Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine binding	CHRFAM7A CHRNA7	4.16e-04	13	47	2	GO:0042166
GeneOntologyMolecularFunction	chloride channel regulator activity	CHRFAM7A CHRNA7	5.58e-04	15	47	2	GO:0017081
GeneOntologyMolecularFunction	adenylate cyclase binding	CHRFAM7A CHRNA7	6.37e-04	16	47	2	GO:0008179
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRFAM7A CHRNA7	7.21e-04	17	47	2	GO:0022848
GeneOntologyMolecularFunction	toxic substance binding	CHRFAM7A CHRNA7	8.10e-04	18	47	2	GO:0015643
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRFAM7A CHRNA7	1.33e-03	23	47	2	GO:0015464
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	4.45e-06	2	44	2	GO:0001988
GeneOntologyBiologicalProcess	baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	1.33e-05	3	44	2	GO:0001982
GeneOntologyBiologicalProcess	generation of ovulation cycle rhythm	CHRFAM7A CHRNA7	2.66e-05	4	44	2	GO:0060112
GeneOntologyBiologicalProcess	sensory processing	CHRFAM7A CHRNA7	4.43e-05	5	44	2	GO:0050893
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback	CHRFAM7A CHRNA7	6.64e-05	6	44	2	GO:0001978
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by baroreceptor feedback	CHRFAM7A CHRNA7	1.24e-04	8	44	2	GO:0003025
GeneOntologyBiologicalProcess	positive regulation of CoA-transferase activity	CHRFAM7A CHRNA7	1.59e-04	9	44	2	GO:1905920
GeneOntologyBiologicalProcess	regulation of CoA-transferase activity	CHRFAM7A CHRNA7	2.42e-04	11	44	2	GO:1905918
GeneOntologyBiologicalProcess	behavioral response to nicotine	CHRFAM7A CHRNA7	2.42e-04	11	44	2	GO:0035095
GeneOntologyBiologicalProcess	positive regulation of blood pressure	OR51E2 CHRFAM7A CHRNA7	2.71e-04	59	44	3	GO:0045777
GeneOntologyBiologicalProcess	regulation of synapse structural plasticity	CHRFAM7A CHRNA7	2.90e-04	12	44	2	GO:0051823
GeneOntologyBiologicalProcess	regulation of synaptic transmission, dopaminergic	CHRFAM7A CHRNA7	3.42e-04	13	44	2	GO:0032225
GeneOntologyBiologicalProcess	brain development	HIF1A C2CD3 KIF1A HYDIN VPS13B SMAD1 KDM4B APAF1	4.09e-04	859	44	8	GO:0007420
GeneOntologyBiologicalProcess	dendrite arborization	CHRFAM7A CHRNA7	4.59e-04	15	44	2	GO:0140059
GeneOntologyCellularComponent	spine apparatus membrane	CHRFAM7A CHRNA7	1.48e-05	3	47	2	GO:0098897
GeneOntologyCellularComponent	spine apparatus	CHRFAM7A CHRNA7	1.76e-04	9	47	2	GO:0097444
GeneOntologyCellularComponent	protein phosphatase type 2A complex	PPP2R2B PPP2R3A	7.40e-04	18	47	2	GO:0000159
GeneOntologyCellularComponent	acetylcholine-gated channel complex	CHRFAM7A CHRNA7	7.40e-04	18	47	2	GO:0005892
GeneOntologyCellularComponent	secretory granule membrane	CR1 KIF1A VPS13B GAA CD109	8.36e-04	329	47	5	GO:0030667
GeneOntologyCellularComponent	glycinergic synapse	CHRFAM7A CHRNA7	9.16e-04	20	47	2	GO:0098690
GeneOntologyCellularComponent	axolemma	CHRFAM7A CHRNA7	1.01e-03	21	47	2	GO:0030673
GeneOntologyCellularComponent	cholinergic synapse	CHRFAM7A CHRNA7	1.11e-03	22	47	2	GO:0098981
MousePheno	airway basal cell hyperplasia	CHRFAM7A CHRNA7	6.09e-06	2	35	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRFAM7A CHRNA7	6.09e-06	2	35	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRFAM7A CHRNA7	6.09e-06	2	35	2	MP:0011113
MousePheno	abnormal nicotine-mediated receptor currents	CHRFAM7A CHRNA7	3.64e-05	4	35	2	MP:0009475
MousePheno	failure of neuromuscular synapse presynaptic differentiation	CHRFAM7A CHRNA7	9.08e-05	6	35	2	MP:0001054
MousePheno	abnormal cerebral hemisphere morphology	ARFGEF2 CR1 CHRFAM7A LYST HYDIN CHRNA7 KDM4B APAF1	9.14e-05	599	35	8	MP:0008540
MousePheno	abnormal telencephalon morphology	OR51E2 ARFGEF2 CR1 CHRFAM7A LYST HYDIN CHRNA7 KDM4B APAF1	1.29e-04	812	35	9	MP:0000787
MousePheno	abnormal GABAergic neuron physiology	CHRFAM7A CHRNA7	1.69e-04	8	35	2	MP:0011987
MousePheno	abnormal cranial flexure morphology	C2CD3 APAF1	2.17e-04	9	35	2	MP:0004203
MousePheno	globular heart	CASZ1 GAA	3.30e-04	11	35	2	MP:0031511
MousePheno	impaired spatial working memory	CHRFAM7A CHRNA7	3.96e-04	12	35	2	MP:0014370
MousePheno	decreased erythroblast number	CHRFAM7A CHRNA7	3.96e-04	12	35	2	MP:0011179
Domain	KRAB	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 ZNF283	1.82e-04	358	44	6	PS50805
Domain	KRAB	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 ZNF283	1.82e-04	358	44	6	PF01352
Domain	zf-C2H2	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 CASZ1 ZNF687 ZNF283	1.87e-04	693	44	8	PF00096
Domain	KRAB	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 ZNF283	2.14e-04	369	44	6	SM00349
Domain	KRAB	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 ZNF283	2.17e-04	370	44	6	IPR001909
Domain	ZINC_FINGER_C2H2_2	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 CASZ1 ZNF687 ZNF283	3.99e-04	775	44	8	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 CASZ1 ZNF687 ZNF283	4.06e-04	777	44	8	PS00028
Domain	Znf_C2H2-like	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 CASZ1 ZNF687 ZNF283	4.76e-04	796	44	8	IPR015880
Domain	Znf_C2H2	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 CASZ1 ZNF687 ZNF283	5.13e-04	805	44	8	IPR007087
Domain	ZnF_C2H2	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 CASZ1 ZNF687 ZNF283	5.26e-04	808	44	8	SM00355
Domain	Znf_C2H2/integrase_DNA-bd	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 ZNF687 ZNF283	1.10e-03	694	44	7	IPR013087
Domain	-	CHRFAM7A CHRNA7	1.33e-03	23	44	2	1.20.120.370
Domain	Acetylcholine_rcpt_TM	CHRFAM7A CHRNA7	1.33e-03	23	44	2	IPR027361
Domain	PH_dom-like	PTPN14 AGAP7P KIF1A LYST ANKS1A	3.15e-03	426	44	5	IPR011993
Domain	-	HELZ DHX57	4.00e-03	40	44	2	4.10.1000.10
Domain	-	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 ZNF283	4.91e-03	679	44	6	3.30.160.60
Domain	Neurotransmitter_ion_chnl_CS	CHRFAM7A CHRNA7	5.04e-03	45	44	2	IPR018000
Domain	Neur_chan_memb	CHRFAM7A CHRNA7	5.26e-03	46	44	2	PF02932
Domain	Neur_chan_LBD	CHRFAM7A CHRNA7	5.48e-03	47	44	2	PF02931
Domain	NEUROTR_ION_CHANNEL	CHRFAM7A CHRNA7	5.48e-03	47	44	2	PS00236
Domain	Neurotrans-gated_channel_TM	CHRFAM7A CHRNA7	5.48e-03	47	44	2	IPR006029
Domain	-	CHRFAM7A CHRNA7	5.48e-03	47	44	2	2.70.170.10
Domain	Neur_channel	CHRFAM7A CHRNA7	5.48e-03	47	44	2	IPR006201
Domain	Neur_chan_lig-bd	CHRFAM7A CHRNA7	5.48e-03	47	44	2	IPR006202
Domain	ZnF_C3H1	HELZ DHX57	5.71e-03	48	44	2	SM00356
Domain	zf-CCCH	HELZ DHX57	5.95e-03	49	44	2	PF00642
Domain	zf-C2H2_6	ZNF420 ZNF527 ZNF878 ZNF283	6.27e-03	314	44	4	PF13912
Domain	SMAD_FHA_domain	KIF1A SMAD1	6.67e-03	52	44	2	IPR008984
Domain	WD40_repeat_CS	PPP2R2B LYST APAF1	6.76e-03	164	44	3	IPR019775
Domain	CCP	SNED1 CR1	7.18e-03	54	44	2	SM00032
Domain	SUSHI	SNED1 CR1	7.71e-03	56	44	2	PS50923
Domain	Sushi_SCR_CCP_dom	SNED1 CR1	7.97e-03	57	44	2	IPR000436
Domain	Znf_CCCH	HELZ DHX57	8.25e-03	58	44	2	IPR000571
Domain	ZF_C3H1	HELZ DHX57	8.25e-03	58	44	2	PS50103
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	38070724
Pubmed	Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19626424
Pubmed	Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17012698
Pubmed	Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	26451017
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	34453977
Pubmed	Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotype.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24757672
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	26999808
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	27129924
Pubmed	Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17291692
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19344760
Pubmed	Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	35926661
Pubmed	The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17640819
Pubmed	Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23431157
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	29114104
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	32552811
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24836856
Pubmed	Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	31904546
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	35678315
Pubmed	Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33117372
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	12628457
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	25157794
Pubmed	Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19615981
Pubmed	Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	38944290
Pubmed	Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	28243714
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22246862
Pubmed	Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24298024
Pubmed	Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	29975102
Pubmed	α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	29580318
Pubmed	Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	35479080
Pubmed	[Activation of α7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice].	CHRFAM7A CHRNA7	1.79e-06	2	47	2	38597441
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	27471776
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22688057
Pubmed	α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22820264
Pubmed	Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33953172
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	32028688
Pubmed	Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	30089821
Pubmed	Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	20615555
Pubmed	Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15896732
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	21501254
Pubmed	α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	21339364
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	21368056
Pubmed	Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24289814
Pubmed	Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19949071
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	1400473
Pubmed	Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17204496
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	26937017
Pubmed	α7 nicotinic receptors play a role in regulation of cardiac hemodynamics.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	37017608
Pubmed	Impaired hippocampal theta oscillations in the mice null alpha7 nicotinic acetylcholine receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23795917
Pubmed	Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	36603528
Pubmed	Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	20592195
Pubmed	Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	26650489
Pubmed	Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	11854451
Pubmed	Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22848433
Pubmed	Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23842742
Pubmed	Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17292512
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	16650968
Pubmed	Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	35413868
Pubmed	Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23637989
Pubmed	Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7).	CHRFAM7A CHRNA7	1.79e-06	2	47	2	9782083
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	29261717
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	18199426
Pubmed	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22490926
Pubmed	Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	36997969
Pubmed	A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15364017
Pubmed	Choline, an alpha7 nicotinic acetylcholine receptor agonist, alleviates hyperalgesia in a rat osteoarthritis model.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23769729
Pubmed	Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15944242
Pubmed	Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23270857
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	18077004
Pubmed	HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism.	HIF1A KDM4B	1.79e-06	2	47	2	22745382
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19462340
Pubmed	Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	16923147
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	11790782
Pubmed	A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33422641
Pubmed	Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	30270436
Pubmed	Activation of α-7 Nicotinic Acetylcholine Receptor Attenuates Cardiac Inflammation Through NLRP3/Caspase-1/IL-18 Pathway.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	34988776
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	37746145
Pubmed	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19631623
Pubmed	Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15770102
Pubmed	Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	24326163
Pubmed	Association of JMJD2B and Hypoxia-Inducible Factor 1 Expressions with Poor Prognosis in Osteosarcoma.	HIF1A KDM4B	1.79e-06	2	47	2	32802732
Pubmed	Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33398432
Pubmed	Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23811428
Pubmed	beta-Amyloid activates presynaptic alpha7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	20374280
Pubmed	Proteome profile of the cerebellum from α7 nicotinic acetylcholine receptor deficient mice.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	38185761
Pubmed	Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	20720594
Pubmed	α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	22624500
Pubmed	Involvement of acetylcholine-α7nAChR in the protective effects of arterial baroreflex against ischemic stroke.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	23106973
Pubmed	Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	33902624
Pubmed	Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	17019565
Pubmed	Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha7 nicotinic ACh receptors.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	19100751
Pubmed	Identification of an alternatively processed nicotinic receptor alpha7 subunit RNA in mouse brain.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	14499477
Pubmed	Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	15969741
Pubmed	Activation of the α7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells.	CHRFAM7A CHRNA7	1.79e-06	2	47	2	35883638
GeneFamily	Olfactory receptors, family 51	OR51E2 OR51D1 OR51H1	1.16e-04	44	39	3	164
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R2B PPP2R3A	4.68e-04	15	39	2	696
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF420 ZNF81 ZNF527 ZNF878 ZNF45 CASZ1 ZNF283	7.67e-04	718	39	7	28
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PPP2R3A ZNF81 PTPN14 VPS13B SMAD1	9.51e-07	169	47	5	d2def7229fe9d6b0c70cfed349ede491c8c137a0
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	PPP2R3A ZNF81 PTPN14 SMAD1	2.95e-05	168	47	4	d7d19c93d1c3dd994e18e28d5f36ae7773ff5d7f
ToppCell	T_cells-Tph_and_Tfh\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	HIF1A PTPN14 LYST CD109	3.54e-05	176	47	4	56c055488e34605d32562571a2fee621b47c9441
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-2\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PHOSPHO2 RNASE6 CR1 CASZ1	3.95e-05	181	47	4	75035a3211e524bb659b82e6979f7d3a3121ae70
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HIF1A PPP2R3A PTPN14 HYDIN	4.48e-05	187	47	4	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SNED1 LYPD6B PTPN14 CD109	5.07e-05	193	47	4	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SCNN1A PPP2R3A HYDIN CASZ1	5.17e-05	194	47	4	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SCNN1A PPP2R3A PTPN14 CASZ1	5.27e-05	195	47	4	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SCNN1A PPP2R3A HYDIN CASZ1	5.38e-05	196	47	4	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SCNN1A LYPD6B PPP2R2B PPP2R3A	5.38e-05	196	47	4	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF420 PTPN14 GAA SMAD1	5.49e-05	197	47	4	789c97ca9d1e28df3353140046047f11fbccc1d0
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPN14 CCDC102B SMAD1 ANKS1A	5.60e-05	198	47	4	5d42f4fda2081ea3e9f62a00e7eea702e0d0be7d
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HIF1A RNASE6 CR1 GAA	5.60e-05	198	47	4	eb0a94c426a7c567f94490b848e28784587c6dcd
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPN14 CCDC102B SMAD1 ANKS1A	5.60e-05	198	47	4	99d6a64f3410dae3019161feef20a8f06081a24b
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HIF1A CR1 LYST CD109	5.60e-05	198	47	4	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	mild-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HIF1A RNASE6 CR1 GAA	5.71e-05	199	47	4	d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SH3TC1 AP5B1 GAA CD109	5.82e-05	200	47	4	88d713dfc792e7609bf7ecfb28f87cb748088570
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HIF1A RNASE6 CR1 GAA	5.82e-05	200	47	4	2cca77b2c9d829daa674a844e068f2b083e90d6e
ToppCell	control-HLA-DR-_S100A+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CR1 LYST GAA APAF1	5.82e-05	200	47	4	9e3e13a68bc1110fa000ec2d80f4c654ddbce17e
Computational	Genes in the cancer module 67.	PPP2R3A NOL9 CHRFAM7A HYDIN AP5B1	2.22e-04	227	27	5	MODULE_67
Disease	cognitive disorder (implicated_via_orthology)	CHRFAM7A CHRNA7	3.40e-05	6	45	2	DOID:1561 (implicated_via_orthology)
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRFAM7A CHRNA7	3.40e-05	6	45	2	DOID:7148 (biomarker_via_orthology)
Disease	nicotine dependence (implicated_via_orthology)	CHRFAM7A CHRNA7	1.49e-04	12	45	2	DOID:0050742 (implicated_via_orthology)
Disease	cytotoxicity measurement, response to metformin	KIF1A SH3TC1	4.69e-04	21	45	2	EFO_0006952, GO_1901558
Disease	age of onset of Alzheimer disease	ARFGEF2 CR1	1.17e-03	33	45	2	OBA_2001000
Disease	Paroxysmal atrial fibrillation	PPP2R3A LRIG1 CASZ1	1.75e-03	156	45	3	C0235480
Disease	familial atrial fibrillation	PPP2R3A LRIG1 CASZ1	1.75e-03	156	45	3	C3468561
Disease	Persistent atrial fibrillation	PPP2R3A LRIG1 CASZ1	1.75e-03	156	45	3	C2585653
Disease	Atrial Fibrillation	PPP2R3A LRIG1 CASZ1	1.88e-03	160	45	3	C0004238
Disease	Alzheimer disease, polygenic risk score	PPP2R3A CR1 ZNF45 HYDIN KDM4B	1.93e-03	586	45	5	EFO_0030082, MONDO_0004975
Disease	myocardial infarction	PPP2R3A CCDC102B GAA CD109	1.98e-03	350	45	4	EFO_0000612
Disease	susceptibility to chickenpox measurement	PPP2R2B CCDC102B	2.35e-03	47	45	2	EFO_0008400

Protein segments in the cluster

Peptide	Gene	Start	Entry
HTGHHSTIQYCDFSP	APAF1	836	O14727
HPHHCNTFVYSSSKG	PPP2R2B	231	Q00005
SVYYHGCHLNGKSTH	CASZ1	536	Q86V15
DHFTLQHTHINGVTC	ADAM21	576	Q9UKJ8
QTTCHIVTTIFQHHF	ARFGEF2	1246	Q9Y6D5
TSHHYCHVFSTVDVN	ANKS1A	1031	Q92625
FHTNVLVNSSGHCQY	CHRNA7	126	P36544
TNYSFHCNVCHHSGN	ASH2L	141	Q9UBL3
HCNVCHHSGNTYFLR	ASH2L	146	Q9UBL3
FSVYTHSCLSIHALH	NOL9	166	Q5SY16
QCVITNHFGSTYSHK	LRIG1	576	Q96JA1
VLHCTGHIHVYDTNS	HIF1A	191	Q16665
QPVQSSHCHHFQSSS	C9orf131	856	Q5VYM1
YCQTHTVTHSFCLHQ	OR51D1	181	Q8NGF3
AFCHSNVLSHSYCVH	OR51E2	166	Q9H255
CHSNVLSHSYCLHQN	OR51H1	171	Q8NH63
YEHCSTSFHVTCAHA	KDM4B	871	O94953
HALYTTSTGLTCHAH	AP5B1	741	Q2VPB7
VHQYCLISSAHSTFQ	HELZ	741	P42694
QAIHYCTGTCHTFTH	PPP2R3A	26	Q06190
NGHLTVENYHTHSCN	PHOSPHO2	131	Q8TCD6
FHTNVLVNSSGHCQY	CHRFAM7A	36	Q494W8
SGSHHHSSVIFIFCF	CD109	1421	Q6YHK3
CHIGHSYNASFTVTN	HYDIN	3661	Q4G0P3
FSHHVEFTCNLVTQH	C2CD3	1261	Q4AC94
TSFHNGTVVTYQCHT	CR1	1536	P17927
GVCFHLFTSHHYNHQ	DHX57	971	Q6P158
CTNHVSTVHFSQQYS	AGAP7P	106	Q5VUJ5
SVHVGTSFHHQQAYS	LYST	851	Q99698
TICASSHQFLSTHYN	GAA	556	P10253
QVSCNQANYSHFHHP	SCNN1A	286	P37088
SHAAHNFCAHSYNTN	CCDC102B	51	Q68D86
HTFNREYTHSHVCVS	KIF1A	1461	Q12756
CHTSSTQSHCYQTIH	PCARE	151	A6NGG8
HVQCGEHYSETHTSQ	PTPN14	341	Q15678
TYHALGFTHHCLANL	SH3TC1	156	Q8TE82
YTQHCKHQNTFLHDS	RNASE6	56	Q93091
SYLCVCHTDHNASHS	SNED1	526	Q8TER0
QSRNCNYHHGFHPTT	SMAD1	356	Q15797
PTQYSSFSCHHFSNH	SPEM2	101	Q0P670
SFSCHHFSNHHSSSL	SPEM2	106	Q0P670
SECSIHHELYHQISS	VPS13B	3286	Q7Z7G8
NQHTYLSQHSRCHST	ZNF420	121	Q8TAQ5
SAHAHLYSQHPSFQT	ZNF687	806	Q8N1G0
FSYSSHLNIHCRIHT	ZNF45	341	Q02386
VFTQNSSYSHHENTH	ZNF81	226	P51508
QCGKTFTSSNSFHYH	ZNF878	371	C9JN71
FCSGYQLTRHQVFHT	ZNF283	496	Q8N7M2
SFHSLFTQHQTTHFG	ZNF527	256	Q8NB42
NTQYCLTVHHFTSHG	LYPD6B	86	Q8NI32