Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1C CACNA1D CACNA1F	3.21e-05	14	91	3	GO:0008331
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1C CACNA1D	2.04e-04	5	91	2	GO:0086007
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	PMS2 MLH3 ERCC3 ZGRF1 UPF1	2.89e-04	127	91	5	GO:0008094
GeneOntologyCellularComponent	RAVE complex	DMXL2 DMXL1	5.73e-05	3	92	2	GO:0043291
GeneOntologyCellularComponent	piP-body	TDRKH TDRD9	1.90e-04	5	92	2	GO:0071547
MousePheno	male infertility	ADCY10 TDRKH NEK1 WWC2 CDS1 PMS2 MLH3 TDRD9 TLE4 TTC21A ZC3HC1 WSB2 RORB HERC2 PACRG TBC1D21	1.55e-05	944	71	16	MP:0001925
MousePheno	abnormal male reproductive system physiology	ADCY10 EPHB6 TDRKH NEK1 WWC2 CDS1 PMS2 MLH3 TDRD9 TLE4 TTC21A ROR2 ZC3HC1 WSB2 RORB HERC2 PACRG TBC1D21 WDR48	2.36e-05	1329	71	19	MP:0003698
Domain	CAC1F_C	CACNA1C CACNA1D CACNA1F	1.05e-07	3	89	3	IPR031688
Domain	CAC1F_C	CACNA1C CACNA1D CACNA1F	1.05e-07	3	89	3	PF16885
Domain	VDCC_L_a1su	CACNA1C CACNA1D CACNA1F	4.17e-07	4	89	3	IPR005446
Domain	VDCC_a1su_IQ	CACNA1C CACNA1D CACNA1F	3.61e-06	7	89	3	IPR014873
Domain	GPHH	CACNA1C CACNA1D CACNA1F	3.61e-06	7	89	3	PF16905
Domain	GPHH_dom	CACNA1C CACNA1D CACNA1F	3.61e-06	7	89	3	IPR031649
Domain	Ca_chan_IQ	CACNA1C CACNA1D CACNA1F	3.61e-06	7	89	3	SM01062
Domain	Ca_chan_IQ	CACNA1C CACNA1D CACNA1F	3.61e-06	7	89	3	PF08763
Domain	VDCCAlpha1	CACNA1C CACNA1D CACNA1F	1.23e-05	10	89	3	IPR002077
Domain	Rav1p_C	DMXL2 DMXL1	2.25e-05	2	89	2	IPR022033
Domain	MutL_C	PMS2 MLH3	2.25e-05	2	89	2	PF08676
Domain	Cell_morpho_N	FRY FRYL	2.25e-05	2	89	2	IPR025614
Domain	MutL_C	PMS2 MLH3	2.25e-05	2	89	2	SM00853
Domain	MOR2-PAG1_mid	FRY FRYL	2.25e-05	2	89	2	IPR029473
Domain	MOR2-PAG1_mid	FRY FRYL	2.25e-05	2	89	2	PF14228
Domain	MOR2-PAG1_C	FRY FRYL	2.25e-05	2	89	2	PF14225
Domain	MOR2-PAG1_N	FRY FRYL	2.25e-05	2	89	2	PF14222
Domain	Rav1p_C	DMXL2 DMXL1	2.25e-05	2	89	2	PF12234
Domain	Cell_Morphogen_C	FRY FRYL	2.25e-05	2	89	2	IPR025481
Domain	MutL_C	PMS2 MLH3	2.25e-05	2	89	2	IPR014790
Domain	Aldolase_II/adducin_N	ADD2 ADD3	1.34e-04	4	89	2	IPR001303
Domain	DNA_mismatch_repair_C	PMS2 MLH3	1.34e-04	4	89	2	IPR013507
Domain	Aldolase_II	ADD2 ADD3	1.34e-04	4	89	2	PF00596
Domain	DNA_mismatch_repair_fam	PMS2 MLH3	1.34e-04	4	89	2	IPR002099
Domain	DNA_mis_repair	PMS2 MLH3	1.34e-04	4	89	2	PF01119
Domain	-	ADD2 ADD3	1.34e-04	4	89	2	3.40.225.10
Domain	CLASP_N	TOGARAM2 CLASP2	1.34e-04	4	89	2	PF12348
Domain	CLASP_N_dom	TOGARAM2 CLASP2	1.34e-04	4	89	2	IPR024395
Domain	Aldolase_II	ADD2 ADD3	1.34e-04	4	89	2	SM01007
Domain	DNA_MISMATCH_REPAIR_1	PMS2 MLH3	1.34e-04	4	89	2	PS00058
Domain	ARM-type_fold	AP2A2 DOCK9 USP24 TOGARAM2 CLASP2 FRYL TANGO6 ITPR1	2.14e-04	339	89	8	IPR016024
Domain	DNA_mismatch_repair_CS	PMS2 MLH3	2.22e-04	5	89	2	IPR014762
Domain	WD40_repeat	DMXL2 RRP9 TLE4 WSB2 HERC2 DMXL1 WDR48	3.20e-04	272	89	7	IPR001680
Domain	WD_REPEATS_1	DMXL2 RRP9 TLE4 WSB2 HERC2 DMXL1 WDR48	3.65e-04	278	89	7	PS00678
Domain	WD_REPEATS_2	DMXL2 RRP9 TLE4 WSB2 HERC2 DMXL1 WDR48	3.73e-04	279	89	7	PS50082
Domain	WD_REPEATS_REGION	DMXL2 RRP9 TLE4 WSB2 HERC2 DMXL1 WDR48	3.73e-04	279	89	7	PS50294
Domain	ResIII	ERCC3 UPF1	6.17e-04	8	89	2	PF04851
Domain	Helicase/UvrB_N	ERCC3 UPF1	6.17e-04	8	89	2	IPR006935
Domain	LAM_G_DOMAIN	FAT2 CELSR3 FAT3	7.82e-04	38	89	3	PS50025
Domain	Laminin_G_2	FAT2 CELSR3 FAT3	9.10e-04	40	89	3	PF02210
Domain	MIR	POMT2 ITPR1	9.86e-04	10	89	2	PS50919
Domain	MIR	POMT2 ITPR1	9.86e-04	10	89	2	PF02815
Domain	MIR	POMT2 ITPR1	9.86e-04	10	89	2	SM00472
Domain	MIR_motif	POMT2 ITPR1	9.86e-04	10	89	2	IPR016093
Domain	LamG	FAT2 CELSR3 FAT3	1.20e-03	44	89	3	SM00282
Domain	WD40	DMXL2 RRP9 TLE4 WSB2 DMXL1 WDR48	1.49e-03	259	89	6	PF00400
Domain	WD40	DMXL2 RRP9 TLE4 WSB2 DMXL1 WDR48	1.77e-03	268	89	6	SM00320
Domain	Ubiquitin-rel_dom	ARAP3 FRMPD2 USP24 PPP1R13B TP53BP2	1.87e-03	184	89	5	IPR029071
Domain	TUDOR	TDRKH TDRD9	1.97e-03	14	89	2	PF00567
Domain	Ion_trans_dom	CACNA1C CACNA1D CACNA1F ITPR1	2.16e-03	114	89	4	IPR005821
Domain	Ion_trans	CACNA1C CACNA1D CACNA1F ITPR1	2.16e-03	114	89	4	PF00520
Domain	Channel_four-helix_dom	CACNA1C CACNA1D CACNA1F	2.54e-03	57	89	3	IPR027359
Domain	-	CACNA1C CACNA1D CACNA1F	2.54e-03	57	89	3	1.20.120.350
Domain	Laminin_G	FAT2 CELSR3 FAT3	2.67e-03	58	89	3	IPR001791
Domain	EGF_CA	FAT2 FBN2 CELSR3 FAT3	2.76e-03	122	89	4	SM00179
Domain	EGF-like_Ca-bd_dom	FAT2 FBN2 CELSR3 FAT3	2.93e-03	124	89	4	IPR001881
Domain	WD40_repeat_dom	DMXL2 RRP9 TLE4 WSB2 DMXL1 WDR48	2.96e-03	297	89	6	IPR017986
Domain	HA2	TDRD9 DHX32	3.27e-03	18	89	2	SM00847
Domain	HA2	TDRD9 DHX32	3.27e-03	18	89	2	PF04408
Domain	Helicase-assoc_dom	TDRD9 DHX32	3.27e-03	18	89	2	IPR007502
Domain	HATPase_c	PMS2 MLH3	3.27e-03	18	89	2	SM00387
Domain	HATPase_c	PMS2 MLH3	3.64e-03	19	89	2	PF02518
Domain	-	AP2A2 TOGARAM2 CLASP2 FRYL TANGO6	4.19e-03	222	89	5	1.25.10.10
Domain	HATPase_C	PMS2 MLH3	4.45e-03	21	89	2	IPR003594
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1D CACNA1F	2.12e-06	6	68	3	M47762
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004	CACNA1C CACNA1D CACNA1F	3.76e-05	14	68	3	M47692
Pathway	WP_MALE_INFERTILITY	LIG4 PMS2 MLH3 CDC42BPA PACRG SIRPG	6.92e-05	145	68	6	M39856
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1D CACNA1F	1.77e-04	23	68	3	M47666
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1C CACNA1D CACNA1F	2.29e-04	25	68	3	M47948
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	CACNA1C CACNA1D CACNA1F MYLK2 ITPR1	2.29e-04	115	68	5	M9387
Pathway	WP_ALZHEIMERS_DISEASE	CACNA1C CACNA1D CACNA1F ITPR1	4.42e-04	74	68	4	MM15962
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	CACNA1C CACNA1D AHCYL1 ITPR1	5.40e-04	78	68	4	M1921
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1C CACNA1D CACNA1F	7.39e-08	4	93	3	20937870
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1D CACNA1F	6.43e-07	7	93	3	12900400
Pubmed	NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.	CACNA1C CACNA1D CACNA1F	3.01e-06	11	93	3	18809727
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1C CACNA1D CACNA1F ITPR1	3.30e-06	38	93	4	30786075
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	WWC2 PMS2 CAD CDC42BPA PPP1R13B BRCC3 CLASP2 HERC2 CEMIP2 ADD2 TP53BP2 ITPR1 WDR48	4.43e-06	1049	93	13	27880917
Pubmed	Binding of IRBIT to the IP3 receptor: determinants and functional effects.	AHCYL1 ITPR1	7.07e-06	2	93	2	16527252
Pubmed	IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor.	AHCYL1 ITPR1	7.07e-06	2	93	2	12525476
Pubmed	Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.	CACNA1C CACNA1D	7.07e-06	2	93	2	20014384
Pubmed	Expression of adducin genes during erythropoiesis: a novel erythroid promoter for ADD2.	ADD2 ADD3	7.07e-06	2	93	2	15963851
Pubmed	Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels.	CACNA1C CACNA1D	7.07e-06	2	93	2	30001160
Pubmed	Rescue and worsening of congenital heart block-associated electrocardiographic abnormalities in two transgenic mice.	CACNA1C CACNA1D	7.07e-06	2	93	2	21352396
Pubmed	Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53.	PPP1R13B TP53BP2	7.07e-06	2	93	2	15757645
Pubmed	Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells.	CACNA1C CACNA1D	7.07e-06	2	93	2	21054386
Pubmed	Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.	CACNA1C CACNA1D	7.07e-06	2	93	2	17409250
Pubmed	Neuronal L-type calcium channels open quickly and are inhibited slowly.	CACNA1C CACNA1D	7.07e-06	2	93	2	16267232
Pubmed	Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination.	PMS2 MLH3	7.07e-06	2	93	2	33453991
Pubmed	The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function.	CACNA1C CACNA1D	7.07e-06	2	93	2	24996399
Pubmed	Targeted deletion of the gamma-adducin gene (Add3) in mice reveals differences in alpha-adducin interactions in erythroid and nonerythroid cells.	ADD2 ADD3	7.07e-06	2	93	2	19425068
Pubmed	Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.	CACNA1D CACNA1F	7.07e-06	2	93	2	25966695
Pubmed	ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair.	ERCC3 ELL	7.07e-06	2	93	2	24127601
Pubmed	IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor.	AHCYL1 ITPR1	7.07e-06	2	93	2	16793548
Pubmed	An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.	CACNA1C CACNA1D	7.07e-06	2	93	2	24086669
Pubmed	Apoptosis stimulating protein of p53 (ASPP) 1 and ASPP2 m-RNA expression in oral cancer.	PPP1R13B TP53BP2	7.07e-06	2	93	2	32987288
Pubmed	Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.	CACNA1C CACNA1D	7.07e-06	2	93	2	24849370
Pubmed	Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3.	CACNA1C CACNA1D	7.07e-06	2	93	2	26049024
Pubmed	Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fear.	CACNA1C CACNA1D	7.07e-06	2	93	2	17015854
Pubmed	A conserved sequence in the T-cell receptor beta-chain promoter region.	TRBV12-4 TRBV12-3	7.07e-06	2	93	2	3259318
Pubmed	The T cell receptor from an influenza-A specific murine CTL clone.	TRBV12-4 TRBV12-3	7.07e-06	2	93	2	2784852
Pubmed	[Promoter methylation of ASPP1 and ASPP2 genes in non-small cell lung cancers].	PPP1R13B TP53BP2	7.07e-06	2	93	2	22169642
Pubmed	Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.	CACNA1C CACNA1D	7.07e-06	2	93	2	19225208
Pubmed	Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB.	CACNA1C CACNA1D	7.07e-06	2	93	2	16706838
Pubmed	Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.	CACNA1C CACNA1D	7.07e-06	2	93	2	23761887
Pubmed	Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.	CACNA1C CACNA1D	7.07e-06	2	93	2	14981074
Pubmed	CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.	CACNA1C CACNA1D	7.07e-06	2	93	2	25292336
Pubmed	Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma.	PPP1R13B TP53BP2	7.07e-06	2	93	2	20034025
Pubmed	Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.	CACNA1C CACNA1D	7.07e-06	2	93	2	17526649
Pubmed	ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells.	PPP1R13B TP53BP2	7.07e-06	2	93	2	23392125
Pubmed	Ligand-activated signal transduction in the 2-cell embryo.	CACNA1C CACNA1D	7.07e-06	2	93	2	12606379
Pubmed	Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.	CACNA1C CACNA1D	7.07e-06	2	93	2	24941892
Pubmed	Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.	CACNA1C CACNA1D	7.07e-06	2	93	2	24848473
Pubmed	Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells.	CACNA1C CACNA1D	7.07e-06	2	93	2	22826131
Pubmed	C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.	CACNA1D CACNA1F	7.07e-06	2	93	2	16921373
Pubmed	Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.	CACNA1C CACNA1D	7.07e-06	2	93	2	24470632
Pubmed	Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor.	AHCYL1 ITPR1	7.07e-06	2	93	2	17635105
Pubmed	ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.	PPP1R13B TP53BP2	7.07e-06	2	93	2	26595804
Pubmed	Interaction between superantigen and T-cell receptor Vbeta element determines levels of superantigen-dependent cell-mediated cytotoxicity of CD8(+) T cells in induction and effector phases.	TRBV12-4 TRBV12-3	7.07e-06	2	93	2	19659929
Pubmed	Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.	CACNA1C CACNA1D	7.07e-06	2	93	2	24760982
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1C CACNA1D CACNA1F	8.23e-06	15	93	3	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1C CACNA1D CACNA1F	8.23e-06	15	93	3	24453333
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	LIFR DMXL2 AHCYL1 CAD CDC42BPA RRP9 ROR2 CLASP2 UPF1 HERC2 CEMIP2 ADD2 ADD3 DMXL1 ITPR1	9.21e-06	1487	93	15	33957083
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NEK1 CAD TCF20 USP24 PPP1R13B UPF1 RSBN1L TP53BP2 ADD3	1.69e-05	549	93	9	38280479
Pubmed	The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts.	CACNA1C CACNA1D	2.12e-05	3	93	2	19351867
Pubmed	Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth.	CACNA1C CACNA1D	2.12e-05	3	93	2	21832054
Pubmed	IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.	AHCYL1 ITPR1	2.12e-05	3	93	2	27995898
Pubmed	Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans.	ADD2 ADD3	2.12e-05	3	93	2	15834281
Pubmed	Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels.	CACNA1C CACNA1D	2.12e-05	3	93	2	17289261
Pubmed	ASPP: a new family of oncogenes and tumour suppressor genes.	PPP1R13B TP53BP2	2.12e-05	3	93	2	17211478
Pubmed	Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failure.	CACNA1C CACNA1D	2.12e-05	3	93	2	23973784
Pubmed	Analysis of the T cell receptor (TcR) regions in the NOD, NON and CTS mouse strains define new TcR V alpha haplotypes and new deletions in the TcR V beta region.	TRBV12-4 TRBV12-3	2.12e-05	3	93	2	1532150
Pubmed	ASPP--Apoptotic specific regulator of p53.	PPP1R13B TP53BP2	2.12e-05	3	93	2	16139958
Pubmed	Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP.	PPP1R13B TP53BP2	2.12e-05	3	93	2	22552744
Pubmed	Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice.	ADD2 ADD3	2.12e-05	3	93	2	10485892
Pubmed	miR-23a promotes the transition from indolent to invasive colorectal cancer.	PMS2 MLH3	2.12e-05	3	93	2	22628407
Pubmed	Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP).	CACNA1C CACNA1D	2.12e-05	3	93	2	17767505
Pubmed	Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.	FAT2 FAT3	2.12e-05	3	93	2	15744052
Pubmed	MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Cav1.2 and Cav1.3 ion channels.	CACNA1C CACNA1D	2.12e-05	3	93	2	31302118
Pubmed	Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node.	CACNA1C CACNA1D	2.12e-05	3	93	2	23045342
Pubmed	Role of the adducin family genes in human essential hypertension.	ADD2 ADD3	2.12e-05	3	93	2	15716695
Pubmed	Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.	CACNA1C CACNA1D	2.12e-05	3	93	2	2173707
Pubmed	Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.	CACNA1C CACNA1D	2.12e-05	3	93	2	24934288
Pubmed	Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability.	PPP1R13B TP53BP2	2.12e-05	3	93	2	23644657
Pubmed	Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.	PMS2 MLH3	2.12e-05	3	93	2	16204034
Pubmed	TRPV6 and Cav1.3 Mediate Distal Small Intestine Calcium Absorption Before Weaning.	EPHB6 CACNA1D	2.12e-05	3	93	2	31398491
Pubmed	FEZ1 interacts with CLASP2 and NEK1 through coiled-coil regions and their cellular colocalization suggests centrosomal functions and regulation by PKC.	NEK1 CLASP2	2.12e-05	3	93	2	19924516
Pubmed	Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Ménière's syndrome.	ADD2 ADD3	2.12e-05	3	93	2	18667944
Pubmed	G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.	CACNA1C CACNA1D	2.12e-05	3	93	2	26831068
Pubmed	Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes.	ADD2 ADD3	2.12e-05	3	93	2	1864459
Pubmed	Arterial properties in relation to genetic variations in the adducin subunits in a white population.	ADD2 ADD3	2.12e-05	3	93	2	18787518
Pubmed	T cell receptor genes in an alloreactive CTL clone: implications for rearrangement and germline diversity of variable gene segments.	TRBV12-4 TRBV12-3	2.12e-05	3	93	2	3490968
Pubmed	ASPP1 and ASPP2 are new transcriptional targets of E2F.	PPP1R13B TP53BP2	2.12e-05	3	93	2	15731768
Pubmed	The tumor suppressor proteins ASPP1 and ASPP2 interact with C-Nap1 and regulate centrosome linker reassembly.	PPP1R13B TP53BP2	2.12e-05	3	93	2	25660448
Pubmed	Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.	CACNA1C CACNA1D	2.12e-05	3	93	2	23338940
Pubmed	An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage.	AHCYL1 ITPR1	2.12e-05	3	93	2	19220705
Pubmed	Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study.	PPP1R13B TP53BP2	2.12e-05	3	93	2	28103919
Pubmed	Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.	CACNA1D CACNA1F	2.12e-05	3	93	2	26024096
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	CACNA1D CDC42BPA DOCK9 CLASP2 ITPR1	2.50e-05	128	93	5	30995482
Pubmed	Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.	LIG4 PMS2 MLH3 ERCC3	3.42e-05	68	93	4	20496165
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	MCTS2 FRY USP24 CLASP2 UPF1 HERC2 DMXL1 ITPR1	4.21e-05	475	93	8	31040226
Pubmed	Tandem linkage and unusual RNA splicing of the T-cell receptor beta-chain variable-region genes.	TRBV12-4 TRBV12-3	4.23e-05	4	93	2	3470773
Pubmed	Two cellular proteins that bind to wild-type but not mutant p53.	ELL TP53BP2	4.23e-05	4	93	2	8016121
Pubmed	An intact Pms2 ATPase domain is not essential for male fertility.	PMS2 MLH3	4.23e-05	4	93	2	26753533
Pubmed	Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2.	CACNA1C CACNA1D	4.23e-05	4	93	2	17110593
Pubmed	beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits.	ADD2 ADD3	4.23e-05	4	93	2	19900187
Pubmed	Screening methylation of DNA repair genes in the oral mucosa of chronic smokers.	PMS2 MLH3	4.23e-05	4	93	2	29775861
Pubmed	ASPP1 and ASPP2: common activators of p53 family members.	PPP1R13B TP53BP2	4.23e-05	4	93	2	14729977
Pubmed	ASPP proteins specifically stimulate the apoptotic function of p53.	PPP1R13B TP53BP2	4.23e-05	4	93	2	11684014
Pubmed	Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.	PMS2 MLH3	4.23e-05	4	93	2	18551179
Pubmed	The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2.	PMS2 MLH3	4.23e-05	4	93	2	11292842
Pubmed	Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.	AHCYL1 ITPR1	4.23e-05	4	93	2	23542070
Pubmed	Murine T-cell receptor mutants with deletions of beta-chain variable region genes.	TRBV12-4 TRBV12-3	4.23e-05	4	93	2	3456168
Interaction	HRAS interactions	MLH3 CDC42BPA RASGRF1 SLC26A2 TTC21A DOCK9 ROR2 DCBLD1 PPP1R13B UPF1 CEMIP2 ADD2 ADD3	1.72e-05	725	89	13	int:HRAS
Interaction	RAC3 interactions	AHCYL1 ARAP3 CDC42BPA DOCK9 ROR2 DCBLD1 FRYL C2CD2 CEMIP2 ADD2 ADD3 ITPR1	1.74e-05	619	89	12	int:RAC3
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	AHCYL1 PPP1R16B PPP1R13B ELL TP53BP2 ITPR1	5.12e-05	181	66	6	694
GeneFamily	MutL homologs	PMS2 MLH3	7.84e-05	4	66	2	1027
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1D CACNA1F	1.14e-04	26	66	3	253
GeneFamily	WD repeat domain containing	DMXL2 RRP9 TLE4 WSB2 DMXL1 WDR48	3.84e-04	262	66	6	362
GeneFamily	UPF1 like RNA helicases	ZGRF1 UPF1	7.07e-04	11	66	2	1169
GeneFamily	Cadherin related	FAT2 FAT3	1.72e-03	17	66	2	24
GeneFamily	Ankyrin repeat domain containing	ARAP3 ANKDD1A PPP1R16B PPP1R13B TP53BP2	1.90e-03	242	66	5	403
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4B ARAP3 RASGRF1 DOCK9	6.80e-03	206	66	4	682
GeneFamily	Tudor domain containing	TDRKH TDRD9	8.05e-03	37	66	2	780
GeneFamily	Olfactory receptors, family 4	OR4C16 OR4A47 OR4A4P	1.17e-02	129	66	3	151
GeneFamily	Nuclear hormone receptors	RORB NR1I3	1.38e-02	49	66	2	71
Coexpression	CUI_TCF21_TARGETS_2_DN	LIFR WWC2 FRY TLE4 PPP1R16B PPP1R13B WSB2 SHE FRYL TMEM64 CEMIP2 DMXL1 SIRPG	1.05e-05	888	90	13	MM1018
Coexpression	DAZARD_UV_RESPONSE_CLUSTER_G6	FAT2 MLH3 TLE4 DOCK9 USP24 FRYL	1.10e-05	145	90	6	M1810
Coexpression	HEVNER_CORTICAL_PLATE_POSTMITOTIC_PROJECTION_NEURONS	DMXL2 RASGRF1 TLE4 FAT3 PPP1R16B CEMIP2	1.19e-05	147	90	6	MM414
Coexpression	GSE37301_MULTIPOTENT_PROGENITOR_VS_COMMON_LYMPHOID_PROGENITOR_UP	PMS2 MDP1 USP24 PPP1R13B ADD3 TANGO6	2.53e-05	168	90	6	M8890
Coexpression	CUI_TCF21_TARGETS_2_DN	LIFR WWC2 FRY TLE4 PPP1R16B PPP1R13B WSB2 SHE FRYL TMEM64 CEMIP2 DMXL1	3.52e-05	854	90	12	M1533
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARAP3 SLC26A2 DOCK9 PPP1R16B DCBLD1 SHE CEMIP2	1.66e-07	193	93	7	ad2df9b77999780860141be6ec366afc0172a331
ToppCell	facs-Heart-LA-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRY ARAP3 DOCK9 PPP1R16B PPP1R13B SHE CEMIP2	1.72e-07	194	93	7	33cc4f1d716cb71d54cdedbe9bbdc0d7b17c4777
ToppCell	facs-Heart-RA-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRY DOCK9 PPP1R16B DCBLD1 PPP1R13B SHE CEMIP2	1.78e-07	195	93	7	f4fdcc0b851392086e9618e76ee6a0b540d5fb3c
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 FAT3 ROR2 TOGARAM2 CEMIP2 SLC5A2	9.03e-07	155	93	6	8fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CACNA1F TTC21A USP24 UPF1 CEMIP2 TANGO6	1.66e-06	172	93	6	a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CACNA1F TTC21A USP24 UPF1 CEMIP2 TANGO6	1.83e-06	175	93	6	f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C LIFR FAT3 ROR2 ELL CEMIP2	3.03e-06	191	93	6	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	RV-09._Endothelium_I\|World / Chamber and Cluster_Paper	LIFR ARAP3 DOCK9 PPP1R16B SHE FRYL	3.22e-06	193	93	6	e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell	RV-09._Endothelium_I\|RV / Chamber and Cluster_Paper	LIFR ARAP3 DOCK9 PPP1R16B SHE FRYL	3.32e-06	194	93	6	7b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ARAP3 DOCK9 DCBLD1 PPP1R13B CEMIP2	3.32e-06	194	93	6	f159ef8541d75a4e98468947f231bb463bec922c
ToppCell	LV-09._Endothelium_I\|World / Chamber and Cluster_Paper	LIFR ARAP3 DOCK9 PPP1R16B SHE FRYL	3.42e-06	195	93	6	19e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCell	facs-Heart-RA-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARAP3 DOCK9 PPP1R16B DCBLD1 SHE CEMIP2	3.42e-06	195	93	6	30c75761079fa1e1a3b84d23c88a222f459d5ce5
ToppCell	LV-09._Endothelium_I\|LV / Chamber and Cluster_Paper	LIFR ARAP3 DOCK9 PPP1R16B SHE FRYL	3.63e-06	197	93	6	f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|356C / Donor, Lineage, Cell class and subclass (all cells)	CACNA1F TTC21A USP24 CEMIP2 TANGO6	2.57e-05	166	93	5	c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1D LIFR FBN2 PPP1R16B HERC2	2.65e-05	167	93	5	774f3264318b002d0df5d06d41d645366038d0bf
ToppCell	facs-MAT-Fat-24m-Lymphocytic-T_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRKH TDRD9 PPP1R16B TMEM64 FAAH	2.73e-05	168	93	5	22fa707689e8d6ca5154103b7374007d644d61c3
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-Alox5+_Lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 TDRKH PMS2 ZC3HC1 TMEM64	3.22e-05	174	93	5	a8bd1fa08bf061a627529a38e5a23a68b6d80697
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 TDRKH PMS2 ZC3HC1 TMEM64	3.22e-05	174	93	5	7f8f6a15a823809effd37c1a5b09ef19b6d67755
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CDC42BPA DOCK9 PPP1R16B SHE FRYL	3.69e-05	179	93	5	2a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARAP3 ZGRF1 DCBLD1 SHE ADD3	3.89e-05	181	93	5	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ARAP3 TTC21A SHE CEMIP2	3.99e-05	182	93	5	f4a5f1c3a04c0566eb96607dab7a0d9a5ebc3fd1
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	CACNA1C FRY FAT3 ENPEP ITPR1	4.10e-05	183	93	5	818fd886e0188091310825f9145fa53328f2c979
ToppCell	COVID-19-Heart-EC_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C ARAP3 DOCK9 SHE ADD2	4.10e-05	183	93	5	ff95382cfed592190d0636d2b750328471f82e0d
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	CACNA1C FRY FAT3 ENPEP ITPR1	4.10e-05	183	93	5	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	DMXL2 AP2A2 MS4A6A ELL CEMIP2	4.32e-05	185	93	5	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	droplet-Heart-nan-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRY ARAP3 DOCK9 PPP1R16B CEMIP2	4.32e-05	185	93	5	a32d5cb596ebac80eb1ac301055e65d420879ec8
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB6 FRY DOCK9 PPP1R16B UPF1	4.54e-05	187	93	5	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB6 FRY DOCK9 PPP1R16B UPF1	4.54e-05	187	93	5	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	CACNA1C FRY FAT3 CLASP2 ITPR1	4.66e-05	188	93	5	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	TCF20 TLE4 ROR2 PPP1R16B ITPR1	4.66e-05	188	93	5	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	PND07-28-samps-Endothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ARAP3 DOCK9 PPP1R16B SHE CEMIP2	4.78e-05	189	93	5	eb2f8c8a90e5e9f6697a2d13274c94f40e1973e4
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ARAP3 DOCK9 PPP1R16B SHE CEMIP2	4.78e-05	189	93	5	d4a25d59d88325d3b20f4287e9b1160c82961a96
ToppCell	COVID-19-lung-Artery_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LIFR ARAP3 DOCK9 SHE FRYL	4.90e-05	190	93	5	07b675befcd1d0a9c90cb17b5d22323468325d51
ToppCell	PND01-03-samps-Endothelial\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ARAP3 DOCK9 PPP1R16B SHE CEMIP2	4.90e-05	190	93	5	1357bd4527399d7013ee33272bda7453f472999a
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ARAP3 DOCK9 PPP1R16B SHE CEMIP2	4.90e-05	190	93	5	5130fb325f80f591b9b36beacb8072c4472304f2
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LIFR CDC42BPA DOCK9 PPP1R16B SHE	4.90e-05	190	93	5	f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCell	droplet-Lung-nan-21m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ARAP3 DOCK9 SHE CEMIP2	5.02e-05	191	93	5	92b2faa72c184b6ae49530fd3b50848510904997
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LIFR ARAP3 CDC42BPA DOCK9 SHE	5.02e-05	191	93	5	50601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	LIFR ARAP3 DOCK9 PPP1R16B SHE	5.02e-05	191	93	5	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	droplet-Lung-nan-21m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ARAP3 DOCK9 SHE CEMIP2	5.02e-05	191	93	5	d0bbbf42d00165a53253c833adef65da6ec36bba
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARAP3 DOCK9 PPP1R16B PPP1R13B SHE	5.15e-05	192	93	5	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	RA-09._Endothelium_I\|RA / Chamber and Cluster_Paper	LIFR ARAP3 DOCK9 PPP1R16B SHE	5.15e-05	192	93	5	8a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ARAP3 DOCK9 PPP1R13B CEMIP2	5.15e-05	192	93	5	4bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FRY DOCK9 PPP1R13B SHE MYLK2	5.28e-05	193	93	5	3f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCell	droplet-Fat-Mat-18m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRY ARAP3 DOCK9 DCBLD1 SHE	5.28e-05	193	93	5	54024a373e42e1c0bcc327dc084564b83b63a9d4
ToppCell	droplet-Fat-Mat-18m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRY ARAP3 DOCK9 DCBLD1 SHE	5.28e-05	193	93	5	81d908594d2983ba7e7c1ec25afdde4315d9690e
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LIFR ARAP3 DOCK9 PPP1R16B SHE	5.28e-05	193	93	5	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	facs-Heart-RA-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK9 PPP1R16B DCBLD1 PPP1R13B SHE	5.28e-05	193	93	5	e7805e866339f676e3f770980c2e0a649eff472e
ToppCell	facs-Heart-RA-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK9 PPP1R16B DCBLD1 PPP1R13B SHE	5.28e-05	193	93	5	1ad941098f1a44a46c2f6ebff32a98ada32c80ab
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	CACNA1C CACNA1D FAT3 ROR2 ENPEP	5.28e-05	193	93	5	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARAP3 SLC26A2 DOCK9 PPP1R16B SHE	5.28e-05	193	93	5	ff6e6b825d6c88148216c601580be3c28851ab5c
ToppCell	droplet-Lung-nan-18m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARAP3 DOCK9 PPP1R16B SHE CEMIP2	5.28e-05	193	93	5	2f387fb763448b7c351da19a55765375e782c790
ToppCell	droplet-Lung-nan-18m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARAP3 DOCK9 PPP1R16B SHE CEMIP2	5.28e-05	193	93	5	8748af38bfbbbb431ff9d9d5fa75934b5869293a
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C CACNA1D LIFR FAT3 ROR2	5.41e-05	194	93	5	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CACNA1D LIFR FAT3 ROR2 DCBLD1	5.41e-05	194	93	5	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LIFR ARAP3 DOCK9 SHE CEMIP2	5.41e-05	194	93	5	68004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1C ARAP3 DOCK9 PPP1R16B SHE	5.54e-05	195	93	5	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ARAP3 PPP1R16B SHE CEMIP2	5.54e-05	195	93	5	52b2bbf12e5f86c493f6634697aeb23a68cc916d
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CACNA1D LIFR FAT3 ROR2 DCBLD1	5.54e-05	195	93	5	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	CACNA1C CACNA1D FAT3 ROR2 ENPEP	5.54e-05	195	93	5	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ARAP3 PPP1R16B SHE CEMIP2	5.54e-05	195	93	5	e5f14f6015ea5e6fa065f906ad22157e3de15c68
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ARAP3 PPP1R16B SHE CEMIP2	5.54e-05	195	93	5	5b84fd5be31386eb1d6048bbf28626032361842e
ToppCell	facs-Lung-ENDOMUCIN-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ARAP3 PPP1R16B SHE CEMIP2	5.68e-05	196	93	5	f6df26ab9eebae893768a4f70a064ce9f60da93c
ToppCell	facs-Lung-ENDOMUCIN\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR ARAP3 PPP1R16B SHE CEMIP2	5.68e-05	196	93	5	69f03546c42c942ab8ac8746167c8d44d574b4c6
ToppCell	COVID-19-lung-Capillary_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LIFR ARAP3 DOCK9 SHE CEMIP2	5.68e-05	196	93	5	ac28e9be288af6f00a841aea4ce4b99aed6b4505
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR DCBLD1 SHE ENPEP CEMIP2	5.82e-05	197	93	5	deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIFR DCBLD1 SHE ENPEP CEMIP2	5.82e-05	197	93	5	a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCell	COVID-19-lung-Capillary_1\|lung / Disease (COVID-19 only), tissue and cell type	LIFR ARAP3 DOCK9 SHE CEMIP2	5.82e-05	197	93	5	7e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CACNA1C CACNA1D LIFR FAT3 ADD3	5.82e-05	197	93	5	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARAP3 SLC26A2 DOCK9 PPP1R16B SHE	5.82e-05	197	93	5	6a3c647af41fea923311562575a0d656fbc13cbe
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CACNA1C CACNA1D LIFR FAT3 ADD3	5.82e-05	197	93	5	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FRY ARAP3 SLC26A2 DOCK9 HERC2	5.96e-05	198	93	5	0a4626b51ba8b52acbaf616f0ced850079cd7149
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CACNA1F CDS1 RRP9 FAAH TP53BP2	5.96e-05	198	93	5	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CACNA1C CACNA1D LIFR FAT3 ROR2	5.96e-05	198	93	5	17dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C CACNA1D LIFR FAT3 ROR2	5.96e-05	198	93	5	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	CACNA1C CACNA1D FAT3 ROR2 ENPEP	6.10e-05	199	93	5	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	PCW_10-12-Mesenchymal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CACNA1C CACNA1D LIFR FAT3 ROR2	6.10e-05	199	93	5	a09292de4c4447b8eee55d401808e43b817321cc
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CACNA1C FRY CDC42BPA CEMIP2 ADD3	6.25e-05	200	93	5	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	medial-Endothelial-Capillary\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LIFR SLC26A2 DOCK9 SHE CEMIP2	6.25e-05	200	93	5	fd4dcdc67db2a5dbdd54bd2ae975c66df904d4d8
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C CACNA1D FAT3 ROR2 ENPEP	6.25e-05	200	93	5	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C CACNA1D FAT3 ROR2 ENPEP	6.25e-05	200	93	5	8c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CACNA1C FRY CDC42BPA CEMIP2 ADD3	6.25e-05	200	93	5	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	medial-2-Endothelial-Capillary\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LIFR SLC26A2 DOCK9 SHE CEMIP2	6.25e-05	200	93	5	e4f390dfd4dd25600f0f7a17c5523283a5966e92
ToppCell	medial-Endothelial-Capillary-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LIFR SLC26A2 DOCK9 SHE CEMIP2	6.25e-05	200	93	5	4291b5453e98e20ec8150a96ccc865a5964bc645
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CACNA1C FRY CDC42BPA CEMIP2 ADD3	6.25e-05	200	93	5	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C CACNA1D FAT3 ROR2 ENPEP	6.25e-05	200	93	5	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CACNA1C FRY CDC42BPA CEMIP2 ADD3	6.25e-05	200	93	5	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CACNA1C FRY CDC42BPA CEMIP2 ADD3	6.25e-05	200	93	5	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	CACNA1C FRY CDC42BPA CEMIP2 ADD3	6.25e-05	200	93	5	7136936d05ab344a560cf159684c881063b5430d
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	LIFR FAT3 DCBLD1 ZSWIM1	2.23e-04	142	93	4	7b6678a73d04feac12bbc909f2df478215511de0
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	LIFR FAT3 DCBLD1 ZSWIM1	2.23e-04	142	93	4	347f5832a86f4e41752e36e3e737df7ca6f79e90
ToppCell	control-dn_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CACNA1F CELSR3 INTS13 SIRPG	2.55e-04	147	93	4	68258498202c7f580f72c46dd645071835098455
ToppCell	367C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CELSR3 ZNF596 ZC3HC1	2.69e-04	60	93	3	28415d543aaccc74d19e1bb92b7e6fa94f97f8f2
ToppCell	367C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CELSR3 ZNF596 ZC3HC1	2.69e-04	60	93	3	71eba0fbef11cfc2b1c525d5f051530750e4fce9
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ARAP3 CDC42BPA PPP1R16B CEMIP2	3.19e-04	156	93	4	6c8f442ed94ae31e6832b68137e98ae78091ac6c
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARAP3 PPP1R16B C2CD2 NR1I3	3.19e-04	156	93	4	1928c86deb3bcd01db4ae76919a351066aadb39a
ToppCell	COVID-19_Moderate-MAIT\|COVID-19_Moderate / disease group, cell group and cell class	TRBV12-3 ROR2 BRSK1 SIRPG	3.43e-04	159	93	4	6d08d670c34eb6bb8ad5dad3293b3107c006236d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CLEC3A ZNF596 TOGARAM2 ENPEP	3.43e-04	159	93	4	fd7db2f7328cfefdc3ada2af91006d5a91d137e1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CLEC3A ZNF596 TOGARAM2 ENPEP	3.43e-04	159	93	4	aaf449c768d6fbb0a1bb47746ff3bdb7f9eb8914
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CLEC3A ZNF596 TOGARAM2 ENPEP	3.43e-04	159	93	4	8bbdef1e927f3130b578d7d7c5ff38bbe06fab63
Computational	Neighborhood of PTK2	POMT2 AHCYL1 DOCK9 WSB2 CLASP2 FRYL HERC2	9.38e-06	145	56	7	GCM_PTK2
Computational	Neighborhood of PTPRD	POMT2 DOCK9 CLASP2 FRYL HERC2	1.19e-05	58	56	5	GCM_PTPRD
Computational	Neighborhood of MAP4K4	POMT2 AHCYL1 WSB2 CLASP2 FRYL HERC2	2.57e-04	172	56	6	GCM_MAP4K4
Computational	Neighborhood of MAP1B	CDC42BPA WSB2 CLASP2 HERC2	3.53e-04	65	56	4	GCM_MAP1B
Drug	Cinnarizine	CACNA1C CACNA1D CACNA1F	4.93e-06	9	90	3	DB00568
Drug	Nimodipine	CACNA1C CACNA1D CACNA1F	4.93e-06	9	90	3	DB00393
Drug	AC1L2AC7	CACNA1C CACNA1D CACNA1F SHE ITPR1	7.94e-06	69	90	5	CID000068733
Drug	CNS 1145	CACNA1C CACNA1D CACNA1F ITPR1	8.56e-06	33	90	4	CID000190902
Drug	IHC-64	CACNA1C CACNA1D CACNA1F ITPR1	8.56e-06	33	90	4	CID000162753
Drug	Mibefradil	CACNA1C CACNA1D CACNA1F	9.63e-06	11	90	3	DB01388
Drug	Moricizine hydrochloride [31883-05-3]; Up 200; 8.6uM; MCF7; HT_HG-U133A	CACNA1D LIG4 CDC42BPA AP2A2 SLC26A2 DOCK9 PACRG	1.29e-05	196	90	7	6000_UP
Drug	N-cyclopentyl-N-cyclobutylformamide	CACNA1C CACNA1D CACNA1F ELL ITPR1	1.54e-05	79	90	5	CID005287890
Drug	Verapamil	CACNA1C CACNA1D CACNA1F	3.22e-05	16	90	3	DB00661
Drug	nitrendipine	CACNA1C CACNA1D CACNA1F SHE ITPR1	4.39e-05	98	90	5	CID000004507
Drug	Cinildipine	CACNA1C CACNA1D CACNA1F ITPR1	7.17e-05	56	90	4	CID000002752
Drug	NSC-686960	CACNA1C CACNA1D	9.22e-05	4	90	2	CID000192816
Drug	4-amino-4-phosphonobutyric acid	PACRG ENPEP	9.22e-05	4	90	2	CID000098450
Drug	butyl phosphorotrithioate	NR1I3 FAAH	9.22e-05	4	90	2	ctd:C006863
Drug	nilvadipine	CACNA1C CACNA1D CACNA1F ITPR1	9.40e-05	60	90	4	CID000004494
Drug	IAA-94	CACNA1C CACNA1D CACNA1F ITPR1	1.00e-04	61	90	4	CID000003667
Drug	thioridazine hydrochloride; Down 200; 10uM; HL60; HT_HG-U133A	WWC2 CAD RRP9 UPF1 MS4A6A C2CD2	1.06e-04	189	90	6	1171_DN
Drug	lercanidipine	CACNA1C CACNA1D CACNA1F ITPR1	1.14e-04	63	90	4	CID000065866
Drug	Biperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A	POMT2 TDRKH NEK1 MLH3 CDC42BPA AP2A2	1.22e-04	194	90	6	3321_DN
Drug	Viomycin sulfate [37883-00-4]; Down 200; 5.2uM; MCF7; HT_HG-U133A	LIG4 TDRKH CDC42BPA AP2A2 TMEM127 CEMIP2	1.22e-04	194	90	6	7036_DN
Drug	Thioguanosine [85-31-4]; Down 200; 12.6uM; HL60; HT_HG-U133A	POP5 NDUFAF7 CLASP2 MS4A6A DMXL1 WDR48	1.22e-04	194	90	6	1264_DN
Drug	Pyrvinium pamoate [3546-41-6]; Down 200; 3.4uM; PC3; HT_HG-U133A	POMT2 EPHB6 NDUFAF7 RRP9 USP24 CLASP2	1.25e-04	195	90	6	6339_DN
Drug	Mebhydroline 1,5-naphtalenedisulfonate [6153-33-9]; Down 200; 4.8uM; MCF7; HT_HG-U133A	LIG4 TDRKH AP2A2 SLC26A2 NDUFAF7 ENPEP	1.25e-04	195	90	6	3269_DN
Drug	Phenacetin [62-44-2]; Up 200; 22.4uM; PC3; HT_HG-U133A	CELSR3 RASGRF1 TLE4 MS4A6A ENPEP ADD2	1.29e-04	196	90	6	3992_UP
Drug	(1)-Nipecotic acid [498-95-3]; Up 200; 31uM; MCF7; HT_HG-U133A	CACNA1D LIG4 RASGRF1 TLE4 DOCK9 RORB	1.29e-04	196	90	6	5999_UP
Drug	genistein; Down 200; 10uM; MCF7; HT_HG-U133A	NEK1 CDC42BPA AP2A2 NDUFAF7 ADD3 WDR48	1.29e-04	196	90	6	6994_DN
Drug	Cetirizine dihydrochloride [83881-52-1]; Down 200; 8.6uM; MCF7; HT_HG-U133A	LIG4 NEK1 NDUFAF7 RRP9 ENPEP FAAH	1.29e-04	196	90	6	2829_DN
Drug	Tolfenamic acid [13710-19-5]; Down 200; 15.2uM; PC3; HT_HG-U133A	POMT2 LIG4 MLH3 AP2A2 CEMIP2 ITPR1	1.36e-04	198	90	6	2120_DN
Drug	Chlorzoxazone [95-25-0]; Down 200; 23.6uM; PC3; HT_HG-U133A	POMT2 MLH3 AP2A2 TLE4 USP24 FRYL	1.36e-04	198	90	6	2100_DN
Drug	Milrinone [78415-72-2]; Up 200; 19uM; MCF7; HT_HG-U133A	POMT2 NEK1 DOCK9 MS4A6A ENPEP SLC5A2	1.36e-04	198	90	6	7210_UP
Drug	Sulfadoxine [2447-57-6]; Down 200; 12.8uM; MCF7; HT_HG-U133A	AP2A2 TLE4 USP24 UPF1 FAAH CEMIP2	1.40e-04	199	90	6	7205_DN
Drug	Atropine sulfate monohydrate [5908-99-6]; Down 200; 5.8uM; MCF7; HT_HG-U133A	MLH3 RRP9 TLE4 CLASP2 TMEM127 CEMIP2	1.40e-04	199	90	6	7219_DN
Drug	bepridil	CACNA1C CACNA1D CACNA1F MYLK2 ITPR1	1.45e-04	126	90	5	CID000002351
Drug	gallopamil	CACNA1C CACNA1D CACNA1F ITPR1	1.45e-04	67	90	4	CID000001234
Drug	Nilvadipine	CACNA1C CACNA1D	1.53e-04	5	90	2	DB06712
Drug	Nisoldipine	CACNA1C CACNA1D	1.53e-04	5	90	2	DB00401
Drug	B 874-67	CACNA1C CACNA1D	1.53e-04	5	90	2	CID000195466
Drug	methyl beta-aminocrotonate	CACNA1C CACNA1D	1.53e-04	5	90	2	CID000084253
Drug	nemadipine-A	CACNA1C CACNA1D	1.53e-04	5	90	2	CID002856102
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1C CACNA1D CACNA1F	1.02e-07	4	88	3	DOID:0060173 (implicated_via_orthology)
Disease	spastic quadriplegic cerebral palsy 3 (implicated_via_orthology)	ADD2 ADD3	2.63e-05	3	88	2	DOID:0081361 (implicated_via_orthology)
Disease	attention deficit hyperactivity disorder, schizophrenia	CACNA1C PPP1R16B PPP1R13B SIRPG	4.09e-05	64	88	4	EFO_0003888, MONDO_0005090
Disease	Disproportionate short stature	LIFR NEK1 SLC26A2 ROR2	8.46e-05	77	88	4	C0878659
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1C CACNA1D CACNA1F	1.70e-04	36	88	3	DOID:11723 (implicated_via_orthology)
Disease	Abnormality of refraction	CACNA1D FRY FBN2 TDRD9 RASGRF1 FAT3 FRMPD2 RORB ADD3	1.82e-04	673	88	9	HP_0000539
Disease	erythronate measurement	CACNA1D PACRG	1.83e-04	7	88	2	EFO_0021025
Disease	Colorectal Carcinoma	EPHB6 LIFR PMS2 CAD MLH3 FBN2 ARAP3 INTS13 FRMPD2	2.49e-04	702	88	9	C0009402
Disease	refractive error, age at onset, Myopia	CACNA1D TDRD9 RASGRF1 FRMPD2 RORB	2.87e-04	193	88	5	EFO_0004847, HP_0000545, MONDO_0004892
Disease	Lynch Syndrome	PMS2 MLH3	3.12e-04	9	88	2	C4552100
Disease	cerebral palsy (implicated_via_orthology)	ADD2 ADD3	3.90e-04	10	88	2	DOID:1969 (implicated_via_orthology)
Disease	Anemia, Sickle Cell	CACNA1C CAD	3.90e-04	10	88	2	C0002895
Disease	birth weight, pelvic organ prolapse	FBN2 ARAP3 DOCK9	4.28e-04	49	88	3	EFO_0004344, EFO_0004710
Disease	Calcium channel blocker use measurement	CACNA1C CACNA1D FBN2 ZC3HC1 ENPEP	4.51e-04	213	88	5	EFO_0009930
Disease	clonal hematopoiesis mutation measurement	HERC2 ELL ITPR1	6.01e-04	55	88	3	EFO_0020949
Disease	retinal vasculature measurement	CACNA1C FRY PMS2 CDC42BPA ROR2 HERC2 ITPR1	9.10e-04	517	88	7	EFO_0010554
Disease	Manic Disorder	CACNA1C CACNA1D ADD3	1.27e-03	71	88	3	C0024713
Disease	osteochondrodysplasia (is_implicated_in)	LIFR SLC26A2	1.45e-03	19	88	2	DOID:2256 (is_implicated_in)
Disease	Manic	CACNA1C CACNA1D ADD3	1.66e-03	78	88	3	C0338831
Disease	Diuretic use measurement	CACNA1D FBN2 ENPEP OR4A4P	1.67e-03	169	88	4	EFO_0009928
Disease	bipolar disorder	CACNA1C TCF20 TDRD9 TLE4 DCBLD1 PPP1R13B ADD3	1.71e-03	577	88	7	MONDO_0004985
Disease	Depression, Bipolar	CACNA1C CACNA1D ADD3	1.72e-03	79	88	3	C0005587
Disease	temperament and character inventory	SEPSECS FBN2	2.33e-03	24	88	2	EFO_0004825
Disease	Lynch syndrome (is_implicated_in)	PMS2 MLH3	2.33e-03	24	88	2	DOID:3883 (is_implicated_in)
Disease	unipolar depression, schizophrenia	CACNA1C PPP1R16B	2.52e-03	25	88	2	EFO_0003761, MONDO_0005090
Disease	paracentral lobule volume measurement	DOCK9 PACRG	2.52e-03	25	88	2	EFO_0010317
Disease	isthmus cingulate cortex volume measurement	SEPSECS TCF20	2.73e-03	26	88	2	EFO_0010310
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	PMS2 MLH3	2.73e-03	26	88	2	C0009405
Disease	Hereditary non-polyposis colorectal cancer syndrome	PMS2 MLH3	2.94e-03	27	88	2	C1112155
Disease	hypertension, COVID-19	CACNA1D ENPEP	2.94e-03	27	88	2	EFO_0000537, MONDO_0100096
Disease	azoospermia (implicated_via_orthology)	TDRKH CDC42BPA	2.94e-03	27	88	2	DOID:14227 (implicated_via_orthology)
Disease	refractive error	CACNA1D TDRD9 RASGRF1 FRMPD2 RORB	2.96e-03	326	88	5	MONDO_0004892

Protein segments in the cluster

Peptide	Gene	Start	Entry
VHLDCLGSIQDKITV	ELL	106	P55199
IIVDACISFVTQHGL	ARAP3	921	Q8WWN8
LGIQVKCFHEIITIG	CDS1	116	Q92903
VKCVIHIHTLATAAV	ADD3	226	Q9UEY8
AILSHLVKCIAGEVA	DMXL2	1366	Q8TDJ6
ITVVIKCSLEIHGLF	ADCY10	116	Q96PN6
GGVICTQVHKQTVVQ	DHX32	111	Q7L7V1
LSHLVKCIAGEVVAL	DMXL1	1346	Q9Y485
SVHLCKQLVESGAAI	PPP1R13B	966	Q96KQ4
AVCAGHTEIVKFLVQ	TP53BP2	966	Q13625
AGIIHTKTTQIGCLL	AP2A2	891	O94973
CVTLKVLQHLVVSAE	PACRG	166	Q96M98
SILHGLVAAVETLCK	INTS13	121	Q9NVM9
ISLLKGAAVEICHIV	NR1I3	191	Q14994
LKHVVQCVFVAIRTI	CACNA1F	986	O60840
KVCCLTINSHVVILL	OR2T1	16	O43869
IVAVTAEGKQHALCV	MCTS2	131	A0A3B3IRV3
LITGEKKVQCISHEI	NEK1	846	Q96PY6
RNIVDVSKLGVTCIH	MDP1	126	Q86V88
HLVELLAVCTEGKNV	ITPR1	1386	Q14643
KVLLGHRVIQVACGS	HERC2	3146	O95714
LATCGHLVLKVQAID	FAT2	2391	Q9NYQ8
VKLCSTGFITHVVQN	MLH3	601	Q9UHC1
VCTDTHAIGLLVVAN	OR4A47	186	Q6IF82
NILCVNTTGHLVKII	MYLK2	411	Q9H1R3
KIILHFLISICGVNS	FRYL	1401	O94915
TKHVAILCAVVVGVG	ENPEP	16	Q07075
AATCGHINLVKILVQ	PPP1R16B	141	Q96T49
LHVGGTIRTCQKFLI	POP5	101	Q969H6
VVLGAKQLILVGDHC	UPF1	661	Q92900
KVVVCHVVGQAIQFL	C2CD2	126	Q9Y426
KHVVQCVFVAIRTIG	CACNA1C	1036	Q13936
VARIEKVLQGSITHC	DOCK9	476	Q9BZ29
KVVSCLAEGVSHVII	LIG4	851	P49917
LQVDGVILCGLTHKQ	FRMPD2	1001	Q68DX3
LVQHCTLKVRSIDSG	FAT3	2356	Q8TDW7
CITVHGTNGLLIKDT	CEMIP2	581	Q9UHN6
GVHCITGQKVAIKIV	BRSK1	51	Q8TDC3
LHAEIKVIGTIQILC	MS4A6A	41	Q9H2W1
CDSVVVHVLKLQGAV	FAAH	166	O00519
TIVQAHCKLGLTATL	ERCC3	456	P19447
KLVHVLSLCGQEVGL	FRY	2396	Q5TBA9
TGLTILNQTIDICKH	FBN2	486	P35556
GLHSVTAQCVLRVVI	CELSR3	1251	Q9NYQ7
TSLLCKAAIHAGIIA	DCBLD1	196	Q8N8Z6
LKHVVQCVFVAIRTI	CACNA1D	1001	Q01668
CVSQEKVLSALIGHT	LIFR	271	P42702
IKKALSTCVSHIIVV	OR4C16	231	Q8NGL9
ACTDTHVIGLLVVAN	OR4A4P	186	Q8NGN8
RQTTAAVGVLKAVHC	RSBN1L	581	Q6PCB5
SLVTVGKHLTARVLC	POMT2	271	Q9UKY4
QKTEHSCVINIGVAK	TBC1D21	191	Q8IYX1
VSGCTLLVKVFSVVH	TDRD9	1041	Q8NDG6
TGKLHDVCLVVTGEV	TOGARAM2	526	Q6ZUX3
LGSVLKNCDISVHLV	NDUFAF7	141	Q7L592
AKIVGCTHITAQTAV	AHCYL1	146	O43865
VLVNSHLVCKVARLG	EPHB6	801	O15197
ITIVQGQTAILHCKV	ROR2	71	Q01974
LLVTVGKTATLHCTV	SIRPG	41	Q9P1W8
VLTCQVKHDGQLAVS	SIRPG	326	Q9P1W8
GVCSIEHQQEITKLK	CDC42BPA	676	Q5VT25
HLTKNGVISLIDCTL	RASGRF1	511	Q13972
HVTIGKVCLESAVEL	BRCC3	221	P46736
ILQILVNSGAKIHCE	ANKDD1A	106	Q495B1
TCKILVLRNHGVVAL	ADD2	281	P35612
IQALQTVCLRGTKVH	CLEC3A	61	O75596
ACITVAHLSTVLGNK	CLASP2	156	O75122
IKLGSDIQVHVTACI	ZC3HC1	236	Q86WB0
GVLIGTFIAHVVCKR	TMEM64	201	Q6YI46
SHLVSIGKQLCKSVV	ZNF596	41	Q8TC21
RVIHLLGEKTTCVSA	WWC2	646	Q6AWC2
VIKGGASIIQCHILN	WDR48	356	Q8TAF3
VQVCKAKAAIHQILT	TDRKH	106	Q9Y2W6
VIVQRCLAGKSLTHI	SLC5A2	296	P31639
CHTQLSGVVTALVLL	SLC26A2	451	P50443
INTLNHGEVVCAVTI	TLE4	481	Q04727
VLRGHQLSITCLVVT	RRP9	141	O43818
IIQCEVVSSLKAVHK	PLEKHG4B	306	Q96PX9
TITAVCNLHGEKLQV	RORB	426	Q92753
LCILVAKHTDAGVIQ	TRBV12-3	11	P01733
LLGSVVHEVTACLIA	TANGO6	991	Q9C0B7
HVVNKCELGAVCTII	TCF20	1636	Q9UGU0
KIIVVSRLCGSHQVI	TTC21A	301	Q8NDW8
TAIKVTQHLGIVGEC	CAD	651	P27708
KSVHQICSGQVVLSL	PMS2	21	P54278
HINVRIVGKHSVCLV	ZNF844	641	Q08AG5
LCILVAKHTDAGVIQ	TRBV12-4	11	A0A0B4J2E0
FEIVKLVTGSLIACH	USP24	666	Q9UPU5
GLVNTISILKSLCEH	ZGRF1	821	Q86YA3
IKLAGVHTVANCFVV	SEPSECS	126	Q9HD40
LIRKLEGHQSSVVSC	WSB2	231	Q9NYS7
LCLGELAVVQKSTHL	ZSWIM1	341	Q9BR11
IALKTSQGCVHIIVA	SHE	431	Q5VZ18
FAHILTVLQCATVIG	TMEM127	131	O75204