Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nitric-oxide synthase activity	NOS1 NOS2	8.94e-06	3	35	2	GO:0004517
GeneOntologyMolecularFunction	tetrahydrobiopterin binding	NOS1 NOS2	1.79e-05	4	35	2	GO:0034617
GeneOntologyMolecularFunction	endopeptidase activity	CORIN USP2 F2 PRSS12 ADAM22 CAPN15	9.21e-05	430	35	6	GO:0004175
GeneOntologyMolecularFunction	arginine binding	NOS1 NOS2	1.07e-04	9	35	2	GO:0034618
GeneOntologyMolecularFunction	manganese ion binding	MGAT5 IMPA1 ADCY2	2.60e-04	71	35	3	GO:0030145
GeneOntologyMolecularFunction	FMN binding	NOS1 NOS2	3.53e-04	16	35	2	GO:0010181
GeneOntologyMolecularFunction	peptidase activity	CORIN USP2 F2 PRSS12 ADAM22 CAPN15	8.70e-04	654	35	6	GO:0008233
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	NOS1 NOS2	2.23e-03	40	35	2	GO:0016709
GeneOntologyMolecularFunction	acetylglucosaminyltransferase activity	EOGT MGAT5	3.07e-03	47	35	2	GO:0008375
GeneOntologyMolecularFunction	lipopolysaccharide binding	F2 ADGRB1	3.20e-03	48	35	2	GO:0001530
GeneOntologyMolecularFunction	serine-type endopeptidase activity	CORIN F2 PRSS12	4.44e-03	190	35	3	GO:0004252
GeneOntologyMolecularFunction	NADP binding	NOS1 NOS2	5.28e-03	62	35	2	GO:0050661
GeneOntologyMolecularFunction	serine-type peptidase activity	CORIN F2 PRSS12	5.63e-03	207	35	3	GO:0008236
GeneOntologyMolecularFunction	hexosyltransferase activity	EOGT MGAT5 GBA2	5.94e-03	211	35	3	GO:0016758
GeneOntologyMolecularFunction	serine hydrolase activity	CORIN F2 PRSS12	6.01e-03	212	35	3	GO:0017171
GeneOntologyMolecularFunction	amino acid binding	NOS1 NOS2	7.26e-03	73	35	2	GO:0016597
GeneOntologyBiologicalProcess	positive regulation of guanylate cyclase activity	NOS1 NOS2	3.94e-05	6	34	2	GO:0031284
GeneOntologyBiologicalProcess	positive regulation of cyclase activity	NOS1 NOS2 ADCY2	6.73e-05	48	34	3	GO:0031281
GeneOntologyBiologicalProcess	positive regulation of lyase activity	NOS1 NOS2 ADCY2	7.16e-05	49	34	3	GO:0051349
GeneOntologyBiologicalProcess	regulation of guanylate cyclase activity	NOS1 NOS2	7.34e-05	8	34	2	GO:0031282
GeneOntologyBiologicalProcess	arginine catabolic process	NOS1 NOS2	1.18e-04	10	34	2	GO:0006527
GeneOntologyBiologicalProcess	regulation of cyclase activity	NOS1 NOS2 ADCY2	1.99e-04	69	34	3	GO:0031279
GeneOntologyBiologicalProcess	regulation of lyase activity	NOS1 NOS2 ADCY2	2.35e-04	73	34	3	GO:0051339
MousePheno	delayed peripheral nervous system regeneration	NOS1 NOS2	2.85e-05	4	31	2	MP:0031330
MousePheno	abnormal urine homeostasis	CORIN PRKDC EFNA4 ECI1 NOS1 NOS2 HOGA1	5.74e-05	466	31	7	MP:0009643
MousePheno	abnormal rhythmic behavior	USP2 EFNA4 IMPA1 NOS1 NOS2	7.86e-05	204	31	5	MP:0021121
MousePheno	abnormal renal/urinary system physiology	CORIN FAT4 PRKDC EFNA4 ECI1 NOS1 NOS2 HOGA1	1.02e-04	695	31	8	MP:0005502
Domain	-	NOS1 NOS2	1.02e-05	3	35	2	3.90.340.10
Domain	NOS_N	NOS1 NOS2	1.02e-05	3	35	2	IPR004030
Domain	NOS	NOS1 NOS2	1.02e-05	3	35	2	PS60001
Domain	NO_synthase	NOS1 NOS2	1.02e-05	3	35	2	PF02898
Domain	NOS_euk	NOS1 NOS2	1.02e-05	3	35	2	IPR012144
Domain	-	NOS1 NOS2	5.09e-05	6	35	2	1.20.990.10
Domain	NADPH_Cyt_P450_Rdtase_dom3	NOS1 NOS2	5.09e-05	6	35	2	IPR023173
Domain	FAD_binding_1	NOS1 NOS2	5.09e-05	6	35	2	PF00667
Domain	FAD-binding_1	NOS1 NOS2	5.09e-05	6	35	2	IPR003097
Domain	Flavdoxin-like	NOS1 NOS2	9.49e-05	8	35	2	IPR001094
Domain	FLAVODOXIN_LIKE	NOS1 NOS2	9.49e-05	8	35	2	PS50902
Domain	Flavodoxin_1	NOS1 NOS2	9.49e-05	8	35	2	PF00258
Domain	Flavodoxin/NO_synth	NOS1 NOS2	9.49e-05	8	35	2	IPR008254
Domain	Flavoprotein-like_dom	NOS1 NOS2	1.52e-04	10	35	2	IPR029039
Domain	Flavoprot_Pyr_Nucl_cyt_Rdtase	NOS1 NOS2	1.52e-04	10	35	2	IPR001709
Domain	-	NOS1 NOS2	1.52e-04	10	35	2	3.40.50.360
Domain	OxRdtase_FAD/NAD-bd	NOS1 NOS2	2.23e-04	12	35	2	IPR001433
Domain	NAD_binding_1	NOS1 NOS2	2.23e-04	12	35	2	PF00175
Domain	Kringle	F2 PRSS12	4.56e-04	17	35	2	IPR000001
Domain	Kringle	F2 PRSS12	4.56e-04	17	35	2	PF00051
Domain	KRINGLE_1	F2 PRSS12	4.56e-04	17	35	2	PS00021
Domain	Kringle_CS	F2 PRSS12	4.56e-04	17	35	2	IPR018056
Domain	KR	F2 PRSS12	4.56e-04	17	35	2	SM00130
Domain	KRINGLE_2	F2 PRSS12	4.56e-04	17	35	2	PS50070
Domain	Fd_Rdtase_FAD-bd	NOS1 NOS2	5.72e-04	19	35	2	IPR017927
Domain	FAD_FR	NOS1 NOS2	5.72e-04	19	35	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	NOS1 NOS2	5.72e-04	19	35	2	IPR017938
Domain	TRYPSIN_SER	CORIN F2 PRSS12	6.33e-04	90	35	3	IPR033116
Domain	TRYPSIN_HIS	CORIN F2 PRSS12	9.38e-04	103	35	3	IPR018114
Domain	SR	CORIN PRSS12	9.96e-04	25	35	2	SM00202
Domain	TRYPSIN_SER	CORIN F2 PRSS12	1.02e-03	106	35	3	PS00135
Domain	TRYPSIN_HIS	CORIN F2 PRSS12	1.05e-03	107	35	3	PS00134
Domain	SRCR_1	CORIN PRSS12	1.08e-03	26	35	2	PS00420
Domain	SRCR-like_dom	CORIN PRSS12	1.08e-03	26	35	2	IPR017448
Domain	SRCR_2	CORIN PRSS12	1.08e-03	26	35	2	PS50287
Domain	SRCR	CORIN PRSS12	1.16e-03	27	35	2	IPR001190
Domain	Peptidase_S1A	CORIN F2 PRSS12	1.23e-03	113	35	3	IPR001314
Domain	TRYPSIN_DOM	CORIN F2 PRSS12	1.29e-03	115	35	3	PS50240
Domain	Tryp_SPc	CORIN F2 PRSS12	1.35e-03	117	35	3	SM00020
Domain	Trypsin	CORIN F2 PRSS12	1.49e-03	121	35	3	PF00089
Domain	Trypsin_dom	CORIN F2 PRSS12	1.49e-03	121	35	3	IPR001254
Domain	Peptidase_S1_PA	CORIN F2 PRSS12	1.56e-03	123	35	3	IPR009003
Domain	Kringle-like	F2 PRSS12	1.63e-03	32	35	2	IPR013806
Pubmed	Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice.	PRKDC NOS1 NOS2	3.73e-09	4	35	3	16365445
Pubmed	Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis.	NOS1 NOS2	9.84e-07	2	35	2	14660484
Pubmed	Role of inducible or neuronal nitric oxide synthase in neurogenesis of the dentate gyrus in aged mice.	NOS1 NOS2	9.84e-07	2	35	2	21082337
Pubmed	Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.	NOS1 NOS2	9.84e-07	2	35	2	7682706
Pubmed	Pyroptotic and apoptotic cell death in iNOS and nNOS overexpressing K562 cells: A mechanistic insight.	NOS1 NOS2	9.84e-07	2	35	2	31881190
Pubmed	Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice.	NOS1 NOS2	9.84e-07	2	35	2	12646421
Pubmed	The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha.	NOS1 NOS2	9.84e-07	2	35	2	15157956
Pubmed	Effects of ethanol on neutrophil recruitment and lung host defense in nitric oxide synthase I and nitric oxide synthase II knockout mice.	NOS1 NOS2	9.84e-07	2	35	2	10512307
Pubmed	[Expression of cell adhesion molecule and nitric oxide synthase in nasal mucosa in allergic rhinitis].	NOS1 NOS2	9.84e-07	2	35	2	16780147
Pubmed	Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake.	NOS1 NOS2	9.84e-07	2	35	2	16876161
Pubmed	Chronic alcohol consumption induces an overproduction of NO by nNOS- and iNOS-expressing myenteric neurons in the murine small intestine.	NOS1 NOS2	9.84e-07	2	35	2	21470341
Pubmed	Role of nitric oxide synthase in the development of bone cancer pain and effect of L-NMMA.	NOS1 NOS2	9.84e-07	2	35	2	26648027
Pubmed	Nitric oxide synthases: roles, tolls, and controls.	NOS1 NOS2	9.84e-07	2	35	2	7522969
Pubmed	Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.	NOS1 NOS2	9.84e-07	2	35	2	28110436
Pubmed	Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases.	NOS1 NOS2	9.84e-07	2	35	2	15220315
Pubmed	Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice.	PRKDC NOS2	9.84e-07	2	35	2	11426950
Pubmed	Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.	NOS1 NOS2	9.84e-07	2	35	2	1379716
Pubmed	A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles.	NOS1 NOS2	9.84e-07	2	35	2	14976216
Pubmed	Family-based association study between NOS-I and -IIA polymorphisms and autism spectrum disorders in Korean trios.	NOS1 NOS2	9.84e-07	2	35	2	18563708
Pubmed	Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis.	NOS1 NOS2	9.84e-07	2	35	2	20655878
Pubmed	The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice.	NOS1 NOS2	9.84e-07	2	35	2	21179208
Pubmed	Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes.	NOS1 NOS2	9.84e-07	2	35	2	12738065
Pubmed	Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta.	PRKDC F2	9.84e-07	2	35	2	27442243
Pubmed	Deficiency of iNOS does not attenuate severe congestive heart failure in mice.	NOS1 NOS2	9.84e-07	2	35	2	15319210
Pubmed	Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guérin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity.	PRKDC NOS2	9.84e-07	2	35	2	17982083
Pubmed	Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder.	NOS1 NOS2	9.84e-07	2	35	2	20888049
Pubmed	Role of Nitric Oxide in Stress-Induced Anxiety: From Pathophysiology to Therapeutic Target.	NOS1 NOS2	9.84e-07	2	35	2	28061969
Pubmed	Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains.	NOS1 NOS2	9.84e-07	2	35	2	12777376
Pubmed	Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease.	NOS1 NOS2	9.84e-07	2	35	2	10581083
Pubmed	Functional variants in NOS1 and NOS2A are not associated with progressive hearing loss in Ménière's disease in a European Caucasian population.	NOS1 NOS2	9.84e-07	2	35	2	21612410
Pubmed	Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.	NOS1 NOS2	9.84e-07	2	35	2	1372907
Pubmed	Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study.	NOS1 NOS2	9.84e-07	2	35	2	17328085
Pubmed	Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.	NOS1 NOS2	9.84e-07	2	35	2	28800639
Pubmed	Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study.	NOS1 NOS2	9.84e-07	2	35	2	12490535
Pubmed	Increased nitric oxide caused by the ketogenic diet reduces the onset time of kainic acid-induced seizures in ICR mice.	NOS1 NOS2	9.84e-07	2	35	2	16460714
Pubmed	Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding.	NOS1 NOS2	9.84e-07	2	35	2	23507581
Pubmed	Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase.	NOS1 NOS2	9.84e-07	2	35	2	23904594
Pubmed	Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome.	NOS1 NOS2	2.95e-06	3	35	2	10068656
Pubmed	Molecular architecture of mammalian nitric oxide synthases.	NOS1 NOS2	2.95e-06	3	35	2	25125509
Pubmed	The gastric mucus layers: constituents and regulation of accumulation.	NOS1 NOS2	2.95e-06	3	35	2	18719000
Pubmed	Nitric oxide synthase isoforms and NF-kappaB activity in normal and osteoarthritic human chondrocytes: regulation by inducible nitric oxide.	NOS1 NOS2	2.95e-06	3	35	2	18675932
Pubmed	Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation.	NOS1 NOS2	2.95e-06	3	35	2	10484454
Pubmed	Reductase domain cysteines 1048 and 1114 are critical for catalytic activity of human endothelial cell nitric oxide synthase as probed by site-directed mutagenesis.	NOS1 NOS2	2.95e-06	3	35	2	8806629
Pubmed	Crucial roles of nitric oxide synthases in β-adrenoceptor-mediated bladder relaxation in mice.	NOS1 NOS2	2.95e-06	3	35	2	27784691
Pubmed	Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice.	NOS1 NOS2	2.95e-06	3	35	2	19580782
Pubmed	Role of NO synthase in the development of Trypanosoma cruzi-induced cardiomyopathy in mice.	NOS1 NOS2	2.95e-06	3	35	2	19407124
Pubmed	Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy.	NOS1 NOS2	2.95e-06	3	35	2	11717657
Pubmed	Estrogen induces nitric oxide production via activation of constitutive nitric oxide synthases in human neuroblastoma cells.	NOS1 NOS2	2.95e-06	3	35	2	15242984
Pubmed	Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice.	NOS1 NOS2	2.95e-06	3	35	2	14551061
Pubmed	Nitric oxide synthases and heart failure - lessons from genetically manipulated mice.	NOS1 NOS2	2.95e-06	3	35	2	23774658
Pubmed	Human immunodeficiency virus infection, inducible nitric oxide synthase expression, and microglial activation: pathogenetic relationship to the acquired immunodeficiency syndrome dementia complex.	NOS1 NOS2	2.95e-06	3	35	2	10443886
Pubmed	Mechanisms and structural determinants of HIV-1 coat protein, gp41-induced neurotoxicity.	NOS1 NOS2	2.95e-06	3	35	2	9870939
Pubmed	Severe dyslipidaemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet.	NOS1 NOS2	2.95e-06	3	35	2	20304785
Pubmed	Paradoxical roles of different nitric oxide synthase isoforms in colonic injury.	NOS1 NOS2	2.95e-06	3	35	2	14665440
Pubmed	Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease.	NOS1 NOS2	2.95e-06	3	35	2	24192154
Pubmed	Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle.	NOS1 NOS2	2.95e-06	3	35	2	17258180
Pubmed	The Functional Diversity of Nitric Oxide Synthase Isoforms in Human Nose and Paranasal Sinuses: Contrasting Pathophysiological Aspects in Nasal Allergy and Chronic Rhinosinusitis.	NOS1 NOS2	2.95e-06	3	35	2	34299181
Pubmed	Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity.	NOS1 NOS2	2.95e-06	3	35	2	15469894
Pubmed	Obesity, insulin resistance, and skeletal muscle nitric oxide synthase.	NOS1 NOS2	2.95e-06	3	35	2	22797309
Pubmed	Association between achalasia and nitric oxide synthase gene polymorphisms.	NOS1 NOS2	2.95e-06	3	35	2	16848803
Pubmed	Nitric oxide synthases: which, where, how, and why?	NOS1 NOS2	2.95e-06	3	35	2	9410890
Pubmed	Cellular and molecular mechanisms of endothelial cell dysfunction.	NOS1 NOS2	2.95e-06	3	35	2	9410891
Pubmed	Nitric oxide synthase gene polymorphisms in functional dyspepsia.	NOS1 NOS2	2.95e-06	3	35	2	24114042
Pubmed	Lessons from genetically engineered animal models. IV. Nitric oxide synthase gene knockout mice.	NOS1 NOS2	2.95e-06	3	35	2	10516139
Pubmed	Relaxation of myometrium by calcitonin gene-related peptide is independent of nitric oxide synthase activity in mouse uterus.	NOS1 NOS2	2.95e-06	3	35	2	11058547
Pubmed	Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice.	NOS1 NOS2	2.95e-06	3	35	2	10362674
Pubmed	[Polymorphic markers of the NO synthase genes and genetic predisposition to diabetic polyneuropathy in patients with type 1 diabetes mellitus].	NOS1 NOS2	2.95e-06	3	35	2	15856945
Pubmed	Genetic disruption of all NO synthase isoforms enhances BMD and bone turnover in mice in vivo: involvement of the renin-angiotensin system.	NOS1 NOS2	2.95e-06	3	35	2	18433298
Pubmed	Defective fluid and HCO(3)(-) absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice.	NOS1 NOS2	2.95e-06	3	35	2	10966931
Pubmed	Substance P enhances wound closure in nitric oxide synthase knockout mice.	NOS1 NOS2	2.95e-06	3	35	2	18952239
Pubmed	Metabolic profile and nitric oxide synthase expression of skeletal muscle fibers are altered in patients with type 1 diabetes.	NOS1 NOS2	2.95e-06	3	35	2	18465682
Pubmed	Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta.	NOS1 NOS2	2.95e-06	3	35	2	10556946
Pubmed	Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms.	NOS1 NOS2	2.95e-06	3	35	2	8995432
Pubmed	nNOS deficiency-induced cell proliferation depletes the neurogenic reserve.	NOS1 NOS2	2.95e-06	3	35	2	22027181
Pubmed	Nitric oxide synthase isoforms undertake unique roles during excitotoxicity.	NOS1 NOS2	2.95e-06	3	35	2	17446423
Pubmed	Role of nitric oxide synthase isoforms for ophthalmic artery reactivity in mice.	NOS1 NOS2	2.95e-06	3	35	2	25017185
Pubmed	Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 expression is NOS3 dependent.	NOS1 NOS2	2.95e-06	3	35	2	20953358
Pubmed	Nitric oxide synthases and protein oxidation in the quadriceps femoris of patients with chronic obstructive pulmonary disease.	NOS1 NOS2	2.95e-06	3	35	2	12816735
Pubmed	Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS-/-, and iNOS-/- mice.	NOS1 NOS2	2.95e-06	3	35	2	20581102
Pubmed	Pulmonary nitric oxide synthases and nitrotyrosine: findings during lung development and in chronic lung disease of prematurity.	NOS1 NOS2	2.95e-06	3	35	2	16950998
Pubmed	Expression profiles of NOS isoforms in gingiva of nNOS knockout mice.	NOS1 NOS2	2.95e-06	3	35	2	24657074
Pubmed	Vascular biology in genetically altered mice : smaller vessels, bigger insight.	NOS1 NOS2	2.95e-06	3	35	2	10590250
Pubmed	2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.	NOS1 NOS2	2.95e-06	3	35	2	35772285
Pubmed	Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation.	NOS1 NOS2	2.95e-06	3	35	2	25389974
Pubmed	Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period.	NOS1 NOS2	2.95e-06	3	35	2	24305053
Pubmed	Lessons learned from nitric oxide synthase knockout animals.	NOS1 NOS2	2.95e-06	3	35	2	10709868
Pubmed	Increase in Red Blood Cell-Nitric Oxide Synthase Dependent Nitric Oxide Production during Red Blood Cell Aging in Health and Disease: A Study on Age Dependent Changes of Rheologic and Enzymatic Properties in Red Blood Cells.	NOS1 NOS2	2.95e-06	3	35	2	25902315
Pubmed	Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization.	NOS1 NOS2	2.95e-06	3	35	2	25813085
Pubmed	Differential expression of nitric oxide synthases (NOS 1-3) in human skeletal muscle following exercise countermeasure during 12 weeks of bed rest.	NOS1 NOS2	2.95e-06	3	35	2	15180967
Pubmed	Alterations in nitric oxide synthase isoforms in acute lower limb ischemia and reperfusion.	NOS1 NOS2	2.95e-06	3	35	2	18024942
Pubmed	Limb reduction defects in endothelial nitric oxide synthase-deficient mice.	NOS1 NOS2	2.95e-06	3	35	2	9843834
Pubmed	Protective roles of nitric oxide and testosterone in endotoxemia: evidence from NOS-2-deficient mice.	NOS1 NOS2	2.95e-06	3	35	2	9843821
Pubmed	mRNA expressions of inducible nitric oxide synthase, endothelial nitric oxide synthase, and neuronal nitric oxide synthase genes in meningitis patients.	NOS1 NOS2	2.95e-06	3	35	2	21204701
Pubmed	Nitric oxide synthase in the vestibulocochlear system of mice.	NOS1 NOS2	2.95e-06	3	35	2	9824677
Pubmed	Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms.	NOS1 NOS2	2.95e-06	3	35	2	18413498
Pubmed	High-protein-induced glomerular hyperfiltration is independent of the tubuloglomerular feedback mechanism and nitric oxide synthases.	NOS1 NOS2	2.95e-06	3	35	2	20739607
Pubmed	Expression of nitric oxide synthase isoforms in human pregnant myometrium at term.	NOS1 NOS2	2.95e-06	3	35	2	12445599
Pubmed	Biochemistry of soluble guanylate cyclase.	NOS1 NOS2	2.95e-06	3	35	2	19089323
Pubmed	Exhaled nitric oxide production by nitric oxide synthase-deficient mice.	NOS1 NOS2	2.95e-06	3	35	2	11029328
Pubmed	Cardiovascular and renal control in NOS-deficient mouse models.	NOS1 NOS2	2.95e-06	3	35	2	12571071
Cytoband	4q28.1	FAT4 PRSS12	6.73e-05	16	35	2	4q28.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q21	ADAM22 COL1A2	8.18e-03	178	35	2	chr7q21
GeneFamily	Phosphoinositide phosphatases	IMPA1 FIG4	8.88e-04	32	25	2	1079
GeneFamily	Proteases, serine	CORIN PRSS12	3.40e-03	63	25	2	738
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 IGSF9B ADCY2 COL1A2	8.16e-06	164	35	4	e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell	(2)_Fibroblasts-(22)_Fibro-3\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	PRSS12 LHFPL1 COL1A2 SEL1L3	1.46e-05	190	35	4	3aed03b87ba2c8d479048c3ceef3ff5e38746c28
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CORIN ADCY2 ADAM22 COL1A2	1.46e-05	190	35	4	f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CORIN ADCY2 ADAM22 COL1A2	1.46e-05	190	35	4	562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CORIN ADCY2 FAM131B COL1A2	1.61e-05	195	35	4	c6bb16c0076639c6ddef1a15d8cba44bc29c077d
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CORIN ADCY2 FAM131B COL1A2	1.61e-05	195	35	4	ea89f80d3d7e9f737442f7c1aa1791d277ffc90c
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FAT4 PRSS12 ADAM22 COL1A2	1.75e-05	199	35	4	38cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	IGSF9B PRSS12 ADAM22 COL1A2	1.78e-05	200	35	4	a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Breast_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	NOS1 NOS2 ADCY2	7.02e-05	102	35	3	010b446526c0fdfde45cdc04dc2395cbbe60e820
ToppCell	COVID-19-Heart-Fib_+_CM\|Heart / Disease (COVID-19 only), tissue and cell type	VSX1 NOS1 ADCY2	7.44e-05	104	35	3	0b60a56a46f1fe3f8224ec6399d009a34a117a21
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	APBB3 FAT4 ADGRB1	1.91e-04	143	35	3	39060dc1d87505a16e2df95140087c731f099570
ToppCell	droplet-Liver-Npc-18m-Epithelial-Hepatocyte_(Midlobular)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ECI1 HOGA1 SEC14L2	2.24e-04	151	35	3	86efabf27c264c856dca1cffacb16cef52e9863c
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	NOS2 GPRASP2 COL1A2	2.42e-04	155	35	3	9d53caee196b5c2bbc90c4f54f693b64d4086065
ToppCell	367C-Lymphocytic-ILC-ILC-3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	USP2 MORN1 FAM131B	2.71e-04	161	35	3	8de421c61f4d5a6e05fdb20e4d230e2db98ee4d5
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADCY2 SLC6A20 SEL1L3	2.96e-04	166	35	3	1df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADCY2 SLC6A20 SEL1L3	2.96e-04	166	35	3	9628522e7af8f8edca733588a364ab2454ac5ca5
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CORIN PRSS12 COL1A2	3.12e-04	169	35	3	335619507857383c3b0b507cdf05d786ed59e585
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NOS1 PRSS12 COL1A2	3.34e-04	173	35	3	09a13407a41ff2cba82fc417b72bf9a24ce6c42e
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NOS1 PRSS12 COL1A2	3.34e-04	173	35	3	bfec038a6783f166240da4861e100643c6ea80a5
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT4 EOGT COL1A2	3.45e-04	175	35	3	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MGAT5 PRSS12 SEC14L2	3.45e-04	175	35	3	c227fc5d1ccb69b82a96a6354913cafaf27d0eec
ToppCell	metastatic_Brain-Endothelial_cells-Stalk-like_ECs\|Endothelial_cells / Location, Cell class and cell subclass	APBB3 NOS1 PRSS12	3.45e-04	175	35	3	f6a6db992e803d36c866a91706b02f67e0fd3e09
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CORIN FAT4 COL1A2	3.51e-04	176	35	3	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CORIN FAT4 COL1A2	3.51e-04	176	35	3	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 KLHL5 NOS1	3.57e-04	177	35	3	2b675840b7d2bb536c2c600936733bd9e97e7120
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 ADCY2 COL1A2	3.57e-04	177	35	3	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	USP2 GPRASP2 COL1A2	3.69e-04	179	35	3	ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRSS12 ADAM22 COL1A2	3.69e-04	179	35	3	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-4\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	KLHL5 ADAM22 LHFPL1	3.75e-04	180	35	3	886ebaf9cf8992e8dd13fca799a1d1a2a9ce73d8
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	CORIN ADAM22 COL1A2	3.81e-04	181	35	3	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	USP2 MGAT5 NOS1	3.94e-04	183	35	3	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS12 ADCY2 LHFPL1	3.94e-04	183	35	3	d26c7b79895de28961b8d68351f28d4bb531c75c
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRSS12 ADAM22 COL1A2	3.94e-04	183	35	3	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell-4\|TCGA-Uvea / Sample_Type by Project: Shred V9	IMPA1 PSMA3 SEL1L3	4.00e-04	184	35	3	9c56753e5e668be888662e4713cf4ce44e6c58fb
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS12 ADCY2 LHFPL1	4.00e-04	184	35	3	3da93e7d8b62463e307cc0425c47dbd3bef66799
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MGAT5 PRSS12 GPRASP2	4.00e-04	184	35	3	eeed75984ff111c0d1750df2f978163a42f20207
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MGAT5 PRSS12 GPRASP2	4.00e-04	184	35	3	3d8008f8d2e39c0d7a3cabc45620027491da03cf
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRSS12 ADAM22 COL1A2	4.06e-04	185	35	3	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRSS12 ADAM22 COL1A2	4.06e-04	185	35	3	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	COPD-Lymphoid-B\|COPD / Disease state, Lineage and Cell class	KLHL5 MGAT5 SEL1L3	4.06e-04	185	35	3	925e79c35c381dd44ec5fb921dca09ce43140135
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	USP2 MGAT5 NOS1	4.06e-04	185	35	3	898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell	COPD-Lymphoid-B\|World / Disease state, Lineage and Cell class	KLHL5 MGAT5 SEL1L3	4.06e-04	185	35	3	22891ed75e25ef30dfa541cb82d85e08ce07e7d9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	USP2 MGAT5 NOS1	4.19e-04	187	35	3	b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	USP2 MGAT5 NOS1	4.19e-04	187	35	3	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CORIN FAM131B COL1A2	4.19e-04	187	35	3	8bd635abdee5d5a12a3f7bf74eab4282e8e40741
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CORIN FAM131B COL1A2	4.19e-04	187	35	3	3cb8cd7f7a4306ff74d1f7f9964014008ec1c6a0
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CORIN IGSF9B COL1A2	4.33e-04	189	35	3	cd42ce4aa217d0bd95e0cc0ba357bdfeb3e55a48
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CORIN IGSF9B COL1A2	4.33e-04	189	35	3	102501eee7760d5882dec41ea9d00147b3f4fb73
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ADAM22 COL1A2	4.33e-04	189	35	3	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CORIN IGSF9B COL1A2	4.33e-04	189	35	3	6e83bf855d4771885b60bb8992df2f9b508eef97
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	IGSF9B VSX1 NOS1	4.39e-04	190	35	3	6c7e1086c0a274cd5527c3104106e372811c9905
ToppCell	facs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY2 FAM131B COL1A2	4.39e-04	190	35	3	c7bd087f36321cec61b98657433b4d19d135791f
ToppCell	facs-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY2 FAM131B COL1A2	4.39e-04	190	35	3	834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ADAM22 COL1A2	4.39e-04	190	35	3	445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	KLHL5 MGAT5 SEL1L3	4.39e-04	190	35	3	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ADAM22 COL1A2	4.39e-04	190	35	3	2e592323085ba9c019d678ac2a784462ab470ed9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	USP2 MGAT5 NOS1	4.39e-04	190	35	3	cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCY2 FAM131B COL1A2	4.46e-04	191	35	3	fd8331c7abdd999f55ba43d307945c6abfccbf84
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ADAM22 COL1A2	4.46e-04	191	35	3	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CORIN IGSF9B COL1A2	4.46e-04	191	35	3	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	NOS2 GPRASP2 COL1A2	4.46e-04	191	35	3	b5328733da3d3d77c4f6fc5e2ba2035f8898f172
ToppCell	facs-Lung-EPCAM-24m-Epithelial-Neuroendocrine\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAT5 GPRASP2 ADGRB1	4.46e-04	191	35	3	501d4f6ad389d9ac5051d4247b9bd3da96f713f9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ADAM22 COL1A2	4.46e-04	191	35	3	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	facs-Lung-EPCAM-24m-Epithelial-lung_neuroendocrine_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAT5 GPRASP2 ADGRB1	4.46e-04	191	35	3	8e06cc61eaff1796c2ce014074029408ba88d561
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADCY2 GPRASP2 COL1A2	4.60e-04	193	35	3	e5016959f24370579a8770787e96869f264cf7b3
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KLHL5 NOS1 ADCY2	4.60e-04	193	35	3	e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KLHL5 NOS1 ADCY2	4.60e-04	193	35	3	658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-memory_B_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MGAT5 TLE3 SEL1L3	4.67e-04	194	35	3	f0c113edb706d53792892115b67277a285219942
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM131B COL1A2 SEL1L3	4.74e-04	195	35	3	3f64e2313ec79a6d5f4013a52722d071172f6c5d
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT4 ADCY2 COL1A2	4.74e-04	195	35	3	f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM131B COL1A2 SEL1L3	4.74e-04	195	35	3	7a5108335353ac160b684650c5da97d6f7f4dbcf
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CORIN FAT4 COL1A2	4.81e-04	196	35	3	e7bfd4fb400ae0c473131d0fa306c26be08a6d03
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CORIN FAT4 COL1A2	4.81e-04	196	35	3	82fad623212d986a7fca3496faf3f8c8f5b83a11
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CORIN FAT4 COL1A2	4.81e-04	196	35	3	85e5046f774537684e1443c0fc147d562b7068d0
ToppCell	(2)_Fibroblasts-(22)_Fibro-3\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	PRSS12 LHFPL1 SEL1L3	4.88e-04	197	35	3	d9021bab82403e566ec10f78acb227c0f80b88fe
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	USP2 IGSF9B VSX1	4.88e-04	197	35	3	ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCell	COVID-19_Severe-PLT_0\|COVID-19_Severe / Disease Group and Platelet Clusters	KLHL5 SEC14L2 SEL1L3	4.88e-04	197	35	3	dbdeefa72d10f2c5f75ad5aac6f31a892d4e94a9
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT4 ADCY2 COL1A2	4.88e-04	197	35	3	6d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCell	COVID-19_Severe-PLT_0\|World / Disease Group and Platelet Clusters	KLHL5 SEC14L2 SEL1L3	4.95e-04	198	35	3	d508d69d8de233573aee14f17dd8ef054654aa54
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	USP2 MGAT5 NOS1	4.95e-04	198	35	3	4448d13511485a44fe7b549e4b8b6ad7637db624
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NOS1 ADAM22 COL1A2	5.03e-04	199	35	3	fbec5c034576cb1adaf05f6f97cc5525d19e0c1b
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PRSS12 ADAM22 COL1A2	5.03e-04	199	35	3	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PRSS12 ADAM22 COL1A2	5.03e-04	199	35	3	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	Control_saline-Hematopoietic_Myeloid-Dendritic_cells-pDC\|Control_saline / Treatment groups by lineage, cell group, cell type	ARL16 ADAM22 SEL1L3	5.03e-04	199	35	3	34b95e27581bb127e0b921e9c068dc094cb86b37
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CORIN FAT4 COL1A2	5.03e-04	199	35	3	fb580e9321ddf97c73b2e356cd82523db74a38a2
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT4 ADCY2 COL1A2	5.03e-04	199	35	3	abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PRSS12 ADAM22 COL1A2	5.10e-04	200	35	3	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CORIN ADCY2 SLC6A20	5.10e-04	200	35	3	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KLHL5 NOS1 ADCY2	5.10e-04	200	35	3	8d51b4f7b7002ee51401ebe5eaca1e8f04bfadd5
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KLHL5 ADCY2 SEL1L3	5.10e-04	200	35	3	b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	PRSS12 ADAM22 COL1A2	5.10e-04	200	35	3	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KLHL5 NOS1 ADCY2	5.10e-04	200	35	3	6a44439e4a7ce3627271375b04cfcfb9467218f4
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Fibroblasts-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	CORIN FAT4 COL1A2	5.10e-04	200	35	3	16a3685c41194a0a4a772e4eee372160263480e0
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CORIN FAT4 COL1A2	5.10e-04	200	35	3	8ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCell	Control_saline-Hematopoietic_Myeloid-Dendritic_cells\|Control_saline / Treatment groups by lineage, cell group, cell type	ARL16 ADAM22 SEL1L3	5.10e-04	200	35	3	1559844b3116d41a69081e4ee89e64744a760181
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CORIN ADCY2 SLC6A20	5.10e-04	200	35	3	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A--L4-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KLHL5 NOS1 ADCY2	5.10e-04	200	35	3	cb1f4b0d66da5b0466ff17b29e7034d451d93e4f
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PRSS12 ADAM22 COL1A2	5.10e-04	200	35	3	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	FAT4 PRSS12 COL1A2	5.10e-04	200	35	3	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PRSS12 ADAM22 COL1A2	5.10e-04	200	35	3	09537dc25f8b8b4654a7c183827ee1522a41a4e0
Drug	naBE	APBB3 NOS1 NOS2	2.23e-06	17	35	3	CID000151475
Drug	N-Omega-Propyl-L-Arginine	NOS1 NOS2	2.30e-06	2	35	2	DB02644
Drug	N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine	NOS1 NOS2	2.30e-06	2	35	2	DB03449
Drug	4-phenylimidazole	GBA2 NOS1 NOS2	6.59e-06	24	35	3	CID000069590
Drug	N-(3-(Aminomethyl)Benzyl)Acetamidine	NOS1 NOS2	6.88e-06	3	35	2	DB02044
Drug	3-Bromo-7-Nitroindazole	NOS1 NOS2	6.88e-06	3	35	2	DB01997
Drug	SQ 29,548	IMPA1 F2 NOS1 NOS2	8.67e-06	85	35	4	CID000005271
Drug	Thioperamide maleate [106243-16-7]; Up 200; 9.8uM; MCF7; HT_HG-U133A	MORN1 PRSS12 ADCY2 ADAM22 TLE3	1.04e-05	191	35	5	3392_UP
Drug	Nocloprostum	NOS1 NOS2 ADCY2	1.06e-05	28	35	3	CID006435380
Drug	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin	NOS1 NOS2	1.37e-05	4	35	2	DB02692
Drug	N-Omega-Hydroxy-L-Arginine	NOS1 NOS2	1.37e-05	4	35	2	DB03144
Drug	deuteroporphyrin	ECI1 NOS1 NOS2	1.45e-05	31	35	3	CID000067973
Drug	Y 27632	F2 NOS1 NOS2 COL1A2	1.72e-05	101	35	4	ctd:C108830
Drug	pinusolide	F2 NOS2	2.29e-05	5	35	2	CID000161721
Drug	Ha29	IMPA1 F2	2.29e-05	5	35	2	CID000132498
Drug	4-(nitroxy)butanoic acid 4-acetylaminophenyl ester	NOS1 NOS2	2.29e-05	5	35	2	ctd:C478738
Drug	phenoxybenzamine	ECI1 NOS1 NOS2 ADCY2	2.87e-05	115	35	4	CID000004768
Drug	sivelestat	PRKDC ECI1 NOS2	3.41e-05	41	35	3	CID000107706
Drug	dentatin	F2 NOS2	3.43e-05	6	35	2	CID000342801
Drug	NapNa	NOS1 NOS2	3.43e-05	6	35	2	CID000128726
Drug	N-nitroso-L-arginine	NOS1 NOS2	3.43e-05	6	35	2	CID000127762
Drug	1-hexacosanol	NOS1 NOS2	3.43e-05	6	35	2	ctd:C051942
Drug	X1207	GBA2 NOS2	3.43e-05	6	35	2	CID000084718
Drug	tricarbonyldichlororuthenium (II) dimer	F2 NOS1 NOS2	3.67e-05	42	35	3	ctd:C447082
Drug	prostacyclin sodium salt	F2 NOS1 NOS2 ADCY2 COL1A2	3.80e-05	250	35	5	CID000000159
Drug	inosose	IMPA1 ECI1	4.80e-05	7	35	2	CID000000452
Drug	AC1NLRUC	NOS1 NOS2	4.80e-05	7	35	2	CID004988604
Drug	AC1L1GI5	ECI1 NOS1 NOS2	5.15e-05	47	35	3	CID000003693
Drug	iloprost	F2 NOS1 NOS2 ADCY2	5.21e-05	134	35	4	CID005311181
Drug	Leupeptin hydrochloride	CORIN ECI1 F2 PRSS12 CAPN15	6.08e-05	276	35	5	CID000003910
Drug	WEB 2170	F2 NOS2 SLC6A20	6.21e-05	50	35	3	CID000065923
Drug	U46619	IMPA1 F2 NOS1 NOS2 ADCY2	7.08e-05	285	35	5	CID000005618
Drug	indapamide	F2 NOS2 ADCY2	7.40e-05	53	35	3	CID000003702
Drug	diethylamine	CORIN NOS1 NOS2	7.40e-05	53	35	3	CID000008021
Drug	Vi-o	NOS1 NOS2	8.21e-05	9	35	2	CID005289554
Drug	Reactive Nitrogen Species	NOS1 NOS2	8.21e-05	9	35	2	ctd:D026361
Drug	sulfur oxide	PRKDC IMPA1 ECI1	8.26e-05	55	35	3	CID000114845
Drug	citrullin	NOS1 NOS2 SEC14L2 SLC6A20	8.73e-05	153	35	4	CID000000833
Drug	verapamil	F2 NOS1 NOS2 ADCY2 SEC14L2 COL1A2	9.21e-05	490	35	6	CID000002520
Drug	TLCK	ECI1 F2 NOS2 ADCY2	9.89e-05	158	35	4	CID000004427
Drug	TEMPOL-H	PRKDC NOS2	1.03e-04	10	35	2	ctd:C505333
Drug	KMUP 1	NOS1 NOS2	1.03e-04	10	35	2	ctd:C439304
Drug	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	F2 NOS1 NOS2	1.07e-04	60	35	3	ctd:C060229
Drug	ammonia	IMPA1 ECI1 GBA2 NOS1 NOS2 SEC14L2	1.13e-04	509	35	6	CID000000222
Drug	benzoyl isothiocyanate	NOS1 NOS2	1.25e-04	11	35	2	CID000068284
Drug	guanidinoglutaric acid	NOS1 NOS2	1.25e-04	11	35	2	CID000002105
Drug	di-n-butyltin	NOS1 NOS2	1.25e-04	11	35	2	ctd:C056189
Drug	alpha-Napap	F2 NOS2	1.25e-04	11	35	2	CID005490790
Drug	cetraxate	NOS1 NOS2	1.25e-04	11	35	2	CID000002680
Drug	4-amino-1,8-naphthalimide	PRKDC NOS2	1.25e-04	11	35	2	ctd:C086538
Drug	N-(4-O-glycerol-3-methoxybenzyl)nonivamide	NOS1 NOS2	1.25e-04	11	35	2	ctd:C080418
Drug	sennosides	F2 GBA2	1.25e-04	11	35	2	CID000005199
Drug	BAEE	F2 NOS1 NOS2	1.30e-04	64	35	3	CID000123880
Drug	AC1L18QD	F2 NOS1 NOS2 ADCY2 COL1A2	1.31e-04	325	35	5	CID000000213
Drug	6-keto-prostaglandin F1 alpha	F2 NOS1 NOS2	1.36e-04	65	35	3	CID000001866
Drug	TMB-8	F2 NOS1 NOS2 ADCY2	1.50e-04	176	35	4	CID000005494
Drug	B-H-H	NOS1 NOS2	1.50e-04	12	35	2	CID000447030
Drug	L-Citrulline	NOS1 NOS2	1.50e-04	12	35	2	DB00155
Drug	thaliporphine	NOS1 NOS2	1.50e-04	12	35	2	CID000100020
Drug	Tropicamide	NOS1 NOS2	1.50e-04	12	35	2	ctd:D014331
Drug	aminoguanidine hydrochloride	NOS1 NOS2	1.77e-04	13	35	2	CID000016017
Drug	3'-AMP	APBB3 IMPA1 ADCY2	1.85e-04	72	35	3	CID000041211
Drug	methoctramine	NOS1 NOS2	2.07e-04	14	35	2	ctd:C054938
Drug	tricyclodecane-9-yl-xanthogenate	NOS2 COL1A2	2.07e-04	14	35	2	ctd:C046498
Drug	GEA 3162	NOS1 NOS2	2.07e-04	14	35	2	CID003035443
Drug	diaminoguanidine	NOS1 NOS2	2.07e-04	14	35	2	CID000151203
Drug	AC1L9T0X	NOS1 NOS2	2.07e-04	14	35	2	CID000500472
Drug	T6-7	NOS1 NOS2	2.07e-04	14	35	2	CID000216324
Drug	NG-amino-L-arginine	NOS1 NOS2	2.07e-04	14	35	2	CID000124357
Drug	kinin 9	IMPA1 F2 NOS1 NOS2 ADCY2	2.20e-04	363	35	5	CID000006026
Drug	noradrealine	IMPA1 ECI1 NOS1 NOS2 ADCY2 SLC6A20	2.20e-04	575	35	6	CID000000951
Drug	Oxamniquine [21738-42-1]; Up 200; 14.4uM; HL60; HT_HG-U133A	MGAT5 MORN1 ADCY2 ADAM22	2.22e-04	195	35	4	2924_UP
Drug	chloromethyl	ECI1 F2 NOS2 CAPN15	2.22e-04	195	35	4	CID000007835
Drug	Myosmine [532-12-7]; Up 200; 27.4uM; MCF7; HT_HG-U133A	USP2 VSX1 ADAM22 COL1A2	2.22e-04	195	35	4	3634_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A	USP2 PRSS12 ADAM22 COL1A2	2.26e-04	196	35	4	4526_UP
Drug	Foliosidine [2520-38-9]; Down 200; 13uM; MCF7; HT_HG-U133A	MORN1 ADAM22 CAPN15 SLC6A20	2.26e-04	196	35	4	6057_DN
Drug	Clofilium tosylate [92953-10-1]; Up 200; 7.8uM; MCF7; HT_HG-U133A	FAT4 MORN1 ADAM22 SLC6A20	2.31e-04	197	35	4	6830_UP
Drug	selenomethylselenocysteine	NOS2 SLC6A20 COL1A2	2.34e-04	78	35	3	ctd:C002979
Drug	Atractyloside potassium salt [102130-43-8]; Up 200; 5uM; PC3; HT_HG-U133A	MGAT5 VSX1 NOS1 NOS2	2.35e-04	198	35	4	3695_UP
Drug	Pancuronium bromide [15500-66-0]; Up 200; 5.4uM; HL60; HT_HG-U133A	EFNA4 ADAM22 CAPN15 COL1A2	2.35e-04	198	35	4	2909_UP
Drug	l956	NOS1 NOS2	2.38e-04	15	35	2	CID000017814
Drug	Bicuculline (+) [485-49-4]; Up 200; 10.8uM; HL60; HT_HG-U133A	USP2 MORN1 PRSS12 ADGRB1	2.40e-04	199	35	4	2139_UP
Drug	Iohexol [66108-95-0]; Up 200; 4.8uM; MCF7; HT_HG-U133A	MORN1 TLE3 CAPN15 SLC6A20	2.44e-04	200	35	4	3322_UP
Drug	Saquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT_HG-U133A	USP2 MGAT5 ADAM22 CAPN15	2.44e-04	200	35	4	3549_UP
Drug	Butacaine [149-16-6]; Up 200; 13uM; HL60; HT_HG-U133A	USP2 MORN1 NOS1 ADGRB1	2.44e-04	200	35	4	2728_UP
Drug	Liothyronine [6893-02-3]; Up 200; 6.2uM; HL60; HT_HG-U133A	PRSS12 ADCY2 ADAM22 SLC6A20	2.44e-04	200	35	4	2984_UP
Drug	phentolamine	ECI1 NOS1 NOS2 ADCY2	2.44e-04	200	35	4	CID000005775
Drug	rooperol	GBA2 NOS2	2.72e-04	16	35	2	CID006438989
Drug	ferutinin	NOS1 NOS2	2.72e-04	16	35	2	CID000354654
Drug	Phenytoin	PRKDC F2 NOS2 PRSS12 COL1A2	2.88e-04	385	35	5	ctd:D010672
Drug	AC1MXG3M	GBA2 NOS2	3.08e-04	17	35	2	CID003789874
Drug	N-phenylprotoporphyrin IX	NOS1 NOS2	3.08e-04	17	35	2	CID000196165
Drug	S-methylisothiourea	NOS1 NOS2	3.08e-04	17	35	2	CID000005142
Drug	7,8-diacetoxy-4-methylcoumarin	NOS1 NOS2	3.08e-04	17	35	2	ctd:C114369
Drug	Mevinphos	NOS1 NOS2	3.08e-04	17	35	2	ctd:D008799
Drug	dimemorfan	NOS1 NOS2	3.08e-04	17	35	2	ctd:C012621
Drug	3-morpholinosydnonimine (SIN-1	F2 NOS1 NOS2	3.34e-04	88	35	3	CID000005219
Drug	2,3-diaminonaphthalene	NOS1 NOS2	3.46e-04	18	35	2	CID000069872
Drug	1-TRIM	NOS1 NOS2	3.46e-04	18	35	2	CID000001359
Drug	Heme	NOS1 NOS2	3.46e-04	18	35	2	DB03014
Disease	glycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement	CORIN GBA2	2.54e-05	7	33	2	EFO_0800551
Disease	glycosyl-N-behenoyl-sphingadienine (d18:2/22:0) measurement	CORIN GBA2	2.54e-05	7	33	2	EFO_0800520
Disease	retinopathy of prematurity (biomarker_via_orthology)	NOS1 NOS2	7.95e-05	12	33	2	DOID:13025 (biomarker_via_orthology)
Disease	Hepatic Encephalopathy	PRKDC NOS1	9.39e-05	13	33	2	C0019151
Disease	Hepatic Coma	PRKDC NOS1	9.39e-05	13	33	2	C0019147
Disease	Fulminant Hepatic Failure with Cerebral Edema	PRKDC NOS1	9.39e-05	13	33	2	C0751197
Disease	Hepatic Stupor	PRKDC NOS1	9.39e-05	13	33	2	C0751198
Disease	hepatic encephalopathy (biomarker_via_orthology)	NOS1 NOS2	1.26e-04	15	33	2	DOID:13413 (biomarker_via_orthology)
Disease	chronic obstructive pulmonary disease (is_marker_for)	F2 NOS1 NOS2	1.75e-04	97	33	3	DOID:3083 (is_marker_for)
Disease	Visual seizure	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0270824
Disease	Epileptic drop attack	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0270846
Disease	Generalized seizures	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0234533
Disease	Clonic Seizures	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0234535
Disease	Vertiginous seizure	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0422855
Disease	Gustatory seizure	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0422854
Disease	Seizures, Somatosensory	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0422850
Disease	Olfactory seizure	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0422853
Disease	Seizures, Auditory	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0422852
Disease	Generalized Absence Seizures	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C4505436
Disease	Convulsive Seizures	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0751494
Disease	Seizures, Sensory	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0751496
Disease	Jacksonian Seizure	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0022333
Disease	Non-epileptic convulsion	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0751056
Disease	Atonic Absence Seizures	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0751123
Disease	Complex partial seizures	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0149958
Disease	Single Seizure	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C0751110
Disease	Epileptic Seizures	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C4317109
Disease	Nonepileptic Seizures	IMPA1 NOS1 NOS2	1.97e-04	101	33	3	C3495874
Disease	Tonic Seizures	IMPA1 NOS1 NOS2	2.03e-04	102	33	3	C0270844
Disease	Absence Seizures	IMPA1 NOS1 NOS2	2.03e-04	102	33	3	C4316903
Disease	Convulsions	IMPA1 NOS1 NOS2	2.03e-04	102	33	3	C4048158
Disease	Seizures, Focal	IMPA1 NOS1 NOS2	2.15e-04	104	33	3	C0751495
Disease	Myoclonic Seizures	IMPA1 NOS1 NOS2	2.15e-04	104	33	3	C4317123
Disease	Tonic - clonic seizures	IMPA1 NOS1 NOS2	2.15e-04	104	33	3	C0494475
Disease	COVID-19, osteoarthritis	EFNA4 SLC6A20	2.28e-04	20	33	2	MONDO_0005178, MONDO_0100096
Disease	end stage renal disease (implicated_via_orthology)	F2 NOS1	2.28e-04	20	33	2	DOID:783 (implicated_via_orthology)
Disease	alpha-tocopherol measurement	MGAT5 SEC14L2	2.28e-04	20	33	2	EFO_0007898
Disease	impotence (biomarker_via_orthology)	NOS1 NOS2	2.76e-04	22	33	2	DOID:1875 (biomarker_via_orthology)
Disease	pre-eclampsia (is_implicated_in)	CORIN F2	3.58e-04	25	33	2	DOID:10591 (is_implicated_in)
Disease	triacylglycerol 48:0 measurement	MORN1 FIG4	3.88e-04	26	33	2	EFO_0010403
Disease	Retinal Diseases	VSX1 NOS2	4.18e-04	27	33	2	C0035309
Disease	lissencephaly (implicated_via_orthology)	NOS1 NOS2	4.18e-04	27	33	2	DOID:0050453 (implicated_via_orthology)
Disease	intellectual disability (is_implicated_in)	IMPA1 PRSS12	5.17e-04	30	33	2	DOID:1059 (is_implicated_in)
Disease	neurodegenerative disease (implicated_via_orthology)	FAT4 FIG4 PSMA3	5.69e-04	145	33	3	DOID:1289 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RFGYPVCSYVDMGWT	EOGT	91	Q5NDL2
GYSTMNYCWLSLEGG	ADGRB1	1076	O14514
GFDGCIASMWYGGES	FAT4	4361	Q6V0I7
DTWSGCIMGDTGYYL	ADAM22	396	Q9P0K1
RELGGCMGPIWSSYY	ARL16	81	Q0P5N6
EGMTCYYLTHGWAGL	CAPN15	971	O75808
GSMAHCSGVTYYGLW	MORN1	191	Q5T089
GCPFNGWYMGTEIGV	NOS2	366	P35228
YGVTSWGYGCGVKDS	PRSS12	841	P56730
WGYGCGVKDSPGVYT	PRSS12	846	P56730
IMDWFGYYGGPCRAP	HOGA1	291	Q86XE5
MWRSDPCYADYGVDG	MGAT5	166	Q09328
YMVDWPGYESCQAEG	EFNA4	76	P52798
GWAYYCAGGGAAAAM	LHFPL1	166	Q86WI0
GPMYAVGGHDGWSYL	KLHL5	561	Q96PQ7
WPHSYVSQGMYCLGS	FAM131B	186	Q86XD5
GLEFSACPFSGWYMG	NOS1	581	P29475
ACPFSGWYMGTEIGV	NOS1	586	P29475
GWYMGTEIGVRDYCD	NOS1	591	P29475
TEMCGRSPAHYAGYW	ECI1	111	P42126
GYLFMCFGGTVSPWD	ADCY2	121	Q08462
SWYGGESYIQSMEPG	APBB3	101	O95704
GYYWIDPNQGCTMDA	COL1A2	1176	P08123
YDGWVTTGPSAYCGG	GBA2	676	Q9HCG7
GVFGICSEPYMKYVW	FIG4	216	Q92562
EPDTYCYITGWGHMG	CORIN	921	Q9Y5Q5
GGMCGYDLDGCPVWY	SEC14L2	86	O76054
QGGHMEGTLWCSLYY	SEL1L3	831	Q68CR1
YYEMGIHCWDVAGAG	IMPA1	211	P29218
FGPGEETNMGSWCYS	GPRASP2	196	Q96D09
GNVWRFPYLCQMYGG	SLC6A20	26	Q9NP91
WGGSSVMAEYGLYGA	VSX1	226	Q9NZR4
PGYDGGYEQTFSVWM	IGSF9B	531	Q9UPX0
MIDPSGVSYGYWGCA	PSMA3	151	P25788
GYCPTGEWLAVGMES	TLE3	666	Q04726
WSCGPAAGVIDAYMT	PRKDC	3401	P78527
GVWCYVAGKPGDFGY	F2	271	P00734
GHYTAYCRSPGTGEW	USP2	556	O75604