Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGTPase regulator activity

DENND5B TBC1D25 MYCBP2 ARHGEF10 RGS3 IQGAP3

9.20e-05507306GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

DENND5B TBC1D25 MYCBP2 ARHGEF10 RGS3 IQGAP3

9.20e-05507306GO:0060589
GeneOntologyMolecularFunctionsmall GTPase binding

DENND5B DMXL2 KCTD13 MYCBP2 IQGAP3

1.07e-04321305GO:0031267
GeneOntologyMolecularFunctionGTPase binding

DENND5B DMXL2 KCTD13 MYCBP2 IQGAP3

1.82e-04360305GO:0051020
GeneOntologyMolecularFunctionmethyltransferase activity

SMYD5 PRDM15 PRDM2

3.93e-03213303GO:0008168
GeneOntologyMolecularFunctiontransferase activity, transferring one-carbon groups

SMYD5 PRDM15 PRDM2

4.52e-03224303GO:0016741
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

SMYD5 PRDM2

4.67e-0368302GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

SMYD5 PRDM2

4.81e-0369302GO:0016278
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

DENND5B MYCBP2 ARHGEF10

4.93e-03231303GO:0005085
GeneOntologyMolecularFunctionhistone methyltransferase activity

SMYD5 PRDM2

5.08e-0371302GO:0042054
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

KCTD13 MYCBP2 KCTD10 RNF146

5.23e-03473304GO:0004842
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

PCGF1 PRDM15

6.89e-0383302GO:1990841
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

KCTD13 MYCBP2 KCTD10 RNF146

6.90e-03512304GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

KCTD13 MYCBP2 KCTD10 RNF146

7.88e-03532304GO:0016755
GeneOntologyMolecularFunctionGTPase activator activity

TBC1D25 RGS3 IQGAP3

8.29e-03279303GO:0005096
GeneOntologyMolecularFunctionprotein methyltransferase activity

SMYD5 PRDM2

1.04e-02103302GO:0008276
GeneOntologyMolecularFunctionN-methyltransferase activity

SMYD5 PRDM2

1.08e-02105302GO:0008170
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

GFI1 PRDM2 PROX1

1.20e-02320303GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

GFI1 PRDM2 PROX1

1.26e-02326303GO:0001217
GeneOntologyBiologicalProcessacinar cell differentiation

ZNF800 PROX1

2.04e-055302GO:0090425
DomainSET

SMYD5 PRDM15 PRDM2

3.92e-0546273SM00317
DomainSET_dom

SMYD5 PRDM15 PRDM2

5.05e-0550273IPR001214
DomainSET

SMYD5 PRDM15 PRDM2

5.05e-0550273PS50280
DomainZnf_C2H2-like

ZNF800 ZNF586 ZNF865 DHX34 PRDM15 GFI1 PRDM2

1.05e-04796277IPR015880
DomainZnF_C2H2

ZNF800 ZNF586 ZNF865 DHX34 PRDM15 GFI1 PRDM2

1.15e-04808277SM00355
Domain-

ZNF800 ZNF586 ZNF865 PRDM15 GFI1 PRDM2

3.48e-046792763.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF800 ZNF586 ZNF865 PRDM15 GFI1 PRDM2

3.91e-04694276IPR013087
DomainZINC_FINGER_C2H2_2

ZNF800 ZNF586 ZNF865 PRDM15 GFI1 PRDM2

7.01e-04775276PS50157
DomainZINC_FINGER_C2H2_1

ZNF800 ZNF586 ZNF865 PRDM15 GFI1 PRDM2

7.11e-04777276PS00028
DomainZnf_C2H2

ZNF800 ZNF586 ZNF865 PRDM15 GFI1 PRDM2

8.56e-04805276IPR007087
Domainzf-C2H2_6

ZNF586 ZNF865 GFI1 PRDM2

1.01e-03314274PF13912
DomainSET

SMYD5 PRDM2

1.59e-0341272PF00856
DomainBTB_2

KCTD13 KCTD10

2.65e-0353272PF02214
DomainT1-type_BTB

KCTD13 KCTD10

2.65e-0353272IPR003131
Domainzf-C2H2

ZNF586 ZNF865 PRDM15 GFI1 PRDM2

2.84e-03693275PF00096
DomainZF_RING_1

PCGF1 MYCBP2 RNF146

8.30e-03291273PS00518
DomainZF_RING_2

PCGF1 MYCBP2 RNF146

8.86e-03298273PS50089
DomainRING

PCGF1 MYCBP2 RNF146

9.44e-03305273SM00184
DomainZnf_RING

PCGF1 MYCBP2 RNF146

1.13e-02326273IPR001841
Pubmed

Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression.

GFI1 PROX1

4.31e-06430222573682
Pubmed

The CRL3BTBD9 E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration.

KCTD13 KCTD10

7.18e-06530232327643
Pubmed

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.

KCTD13 KCTD10

1.08e-05630228963344
Pubmed

Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.

GFI1 PROX1

3.22e-051030218652815
Pubmed

KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.

KCTD13 KCTD10

3.22e-051030238489388
Pubmed

Conditional gene expression in the mouse inner ear using Cre-loxP.

GFI1 PROX1

4.72e-051230222526732
Pubmed

FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region.

TLK2 TBC1D25

1.09e-041830216484223
Pubmed

Gene Expression by Mouse Inner Ear Hair Cells during Development.

GFI1 PROX1

1.22e-041930225904789
Pubmed

Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.

KCTD13 KCTD10

2.49e-042730230404837
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SAC3D1 TBC1D25 MYCBP2 ZNF865 DHX34 IQGAP3

3.13e-04110530635748872
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

TLK2 DMXL2 PCGF1 KCTD13 KCTD10

3.71e-0473030534857952
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TLK2 SAC3D1 MYCBP2 CLUH PRDM2

4.84e-0477430515302935
Pubmed

Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development.

GFI1 PROX1

6.35e-044330225228773
Pubmed

Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.

KCTD13 MYCBP2 KCTD10

7.70e-0420930326389662
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

TLK2 TBC1D25 MYCBP2 CLUH IQGAP3 USH1G

8.05e-04132130627173435
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

PRDM15 PRDM2

1.26e-04171821197
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF800 ZNF586 ZNF865 PRDM15 GFI1

5.42e-0471818528
ToppCellIIH-CD8-antiviral_CD4|IIH / Condition, Cell_class and T cell subcluster

SMYD5 ZNF586 RGS3 GFI1

5.86e-06177304fe73608c40701eca88b260aeb5c0640d7bee72ba
DrugAcyclovir [59277-89-3]; Down 200; 17.8uM; MCF7; HT_HG-U133A

DENND5B DMXL2 KCTD13 DHX34 GFI1

4.62e-061972955643_DN
DiseaseHOMA-B

ARHGEF10 PROX1

1.16e-0355272EFO_0004469
Diseasecognitive function measurement, self reported educational attainment

DMXL2 ZNF800 MYCBP2

4.08e-03355273EFO_0004784, EFO_0008354
DiseaseCiliopathies

USH1G CEP164

4.55e-03110272C4277690
Diseaseobsolete_red blood cell distribution width

ZNF800 CLUH GFI1 KCTD10 RNF146

6.86e-031347275EFO_0005192
DiseaseIGF-1 measurement

DENND5B RNF146 PROX1

9.79e-03488273EFO_0004627

Protein segments in the cluster

PeptideGeneStartEntry
RIRECAKLQRRHHER

USH1G

146

Q495M9
REHRVRRIHVRRHIT

KCTD13

301

Q8WZ19
RVRRIHIKRPDDRAH

KCTD10

296

Q9H3F6
RRVHRKARQPHQEEL

ARHGEF10

1341

O15013
HIQRELRLRGVFLRH

AJM1

901

C9J069
RHQIERRRLQAKREH

DMXL2

2126

Q8TDJ6
EHLGRTKHLKVARRR

RGS3

261

P49796
QRKVDLRRHRETQHG

GFI1

406

Q99684
RNQHRHRHRRKAELV

IQGAP3

1471

Q86VI3
SREHKRRRDRLRLHQ

DRAXIN

136

Q8NBI3
QRRKERLRQHSEHVG

DENND5B

681

Q6ZUT9
RQHEEGAGRRRKVLR

DHX34

726

Q14147
RAQREREHRLHRLEV

SAC3D1

66

A6NKF1
TQINRRRHERRHEAG

PRDM2

401

Q13029
VRAEVRHLRRVLCHR

PCGF1

196

Q9BSM1
VRKHHLGRVLRRARA

TBC1D25

651

Q3MII6
VTQEEAHGVLHRRRR

F7

46

P08709
HQRRHLEGVRRVKRE

PRDM15

871

P57071
HLRAKRARVENIIRG

PROX1

161

Q92786
RRNEHGRRRKIKRDI

RNF146

156

Q9NTX7
EKRQRVIRRHRLEEG

MYCBP2

861

O75592
ERVRNLHIRELKRIH

TLK2

431

Q86UE8
QHKRLEDLRRRHREQ

CEP164

906

Q9UPV0
REARIHVRHVRDLLK

CLUH

126

O75153
SHRQRRLKERERIGE

NKAPL

116

Q5M9Q1
PRRDHKHRNVRTGER

ZNF586

106

Q9NXT0
RQREELLHHVRRLQR

TEX13D

81

A0A0J9YY54
RRETLKRHERIHTGE

ZNF865

561

P0CJ78
NVRRHFDEVHRGLRR

ZNF800

301

Q2TB10
QRERSRHSRHKILRE

SMYD5

356

Q6GMV2