Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoincreased Langerhans cell number

TTC7A CHD9

9.68e-062442MP:0013412
DomainC2H2_Znf_fam

PEG3 PLAG1 PLAGL2

5.21e-0524573IPR027775
Domain-

ANKRD13A ANKRD65 TRPA1 ANKRD60 ANKDD1A DAPK1

1.06e-042485761.25.40.20
DomainANK

ANKRD13A ANKRD65 TRPA1 ANKRD60 ANKDD1A DAPK1

1.13e-04251576SM00248
DomainANK_REPEAT

ANKRD13A ANKRD65 TRPA1 ANKRD60 ANKDD1A DAPK1

1.19e-04253576PS50088
DomainAnkyrin_rpt-contain_dom

ANKRD13A ANKRD65 TRPA1 ANKRD60 ANKDD1A DAPK1

1.21e-04254576IPR020683
DomainANK_REP_REGION

ANKRD13A ANKRD65 TRPA1 ANKRD60 ANKDD1A DAPK1

1.21e-04254576PS50297
DomainAnkyrin_rpt

ANKRD13A ANKRD65 TRPA1 ANKRD60 ANKDD1A DAPK1

1.43e-04262576IPR002110
DomainCadherin_tail

PCDHGA4 PCDHAC2 PCDHA8

1.95e-0437573PF15974
DomainCadherin_CBD

PCDHGA4 PCDHAC2 PCDHA8

1.95e-0437573IPR031904
DomainAnk_2

ANKRD65 TRPA1 ANKRD60 ANKDD1A DAPK1

4.97e-04215575PF12796
DomainAnk

ANKRD13A TRPA1 ANKRD60 ANKDD1A DAPK1

6.48e-04228575PF00023
DomainCadherin_2

PCDHGA4 PCDHAC2 PCDHA8

1.03e-0365573PF08266
DomainCadherin_N

PCDHGA4 PCDHAC2 PCDHA8

1.03e-0365573IPR013164
DomainTPR_1

TTC7A SNX21 TTC4

2.62e-0390573PF00515
DomainTPR_1

TTC7A SNX21 TTC4

2.62e-0390573IPR001440
DomainCadherin_CS

PCDHGA4 PCDHAC2 PCDHA8

4.50e-03109573IPR020894
DomainDeath

ANKDD1A DAPK1

4.55e-0333572PF00531
DomainCADHERIN_1

PCDHGA4 PCDHAC2 PCDHA8

4.98e-03113573PS00232
DomainCadherin

PCDHGA4 PCDHAC2 PCDHA8

4.98e-03113573PF00028
DomainCADHERIN_2

PCDHGA4 PCDHAC2 PCDHA8

5.10e-03114573PS50268
Domain-

PCDHGA4 PCDHAC2 PCDHA8

5.10e-031145732.60.40.60
DomainCA

PCDHGA4 PCDHAC2 PCDHA8

5.23e-03115573SM00112
DomainCadherin-like

PCDHGA4 PCDHAC2 PCDHA8

5.35e-03116573IPR015919
DomainCadherin

PCDHGA4 PCDHAC2 PCDHA8

5.61e-03118573IPR002126
DomainDeath_domain

ANKDD1A DAPK1

6.00e-0338572IPR000488
DomainDEATH_DOMAIN

ANKDD1A DAPK1

6.00e-0338572PS50017
DomainCadherin_C

PCDHGA4 PCDHAC2

7.29e-0342572IPR032455
DomainCadherin_C_2

PCDHGA4 PCDHAC2

7.29e-0342572PF16492
DomainTPR_2

TTC7A SNX21

1.02e-0250572PF07719
DomainTPR_2

TTC7A SNX21

1.02e-0250572IPR013105
DomainFBOX

FBXW5 FBXO27

1.10e-0252572SM00256
Pubmed

TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption.

TRPM6 SLC12A3

2.64e-06257214576148
Pubmed

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

COL4A1 SYNE1 PCNT

6.29e-062257312812986
Pubmed

Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.

ASNS PLAGL2 APOB

6.29e-062257317983586
Pubmed

Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation.

CYP26B1 APOB HNF4A

7.22e-062357315766748
Pubmed

Transcriptional activation capacity of the novel PLAG family of zinc finger proteins.

PLAG1 PLAGL2

7.91e-0635729722527
Pubmed

Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver.

HNF4A TFR2

7.91e-06357226527688
Pubmed

Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11.

PLAG1 PLAGL2

1.58e-05457215585652
Pubmed

A fate-mapping approach reveals the composite origin of the connecting tubule and alerts on "single-cell"-specific KO model of the distal nephron.

SLC12A3 SLC4A1

2.63e-05557227582101
Pubmed

Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine.

APOB HNF4A

2.63e-05557210859308
Pubmed

Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney.

SLC12A3 SLC4A1

3.94e-05657212388412
Pubmed

Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation.

PLAG1 PLAGL2

3.94e-05657215208321
Pubmed

hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9.

COL4A1 ZBTB16 CYP26B1

5.27e-054457334815802
Pubmed

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.

TRPM6 SLC12A3

7.34e-05857233859252
Pubmed

Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.

SLC12A3 APOB

7.34e-05857218496130
Pubmed

GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo.

APOB HNF4A

9.43e-0595729832509
Pubmed

Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.

PCDHGA4 PCDHAC2 PCDHA8

1.15e-045757332633719
Pubmed

Members of the Plag gene family are expressed in complementary and overlapping regions in the developing murine nervous system.

PLAG1 PLAGL2

1.18e-041057216193498
Pubmed

Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.

SLC12A3 HNF4A

1.18e-041057230046000
Pubmed

CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.

PCDHGA4 PCDHAC2 PCDHA8

1.21e-045857330377227
Pubmed

Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation.

HNF4A SLC4A1

1.44e-041157232023452
Pubmed

Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals.

PHF3 SYNE1

1.44e-041157226939788
Pubmed

Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.

ZBTB16 TRPA1

1.72e-041257233220232
Pubmed

GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells.

COL4A1 HNF4A

1.72e-041257234699385
Pubmed

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.

PCDHGA4 PCDHAC2 PCDHA8

1.94e-046857311230163
Pubmed

Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development.

PLAG1 PLAGL2

2.03e-041357230361413
Pubmed

Temporal-Spatial Establishment of Initial Niche for the Primary Spermatogonial Stem Cell Formation Is Determined by an ARID4B Regulatory Network.

ZBTB16 CYP26B1

2.03e-041357228207192
Pubmed

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PCDHGA4 PCDHAC2 PCDHA8

2.30e-047257310380929
Pubmed

Reduced Abd-B Hox function during kidney development results in lineage infidelity.

SLC12A3 HNF4A

2.37e-041457229596840
Pubmed

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.

PCDHGA4 PCDHAC2 PCDHA8

2.49e-047457310817752
Pubmed

β-catenin regulates the formation of multiple nephron segments in the mouse kidney.

SLC12A3 HNF4A

2.73e-041557231685872
Pubmed

Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.

PCDHAC2 PCDHA8

2.73e-041557215640798
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

PCDHGA4 PCDHAC2 PCDHA8

2.80e-047757310835267
Pubmed

Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension.

APOB SLC4A1

3.12e-041657217137217
Pubmed

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PCDHGA4 PCDHAC2 PCDHA8

3.14e-048057310716726
Pubmed

CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways.

ZBTB16 CYP26B1

3.53e-041757224576537
Pubmed

Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.

PCDHAC2 PCDHA8

3.53e-041757229911975
Pubmed

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

BSN HNF4A

3.53e-041757219915572
Pubmed

RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche.

ZBTB16 CYP26B1

3.53e-041757225406395
Pubmed

CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.

PCDHAC2 PCDHA8

3.97e-041857215570159
Pubmed

Genomic organization of the family of CNR cadherin genes in mice and humans.

PCDHAC2 PCDHA8

3.97e-041857210662547
Pubmed

Transcriptional regulation of liver development.

APOB HNF4A

4.43e-041957211002334
Pubmed

Npat-dependent programmed Sertoli cell proliferation is indispensable for testis cord development and germ cell mitotic arrest.

ZBTB16 CYP26B1

4.43e-041957231084574
Pubmed

Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells.

SLC12A3 SLC4A1

4.43e-041957234667084
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

TTC7A PHF3 SYNE1 PCNT

5.15e-0422557412168954
Pubmed

Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.

SLC12A3 SLC4A1

5.43e-042157219855135
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

ELOA2 ZBTB16 RBM14 PLAGL2 TRIM29 HNF4A PBXIP1

5.59e-0487757720211142
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

KIF26A PHF3 SYNE1 BSN

5.87e-0423357437704626
Pubmed

Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.

TTC7A APOB

6.53e-042357220932654
Pubmed

Hepatocyte nuclear factor 1β controls nephron tubular development.

SLC12A3 HNF4A

6.53e-042357223362349
Pubmed

Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.

LATS2 HNF4A

6.53e-042357227531557
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPM6 TRPA1

7.12e-042457233884443
Pubmed

Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse.

SLC12A3 SLC4A1

7.12e-042457217079272
Pubmed

Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.

PCDHAC2 PCDHA8

7.12e-042457224698270
Pubmed

Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.

APOB HNF4A

7.73e-042557221784065
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPM6 TRPA1

7.73e-042557216382100
Pubmed

The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells.

ZBTB16 CYP26B1

7.73e-042557225344072
Pubmed

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.

INSM1 HNF4A

8.36e-042657228193997
Pubmed

Retinoic acid deficiency impairs the vestibular function.

CYP26B1 OTOP1

8.36e-042657223536097
Pubmed

ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.

SYNE1 CHD9 BSN

8.60e-0411357334474245
Pubmed

Identification of 15 loci influencing height in a Korean population.

ANKRD60 PLAG1

9.02e-042757219893584
Pubmed

An introduction to TRP channels.

TRPM6 TRPA1

9.02e-042757216460286
Pubmed

Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo.

APOB HNF4A

9.71e-042857216109169
Pubmed

Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.

PCDHGA4 PCDHA8

9.71e-042857215347688
Pubmed

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.

LATS2 HNF4A

1.04e-032957227358050
Pubmed

Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.

COL4A1 TRIM29

1.11e-033057220083228
Pubmed

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.

CYP26B1 LATS2

1.19e-033157236362374
Pubmed

FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.

PEG3 RBM14 HERC1

1.23e-0312857328027390
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPM6 TRPA1

1.35e-033357219834762
Pubmed

Functional significance of isoform diversification in the protocadherin gamma gene cluster.

PCDHGA4 BSN

1.43e-033457222884324
Pubmed

Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency.

SLC12A3 ASNS

1.43e-033457235341793
Pubmed

The DNA sequence and comparative analysis of human chromosome 20.

ANKRD60 INSM1 PLAGL2 SNX21 HNF4A

1.58e-0351757511780052
Pubmed

A critical role for NF2 and the Hippo pathway in branching morphogenesis.

LATS2 HNF4A

1.60e-033657227480037
Pubmed

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.

SLC12A3 HNF4A

1.60e-033657233737325
Cytoband16q24

ZNF469 APRT

2.04e-041757216q24
Cytoband5q31

PCDHGA4 PCDHAC2 PCDHA8

4.06e-041155735q31
GeneFamilyAnkyrin repeat domain containing

ANKRD13A ANKRD65 TRPA1 ANKRD60 ANKDD1A DAPK1

1.64e-05242416403
GeneFamilyClustered protocadherins

PCDHGA4 PCDHAC2 PCDHA8

4.10e-046441320
GeneFamilyTransient receptor potential cation channels

TRPM6 TRPA1

1.83e-0328412249
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

TTC7A SNX21 TTC4

2.24e-03115413769
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PLA2G4C HMCN2 BSN SLC4A1

7.65e-0698574cb0941481aef9068d7dbce0d1b6cf125f482a98d
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PLA2G4C HMCN2 BSN SLC4A1

7.65e-0698574a74fb790c135bd0d0033df3aca7b789d8b25e361
DiseaseNephritis, Interstitial

SLC12A3 APRT SLC4A1

1.08e-0524533C0027707
DiseaseRenal tubular acidosis

SLC12A3 SLC4A1

1.89e-054532C0001126
Diseaseplatelet crit

COL4A1 ZBTB16 KIF26A ANKDD1A FBXW5 PLAG1 APOB KIAA1614 TFR2

4.52e-05952539EFO_0007985
DiseaseAnemia, Hemolytic, Acquired

COL4A1 SLC4A1

2.44e-0413532C0002879
DiseaseAnemia, Hemolytic

COL4A1 SLC4A1

2.44e-0413532C0002878
DiseaseAnemia, Microangiopathic

COL4A1 SLC4A1

2.44e-0413532C0002889
DiseaseMicroangiopathic hemolytic anemia

COL4A1 SLC4A1

2.44e-0413532C0221021
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

HERC1 BSN

4.75e-0418532HP_0002373
DiseaseNephritis, Tubulointerstitial

SLC12A3 SLC4A1

6.50e-0421532C0041349
Diseasefacial width measurement

LATS2 DAPK1 TRIM29

9.01e-04105533EFO_0007855
Diseasehepatocellular carcinoma (biomarker_via_orthology)

ASNS APRT HNF4A

9.78e-04108533DOID:684 (biomarker_via_orthology)
Diseaselevel of Sterol ester (27:1/18:2) in blood serum

APOB HNF4A

1.00e-0326532OBA_2045194
Diseaselevel of Sterol ester (27:1/16:0) in blood serum

APOB HNF4A

1.00e-0326532OBA_2045191
Diseaseeye measurement

ZNF469 HERC1

1.08e-0327532EFO_0004731
Diseasetotal cholesterol measurement, low density lipoprotein cholesterol measurement

APOB HNF4A TFR2

1.14e-03114533EFO_0004574, EFO_0004611
Diseasecholesteryl ester measurement, low density lipoprotein cholesterol measurement

APOB HNF4A TFR2

1.52e-03126533EFO_0004611, EFO_0010351

Protein segments in the cluster

PeptideGeneStartEntry
LLAARKVADHIGSEH

ASNS

296

P08243
EHVAGLLARLRKDTH

DAPK1

656

P53355
EELLRALLLKHSHAG

SLC4A1

151

P02730
AARRLRKLGLHDFDH

BCDIN3D

206

Q7Z5W3
LLLQHGASIHDRDAK

ANKRD60

271

Q9BZ19
ASAHKEDAHLRPRAG

CREG2

76

Q8IUH2
AAIGLLARHLKATHG

APRT

41

P07741
LLLHEEHSRAAAKGG

COL4A1

16

P02462
AGALRAIEALHGHEL

RBM14

46

Q96PK6
LGHLESARVLLRHKA

ANKRD13A

51

Q8IZ07
HKSRLLHAEGSRLAG

PCDHGA4

751

Q9Y5G9
KRDVLDLRGRHHEAS

NUP210

1216

Q8TEM1
LRKHQHVGDFARDLA

ELOA2

56

Q8IYF1
LRKSLDREDAPAHHL

PCDHA8

196

Q9Y5H6
RGLFLHAKRLAHLDL

LRRC55

106

Q6ZSA7
DHRLGRNGADDLKAH

LATS2

956

Q9NRM7
HSIRADGSLHLDRAL

HMCN2

931

Q8NDA2
KLRDELRAHGILHSG

CYP26B1

321

Q9NR63
RAALRKQHAAELHLG

HERC1

1891

Q15751
SHRKAALAGLLRLGD

KIAA1614

821

Q5VZ46
AAKPHARDLGRHEAR

BSN

3666

Q9UPA5
RAHAGEHLLLGATKR

HNF4A

221

P41235
AHAKEGLRHFLDRVL

FBXW5

296

Q969U6
ARASKVEAAHRLAGH

KIF26A

1421

Q9ULI4
LREEAVAKALHHLGR

LRGUK

106

Q96M69
SALHRAAARGHLLAV

ANKRD65

271

E5RJM6
TKHAADLGALETRHL

PCNT

951

O95613
KSAALAEHRKIHARG

PEG3

516

Q9GZU2
LRKGLDREQAALHHL

PCDHAC2

211

Q9Y5I4
AHRRLFRLKDTHAGA

OTOP1

116

Q7RTM1
SSRKHLHLVDAGLAI

PLA2G4C

376

Q9UP65
TAHSKALHGRELRDL

FCSK

406

Q8N0W3
KAHLDIAGSLEGHLR

APOB

3656

P04114
HDRDLLIGAAKHGVS

CHD9

1966

Q3L8U1
AHILASEALRADKGH

SDR42E1

231

Q8WUS8
LARDHGATGRALLHL

FBXO27

71

Q8NI29
DKLAADCAHELRRHG

DHRS1

171

Q96LJ7
ASKGAQERHLRLLHA

INSM1

451

Q01101
LRKAAHLEVHREGDG

PHTF2

206

Q8N3S3
ELHLKPHLEGAAFRD

TRIM29

196

Q14134
AHLGDKRRDLAHLAA

TRIM39

231

Q9HCM9
HLAKLGSLGRAEDLH

SYNE1

1826

Q8NF91
DLKHRGVLSALSRFH

SEC31B

56

Q9NQW1
LLEHLKAHSRRVAGG

PLAGL2

171

Q9UPG8
ALDHVDKLGRTAFHR

ANKDD1A

151

Q495B1
FKRHLALHAATSGDL

PLAG1

136

Q6DJT9
AREGHAKAVALLLSH

TRPA1

556

O75762
RLRMHLLAHSAGAKA

ZBTB16

446

Q05516
RAADLLAFTHKHLAD

TRPM6

321

Q9BX84
HAGLAELGHRLAQKL

PBXIP1

426

Q96AQ6
ASRLLHRLRHALAGD

SNX21

11

Q969T3
HKDKERARLSHGDRG

PHF3

1966

Q92576
LADLHSFLKQEGRHL

SLC12A3

86

P55017
RVPADAHAGLLSHAK

ZNF469

781

Q96JG9
VRKDDAHALHLLALL

TTC7A

561

Q9ULT0
RGALCHLELKHFAEA

TTC4

156

O95801
RGDHTLGALLDHLRL

TFR2

736

Q9UP52