Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	RASGRF2 ARHGEF5 ITSN1 MCF2 RASGRP1 DOCK7 AKAP13 ARHGEF37 VAV1	1.72e-05	231	127	9	GO:0005085
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RASGRF2 ARHGEF5 ITSN1 MCF2 IQGAP1 RASGRP1 ARHGAP31 DOCK7 AKAP13 ARHGEF37 VAV1 ACAP3	9.63e-05	507	127	12	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RASGRF2 ARHGEF5 ITSN1 MCF2 IQGAP1 RASGRP1 ARHGAP31 DOCK7 AKAP13 ARHGEF37 VAV1 ACAP3	9.63e-05	507	127	12	GO:0030695
GeneOntologyMolecularFunction	actin filament binding	FLII MYO1E MYO1H SPTBN2 PANX1 ACTN3 IQGAP1 TLN1	1.04e-04	227	127	8	GO:0051015
GeneOntologyMolecularFunction	ornithine decarboxylase inhibitor activity	OAZ1 OAZ3	1.20e-04	3	127	2	GO:0008073
GeneOntologyMolecularFunction	phospholipid binding	FLII CEACAM5 MYO1E SPTBN2 IQGAP1 RASGRP1 SNX14 OTC KCNH1 TLN1 SMPD3 PARD3	1.99e-04	548	127	12	GO:0005543
GeneOntologyMolecularFunction	metallopeptidase activity	ADAMTS1 ERAP1 CPD CPE CPZ THOP1 ADAMDEC1	2.95e-04	200	127	7	GO:0008237
GeneOntologyMolecularFunction	ornithine decarboxylase regulator activity	OAZ1 OAZ3	3.96e-04	5	127	2	GO:0042979
GeneOntologyMolecularFunction	enzyme regulator activity	RASGRF2 ARHGEF5 ITSN1 MCF2 OAZ1 IRS1 BIRC6 DDOST LGALS3 IQGAP1 RASGRP1 ARHGAP31 ELFN1 DOCK7 ROCK1 AKAP13 ARHGEF37 OAZ3 VAV1 ACAP3	6.23e-04	1418	127	20	GO:0030234
GeneOntologyMolecularFunction	ankyrin repeat binding	KIF21A OAZ3	8.25e-04	7	127	2	GO:0071532
GeneOntologyMolecularFunction	phosphatidylinositol binding	FLII CEACAM5 MYO1E IQGAP1 SNX14 KCNH1 TLN1 PARD3	9.47e-04	316	127	8	GO:0035091
GeneOntologyMolecularFunction	metallocarboxypeptidase activity	CPD CPE CPZ	9.92e-04	31	127	3	GO:0004181
GeneOntologyMolecularFunction	metalloexopeptidase activity	ERAP1 CPD CPE CPZ	1.03e-03	70	127	4	GO:0008235
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	HSD17B7 HSD3B1	1.10e-03	8	127	2	GO:0047024
GeneOntologyMolecularFunction	3-keto sterol reductase activity	HSD17B7 HSD3B1	1.10e-03	8	127	2	GO:0000253
GeneOntologyMolecularFunction	lipid binding	FLII CEACAM5 MYO1E ARHGEF5 SPTBN2 IQGAP1 RASGRP1 SNX14 OTC KCNH1 TLN1 HSD3B1 SMPD3 PARD3 APOL2	1.54e-03	988	127	15	GO:0008289
GeneOntologyBiologicalProcess	cell junction organization	TANC2 CEACAM5 PCDHGC5 ITSN1 SPTBN2 LAMA3 CC2D1A ACTN3 LRRC4C COLQ IQGAP1 ELFN1 TLN1 DOCK7 ROCK1 PARD3 ADGRL3 TJP3	2.63e-05	974	126	18	GO:0034330
GeneOntologyBiologicalProcess	ornithine catabolic process	OAZ1 OTC	3.70e-05	2	126	2	GO:0006593
GeneOntologyCellularComponent	anchoring junction	FLII CEACAM5 MYO1E ARHGEF5 SPTBN2 LAMA3 PANX1 ACTN3 IQGAP1 ARHGAP31 TLN1 DOCK7 PARD3 VAV1 ADGRL3 BBLN TJP3	8.75e-05	976	127	17	GO:0070161
GeneOntologyCellularComponent	subapical part of cell	AKAP9 BBLN	1.09e-04	3	127	2	GO:0120219
GeneOntologyCellularComponent	cortical cytoskeleton	MYO1E SPTBN2 ACTN3 IQGAP1 PDE4DIP AKAP13	1.38e-04	129	127	6	GO:0030863
GeneOntologyCellularComponent	cortical actin cytoskeleton	MYO1E SPTBN2 ACTN3 IQGAP1 AKAP13	2.59e-04	93	127	5	GO:0030864
Domain	DH_1	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	1.84e-07	63	123	7	PS00741
Domain	RhoGEF	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	3.14e-07	68	123	7	SM00325
Domain	PH	DOK6 RASGRF2 ARHGEF5 ITSN1 SPTBN2 MCF2 IRS1 ROCK1 AKAP13 VAV1 ACAP3	3.42e-07	229	123	11	PF00169
Domain	RhoGEF	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	3.85e-07	70	123	7	PF00621
Domain	DH_2	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	3.85e-07	70	123	7	PS50010
Domain	-	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	4.24e-07	71	123	7	1.20.900.10
Domain	DH-domain	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	4.24e-07	71	123	7	IPR000219
Domain	PH	DOK6 RASGRF2 ARHGEF5 ITSN1 SPTBN2 MCF2 IRS1 ROCK1 AKAP13 VAV1 ACAP3	2.30e-06	278	123	11	SM00233
Domain	PH_DOMAIN	DOK6 RASGRF2 ARHGEF5 ITSN1 SPTBN2 MCF2 IRS1 ROCK1 AKAP13 VAV1 ACAP3	2.38e-06	279	123	11	PS50003
Domain	PH_domain	DOK6 RASGRF2 ARHGEF5 ITSN1 SPTBN2 MCF2 IRS1 ROCK1 AKAP13 VAV1 ACAP3	2.47e-06	280	123	11	IPR001849
Domain	-	DOK6 RASGRF2 ARHGEF5 ITSN1 SPTBN2 MCF2 IRS1 TLN1 ROCK1 AKAP13 VAV1 ACAP3	1.07e-05	391	123	12	2.30.29.30
Domain	PH_dom-like	DOK6 RASGRF2 ARHGEF5 ITSN1 SPTBN2 MCF2 IRS1 TLN1 ROCK1 AKAP13 VAV1 ACAP3	2.49e-05	426	123	12	IPR011993
Domain	CH	SPTBN2 ACTN3 IQGAP1 NAV3 VAV1	6.88e-05	65	123	5	SM00033
Domain	CarboxyPept_regulatory_dom	CPD CPE CPZ	7.60e-05	13	123	3	IPR014766
Domain	-	CPD CPE CPZ	7.60e-05	13	123	3	2.60.40.1120
Domain	IRS	DOK6 IRS1 TLN1	9.62e-05	14	123	3	PF02174
Domain	IRS_PTB	DOK6 IRS1 TLN1	9.62e-05	14	123	3	IPR002404
Domain	CH	SPTBN2 ACTN3 IQGAP1 NAV3 VAV1	9.81e-05	70	123	5	PF00307
Domain	-	SPTBN2 ACTN3 IQGAP1 NAV3 VAV1	1.05e-04	71	123	5	1.10.418.10
Domain	CH	SPTBN2 ACTN3 IQGAP1 NAV3 VAV1	1.20e-04	73	123	5	PS50021
Domain	GDS_CDC24_CS	ARHGEF5 ITSN1 MCF2 VAV1	1.23e-04	39	123	4	IPR001331
Domain	ODC_AZ	OAZ1 OAZ3	1.29e-04	3	123	2	IPR002993
Domain	ODC_AZ	OAZ1 OAZ3	1.29e-04	3	123	2	PF02100
Domain	ODC_AZ	OAZ1 OAZ3	1.29e-04	3	123	2	PS01337
Domain	CH-domain	SPTBN2 ACTN3 IQGAP1 NAV3 VAV1	1.36e-04	75	123	5	IPR001715
Domain	CarboxyPept-like_regulatory	CPD CPE CPZ	1.77e-04	17	123	3	IPR008969
Domain	Zn_pept	CPD CPE CPZ	2.12e-04	18	123	3	SM00631
Domain	CARBOXYPEPT_ZN_2	CPD CPE CPZ	2.50e-04	19	123	3	PS00133
Domain	CARBOXYPEPT_ZN_1	CPD CPE CPZ	2.93e-04	20	123	3	PS00132
Domain	Peptidase_M14	CPD CPE CPZ	4.48e-04	23	123	3	PF00246
Domain	Peptidase_M14	CPD CPE CPZ	4.48e-04	23	123	3	IPR000834
Domain	ZF_DAG_PE_1	RASGRP1 ROCK1 AKAP13 VAV1	8.39e-04	64	123	4	PS00479
Domain	ZF_DAG_PE_2	RASGRP1 ROCK1 AKAP13 VAV1	8.39e-04	64	123	4	PS50081
Domain	C1	RASGRP1 ROCK1 AKAP13 VAV1	8.89e-04	65	123	4	SM00109
Domain	Spectrin_repeat	SPTBN2 MCF2 ACTN3	8.99e-04	29	123	3	IPR002017
Domain	PE/DAG-bd	RASGRP1 ROCK1 AKAP13 VAV1	9.42e-04	66	123	4	IPR002219
Domain	SPEC	SPTBN2 MCF2 ACTN3	1.20e-03	32	123	3	SM00150
Domain	Spectrin/alpha-actinin	SPTBN2 MCF2 ACTN3	1.20e-03	32	123	3	IPR018159
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	RASGRF2 ARHGEF5 ITSN1 MCF2 ROCK1 AKAP13 ARHGEF37 VAV1	3.83e-08	77	93	8	MM15044
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	4.54e-08	52	93	7	MM14743
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	RASGRF2 ARHGEF5 ITSN1 MCF2 ROCK1 AKAP13 ARHGEF37 VAV1	5.19e-08	80	93	8	M800
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	1.12e-07	59	93	7	M11215
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	3.70e-07	70	93	7	MM14824
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	6.53e-07	76	93	7	M19832
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	1.41e-06	85	93	7	MM14746
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	3.43e-06	97	93	7	M9400
Pathway	REACTOME_RHOA_GTPASE_CYCLE	RASGRF2 ARHGEF5 MCF2 IQGAP1 ARHGAP31 ROCK1 AKAP13 VAV1	4.31e-06	142	93	8	MM15576
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 SMPD3 ARHGEF37 VAV1	4.31e-06	142	93	8	MM15431
Pathway	REACTOME_RHOA_GTPASE_CYCLE	RASGRF2 ARHGEF5 MCF2 IQGAP1 ARHGAP31 ROCK1 AKAP13 VAV1	6.15e-06	149	93	8	M41805
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 SMPD3 ARHGEF37 VAV1	7.85e-06	154	93	8	M27697
Pathway	REACTOME_RHO_GTPASE_CYCLE	RASGRF2 ARHGEF5 ITSN1 MCF2 CPD IQGAP1 FAM83B ARHGAP31 DOCK7 ROCK1 AKAP13 VAV1	3.04e-05	439	93	12	MM15595
Pathway	REACTOME_CDC42_GTPASE_CYCLE	RASGRF2 ARHGEF5 ITSN1 MCF2 ARHGAP31 DOCK7	3.58e-05	94	93	6	MM15598
Pathway	REACTOME_RHO_GTPASE_CYCLE	RASGRF2 ARHGEF5 ITSN1 MCF2 CPD IQGAP1 FAM83B ARHGAP31 DOCK7 ROCK1 AKAP13 VAV1	3.87e-05	450	93	12	M27078
Pathway	REACTOME_CDC42_GTPASE_CYCLE	RASGRF2 ARHGEF5 ITSN1 MCF2 IQGAP1 ARHGAP31 DOCK7	7.28e-05	155	93	7	M41808
Pathway	REACTOME_RHOC_GTPASE_CYCLE	ARHGEF5 MCF2 IQGAP1 ROCK1 AKAP13	9.68e-05	70	93	5	MM15597
Pathway	REACTOME_RHOC_GTPASE_CYCLE	ARHGEF5 MCF2 IQGAP1 ROCK1 AKAP13	1.26e-04	74	93	5	M41807
Pathway	REACTOME_RAC1_GTPASE_CYCLE	RASGRF2 ARHGEF5 MCF2 IQGAP1 ARHGAP31 DOCK7 VAV1	1.56e-04	175	93	7	MM15599
Pathway	REACTOME_RAC1_GTPASE_CYCLE	RASGRF2 ARHGEF5 MCF2 IQGAP1 ARHGAP31 DOCK7 VAV1	2.12e-04	184	93	7	M41809
Pathway	PID_RHOA_REG_PATHWAY	ARHGEF5 MCF2 AKAP13 VAV1	2.34e-04	46	93	4	M68
Pathway	BIOCARTA_RHO_PATHWAY	ARHGEF5 TLN1 ROCK1	2.92e-04	20	93	3	MM1476
Pathway	BIOCARTA_RHO_PATHWAY	ARHGEF5 TLN1 ROCK1	3.39e-04	21	93	3	M1001
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RUNX1_TO_TRANSCRIPTION	MPO RUNX1	4.25e-04	5	93	2	M49024
Pathway	REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_MYELOID_CELLS	RUNX1 LGALS3	8.85e-04	7	93	2	M27799
Pathway	WP_AGERAGE_PATHWAY	IRS1 DDOST LGALS3 ROCK1	9.36e-04	66	93	4	M39420
Pathway	PID_RAS_PATHWAY	RASGRF2 LGALS3 RASGRP1	9.92e-04	30	93	3	M269
Pathway	REACTOME_RHOB_GTPASE_CYCLE	ARHGEF5 MCF2 ROCK1 AKAP13	1.11e-03	69	93	4	MM15596
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	RASGRF2 ARHGEF5 ITSN1 MCF2 CPD IQGAP1 FAM83B ARHGAP31 DOCK7 ROCK1 AKAP13 VAV1	1.12e-03	649	93	12	MM15690
Pathway	REACTOME_RHOB_GTPASE_CYCLE	ARHGEF5 MCF2 ROCK1 AKAP13	1.17e-03	70	93	4	M41806
Pathway	REACTOME_RHOG_GTPASE_CYCLE	ARHGEF5 ITSN1 MCF2 VAV1	1.23e-03	71	93	4	MM15604
Pathway	BIOCARTA_INTEGRIN_PATHWAY	ACTN3 TLN1 ROCK1	1.31e-03	33	93	3	MM1426
Pathway	BIOCARTA_INTEGRIN_PATHWAY	ACTN3 TLN1 ROCK1	1.43e-03	34	93	3	M3342
Pathway	REACTOME_RHOG_GTPASE_CYCLE	ARHGEF5 ITSN1 MCF2 VAV1	1.44e-03	74	93	4	M41814
Pathway	PID_AVB3_INTEGRIN_PATHWAY	COL12A1 IRS1 TLN1 ROCK1	1.44e-03	74	93	4	M160
Pathway	WP_STEROID_BIOSYNTHESIS	HSD17B7 HSD3B1	1.50e-03	9	93	2	MM15903
Pathway	WP_STEROID_BIOSYNTHESIS	HSD17B7 HSD3B1	1.87e-03	10	93	2	M39538
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SOX6 FLII MYO1E ADAMTS1 KIF21A ITSN1 SPTBN2 HECTD4 OAZ1 DNAAF9 RUNX1 TRIP12 RYR3 IQGAP1 THOP1 SACS PDE4DIP NAV3 ASTN1 ZNF350 ATXN10 SMPD3 PBXIP1	3.16e-10	1285	128	23	35914814
Pubmed	Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary.	CPD CPE CPZ	4.87e-08	3	128	3	12417617
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	KIF21A ITSN1 SPTBN2 DNAH2 MAGEE2 ZC2HC1C IRS1 TRIP12 BIRC6 DDOST OTC SAMD9L TLN1 AKAP13 CFAP44	9.62e-08	736	128	15	29676528
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	MYO1E ADAMTS1 DTNA CPD CUL7 CEP78 RLIM DOCK7 PARD3 PBXIP1	2.68e-07	313	128	10	38270169
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	RASGRF2 ITSN1 MCF2 AKAP13 VAV1	2.84e-07	38	128	5	11756498
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	HSD17B7 ADAMTS1 ERAP1 SF3A1 LRRC32 CPD IRS1 SRPRB DDOST STX12 IQGAP1 ACSL4 NEU2 THOP1 AKAP9 LOXL2 TLN1 CFAP44 PBXIP1 ILVBL	3.65e-07	1451	128	20	30550785
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	RASGRF2 ITSN1 MCF2 AKAP13 VAV1	5.37e-07	43	128	5	12376548
Pubmed	A protein interaction landscape of breast cancer.	ERAP1 CDKN2AIP SPTBN2 IRS1 CUL7 RUNX1 STX12 FAM83B ACSL4 LOXL2 TLN1 TRMT1L PBXIP1	6.77e-07	634	128	13	34591612
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	TANC2 R3HDM2 CUL7 BIRC6 SRPRB FAM83B AKAP9 DOCK7 HELZ PARD3 ILVBL	8.65e-07	446	128	11	24255178
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	MYO1E DTNA SPTBN2 PANX1 CPD NDRG3 STX12 FAM83B ARHGAP31 DOCK7 ROCK1 PARD3	1.39e-06	569	128	12	30639242
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	COL12A1 RASGRF2 DTNA ACTN3 BIRC6 AKAP9 TLN1 PDE4DIP ATXN10 NOCT PARD3	2.46e-06	497	128	11	23414517
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	RASGRF2 ITSN1 MCF2 AKAP13 VAV1	2.90e-06	60	128	5	12787561
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	FLII MYO1E SF3A1 SPTBN2 CC2D1A ACTN3 TRIP12 SRPRB DDOST IQGAP1 ACSL4 AKAP9 CEP78 TLN1 DOCK7 ATXN10 PARD3 SMAD9	2.95e-06	1371	128	18	36244648
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	FLII SF3A1 KIF21A IRS1 RUNX1 TRIP12 DDOST LGALS3 IQGAP1 FAM83B THOP1 AKAP9 TLN1 UBAC2 TRMT1L PARD3 TJP3	3.47e-06	1247	128	17	27684187
Pubmed	An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.	SOX6 DOK6 LRRC4C	5.73e-06	10	128	3	20548944
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	TANC2 RASGRF2 DTNA ARHGEF5 SF3A1 ITSN1 MCF2 SRPRB DDOST ARHGAP31 TLN1 DOCK7 AKAP13 VAV1	7.57e-06	916	128	14	32203420
Pubmed	Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.	PDE4D HECTD4 RUNX1	7.86e-06	11	128	3	21642993
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ADAMTS1 DNAH2 CPD TRIP12 SRPRB DDOST STX12 IQGAP1 CEP78 TLN1 UBAC2 ATXN10 HEATR5B ILVBL	1.04e-05	942	128	14	31073040
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	DTNA SF3A1 CC2D1A CPD SRPRB DDOST IQGAP1 FAM83B TLN1 DOCK7 ROCK1 PARD3	1.28e-05	708	128	12	39231216
Pubmed	Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity.	RUNX1 RASGRP1	1.34e-05	2	128	2	33065764
Pubmed	Precystectomy serum levels of carbohydrate antigen 19-9, carbohydrate antigen 125, and carcinoembryonic antigen: prognostic value in invasive urothelial carcinoma of the bladder.	CEACAM5 MUC16	1.34e-05	2	128	2	24680660
Pubmed	Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase.	PDE4D PDE4DIP	1.34e-05	2	128	2	11134006
Pubmed	Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells.	IRS1 ROCK1	1.34e-05	2	128	2	11739394
Pubmed	Trajectories of Perioperative Serum Tumor Markers and Colorectal Cancer Outcomes: A Retrospective, Multicenter Longitudinal Cohort Study.	CEACAM5 MUC16	1.34e-05	2	128	2	34801967
Pubmed	RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses.	RASGRF2 VAV1	1.34e-05	2	128	2	17923690
Pubmed	Genetic variants in ACTN3 and MYO1H are associated with sagittal and vertical craniofacial skeletal patterns.	MYO1H ACTN3	1.34e-05	2	128	2	30366217
Pubmed	Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma.	MCF2 VAV1	1.34e-05	2	128	2	31416844
Pubmed	14-3-3 proteins regulate cullin 7-mediated Eag1 degradation.	CUL7 KCNH1	1.34e-05	2	128	2	36717938
Pubmed	Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells.	CPD CPE	1.34e-05	2	128	2	21628999
Pubmed	Galectin-3 expression in pituitary adenomas as a marker of aggressive behavior.	RUNX1 LGALS3	1.34e-05	2	128	2	24007691
Pubmed	Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure.	MUC16 LGALS3	1.34e-05	2	128	2	25875367
Pubmed	Cdc42 GTPase-activating protein (CdGAP) interacts with the SH3D domain of Intersectin through a novel basic-rich motif.	ITSN1 ARHGAP31	1.34e-05	2	128	2	21349274
Pubmed	Polyamines in spermiogenesis: not now, darling.	OAZ1 OAZ3	1.34e-05	2	128	2	10781034
Pubmed	Immunohistochemical localization of carboxypeptidases E and D in the human placenta and umbilical cord.	CPD CPE	1.34e-05	2	128	2	9815277
Pubmed	Significance of serum tumor marker levels in peritoneal carcinomatosis of appendiceal origin.	CEACAM5 MUC16	1.34e-05	2	128	2	22941175
Pubmed	The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin.	ITSN1 ARHGAP31	1.34e-05	2	128	2	11744688
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BDP1 FLII RASGRF2 CDKN2AIP SPTBN2 TRIP12 SRPRB RYR3 SNX14 RP1	1.64e-05	497	128	10	36774506
Pubmed	Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells.	FLII TLN1 PARD3	1.72e-05	14	128	3	34361001
Pubmed	Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.	CUL7 TRIP12 IQGAP1 HELZ	1.76e-05	42	128	4	7584044
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	PDE4D SPTBN2 LAMA3 AKR1A1 TRIP12 DDOST IQGAP1 NEU2 DOCK7 NAV3 HELZ TRMT1L	1.77e-05	732	128	12	34732716
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	TANC2 PDE4D RASGRF2 SPTBN2 HECTD4 DOCK7	1.83e-05	147	128	6	16959763
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	MYO1E CDKN2AIP SF3A1 ARMC10 DDOST SACS DOCK7 ROCK1 TRMT1L	1.84e-05	400	128	9	35013556
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TANC2 FLII DTNA CPZ LRRC4C NDRG3 BIRC6 SRPRB ELFN1 PDE4DIP DOCK7 NAV3 HELZ ASTN1 ADGRL3	2.04e-05	1139	128	15	36417873
Pubmed	Hereditary Ataxia Overview	SPTBN2 SNX14 SACS ZFHX3 ATXN10	2.38e-05	92	128	5	20301317
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLII SF3A1 SPTBN2 CUL7 TRIP12 SRPRB DDOST IQGAP1 FAM83B SACS TLN1 DOCK7 ATXN10 HEATR5B	2.61e-05	1024	128	14	24711643
Pubmed	Defining the membrane proteome of NK cells.	ERAP1 CC2D1A PANX1 CPD BIRC6 DDOST LGALS3 ACSL4 HELZ AKAP13 ATXN10 HEATR5B APOL2 ILVBL PRPH	2.72e-05	1168	128	15	19946888
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TSHZ3 ARHGEF5 ITSN1 TRIP12 ARHGAP31 TLN1 AKAP13 LDLRAD4 ADGRL3	3.24e-05	430	128	9	35044719
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DTNA SF3A1 ITSN1 SPTBN2 CC2D1A CPD SRPRB DDOST FAM83B AKAP9 SACS TLN1 CDK5RAP1 AKAP13 ATXN10 PARD3 PBXIP1	3.36e-05	1487	128	17	33957083
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	FLII ARMC10 R3HDM2 CPD CUL7 BIRC6 SRPRB DDOST FAM83B ACSL4 OTC AKAP9 CDK5RAP1 SASS6 UBAC2 ATXN10 APOL2	3.62e-05	1496	128	17	32877691
Pubmed	Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.	FLII IQGAP1	4.02e-05	3	128	2	32432944
Pubmed	DDOST, PRKCSH and LGALS3, which encode AGE-receptors 1, 2 and 3, respectively, are not associated with diabetic nephropathy in type 1 diabetes.	DDOST LGALS3	4.02e-05	3	128	2	20490454
Pubmed	Serum concentrations of CA 125, CA 15-3, CA 19-9 and CEA in normal pregnancy: a longitudinal study.	CEACAM5 MUC16	4.02e-05	3	128	2	21792548
Pubmed	Carboxypeptidase E in the mouse placenta.	CPD CPE	4.02e-05	3	128	2	17177860
Pubmed	PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.	PDE4D AKAP9	4.02e-05	3	128	2	22908311
Pubmed	Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit.	OAZ1 OAZ3	4.02e-05	3	128	2	10954585
Pubmed	Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells.	SOX6 TRIP12	4.02e-05	3	128	2	23663701
Pubmed	Role of the small GTPase activating protein IQGAP1 in collagen phagocytosis.	FLII IQGAP1	4.02e-05	3	128	2	32643295
Pubmed	Effect of freeze-thaw cycles on serum measurements of AFP, CEA, CA125 and CA19-9.	CEACAM5 MUC16	4.02e-05	3	128	2	17852813
Pubmed	Molecular Pathway of Microtubule Organization at the Golgi Apparatus.	AKAP9 PDE4DIP	4.02e-05	3	128	2	27666745
Pubmed	Association of Preoperative Serum Levels of CEA and CA15-3 with Molecular Subtypes of Breast Cancer.	CEACAM5 MUC16	4.02e-05	3	128	2	34621407
Pubmed	Phase II trial and prediction of response of single agent tipifarnib in patients with relapsed/refractory mantle cell lymphoma: a Groupe d'Etude des Lymphomes de l'Adulte trial.	RASGRP1 AKAP13	4.02e-05	3	128	2	19960345
Pubmed	Regulation of all members of the antizyme family by antizyme inhibitor.	OAZ1 OAZ3	4.02e-05	3	128	2	15355308
Pubmed	Clinical Evaluation of Tumor Markers for Diagnosis in Patients with Non-small Cell Lung Cancer in China.	CEACAM5 MUC16	4.02e-05	3	128	2	26163610
Pubmed	Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors.	IQGAP1 SAMD9L	4.02e-05	3	128	2	26078295
Pubmed	RN1, a novel galectin-3 inhibitor, inhibits pancreatic cancer cell growth in vitro and in vivo via blocking galectin-3 associated signaling pathways.	RUNX1 LGALS3	4.02e-05	3	128	2	27617577
Pubmed	Preoperative serum carbohydrate antigen 125 level is an independent negative prognostic marker for overall survival in colorectal cancer.	CEACAM5 MUC16	4.02e-05	3	128	2	20373053
Pubmed	A novel model for extrapleural cavity metastasis assessment in patients with lung cancer.	CEACAM5 MUC16	4.02e-05	3	128	2	33709781
Pubmed	The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1).	MPO RUNX1	4.02e-05	3	128	2	8384306
Pubmed	RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors.	RUNX1 LGALS3	4.02e-05	3	128	2	19020999
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	DTNA ITSN1 CPD SRPRB DDOST STX12 TLN1 DOCK7 UBAC2	4.52e-05	449	128	9	31732153
Pubmed	The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.	HSD17B7 CRLF1 ARMC10 CUL7 SRPRB DDOST PDE4DIP RP1 ATXN10	4.84e-05	453	128	9	27113764
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	BDP1 DTNA RADX ITSN1 CUL7 FAM83B SASS6 HELZ ROCK1 CFAP44	6.73e-05	588	128	10	38580884
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	HECTD4 IQGAP1 ACSL4 TLN1 AKAP13 PARD3	7.67e-05	190	128	6	15161933
Pubmed	Clinical value of p53, c-erbB-2, CEA and CA125 regarding relapse, metastasis and death in resectable non-small cell lung cancer.	CEACAM5 MUC16	8.02e-05	4	128	2	14566828
Pubmed	GARP: a key receptor controlling FOXP3 in human regulatory T cells.	LRRC32 LGALS3	8.02e-05	4	128	2	19453521
Pubmed	Developmental origin of lung macrophage diversity.	RUNX1 LGALS3	8.02e-05	4	128	2	26952982
Pubmed	Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.	ITSN1 ACTN3	8.02e-05	4	128	2	28161632
Pubmed	The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.	RASGRF2 VAV1	8.02e-05	4	128	2	20011522
Pubmed	Clinical evaluation and therapeutic monitoring value of serum tumor markers in lung cancer.	CEACAM5 MUC16	8.02e-05	4	128	2	26560853
Pubmed	ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1.	OAZ1 OAZ3	8.02e-05	4	128	2	18062773
Pubmed	The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3.	PDE4D AKAP9	8.02e-05	4	128	2	19218243
Pubmed	Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier.	MUC16 LGALS3	8.02e-05	4	128	2	19556244
Pubmed	Clinical Performance of CEA, CA19-9, CA15-3, CA125 and AFP in Gastrointestinal Cancer Using LOCI™-based Assays.	CEACAM5 MUC16	8.02e-05	4	128	2	28011514
Pubmed	Genetic modifiers interact with Cpe(fat) to affect body weight, adiposity, and hyperglycemia.	CPD CPE	8.02e-05	4	128	2	15870393
Pubmed	Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3-dependent keratinocyte motility.	LAMA3 LGALS3	8.02e-05	4	128	2	19940114
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLII PDE4D TRIP12 IQGAP1 DOCK7 AKAP13	1.07e-04	202	128	6	33005030
Pubmed	TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.	ARMC10 SRPRB DDOST ILVBL	1.12e-04	67	128	4	35670107
Pubmed	Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.	ROCK1 PARD3	1.33e-04	5	128	2	21685893
Pubmed	The efficacy of serum carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 15-3 (CA15-3), alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG) levels in determining the malignancy of solitary pulmonary nodules.	CEACAM5 MUC16	1.33e-04	5	128	2	19383238
Pubmed	Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes.	IRS1 CUL7	1.33e-04	5	128	2	29269414
Pubmed	Reference intervals for carcinoembryonic antigen (CEA), CA125, MUC1, Alfa-foeto-protein (AFP), neuron-specific enolase (NSE) and CA19.9 from the NORIP study.	CEACAM5 MUC16	1.33e-04	5	128	2	18609108
Pubmed	Sex-dependent differences in Rho activation contribute to contractile dysfunction in type 2 diabetic mice.	DOCK7 ROCK1	1.33e-04	5	128	2	19666843
Pubmed	ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.	LGALS3 HSD3B1	1.33e-04	5	128	2	23874215
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	R3HDM2 LRRC4C AKAP9 TLN1 PDE4DIP DOCK7 NAV3 ADGRL3	1.38e-04	407	128	8	12693553
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	MUC16 CC2D1A NDRG3 TRIP12 BIRC6 SRPRB FAM83B DOCK7 UBAC2 ZFHX3 PARD3	1.47e-04	777	128	11	35844135
Pubmed	Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.	ARHGEF5 ITSN1 VAV1	1.49e-04	28	128	3	18067320
Pubmed	SOSTDC1 promotes invasion and liver metastasis in colorectal cancer via interaction with ALCAM/CD166.	CEACAM5 DOCK7 ATXN10	1.49e-04	28	128	3	32801337
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	FLII ITSN1 SPTBN2 ARMC10 CC2D1A CPD RASGRP1 SNX14 TLN1 UBAC2 LDLRAD4 SMAD9	1.65e-04	925	128	12	28986522
Pubmed	Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice.	OAZ1 HSD3B1 OAZ3	1.66e-04	29	128	3	18583422
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	FLII RADX ARHGEF5 BIRC6 AKAP9	1.69e-04	139	128	5	25476789
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF2 ARHGEF5 ITSN1 MCF2 AKAP13 ARHGEF37 VAV1	2.67e-08	66	86	7	722
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DOK6 RASGRF2 ITSN1 SPTBN2 IRS1 ROCK1 AKAP13 VAV1 ACAP3	5.85e-07	206	86	9	682
GeneFamily	Carboxypeptidases	CPD CPE CPZ	1.30e-04	21	86	3	1321
GeneFamily	Myosins, class I	MYO1E MYO1H	6.15e-04	8	86	2	1097
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	TSHZ3 ZFHX3	2.26e-03	15	86	2	529
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	BDP1 ERAP1 SF3A1 HECTD4 OAZ1 TRIP12 BIRC6 IQGAP1 ACSL4 RASGRP1 SAMD9L AKAP9 SACS TLN1 PDE4DIP HELZ ROCK1 AKAP13 PBXIP1 LDLRAD4 VAV1 BBLN	2.77e-06	1492	127	22	M40023
Coexpression	BUSSLINGER_DUODENAL_IMMUNE_CELLS	PDE4D OAZ1 TRIP12 IQGAP1 RASGRP1 SAMD9L SACS TLN1 HELZ ROCK1 UBAC2 AKAP13 PBXIP1 LDLRAD4 VAV1 BBLN	8.83e-06	911	127	16	M40038
Coexpression	ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN	PCDHGC5 DTNA LAMA3 RUNX1 LGALS3 PDE4DIP ZFHX3 APOL2	1.32e-05	222	127	8	M16955
Coexpression	CUI_TCF21_TARGETS_2_DN	COL12A1 PDE4D MYO1E DTNA ITSN1 MCF2 IRS1 ACSL4 ARHGAP31 LOXL2 PDE4DIP ROCK1 NOCT HEATR5B ADGRL3	1.72e-05	854	127	15	M1533
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	TANC2 PDE4D DTNA KIF21A HECTD4 IRS1 DNAAF9 LRRC4C SAMD9L CEP78 DOCK7 NAV3 SASS6 HELZ ASTN1 ZFHX3 ADGRL3	2.42e-05	1102	127	17	M2369
Coexpression	CUI_TCF21_TARGETS_2_DN	COL12A1 PDE4D MYO1E DTNA ITSN1 MCF2 IRS1 ACSL4 ARHGAP31 LOXL2 PDE4DIP ROCK1 NOCT HEATR5B ADGRL3	2.70e-05	888	127	15	MM1018
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	TANC2 PDE4D DTNA KIF21A HECTD4 IRS1 DNAAF9 LRRC4C SAMD9L CEP78 DOCK7 NAV3 SASS6 HELZ ASTN1 ZFHX3 ADGRL3	3.10e-05	1124	127	17	MM1070
Coexpression	GSE46606_IRF4HIGH_VS_IRF4MID_CD40L_IL2_IL5_DAY1_STIMULATED_BCELL_DN	MYO1E ZC2HC1C RASGRP1 SAMD9L HSD3B1 HEATR5B PRPH	5.59e-05	200	127	7	M9844
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	ITSN1 R3HDM2 IRS1 RUNX1 TRIP12 ACSL4 AKAP9 SACS NAV3 HELZ ROCK1 AKAP13 ZFHX3 PARD3	7.19e-05	856	127	14	M4500
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 KIF21A SPTBN2 MUC16 CPD LGALS3 CAPN13 CFAP44 TJP3	5.59e-09	197	127	9	5c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCell	(2)_5-FU-(4)_COL2.3+_osteoblasts\|(2)_5-FU / Stress and Cell class	SOX6 MYO1E KIF21A LGALS3 LOXL2 PDE4DIP ZFHX3 SMPD3	5.24e-08	181	127	8	56ae86072858c156681507aecd1bc6cb0a3372d2
ToppCell	(3)_Chondrocytes\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	SOX6 COL12A1 KIF21A CPE LGALS3 SUSD5 PDE4DIP SMPD3	8.26e-08	192	127	8	5d2b4830d025d3dbdf5623ce1c28d1036e1984a8
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BDP1 TRIP12 BIRC6 SAMD9L AKAP9 HELZ ROCK1 AKAP13	1.13e-07	200	127	8	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	PDE4D MYO1E DTNA LAMA3 RYR3 ROCK1 ADGRL3	1.16e-06	188	127	7	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 MCF2 SUSD5 ASTN1 ZFHX3 ADGRL3 SMAD9	1.21e-06	189	127	7	032f169e8ede653117919bf97c17f92043320b3c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 MCF2 SUSD5 ASTN1 ZFHX3 ADGRL3 SMAD9	1.21e-06	189	127	7	07208d32afca6f93207a2ac35b647b31a9f71b7c
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	PDE4D MYO1E DTNA LAMA3 RYR3 ROCK1 ADGRL3	1.21e-06	189	127	7	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE4D ADAMTS1 DTNA IRS1 ADAMDEC1 LOXL2 ADGRL3	1.39e-06	193	127	7	146e8c148478ab61b1c1dbaf1ee98a8cd4a0ff8a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 PDE4D MYO1E LGALS3 FAM83B DOCK7 AKAP13	1.44e-06	194	127	7	46070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 PDE4D MYO1E LGALS3 FAM83B DOCK7 AKAP13	1.44e-06	194	127	7	abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_venous\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RASGRF2 ADAMTS1 LRRC32 SACS ARHGAP31 ELFN1 LOXL2	1.70e-06	199	127	7	d359f3e1595ba8d8a3dc9eb2e8f2b61f3247c7a1
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	TANC2 ITSN1 TRIP12 IQGAP1 AKAP9 RLIM ROCK1	1.70e-06	199	127	7	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	mild-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BDP1 PDE4D RASGRF2 COLQ RASGRP1 HELZ PBXIP1	1.70e-06	199	127	7	cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell	LPS_IL1RA\|World / Treatment groups by lineage, cell group, cell type	COL12A1 MYO1E ACSL4 ARHGAP31 TLN1 NOCT ADGRL3	1.76e-06	200	127	7	a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCell	5'-Airway_Nasal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 KIF21A MUC16 AKR1A1 LGALS3 CAPN13 TJP3	1.76e-06	200	127	7	f6e967738b4f7b173d6e9977e305f77380dd6c8a
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 KIF21A MUC16 CPD AKR1A1 LGALS3 CAPN13	1.76e-06	200	127	7	b68d212159b9d04866ba02ff55c35be247805eec
ToppCell	5'-Airway_Nasal-Epithelial\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 KIF21A MUC16 AKR1A1 LGALS3 CAPN13 TJP3	1.76e-06	200	127	7	358d71329921451c7f5a56f1db0f9989af2299dc
ToppCell	LPS-IL1RA-Endothelial-Mes-Like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CPZ THAP9 RYR3 SACS KCNH1 CFAP44	3.79e-06	145	127	6	90ca38c02325c5c637c32efdef634b54cc3cd105
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPO MUC16 ZC2HC1C CPE CPZ SMPD3	1.04e-05	173	127	6	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPO MUC16 ZC2HC1C CPE CPZ SMPD3	1.04e-05	173	127	6	3725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC32 AOX1 CPE SUSD5 LOXL2 ZFHX3	1.08e-05	174	127	6	778e0317c0c63fa4efd74114feb760975b819d92
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRLF1 LRRC45 TTC36 NR6A1 SRPRB SNX14	1.19e-05	177	127	6	c6812679aa6522d03bd29144e71c5fae6a92325e
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRLF1 LRRC45 TTC36 NR6A1 SRPRB SNX14	1.19e-05	177	127	6	ff97398d2adb83063b7c53a264bfae86ea7ea304
ToppCell	droplet-Limb_Muscle-Pre-Sort\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS1 MYO1H LRRC32 OAZ1 CPE SUSD5	1.31e-05	180	127	6	af2bafcd1b2082629de3ea336711add01565c4c4
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS1 MYO1H LRRC32 OAZ1 CPE SUSD5	1.31e-05	180	127	6	f29a995cf6e1a1836ed68b73258d9370bf3d4434
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SOX6 PDE4D MYO1E SPTBN2 FAM83B RASGRP1	1.35e-05	181	127	6	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	ASK454-Epithelial\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	COL12A1 CEACAM5 DTNA LAMA3 CAPN13 RP1	1.39e-05	182	127	6	ab15316cff989b61ff397a866d7ca8b49c13e981
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 LAMA3 IQGAP1 FAM83B ACSL4 RP1	1.39e-05	182	127	6	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	MYO1E DTNA LAMA3 SUSD5 ROCK1 ADGRL3	1.43e-05	183	127	6	818fd886e0188091310825f9145fa53328f2c979
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE4D ADAMTS1 DTNA ADAMDEC1 LOXL2 ADGRL3	1.43e-05	183	127	6	af8d86f15a549064530d94bd47081daf59d58ecd
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	PDE4D MYO1E DTNA LAMA3 CPE SUSD5	1.43e-05	183	127	6	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 COL12A1 LRRC4C RYR3 NAV3 ADGRL3	1.48e-05	184	127	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 COL12A1 LRRC4C RYR3 NAV3 ADGRL3	1.48e-05	184	127	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 COL12A1 LRRC4C RYR3 NAV3 ADGRL3	1.48e-05	184	127	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	SOX6 DOK6 RASGRF2 HECTD4 R3HDM2 NR6A1	1.57e-05	186	127	6	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX6 TANC2 RASGRF2 LRRC32 LAMA3 CPE	1.57e-05	186	127	6	1e67bfb248366d7395efdd2d5e70a97bdb2e68af
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LAMA3 MUC16 TLN1 ASTN1 ROCK1 ZFHX3	1.57e-05	186	127	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	SOX6 DOK6 RASGRF2 HECTD4 R3HDM2 NR6A1	1.57e-05	186	127	6	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 MYO1E LAMA3 LGALS3 FAM83B RP1	1.62e-05	187	127	6	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	PND03\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RUNX1 LGALS3 IQGAP1 TLN1 AKAP13 CFAP44	1.62e-05	187	127	6	b3fcb36d853adfdea7172c5591de06f027e50af3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 MYO1E LAMA3 LGALS3 FAM83B RP1	1.62e-05	187	127	6	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 MYO1E LAMA3 LGALS3 FAM83B RP1	1.62e-05	187	127	6	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	PDE4D MYO1E RASGRF2 ADAMTS1 LRRC32 ARHGAP31	1.62e-05	187	127	6	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	ASK454-Epithelial-Type_1\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	COL12A1 CEACAM5 DTNA LAMA3 CAPN13 RP1	1.67e-05	188	127	6	13f8ce8f24ac7d7ed87f4ae3b8f4096de29383c2
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 KIF21A MUC16 CPD CAPN13 TJP3	1.77e-05	190	127	6	6ea9fa08bd97bedcb21d3654467e7f8dd74c8fd0
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CRLF1 ADAMTS1 DTNA CPE SUSD5 ZFHX3	1.77e-05	190	127	6	73d94fbae92029745989a8712eed8b99fd84c193
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 KIF21A MUC16 RP1 CFAP44 TJP3	1.77e-05	190	127	6	2fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO1E ARHGAP31 LOXL2 NOCT APOL2 ADGRL3	1.83e-05	191	127	6	a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS1 DTNA CPE IRS1 SUSD5 ZFHX3	1.83e-05	191	127	6	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TANC2 ARHGEF5 CC2D1A ZFHX3 PBXIP1 VAV1	1.83e-05	191	127	6	54f07e4de61735051498846afb44b1798bed8144
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS1 DTNA CPE IRS1 SUSD5 ZFHX3	1.88e-05	192	127	6	992d08092edbc68c47b945deb8708379738c239a
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-SVEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO1E RASGRF2 ADAMTS1 LRRC32 LOXL2 NAV3	1.88e-05	192	127	6	c3dda7c48732b0b8bde36de282d64192f5e9b98f
ToppCell	Mesenchymal-matrix_fibroblast_2_cell\|World / Lineage, Cell type, age group and donor	DOK6 COL12A1 AOX1 CPE NAV3 ASTN1	1.88e-05	192	127	6	a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell	ILEUM-inflamed-(8)_Smooth_muscle_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SOX6 TSHZ3 COL12A1 DTNA LOXL2 ADGRL3	1.94e-05	193	127	6	084c88f08ce0ecd6c9f4334caed370eb2154f896
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS1 LRRC32 CPE RYR3 ARHGAP31 RP1	1.94e-05	193	127	6	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 CRLF1 ACTN3 RUNX1 RYR3 NEU2	1.94e-05	193	127	6	1aa3ab528605dc7b2fec46e759c9d1ee93d59b11
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO1E LRRC32 ARHGAP31 NOCT APOL2 ADGRL3	2.05e-05	195	127	6	56efeb58df19f357d7d5ce87348d4f196a595421
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL12A1 DTNA LAMA3 NR6A1 CAPN13 RP1	2.05e-05	195	127	6	a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCell	IPF-Endothelial-VE_Peribronchial\|IPF / Disease state, Lineage and Cell class	RASGRF2 ADAMTS1 LRRC32 LOXL2 NAV3 SMAD9	2.05e-05	195	127	6	2c3ad3cb79f11119ac69c413a938d21199145040
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SOX6 PDE4D DNAAF9 NR6A1 RP1 PARD3	2.05e-05	195	127	6	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	COVID-19-kidney-TAL\|kidney / Disease (COVID-19 only), tissue and cell type	TANC2 ADAMTS1 CPD FAM83B ACSL4 RP1	2.11e-05	196	127	6	04f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-skeletal_muscle_satellite_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 TSHZ3 PDE4D CRLF1 RUNX1 NOCT	2.11e-05	196	127	6	97ac47daf5bb07fa5dda3976e1ae402750f959b5
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 PDE4D CRLF1 ACTN3 RUNX1 NOCT	2.17e-05	197	127	6	5bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF21A DNAH2 MUC16 AKAP9 RP1 CFAP44	2.17e-05	197	127	6	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RASGRF2 LRRC32 RYR3 ARHGAP31 NAV3 SMAD9	2.17e-05	197	127	6	cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF21A DNAH2 MUC16 AKAP9 RP1 CFAP44	2.17e-05	197	127	6	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-chondrocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21A CPE LGALS3 SUSD5 PDE4DIP SMPD3	2.17e-05	197	127	6	8786125b669d5d0b15e12df0ade6b319f09f7333
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF21A DNAH2 MUC16 AKAP9 RP1 CFAP44	2.17e-05	197	127	6	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF21A DNAH2 MUC16 AKAP9 RP1 CFAP44	2.17e-05	197	127	6	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RASGRF2 LRRC32 RYR3 ARHGAP31 NAV3 SMAD9	2.17e-05	197	127	6	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	TANC2 PDE4D RASGRF2 DTNA LRRC4C RUNX1	2.17e-05	197	127	6	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CEACAM5 MYO1E LAMA3 LGALS3 SAMD9L TJP3	2.24e-05	198	127	6	efdbac7a3a02bff4ca48841772e0c136556c2b9b
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CEACAM5 MYO1E LAMA3 CC2D1A LGALS3 TJP3	2.24e-05	198	127	6	a631be84e29c277216d89ec6265bd43e87c1dc86
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RASGRF2 LRRC32 RYR3 ARHGAP31 NAV3 SMAD9	2.24e-05	198	127	6	0a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KIF21A CPE LGALS3 SUSD5 PDE4DIP SMPD3	2.24e-05	198	127	6	3575620db5aeaeb0bdcd7a8ff65c43abd3fa13e4
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 KIF21A MUC16 AKAP9 RP1 CFAP44	2.24e-05	198	127	6	d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 KIF21A SPTBN2 MUC16 LGALS3 TJP3	2.30e-05	199	127	6	8bf8d7cd774479f065bbbbcb5a4bd1aa91aa0d85
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TSHZ3 RASGRF2 ADAMTS1 IRS1 LOXL2 PARD3	2.30e-05	199	127	6	a13f4b8a039304e685464cc8879659824cad5a3e
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DTNA IQGAP1 AKAP9 TLN1 AKAP13 LDLRAD4	2.30e-05	199	127	6	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	TANC2 ITSN1 IQGAP1 AKAP9 RLIM ROCK1	2.30e-05	199	127	6	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM5 KIF21A SPTBN2 MUC16 LGALS3 TJP3	2.30e-05	199	127	6	0c060ef64341659f4b1247d0264ac12e53a7e12e
ToppCell	Macroglial-Astrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DTNA ITSN1 CPE RYR3 DOCK7 PARD3	2.37e-05	200	127	6	941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PDE4D KIF21A RASGRP1 SAMD9L AKAP9 CEP78	2.37e-05	200	127	6	109f673a4967ffa52270a0b4f818b3461288db44
ToppCell	medial-Endothelial-Vein-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADAMTS1 LRRC32 CPE LRRC4C OTC SMAD9	2.37e-05	200	127	6	3f689029f5bc7db0af50a405f1e252aeec529077
ToppCell	medial-Endothelial-Vein\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADAMTS1 LRRC32 CPE LRRC4C OTC SMAD9	2.37e-05	200	127	6	1163e5f6dfb304c94bf8885629350454f4b6bee8
ToppCell	medial-2-Endothelial-Vein\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADAMTS1 LRRC32 CPE LRRC4C OTC SMAD9	2.37e-05	200	127	6	49da4e3ff10262a492c2cf566a7f2e35e418bfda
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CEACAM5 SPTBN2 DNAH2 LGALS3 CAPN13	3.08e-05	126	127	5	cde3b0fbdc324120e45e295eb171ee550653de47
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO TTC36 OTC ASF1B VAV1	6.21e-05	146	127	5	74009a2921359a8352afbaea8c325a3743622543
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO TTC36 OTC ASF1B VAV1	6.21e-05	146	127	5	cb19f2bb6832d11fe69b670df49eac096a378a9d
ToppCell	(02)_Cycling_Basal_(regeneration)-(2)_48hpi\|(02)_Cycling_Basal_(regeneration) / shred by cell type and Timepoint	TTC36 AKR1A1 DDOST PBXIP1 TJP3	6.63e-05	148	127	5	a061a745c09254e063411b7d835d5597a0007e29
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	COL12A1 R3HDM2 RASGRP1 NEU2 BBLN	7.06e-05	150	127	5	9d5bbdca19da60e1a2121ef64ec8e1375a5dbf6d
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	COL12A1 R3HDM2 RASGRP1 NEU2 BBLN	7.75e-05	153	127	5	b37a1ecad389d2848b8ca4d287823e8048207420
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SOX6 MCF2 LRRC4C SUSD5 ADGRL3	8.25e-05	155	127	5	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_A\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SOX6 MYO1E ADAMTS1 ZC2HC1C CEP78	8.76e-05	157	127	5	542944030cd9b3f3559e64f9f6598694d74003c0
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKK1 COL12A1 DTNA RYR3 ASTN1	9.58e-05	160	127	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKK1 COL12A1 DTNA RYR3 ASTN1	9.58e-05	160	127	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	droplet-Marrow-BM-30m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX6 OAZ1 LGALS3 AKAP13 ZFHX3	9.58e-05	160	127	5	822adcf5f9208f305cafffd8ed97f3a061e82b03
ToppCell	RV-13._Vascular_Smooth_Muscle\|RV / Chamber and Cluster_Paper	LAMA3 CPE SUSD5 ZFHX3 ADGRL3	9.86e-05	161	127	5	47b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 LAMA3 RYR3 IQGAP1 FAM83B	1.02e-04	162	127	5	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
Drug	N-Acetyl-L-leucine [1188-21-2]; Down 200; 23uM; MCF7; HT_HG-U133A	ERAP1 LAMA3 CPE THOP1 ZFHX3 ATXN10 NOCT PARD3 APOL2 PRPH	1.71e-07	198	127	10	5683_DN
Drug	Hexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; MCF7; HT_HG-U133A	MYO1E DTNA LAMA3 PDE4DIP PARD3 APOL2 OAZ3 TJP3 PRPH	1.81e-06	199	127	9	6244_DN
Drug	Gabazine [105538-73-6]; Down 200; 10.8uM; PC3; HT_HG-U133A	CEACAM5 DTNA SPTBN2 CUL7 TLN1 APOL2 OAZ3 TJP3	1.46e-05	196	127	8	4236_DN
Drug	aspirin, USP; Up 200; 100uM; MCF7; HT_HG-U133A_EA	CRLF1 DTNA NR6A1 RUNX1 ASTN1 CFAP44 ADGRL3 BBLN	1.52e-05	197	127	8	984_UP
Drug	Isocorydine (+) [475-67-2]; Up 200; 11.8uM; PC3; HT_HG-U133A	CRLF1 CC2D1A NR6A1 RUNX1 LOXL2 PBXIP1 LDLRAD4 ADGRL3	1.57e-05	198	127	8	4505_UP
Drug	Procarbazine hydrochloride [366-70-1]; Up 200; 15.6uM; HL60; HT_HG-U133A	PDE4D MYO1E NR6A1 RUNX1 COLQ ADAMDEC1 APOL2 PBXIP1	1.57e-05	198	127	8	2971_UP
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; MCF7; HT_HG-U133A	CC2D1A CPD CPE ZNF350 NOCT APOL2 VAV1 TJP3	1.69e-05	200	127	8	7002_DN
Drug	chlorsulfuron	FLII THOP1 AKAP13 ILVBL	3.33e-05	33	127	4	CID000047491
Drug	Trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A	RADX NR6A1 STX12 ACSL4 PDE4DIP PBXIP1 PRPH	5.38e-05	173	127	7	5594_UP
Drug	bimoclomol	IRS1 RYR3 AKAP13	5.90e-05	14	127	3	CID009576891
Drug	L-Ornithine	OAZ1 OTC OAZ3	5.90e-05	14	127	3	DB00129
Drug	6-methoxyquinoline	MPO CPD	9.23e-05	3	127	2	CID000014860
Drug	phthalazinone	AOX1 ILVBL	9.23e-05	3	127	2	CID000008394
Drug	2-propylpentanoic acid; Up 200; 1000uM; MCF7; HT_HG-U133A_EA	MPO CRLF1 PDE4DIP AKAP13 ZNF350 PBXIP1 PRPH	9.39e-05	189	127	7	989_UP
Drug	17-AAG; Down 200; 1uM; PC3; HT_HG-U133A	SF3A1 CC2D1A THOP1 PDE4DIP NAV3 NOCT CFAP44	9.39e-05	189	127	7	1206_DN
Drug	oxaprozin; Up 200; 300uM; MCF7; HT_HG-U133A_EA	CC2D1A RUNX1 PDE4DIP AKAP13 ZNF350 PBXIP1 PRPH	9.70e-05	190	127	7	863_UP
Drug	mercuric bromide	SOX6 COL12A1 PDE4D RASGRF2 ADAMTS1 ERAP1 DTNA AOX1 CPE IRS1 ACTN3 LGALS3 LACC1 DOCK7 ASTN1 TRMT1L NOCT	1.02e-04	1076	127	17	ctd:C042720
Drug	Hydrocortisone base [50-23-7]; Up 200; 11uM; PC3; HT_HG-U133A	CRLF1 CC2D1A RUNX1 SUSD5 TLN1 LDLRAD4 SMAD9	1.04e-04	192	127	7	6684_UP
Drug	Sulfamethoxazole [723-46-6]; Down 200; 15.8uM; MCF7; HT_HG-U133A	CUL7 ACSL4 AKAP13 NOCT PARD3 LDLRAD4 BBLN	1.07e-04	193	127	7	4690_DN
Drug	Cefalonium [5575-21-3]; Down 200; 8.8uM; PC3; HT_HG-U133A	DTNA CUL7 RUNX1 TLN1 PDE4DIP ZFHX3 TJP3	1.07e-04	193	127	7	4245_DN
Drug	Novobiocin sodium salt [1476-53-5]; Up 200; 6.4uM; PC3; HT_HG-U133A	ERAP1 DTNA CC2D1A ZC2HC1C PDE4DIP PBXIP1 TJP3	1.07e-04	193	127	7	4569_UP
Drug	0173570-0000 [211245-44-2]; Down 200; 1uM; MCF7; HT_HG-U133A	ERAP1 DTNA CPD ACSL4 THOP1 PBXIP1 PRPH	1.10e-04	194	127	7	4715_DN
Drug	PF-00539745-00 [351321-33-0]; Down 200; 10uM; PC3; HT_HG-U133A	ERAP1 RUNX1 PDE4DIP AKAP13 LDLRAD4 ADGRL3 TJP3	1.14e-04	195	127	7	5979_DN
Drug	troglitazone; Down 200; 10uM; HL60; HT_HG-U133A	FLII DTNA CC2D1A COLQ NDRG3 LDLRAD4 BBLN	1.14e-04	195	127	7	6191_DN
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HG-U133A	DTNA COLQ ACSL4 PDE4DIP AKAP13 CFAP44 LDLRAD4	1.14e-04	195	127	7	1785_UP
Drug	rotenone; Up 200; 1uM; MCF7; HT_HG-U133A	CEACAM5 MYO1E DTNA RUNX1 NEU2 PDE4DIP NOCT	1.14e-04	195	127	7	5943_UP
Drug	Conessine [546-06-5]; Up 200; 11.2uM; PC3; HT_HG-U133A	CEACAM5 MCF2 CC2D1A RUNX1 PDE4DIP HSD3B1 TJP3	1.18e-04	196	127	7	4191_UP
Drug	Epivincamine [6835-99-0]; Down 200; 11.2uM; MCF7; HT_HG-U133A	DTNA AOX1 CPD PDE4DIP AKAP13 NOCT PARD3	1.18e-04	196	127	7	2775_DN
Drug	0173570-0000 [211245-44-2]; Down 200; 1uM; PC3; HT_HG-U133A	MYO1E DTNA RUNX1 NAV3 AKAP13 PARD3 PBXIP1	1.18e-04	196	127	7	7391_DN
Drug	Corynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	DTNA RUNX1 TLN1 ZFHX3 OAZ3 PBXIP1 TJP3	1.18e-04	196	127	7	4227_DN
Drug	Azathymine, 6 [932-53-6]; Down 200; 31.4uM; MCF7; HT_HG-U133A	DTNA AOX1 TLN1 AKAP13 CFAP44 APOL2 PRPH	1.18e-04	196	127	7	2827_DN
Drug	Gly-His-Lys acetate salt; Down 200; 1uM; PC3; HT_HG-U133A	TANC2 DTNA SPTBN2 CPD AKAP9 PBXIP1 LDLRAD4	1.22e-04	197	127	7	6570_DN
Drug	Xylazine [7361-61-7]; Down 200; 18.2uM; PC3; HT_HG-U133A	CUL7 RUNX1 PDE4DIP ASTN1 AKAP13 LDLRAD4 BBLN	1.22e-04	197	127	7	4066_DN
Drug	Tyloxapol [25301-02-4]; Down 200; 4uM; MCF7; HT_HG-U133A	DTNA LAMA3 PDE4DIP ZFHX3 APOL2 VAV1 PRPH	1.22e-04	197	127	7	5672_DN
Drug	Mephenesin [59-47-2]; Down 200; 22uM; PC3; HT_HG-U133A	RUNX1 PDE4DIP AKAP13 ZNF350 NOCT PARD3 APOL2	1.22e-04	197	127	7	7374_DN
Drug	Norethynodrel [68-23-5]; Up 200; 13.4uM; MCF7; HT_HG-U133A	RUNX1 ACSL4 NEU2 KCNH1 PDE4DIP NOCT OAZ3	1.25e-04	198	127	7	7471_UP
Drug	Amyleine hydrochloride [532-59-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	ITSN1 NDRG3 PDE4DIP PARD3 OAZ3 PBXIP1 PRPH	1.25e-04	198	127	7	1491_DN
Drug	Reserpinic acid hydrochloride; Down 200; 9.2uM; PC3; HT_HG-U133A	CEACAM5 SPTBN2 CC2D1A AKAP13 PARD3 OAZ3 TJP3	1.25e-04	198	127	7	6603_DN
Drug	Vitamin K2 [11032-49-8]; Down 200; 9uM; MCF7; HT_HG-U133A	CDKN2AIP AOX1 CUL7 RUNX1 LOXL2 ZNF350 PARD3	1.25e-04	198	127	7	4356_DN
Drug	Nifurtimox [23256-30-6]; Down 200; 14uM; MCF7; HT_HG-U133A	CEACAM5 MYO1E DTNA ITSN1 AOX1 LAMA3 CC2D1A	1.25e-04	198	127	7	7328_DN
Drug	Betaxolol hydrochloride [63659-19-8]; Up 200; 11.6uM; PC3; HT_HG-U133A	PDE4D DTNA CC2D1A OTC HSD3B1 ADGRL3 PRPH	1.25e-04	198	127	7	4608_UP
Drug	Zomepirac sodium salt [64092-48-4]; Down 200; 12.8uM; PC3; HT_HG-U133A	TANC2 ACSL4 LOXL2 PDE4DIP AKAP13 PBXIP1 BBLN	1.25e-04	198	127	7	4479_DN
Drug	Cephalexin monohydrate [23325-78-2]; Up 200; 11uM; MCF7; HT_HG-U133A	ERAP1 ITSN1 NR6A1 CUL7 RUNX1 NEU2 APOL2	1.25e-04	198	127	7	5615_UP
Drug	Hexamethonium dibromide dihydrate [55-97-0]; Down 200; 10uM; MCF7; HT_HG-U133A	DTNA ITSN1 CPD CPE NDRG3 PDE4DIP AKAP13	1.25e-04	198	127	7	1482_DN
Drug	Hydrastinine hydrochloride [4884-68-8]; Up 200; 16.4uM; PC3; HT_HG-U133A	MPO RUNX1 PDE4DIP AKAP13 OAZ3 LDLRAD4 TJP3	1.25e-04	198	127	7	5075_UP
Drug	Mefenamic acid [61-68-7]; Down 200; 16.6uM; MCF7; HT_HG-U133A	TMPRSS15 CDKN2AIP AKAP9 PDE4DIP CFAP44 TJP3 PRPH	1.29e-04	199	127	7	5534_DN
Drug	Laudanosine (R,S) [1699-51-0]; Down 200; 11.2uM; MCF7; HT_HG-U133A	DTNA ITSN1 AOX1 CPD CUL7 NDRG3 AKAP13	1.29e-04	199	127	7	7030_DN
Drug	Propranolol hydrochloride [318-98-9]; Down 200; 13.6uM; HL60; HT_HG-U133A	TANC2 PDE4D ADAMTS1 CUL7 RUNX1 PDE4DIP APOL2	1.29e-04	199	127	7	3059_DN
Drug	Tyloxapol [25301-02-4]; Down 200; 4uM; HL60; HT_HG-U133A	ADAMTS1 ERAP1 DTNA RUNX1 COLQ LDLRAD4 ADGRL3	1.29e-04	199	127	7	3074_DN
Drug	Glimepiride [93479-97-1]; Down 200; 8.2uM; PC3; HT_HG-U133A	RUNX1 AKAP9 PDE4DIP NAV3 ZFHX3 APOL2 TJP3	1.33e-04	200	127	7	6628_DN
Drug	Tiabendazole [148-79-8]; Up 200; 19.8uM; PC3; HT_HG-U133A	PDE4D CRLF1 ZC2HC1C RUNX1 PDE4DIP LDLRAD4 TJP3	1.33e-04	200	127	7	4579_UP
Drug	Dehydroisoandosterone 3-acetate [853-23-6]; Down 200; 12.2uM; HL60; HT_HG-U133A	MYO1E ADAMTS1 DTNA COLQ ZFHX3 NOCT LDLRAD4	1.33e-04	200	127	7	3097_DN
Drug	dithiotreitol	MPO ANKK1 DTNA SPTBN2 LAMA3 MAGEE2 RYR3 OTC NEU2 THOP1	1.52e-04	430	127	10	CID000019001
Disease	Prostatic Neoplasms	MPO PDE4D ARHGEF5 ITSN1 AOX1 IRS1 RUNX1 ACSL4 RLIM AKAP13 ZFHX3 HSD3B1 PARD3 TJP3	3.08e-07	616	123	14	C0033578
Disease	Malignant neoplasm of prostate	MPO PDE4D ARHGEF5 ITSN1 AOX1 IRS1 RUNX1 ACSL4 RLIM AKAP13 ZFHX3 HSD3B1 PARD3 TJP3	3.08e-07	616	123	14	C0376358
Disease	esophageal carcinoma	PDE4D HECTD4 RUNX1	2.64e-04	30	123	3	EFO_0002916
Disease	Liver Cirrhosis, Experimental	COL12A1 ERAP1 TTC36 R3HDM2 LGALS3 IQGAP1 OTC LOXL2 DOCK7 NOCT VAV1	4.05e-04	774	123	11	C0023893
Disease	Abnormality of refraction	TSHZ3 CPZ LRRC4C RUNX1 BIRC6 SUSD5 AKAP13 ZFHX3 PARD3 ADGRL3	5.31e-04	673	123	10	HP_0000539
Disease	heart failure	MYO1E HECTD4 AKR1A1 ZFHX3 HEATR5B	1.09e-03	185	123	5	EFO_0003144
Disease	hair colour measurement	SOX6 FLII PDE4D ADAMTS1 NR6A1 KCNH1 AKAP13 PARD3 SMAD9	1.12e-03	615	123	9	EFO_0007822
Disease	chronotype measurement	SOX6 TANC2 TSHZ3 DTNA KIF21A R3HDM2 BIRC6 FAM83B NAV3 NOCT ADGRL3	1.18e-03	882	123	11	EFO_0008328
Disease	Orofacial cleft	TANC2 DCAF4L2 NR6A1	1.27e-03	51	123	3	HP_0000202
Disease	esophageal squamous cell carcinoma	PDE4D RUNX1	1.30e-03	13	123	2	EFO_0005922
Disease	Liver carcinoma	MPO DCAF4L2 ADAMTS1 TTC36 IRS1 IQGAP1 ACSL4 ASF1B	1.32e-03	507	123	8	C2239176
Disease	aspartate aminotransferase measurement	SOX6 BDP1 CDKN2AIP HECTD4 DNAH2 R3HDM2 PANX1 BIRC6 AKAP13 APOL2 TJP3	1.44e-03	904	123	11	EFO_0004736
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	FLII TSHZ3 RASGRF2 LRRC4C BIRC6 ELFN1 HELZ ZFHX3 NOCT ADGRL3	1.96e-03	801	123	10	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	hair color	SOX6 HECTD4 KCNH1 CDK5RAP1 ATXN10 PARD3	1.98e-03	311	123	6	EFO_0003924
Disease	endometriosis (biomarker_via_orthology)	RUNX1 VAV1	1.99e-03	16	123	2	DOID:289 (biomarker_via_orthology)
Disease	sphingomyelin 14:0 measurement	PDE4D ZFHX3	2.25e-03	17	123	2	EFO_0010390
Disease	Colorectal Carcinoma	MPO RASGRF2 SF3A1 SPTBN2 CPE ACSL4 AKAP9 SACS SMAD9	2.76e-03	702	123	9	C0009402
Disease	type 1 diabetes mellitus (biomarker_via_orthology)	LGALS3 VAV1	2.81e-03	19	123	2	DOID:9744 (biomarker_via_orthology)
Disease	coronary artery calcification	BDP1 MYO1E DTNA SF3A1 DOCK7 NAV3 ASTN1	2.86e-03	450	123	7	EFO_0004723
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	DNAH2 ZFHX3	3.12e-03	20	123	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	childhood trauma measurement, alcohol consumption measurement	TANC2 PCDHGC5 LRRC4C	3.29e-03	71	123	3	EFO_0007878, EFO_0007979
Disease	polycystic ovary syndrome (biomarker_via_orthology)	HSD17B7 HSD3B1	3.44e-03	21	123	2	DOID:11612 (biomarker_via_orthology)
Disease	myocardial infarction	DOK6 CDKN2AIP HECTD4 ELFN1 ADGRL3 SMAD9	3.55e-03	350	123	6	EFO_0000612
Disease	osteoporosis	SOX6 DOK6 LRRC4C	3.55e-03	73	123	3	EFO_0003882

Protein segments in the cluster

Peptide	Gene	Start	Entry
VNRRVNNFGSGLTAL	ACSL4	131	O60488
QRQQVEAAFQSRGSR	BDP1	2436	A6H8Y1
SVSININRDGFGLNQ	AKAP9	3791	Q99996
RARAQARNLDQSGTN	APOL2	176	Q9BQE5
NRIQQLNSGTFAGLA	ELFN1	166	P0C7U0
ANDANSAARARRLAQ	BIRC6	4566	Q9NR09
RFLSASINEALNNNG	HSD3B1	196	P14060
GSGRQLQLSVFQDLN	C2orf48	56	Q96LS8
EDALGRTSNQLRSFQ	ARHGEF37	461	A1IGU5
LQFLGNIASRNEDSQ	ATXN10	136	Q9UBB4
RLFLRQNTQGAQAEF	ARHGEF5	1466	Q12774
NNFENVARLLVSRQA	ANKK1	471	Q8NFD2
NGNRTLTLFNVTRND	CEACAM5	551	P06731
QSFDADGNLCRSNQL	RASGRP1	71	O95267
SAGNQQALNFTRFLD	AKAP13	106	Q12802
SASLNREGLLNNARD	ADGRL3	1176	Q9HAR2
FLLQNGADVNQRDSR	ACAP3	721	Q96P50
RNTVQSSNNKFRRNF	CAPN13	431	Q6MZZ7
NAQLRNINFSLSEAL	CEP78	491	Q5JTW2
SASSNNFARQIQRRF	DET1	411	Q7L5Y6
DSRLNTLQNQQGNAF	CFAP44	1781	Q96MT7
TFRQNNFARGLDQQL	ASTN1	756	O14525
RALITLGNNAAFSVN	ARMC10	116	Q8N2F6
SAFRQAQRQENALAI	AOX1	426	Q06278
VSFNRGARGQNALRQ	IQGAP1	1056	P46940
AAQNASLRLNNSVSR	R3HDM2	941	Q9Y2K5
RNQRGSRNNGSFLAI	ADAMTS1	756	Q9UHI8
SIFNRRANINANLQG	RADX	656	Q6NSI4
RNIEDALNQLFRNSS	MUC16	14351	Q8WXI7
RNGTQLQNFTLDRSS	MUC16	14416	Q8WXI7
NLQLFLNSYNGRRDL	NDRG3	221	Q9UGV2
LNTQNAIAFRRDQRS	COLQ	331	Q9Y215
FQNDRNDRGALLRAF	OAZ3	181	Q9UMX2
NIDFSLQNQLRLAGA	FLII	391	Q13045
NNLFGNTRNLLTTDF	MAGEE2	216	Q8TD90
ENNGLANSIRDSLNE	LAMA3	2016	Q16787
NANRIALDFQRGNDV	LGALS3	141	P17931
FNGTTNNNGLVRFRI	TMPRSS15	681	P98073
LLRFSSQIHNNGQSD	LOXL2	596	Q9Y4K0
ADAESGTRNRQLQQL	CDKN2AIP	61	Q9NXV6
SDRFNRILANTNTDQ	DCAF4L2	71	Q8NA75
LADRNSNVRRSFNGT	FAM83B	456	Q5T0W9
VSSNDRASLINNAFQ	ERAP1	631	Q9NZ08
RLNISDVNDNAPRFN	PCDHGC5	441	Q9Y5F6
RILLNNAAFRNGHNF	OTC	6	P00480
QNAALRGELSQARGQ	PRPH	121	P41219
GLLAVNQRFQDNGRA	MPO	361	P05164
VRNNFAALTNLQDRA	PDE4D	236	Q08499
ASNLNRRSQSFNSID	NAV3	266	Q8IVL0
SSRLNGALRQEQNFA	CUL7	1011	Q14999
IVRRSNDTNFVLGNA	KCNH1	21	O95259
QENLRRLANAAGFNV	LACC1	226	Q8IV20
AANGALQRLDLRNNQ	LRRC45	141	Q96CN5
NGLANLNTLELFDNR	LRRC4C	121	Q9HCJ2
NNGEKNARQRLLDSS	PANX1	411	Q96RD7
TNLAEQLQNNRFGSD	HECTD4	381	Q9Y4D8
AFTRVNLSPNRNQSA	IRS1	1071	P35568
DSLARVNNLFNTQAR	SMPD3	136	Q9NY59
RGNSQRDHNLSANLF	OAZ1	81	P54368
GLQARNNARVIFSGS	DDOST	246	P39656
GSVALETLRQQQARF	HELZ	1501	P42694
FANLASLQRLNLQGN	LRRC32	406	Q14392
RARVQAQSTNDGLDF	NEU2	241	Q9Y3R4
DFSQLQRNILASNPR	ASF1B	131	Q9NVP2
AAQNSRLSLQRTQAG	HEATR5B	541	Q9P2D3
NRGALQAVDQLSLFR	ILVBL	156	A1L0T0
SGRQNAQNLDLNRNF	CPZ	311	Q66K79
LNFANRQGSARNITV	DOCK7	571	Q96N67
ALNFIRQQNFRTQAG	COL12A1	1281	Q99715
LLAAGVQREQNERFN	DOK6	126	Q6PKX4
RFCSRQLNGAALIQQ	ITSN1	1331	Q15811
TSTRAQQQLAFLEGR	CC2D1A	486	Q6P1N0
FVGRSNAQGIDLNRN	CPE	176	P16870
SVIGRNNSNNFDLNR	CPD	621	O75976
SALEAQQNRSARQSA	DNAAF9	801	Q5TEA3
DLLSVALNRNFNQQG	HSD17B7	201	P56937
ESNRQTRLEFQQQLG	BBLN	61	Q9BUW7
RSIFENQQAGFRNLA	MCF2	411	P10911
VQEAFAQSSRRNLRN	DTNA	601	Q9Y4J8
ANLNGSRQRSGDNLV	CRLF1	101	O75462
QDGSRQAQSNLTFLS	DNAH2	326	Q9P225
LRGLSQNLFSNSDHQ	SASS6	611	Q6UVJ0
LRQARANFSAARNDL	SACS	4451	Q9NZJ4
FRSAQGCDLLQNLQN	NOCT	296	Q9UK39
NQFQRDNARSSLSAS	PARD3	211	Q8TEW0
SRQQAINSRYQDGQL	RP1	676	P56715
DENNNLLNNRFQGSR	RP1	2066	P56715
NFLNQDIRGLTSASQ	NR6A1	396	Q15406
NQVARFNDLRFVGRS	RUNX1	126	Q01196
AVYRVNNNRGNSLTL	SRPRB	101	Q9Y5M8
QNGSQGLQLEAARLS	SUSD5	46	O60279
SSLNSDNLDAGNRQA	TRMT1L	106	Q7Z2T5
RSLELFFATSQNNRG	RASGRF2	696	O14827
NQNLSLFVREGASSR	SAMD9L	336	Q8IVG5
DNLYRQLSRDSRQGQ	TANC2	1961	Q9HCD6
AQFVARNGRQFLTQL	SF3A1	171	Q15459
NNRNRFCLGLLSNVN	SMAD9	306	O15198
QRTLAAAAAAQQGFL	SOX6	276	P35712
AQLLSGISFNNRRVG	ADAMDEC1	306	O15204
VNERLRRQFAAQANA	ACTN3	641	Q08043
VQALGLSNFNSRQID	AKR1A1	156	P14550
VTLLGQNVNSFRDNS	CDK5RAP1	311	Q96SZ6
TQFRSLLQGQDSASQ	nan	21	Q96MF0
NEDGRFTAQLNRASQ	TRAV12-1	76	A0A0B4J245
AQLRGALQQGEAFQR	PBXIP1	311	Q96AQ6
LSENQRLVSQDNFGL	SPTBN2	441	O15020
LNRGSLSLDDFRNTQ	SNX14	481	Q9Y5W7
NSNIFSFLQRRVENG	THAP9	256	Q9H5L6
RNELNVFNRLTVSQG	KIF21A	1281	Q7Z4S6
ALIRGNRNNCAQFSN	RYR3	526	Q15413
QEAQSRLNEAAAGLN	TLN1	1236	Q9Y490
SAALNNFQAVQRRVS	STX12	111	Q86Y82
RFSLEINVNRNNGSQ	RLIM	136	Q9NVW2
CSQRANNGRFTLRDL	VAV1	311	P15498
TFRALNESGNAFRQS	ZNF840P	121	A6NDX5
TSNIQRLRQEFGSDQ	ARHGAP31	61	Q2M1Z3
ATDFRRQVLSLNLNG	USP38	466	Q8NB14
QELNARARALQAASA	USP38	991	Q8NB14
LQAQFAASLRQTSEG	TSHZ3	906	Q63HK5
SNRRYLSSANPNDNR	ROCK1	401	Q13464
REFSSRNFGVRNQGN	ZC2HC1C	171	Q53FD0
RGFAQDRNLVNAVNV	ZNF350	501	Q9GZX5
NGVSSQNLSLNDTRR	TJP3	241	O95049
SAYNNRAQARRLQGD	TTC36	86	A6NLP5
FSQFAQGRRQRQQQG	UBAC2	256	Q8NBM4
ALRASNNDLNVATNF	UBAC2	326	Q8NBM4
ESRQANTGLFNLRQI	THOP1	541	P52888
AAQFLNSGNVRHRLQ	TRIP12	1331	Q14669
DNFSNLHRRNISNTG	ZNF195	226	O14628
FDGANRRNRLSFNSE	ZFHX3	561	Q15911
QRSNAHRGSRLQFQQ	LDLRAD4	271	O15165
FGNAKTVRNNNSSRF	MYO1E	156	Q12965
LEAFGNARTLRNDNS	MYO1H	146	Q8N1T3
NARTLRNDNSSRFGK	MYO1H	151	Q8N1T3
LGQSFREQLAQGSQL	PDE4DIP	1526	Q5VU43