Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of nervous system process

S100B SLC8A2 TENM4 SYNE1 ZMYND8 EIF2AK3

9.61e-06175586GO:0031644
GeneOntologyBiologicalProcessamide transport

OSBP PER2 TIAM1 LRP1 LRP2 PLCB1 CHD7 HTT

2.17e-05420588GO:0042886
GeneOntologyBiologicalProcesspeptide hormone secretion

OSBP PER2 TIAM1 LRP1 PLCB1 CHD7 HTT

4.06e-05334587GO:0030072
GeneOntologyBiologicalProcesspeptide secretion

OSBP PER2 TIAM1 LRP1 PLCB1 CHD7 HTT

4.80e-05343587GO:0002790
GeneOntologyBiologicalProcessregulation of nervous system development

S100B TENM4 PER2 TIAM1 LRP1 LRP2 MACF1 CHD7 EIF2AK3

5.75e-05625589GO:0051960
GeneOntologyBiologicalProcesspeptide transport

OSBP PER2 TIAM1 LRP1 PLCB1 CHD7 HTT

5.96e-05355587GO:0015833
GeneOntologyBiologicalProcesspositive regulation of lysosomal protein catabolic process

LRP1 LRP2

7.73e-055582GO:1905167
GeneOntologyBiologicalProcesschemoattraction of axon

LRP1 LRP2

7.73e-055582GO:0061642
GeneOntologyBiologicalProcesspositive regulation of protein binding

TIAM1 SPTA1 LRP1 EIF2AK3

9.62e-0585584GO:0032092
GeneOntologyBiologicalProcessregulation of binding

RNF220 PER2 TIAM1 SPTA1 LRP1 EFHB EIF2AK3

1.18e-04396587GO:0051098
GeneOntologyBiologicalProcessinsulin secretion

OSBP PER2 TIAM1 LRP1 PLCB1 HTT

1.18e-04274586GO:0030073
GeneOntologyBiologicalProcessregulation of peptide hormone secretion

OSBP PER2 TIAM1 LRP1 PLCB1 CHD7

1.25e-04277586GO:0090276
GeneOntologyBiologicalProcessregulation of peptide transport

OSBP PER2 TIAM1 LRP1 PLCB1 CHD7

1.38e-04282586GO:0090087
GeneOntologyBiologicalProcessregulation of peptide secretion

OSBP PER2 TIAM1 LRP1 PLCB1 CHD7

1.38e-04282586GO:0002791
GeneOntologyBiologicalProcessregulation of receptor internalization

RNF220 RIN3 SYNE1 LRP1

1.48e-0495584GO:0002090
GeneOntologyBiologicalProcesspositive regulation of protein catabolic process in the vacuole

LRP1 LRP2

1.62e-047582GO:1904352
GeneOntologyBiologicalProcesslactate biosynthetic process

PER2 HTT

1.62e-047582GO:0019249
GeneOntologyBiologicalProcessneuron development

S100B RNF220 THBS4 TENM4 TIAM1 TENM3 SYNE1 ZMYND8 LRP1 LRP2 MACF1 PCARE HTT

1.69e-0414635813GO:0048666
GeneOntologyBiologicalProcesshormone secretion

OSBP PER2 TIAM1 LRP1 PLCB1 CHD7 HTT

1.70e-04420587GO:0046879
GeneOntologyBiologicalProcesschromatin organization

UIMC1 KMT2C KANSL2 PER2 BAZ1A ZMYND8 CHD7 JADE1 NSD3 BAHCC1

1.78e-048965810GO:0006325
GeneOntologyBiologicalProcessregulation of postsynaptic neurotransmitter receptor internalization

RNF220 SYNE1 LRP1

1.79e-0439583GO:0099149
GeneOntologyBiologicalProcesshormone transport

OSBP PER2 TIAM1 LRP1 PLCB1 CHD7 HTT

2.02e-04432587GO:0009914
GeneOntologyBiologicalProcesspositive regulation of Schwann cell migration

TIAM1 LRP1

2.15e-048582GO:1900149
GeneOntologyBiologicalProcessventricular compact myocardium morphogenesis

LRP2 CHD7

2.76e-049582GO:0003223
GeneOntologyBiologicalProcesspostsynaptic endocytosis

RNF220 SYNE1 LRP1

3.99e-0451583GO:0140239
GeneOntologyBiologicalProcesspostsynaptic neurotransmitter receptor internalization

RNF220 SYNE1 LRP1

3.99e-0451583GO:0098884
GeneOntologyBiologicalProcessprotein-DNA complex organization

UIMC1 KMT2C KANSL2 PER2 BAZ1A ZMYND8 CHD7 JADE1 NSD3 BAHCC1

4.26e-049995810GO:0071824
GeneOntologyBiologicalProcessregulation of protein binding

TIAM1 SPTA1 LRP1 EFHB EIF2AK3

4.49e-04228585GO:0043393
GeneOntologyBiologicalProcessregulation of hormone secretion

OSBP PER2 TIAM1 LRP1 PLCB1 CHD7

4.75e-04355586GO:0046883
GeneOntologyBiologicalProcessregulation of insulin secretion

OSBP PER2 TIAM1 LRP1 PLCB1

4.77e-04231585GO:0050796
GeneOntologyBiologicalProcessregulation of lysosomal protein catabolic process

LRP1 LRP2

5.04e-0412582GO:1905165
GeneOntologyBiologicalProcessresponse to radiation

UIMC1 PER2 SYNE1 LRP2 CASP7 PCARE HTT

5.05e-04503587GO:0009314
GeneOntologyBiologicalProcesscardiac septum development

LRP1 LRP2 SALL4 CHD7

5.51e-04134584GO:0003279
GeneOntologyBiologicalProcessregulation of Wnt signaling pathway

USP34 RNF220 TIAM1 LRP1 MACF1 JADE1

5.73e-04368586GO:0030111
GeneOntologyBiologicalProcessregulation of neurogenesis

TENM4 PER2 TIAM1 LRP1 LRP2 MACF1 CHD7

5.81e-04515587GO:0050767
GeneOntologyBiologicalProcessneurotransmitter receptor internalization

RNF220 SYNE1 LRP1

5.83e-0458583GO:0099590
GeneOntologyBiologicalProcessregulation of Schwann cell migration

TIAM1 LRP1

5.94e-0413582GO:1900147
GeneOntologyBiologicalProcessintracellular chemical homeostasis

S100B SLC8A2 OSBP TIAM1 LRP1 PLCB1 HKDC1 CHD7 HTT

6.52e-04866589GO:0055082
GeneOntologyBiologicalProcessregulation of protein catabolic process in the vacuole

LRP1 LRP2

6.92e-0414582GO:1904350
GeneOntologyBiologicalProcessSchwann cell migration

TIAM1 LRP1

6.92e-0414582GO:0036135
GeneOntologyBiologicalProcessmodulation of excitatory postsynaptic potential

SLC8A2 SYNE1 ZMYND8

8.14e-0465583GO:0098815
GeneOntologyBiologicalProcessregulation of myelination

S100B TENM4 EIF2AK3

8.90e-0467583GO:0031641
GeneOntologyBiologicalProcessdevelopmental growth

KMT2C S100B TENM4 TIAM1 LRP1 PLCB1 MACF1 SALL4 CHD7

9.35e-04911589GO:0048589
GeneOntologyBiologicalProcessregulation of receptor-mediated endocytosis

RNF220 RIN3 SYNE1 LRP1

9.72e-04156584GO:0048259
GeneOntologyBiologicalProcesspositive regulation of glial cell migration

TIAM1 LRP1

1.03e-0317582GO:1903977
GeneOntologyBiologicalProcessheart development

TENM4 SYNE1 LRP1 LRP2 CASP7 SALL4 CHD7 DNAAF1

1.20e-03757588GO:0007507
DomainPHD

KMT2C BAZ1A ZMYND8 JADE1 NSD3

3.54e-0675585PF00628
DomainZnf_PHD-finger

KMT2C BAZ1A ZMYND8 JADE1 NSD3

4.58e-0679585IPR019787
Domain-

TENM4 TENM3 LRP1 LRP2

6.35e-06395842.120.10.30
DomainPHD

KMT2C BAZ1A ZMYND8 JADE1 NSD3

8.24e-0689585SM00249
DomainZnf_PHD

KMT2C BAZ1A ZMYND8 JADE1 NSD3

9.18e-0691585IPR001965
DomainZF_PHD_2

KMT2C BAZ1A ZMYND8 JADE1 NSD3

1.13e-0595585PS50016
DomainZF_PHD_1

KMT2C BAZ1A ZMYND8 JADE1 NSD3

1.19e-0596585PS01359
Domain6-blade_b-propeller_TolB-like

TENM4 TENM3 LRP1 LRP2

1.24e-0546584IPR011042
DomainRhs_assc_core

TENM4 TENM3

2.84e-053582IPR022385
DomainSpectrin

SYNE1 SPTA1 MACF1

4.82e-0523583PF00435
DomainZinc_finger_PHD-type_CS

BAZ1A ZMYND8 JADE1 NSD3

4.92e-0565584IPR019786
DomainTox-GHH_dom

TENM4 TENM3

5.66e-054582IPR028916
DomainTen_N

TENM4 TENM3

5.66e-054582IPR009471
DomainTen_N

TENM4 TENM3

5.66e-054582PF06484
DomainTENEURIN_N

TENM4 TENM3

5.66e-054582PS51361
DomainTox-GHH

TENM4 TENM3

5.66e-054582PF15636
DomainEGF_3

THBS4 TENM4 ZAN TENM3 LRP1 LRP2

8.72e-05235586PS50026
DomainEGF

THBS4 TENM4 ZAN TENM3 LRP1 LRP2

8.72e-05235586SM00181
DomainZnf_FYVE_PHD

KMT2C BAZ1A ZMYND8 JADE1 NSD3

9.24e-05147585IPR011011
DomainYD

TENM4 TENM3

9.42e-055582IPR006530
DomainSpectrin_repeat

SYNE1 SPTA1 MACF1

9.81e-0529583IPR002017
DomainEGF-like_dom

THBS4 TENM4 ZAN TENM3 LRP1 LRP2

1.20e-04249586IPR000742
DomainSpectrin/alpha-actinin

SYNE1 SPTA1 MACF1

1.32e-0432583IPR018159
DomainSPEC

SYNE1 SPTA1 MACF1

1.32e-0432583SM00150
DomainEGF_1

THBS4 TENM4 ZAN TENM3 LRP1 LRP2

1.36e-04255586PS00022
DomainEGF-like_CS

THBS4 TENM4 ZAN TENM3 LRP1 LRP2

1.55e-04261586IPR013032
DomainEGF_2

THBS4 TENM4 ZAN TENM3 LRP1 LRP2

1.68e-04265586PS01186
DomainLDLR_class-A_CS

TMPRSS15 LRP1 LRP2

2.59e-0440583IPR023415
DomainLdl_recept_a

TMPRSS15 LRP1 LRP2

3.68e-0445583PF00057
Domain-

TMPRSS15 LRP1 LRP2

3.92e-04465834.10.400.10
DomainLDLRA_1

TMPRSS15 LRP1 LRP2

4.45e-0448583PS01209
DomainLDLRA_2

TMPRSS15 LRP1 LRP2

4.73e-0449583PS50068
DomainLDrepeatLR_classA_rpt

TMPRSS15 LRP1 LRP2

4.73e-0449583IPR002172
DomainLDLa

TMPRSS15 LRP1 LRP2

4.73e-0449583SM00192
DomainEGF

THBS4 ZAN LRP1 LRP2

6.32e-04126584PF00008
DomainNHL

TENM4 TENM3

7.23e-0413582PS51125
DomainTIL_dom

ZAN LRP2

8.42e-0414582IPR002919
DomainLdl_recept_b

LRP1 LRP2

8.42e-0414582PF00058
DomainLDLRB

LRP1 LRP2

8.42e-0414582PS51120
DomainEGF_extracell

TENM4 TENM3 LRP2

8.58e-0460583IPR013111
DomainEGF_2

TENM4 TENM3 LRP2

8.58e-0460583PF07974
DomainLY

LRP1 LRP2

9.70e-0415582SM00135
DomainLDLR_classB_rpt

LRP1 LRP2

9.70e-0415582IPR000033
DomainPost-SET_dom

KMT2C NSD3

1.11e-0316582IPR003616
DomainPostSET

KMT2C NSD3

1.11e-0316582SM00508
DomainMAM_1

TMPRSS15 ZAN

1.11e-0316582PS00740
DomainPOST_SET

KMT2C NSD3

1.11e-0316582PS50868
DomainCarboxyPept-like_regulatory

TENM4 TENM3

1.25e-0317582IPR008969
DomainMAM

TMPRSS15 ZAN

1.25e-0317582SM00137
Domain-

S100B SPTA1 PLCB1 MACF1 EFHB

1.28e-032615851.10.238.10
DomainMAM

TMPRSS15 ZAN

1.40e-0318582PF00629
DomainMAM_dom

TMPRSS15 ZAN

1.40e-0318582IPR000998
DomainMAM_2

TMPRSS15 ZAN

1.40e-0318582PS50060
DomainEFh

S100B SPTA1 MACF1 EFHB

1.47e-03158584SM00054
DomainPWWP

ZMYND8 NSD3

1.74e-0320582SM00293
DomainEF-hand-dom_pair

S100B SPTA1 PLCB1 MACF1 EFHB

1.95e-03287585IPR011992
DomainEPHD

KMT2C JADE1

2.10e-0322582PS51805
DomainActinin_actin-bd_CS

SYNE1 MACF1

2.30e-0323582IPR001589
DomainPWWP

ZMYND8 NSD3

2.30e-0323582PF00855
DomainPWWP_dom

ZMYND8 NSD3

2.30e-0323582IPR000313
DomainACTININ_2

SYNE1 MACF1

2.30e-0323582PS00020
DomainACTININ_1

SYNE1 MACF1

2.30e-0323582PS00019
DomainEGF_CA

THBS4 LRP1 LRP2

2.42e-0386583PF07645
DomainPWWP

ZMYND8 NSD3

2.50e-0324582PS50812
Domain-

KMT2C RNF220 BAZ1A ZMYND8 JADE1 NSD3

2.63e-034495863.30.40.10
DomainZnf_RING/FYVE/PHD

KMT2C RNF220 BAZ1A ZMYND8 JADE1 NSD3

2.93e-03459586IPR013083
DomaincEGF

LRP1 LRP2

2.94e-0326582IPR026823
DomaincEGF

LRP1 LRP2

2.94e-0326582PF12662
DomainEGF_Ca-bd_CS

THBS4 LRP1 LRP2

3.41e-0397583IPR018097
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB1 CASP7 HTT

4.81e-0523443M47676
PathwayWP_ALZHEIMERS_DISEASE

LRP1 PLCB1 CASP7 EIF2AK3

8.10e-0574444MM15962
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

USP34 KMT2C TENM4 SYNE1 PLCB1 MACF1 CHD7

9.81e-0822558712168954
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NHSL1 USP34 KMT2C RIN3 PER2 ADAMTS7 POLE JADE1 HTT NSD3 SPATA13 BAHCC1

2.31e-071105581235748872
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

LRP2 HKDC1 CASP7 CHD7 DHTKD1 EIF2AK3 HTT

9.07e-0731358720800603
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

USP34 S100B RNF220 KANSL2 TIAM1 MTIF2 SYNE1 ZMYND8 LRP1 LRP2 MACF1 USP9Y

1.14e-061285581235914814
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

USP34 ATXN7L1 MTIF2 ZMYND8 LRP1 LRP2 MACF1 DDX24 DNTTIP2 NSD3 BAHCC1

2.02e-061116581131753913
Pubmed

Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.

LRP1 LRP2

2.73e-06258234445520
Pubmed

Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding.

PER2 HTT

2.73e-06258220668203
Pubmed

Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands.

TENM4 TENM3

2.73e-06258235484136
Pubmed

Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.

SYNE1 MACF1 HEATR5B

4.92e-062058321689717
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

USP34 KMT2C BAZ1A LRP2 MACF1 SALL4 CHD7 JADE1 DNTTIP2 ESF1

1.11e-051084581011544199
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

TENM3 SYNE1 SPTA1 PLCB1 GAN

1.55e-0518758526460568
Pubmed

Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.

TENM4 TENM3

1.64e-05458210225957
Pubmed

Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.

LRP1 LRP2

1.64e-05458212413896
Pubmed

Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.

LRP1 LRP2

1.64e-0545827775583
Pubmed

Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E.

LRP1 LRP2

1.64e-05458211421580
Pubmed

All four members of the Ten-m/Odz family of transmembrane proteins form dimers.

TENM4 TENM3

1.64e-05458212000766
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

USP34 SYNE1 WSCD2 MACF1

2.52e-051015849872452
Pubmed

ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association.

LRP1 LRP2

2.72e-05558216101684
Pubmed

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

CASP7 HTT

2.72e-05558214713958
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP1 LRP2

2.72e-05558219047013
Pubmed

Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.

LRP1 LRP2

2.72e-05558218685438
Pubmed

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.

LRP1 LRP2

4.08e-0565829837937
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

UIMC1 KMT2C KANSL2 BAZ1A SPTA1 ZMYND8 CHD7 DDX24 DNTTIP2 NSD3

5.04e-051294581030804502
Pubmed

Functional proteomics mapping of a human signaling pathway.

UIMC1 UBXN11 TENM3 BAZ1A ZMYND8 LRP1 MACF1

5.61e-0559158715231748
Pubmed

The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles.

TENM4 TENM3

5.71e-05758210625539
Pubmed

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.

LRP1 LRP2

5.71e-05758212169628
Pubmed

Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.

OSBP LRP1

5.71e-05758229547901
Pubmed

The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.

TENM4 TENM3

5.71e-05758212915301
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TENM4 PER2 TENM3 SYNE1 MACF1 SPATA13

5.99e-0540758612693553
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

UIMC1 RNF220 BAZ1A CHD7 DDX24 DNTTIP2 NSD3

6.70e-0560858736089195
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

OSBP LRP1 LRP2

6.77e-054758311208732
Pubmed

Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.

TENM4 TENM3

7.60e-05858210331952
Pubmed

Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation.

CASP7 EIF2AK3

7.60e-05858211555640
Pubmed

LDL receptor-related protein as a component of the midkine receptor.

LRP1 LRP2

9.77e-05958210772929
Pubmed

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.

CASP7 HTT

9.77e-0595829535906
Pubmed

Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.

USP34 USP9Y

9.77e-05958237149635
Pubmed

Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation.

RNF220 HTT

9.77e-05958235701899
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

USP34 POLE MACF1 CHD7 DDX24 DNTTIP2 ESF1

1.04e-0465358722586326
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

ZMYND8 DDX24 DNTTIP2 ESF1

1.12e-0414858432538781
Pubmed

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.

KMT2C NSD3

1.22e-041058222421440
Pubmed

Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.

TENM4 TENM3

1.22e-041058238713721
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

UIMC1 BAZ1A SYNE1 SPTA1 HKDC1 MACF1 DNTTIP2 ESF1 SPATA13 BAHCC1

1.24e-041442581035575683
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

NHSL1 TENM4 CHD7 HEATR5B

1.27e-0415358410718198
Pubmed

A forward genetic screen in mice identifies mutants with abnormal cortical patterning.

LRP2 DNAAF1

1.49e-041158223968836
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP2

1.49e-041158224639464
Pubmed

Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner.

THBS4 EIF2AK3

1.49e-041158238678560
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TIAM1 MTIF2 SYNE1 POLE CNDP2 MACF1 DDX24 EIF2AK3 DNTTIP2 ESF1

1.59e-041487581033957083
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

UIMC1 KMT2C BAZ1A SYNE1 ZMYND8 MACF1 CHD7 HEATR5B ESF1 NSD3

1.68e-041497581031527615
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

UIMC1 BAZ1A ZMYND8 CHD7 DDX24 DNTTIP2 ESF1 NSD3

1.77e-0495458836373674
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

USP34 KMT2C TENM3 BAZ1A MACF1

2.02e-0432258526514267
Pubmed

DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells.

CASP7 SALL4

2.11e-041358225418731
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

TENM4 LRP1 LRP2

2.32e-047158333541421
Pubmed

Tagging genes with cassette-exchange sites.

KMT2C RNF220 ZMYND8 MACF1 JADE1

2.43e-0433558515741177
Pubmed

Stage-specific association of apolipoprotein A-I and E in developing mouse retina.

LRP1 LRP2

2.46e-041458217389516
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

LRP1 LRP2

2.46e-041458215082773
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

UIMC1 USP34 BAZ1A POLE ZMYND8 CNDP2 ESF1 NSD3

2.68e-04101458832416067
Pubmed

Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes.

LRP1 CASP7

2.83e-041558220468060
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

UIMC1 OSBP KANSL2 ZMYND8 CHD7 DDX24 ESF1

2.95e-0477458715302935
Pubmed

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.

LRP1 LRP2

4.11e-041858210827173
Pubmed

Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.

TENM3 POLE

4.59e-041958214671302
Pubmed

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

TENM4 SYNE1

4.59e-041958218711365
Pubmed

Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures.

S100B LRP1

4.59e-041958232579270
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

BAZ1A ZMYND8 CHD7 DDX24 NSD3

5.09e-0439458527248496
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

KANSL2 BAZ1A POLE ZMYND8 LRP1 DDX24 EIF2AK3

5.43e-0485758725609649
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP1 LRP2

5.62e-042158221337463
Pubmed

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.

LRP2 HKDC1 MACF1 PCARE

6.27e-0423358432290105
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

SYNE1 MACF1 PCARE DDX24

6.37e-0423458436243803
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

USP34 ZMYND8 LRP1 LRP2 CHD7

6.65e-0441858534709266
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

OSBP POLE PLCB1 CHD7 DNAAF1 ESF1

6.71e-0463858631182584
Pubmed

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.

CHD7 DHTKD1 SPATA32 DNTTIP2 HTT

6.72e-0441958533001583
Pubmed

Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.

MTIF2 LRP2

6.76e-042358220468071
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ATXN7L1 SYNE1 MACF1

6.91e-0410358310574462
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

KMT2C TENM3 BAHCC1

6.91e-0410358310819331
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

SLC8A2 LRP1 LRP2

7.31e-0410558330280653
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

MTIF2 SYNE1 POLE LRP2 DDX24 DHTKD1 EIF2AK3 ESF1 FBXL4

7.82e-04149658932877691
Pubmed

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

KMT2C DDX24 DNTTIP2 ESF1

7.91e-0424858427926873
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

CHD7 DDX24 NSD3

8.15e-0410958333554859
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

SYNE1 LRP1 PLCB1 MACF1

8.28e-0425158427507650
Pubmed

Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.

SYNE1 PLCB1

9.34e-042758218649358
Pubmed

Rebalancing gene haploinsufficiency in vivo by targeting chromatin.

KMT2C SALL4

1.00e-032858227256596
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SYNE1 LRP1 PLCB1 MACF1 CHD7 FRMPD3 SPATA13

1.07e-0396358728671696
Pubmed

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.

CNDP2 CHD7

1.08e-032958223396134
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

KMT2C BAZ1A POLE SALL4 CHD7

1.11e-0346958527634302
Pubmed

A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.

S100B GPR162

1.15e-033058231065682
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

USP34 ZMYND8 MACF1 CHD7

1.27e-0328258423667531
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

ZMYND8 CHD7 DNTTIP2 ESF1

1.29e-0328358430585729
Pubmed

A human MAP kinase interactome.

KMT2C SYNE1 PLCB1 MACF1 NSD3

1.30e-0348658520936779
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

ATXN7L1 MACF1 BAHCC1

1.36e-0313058312421765
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

KMT2C ZMYND8 GAN USP9Y DDX24

1.44e-0349758536774506
Pubmed

Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex.

S100B THBS4

1.57e-033558235858542
Pubmed

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.

ZAN SPTA1

1.57e-033558219862010
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

BAZ1A POLE MACF1 DDX24 DNTTIP2 ESF1

1.63e-0375958635915203
InteractionH2BC21 interactions

UIMC1 RIN3 BAZ1A ATXN7L1 DBF4B ZMYND8 CHD7 JADE1 DNTTIP2 NSD3 BAHCC1

3.34e-066965711int:H2BC21
InteractionANKRD36B interactions

LRP1 LRP2 GAN CHD7

2.49e-0560574int:ANKRD36B
InteractionZNF330 interactions

BAZ1A POLE ZMYND8 CHD7 DDX24 DNTTIP2 ESF1 NSD3

3.45e-05446578int:ZNF330
GeneFamilyPHD finger proteins

KMT2C BAZ1A ZMYND8 JADE1 NSD3

1.05e-069037588
GeneFamilyLow density lipoprotein receptors

LRP1 LRP2

3.13e-0413372634
GeneFamilyPWWP domain containing

ZMYND8 NSD3

9.17e-04223721147
GeneFamilyEF-hand domain containing

S100B SPTA1 MACF1 EFHB

1.01e-03219374863
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2C NSD3

2.19e-0334372487
GeneFamilyPhospholipases

PLCB1 PLD5

3.33e-0342372467
GeneFamilyUbiquitin specific peptidases

USP34 USP9Y

5.85e-0356372366
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TIAM1 SPATA13

8.05e-0366372722
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

OSBP TIAM1 SPATA13

8.52e-03206373682
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS15 TENM4 ZAN SPTA1 LRP2 SALL4

1.46e-07184586ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS15 TENM4 ZAN SPTA1 LRP2 SALL4

1.46e-071845862cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS15 TENM4 ZAN SPTA1 LRP2 SALL4

1.46e-071845862b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NHSL1 S100B RNF220 LRP2 CHD7 SPATA13

1.51e-07185586b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NHSL1 S100B RNF220 LRP2 CHD7 SPATA13

1.71e-0718958642ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NHSL1 S100B RNF220 LRP2 CHD7 SPATA13

1.77e-0719058607f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NHSL1 S100B RNF220 LRP2 CHD7 SPATA13

1.82e-071915862b056cbe2e82e056e1f798974999378460eb1d16
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TENM3 SYNE1 LRP2 WSCD2 HKDC1

1.98e-06158585e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TENM3 SYNE1 LRP2 WSCD2 HKDC1

1.98e-06158585d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 CHD7 SPATA13

4.16e-06184585a2191dd5546efd357b23e625beb3c5820476f243
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 CHD7 SPATA13

4.51e-0618758597e520705491c8f52a32025311a9fa7b9176979a
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

USP34 KMT2C PLCB1 MACF1 EIF2AK3

4.62e-06188585ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NHSL1 S100B RNF220 CHD7 SPATA13

4.75e-0618958537ecbd73408d462b47d7e5611f203143e08a2689
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 CHD7 SPATA13

4.87e-06190585ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

UBXN11 SYNE1 EFHB DNAAF1 GPR162

5.52e-061955853486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

UBXN11 SYNE1 EFHB DNAAF1 GPR162

5.66e-06196585d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TENM3 SYNE1 LRP1 MACF1 SPATA13

5.81e-06197585fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP34 KMT2C SYNE1 MACF1 DDX24

5.81e-0619758557ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellcontrol-Epithelial-Ciliated|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

UBXN11 SYNE1 EFHB DNAAF1 GPR162

5.81e-06197585d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCellcontrol-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

UBXN11 SYNE1 EFHB DNAAF1 GPR162

5.81e-06197585e453d085182364ca347cbcc9dc995c62c3353016
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP34 SYNE1 MACF1 USP9Y DDX24

6.10e-06199585f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TENM3 SYNE1 LRP1 MACF1 SPATA13

6.10e-06199585e1849505b92820a219c5a2c35492bdd55579fb48
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TENM3 SYNE1 LRP1 MACF1 SPATA13

6.10e-06199585a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellfacs-Trachea-24m-Hematologic-myeloid-granulocyte-granulocyte_l8|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RIN3 CHD7 USP9Y SPATA13

4.73e-05153584338684d420b01e32918fa19048ccdda234942ce1
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

S100B TENM3 LRP1 GPR162

4.85e-051545845ed64bbf603290e6dc34f81d145982690b89dd0d
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

S100B UBXN11 POLE WSCD2

5.77e-051615849703b7e67d9fadb6129cad166bd01be915042e44
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZAN SPTA1 LRP2 PLD5

6.96e-0516958412bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NHSL1 DNAAF1 GPR162 SPATA13

7.28e-051715841854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

TENM3 SYNE1 LRP2 WSCD2

7.45e-0517258436a96714a0eb6ac438648135336c9791881ddadb
ToppCellwk_08-11-Mesenchymal-Fibroblast-Airway_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RIN3 TENM3 LRP1 WSCD2

7.62e-05173584b23b408acc29a667cce104429afef1a6cf2720a5
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

S100B SYNE1 MACF1 NSD3

8.32e-05177584d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

S100B SYNE1 MACF1 NSD3

8.32e-05177584f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

S100B SYNE1 MACF1 NSD3

8.32e-05177584936ab2b180a052387124f68d0c7f41c0b164e748
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

S100B SYNE1 MACF1 NSD3

8.32e-05177584d5aeda113afaa2425874394610344570c9078478
ToppCellCOVID-19_Mild-Lymphoid_T/NK-NK_activated|COVID-19_Mild / Disease group, lineage and cell class

S100B SYNE1 MACF1 NSD3

8.32e-051775846978a22fef40c8b455342373abe7593f5ede0fa4
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

TENM4 TENM3 LRP2 WSCD2

8.51e-05178584544379f5a6145429762258d426b876bb36c112f5
ToppCell5'-Adult-Appendix-Neuronal-Glial_mature|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

S100B TENM4 TENM3 ADAMTS7

9.07e-051815843aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

S100B TENM4 TENM3 ADAMTS7

9.07e-05181584997ba1be2824b00d684f2163d0114656ed11fa53
ToppCell5'-Adult-Appendix-Neuronal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

S100B TENM4 TENM3 ADAMTS7

9.07e-05181584e6b7e8dd5c13cc10ba22f2f5a8c669486f934bdc
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THBS4 LRP1 PLCB1 PLD5

9.27e-051825843dfa9187e9d2bab1d199079d29209c4648220ada
ToppCellCOVID-19_Mild-NK_activated|COVID-19_Mild / Disease condition and Cell class

S100B SYNE1 MACF1 NSD3

9.47e-0518358422bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 SPATA13

9.47e-051835845472cdce6d99314d229418412acf1fff6340db7d
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 SPATA13

9.67e-051845845939527d24d299e562e707469c9123890edd76be
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

S100B TENM3 PLCB1 WSCD2

9.87e-051855848ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCellBrain_organoid-organoid_Kanton_Nature|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.

BAZ1A CHD7 JADE1 NSD3

9.87e-05185584857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 SPATA13

9.87e-05185584b8d02c9426740ffcb69d2e6f95473b388149d297
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

S100B TENM3 PLCB1 WSCD2

9.87e-05185584b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

S100B RIN3 SYNE1 PLCB1

1.01e-04186584c984e5729958237b101df96d1c89a236faacded6
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 SPATA13

1.01e-04186584d57c40b3fe5cfc87e771df76533d9a3e94678b04
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 CHD7

1.03e-04187584b71d0cd91bc98e020757c1d071a13ad48d718bcf
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 CHD7

1.05e-04188584b04fd6a724c117eb9a979c29b91f90113feb7a5c
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 SPATA13

1.05e-0418858414072d0b82df55711d5356b2209f4f0bdd90dc27
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 CHD7

1.05e-0418858460242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NHSL1 S100B RNF220 CHD7

1.05e-04188584505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 CHD7

1.07e-0418958470eea8c94fa56bb15bee8065de47acea156794e9
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WSCD2 PLD5 FRMPD3 GPR162

1.07e-04189584f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NHSL1 S100B RNF220 CHD7

1.07e-04189584784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 SPATA13

1.09e-041905846b101359f397020a21e2bfd15851cb48e71f4502
ToppCellASK454-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

UBXN11 EFHB DNAAF1 GPR162

1.09e-041905845cea6480f08253d7adf484e511d3fdfa96641268
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 SPATA13

1.09e-04190584396b7225c2430db3dc55a3d0db70239b71987229
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

S100B RNF220 LRP2 CHD7

1.12e-041915842110a1dd10730ad7ee7a265fb1716ab3ddafcf4a
ToppCellIPF-Lymphoid-NK|Lymphoid / Disease state, Lineage and Cell class

S100B RIN3 SYNE1 PLCB1

1.12e-04191584f2ddc0962007d7a4e78fbd916ebb62fc557d480a
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NHSL1 S100B RNF220 CHD7

1.12e-04191584a90c8ab2077e52bbc998457c85a1b9867f9c8c93
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 MACF1 USP9Y DDX24

1.16e-041935849337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP34 PER2 MACF1 NSD3

1.19e-04194584e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

USP34 RNF220 DDX24 GPR162

1.19e-041945848aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BAZ1A SYNE1 MACF1 FRMPD3

1.23e-04196584ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TENM3 SYNE1 WSCD2 PCARE

1.23e-04196584545d2e4469924d333e3f655f559c899fa1260196
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

TENM4 TENM3 MACF1 SPATA13

1.26e-04197584f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellTracheal-10x5prime-Stromal-Chondrocytic-Chondrocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

S100B TENM3 LRP1 WSCD2

1.28e-0419858455f013e9e6587d9ece59751fa131b1d22d6cceea
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

UBXN11 SYNE1 EFHB DNAAF1

1.28e-04198584ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM4 SYNE1 PLCB1 DDX24

1.28e-041985848ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellTracheal-10x5prime-Stromal-Chondrocytic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

S100B TENM3 LRP1 WSCD2

1.28e-04198584c72ef2ddcbb6dacbed4c6200d89e17d57314dcdc
ToppCellmild-MAIT|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 PLCB1 MACF1 DDX24

1.31e-04199584cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TENM3 SYNE1 LRP1 SPATA13

1.31e-041995848b86c69aaf60feff53aa782559cfece7342a23de
ToppCellsevere-gd_T|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

S100B SYNE1 PLCB1 DDX24

1.31e-04199584e5a17a9f8f3be05d6abe1116607d17633df3c7ef
ToppCellBronchial-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TIAM1 TENM3 PLCB1 WSCD2

1.33e-04200584b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

USP34 KMT2C MACF1 CHD7

1.33e-04200584dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellTracheal-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TIAM1 TENM3 SYNE1 WSCD2

1.33e-04200584b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

S100B SYNE1 MACF1 USP9Y

1.33e-042005842281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellCOVID-19|World / Disease, condition lineage and cell class

KMT2C MACF1 DDX24 DNTTIP2

1.33e-042005847dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellTracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TIAM1 TENM3 SYNE1 WSCD2

1.33e-04200584f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP34 KMT2C MACF1 DDX24

1.33e-0420058412f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellmild-gd_T|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 PLCB1 MACF1 DDX24

1.33e-04200584109f673a4967ffa52270a0b4f818b3461288db44
ToppCellBronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TIAM1 TENM3 PLCB1 WSCD2

1.33e-042005847c673ad0ea503ebd196579684d25d5f9e6a41030
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)|Cerebellum / BrainAtlas - Mouse McCarroll V32

RIN3 ZAN ADAMTS7

1.86e-0485583bb9555652e93620d5aeeb71e915b3978a437407d
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

RIN3 ZAN ADAMTS7

1.86e-0485583f7935c3206310adafdecb75149c3b06c38e7780c
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

RIN3 ZAN ADAMTS7

1.86e-048558343f6911b032718d8ba75fb7bba5f9b536a4b3260
ToppCellEntopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

LRP2 EFHB DNAAF1

3.47e-04105583bfd3395c51a0e868aa92eac4e929de59a3fe8b50
ToppCellEntopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--|Entopeduncular / BrainAtlas - Mouse McCarroll V32

LRP2 EFHB DNAAF1

3.47e-0410558396566c83999aa625c84a4ed18a6df9daa99f9578
ToppCellEntopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

LRP2 EFHB DNAAF1

3.47e-0410558376b73bc9236030e0703868fa8f7ecee2affe565b
DrugIvermectin [70288-86-7]; Up 200; 4.6uM; PC3; HT_HG-U133A

TENM4 TIAM1 DBF4B ZMYND8 PLCB1 GAN BAHCC1

7.23e-071995875853_UP
Diseasepappalysin-1 measurement

USP34 CHD7

5.67e-056582EFO_0802845
Diseaselactate measurement

TENM3 PLCB1 SPATA13

6.26e-0539583EFO_0007745
Diseasetriacylglycerol 48:4 measurement

TENM4 PLD5

3.40e-0414582EFO_0010407
Diseasecongenital heart disease (implicated_via_orthology)

KMT2C LRP2 CHD7

3.44e-0469583DOID:1682 (implicated_via_orthology)
Diseaseamino acid measurement

RNF220 TENM4 SYNE1 LRP2 GAN GPR162 HTT

3.57e-04678587EFO_0005134
DiseaseProteinuria

ADAMTS7 LRP2

3.92e-0415582HP_0000093
DiseaseColorectal Carcinoma

KMT2C OSBP TIAM1 SYNE1 POLE LRP1 LRP2

4.39e-04702587C0009402
Diseasemyeloid white cell count

USP34 RIN3 KANSL2 PLCB1 HKDC1 CHD7 SPATA32 HTT

4.71e-04937588EFO_0007988
Diseaselymphocyte count

S100B KANSL2 TENM4 ZAN SPTA1 PLCB1 HKDC1 CHD7 SPATA32 HTT

5.18e-0414645810EFO_0004587
DiseaseChild Behaviour Checklist assessment

TENM4 TENM3

5.69e-0418582EFO_0005661
Diseasepain

LRP1 WSCD2 MACF1 ESF1

6.05e-04196584EFO_0003843
Diseasevital capacity

USP34 RIN3 SYNE1 LRP2 PLCB1 WSCD2 HKDC1 CHD7 EIF2AK3

6.46e-041236589EFO_0004312
Diseaseplatelet component distribution width

RIN3 DBF4B SYNE1 SPTA1 ZMYND8 PLCB1 MACF1

6.76e-04755587EFO_0007984
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

RIN3 LRP1 WSCD2 MACF1 HTT

7.45e-04364585EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseasechronic kidney disease

RIN3 ATXN7L1 LRP2 PLCB1

1.19e-03235584EFO_0003884
Diseasecorneal topography

NHSL1 THBS4 ADAMTS7

1.31e-03109583EFO_0004345
DiseaseAlzheimer's disease (is_marker_for)

S100B SLC8A2 PLCB1 CASP7

1.65e-03257584DOID:10652 (is_marker_for)
DiseaseIntellectual Disability

KMT2C SYNE1 LRP2 MACF1 HTT

1.85e-03447585C3714756

Protein segments in the cluster

PeptideGeneStartEntry
QSMEDSEEDCGGAPD

BAHCC1

1266

Q9P281
LTDCDVEDGTMDGND

EIF2AK3

766

Q9NZJ5
FLQMCDSAEEGVDGD

DHTKD1

716

Q96HY7
ALMDEEDEGSKFCEE

CHD7

1471

Q9P2D1
GEMDGADESEKLDCQ

ATXN7L1

441

Q9ULK2
NVGCDFEIDSGAMED

ADAMTS7

671

Q9UKP4
KKGDAENMVLCDGCD

BAZ1A

1156

Q9NRL2
SREGELMDCDGKSES

KMT2C

1236

Q8NEZ4
VKTGMDCGLSLDEDN

MTIF2

686

P46199
CVAIMSEEDGDDDGG

GPR162

341

Q16538
CNMFDDCGDGSDEED

LRP1

3761

Q07954
GEVNCPDGSDEDNKM

TMPRSS15

206

P98073
ENSTDGEMCDKDALE

ESF1

226

Q9H501
GEMCDKDALEEDSES

ESF1

231

Q9H501
ACDFLKEDGNDEVMT

NHSL1

1336

Q5SYE7
SDCDDSGKELGMLVE

PER2

56

O15055
DRDNDCGDMSDEKDC

LRP2

1291

P98164
DGDNDCGDMSDEDKR

LRP2

2926

P98164
CDEDNDCGDGSDELM

LRP2

3051

P98164
GKEADDNCLVMEFDD

POLE

1696

Q07864
DQCCSGKGDMSDEDD

OSBP

341

P22059
GKDCDVQGLEHDMEE

MACF1

5306

Q9UPN3
EEEDSDLAAKLGMCN

HTT

1876

P42858
DDMEKEACTVLGEGG

HEATR5B

1686

Q9P2D3
KGDDCLELESSMAES

DBF4B

6

Q8NFT6
IEDDAYAEKDGCGMD

FBXL4

246

Q9UKA2
CDMADDASDGKDELS

FRMPD3

1536

Q5JV73
GEDGEKELISMECYD

GAN

381

Q9H2C0
MADDQGCIEEQGVED

CASP7

1

P55210
KDPELEAQGDDMVCD

DDX24

121

Q9GZR7
EAQGDDMVCDDPEAG

DDX24

126

Q9GZR7
DDETGKSLEDQNMCF

DNAAF1

556

Q8NEP3
KGDGMIDKDELQEAC

EFHB

576

Q8N7U6
EFSDDLDVVGDGMQC

KANSL2

406

Q9H9L4
DTEDKEGCQMDKEPS

ZMYND8

616

Q9ULU4
DCHRENGGSSEDMKE

SALL4

131

Q9UJQ4
AEAAKSEELSCEMEG

PCARE

811

A6NGG8
GKGEEEEEEDGMRLC

RIN3

21

Q8TB24
IMGEDEDGLSEKNCQ

PLD5

91

Q8N7P1
GEELDGCNSKLMELD

SYNE1

5466

Q8NF91
GFKATDCEGEDVVDM

HKDC1

621

Q2TB90
CCGKGSVEVAEMRDD

SPATA32

11

Q96LK8
KVMETLDNDGDGECD

S100B

56

P04271
KQDEGQREGSCMAED

RNF220

326

Q5VTB9
MCSGKENPDSDADLD

RNF220

381

Q5VTB9
SPDGEDGNEMVFCDK

JADE1

211

Q6IE81
CLEGMEESGSEGLDE

CNDP2

161

Q96KP4
EMELVDLGDGRDKDC

SPATA13

506

Q96N96
DMNSEGNVDFECDTK

DNTTIP2

411

Q5QJE6
CDDDMDGDGIKNILD

THBS4

566

P35443
GSAEEKDCEEARGME

TIAM1

201

Q13009
SKDNDGDGLVDCMDP

TENM4

841

Q6N022
AMETLCTDSKDNEGD

TENM3

776

Q9P273
IECSACDGNEEAMKE

SPTA1

1566

P02549
KFDDGDVTECKMDDD

USP9Y

1901

O00507
DDDDCKKSSMDEGTA

PLCB1

516

Q9NQ66
QCGDGGELVMCDKKD

NSD3

1326

Q9BZ95
EKNMADFDGEESGCE

USP34

786

Q70CQ2
SEAECDMECKGERGS

WSCD2

191

Q2TBF2
QASEKNECISEDMGD

UIMC1

341

Q96RL1
EVDMLSDGCGSEEKI

UBXN11

36

Q5T124
CGMCGNFNDEEEDEL

ZAN

2066

Q9Y493
ACGELEFGDDETMKT

SLC8A2

576

Q9UPR5