Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF419 MYCL ZNF8 HINFP ZNF250 ZNF717 ZNF17 ZNF776 ZNF146 HDAC5 ZNF154 HDAC4 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZFP14 ZNF683 ZFHX3 ZNF528 RREB1 ZNF467 ZNF417 ZNF471 TET3 ZNF548 ZFP82 ZNF710 ZNF461	3.36e-18	1244	81	32	GO:0000978
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF419 MYCL ZNF8 HINFP ZNF250 ZNF717 ZNF17 ZNF776 ZNF146 HDAC5 ZNF154 HDAC4 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZFP14 ZNF683 ZFHX3 ZNF749 ZNF528 RREB1 ZNF467 ZNF417 ZNF471 TET3 ZNF548 ZFP82 ZNF518A ZNF710 ZNF461	4.19e-18	1459	81	34	GO:0000977
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF419 MYCL ZNF8 HINFP ZNF250 ZNF717 ZNF17 ZNF776 ZNF146 HDAC5 ZNF154 HDAC4 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZFP14 ZNF683 ZFHX3 ZNF528 RREB1 ZNF467 ZNF417 ZNF471 TET3 ZNF548 ZFP82 ZNF710 ZNF461	6.29e-18	1271	81	32	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF419 MYCL ZNF8 HINFP ZNF250 ZNF717 ZNF17 ZNF776 ZNF146 HDAC5 ZNF154 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZFP14 ZFHX3 ZNF749 ZNF528 RREB1 ZNF467 ZNF417 ZNF471 ZNF548 ZFP82 ZNF518A ZNF461	9.38e-15	1412	81	30	GO:0000981
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in ventral spinal cord interneuron specification	GLI2 GLI3	4.56e-05	3	81	2	GO:0021775
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	GLI2 GLI3	4.56e-05	3	81	2	GO:0021776
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in ventral spinal cord patterning	GLI2 GLI3	4.56e-05	3	81	2	GO:0021910
GeneOntologyBiologicalProcess	osteoblast development	HDAC5 HDAC4 GLI2	5.40e-05	19	81	3	GO:0002076
GeneOntologyCellularComponent	GLI-SUFU complex	GLI2 GLI3	8.85e-05	4	81	2	GO:1990788
GeneOntologyCellularComponent	transcription repressor complex	HDAC5 HDAC4 GLI3 CTBP2	3.65e-04	87	81	4	GO:0017053
MousePheno	abnormal brain ventricular system morphology	FREM2 PTPN9 GLI2 GLI3 ZNF423 FES POLRMT SLC4A10 HTT	9.04e-06	393	50	9	MP:0002200
MousePheno	abnormal thalamus morphology	GLI3 ZNF423 HTT SOD2	4.01e-05	54	50	4	MP:0000832
MousePheno	reduced cerebellar foliation	GLI2 GLI3 ZNF423	4.70e-05	20	50	3	MP:0009719
MousePheno	enlarged cerebral aqueduct	GLI3 HTT	7.49e-05	4	50	2	MP:0031442
MousePheno	premature lambdoid suture closure	HDAC4 GLI3	7.49e-05	4	50	2	MP:0030356
MousePheno	acoria	FREM2 GLI3	7.49e-05	4	50	2	MP:0012101
MousePheno	lethality throughout fetal growth and development, incomplete penetrance	TRPM6 PTPN9 TRIO FES HTT SOD2	9.30e-05	208	50	6	MP:0011109
MousePheno	abnormal right lung accessory lobe morphology	GLI2 GLI3	1.25e-04	5	50	2	MP:0009571
MousePheno	lethality throughout fetal growth and development	TRPM6 PTPN9 TRIO NADK2 FES CTBP2 HTT SOD2	1.40e-04	435	50	8	MP:0006208
MousePheno	exencephaly	TRPM6 PTPN9 HDAC4 GLI2 GLI3 HTT	1.61e-04	230	50	6	MP:0000914
MousePheno	enlarged lateral ventricles	PTPN9 ZNF423 FES HTT	2.26e-04	84	50	4	MP:0008535
MousePheno	abnormal ear shape	FREM2 HTT	2.60e-04	7	50	2	MP:0000022
MousePheno	abnormal lateral ventricle morphology	PTPN9 GLI3 ZNF423 FES HTT	2.89e-04	164	50	5	MP:0000823
MousePheno	abnormal cerebellum development	GLI2 GLI3 ZNF423 HTT	3.78e-04	96	50	4	MP:0000854
Domain	Znf_C2H2/integrase_DNA-bd	ZNF419 ZNF8 HINFP ZNF250 ZNF17 ZNF776 ZNF146 ZNF154 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF683 ZFHX3 ZNF749 ZNF528 ZNF230 RREB1 ZNF467 CHAMP1 ZNF417 ZNF471 ZNF548 ZFP82 ZNF518A ZNF710 ZNF461	2.19e-25	694	79	32	IPR013087
Domain	-	ZNF419 ZNF8 HINFP ZNF250 ZNF17 ZNF776 ZNF146 ZNF154 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF683 ZFHX3 ZNF749 ZNF528 ZNF230 RREB1 ZNF467 CHAMP1 ZNF417 ZNF471 ZNF548 ZFP82 ZNF710 ZNF461	2.06e-24	679	79	31	3.30.160.60
Domain	zf-C2H2	ZNF419 ZNF8 HINFP ZNF250 ZNF17 ZNF776 ZNF146 ZNF154 ZNF175 GLI2 ZNF423 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF683 ZFHX3 ZNF749 ZNF528 ZNF230 RREB1 ZNF467 CHAMP1 ZNF417 ZNF471 ZNF548 ZFP82 ZNF518A ZNF710 ZNF461	3.80e-24	693	79	31	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF419 ZNF8 HINFP ZNF250 ZNF17 ZNF776 ZNF146 ZNF154 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF683 ZFHX3 ZNF749 ZNF528 ZNF230 RREB1 ZNF467 CHAMP1 ZNF417 ZNF471 ZNF548 ZFP82 ZNF518A ZNF710 ZNF461	6.60e-24	775	79	32	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF419 ZNF8 HINFP ZNF250 ZNF17 ZNF776 ZNF146 ZNF154 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF683 ZFHX3 ZNF749 ZNF528 ZNF230 RREB1 ZNF467 CHAMP1 ZNF417 ZNF471 ZNF548 ZFP82 ZNF518A ZNF710 ZNF461	7.15e-24	777	79	32	PS00028
Domain	Znf_C2H2-like	ZNF419 ZNF8 HINFP ZNF250 ZNF17 ZNF776 ZNF146 ZNF154 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF683 ZFHX3 ZNF749 ZNF528 ZNF230 RREB1 ZNF467 CHAMP1 ZNF417 ZNF471 ZNF548 ZFP82 ZNF518A ZNF710 ZNF461	1.50e-23	796	79	32	IPR015880
Domain	Znf_C2H2	ZNF419 ZNF8 HINFP ZNF250 ZNF17 ZNF776 ZNF146 ZNF154 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF683 ZFHX3 ZNF749 ZNF528 ZNF230 RREB1 ZNF467 CHAMP1 ZNF417 ZNF471 ZNF548 ZFP82 ZNF518A ZNF710 ZNF461	2.11e-23	805	79	32	IPR007087
Domain	ZnF_C2H2	ZNF419 ZNF8 HINFP ZNF250 ZNF17 ZNF776 ZNF146 ZNF154 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF683 ZFHX3 ZNF749 ZNF528 ZNF230 RREB1 ZNF467 CHAMP1 ZNF417 ZNF471 ZNF548 ZFP82 ZNF518A ZNF710 ZNF461	2.37e-23	808	79	32	SM00355
Domain	KRAB	ZNF419 ZNF8 ZNF250 ZNF17 ZNF776 ZNF154 ZNF175 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF749 ZNF528 ZNF230 ZNF417 ZNF471 ZNF548 ZFP82 ZNF461	2.50e-17	358	79	20	PS50805
Domain	KRAB	ZNF419 ZNF8 ZNF250 ZNF17 ZNF776 ZNF154 ZNF175 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF749 ZNF528 ZNF230 ZNF417 ZNF471 ZNF548 ZFP82 ZNF461	2.50e-17	358	79	20	PF01352
Domain	KRAB	ZNF419 ZNF8 ZNF250 ZNF17 ZNF776 ZNF154 ZNF175 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF749 ZNF528 ZNF230 ZNF417 ZNF471 ZNF548 ZFP82 ZNF461	4.51e-17	369	79	20	SM00349
Domain	KRAB	ZNF419 ZNF8 ZNF250 ZNF17 ZNF776 ZNF154 ZNF175 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF749 ZNF528 ZNF230 ZNF417 ZNF471 ZNF548 ZFP82 ZNF461	4.75e-17	370	79	20	IPR001909
Domain	zf-C2H2_6	ZNF419 ZNF8 ZNF250 ZNF17 ZNF154 ZNF423 ZNF587 ZNF780B ZNF256 ZFP14 ZNF749 RREB1 ZNF467 ZNF417 ZNF548 ZFP82 ZNF710 ZNF461	7.72e-16	314	79	18	PF13912
Domain	Hist_deacetylase_Gln_rich_N	HDAC5 HDAC4	5.29e-05	3	79	2	IPR024643
Domain	HDAC4_Gln	HDAC5 HDAC4	5.29e-05	3	79	2	PF12203
Domain	Histone_deAcase_II_euk	HDAC5 HDAC4	1.05e-04	4	79	2	IPR017320
Domain	DUF3398	DOCK11 DOCK9	2.62e-04	6	79	2	PF11878
Domain	DOCK_C/D_N	DOCK11 DOCK9	2.62e-04	6	79	2	IPR021816
Domain	Hist_deacetyl	HDAC5 HDAC4	9.48e-04	11	79	2	PF00850
Domain	His_deacetylse_dom	HDAC5 HDAC4	9.48e-04	11	79	2	IPR023801
Domain	DOCK_C	DOCK11 DOCK9	9.48e-04	11	79	2	IPR010703
Domain	DHR-1_domain	DOCK11 DOCK9	9.48e-04	11	79	2	IPR027007
Domain	DHR_2	DOCK11 DOCK9	9.48e-04	11	79	2	PS51651
Domain	DHR_1	DOCK11 DOCK9	9.48e-04	11	79	2	PS51650
Domain	DOCK-C2	DOCK11 DOCK9	9.48e-04	11	79	2	PF14429
Domain	DHR-2	DOCK11 DOCK9	9.48e-04	11	79	2	IPR027357
Domain	DHR-2	DOCK11 DOCK9	9.48e-04	11	79	2	PF06920
Domain	-	HDAC5 HDAC4	9.48e-04	11	79	2	3.40.800.20
Domain	His_deacetylse	HDAC5 HDAC4	9.48e-04	11	79	2	IPR000286
Domain	DOCK	DOCK11 DOCK9	9.48e-04	11	79	2	IPR026791
Domain	CRAL_TRIO	PTPN9 TRIO	3.52e-03	21	79	2	PF00650
Domain	Pentatricopeptide_repeat	POLRMT HTT	4.22e-03	23	79	2	IPR002885
Domain	-	PTPN9 TRIO	4.22e-03	23	79	2	3.40.525.10
Domain	Spectrin	TRIO MACF1	4.22e-03	23	79	2	PF00435
Domain	SEC14	PTPN9 TRIO	4.98e-03	25	79	2	SM00516
Domain	CRAL_TRIO	PTPN9 TRIO	5.79e-03	27	79	2	PS50191
Domain	CRAL-TRIO_dom	PTPN9 TRIO	6.22e-03	28	79	2	IPR001251
Domain	Spectrin_repeat	TRIO MACF1	6.66e-03	29	79	2	IPR002017
Domain	Spectrin/alpha-actinin	TRIO MACF1	8.07e-03	32	79	2	IPR018159
Domain	SPEC	TRIO MACF1	8.07e-03	32	79	2	SM00150
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF419 ZNF250 ZNF717 ZNF17 ZNF776 PLK2 HDAC5 ZNF154 HDAC4 ZNF175 GLI2 GLI3 CAMK2G ZNF587 ZNF256 ZIM2 ZFP14 ZFHX3 ZNF749 ZNF528 ZNF230 ZNF417 ZNF471 ZNF548 HTT SOD2 ZNF710 ZNF461	4.37e-14	1387	57	28	M734
Pathway	REACTOME_RUNX2_REGULATES_CHONDROCYTE_MATURATION	HDAC4 GLI2	1.59e-04	5	57	2	M27804
Pathway	REACTOME_RUNX2_REGULATES_BONE_DEVELOPMENT	HDAC4 GLI2 GLI3	2.60e-04	31	57	3	M27805
Pathway	REACTOME_GLI_PROTEINS_BIND_PROMOTERS_OF_HH_RESPONSIVE_GENES_TO_PROMOTE_TRANSCRIPTION	GLI2 GLI3	3.33e-04	7	57	2	M27501
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF419 ZNF8 ZNF250 ZNF17 ZNF776 ZNF587 ZNF749 ZNF417 ZFP82	4.33e-10	181	81	9	37372979
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF250 PLK2 ZNF146 WASHC4 RBM27 GLI2 GLI3 CAMK2G AHCTF1 SLC39A10 ZNF467 CHAMP1 ZNF417 PLOD1 ZFP82 SOD2 ZNF518A	2.07e-09	1203	81	17	29180619
Pubmed	Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.	HDAC5 HDAC4 GLI2 GLI3	2.68e-08	14	81	4	22549777
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TTC7A ZNF8 WAPL ZNF146 GLI3 AHCTF1 POLRMT RNF213 MACF1 ZFHX3 RREB1 CHAMP1 ZFP82 ZNF518A ZNF461	4.03e-08	1116	81	15	31753913
Pubmed	The DNA sequence and biology of human chromosome 19.	ZNF17 ZNF146 ZNF175 ZNF780B POLRMT ZNF749 ZNF230 ZNF471	3.44e-07	284	81	8	15057824
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZNF8 HDAC5 CAMK2G POLRMT ZFHX3 CTBP2 RREB1 CHAMP1 VCPIP1	5.84e-07	418	81	9	34709266
Pubmed	The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia.	CYP11A1 GLI2 GLI3	1.98e-06	11	81	3	21586556
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HDAC5 ZNF423 DOCK9 LRRTM2 MACF1 SLC39A10 TET3 VCPIP1	5.01e-06	407	81	8	12693553
Pubmed	Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells.	HDAC5 HDAC4	5.36e-06	2	81	2	29472387
Pubmed	Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.	HDAC5 HDAC4	5.36e-06	2	81	2	27626651
Pubmed	Normal exon copy number of the GLI2 and GLI3 genes in patients with esophageal atresia.	GLI2 GLI3	5.36e-06	2	81	2	23442119
Pubmed	A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome.	GLI2 GLI3	5.36e-06	2	81	2	17283082
Pubmed	Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling.	HDAC5 HDAC4	5.36e-06	2	81	2	17975112
Pubmed	New mouse models of congenital anorectal malformations.	GLI2 GLI3	5.36e-06	2	81	2	10693670
Pubmed	Nuclear calcium signaling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity.	HDAC5 HDAC4	5.36e-06	2	81	2	23364788
Pubmed	Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription.	HDAC5 HDAC4	5.36e-06	2	81	2	31375688
Pubmed	Class II histone deacetylases downregulate GLUT4 transcription in response to increased cAMP signaling in cultured adipocytes and fasting mice.	HDAC5 HDAC4	5.36e-06	2	81	2	22403301
Pubmed	Adult Gli2+/-;Gli3Δ699/+ Male and Female Mice Display a Spectrum of Genital Malformation.	GLI2 GLI3	5.36e-06	2	81	2	27814383
Pubmed	Differential effects of GLI2 and GLI3 in regulating cervical cancer malignancy in vitro and in vivo.	GLI2 GLI3	5.36e-06	2	81	2	29967343
Pubmed	Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.	GLI2 GLI3	5.36e-06	2	81	2	20154143
Pubmed	Control of cardiac growth by histone acetylation/deacetylation.	HDAC5 HDAC4	5.36e-06	2	81	2	16397154
Pubmed	HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.	HDAC4 HTT	5.36e-06	2	81	2	24302884
Pubmed	A study on etiology of incontinence in double knockout mouse model.	GLI2 GLI3	5.36e-06	2	81	2	36272934
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HDAC4 TRIO GLI2 ZNF587 RNF213 MACF1 ZFHX3 CTBP2 ZNF528 PLOD1 TET3 DNAH14 HTT ZNF461	8.11e-06	1489	81	14	28611215
Pubmed	A census of human transcription factors: function, expression and evolution.	MYCL HINFP ZNF146 ZNF175 GLI2 GLI3 AHCTF1 ZFHX3 ZNFX1 ZNF230 RREB1	8.29e-06	908	81	11	19274049
Pubmed	Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway.	GLI2 GLI3	1.60e-05	3	81	2	11172440
Pubmed	Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.	GLI2 GLI3	1.60e-05	3	81	2	26010061
Pubmed	A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.	GLI2 GLI3	1.60e-05	3	81	2	8387379
Pubmed	Roles of the DOCK-D family proteins in a mouse model of neuroinflammation.	DOCK11 DOCK9	1.60e-05	3	81	2	32241915
Pubmed	Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase.	GLI2 GLI3	1.60e-05	3	81	2	38968120
Pubmed	Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin.	HDAC4 HTT	1.60e-05	3	81	2	26540094
Pubmed	Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.	GLI2 GLI3	1.60e-05	3	81	2	16571352
Pubmed	NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers.	HDAC5 HDAC4	1.60e-05	3	81	2	22648949
Pubmed	Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development.	GLI2 GLI3	1.60e-05	3	81	2	22178118
Pubmed	Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.	HDAC5 HDAC4	1.60e-05	3	81	2	11509672
Pubmed	G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity.	HDAC5 HDAC4	1.60e-05	3	81	2	16221676
Pubmed	Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation.	HDAC5 HDAC4	1.60e-05	3	81	2	34502418
Pubmed	Histone deacetylase 5 is a phosphorylation substrate of protein kinase D in osteoclasts.	HDAC5 HDAC4	1.60e-05	3	81	2	35318161
Pubmed	Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase.	GLI2 GLI3	1.60e-05	3	81	2	19955409
Pubmed	Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylases.	HDAC5 HDAC4	1.60e-05	3	81	2	23297420
Pubmed	A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction.	HDAC5 HDAC4	1.60e-05	3	81	2	32612176
Pubmed	Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.	HDAC4 CAMK2G	1.60e-05	3	81	2	25489064
Pubmed	Sonic hedgehog through Gli2 and Gli3 is required for the proper development of placental labyrinth.	GLI2 GLI3	1.60e-05	3	81	2	25695606
Pubmed	Gli family members are differentially expressed during the mitotic phase of spermatogenesis.	GLI2 GLI3	1.60e-05	3	81	2	9178901
Pubmed	Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.	GLI2 GLI3	1.60e-05	3	81	2	8378770
Pubmed	GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation.	CYP11A1 GLI2 GLI3	2.38e-05	24	81	3	32497091
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	INTS6L ZNF17 TRIO MACF1 ZNF230	2.84e-05	151	81	5	17043677
Pubmed	Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region.	GLI2 GLI3	3.20e-05	4	81	2	9027508
Pubmed	Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5.	HDAC5 HDAC4	3.20e-05	4	81	2	17949687
Pubmed	Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina.	GLI2 GLI3	3.20e-05	4	81	2	22281533
Pubmed	Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.	GLI2 GLI3	3.20e-05	4	81	2	9006072
Pubmed	Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.	GLI2 GLI3	3.20e-05	4	81	2	27793025
Pubmed	Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.	HDAC5 HDAC4	3.20e-05	4	81	2	28688716
Pubmed	Non-canonical activation of hedgehog in prostate cancer cells mediated by the interaction of transcriptionally active androgen receptor proteins with Gli3.	GLI2 GLI3	3.20e-05	4	81	2	29429990
Pubmed	Expression profile of Gli family members and Shh in normal and mutant mouse limb development.	GLI2 GLI3	3.20e-05	4	81	2	9438426
Pubmed	Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development.	GLI2 GLI3	3.20e-05	4	81	2	8150204
Pubmed	Up-regulation of HO-1 promotes resistance of B-cell acute lymphocytic leukemia cells to HDAC4/5 inhibitor LMK-235 via the Smad7 pathway.	HDAC5 HDAC4	3.20e-05	4	81	2	29886060
Pubmed	SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes.	HDAC5 HDAC4	3.20e-05	4	81	2	17468767
Pubmed	Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.	WAPL RNF213	3.20e-05	4	81	2	18187866
Pubmed	The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.	GLI2 GLI3	3.20e-05	4	81	2	24952464
Pubmed	PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy.	HDAC5 HDAC4	3.20e-05	4	81	2	30843886
Pubmed	SIKs control osteocyte responses to parathyroid hormone.	HDAC5 HDAC4	3.20e-05	4	81	2	27759007
Pubmed	Class IIa histone deacetylases: conducting development and differentiation.	HDAC5 HDAC4	3.20e-05	4	81	2	19412888
Pubmed	mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity.	HDAC5 HDAC4	3.20e-05	4	81	2	10748098
Pubmed	Anorectal malformations caused by defects in sonic hedgehog signaling.	GLI2 GLI3	3.20e-05	4	81	2	11485934
Pubmed	Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes.	HDAC5 HDAC4	3.20e-05	4	81	2	17011572
Pubmed	HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1.	HDAC5 HDAC4	3.20e-05	4	81	2	31784580
Pubmed	A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes.	GLI2 GLI3	3.20e-05	4	81	2	20956384
Pubmed	Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.	GLI2 GLI3	3.20e-05	4	81	2	10531011
Pubmed	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	HDAC5 HDAC4 HTT	3.82e-05	28	81	3	25752541
Pubmed	MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation.	CYP11A1 GLI2 GLI3	3.82e-05	28	81	3	29879378
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	MYCL ZNF146 GLI2 GLI3 MACF1 ZFP14 ZFHX3 ZNF467 CHAMP1	4.08e-05	709	81	9	22988430
Pubmed	Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.	ZNF8 CHAMP1 ZFP82 ZNF518A	4.36e-05	83	81	4	20562864
Pubmed	Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases.	HDAC5 HDAC4	5.33e-05	5	81	2	10983972
Pubmed	SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.	GLI2 GLI3	5.33e-05	5	81	2	20711444
Pubmed	Functional compensation in Hedgehog signaling during mouse prostate development.	GLI2 GLI3	5.33e-05	5	81	2	16707121
Pubmed	A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.	GLI2 GLI3	5.33e-05	5	81	2	9118802
Pubmed	Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1.	HDAC5 HDAC4	5.33e-05	5	81	2	15194749
Pubmed	Evidence for the involvement of the Gli gene family in embryonic mouse lung development.	GLI2 GLI3	5.33e-05	5	81	2	9268579
Pubmed	A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP.	HDAC5 HDAC4	5.33e-05	5	81	2	17379597
Pubmed	Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.	HDAC5 CAMK2G	5.33e-05	5	81	2	18218981
Pubmed	Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.	HDAC5 HDAC4	5.33e-05	5	81	2	16166628
Pubmed	Immediate effects of a single exercise bout on protein O-GlcNAcylation and chromatin regulation of cardiac hypertrophy.	HDAC5 HDAC4	5.33e-05	5	81	2	23624624
Pubmed	Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration.	GLI2 GLI3	5.33e-05	5	81	2	24218555
Pubmed	Gli regulation by the opposing activities of fused and suppressor of fused.	GLI2 GLI3	5.33e-05	5	81	2	10806483
Pubmed	p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9.	GLI2 GLI3	5.33e-05	5	81	2	26282181
Pubmed	Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.	GLI2 GLI3	5.33e-05	5	81	2	9216996
Pubmed	HDAC4 integrates PTH and sympathetic signaling in osteoblasts.	HDAC5 HDAC4	5.33e-05	5	81	2	24934156
Pubmed	CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy.	HDAC5 HDAC4	5.33e-05	5	81	2	16767219
Pubmed	Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain.	GLI2 GLI3	5.33e-05	5	81	2	15614767
Pubmed	Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.	GLI2 GLI3	5.33e-05	5	81	2	19996099
Pubmed	Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.	DOCK11 DOCK9	5.33e-05	5	81	2	15710388
Pubmed	Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1.	HDAC5 HDAC4	5.33e-05	5	81	2	19071119
Pubmed	PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms.	GLI2 GLI3	5.33e-05	5	81	2	17328886
Pubmed	Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor.	HDAC5 HDAC4	5.33e-05	5	81	2	19893013
Pubmed	Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.	GLI2 GLI3	5.33e-05	5	81	2	16611981
Pubmed	Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.	GLI2 GLI3	5.33e-05	5	81	2	15315762
Pubmed	Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5.	HDAC5 HDAC4	5.33e-05	5	81	2	11114197
Pubmed	Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.	GLI2 GLI3	5.33e-05	5	81	2	10564661
Pubmed	Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart.	HDAC5 HDAC4	5.33e-05	5	81	2	21282606
Interaction	ZNF287 interactions	ZNF8 HINFP TMEM62 GLI2 GLI3 ZNF423 ZNF710	3.87e-09	60	80	7	int:ZNF287
Interaction	ZFP37 interactions	ZNF8 HINFP GLI2 GLI3 ZNF423 ZNF710	3.95e-08	49	80	6	int:ZFP37
Interaction	ZNF667 interactions	ZNF8 HINFP GLI2 GLI3 ZNF423 ZNF710	6.40e-08	53	80	6	int:ZNF667
Interaction	ZNF423 interactions	ZNF8 ZNF17 GLI2 GLI3 ZNF423 ZNF710	4.45e-07	73	80	6	int:ZNF423
Interaction	TRIM28 interactions	ZNF419 ZNF8 ZNF250 ZNF17 ZNF776 WASHC4 HDAC5 HDAC4 ZNF587 ZNF256 FES POLRMT ZIM2 ZNF749 CHAMP1 ZNF417 ZNF471 ZFP82 ZNF518A VCPIP1	8.53e-07	1474	80	20	int:TRIM28
Interaction	ZFP62 interactions	ZNF8 GLI2 GLI3 ZNF423 ZNF467 ZNF710	2.70e-06	99	80	6	int:ZFP62
Interaction	GLI2 interactions	ZNF8 HDAC5 HDAC4 GLI2 GLI3 ZNF423	2.70e-06	99	80	6	int:GLI2
Interaction	TRIM39 interactions	ZNF419 ZNF8 HINFP ZNF17 ZNF776 ZIM2	4.49e-06	108	80	6	int:TRIM39
Interaction	ZNF710 interactions	ZNF8 HINFP ZNF423 ZNF710	5.83e-06	30	80	4	int:ZNF710
Interaction	CCDC125 interactions	ZNF250 HDAC4 ZNF587 ZNF230 ZNF417	6.92e-06	67	80	5	int:CCDC125
Interaction	MYNN interactions	ZNF8 GLI2 ZNF423 ZNF710	7.61e-06	32	80	4	int:MYNN
Interaction	RNF4 interactions	ZNF250 PLK2 ZNF146 WASHC4 RBM27 GLI2 GLI3 CAMK2G AHCTF1 SLC39A10 ZNF467 CHAMP1 ZNF417 PLOD1 ZFP82 HTT SOD2 ZNF518A	8.11e-06	1412	80	18	int:RNF4
Interaction	ZNF8 interactions	ZNF8 HINFP GLI2 ZNF423 ZNF710	8.59e-06	70	80	5	int:ZNF8
Interaction	ZBTB17 interactions	ZNF8 HINFP GLI2 ZNF423 ZNF710	1.37e-05	77	80	5	int:ZBTB17
Interaction	MTUS2 interactions	ZNF250 ZNF17 HDAC5 HDAC4 ZNF587 MACF1 ZFHX3 ZNF230 ZNF417	1.58e-05	370	80	9	int:MTUS2
Interaction	PRDM5 interactions	ZNF8 HINFP GLI2 ZNF423 ZNF710	1.65e-05	80	80	5	int:PRDM5
Interaction	GOLGA6L9 interactions	ZNF250 ZNF17 HDAC4 ZNF587 ZFHX3 ZNF230 ZNF417	2.41e-05	216	80	7	int:GOLGA6L9
Interaction	ZNF768 interactions	ZNF250 GLI3 ZNF423 ZNF467 ZNF417 ZNF710	3.05e-05	151	80	6	int:ZNF768
Interaction	ZNF547 interactions	ZNF250 ZNF587 ZNF417	3.93e-05	17	80	3	int:ZNF547
Interaction	CBX3 interactions	ZNF8 ZNF250 ZNF776 WAPL RBM27 AHCTF1 MACF1 RREB1 CHAMP1 ZFP82 ZNF518A	4.74e-05	646	80	11	int:CBX3
Interaction	ZNF473 interactions	ZNF250 GLI3 ZNF423 ZNF710	7.23e-05	56	80	4	int:ZNF473
Interaction	CEP70 interactions	ZNF250 ZNF17 HDAC4 ZNF587 ZFHX3 ZNF417 SOD2	8.20e-05	262	80	7	int:CEP70
Interaction	CBX5 interactions	ZNF8 ZNF17 ZNF776 HDAC5 HDAC4 CHAMP1 ZFP82 ZNF518A	8.40e-05	356	80	8	int:CBX5
Interaction	BEGAIN interactions	ZNF250 HDAC4 ZNF587 ZNF417	8.88e-05	59	80	4	int:BEGAIN
Interaction	IKZF2 interactions	HDAC5 HDAC4 CTBP2	1.47e-04	26	80	3	int:IKZF2
Interaction	ZSCAN10 interactions	GLI3 ZNF423 ZNF710	1.47e-04	26	80	3	int:ZSCAN10
Interaction	KRTAP10-7 interactions	ZNF419 ZNF250 ZNF175 ZNF587 ZNF256 ZIM2 ZNF417	1.64e-04	293	80	7	int:KRTAP10-7
Interaction	TTC23 interactions	TRIO ZIM2 ZFHX3 RREB1 HTT VCPIP1	1.79e-04	208	80	6	int:TTC23
Interaction	MYOCD interactions	HDAC5 HDAC4 ZNF467	2.04e-04	29	80	3	int:MYOCD
Interaction	ZFP3 interactions	GLI3 ZNF423 ZNF710	2.26e-04	30	80	3	int:ZFP3
Interaction	ZNF837 interactions	ZNF250 ZNF17 ZNF587 ZNF417	2.76e-04	79	80	4	int:ZNF837
Interaction	ZNF382 interactions	GLI3 ZNF423 ZNF710	3.02e-04	33	80	3	int:ZNF382
Interaction	RBAK interactions	GLI3 ZNF423 ZNF467 ZNF710	3.04e-04	81	80	4	int:RBAK
Interaction	AHRR interactions	HDAC5 HDAC4	3.23e-04	7	80	2	int:AHRR
Interaction	KRT40 interactions	ZNF250 ZNF17 HDAC4 ZNF587 RNF213 ZFHX3 ZNF230 ZNF417	3.24e-04	434	80	8	int:KRT40
Interaction	ZNF652 interactions	GLI3 ZNF423 ZNF710	3.60e-04	35	80	3	int:ZNF652
Interaction	SMAD3 interactions	ZNF8 HDAC5 HDAC4 CYP11A1 GLI3 CAMK2G DOCK9 ZFHX3	3.95e-04	447	80	8	int:SMAD3
Interaction	ZBTB48 interactions	ZNF8 HINFP GLI2 ZNF423 ZNF710	4.16e-04	158	80	5	int:ZBTB48
Interaction	MYF5 interactions	ZNF250 ZNF587 ZNF417	4.25e-04	37	80	3	int:MYF5
Interaction	ZFP28 interactions	HINFP GLI3 ZNF423	4.25e-04	37	80	3	int:ZFP28
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF419 ZNF8 ZNF17 ZNF776 ZNF146 ZNF154 ZNF175 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF749 ZNF528 ZNF230 ZNF417 ZNF471 ZNF548 ZFP82 ZNF461	1.74e-14	1192	81	20	chr19q13
Cytoband	19q13.43	ZNF419 ZNF8 ZNF776 ZNF587 ZNF256 ZNF749 ZNF417 ZNF471 ZNF548	4.80e-14	87	81	9	19q13.43
Cytoband	19q13.4	ZNF17 ZNF154 ZNF175 ZIM2	1.22e-05	79	81	4	19q13.4
Cytoband	19q13.12	ZFP14 ZFP82 ZNF461	2.89e-04	72	81	3	19q13.12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF419 ZNF8 HINFP ZNF250 ZNF717 ZNF17 ZNF776 ZNF146 ZNF154 ZNF175 GLI2 GLI3 ZNF423 ZNF587 ZNF780B ZNF256 ZIM2 ZFP14 ZNF683 ZFHX3 ZNF749 ZNF528 ZNF230 RREB1 ZNF467 CHAMP1 ZNF417 ZNF471 ZNF548 ZFP82 ZNF518A ZNF710 ZNF461	7.92e-30	718	63	33	28
GeneFamily	Histone deacetylases, class IIA	HDAC5 HDAC4	7.14e-05	4	63	2	992
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	INTS6L TRANK1 ZNF175 ZNF423 ZNF528 ZNF461	1.18e-06	189	80	6	bccb3481ffed597c845fe860da658505316105b5
ToppCell	COVID-19-Mast_cells-Transitioning_MDM\|COVID-19 / group, cell type (main and fine annotations)	TRPM6 ZNF250 ZNF17 ZNF230 ZNF467	6.42e-06	145	80	5	5c5fed4620c4c312d1052b8acad910453f7e8fcc
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRANK1 HDAC4 PXT1 CHAMP1 SOD2	7.82e-06	151	80	5	b698ddc74565d47892c09c3f16d78038da2dd5e7
ToppCell	Control-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	INTS6L WAPL WASHC4 MACF1 CCDC191	8.88e-06	155	80	5	0a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	INTS6L WAPL WASHC4 MACF1 CCDC191	1.00e-05	159	80	5	2881b054bbeb479221ee3c38bbd9b0815b123579
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ABCA13 GLI2 ZNF423 ZNF528 ZFP82	1.31e-05	168	80	5	8f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	HINFP ZNF776 ZNF780B ZFHX3 CHAMP1	1.73e-05	178	80	5	9a3581a0158dfa5a1cc942f8c532afb5e38b272a
ToppCell	BAL-Severe-Lymphocyte-B-B_cell\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF717 ZNF17 CCDC78 ZNF230 ZNF461	1.83e-05	180	80	5	c3c72531af5b9f7a7416727fe609dab5180e03b6
ToppCell	BAL-Severe-Lymphocyte-B-B_cell-B_cell-B_activate-7\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF717 ZNF17 CCDC78 ZNF230 ZNF461	1.83e-05	180	80	5	9f4bbaf6435c23e3e552ae22be8ea7884314192d
ToppCell	BAL-Severe-Lymphocyte-B-B_cell-B_cell\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF717 ZNF17 CCDC78 ZNF230 ZNF461	1.83e-05	180	80	5	b465f2f8b0e9a2034a4f1272bb00c77439164dbf
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	WAPL TRANK1 WASHC4 RNF213 MACF1	1.98e-05	183	80	5	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	WAPL TRANK1 ZNF146 CHAMP1 TET3	2.14e-05	186	80	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-AT2-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FREM2 MTRF1 PLK2 LRATD1 ZIM2	2.62e-05	194	80	5	5bfc26668fa8f109f2ebc0d5fd98ab5bd219e62c
ToppCell	VE-NK\|VE / Condition, Cell_class and T cell subcluster	IER5L FES ZFHX3 CTBP2 SLC39A10	2.82e-05	197	80	5	cae6ff8763501e7a5897b50188ac2640d65a47c0
ToppCell	VE-NK-\|VE / Condition, Cell_class and T cell subcluster	IER5L FES ZFHX3 CTBP2 SLC39A10	2.82e-05	197	80	5	ee89b8521fb4faaed9e4d39f7171e45eccf38b00
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PLK2 TRIO DOCK9 RNF213 MACF1	3.03e-05	200	80	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Severe-B_intermediate-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	INTS6L TRANK1 WASHC4 GLI2	4.80e-05	111	80	4	7021009545178fac1f19f3c429bfedb2f38b680d
Disease	Intellectual Disability	HDAC4 TRIO SLC4A10 MACF1 CHAMP1 TET3 HTT	1.01e-04	447	71	7	C3714756
Disease	PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED	HDAC5 HDAC4	1.19e-04	7	71	2	C1969342
Disease	Pulmonary Hypertension, Primary, Fenfluramine-Associated	HDAC5 HDAC4	1.19e-04	7	71	2	C1969343
Disease	Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia	HDAC5 HDAC4	1.19e-04	7	71	2	C3714844
Disease	Pulmonary Hypertension, Primary, 1	HDAC5 HDAC4	1.19e-04	7	71	2	C4552070
Disease	Moyamoya disease	DOCK9 RNF213 PLOD1	1.24e-04	40	71	3	MONDO_0016820
Disease	mean arterial pressure	PLK2 HDAC4 ZNF423 FES SLC4A10 RNF213 ZFHX3	1.98e-04	499	71	7	EFO_0006340
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI2 GLI3	2.03e-04	9	71	2	DOID:0050338 (implicated_via_orthology)
Disease	cortical surface area measurement	TRPM6 GLI3 ZNF423 DOCK9 FES SLC4A10 MACF1 ZFHX3 CTBP2 RREB1 DENND3	3.51e-04	1345	71	11	EFO_0010736
Disease	brain measurement, neuroimaging measurement	FES SLC4A10 MACF1 ZFHX3 CTBP2 RREB1 DENND3	3.57e-04	550	71	7	EFO_0004346, EFO_0004464
Disease	migraine disorder, type 2 diabetes mellitus	GLI3 SLC4A10 RREB1	4.14e-04	60	71	3	MONDO_0005148, MONDO_0005277
Disease	Idiopathic pulmonary arterial hypertension	HDAC5 HDAC4	6.70e-04	16	71	2	C3203102
Disease	serum alanine aminotransferase measurement, response to combination chemotherapy	HDAC4 RNF213 ZFP14	6.79e-04	71	71	3	EFO_0004735, EFO_0007965
Disease	Familial primary pulmonary hypertension	HDAC5 HDAC4	7.58e-04	17	71	2	C0340543
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	TRIO CAMK2G	7.58e-04	17	71	2	DOID:0060307 (is_implicated_in)
Disease	neuroimaging measurement	GLI3 CAMK2G DOCK9 SLC4A10 MACF1 CTBP2 RREB1 DENND3 HTT	1.03e-03	1069	71	9	EFO_0004346
Disease	Seizures	CYP11A1 MACF1 TET3 SOD2	1.91e-03	218	71	4	C0036572
Disease	cortical surface area measurement, neuroimaging measurement	SLC4A10 ZFHX3 CTBP2 RREB1	2.21e-03	227	71	4	EFO_0004346, EFO_0010736
Disease	Movement Disorders	TET3 HTT	2.22e-03	29	71	2	C0026650

Protein segments in the cluster

Peptide	Gene	Start	Entry
KSVHHIFSVQENNHL	TMEM62	401	Q0P6H9
NEHNHHLINDFTIKQ	CTBP2	246	P56545
NITHHQLEKAIHNVL	ABCA13	2806	Q86UQ4
QSLQLHHELHAAHLL	DENND3	321	A2RUS2
QHHHLPQHLHQQQVL	RBM27	701	Q9P2N5
EKINSHHLHNNISHI	INTS6L	841	Q5JSJ4
LHHPHKSVQHVVLQA	PTPN9	116	P43378
HLEHNQLTKINFAHF	LRRTM2	211	O43300
QLVHHINNDHIHGEK	GLI3	496	P10071
SRQHEAQLHEHIKQQ	HDAC4	101	P56524
LLERHHIHTKNVEHI	NADK2	111	Q4G0N4
VTHFTQAQINHHKIA	FREM2	771	Q5SZK8
HHHHLLHQLVLNETQ	LRATD1	71	Q96KN4
QEQLVHHINNEHIHG	GLI2	451	P10070
HHVLKNDVLAHQATV	MACF1	6266	Q9UPN3
FIHNHEQHHKAQVEE	PLOD1	321	Q02809
QVYELTLHHTQHQDH	HTT	356	P42858
LHVHKFFHHCQLIQS	DOCK11	826	Q5JSL3
QLHEKHHLLLTFFHV	DOCK9	721	Q9BZ29
KGAVLHHLVNKHNVH	CHAMP1	721	Q96JM3
HFHNRHVFQQQLIEK	CCDC191	551	Q8NCU4
TTHHLHEQHEAEIFQ	CCDC78	71	A2IDD5
THKVHLHHVQNFQKY	CYP11A1	71	P05108
VAKHHQIHISEEQIA	DNAH14	791	Q0VDD8
ASVQNHEFLLVHHLQ	AHCTF1	946	Q8WYP5
QHDHLTRQHEVQLQK	HDAC5	101	Q9UQL6
KFFEHVTQHLQQHLH	HINFP	31	Q9BQA5
HNHHGENKTVLRKHN	SLC39A10	626	Q9ULF5
LAHHLLVVHHGQRQK	POLRMT	241	O00411
AARHQLHQLHQLHQL	IER5L	106	Q5T953
LESVNHIHQHDIVHR	CAMK2G	121	Q13555
AFSQKSHHIRHQKIH	ZNF146	276	Q15072
RAAQLHHQHHHQLLL	FES	191	P07332
VQTLLQNHKHHDKFT	SLC25A52	141	Q3SY17
CHIQLHSHQFRQIHL	MTRF1	21	O75570
EQIKEYHHLHQAVHA	RNF213	1341	Q63HN8
YHHLHQAVHAAKVIL	RNF213	1346	Q63HN8
ESNNLVIHSVVKHFH	SCLY	101	Q96I15
AFVQHSHLIQHQRVH	ZNF250	431	P15622
AFLTQAHLVGHQKIH	ZNF749	491	O43361
TNTLLHHLVQDVKQH	TRPM6	486	Q9BX84
KHFHISIHQQQHNYA	MYCL	201	P12524
IHHILKQHLHVPEQD	RREB1	806	Q92766
HFADHQETHHKQKLN	ZNF587	106	Q96SQ5
AYLHQHQKQHVGQKH	ZNF256	131	Q9Y2P7
HRVHEALMKQHHHQN	SLC4A10	211	Q6U841
HFADHQETHHKQKLN	ZNF417	106	Q8TAU3
EFSQIHHLKQHSLTH	ZNF710	471	Q8N1W2
NFHEEHEKNSHHIHK	WAPL	171	Q7Z5K2
HINAQIMQLHHSKHH	SOD2	41	P04179
TFVQHIHRHNEIHYK	ZNF518A	221	Q6AHZ1
HQKAQTALQQHLHHK	TET3	521	O43151
HALRENLKQHFQQHL	VCPIP1	236	Q96JH7
AFSLHTQLNHHKNIH	ZNF780B	621	Q9Y6R6
VHTIQEFVHHDENHS	PLEKHA3	131	Q9HB20
KSHQNQHEAHFVVEL	ZNFX1	1126	Q9P2E3
FLQNVHLLQHLKAHE	ZIM2	421	Q9NZV7
RHHEHLTQHHKIQTL	ZNF717	191	Q9BY31
RQHSHLTHHLKIHNV	ZFP82	516	Q8N141
FKQSEHLIQHQRIHT	ZNF471	271	Q9BX82
FNHNAHLTVHKRIHT	ZNF8	266	P17098
QHLQHQALHSISVAK	WASHC4	506	Q2M389
FIHDFQLQKHQIIHT	ZNF230	261	Q9UIE0
HLVHHQKIHSEERLV	ZNF548	491	Q8NEK5
FNQIAHLVRHQKIHT	ZNF528	306	Q3MIS6
FSAQKHHQHALDVVN	TTC7A	576	Q9ULT0
AFRQHSHLTQHQKIH	ZFP14	516	Q9HCL3
HHQKQHLGEKHFRSN	ZNF154	56	Q13106
LAHIHQAHANQKHKC	ZNF423	311	Q2M1K9
IELHRILHHKHVVQF	PLK2	131	Q9NYY3
HQLEHLHQIFVTKNH	TRANK1	1141	O15050
QHIHLEHHQRQQVAY	TRANK1	2776	O15050
FILHRHKQQVQHIHG	VN1R3	206	Q9BXE9
FRHNSTLVQHHKIHT	ZNF419	296	Q96HQ0
EHSIVQKHHQEEIIH	PXT1	66	Q8NFP0
HQHTLFEHQKIHTEE	ZNF17	201	P17021
HKQHLVRHQRVHQTA	ZNF467	311	Q7Z7K2
QKSFTQLAHLQKHHL	ZNF683	356	Q8IZ20
QLAHLQKHHLVHTGE	ZNF683	361	Q8IZ20
HVLDVIHEVLHHQRQ	TRIO	536	O75962
HSHLIQHQRIHTGEK	ZNF461	481	Q8TAF7
SHLNIHQKIHTGERH	ZNF175	516	Q9Y473
LNNKIHLQLHLTHLH	ZFHX3	1261	Q15911
FHQKGSLIQHQQIHS	ZNF776	441	Q68DI1