Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	plus-end-directed microtubule motor activity	KIF5A KIF5B KIF5C	2.48e-05	17	68	3	GO:0008574
GeneOntologyBiologicalProcess	anterograde dendritic transport of neurotransmitter receptor complex	KIF5A KIF5B KIF5C	1.19e-06	7	68	3	GO:0098971
GeneOntologyBiologicalProcess	anterograde axonal protein transport	KIF5A KIF5B KIF5C	2.84e-06	9	68	3	GO:0099641
GeneOntologyBiologicalProcess	axo-dendritic protein transport	KIF5A KIF5B KIF5C	5.55e-06	11	68	3	GO:0099640
GeneOntologyBiologicalProcess	protein localization to presynapse	KIF5A KIF5B KIF5C	5.55e-06	11	68	3	GO:1905383
GeneOntologyBiologicalProcess	anterograde dendritic transport	KIF5A KIF5B KIF5C	7.38e-06	12	68	3	GO:0098937
GeneOntologyBiologicalProcess	microtubule-based protein transport	KIF5A KIF5B KIF5C	2.25e-05	17	68	3	GO:0099118
GeneOntologyBiologicalProcess	protein transport along microtubule	KIF5A KIF5B KIF5C	2.25e-05	17	68	3	GO:0098840
GeneOntologyBiologicalProcess	dendritic transport	KIF5A KIF5B KIF5C	3.20e-05	19	68	3	GO:0098935
GeneOntologyBiologicalProcess	retrograde neuronal dense core vesicle transport	KIF5A KIF5B	1.59e-04	6	68	2	GO:1990049
GeneOntologyBiologicalProcess	ribosomal large subunit export from nucleus	SDAD1 NMD3	2.96e-04	8	68	2	GO:0000055
GeneOntologyCellularComponent	postsynaptic cytosol	PLCB3 KIF5A KIF5B KIF5C	1.38e-05	45	68	4	GO:0099524
GeneOntologyCellularComponent	ciliary rootlet	KIF5A KIF5B KIF5C	1.79e-05	16	68	3	GO:0035253
GeneOntologyCellularComponent	cytosolic region	PLCB3 KIF5A KIF5B KIF5C	7.99e-05	70	68	4	GO:0099522
GeneOntologyCellularComponent	dendrite cytoplasm	KIF5A KIF5B KIF5C	2.77e-04	39	68	3	GO:0032839
GeneOntologyCellularComponent	kinesin complex	KIF5A KIF5B KIF5C	5.45e-04	49	68	3	GO:0005871
GeneOntologyCellularComponent	chromosome, telomeric repeat region	RIF1 TERB1	9.25e-04	14	68	2	GO:0140445
Domain	ARM-type_fold	ARFGEF3 RIF1 RIC8B TERB1 IPO13 TRRAP LYST SDAD1 PPP4R3A	3.69e-06	339	68	9	IPR016024
Domain	Dystrophin	DMD UTRN	1.31e-05	2	68	2	IPR016344
Domain	DAPIN	NLRP14 NLRP8 NLRP13	6.76e-05	22	68	3	PS50824
Domain	PYRIN	NLRP14 NLRP8 NLRP13	6.76e-05	22	68	3	PF02758
Domain	DAPIN	NLRP14 NLRP8 NLRP13	6.76e-05	22	68	3	IPR004020
Domain	PYRIN	NLRP14 NLRP8 NLRP13	6.76e-05	22	68	3	SM01289
Domain	NACHT	NLRP14 NLRP8 NLRP13	7.76e-05	23	68	3	PS50837
Domain	NACHT_NTPase	NLRP14 NLRP8 NLRP13	7.76e-05	23	68	3	IPR007111
Domain	EF-hand_dom_typ1	DMD UTRN	1.94e-04	6	68	2	IPR015153
Domain	EF-hand_dom_typ2	DMD UTRN	1.94e-04	6	68	2	IPR015154
Domain	EF-hand_2	DMD UTRN	1.94e-04	6	68	2	PF09068
Domain	EF-hand_3	DMD UTRN	1.94e-04	6	68	2	PF09069
Domain	-	CFLAR NLRP14 NLRP8 NLRP13	3.68e-04	93	68	4	1.10.533.10
Domain	Kinesin_motor_CS	KIF5A KIF5B KIF5C	4.46e-04	41	68	3	IPR019821
Domain	ARM-like	RIF1 RIC8B TERB1 IPO13 TRRAP PPP4R3A	4.46e-04	270	68	6	IPR011989
Domain	DEATH-like_dom	CFLAR NLRP14 NLRP8 NLRP13	4.66e-04	99	68	4	IPR011029
Domain	Kinesin-like_fam	KIF5A KIF5B KIF5C	5.13e-04	43	68	3	IPR027640
Domain	KINESIN_MOTOR_1	KIF5A KIF5B KIF5C	5.49e-04	44	68	3	PS00411
Domain	-	KIF5A KIF5B KIF5C	5.49e-04	44	68	3	3.40.850.10
Domain	Kinesin_motor_dom	KIF5A KIF5B KIF5C	5.49e-04	44	68	3	IPR001752
Domain	Kinesin	KIF5A KIF5B KIF5C	5.49e-04	44	68	3	PF00225
Domain	KINESIN_MOTOR_2	KIF5A KIF5B KIF5C	5.49e-04	44	68	3	PS50067
Domain	KISc	KIF5A KIF5B KIF5C	5.49e-04	44	68	3	SM00129
Domain	PH_dom-like	MYO7B FRMPD1 PLCB3 LYST PREX1 PREX2 PPP4R3A	8.94e-04	426	68	7	IPR011993
Domain	P-loop_NTPase	NLRP14 ABCB10 MYO7B KIF5A KIF5B KIF5C ABCC2 NLRP8 NLRP13 EFTUD2	9.41e-04	848	68	10	IPR027417
Domain	LRR_6	NLRP14 NLRP8 NLRP13	1.06e-03	55	68	3	PF13516
Domain	-	RIF1 RIC8B TERB1 IPO13 TRRAP	1.29e-03	222	68	5	1.25.10.10
Domain	ZZ	DMD UTRN	1.92e-03	18	68	2	PF00569
Domain	ZF_ZZ_2	DMD UTRN	1.92e-03	18	68	2	PS50135
Domain	ZF_ZZ_1	DMD UTRN	1.92e-03	18	68	2	PS01357
Domain	Znf_ZZ	DMD UTRN	2.15e-03	19	68	2	IPR000433
Domain	ZnF_ZZ	DMD UTRN	2.15e-03	19	68	2	SM00291
Domain	DEP	PREX1 PREX2	2.88e-03	22	68	2	PF00610
Domain	DEP	PREX1 PREX2	2.88e-03	22	68	2	PS50186
Domain	DEP	PREX1 PREX2	2.88e-03	22	68	2	SM00049
Domain	Actinin_actin-bd_CS	DMD UTRN	3.15e-03	23	68	2	IPR001589
Domain	DEP_dom	PREX1 PREX2	3.15e-03	23	68	2	IPR000591
Domain	Spectrin	DMD UTRN	3.15e-03	23	68	2	PF00435
Domain	ACTININ_2	DMD UTRN	3.15e-03	23	68	2	PS00020
Domain	ACTININ_1	DMD UTRN	3.15e-03	23	68	2	PS00019
Domain	ABC_membrane	ABCB10 ABCC2	3.42e-03	24	68	2	PF00664
Domain	Ricin_B_lectin	GALNT2 GALNT16	3.71e-03	25	68	2	PF00652
Domain	Ubiquitin-rel_dom	MYO7B FRMPD1 USP48 GABPA	4.55e-03	184	68	4	IPR029071
Domain	ABC_TM1F	ABCB10 ABCC2	4.64e-03	28	68	2	PS50929
Domain	RICIN	GALNT2 GALNT16	4.64e-03	28	68	2	SM00458
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_ANTEROGRADE_AXONAL_TRANSPORT	KIF5A KIF5B KIF5C	2.52e-06	9	45	3	M47699
Pathway	KEGG_MEDICUS_VARIANT_OLIGOMERIC_CONFORMATION_PRPC_TO_ANTEROGRADE_AXONAL_TRANSPORT	KIF5A KIF5B KIF5C	8.50e-06	13	45	3	M47763
Pathway	KEGG_MEDICUS_REFERENCE_ANTEROGRADE_AXONAL_TRANSPORT	KIF5A KIF5B KIF5C	5.87e-05	24	45	3	M47671
Pathway	REACTOME_INSULIN_PROCESSING	KIF5A KIF5B KIF5C	6.66e-05	25	45	3	M27198
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SIFA_TO_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT	KIF5A KIF5B KIF5C	6.66e-05	25	45	3	M47775
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_ANTEROGRADE_AXONAL_TRANSPORT	KIF5A KIF5B KIF5C	6.66e-05	25	45	3	M47710
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_ANTEROGRADE_AXONAL_TRANSPORT	KIF5A KIF5B KIF5C	7.51e-05	26	45	3	M47672
Pathway	KEGG_MEDICUS_REFERENCE_ARL8_REGULATED_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT	KIF5A KIF5B KIF5C	1.85e-04	35	45	3	M47774
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_KTN1	KIF5A KIF5B	5.38e-04	11	45	2	M27490
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_KTN1	KIF5A KIF5B	5.38e-04	11	45	2	MM15218
Pathway	WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS	ABCC2 SLC51A	6.44e-04	12	45	2	M48096
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	B3GNT4 GALNT2 GALNT16	9.16e-04	60	45	3	MM15636
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	B3GNT4 GALNT2 GALNT16	1.01e-03	62	45	3	M546
Pathway	WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY	ABCC2 SLC51A	1.31e-03	17	45	2	M39666
Pubmed	Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes.	KIF5A KIF5B KIF5C	7.15e-09	3	68	3	17693257
Pubmed	Cloning and localization of a conventional kinesin motor expressed exclusively in neurons.	KIF5A KIF5B KIF5C	7.15e-09	3	68	3	7514426
Pubmed	Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons.	KIF5A KIF5B KIF5C	7.15e-09	3	68	3	30068641
Pubmed	Beta-dystrobrevin interacts directly with kinesin heavy chain in brain.	KIF5A KIF5B DMD	2.86e-08	4	68	3	14600269
Pubmed	Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites.	KIF5A KIF5B KIF5C	2.86e-08	4	68	3	11986669
Pubmed	KIF5C, a novel neuronal kinesin enriched in motor neurons.	KIF5A KIF5B KIF5C	2.86e-08	4	68	3	10964943
Pubmed	KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria.	KIF5A KIF5B KIF5C	7.13e-08	5	68	3	7528108
Pubmed	Chromosomal localization reveals three kinesin heavy chain genes in mouse.	KIF5A KIF5B KIF5C	1.42e-07	6	68	3	9782088
Pubmed	Kinesin transports RNA: isolation and characterization of an RNA-transporting granule.	KIF5A KIF5B KIF5C	2.49e-07	7	68	3	15312650
Pubmed	mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1.	KIF5A KIF5B KIF5C	2.49e-07	7	68	3	20019668
Pubmed	Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles.	KIF5A KIF5B KIF5C	2.49e-07	7	68	3	21335237
Pubmed	Analysis of Kif5b expression during mouse kidney development.	KIF5A KIF5B KIF5C	2.49e-07	7	68	3	25885434
Pubmed	Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins.	KIF5A KIF5B KIF5C	5.95e-07	9	68	3	9624122
Pubmed	Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.	KIF5A KIF5B KIF5C	8.49e-07	10	68	3	21976701
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	MED24 RIF1 BEND3 KIF5A MED23 TRRAP	9.58e-07	167	68	6	20362541
Pubmed	The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium.	KIF5A KIF5B KIF5C	1.55e-06	12	68	3	15834408
Pubmed	NODs: intracellular proteins involved in inflammation and apoptosis.	NLRP14 NLRP8 NLRP13	1.55e-06	12	68	3	12766759
Pubmed	The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos.	KIF5A KIF5B KIF5C	1.55e-06	12	68	3	16018997
Pubmed	Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.	KIF5A KIF5B KIF5C	1.55e-06	12	68	3	16301330
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP14 NLRP8 NLRP13	2.56e-06	14	68	3	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP14 NLRP8 NLRP13	2.56e-06	14	68	3	12563287
Pubmed	Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.	MED24 MED23 TRRAP	3.20e-06	15	68	3	18418385
Pubmed	Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	10525423
Pubmed	Distribution of dystrophin- and utrophin-associated protein complexes during activation of human neutrophils.	DMD UTRN	3.77e-06	2	68	2	20434517
Pubmed	Plasma lipidomic analysis shows a disease progression signature in mdx mice.	DMD UTRN	3.77e-06	2	68	2	34155298
Pubmed	In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.	DMD UTRN	3.77e-06	2	68	2	28790199
Pubmed	Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin(+/-) mice.	DMD UTRN	3.77e-06	2	68	2	24466085
Pubmed	The Angiotensin Converting Enzyme Inhibitor Lisinopril Improves Muscle Histopathology but not Contractile Function in a Mouse Model of Duchenne Muscular Dystrophy.	DMD UTRN	3.77e-06	2	68	2	27110493
Pubmed	Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin-/- mice.	DMD UTRN	3.77e-06	2	68	2	24781208
Pubmed	Isolation and characterization of a genomic clone from the murine utrophin locus.	DMD UTRN	3.77e-06	2	68	2	8268660
Pubmed	Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	25859846
Pubmed	G-utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain.	DMD UTRN	3.77e-06	2	68	2	7731967
Pubmed	Characterization of neuromuscular synapse function abnormalities in multiple Duchenne muscular dystrophy mouse models.	DMD UTRN	3.77e-06	2	68	2	27037492
Pubmed	Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue.	DMD UTRN	3.77e-06	2	68	2	16710609
Pubmed	Improvement in survival and muscle function in an mdx/utrn(-/-) double mutant mouse using a human retinal dystrophin transgene.	DMD UTRN	3.77e-06	2	68	2	16487708
Pubmed	Nonclinical Exon Skipping Studies with 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn-/- Mice Inspired by Clinical Trial Results.	DMD UTRN	3.77e-06	2	68	2	30672725
Pubmed	Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.	DMD UTRN	3.77e-06	2	68	2	21677768
Pubmed	P-Rex1 and P-Rex2 RacGEFs and cancer.	PREX1 PREX2	3.77e-06	2	68	2	28710285
Pubmed	Talin, vinculin and DRP (utrophin) concentrations are increased at mdx myotendinous junctions following onset of necrosis.	DMD UTRN	3.77e-06	2	68	2	7962191
Pubmed	Consequences of the combined deficiency in dystrophin and utrophin on the mechanical properties and myosin composition of some limb and respiratory muscles of the mouse.	DMD UTRN	3.77e-06	2	68	2	9713852
Pubmed	Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	25607927
Pubmed	Does utrophin expression in muscles of mdx mice during postnatal development functionally compensate for dystrophin deficiency?	DMD UTRN	3.77e-06	2	68	2	8021701
Pubmed	Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.	DMD UTRN	3.77e-06	2	68	2	26974331
Pubmed	Developmental studies of dystrophin-positive fibers in mdx, and DRP localization.	DMD UTRN	3.77e-06	2	68	2	8433092
Pubmed	Second-generation compound for the modulation of utrophin in the therapy of DMD.	DMD UTRN	3.77e-06	2	68	2	25935002
Pubmed	Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice.	DMD UTRN	3.77e-06	2	68	2	16024571
Pubmed	Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	28453658
Pubmed	A quantitative study of bioenergetics in skeletal muscle lacking utrophin and dystrophin.	DMD UTRN	3.77e-06	2	68	2	11801396
Pubmed	Apo-dystrophin-1 and apo-dystrophin-2, products of the Duchenne muscular dystrophy locus: expression during mouse embryogenesis and in cultured cell lines.	DMD UTRN	3.77e-06	2	68	2	7987307
Pubmed	Utility of dystrophin and utrophin staining in childhood muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	16295426
Pubmed	Comparative analysis of the human dystrophin and utrophin gene structures.	DMD UTRN	3.77e-06	2	68	2	11861579
Pubmed	Distinct mechanical properties in homologous spectrin-like repeats of utrophin.	DMD UTRN	3.77e-06	2	68	2	30914715
Pubmed	Dystrophin is a microtubule-associated protein.	DMD UTRN	3.77e-06	2	68	2	19651889
Pubmed	Skeletal muscle-specific expression of a utrophin transgene rescues utrophin-dystrophin deficient mice.	DMD UTRN	3.77e-06	2	68	2	9590295
Pubmed	Comparison of skeletal muscle pathology and motor function of dystrophin and utrophin deficient mouse strains.	DMD UTRN	3.77e-06	2	68	2	22284942
Pubmed	Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice.	DMD UTRN	3.77e-06	2	68	2	29879154
Pubmed	Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice.	DMD UTRN	3.77e-06	2	68	2	17889902
Pubmed	Identification of Dp71 isoforms in the platelet membrane cytoskeleton. Potential role in thrombin-mediated platelet adhesion.	DMD UTRN	3.77e-06	2	68	2	12370193
Pubmed	Longitudinal metabolomic analysis of plasma enables modeling disease progression in Duchenne muscular dystrophy mouse models.	DMD UTRN	3.77e-06	2	68	2	32025735
Pubmed	Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice.	DMD UTRN	3.77e-06	2	68	2	27836895
Pubmed	BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle.	DMD UTRN	3.77e-06	2	68	2	27750047
Pubmed	Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.	PREX1 PREX2	3.77e-06	2	68	2	20694145
Pubmed	Prevention of dystrophin-deficient cardiomyopathy in twenty-one-month-old carrier mice by mosaic dystrophin expression or complementary dystrophin/utrophin expression.	DMD UTRN	3.77e-06	2	68	2	17967782
Pubmed	Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.	DMD UTRN	3.77e-06	2	68	2	21062902
Pubmed	Matricellular Protein CCN5 Gene Transfer Ameliorates Cardiac and Skeletal Dysfunction in mdx/utrn (±) Haploinsufficient Mice by Reducing Fibrosis and Upregulating Utrophin Expression.	DMD UTRN	3.77e-06	2	68	2	35557546
Pubmed	Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice.	DMD UTRN	3.77e-06	2	68	2	37626761
Pubmed	Inactivating IL34 promotes regenerating muscle stem cell expansion and attenuates Duchenne muscular dystrophy in mouse models.	IL34 DMD	3.77e-06	2	68	2	37215564
Pubmed	Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration.	KIF5A KIF5B	3.77e-06	2	68	2	35259089
Pubmed	Molecular heterogeneity of the dystrophin-associated protein complex in the mouse kidney nephron: differential alterations in the absence of utrophin and dystrophin.	DMD UTRN	3.77e-06	2	68	2	15565469
Pubmed	The N- and C-Terminal Domains Differentially Contribute to the Structure and Function of Dystrophin and Utrophin Tandem Calponin-Homology Domains.	DMD UTRN	3.77e-06	2	68	2	26516677
Pubmed	Assessment of cardiac function in three mouse dystrophinopathies by magnetic resonance imaging.	DMD UTRN	3.77e-06	2	68	2	22209498
Pubmed	A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [18F]FEPPA PET.	DMD UTRN	3.77e-06	2	68	2	37108685
Pubmed	Prevention of the dystrophic phenotype in dystrophin/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene.	DMD UTRN	3.77e-06	2	68	2	10694796
Pubmed	Dystrophin and dystrophin-related protein in the central nervous system of normal controls and Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	8171962
Pubmed	Similar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice.	DMD UTRN	3.77e-06	2	68	2	27822449
Pubmed	Micro-dystrophin gene therapy prevents heart failure in an improved Duchenne muscular dystrophy cardiomyopathy mouse model.	DMD UTRN	3.77e-06	2	68	2	33651713
Pubmed	Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory.	KIF5A KIF5B	3.77e-06	2	68	2	31961321
Pubmed	Thermodynamic stability, unfolding kinetics, and aggregation of the N-terminal actin-binding domains of utrophin and dystrophin.	DMD UTRN	3.77e-06	2	68	2	22275054
Pubmed	NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.	DMD UTRN	3.77e-06	2	68	2	27798264
Pubmed	Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice.	DMD UTRN	3.77e-06	2	68	2	31506484
Pubmed	Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	9288752
Pubmed	Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	9288751
Pubmed	New approach to capture and characterize synaptic proteome.	KIF5A KIF5C	3.77e-06	2	68	2	25352669
Pubmed	Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart.	DMD UTRN	3.77e-06	2	68	2	24337461
Pubmed	Combined gene therapy via VEGF and mini-dystrophin synergistically improves pathologies in temporalis muscle of dystrophin/utrophin double knockout mice.	DMD UTRN	3.77e-06	2	68	2	33987645
Pubmed	Activation of calcineurin and stress activated protein kinase/p38-mitogen activated protein kinase in hearts of utrophin-dystrophin knockout mice.	DMD UTRN	3.77e-06	2	68	2	11297940
Pubmed	Utrophin up-regulation by artificial transcription factors induces muscle rescue and impacts the neuromuscular junction in mdx mice.	DMD UTRN	3.77e-06	2	68	2	29408646
Pubmed	Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping.	DMD UTRN	3.77e-06	2	68	2	22388933
Pubmed	Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers.	DMD UTRN	3.77e-06	2	68	2	25642938
Pubmed	Activation of non-myogenic mesenchymal stem cells during the disease progression in dystrophic dystrophin/utrophin knockout mice.	DMD UTRN	3.77e-06	2	68	2	25859011
Pubmed	Satellite cells and utrophin are not directly correlated with the degree of skeletal muscle damage in mdx mice.	DMD UTRN	3.77e-06	2	68	2	15703201
Pubmed	Microtubule binding distinguishes dystrophin from utrophin.	DMD UTRN	3.77e-06	2	68	2	24706788
Pubmed	Utrophin suppresses low frequency oscillations and coupled gating of mechanosensitive ion channels in dystrophic skeletal muscle.	DMD UTRN	3.77e-06	2	68	2	25941878
Pubmed	Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells.	KIF5A KIF5B	3.77e-06	2	68	2	1607388
Pubmed	Duchenne muscular dystrophy and the neuromuscular junction: the utrophin link.	DMD UTRN	3.77e-06	2	68	2	9297964
Pubmed	Dystrophin and utrophin do not play crucial roles in nonmuscle tissues in mice.	DMD UTRN	3.77e-06	2	68	2	10204788
Pubmed	SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.	DMD UTRN	3.77e-06	2	68	2	25652448
Pubmed	Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis.	DMD UTRN	3.77e-06	2	68	2	28785010
Pubmed	The role of proteases in excitation-contraction coupling failure in muscular dystrophy.	DMD UTRN	3.77e-06	2	68	2	25298424
Pubmed	Restoration of all dystrophin protein interactions by functional domains in trans does not rescue dystrophy.	DMD UTRN	3.77e-06	2	68	2	16307000
Interaction	MYCL interactions	KIF5A KIF5B KIF5C TRRAP	1.94e-05	48	67	4	int:MYCL
Interaction	INSYN1 interactions	BEND3 KIF5A KIF5B KIF5C DMD UTRN	2.08e-05	169	67	6	int:INSYN1
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP14 NLRP8 NLRP13	3.64e-05	25	47	3	994
GeneFamily	NLR family	NLRP14 NLRP8 NLRP13	3.64e-05	25	47	3	666
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF5A KIF5B KIF5C	2.31e-04	46	47	3	622
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	DMD UTRN	9.85e-04	18	47	2	91
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT2 GALNT16	1.22e-03	20	47	2	433
GeneFamily	Cyclins\|Mediator complex	MED24 MED23	3.32e-03	33	47	2	1061
GeneFamily	PDZ domain containing	FRMPD1 PREX1 PREX2	7.21e-03	152	47	3	1220
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO7B FRMPD1	7.48e-03	50	47	2	1293
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARFGEF3 ELL PREX2	1.16e-02	181	47	3	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PREX1 PREX2	1.28e-02	66	47	2	722
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 ATP13A4 MYO7B KIF5A DMD TEX11	3.82e-07	184	68	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 ATP13A4 MYO7B KIF5A DMD TEX11	3.82e-07	184	68	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 ATP13A4 MYO7B KIF5A DMD TEX11	3.82e-07	184	68	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARFGEF3 ATP13A4 ATP11A STK39 TMEM164 DMD	4.07e-07	186	68	6	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNCAIP CBFA2T3 UTRN LYST PREX2	9.66e-06	186	68	5	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 KIF5A KIF5C DMD RBBP8NL	1.18e-05	194	68	5	c5ef4ff73b4e51530656002e3a2fb7264cdf533d
Disease	spinal muscular atrophy (implicated_via_orthology)	KIF5A KIF5B KIF5C	9.31e-07	9	67	3	DOID:12377 (implicated_via_orthology)
Disease	motor neuron disease (implicated_via_orthology)	KIF5A KIF5B KIF5C	2.43e-06	12	67	3	DOID:231 (implicated_via_orthology)
Disease	hereditary spastic paraplegia (implicated_via_orthology)	ATP13A4 KIF5A KIF5B KIF5C	2.80e-06	43	67	4	DOID:2476 (implicated_via_orthology)
Disease	central serous retinopathy	RBBP8NL PREX1	1.41e-04	8	67	2	EFO_0009784
Disease	autosomal dominant nonsyndromic deafness (is_implicated_in)	ATP11A USP48	2.76e-04	11	67	2	DOID:0050564 (is_implicated_in)
Disease	X-21470 measurement	ABCC2 SLC51A	4.54e-04	14	67	2	EFO_0800817
Disease	Malignant neoplasm of breast	OR12D3 RIF1 NLRP14 ABCB10 KCNJ1 FRMPD1 DMD GALNT16 NLRP8	6.96e-04	1074	67	9	C0006142
Disease	exploratory eye movement measurement	UTRN NLRP8 NLRP13	8.41e-04	81	67	3	EFO_0007700
Disease	muscular dystrophy (implicated_via_orthology)	DMD UTRN	1.04e-03	21	67	2	DOID:9884 (implicated_via_orthology)
Disease	Colorectal Carcinoma	ABCB10 TMEM164 DMD ABCC2 CBFA2T3 PREX2 NLRP8	1.06e-03	702	67	7	C0009402
Disease	cholangiocarcinoma (is_implicated_in)	ABCC2 PREX2	1.14e-03	22	67	2	DOID:4947 (is_implicated_in)
Disease	blood pressure	STK39 PREX1	1.14e-03	22	67	2	EFO_0004325
Disease	autism spectrum disorder symptom	RIC8B CBFA2T3	1.25e-03	23	67	2	EFO_0005426
Disease	myeloperoxidase measurement	MED24 GALNT2	1.59e-03	26	67	2	EFO_0005243
Disease	blood rubidium measurement	RIF1 PREX1	1.59e-03	26	67	2	EFO_0021529

Protein segments in the cluster

Peptide	Gene	Start	Entry
QQLLKRVLVRKLCQP	ELL	281	P55199
PLIKLLFLPRRSRCK	CASTOR1	26	Q8WTX7
IINRAIRKPDLKVRC	ATP13A4	116	Q4VNC1
RIAIARALLKNPKIL	ABCB10	641	Q9NRK6
LARLCQKLNRLKPLE	SLC7A4	11	O43246
KLRRLQKALCLDLLS	DMD	3111	P11532
RLKRLEPCARLLEQA	CFAP73	136	A6NFT4
CLSQKLRQERKRPLL	CFLAR	426	O15519
CLLLTRIPKVKCLRN	GALNT16	171	Q8N428
LALCALRFKRKIIGL	PPP4R3A	551	Q6IN85
LRCELPKLEKRLRAT	KIF5B	856	P33176
ACNKKQLDPTRLRLI	BEND3	766	Q5T5X7
LCRCPKLRKLVLNKN	FLII	336	Q13045
ALRHPQCKLQKLLLR	NLRP8	726	Q86W28
LKKLLEPRLQCSLDA	GABPA	51	Q06546
KAAKNLELTRLLPLR	GARIN4	111	Q8IYT1
LLPRRLLISKRLAQC	DOP1B	56	Q9Y3R5
IQSRLELRKKLSCKP	GALNT2	411	Q10471
LLAISALRRCLELKP	PEX5	386	P50542
KIICNLKPALKLRLR	MED23	1316	Q9ULK4
CLGRALLRKSKILVL	ABCC2	1446	Q92887
DLLQRLLCKDPKKRL	RPS6KA4	271	O75676
PLLQRELLHCARLAK	CBFA2T3	241	O75081
LPKLLVNLVCSRRAI	OR12D3	76	Q9UGF7
CCPRLLLTRKKLQLL	SLC51A	166	Q86UW1
FLNKLCLRPDIDKIL	PLCB3	216	Q01970
KLSPKVDRLCLLNRP	RBBP8NL	281	Q8NC74
LKLVRPKALLDNCFR	IL34	156	Q6ZMJ4
LLLGCLLFLRKAAKP	B3GNT4	41	Q9C0J1
LCQLEKRKLNKAPLR	GJA9	136	P57773
DRRLVKLAPCRSLIK	FRMPD1	541	Q5SYB0
REKCLLPLQLALESK	ARFGEF3	46	Q5TH69
LLLKALVPLLKLARD	AMD1	86	P17707
LLRAALKIRICLEKQ	LYST	356	Q99698
NADLRCELPKLEKRL	KIF5A	851	Q12840
LLAQALKRKPDLFLC	IPO13	796	O94829
LQLPELAALCRRKLK	HIC2	126	Q96JB3
AIKIRRLQKALCLDL	UTRN	2866	P46939
ADLRCELPKLEKRLR	KIF5C	856	O60282
LELNLAAKLCNLLRK	RIC8B	136	Q9NVN3
LNPDILCSAKRLKLL	RIF1	306	Q5UIP0
LLKLTPLLDKADQRC	MED24	341	O75448
IQRICKYPLLLKELA	PREX1	196	Q8TCU6
PLEKRELKLARLRQL	SNCAIP	656	Q9Y6H5
KISALKACRILLREL	SPATA31E1	116	Q6ZUB1
KIILFLPCISRKLKR	STEAP2	446	Q8NFT2
CKALILLRNKNLINP	SDAD1	101	Q9NVU7
LLAKLRKDIRPECRE	NFIC	76	P08651
LLSLREELCKKLNIP	PLPBP	201	O94903
KLLHPQLACRLLELR	SPATA9	91	Q9BWV2
SLLPDVLKKVLCRQL	ATP11A	1086	P98196
CEQALLIKRRRLLSP	ZNF618	926	Q5T7W0
LCKYLLDLLRLPAKK	TMEM164	281	Q5U3C3
LLLLSICLSIRDKRK	TMEM51	76	Q9NW97
LTAVKCLLRFLLPKI	TEX11	576	Q8IYF3
LKSCLNSRKPLRVLV	PREX2	656	Q70Z35
CINKIDRLILELKLP	EFTUD2	256	Q15029
RKLLSLCLQKDPSKR	STK39	311	Q9UEW8
KQNATRKIRLLSLPC	USP48	276	Q86UV5
RKIRLLSLPCTLNLQ	USP48	281	Q86UV5
LPELQLLRGKCLRIK	TTC22	431	Q5TAA0
CNKKILLTPRRRQRL	TERB1	641	Q8NA31
LQLLRLLNPCLEKRK	TRRAP	3546	Q9Y4A5
CLPLLRKILLDLQRT	PPIP5K1	791	Q6PFW1
KLCLLIRVANLRKSL	KCNJ1	206	P48048
LCLALKNPRCKVQKL	NLRP13	746	Q86W25
ELRHPNCKLQKLLLK	NLRP14	696	Q86W24
KKPLLFDRELCLRQL	MYO7B	661	Q6PIF6
KLLAPDCSRRIQKVL	MYO7B	1761	Q6PIF6
RELLALCLKKIKAPL	NMD3	76	Q96D46