Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dATP binding	ST13P5 ST13	2.97e-05	5	35	2	GO:0032564
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	APOBEC3G AMPD2 ATIC	3.39e-05	36	35	3	GO:0016814
GeneOntologyMolecularFunction	adenyl deoxyribonucleotide binding	ST13P5 ST13	4.46e-05	6	35	2	GO:0032558
GeneOntologyMolecularFunction	purine deoxyribonucleotide binding	ST13P5 ST13	6.23e-05	7	35	2	GO:0032554
GeneOntologyMolecularFunction	deoxyribonucleotide binding	ST13P5 ST13	1.07e-04	9	35	2	GO:0032552
GeneOntologyMolecularFunction	actin binding	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	1.66e-04	479	35	6	GO:0003779
GeneOntologyMolecularFunction	clathrin binding	ENTHD1 EPN1 EPN2	1.82e-04	63	35	3	GO:0030276
GeneOntologyMolecularFunction	peptidoglycan binding	REG1A REG1B	5.01e-04	19	35	2	GO:0042834
GeneOntologyMolecularFunction	oligosaccharide binding	REG1A REG1B	5.56e-04	20	35	2	GO:0070492
GeneOntologyMolecularFunction	deaminase activity	APOBEC3G AMPD2	1.62e-03	34	35	2	GO:0019239
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	APOBEC3G AMPD2 ATIC	2.11e-03	146	35	3	GO:0016810
GeneOntologyMolecularFunction	molecular sequestering activity	EPN1 SQSTM1	4.80e-03	59	35	2	GO:0140313
GeneOntologyMolecularFunction	Hsp70 protein binding	ST13P5 ST13	5.45e-03	63	35	2	GO:0030544
GeneOntologyBiologicalProcess	pancreas regeneration	REG1A REG1B	2.96e-06	2	36	2	GO:1990798
GeneOntologyBiologicalProcess	positive regulation of acinar cell proliferation	REG1A REG1B	8.88e-06	3	36	2	GO:1904699
GeneOntologyBiologicalProcess	regulation of acinar cell proliferation	REG1A REG1B	2.95e-05	5	36	2	GO:1904697
GeneOntologyBiologicalProcess	negative regulation of protein refolding	ST13P5 ST13	2.95e-05	5	36	2	GO:0061084
GeneOntologyBiologicalProcess	acinar cell proliferation	REG1A REG1B	2.95e-05	5	36	2	GO:1990863
GeneOntologyBiologicalProcess	regulation of protein refolding	ST13P5 ST13	4.42e-05	6	36	2	GO:0061083
GeneOntologyBiologicalProcess	negative regulation of protein folding	ST13P5 ST13	6.19e-05	7	36	2	GO:1903333
GeneOntologyBiologicalProcess	positive regulation of type B pancreatic cell proliferation	REG1A REG1B	8.24e-05	8	36	2	GO:1904692
GeneOntologyBiologicalProcess	spermatogenesis	SPATA31C2 SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	2.58e-04	744	36	7	GO:0007283
GeneOntologyBiologicalProcess	regulation of protein folding	ST13P5 ST13	2.66e-04	14	36	2	GO:1903332
GeneOntologyBiologicalProcess	male gamete generation	SPATA31C2 SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	2.99e-04	762	36	7	GO:0048232
GeneOntologyBiologicalProcess	IMP biosynthetic process	AMPD2 ATIC	3.07e-04	15	36	2	GO:0006188
GeneOntologyBiologicalProcess	GMP biosynthetic process	AMPD2 ATIC	3.50e-04	16	36	2	GO:0006177
GeneOntologyBiologicalProcess	animal organ regeneration	REG1A REG1B ATIC	3.52e-04	79	36	3	GO:0031100
GeneOntologyBiologicalProcess	suckling behavior	REG1A REG1B	4.97e-04	19	36	2	GO:0001967
GeneOntologyBiologicalProcess	regulation of type B pancreatic cell proliferation	REG1A REG1B	6.09e-04	21	36	2	GO:0061469
GeneOntologyBiologicalProcess	purine ribonucleoside monophosphate biosynthetic process	AMPD2 ATIC	7.32e-04	23	36	2	GO:0009168
GeneOntologyBiologicalProcess	IMP metabolic process	AMPD2 ATIC	7.98e-04	24	36	2	GO:0046040
GeneOntologyBiologicalProcess	purine nucleoside monophosphate biosynthetic process	AMPD2 ATIC	8.66e-04	25	36	2	GO:0009127
GeneOntologyBiologicalProcess	AMP metabolic process	AMPD2 ATIC	1.25e-03	30	36	2	GO:0046033
GeneOntologyBiologicalProcess	protein refolding	ST13P5 ST13	1.25e-03	30	36	2	GO:0042026
GeneOntologyBiologicalProcess	positive regulation of dendrite extension	REG1A REG1B	1.33e-03	31	36	2	GO:1903861
GeneOntologyBiologicalProcess	gamete generation	SPATA31C2 SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	1.35e-03	982	36	7	GO:0007276
GeneOntologyBiologicalProcess	negative regulation of sprouting angiogenesis	EPN1 EPN2	1.42e-03	32	36	2	GO:1903671
GeneOntologyBiologicalProcess	GMP metabolic process	AMPD2 ATIC	1.51e-03	33	36	2	GO:0046037
GeneOntologyBiologicalProcess	regulation of dendrite extension	REG1A REG1B	1.70e-03	35	36	2	GO:1903859
GeneOntologyBiologicalProcess	chaperone cofactor-dependent protein refolding	ST13P5 ST13	1.70e-03	35	36	2	GO:0051085
GeneOntologyCellularComponent	acrosomal vesicle	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	1.30e-06	206	36	6	GO:0001669
GeneOntologyCellularComponent	clathrin vesicle coat	ENTHD1 EPN1 EPN2	3.80e-05	38	36	3	GO:0030125
GeneOntologyCellularComponent	secretory granule	FRK REG1A REG1B SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	4.13e-05	1014	36	9	GO:0030141
GeneOntologyCellularComponent	clathrin coat	ENTHD1 EPN1 EPN2	1.22e-04	56	36	3	GO:0030118
GeneOntologyCellularComponent	secretory vesicle	FRK REG1A REG1B SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	2.01e-04	1246	36	9	GO:0099503
GeneOntologyCellularComponent	vesicle coat	ENTHD1 EPN1 EPN2	2.08e-04	67	36	3	GO:0030120
GeneOntologyCellularComponent	membrane coat	ENTHD1 EPN1 EPN2	8.01e-04	106	36	3	GO:0030117
GeneOntologyCellularComponent	coated membrane	ENTHD1 EPN1 EPN2	8.01e-04	106	36	3	GO:0048475
GeneOntologyCellularComponent	zymogen granule	REG1A REG1B	1.38e-03	32	36	2	GO:0042588
GeneOntologyCellularComponent	clathrin-coated vesicle membrane	ENTHD1 EPN1 EPN2	2.05e-03	147	36	3	GO:0030665
GeneOntologyCellularComponent	neuronal cell body membrane	REG1A REG1B	2.49e-03	43	36	2	GO:0032809
GeneOntologyCellularComponent	cell body membrane	REG1A REG1B	2.97e-03	47	36	2	GO:0044298
GeneOntologyCellularComponent	dendrite membrane	REG1A REG1B	4.19e-03	56	36	2	GO:0032590
GeneOntologyCellularComponent	leading edge membrane	PLEK2 REG1A REG1B	5.59e-03	210	36	3	GO:0031256
MousePheno	delayed liver regeneration	REG1A REG1B	2.91e-05	6	20	2	MP:0031324
MousePheno	increased cellular sensitivity to oxidative stress	PLEK2 REG1A REG1B	3.20e-05	44	20	3	MP:0008412
Domain	DUF4599	SPATA31C2 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	2.53e-14	12	35	6	PF15371
Domain	DUF4599	SPATA31C2 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	2.53e-14	12	35	6	IPR027970
Domain	ENTH	ENTHD1 EPN1 EPN2	1.20e-07	6	35	3	PF01417
Domain	ENTH	ENTHD1 EPN1 EPN2	5.03e-07	9	35	3	PS50942
Domain	ENTH	ENTHD1 EPN1 EPN2	5.03e-07	9	35	3	SM00273
Domain	ENTH	ENTHD1 EPN1 EPN2	7.17e-07	10	35	3	IPR013809
Domain	-	ENTHD1 EPN1 EPN2	1.52e-05	26	35	3	1.25.40.90
Domain	ENTH_VHS	ENTHD1 EPN1 EPN2	2.13e-05	29	35	3	IPR008942
Domain	STI1_HS-bd	ST13P5 ST13	1.52e-04	10	35	2	IPR006636
Domain	STI1	ST13P5 ST13	1.52e-04	10	35	2	SM00727
Domain	Cytidine_deaminase-like	APOBEC3G ATIC	4.56e-04	17	35	2	IPR016193
Domain	UIM	EPN1 EPN2	5.12e-04	18	35	2	PF02809
Domain	UIM	EPN1 EPN2	7.01e-04	21	35	2	SM00726
Domain	UIM	EPN1 EPN2	9.18e-04	24	35	2	PS50330
Domain	UIM_dom	EPN1 EPN2	9.96e-04	25	35	2	IPR003903
Domain	C-type_lectin_CS	REG1A REG1B	2.94e-03	43	35	2	IPR018378
Domain	C_TYPE_LECTIN_1	REG1A REG1B	9.84e-03	80	35	2	PS00615
Domain	Lectin_C	REG1A REG1B	1.08e-02	84	35	2	PF00059
Domain	CLECT	REG1A REG1B	1.08e-02	84	35	2	SM00034
Domain	C_TYPE_LECTIN_2	REG1A REG1B	1.10e-02	85	35	2	PS50041
Domain	C-type_lectin-like	REG1A REG1B	1.13e-02	86	35	2	IPR001304
Domain	ANK	POTEJ POTEB2 POTEB	1.14e-02	251	35	3	SM00248
Domain	ANK_REPEAT	POTEJ POTEB2 POTEB	1.17e-02	253	35	3	PS50088
Domain	Ankyrin_rpt-contain_dom	POTEJ POTEB2 POTEB	1.18e-02	254	35	3	IPR020683
Domain	ANK_REP_REGION	POTEJ POTEB2 POTEB	1.18e-02	254	35	3	PS50297
Domain	TPR_1	ST13P5 ST13	1.23e-02	90	35	2	PF00515
Domain	TPR_1	ST13P5 ST13	1.23e-02	90	35	2	IPR001440
Domain	Ankyrin_rpt	POTEJ POTEB2 POTEB	1.28e-02	262	35	3	IPR002110
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	9.46e-19	6	37	6	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	9.46e-19	6	37	6	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A6 SPATA31C1 SPATA31A5 SPATA31A7	1.26e-13	24	37	6	32212159
Pubmed	POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.	POTEJ POTEB2 POTEB	6.18e-08	8	37	3	12475935
Pubmed	Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma.	REG1A REG1B	1.10e-06	2	37	2	27539087
Pubmed	Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements.	REG1A REG1B	1.10e-06	2	37	2	17463184
Pubmed	The expression of REG 1A and REG 1B is increased during acute amebic colitis.	REG1A REG1B	1.10e-06	2	37	2	21586335
Pubmed	Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats.	REG1A REG1B	1.10e-06	2	37	2	24587207
Pubmed	Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine.	REG1A REG1B	1.10e-06	2	37	2	10625646
Pubmed	Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein.	REG1A REG1B	1.10e-06	2	37	2	3541906
Pubmed	Curvature of clathrin-coated pits driven by epsin.	EPN1 EPN2	1.10e-06	2	37	2	12353027
Pubmed	Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet-Induced Obesity.	REG1A REG1B	1.10e-06	2	37	2	28009527
Pubmed	Exacerbation of indomethacin-induced small intestinal injuries in Reg I-knockout mice.	REG1A REG1B	1.10e-06	2	37	2	20508157
Pubmed	Differential expression of reg-I and reg-II genes during aging in the normal mouse.	REG1A REG1B	1.10e-06	2	37	2	8808978
Pubmed	Preferential expression of reg I beta gene in human adult pancreas.	REG1A REG1B	1.10e-06	2	37	2	11396963
Pubmed	Cellular mechanisms underlying failed beta cell regeneration in offspring of protein-restricted pregnant mice.	REG1A REG1B	1.10e-06	2	37	2	23986224
Pubmed	What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy.	REG1A REG1B	1.10e-06	2	37	2	8961348
Pubmed	Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation.	REG1A REG1B	1.10e-06	2	37	2	17898082
Pubmed	Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene.	REG1A REG1B	1.10e-06	2	37	2	2332435
Pubmed	The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic beta-cells.	REG1A REG1B	1.10e-06	2	37	2	10526060
Pubmed	Crucial role of Reg I from acinar-like cell cluster touching with islets (ATLANTIS) on mitogenesis of beta cells in EMC virus-induced diabetic mice.	REG1A REG1B	1.10e-06	2	37	2	29935186
Pubmed	Expression of Reg family genes in the gastrointestinal tract of mice treated with indomethacin.	REG1A REG1B	1.10e-06	2	37	2	25747353
Pubmed	Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice.	REG1A REG1B	1.10e-06	2	37	2	3665916
Pubmed	Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain.	REG1A REG1B	1.10e-06	2	37	2	2394826
Pubmed	Synergistic activations of REG I α and REG I β promoters by IL-6 and Glucocorticoids through JAK/STAT pathway in human pancreatic β cells.	REG1A REG1B	1.10e-06	2	37	2	25767811
Pubmed	RegII is a beta-cell protein and autoantigen in diabetes of NOD mice.	REG1A REG1B	1.10e-06	2	37	2	17192462
Pubmed	Isolation, structural determination and expression of a novel reg gene, human regI beta.	REG1A REG1B	1.10e-06	2	37	2	8110835
Pubmed	Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation.	REG1A REG1B	1.10e-06	2	37	2	8654365
Pubmed	In vivo evidence for the role of RegI in gastric regeneration: transgenic overexpression of RegI accelerates the healing of experimental gastric ulcers.	REG1A REG1B	1.10e-06	2	37	2	20157293
Pubmed	No abnormalities of reg1 alpha and reg1 beta gene associated with diabetes mellitus.	REG1A REG1B	1.10e-06	2	37	2	11796176
Pubmed	Isolation, characterization, and distribution of an unusual pancreatic human secretory protein.	REG1A REG1B	1.10e-06	2	37	2	3908481
Pubmed	Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis.	REG1A REG1B	1.10e-06	2	37	2	2525567
Pubmed	Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein.	REG1A REG1B	1.10e-06	2	37	2	3108036
Pubmed	The human reg gene encodes pancreatic stone protein.	REG1A REG1B	1.10e-06	2	37	2	2764894
Pubmed	Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions.	REG1A REG1B	1.10e-06	2	37	2	12369899
Pubmed	Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice.	REG1A REG1B	1.10e-06	2	37	2	17133485
Pubmed	Reg2 protects mouse insulinoma cells from streptozotocin-induced mitochondrial disruption and apoptosis.	REG1A REG1B	1.10e-06	2	37	2	20919961
Pubmed	A gene homologous to the reg gene is expressed in the human pancreas.	REG1A REG1B	1.10e-06	2	37	2	8348956
Pubmed	Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice.	REG1A REG1B	1.10e-06	2	37	2	20489047
Pubmed	Reg I protein in healthy and seminoma human testis.	REG1A REG1B	1.10e-06	2	37	2	18712671
Pubmed	Diabetes and tumor formation in transgenic mice expressing Reg I.	REG1A REG1B	1.10e-06	2	37	2	11097844
Pubmed	mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells.	REG1A REG1B	1.10e-06	2	37	2	25370781
Pubmed	Pancreatic regenerating gene overexpression in the nonobese diabetic mouse during active diabetogenesis.	REG1A REG1B	1.10e-06	2	37	2	8522062
Pubmed	A novel gene activated in regenerating islets.	REG1A REG1B	1.10e-06	2	37	2	2963000
Pubmed	Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome.	REG1A REG1B	1.10e-06	2	37	2	8340418
Pubmed	N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue.	REG1A REG1B	1.10e-06	2	37	2	2493268
Pubmed	Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae.	REG1A REG1B	1.10e-06	2	37	2	2226837
Pubmed	St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis.	ST13P5 ST13	1.10e-06	2	37	2	35562743
Pubmed	Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice.	REG1A REG1B	1.10e-06	2	37	2	12475793
Pubmed	Epsins Negatively Regulate Aortic Endothelial Cell Function by Augmenting Inflammatory Signaling.	EPN1 EPN2	3.30e-06	3	37	2	34440686
Pubmed	Keratinocyte Regnase-1, a Downregulator of Skin Inflammation, Contributes to Protection against Tumor Promotion by Limiting Cyclooxygenase-2 Expression.	REG1A REG1B	3.30e-06	3	37	2	36470473
Pubmed	Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells.	REG1A REG1B	3.30e-06	3	37	2	20056108
Pubmed	Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction.	REG1A REG1B	3.30e-06	3	37	2	36063729
Pubmed	Regenerating islet-derived 1α (Reg-1α) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor.	REG1A REG1B	3.30e-06	3	37	2	22158612
Pubmed	Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling.	EPN1 EPN2	3.30e-06	3	37	2	23187125
Pubmed	Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells.	REG1A REG1B	3.30e-06	3	37	2	30914711
Pubmed	Human regeneration protein/lithostathine genes map to chromosome 2p12.	REG1A REG1B	3.30e-06	3	37	2	8333731
Pubmed	A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2.	EPN1 EPN2	3.30e-06	3	37	2	28717225
Pubmed	Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to drive breast cancer development.	EPN1 EPN2	3.30e-06	3	37	2	32960814
Pubmed	Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells.	REG1A REG1B	3.30e-06	3	37	2	24801175
Pubmed	Cyclin D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration.	REG1A REG1B	3.30e-06	3	37	2	16405968
Pubmed	Loss of RegI in conjunction with gastrin deficiency in mice facilitates efficient gastric ulcer healing but is dispensable for hyperplasia and tumourigenesis.	REG1A REG1B	3.30e-06	3	37	2	19969026
Pubmed	Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays.	EPN1 SQSTM1 EPN2	5.38e-06	32	37	3	19285159
Pubmed	Role of regenerating gene I in claudin expression and barrier function in the small intestine.	REG1A REG1B	6.60e-06	4	37	2	27055226
Pubmed	Expression of Reg family proteins in embryonic stem cells and its modulation by Wnt/beta-catenin signaling.	REG1A REG1B	6.60e-06	4	37	2	20050810
Pubmed	REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation.	REG1A REG1B	6.60e-06	4	37	2	23519454
Pubmed	Regenerating (reg) and insulin genes are expressed in prepancreatic mouse embryos.	REG1A REG1B	6.60e-06	4	37	2	8863190
Pubmed	The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion.	EPN1 EPN2	6.60e-06	4	37	2	20709745
Pubmed	Reg3β deficiency impairs pancreatic tumor growth by skewing macrophage polarization.	REG1A REG1B	6.60e-06	4	37	2	23867474
Pubmed	Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency.	EPN1 EPN2	6.60e-06	4	37	2	24311377
Pubmed	Transcriptional activation of Reg2 and Reg3β genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells.	REG1A REG1B	6.60e-06	4	37	2	23147030
Pubmed	Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice.	REG1A REG1B	6.60e-06	4	37	2	22252863
Pubmed	Epsin-mediated degradation of IP3R1 fuels atherosclerosis.	EPN1 EPN2	6.60e-06	4	37	2	32770009
Pubmed	MicroRNA-7 directly targets Reg1 in pancreatic cells.	REG1A REG1B	6.60e-06	4	37	2	31166710
Pubmed	Regnase-1, an Immunomodulator, Limits the IL-36/IL-36R Autostimulatory Loop in Keratinocytes to Suppress Skin Inflammation.	REG1A REG1B	6.60e-06	4	37	2	29339122
Pubmed	Adjuvant immunotherapy increases beta cell regenerative factor Reg2 in the pancreas of diabetic mice.	REG1A REG1B	6.60e-06	4	37	2	20876350
Pubmed	Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3α, and Reg3β genes.	REG1A REG1B	6.60e-06	4	37	2	21410322
Pubmed	The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.	REG1A REG1B	6.60e-06	4	37	2	28415799
Pubmed	Identification of a novel Reg family gene, Reg IIIdelta, and mapping of all three types of Reg family gene in a 75 kilobase mouse genomic region.	REG1A REG1B	6.60e-06	4	37	2	10767532
Pubmed	Reg I-knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous structure of small intestine.	REG1A REG1B	1.10e-05	5	37	2	16909126
Pubmed	Deletion of the mouse RegIIIbeta (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons.	REG1A REG1B	1.10e-05	5	37	2	18678917
Pubmed	Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.	REG1A REG1B	1.10e-05	5	37	2	27524624
Pubmed	Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma.	REG1A REG1B	1.10e-05	5	37	2	9055810
Pubmed	Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains.	EPN1 EPN2	1.10e-05	5	37	2	9813051
Pubmed	Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.	EPN1 EPN2	1.65e-05	6	37	2	25122462
Pubmed	Reg proteins direct accumulation of functionally distinct macrophage subsets after myocardial infarction.	REG1A REG1B	1.65e-05	6	37	2	29850784
Pubmed	Mapping of 20 polymorphic DNA markers in the rat by somatic hybrid and linkage analysis.	REG1A REG1B	1.65e-05	6	37	2	8903735
Pubmed	A novel upregulation of glutathione peroxidase 1 by knockout of liver-regenerating protein Reg3β aggravates acetaminophen-induced hepatic protein nitration.	REG1A REG1B	1.65e-05	6	37	2	23811004
Pubmed	Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2.	REG1A REG1B	1.65e-05	6	37	2	23269672
Pubmed	Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes.	EPN1 EPN2	1.65e-05	6	37	2	30102256
Pubmed	Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development.	EPN1 EPN2	1.65e-05	6	37	2	25871009
Pubmed	Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.	POTEB2 POTEB	1.65e-05	6	37	2	17171436
Pubmed	Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne.	EPN1 SQSTM1 EPN2	2.10e-05	50	37	3	31699778
Pubmed	The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.	EPN1 EPN2	2.30e-05	7	37	2	18199683
Pubmed	Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.	REG1A REG1B	3.07e-05	8	37	2	34375000
Pubmed	ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development.	REG1A REG1B	3.95e-05	9	37	2	37395395
Pubmed	The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.	REG1A REG1B	3.95e-05	9	37	2	22037600
Pubmed	Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function.	EPN1 EPN2	3.95e-05	9	37	2	25314967
Pubmed	Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis.	REG1A REG1B	7.22e-05	12	37	2	18297134
Pubmed	NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.	CHD6 SQSTM1	8.53e-05	13	37	2	28416489
Interaction	ST13P5 interactions	ST13P5 SQSTM1 ST13	9.55e-07	12	34	3	int:ST13P5
Interaction	REG1B interactions	REG1A REG1B	4.13e-05	6	34	2	int:REG1B
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A5 SPATA31A7	1.76e-05	8	37	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	1.72e-04	24	37	2	9p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2p12	REG1A REG1B	9.14e-04	55	37	2	chr2p12
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	APOBEC3G ENTHD1 ST13	2.39e-03	330	37	3	chr22q13
Cytoband	2p12	REG1A REG1B	4.05e-03	117	37	2	2p12
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEJ POTEB2 POTEB	3.29e-07	13	20	3	685
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	REG1A REG1B	9.29e-04	41	20	2	1298
GeneFamily	Ankyrin repeat domain containing	POTEJ POTEB2 POTEB	2.28e-03	242	20	3	403
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder epithelial cells_emap-30875_k-means-cluster#4_top-relative-expression-ranked_1000	PLEK2 FRK GRHL1 CAPN5	1.14e-04	168	32	4	gudmap_developingLowerUrinaryTract_e13.5_bladder epithelial cells_1000_k4
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder epithelial cells_emap-30875_k-means-cluster#5_top-relative-expression-ranked_500	PLEK2 GRHL1 CAPN5	1.80e-04	73	32	3	gudmap_developingLowerUrinaryTract_e13.5_bladder epithelial cells_500_k5
Disease	renal overload-type gout	SPATA31C2 SPATA31C1	1.40e-05	6	29	2	EFO_0021525
Disease	obsolete_interleukin-1 alpha measurement	REG1A REG1B	1.95e-05	7	29	2	EFO_0802653
Disease	lithostathine-1-alpha measurement	REG1A REG1B	1.95e-05	7	29	2	EFO_0801083
Disease	eosinophil cationic protein measurement	SPATA31C2 SPATA31C1	2.60e-05	8	29	2	EFO_0010913
Disease	longitudinal alcohol consumption measurement	SPATA31C2 SPATA31C1	3.34e-05	9	29	2	EFO_0007645
Disease	egg allergy measurement, parental genotype effect measurement	SPATA31C2 SPATA31C1	7.23e-05	13	29	2	EFO_0005939, EFO_0007018
Disease	amygdala volume change measurement	SPATA31C2 SPATA31C1	1.11e-04	16	29	2	EFO_0021490
Disease	Nystagmus	REG1A REG1B	1.94e-04	21	29	2	HP_0000639
Disease	complement factor H-related protein 2 measurement	REG1A REG1B	3.72e-04	29	29	2	EFO_0600055
Disease	worry measurement	GRHL1 ST13 CRHR1	4.61e-04	154	29	3	EFO_0009589
Disease	colon cancer (biomarker_via_orthology)	REG1A REG1B	6.76e-04	39	29	2	DOID:219 (biomarker_via_orthology)
Disease	behavioural disinhibition measurement	ENTHD1 DNAH9	2.48e-03	75	29	2	EFO_0006946
Disease	response to vaccine	GPR158 DNAH9	6.40e-03	122	29	2	EFO_0004645
Disease	pursuit maintenance gain measurement	SPATA31C2 SPATA31C1	6.50e-03	123	29	2	EFO_0008433
Disease	Tinnitus	SPATA31A1 THAP12	7.23e-03	130	29	2	HP_0000360
Disease	verbal-numerical reasoning measurement	ENTHD1 GPR158	7.34e-03	131	29	2	EFO_0008394
Disease	myocardial infarction (biomarker_via_orthology)	REG1A REG1B	1.08e-02	160	29	2	DOID:5844 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RHHWWEGALDLAKKR	UMODL1-AS1	76	Q8N2C9
FHWFSKWRKLHRDQE	APOBEC3G	71	Q9HC16
HKTWEEARLHGAWTL	CAPN5	351	O15484
WDKLARWAVMHRVHS	AMPD2	551	Q01433
KWRGKAHRLLGHWEE	ST13P5	186	Q8NFI4
KWRGKAHRLLGHWEE	ST13	186	P50502
EDLDKLHRAAWWGKV	POTEB2	101	H3BUK9
MLWHRLNDHGKNWRH	ENTHD1	56	Q8IYW4
HLAADSMWHRKWVLG	NLRP8	456	Q86W28
EWFHGLRRKWRPHLH	GPR158	221	Q5T848
WKRLNDHGKNWRHVY	EPN2	61	O95208
ELHCWRIKWKHRGKD	THAP12	641	O43422
HEGWWFARHLEKRRD	FRK	76	P42685
DKSREDQLRHWKYWH	GRHL1	311	Q9NZI5
RWKDILTHGRFKWHL	CHD6	1111	Q8TD26
FTEWQHWHGAELLKR	CCDC191	406	Q8NCU4
SAIRKRWHRWQDKHS	CRHR1	401	P34998
WKRLNDHGKNWRHVY	EPN1	61	Q9Y6I3
WLSQLRHRWDDEVKH	DNAH9	1806	Q9NYC9
LWDTWKVAHLKEHRR	NOC4L	236	Q9BVI4
GLHDPKKNRRWHWSS	REG1A	101	P05451
GLHDPKKNRRWHWSS	REG1B	101	P48304
LGAHIVRFWAKHRWG	SPATA31C2	646	B4DYI2
LGAHIVRFWAKHRWG	SPATA31A6	796	Q5VVP1
EDLDKLHRAAWWGKV	POTEB	101	A0A0A6YYL3
GAHIVRFWAKHRWGL	SPATA31A7	801	Q8IWB4
EDLDKLHRAAWWGKV	POTEJ	101	P0CG39
LHRAAWWGKVARKDL	POTEJ	106	P0CG39
VLEAHIVRFWAKHRW	SPATA31C1	651	P0DKV0
HSRWLRKVKHGHFGW	SQSTM1	181	Q13501
GAHIVRFWAKHRWGL	SPATA31A3	801	Q5VYP0
LVKRGHIVHNWKARW	PLEK2	11	Q9NYT0
HRSWGLDNLHLVKDW	ZNF678	56	Q5SXM1
AWRFWHKRAEFDIHR	MIOS	706	Q9NXC5
GAHIVRFWAKHRWGL	SPATA31A1	801	Q5TZJ5
GAHIVRFWAKHRWGL	SPATA31A5	801	Q5VU36
EHVKGWWEAKDKHRI	SULT1C4	181	O75897
RLAGDKANYWWLRHH	ATIC	456	P31939