5
AVCLLCYVSITKIKK	IL4R	246	P24394
EIYTFLSKKCLKKLS	C5orf60	106	A6NFR6
VSKKNIFLLFKKLCS	ADAR	1156	P55265
FIAIKNKYASSKLLK	CCNB2	361	O95067
KCLSLIKKTKFLNAY	QRSL1	26	Q9H0R6
NTLKKYKIACIVLLA	ENPP3	16	O14638
LLKYIRFKTTVCSVK	FMO5	101	P49326
GKVVLKTFSLYKKLL	CYBC1	76	Q9BQA9
IKQKCIVGFYILKTL	LYST	1866	Q99698
TKYQLLLKELLKYSK	MCF2	636	P10911
FIKCCLQKYLKKPQV	GJB7	206	Q6PEY0
ATILLCEKYTQKKKK	EMB	276	Q6PCB8
QVCSLKTYKRKSVKF	ERCC6L2	1336	Q5T890
IKFKKLSLISCKNII	CAPN9	556	O14815
IFLKYLKKTGSKNLC	SACS	2011	Q9NZJ4
ICFYIKKINPLKEKS	IFNGR1	266	P15260
EKKISILLKTCKLIY	RIN3	756	Q8TB24
LCLVSRYSQKLKKKI	PGBD3	431	Q8N328
NYCLSYIAKIKLPKK	PMM2	101	O15305
KIYSKIKSVLLKLDF	RETREG1	241	Q9H6L5
ACSTYFKKLFKKLEV	ZBTB14	56	O43829
TLYSKNIKKYKTCIR	TCEANC	211	Q8N8B7
IQYLKSVQLFSKKFK	RFX8	246	Q6ZV50
LKIKYRHCLIKKFLS	TIGD4	326	Q8IY51
LLLKLDCTFIKSEKY	SLF1	26	Q9BQI6
YGKLCKKSTLSLYQK	ZNF510	661	Q9Y2H8
KKGINYVLLKILCKT	SCN7A	756	Q01118
TKIFSKAKYCQLIKE	ZBED9	241	Q6R2W3
TLKIIILKRKYFQQC	SLC9C2	656	Q5TAH2
RKKLKKCLQIQTLLY	TTC23	376	Q5W5X9
KLFQFLKLRKYSIKV	TCIM	91	Q9NR00
TVLLKLFSYCVKVKV	UBR4	4506	Q5T4S7
ILKYICKKQKRTCYL	TMEM45A	26	Q9NWC5
YKSELRKSLICNKKI	TERB1	631	Q8NA31
YFCKKLKTLKIGKNS	LRRC8C	726	Q8TDW0