Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ADP binding	PRPS2 MYH9 PGK1 PRPS1	1.68e-05	48	64	4	GO:0043531
GeneOntologyMolecularFunction	ribose phosphate diphosphokinase activity	PRPS2 PRPS1	1.01e-04	5	64	2	GO:0004749
GeneOntologyMolecularFunction	diphosphotransferase activity	PRPS2 PRPS1	1.50e-04	6	64	2	GO:0016778
GeneOntologyCellularComponent	ribose phosphate diphosphokinase complex	PRPS2 PRPS1	9.17e-05	5	64	2	GO:0002189
HumanPheno	Underdeveloped nasal alae	UBR1 ORC4 DGCR6 RECQL KDM6A PRPS1	2.03e-05	104	29	6	HP:0000430
Domain	DGCR6	DGCR6 DGCR6L	1.12e-05	2	63	2	PF07324
Domain	Gonadal	DGCR6 DGCR6L	1.12e-05	2	63	2	IPR010849
Domain	PRPP_SYNTHASE	PRPS2 PRPS1	3.35e-05	3	63	2	PS00114
Domain	PRib_PP_synth_CS	PRPS2 PRPS1	3.35e-05	3	63	2	IPR000842
Domain	Rib-P_diPkinase	PRPS2 PRPS1	1.11e-04	5	63	2	IPR005946
Domain	Pribosyltran_N	PRPS2 PRPS1	1.11e-04	5	63	2	IPR029099
Domain	Pribosyltran_N	PRPS2 PRPS1	1.11e-04	5	63	2	PF13793
Domain	Pribosyl_synth	PRPS2 PRPS1	1.11e-04	5	63	2	PF14572
Domain	ARM-type_fold	GPRASP1 STAG1 PIK3CD IQCB1 NOC3L DIAPH1 RALGAPA2	1.41e-04	339	63	7	IPR016024
Domain	Helicase_C	RECQL CHD8 DHX33 HELLS	4.68e-04	107	63	4	PF00271
Domain	HELICc	RECQL CHD8 DHX33 HELLS	4.68e-04	107	63	4	SM00490
Domain	Helicase_C	RECQL CHD8 DHX33 HELLS	4.84e-04	108	63	4	IPR001650
Domain	HELICASE_CTER	RECQL CHD8 DHX33 HELLS	5.02e-04	109	63	4	PS51194
Domain	HELICASE_ATP_BIND_1	RECQL CHD8 DHX33 HELLS	5.02e-04	109	63	4	PS51192
Domain	DEXDc	RECQL CHD8 DHX33 HELLS	5.02e-04	109	63	4	SM00487
Domain	Helicase_ATP-bd	RECQL CHD8 DHX33 HELLS	5.19e-04	110	63	4	IPR014001
Domain	Pribosyltran	PRPS2 PRPS1	6.04e-04	11	63	2	PF00156
Domain	PRTase-like	PRPS2 PRPS1	7.23e-04	12	63	2	IPR029057
Domain	PRibTrfase_dom	PRPS2 PRPS1	7.23e-04	12	63	2	IPR000836
Domain	-	PRPS2 PRPS1	7.23e-04	12	63	2	3.40.50.2020
Domain	-	MAN2B1 NAGA	9.93e-04	14	63	2	2.60.40.1180
Domain	Glyco_hydro_b	MAN2B1 NAGA	1.14e-03	15	63	2	IPR013780
Domain	BAR	ARHGAP42 DNMBP	1.85e-03	19	63	2	PS51021
Domain	SNF2_N	CHD8 HELLS	5.20e-03	32	63	2	IPR000330
Domain	SNF2_N	CHD8 HELLS	5.20e-03	32	63	2	PF00176
Domain	Sc_DH/Rdtase_CS	HSD17B6 HSD17B4	6.20e-03	35	63	2	IPR020904
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 DHX33	6.20e-03	35	63	2	IPR002464
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MYH9 SYNE2 NOC3L POLRMT SMU1 RECQL CHD8 URB2 FH PGK1	3.09e-07	653	64	10	22586326
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	MYH9 NOC3L DIAPH1 POLRMT SMU1 RECQL URB2 FH HSD17B4 PGK1 SPDL1 HELLS PRPS1	1.62e-06	1425	64	13	30948266
Pubmed	[Increased activity of PRPP synthetase].	PRPS2 PRPS1	3.33e-06	2	64	2	18409517
Pubmed	Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.	DGCR6 DGCR6L	3.33e-06	2	64	2	22832905
Pubmed	PRPS1-mediated purine biosynthesis is critical for pluripotent stem cell survival and stemness.	PRPS2 PRPS1	3.33e-06	2	64	2	33493137
Pubmed	Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes.	DGCR6 DGCR6L	3.33e-06	2	64	2	15821931
Pubmed	Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase.	FH HELLS	3.33e-06	2	64	2	27302170
Pubmed	Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus.	DGCR6 DGCR6L	3.33e-06	2	64	2	11157784
Pubmed	Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript.	PRPS2 PRPS1	3.33e-06	2	64	2	2537655
Pubmed	A mouse gene (Dgcr6) related to the Drosophila gonadal gene is expressed in early embryogenesis and is the homolog of a human gene deleted in DiGeorge syndrome.	DGCR6 DGCR6L	3.33e-06	2	64	2	9605865
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PRPS2 ORC4 MYH9 ECHDC1 NOC3L DIAPH1 RECQL CHD8 PPIP5K2 FH HSD17B4 PRPS1	4.42e-06	1318	64	12	30463901
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	NBAS STAG1 CDK12 ECHDC1 POLRMT SMU1 RECQL DHX33 URB2	5.53e-06	704	64	9	29955894
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	NBAS CNOT11 SYNE2 DNMBP HELLS NIN	7.03e-06	251	64	6	29778605
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	NBAS FKBP15 ZNF106 CDK12 IQCB1 PEX19 DIAPH1 PPIP5K2 SPDL1	7.65e-06	733	64	9	34672954
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	PRPS2 ORC4 CNOT11 MYH9 SYNE2 DIAPH1 SMU1 RECQL HSD17B4 PGK1 HELLS PRPS1	9.08e-06	1415	64	12	28515276
Pubmed	Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.	PRPS2 PRPS1	9.99e-06	3	64	2	25816608
Pubmed	Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms.	PRPS2 PRPS1	9.99e-06	3	64	2	1314091
Pubmed	Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions.	PRPS2 PRPS1	9.99e-06	3	64	2	9366267
Pubmed	A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet.	NBAS PRPS1	9.99e-06	3	64	2	11954550
Pubmed	Molecular mechanism of c-Myc and PRPS1/2 against thiopurine resistance in Burkitt's lymphoma.	PRPS2 PRPS1	9.99e-06	3	64	2	32391636
Pubmed	Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes.	PRPS2 PRPS1	9.99e-06	3	64	2	1962753
Pubmed	Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase.	PRPS2 PRPS1	9.99e-06	3	64	2	26175007
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	PRPS2 FKBP15 ARID3A MAN2B1 ECHDC1 PEX19 DHX33	1.20e-05	419	64	7	33001583
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	FKBP15 MYH9 CDK12 DIAPH1 SMU1 RECQL CHD8 KDM6A PGK1 HELLS	1.54e-05	1014	64	10	32416067
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	CNOT11 MYH9 DGCR6 CHD8 DHX33 PGK1 HELLS PRPS1	1.88e-05	624	64	8	33729478
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	UBR1 MAN2B1 CDK12 POLRMT CHD8 PPIP5K2 HSD17B4 HELLS	2.51e-05	650	64	8	38777146
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	FRY STAG1 NAGA SMU1 CHD8 HSD17B4 PGK1	2.69e-05	475	64	7	31040226
Pubmed	Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.	PRPS2 FH PGK1 PRPS1	2.69e-05	93	64	4	27215380
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	MYH9 SYNE2 CHD8 DHX33 ARHGAP20	3.22e-05	197	64	5	20811636
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UBR1 MYH9 NOC3L DIAPH1 POLRMT SMU1 RECQL CHD8 DHX33 URB2 PGK1	3.32e-05	1353	64	11	29467282
Pubmed	Linkage of phosphoribosylpyrophosphate synthetases 1 and 2, Prps1 and Prps2, on the mouse X chromosome.	PRPS2 PRPS1	3.32e-05	5	64	2	7849396
Pubmed	Integration of cytogenetic with recombinational and physical maps of mouse chromosome 16.	DGCR6 DGCR6L	3.32e-05	5	64	2	10395793
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	MYH9 ARID3A CDK12 DIAPH1 SMU1 PGK1 SPDL1	4.02e-05	506	64	7	30890647
Pubmed	Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.	PRPS2 PRPS1	4.98e-05	6	64	2	24855946
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CDK12 CHD8 CACNA1G PPIP5K2 ARHGAP20 DNMBP NIN	5.32e-05	529	64	7	14621295
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PRPS2 EFCAB5 MYH9 STAG1 SYNE2 NOC3L PPIP5K2 HSD17B4 PGK1 INSYN2A PRPS1	5.90e-05	1442	64	11	35575683
Pubmed	Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.	PRPS2 FH PGK1 PRPS1	5.98e-05	114	64	4	28245920
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CDK12 SYNE2 CHD8 CACNA1G NIN	6.06e-05	225	64	5	12168954
Pubmed	Lsh, an epigenetic guardian of repetitive elements.	PGK1 HELLS	6.96e-05	7	64	2	15448183
Pubmed	Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments.	MYH9 DIAPH1	9.27e-05	8	64	2	26975831
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	ORC4 MYH9 STAG1 CDK12 DIAPH1 CHD8 HELLS	9.65e-05	582	64	7	20467437
Pubmed	Functional proteomics mapping of a human signaling pathway.	ZNF106 MAN2B1 STAG1 CDK12 PEX19 DIAPH1 KDM6A	1.06e-04	591	64	7	15231748
Pubmed	O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.	ORC4 CDK12 TMEM126B SMU1 PRPS1	1.07e-04	254	64	5	36604567
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	NBAS MYH9 DIAPH1 CHD8 CACNA1G FH PGK1 PRPS1	1.14e-04	807	64	8	30575818
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	EFCAB5 FKBP15 CNOT11 MYH9 NOC3L POLRMT HSD17B4 PRPS1	1.16e-04	809	64	8	32129710
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	ZNF106 MYH9 ARID3A RECQL CHD8 HELLS	1.68e-04	444	64	6	34795231
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ARID3A SMU1 RECQL CHD8 HSD17B4 KDM6A PGK1 HELLS PRPS1	1.81e-04	1103	64	9	34189442
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	EFCAB5 TRPV1 MYH9 CDK12 ECHDC1 FH HSD17B4 PRPS1	2.03e-04	878	64	8	37223481
Pubmed	Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation.	DGCR6 DGCR6L	2.17e-04	12	64	2	9383280
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	PRPS2 MYH9 CDK12 IQCB1 PEX19 DIAPH1 RECQL PGK1 PRPS1	2.45e-04	1149	64	9	35446349
Pubmed	Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1.	UBR1 ZNF106	2.57e-04	13	64	2	12434312
Pubmed	Genetic Hearing Loss Overview	MYH9 DIAPH1 PRPS1	2.98e-04	70	64	3	20301607
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	MYH9 STAG1 CDK12 SYNE2 PPIP5K2 PRPS1	3.11e-04	498	64	6	36634849
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	GPRASP1 FKBP15 FRY MYH9 SYNE2 DIAPH1 CHD8 PGK1	3.77e-04	963	64	8	28671696
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ORC4 CNOT11 CDK12 NOC3L POLRMT SMU1 CHD8 DHX33 URB2 DNMBP	3.85e-04	1497	64	10	31527615
Pubmed	Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target.	GPRASP1 MYH9	3.93e-04	16	64	2	16969126
Pubmed	Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.	KDM6A PGK1	4.45e-04	17	64	2	19571810
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	ORC4 SMU1 RECQL CHD8 FH HSD17B4	4.49e-04	534	64	6	35032548
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	ARID3A CDK12 KDM6A	4.92e-04	83	64	3	28794006
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	MYH9 DISC1 SMU1 FH PGK1 PRPS1	5.30e-04	551	64	6	34728620
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GPRASP1 NELL1 TRIM66 FRY DGCR6 STAG1 HSD17B4 KDM6A PGK1	5.52e-04	1285	64	9	35914814
Pubmed	Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice.	MYH9 SPDL1	5.59e-04	19	64	2	32888949
Pubmed	Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource.	TRIM66 ZNF106	5.59e-04	19	64	2	23912999
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	ZNF106 MYH9 MAN2B1 SYNE2 DIAPH1 POLRMT RECQL URB2 HELLS	5.90e-04	1297	64	9	33545068
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	MYH9 CDK12 IQCB1 FH RALGAPA2 PGK1	5.99e-04	564	64	6	21565611
Pubmed	Cloning and comparative mapping of the DiGeorge syndrome critical region in the mouse.	DGCR6 DGCR6L	6.20e-04	20	64	2	9740669
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SMU1 RECQL KDM6A PGK1	7.35e-04	220	64	4	35785414
Pubmed	LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex.	CDK12 PGK1	7.52e-04	22	64	2	25982273
Pubmed	Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation.	KDM6A PGK1	8.23e-04	23	64	2	22573614
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	PRPS2 TMEM126B POLRMT SMU1 RECQL DNMBP	8.55e-04	604	64	6	38803224
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	UBR1 MYH9 SYNE2 NAGA NOC3L RECQL FH HSD17B4 PGK1	8.58e-04	1367	64	9	32687490
Pubmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	DGCR6 DISC1 CACNA1G DGCR6L CCDC136	8.77e-04	402	64	5	24722188
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ORC4 ARID3A STAG1 RECQL CHD8 HELLS	8.84e-04	608	64	6	36089195
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ARID3A MAN2B1 CDK12 PIK3CD POLRMT CHD8 RALGAPA2 DNMBP	9.27e-04	1105	64	8	35748872
Pubmed	Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.	MYH9 STAG1 SMU1	9.48e-04	104	64	3	26167872
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	ORC4 ZNF106 CNOT11 POLRMT	1.05e-03	242	64	4	34011540
Pubmed	Nucleolar proteome dynamics.	ZNF106 MYH9 DHX33 URB2 HSD17B4	1.05e-03	419	64	5	15635413
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	CDK12 SMU1 CHD8 KDM6A	1.20e-03	251	64	4	31076518
Pubmed	Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.	DGCR6 DGCR6L	1.22e-03	28	64	2	10963672
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	NBAS SYNE2 NOC3L PEX19 POLRMT SMU1 RECQL HELLS PRPS1	1.23e-03	1440	64	9	30833792
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PRPS2 MYH9 MAN2B1 DIAPH1 RECQL FH DNMBP SPDL1 PRPS1	1.33e-03	1455	64	9	22863883
Pubmed	Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization.	DGCR6 DGCR6L	1.40e-03	30	64	2	9405660
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	NBAS TMEM126B SYNE2 NOC3L PEX19 POLRMT SMU1 HELLS NIN	1.54e-03	1487	64	9	33957083
Pubmed	Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2.	DGCR6 DGCR6L	1.70e-03	33	64	2	10704284
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	STAG1 CDK12 CHD8 HSD17B4 SPDL1	1.78e-03	472	64	5	38943005
Pubmed	A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.	MYH9 SMU1	1.80e-03	34	64	2	12577067
Pubmed	Proteomic analysis reveals novel binding partners of MIP-T3 in human cells.	MYH9 PGK1	1.80e-03	34	64	2	20391533
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	FKBP15 ARID3A RECQL	1.84e-03	131	64	3	34551306
Pubmed	ROR2 Downregulation Activates the MSX2/NSUN2/p21 Regulatory Axis and Promotes Dental Pulp Stem Cell Senescence.	HSD17B4 PGK1 PRPS1	1.84e-03	131	64	3	35356984
Cytoband	1q42.1	DISC1 FH	1.25e-04	12	64	2	1q42.1
Cytoband	22q11	DGCR6 NAGA	1.72e-04	14	64	2	22q11
Cytoband	Xp11.2	AKAP4 KDM6A	3.58e-04	20	64	2	Xp11.2
Cytoband	10q24.2	DNMBP HELLS	4.34e-04	22	64	2	10q24.2
Cytoband	17p13.2	TRPV1 DHX33	2.71e-03	55	64	2	17p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr3q13	USF3 IQCB1 GRAMD1C	3.69e-03	221	64	3	chr3q13
Coexpression	LEE_BMP2_TARGETS_DN	ORC4 NOC3L POLRMT RECQL DHX33 URB2 ARHGAP20 PGK1 SPDL1 HELLS PRPS1 NIN	1.66e-06	904	64	12	M2325
Coexpression	LEE_BMP2_TARGETS_DN	ORC4 NOC3L POLRMT RECQL DHX33 URB2 ARHGAP20 PGK1 SPDL1 HELLS PRPS1 NIN	2.04e-06	922	64	12	MM1068
Coexpression	HE_LIM_SUN_FETAL_LUNG_C5_LARGE_PRE_B_CELL	PRPS2 CNOT11 ARID3A STAG1 TMEM126B SYNE2 DIAPH1 RECQL NINJ1 FH DGCR6L SPDL1 HELLS PRPS1	4.10e-06	1363	64	14	M45782
Coexpression	NUYTTEN_NIPP1_TARGETS_DN	ARHGAP42 PRPS2 ORC4 ZNF106 USF3 TMEM126B SYNE2 PEX19 SMU1 RALGAPA2 PRPS1	5.72e-06	845	64	11	M18090
Coexpression	GSE16522_ANTI_CD3CD28_STIM_VS_UNSTIM_NAIVE_CD8_TCELL_DN	PRPS2 MYH9 MAN2B1 STAG1 RECQL HSD17B4	8.97e-06	198	64	6	M3667
Coexpression	PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP	PRPS2 STAG1 GRAMD1C KDM6A HELLS	1.16e-04	195	64	5	M13736
Coexpression	GSE16450_CTRL_VS_IFNA_12H_STIM_IMMATURE_NEURON_CELL_LINE_UP	NBAS NAGA DHX33 URB2 RALGAPA2	1.21e-04	197	64	5	M7403
Coexpression	GSE32986_GMCSF_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_DN	GPRASP1 PIK3CD SYNE2 CHD8 RALGAPA2	1.24e-04	198	64	5	M8624
Coexpression	GSE19888_CTRL_VS_A3R_ACTIVATION_MAST_CELL_UP	ZNF106 HSD17B6 CHD8 CCDC136 INSYN2A	1.27e-04	199	64	5	M7325
Coexpression	GSE1740_MCSF_VS_MCSF_AND_IFNG_DAY2_DERIVED_MACROPHAGE_DN	DHX33 FH HSD17B4 SPDL1 PRPS1	1.27e-04	199	64	5	M6157
Coexpression	GSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_2H_UP	PRPS2 FRY MYH9 SYNE2 PEX19	1.30e-04	200	64	5	M6090
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	GPRASP1 MYH9 USF3 PIK3CD NIN	3.33e-06	159	64	5	2881b054bbeb479221ee3c38bbd9b0815b123579
Disease	Mental Retardation, Psychosocial	FRY STAG1 DISC1 CHD8 CACNA1G	1.04e-05	139	61	5	C0025363
Disease	Profound Mental Retardation	FRY STAG1 DISC1 CHD8 CACNA1G	1.04e-05	139	61	5	C0020796
Disease	Mental deficiency	FRY STAG1 DISC1 CHD8 CACNA1G	1.04e-05	139	61	5	C0917816
Disease	Intellectual Disability	KLF8 FRY STAG1 DISC1 DIAPH1 CHD8 CACNA1G	3.76e-05	447	61	7	C3714756
Disease	proline measurement, amino acid measurement	DGCR6 DGCR6L	4.19e-05	5	61	2	EFO_0005134, EFO_0009773
Disease	Zellweger Spectrum	PEX19 HSD17B4	3.23e-04	13	61	2	C3658299
Disease	Zellweger-Like Syndrome	PEX19 HSD17B4	3.23e-04	13	61	2	C0751594
Disease	Adrenoleukodystrophy, Neonatal	PEX19 HSD17B4	4.34e-04	15	61	2	C0282525
Disease	Zellweger Syndrome	PEX19 HSD17B4	4.95e-04	16	61	2	C0043459
Disease	systemising measurement	NBAS PIK3CD	8.61e-04	21	61	2	EFO_0010221
Disease	multisite chronic pain	STAG1 MAML3 INKA2	1.02e-03	95	61	3	EFO_0010100
Disease	hearing impairment	DIAPH1 HSD17B4 PRPS1	1.11e-03	98	61	3	C1384666
Disease	proline measurement	DGCR6 DGCR6L	1.32e-03	26	61	2	EFO_0009773
Disease	Autosomal dominant nonsyndromic hearing loss	MYH9 DIAPH1	1.65e-03	29	61	2	cv:C5779548

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSSQLIIMLLKNFML	TDRD1	1066	Q9BXT4
IIMLLKNFMLNQNVM	TDRD1	1071	Q9BXT4
MLIQMKLSLVLNFRK	URB2	1011	Q14146
IVMLEQLKSSLIMLQ	GRAMD1C	631	Q8IYS0
EQVQKLQAILKPMML	CHD8	1016	Q9HCK8
MQNILAVLLSQLMKT	CDK12	1206	Q9NYV4
MSNIVLMLIQKLLNE	AKAP4	626	Q5JQC9
MQMVIKVSKQLLAAL	DNMBP	831	Q6XZF7
QELMLQMNLLELIRK	DGCR6	171	Q14129
QVLVLFEQMLLDMNL	DIAPH1	91	O60610
QMVKETLQAMILQLQ	DISC1	816	Q9NRI5
VDLKAQLQMMENLIS	INSYN2A	356	Q6ZSG2
LMKLLLDNTQIMNAL	ORC4	401	O43929
VNLKLQNIMMLLRKC	HELLS	556	Q9NRZ9
AAIMKQMLIDQRAQL	MAML3	736	Q96JK9
MMGALQELKLLQVQT	INKA2	36	Q9NTI7
VMMLQLLEKVIELEN	ECHDC1	81	Q9NTX5
QGQKLEMMLEQKLAL	KIAA2026	181	Q5HYC2
QKLMLEQLESQFVLM	KDM6A	491	O15550
TIMNTIKMVTLQLLN	FKBP15	916	Q5T1M5
MLLTLFLITQLKMLN	MT-ATP8	16	P03928
MVDMDKLINNLEVQL	KLF8	1	O95600
METLQSQLMAEKLQL	MYH9	871	P35579
IQLINNMLDKVNEMI	PGK1	221	P00558
MLQILLRITEAVMQK	RALGAPA2	566	Q2PPJ7
LQQMKDIEKLRLLMN	NBAS	906	A2RRP1
LVQGIMDLQELLAKM	NELL1	236	Q92832
MLDIALLMANASQLK	NINJ1	51	Q92982
ILPIMQSIMQNLLSK	PEX19	171	P40855
MLLELQESIQLLNSM	EFCAB5	1331	A4FU69
MNMLKVNLIGVIQVT	HSD17B6	131	O14756
LQRQLVVLMKTMDNV	CACNA1G	851	O43497
NKLMNESLMLVTALN	FH	446	P07954
ARGNIMLSQKLQMIL	HSD17B4	716	P51659
SVMLQLLAMKVPNVL	DHX33	441	Q9H6R0
QELMLQMNLLELIRK	DGCR6L	171	Q9BY27
GLLMEIMNMNQQLLL	MAN2B1	621	O00754
MMLQNILQINSGDLL	IQCB1	186	Q15051
DILLESMMQNLKQVF	CYP7B1	151	O75881
ISMQLMQILEAKLFV	FRY	1276	Q5TBA9
VQMELGKLLAEMLVQ	POLRMT	571	O00411
MSSNTMLQKTLLILI	NXPE1	1	Q8N323
NIIVLIVPLMNDMSK	NOC3L	361	Q8WTT2
VLKMLLNLSENLFMT	GPRASP1	1296	Q5JY77
LQMEGQKLINQSLVM	ARHGAP20	891	Q9P2F6
QTQMKLMAIPLVFQI	TMEM126B	191	Q8IUX1
LVSKTQLEMNLPLMI	SYNE2	661	Q8WXH0
LKNQISQLQEQLMML	NIN	1196	Q8N4C6
MMNIKFQNIVVEILI	ARHGAP42	551	A6NI28
EQMQRMKLQIATLLQ	SPDL1	291	Q96EA4
MQLQLQTELRQLKVM	CCDC136	391	Q96JN2
MKLQAVMETLLQRQQ	ARID3A	1	Q99856
LVAIEMLLKLMQSSQ	CNOT11	376	Q9UKZ1
ISLMEDQLMVLKQLG	RECQL	141	P46063
LLRQTDPMIMLKQTQ	SMU1	96	Q2TAY7
LNMLIALMGETVNKI	TRPV1	676	Q8NER1
NLMELLIMINACKIA	PRPS2	66	P11908
MNFALILMINTLLAL	MT-ND3	1	P03897
LKLVGIQIQTLMQKM	TCN1	61	P20061
IAIQMQLKNILLMFQ	UBR1	536	Q8IWV7
QDMLTLQMIQLMDVL	PIK3CD	786	O00329
AMKLMTALVNVALNL	STAG1	226	Q8WVM7
KNILPLNSAMQVIQM	USF3	521	Q68DE3
NLMELLIMINACKIA	PRPS1	66	P60891
ILVQMVKSANMNGLL	PPIP5K2	591	O43314
MVLMNELNKQANGLI	TRIM66	156	O15016
VEVQRLLMLKQQITM	ZNF106	1086	Q9H2Y7
AQNMDILQNPLMIKI	NAGA	291	P17050