Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	eukaryotic translation initiation factor 2 complex	EIF2S3B EIF2S3	2.59e-05	6	28	2	GO:0005850
HumanPheno	Abnormal consumption behavior	NPHP3 SYT2 MBD5 LEMD3 MAPT SH2B1	9.87e-07	299	8	6	HP:0040202
HumanPheno	Cerebellar malformation	NPHP3 SYT2 ERF MBD5 LEMD3 SH2B1	1.76e-05	487	8	6	HP:0002438
HumanPheno	Abnormal eating behavior	SYT2 MBD5 MAPT SH2B1	2.46e-05	128	8	4	HP:0100738
HumanPheno	Reduced impulse control	NPHP3 SYT2 MBD5 LEMD3 MAPT EIF2S3 SH2B1	9.08e-05	1032	8	7	HP:5200045
HumanPheno	Polyphagia	MBD5 MAPT SH2B1	1.83e-04	78	8	3	HP:0002591
Domain	TCEAL1	TCEAL6 TCEAL3 TCEAL5	2.25e-07	9	27	3	IPR010370
Domain	BEX	TCEAL6 TCEAL3 TCEAL5	9.70e-07	14	27	3	PF04538
Domain	TF_A-like/BEX	TCEAL6 TCEAL3 TCEAL5	9.70e-07	14	27	3	IPR021156
Domain	NUT	NUTM2F NUTM2G	2.01e-05	5	27	2	IPR024310
Domain	NUT_N	NUTM2F NUTM2G	2.01e-05	5	27	2	IPR024309
Domain	NUT	NUTM2F NUTM2G	2.01e-05	5	27	2	PF12881
Domain	TPR_7	NPHP3 PPID	8.99e-05	10	27	2	PF13176
Domain	TPR_1	NPHP3 PPID	7.45e-03	90	27	2	PF00515
Domain	TPR_1	NPHP3 PPID	7.45e-03	90	27	2	IPR001440
Pathway	REACTOME_RECYCLING_OF_EIF2_GDP	EIF2S3B EIF2S3	5.51e-05	9	18	2	MM15418
Pathway	BIOCARTA_EIF2_PATHWAY	EIF2S3B EIF2S3	6.89e-05	10	18	2	MM1469
Pathway	REACTOME_CELLULAR_RESPONSE_TO_MITOCHONDRIAL_STRESS	EIF2S3B EIF2S3	6.89e-05	10	18	2	MM17234
Pathway	BIOCARTA_EIF_PATHWAY	EIF2S3B EIF2S3	6.89e-05	10	18	2	MM1394
Pathway	REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR	EIF2S3B EIF2S3	1.01e-04	12	18	2	MM14981
Pathway	REACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA	PRKCB LEMD3	1.60e-04	15	18	2	M27360
Pathway	BIOCARTA_IGF1MTOR_PATHWAY	EIF2S3B EIF2S3	2.89e-04	20	18	2	MM1496
Pathway	BIOCARTA_VEGF_PATHWAY	PRKCB EIF2S3	5.30e-04	27	18	2	M12975
Pathway	WP_13Q1212_COPY_NUMBER_VARIATION	SSPN ADIPOQ	8.43e-04	34	18	2	M48103
Pubmed	Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain.	EIF2S3B EIF2S3	6.25e-07	2	28	2	16325480
Pubmed	Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.	TCEAL6 TCEAL3 TCEAL5	9.35e-07	24	28	3	16221301
Pubmed	A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.	TCEAL6 TCEAL3 TCEAL5	1.51e-06	28	28	3	23677977
Pubmed	Human cyclophilin 40 unravels neurotoxic amyloids.	PPID MAPT	3.75e-06	4	28	2	28654636
Pubmed	Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.	EIF2S3B EIF2S3	3.75e-06	4	28	2	31836389
Pubmed	Interaction between NH(2)-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration.	PPID MAPT	6.24e-06	5	28	2	21958963
Pubmed	Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.	EIF2S3B EIF2S3	1.31e-05	7	28	2	15669143
Pubmed	Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution.	EIF2S3B EIF2S3	2.24e-05	9	28	2	9736774
Pubmed	Wnt pathway anomalies in developing amygdalae of Turner syndrome-like mice.	EIF2S3B EIF2S3	2.24e-05	9	28	2	17873295
Pubmed	Phosphorylation of tau is regulated by PKN.	PRKCB MAPT	3.42e-05	11	28	2	11104762
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	PRKCB PLEKHA6 LEMD3 MAPT	3.43e-05	231	28	4	16452087
Pubmed	Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes.	EIF2S3B EIF2S3	4.10e-05	12	28	2	23210685
Pubmed	Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.	EIF2S3B MAPT EIF2S3	4.11e-05	83	28	3	19799774
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	EIF2S3B EIF2S3	6.52e-05	15	28	2	14762062
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	EIF2S3B EIF2S3	9.49e-05	18	28	2	12023983
Pubmed	Genome-wide association study reveals genetic risk underlying Parkinson's disease.	STBD1 MAPT	1.18e-04	20	28	2	19915575
Pubmed	Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions.	TCEAL3 TCEAL5	1.18e-04	20	28	2	33100228
Pubmed	Emergence of young human genes after a burst of retroposition in primates.	EIF2S3B EIF2S3	1.18e-04	20	28	2	16201836
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	PRKCB EIF2S3B SYT2 MAPT EIF2S3	1.25e-04	621	28	5	22794259
Pubmed	Vti1b promotes TRPV1 sensitization during inflammatory pain.	EIF2S3B PLEKHA6 EIF2S3	1.46e-04	127	28	3	30335684
Pubmed	SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.	SYT2 MAPT	1.56e-04	23	28	2	23790753
Pubmed	Biochemical and computational analysis of LNX1 interacting proteins.	PPID INKA2	3.05e-04	32	28	2	22087225
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NPHP3 PLEKHA6 MBD5 SH2B1	6.23e-04	493	28	4	15368895
Pubmed	The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome.	MAPT EIF2S3	7.78e-04	51	28	2	26269332
Interaction	ADAM29 interactions	ADAM29 PPID	1.73e-06	2	27	2	int:ADAM29
Interaction	EIF2S2 interactions	PRKCB ZC3H18 MBD5 MAPT EIF2S3	1.72e-05	247	27	5	int:EIF2S2
Interaction	TCEAL3 interactions	TCEAL3 TCEAL5	2.58e-05	6	27	2	int:TCEAL3
Cytoband	Ensembl 112 genes in cytogenetic band chrXq22	TCEAL6 TCEAL3 TCEAL5	1.58e-04	172	28	3	chrXq22
Cytoband	Xq22.1	TCEAL6 TCEAL5	3.19e-04	43	28	2	Xq22.1
Cytoband	1q32.1	SYT2 PLEKHA6	1.99e-03	108	28	2	1q32.1
Cytoband	16p11.2	PRKCB SH2B1	6.06e-03	191	28	2	16p11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr9q22	NUTM2F NUTM2G	6.63e-03	200	28	2	chr9q22
Cytoband	Ensembl 112 genes in cytogenetic band chr1q32	SYT2 PLEKHA6	1.35e-02	290	28	2	chr1q32
GeneFamily	Transcription elongation factor A like family	TCEAL6 TCEAL3 TCEAL5	8.23e-08	9	19	3	1216
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	NPHP3 PPID	6.39e-03	115	19	2	769
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHA6 SH2B1	1.94e-02	206	19	2	682
Coexpression	GSE33425_CD161_HIGH_VS_INT_CD8_TCELL_UP	PRKCB SSPN SYT2 PPID MFHAS1	1.73e-06	200	27	5	M8550
ToppCell	primary_visual_cortex-Neuronal\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PRKCB TCEAL6 TCEAL3 MAPT TCEAL5	1.35e-07	196	28	5	8efc2b3a95f57c31be203ac781b2098d4909297f
ToppCell	frontal_cortex-Neuronal\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TCEAL6 TCEAL3 MAPT TCEAL5	6.59e-06	196	28	4	de7d10da862f98894ce47244fbc992f4a12d63bb
Computational	Neighborhood of NUMA1	UPF3A LEMD3 SH2B1	7.15e-05	56	16	3	GCM_NUMA1
Disease	MEHMO syndrome (implicated_via_orthology)	EIF2S3B EIF2S3	5.81e-07	2	23	2	DOID:0060801 (implicated_via_orthology)
Disease	hypopituitarism (implicated_via_orthology)	EIF2S3B EIF2S3	8.70e-06	6	23	2	DOID:9406 (implicated_via_orthology)
Disease	leukodystrophy (implicated_via_orthology)	EIF2S3B EIF2S3	2.09e-05	9	23	2	DOID:10579 (implicated_via_orthology)
Disease	Weight decreased	ADIPOQ MAPT	1.46e-04	23	23	2	C1262477
Disease	glucose metabolism disease (implicated_via_orthology)	EIF2S3B EIF2S3	2.17e-04	28	23	2	DOID:4194 (implicated_via_orthology)
Disease	Paroxysmal atrial fibrillation	SSPN MBD5 MAPT	2.38e-04	156	23	3	C0235480
Disease	Persistent atrial fibrillation	SSPN MBD5 MAPT	2.38e-04	156	23	3	C2585653
Disease	familial atrial fibrillation	SSPN MBD5 MAPT	2.38e-04	156	23	3	C3468561
Disease	Hyperglycemia, Postprandial	PRKCB ADIPOQ	2.49e-04	30	23	2	C1855520
Disease	Hyperglycemia	PRKCB ADIPOQ	2.49e-04	30	23	2	C0020456
Disease	Atrial Fibrillation	SSPN MBD5 MAPT	2.56e-04	160	23	3	C0004238
Disease	Diabetes Mellitus	ADIPOQ EIF2S3	2.84e-04	32	23	2	C0011849
Disease	cognitive impairment measurement	SSPN MFHAS1	5.39e-04	44	23	2	EFO_0007998
Disease	feeling emotionally hurt measurement	MBD5 MAPT	8.72e-04	56	23	2	EFO_0009599
Disease	Alzheimer's disease (is_marker_for)	PRKCB ADIPOQ MAPT	1.02e-03	257	23	3	DOID:10652 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KGPDIGEVKDGTECG	ADAM29	591	Q9UKF5
DEGEDKKVRGEGPGE	ERF	506	P50548
DGRDGTPGEKGEKGD	ADIPOQ	56	Q15848
GKDVGIRCVGFGPEE	LEMD3	586	Q9Y2U8
EVCKREGGDPEEKGV	MMTAG2	101	Q9BU76
EKGGEKGETGGAREP	INKA2	176	Q9NTI7
EERVEGCPGGGDKEK	MFHAS1	431	Q9Y4C4
EGEGDLGKDSPKGEI	KIAA2026	861	Q5HYC2
GKRLGCGPEGERDIK	PRKCB	581	P05771
ALPELGGGEKECEGI	ANKRD65	381	E5RJM6
ECDGGDKEGGLPAIQ	MBD5	6	Q9P267
KPGCEVDDLKGGVAG	EIF2S3B	266	Q2VIR3
PGRKEEEEEGKGSEG	HINFP	436	Q9BQA5
GDTGEPEGQREKGKV	NUTM2F	411	A1L443
GDTGEPEGQREKGKV	NUTM2G	396	Q5VZR2
QGGEKEEPEKLGDIC	SYT2	261	Q8N9I0
ERQEKEKAGGGGVPE	SH2B1	676	Q9NRF2
GAGGGEACEIPVEVK	NPHP3	21	Q7Z494
EKPKERGEEIDTGGG	UPF3A	296	Q9H1J1
CGELKEGDDGGIFPK	PPID	181	Q08752
KGTGAPKECGEEEPR	SSPN	31	Q14714
DIEGGRGGDCPKVLV	WFDC3	161	Q8IUB2
KTRGEGDGRGCEKAE	PLEKHA6	206	Q9Y2H5
GPGDTGKDGDAEQEK	STBD1	26	O95210
KTECEGKRKAEGEPG	TCEAL6	41	Q6IPX3
GKRKAEGEPGDEGQL	TCEAL6	46	Q6IPX3
GKTECEGKREDEGEP	TCEAL5	46	Q5H9L2
AGGKERPGSKEEVDE	MAPT	206	P10636
KTECEGKREDEGEPG	TCEAL3	41	Q969E4
EEKGEGTPREEGKAG	ZC3H18	156	Q86VM9
KPGCEVDDLKGGVAG	EIF2S3	266	P41091