Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transketolase or transaldolase activity	TKT ILVBL	2.64e-05	5	33	2	GO:0016744
GeneOntologyMolecularFunction	thiamine pyrophosphate binding	TKT ILVBL	7.37e-05	8	33	2	GO:0030976
GeneOntologyMolecularFunction	quaternary ammonium group binding	TKT ILVBL	2.62e-03	46	33	2	GO:0050997
Domain	Znf_BED	ZNF181 ZBED5	1.74e-04	12	31	2	IPR003656
Domain	THDP-binding	TKT ILVBL	2.06e-04	13	31	2	IPR029061
Domain	-	TKT ILVBL	2.06e-04	13	31	2	3.40.50.970
Domain	ADAM_spacer1	ADAMTS3 ADAMTS9	6.60e-04	23	31	2	IPR010294
Domain	ADAM_spacer1	ADAMTS3 ADAMTS9	6.60e-04	23	31	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS3 ADAMTS9	7.19e-04	24	31	2	IPR013273
Domain	Peptidase_M12B_N	ADAMTS3 ADAMTS9	1.90e-03	39	31	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS3 ADAMTS9	1.90e-03	39	31	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS3 ADAMTS9	2.00e-03	40	31	2	PS00427
Domain	ADAM_MEPRO	ADAMTS3 ADAMTS9	2.00e-03	40	31	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS3 ADAMTS9	2.00e-03	40	31	2	PS50214
Domain	Reprolysin	ADAMTS3 ADAMTS9	2.00e-03	40	31	2	PF01421
Domain	Peptidase_M12B	ADAMTS3 ADAMTS9	2.00e-03	40	31	2	IPR001590
Domain	Disintegrin_dom	ADAMTS3 ADAMTS9	2.10e-03	41	31	2	IPR001762
Domain	-	ZBTB40 ZNF573 ZBTB42 ZNF181 ZFP62	4.85e-03	679	31	5	3.30.160.60
Domain	TSP_1	ADAMTS3 ADAMTS9	4.89e-03	63	31	2	PF00090
Domain	TSP1	ADAMTS3 ADAMTS9	5.20e-03	65	31	2	SM00209
Domain	TSP1_rpt	ADAMTS3 ADAMTS9	5.20e-03	65	31	2	IPR000884
Domain	TSP1	ADAMTS3 ADAMTS9	5.20e-03	65	31	2	PS50092
Domain	Znf_C2H2/integrase_DNA-bd	ZBTB40 ZNF573 ZBTB42 ZNF181 ZFP62	5.32e-03	694	31	5	IPR013087
Domain	MetalloPept_cat_dom	ADAMTS3 ADAMTS9	7.96e-03	81	31	2	IPR024079
Domain	-	ADAMTS3 ADAMTS9	7.96e-03	81	31	2	3.40.390.10
Domain	ZINC_FINGER_C2H2_2	ZBTB40 ZNF573 ZBTB42 ZNF181 ZFP62	8.42e-03	775	31	5	PS50157
Domain	ZINC_FINGER_C2H2_1	ZBTB40 ZNF573 ZBTB42 ZNF181 ZFP62	8.51e-03	777	31	5	PS00028
Domain	Znf_C2H2-like	ZBTB40 ZNF573 ZBTB42 ZNF181 ZFP62	9.39e-03	796	31	5	IPR015880
Domain	Znf_C2H2	ZBTB40 ZNF573 ZBTB42 ZNF181 ZFP62	9.83e-03	805	31	5	IPR007087
Domain	ZnF_C2H2	ZBTB40 ZNF573 ZBTB42 ZNF181 ZFP62	9.98e-03	808	31	5	SM00355
Domain	ZINC_PROTEASE	ADAMTS3 ADAMTS9	1.15e-02	98	31	2	PS00142
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ZBTB40 DENND4A VWF ADAMTS9 TKT ZNF181	6.60e-06	497	33	6	23414517
Pubmed	RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs.	CSTF3 RBBP6	1.31e-05	6	33	2	25319826
Pubmed	PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.	VWF ADAMTS3 ADAMTS9	2.44e-05	59	33	3	38374152
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS3 ADAMTS9	3.91e-05	10	33	2	11167130
Pubmed	Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.	ADAMTS3 ADAMTS9	4.78e-05	11	33	2	33909046
Pubmed	ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.	ADAMTS3 ADAMTS9	1.04e-04	16	33	2	30579834
Pubmed	Genome-wide association study link novel loci to endometriosis.	ZBTB40 CSMD1	1.48e-04	19	33	2	23472165
Pubmed	Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly.	ADAMTS3 ADAMTS9	2.38e-04	24	33	2	29791855
Pubmed	Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.	CPT1A RBBP6 RPS6KA3	3.39e-04	143	33	3	32560809
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	CSTF3 RBBP6 DDX1 PUS7 NSDHL	3.53e-04	653	33	5	33742100
Pubmed	ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2.	CSTF3 DDX1	6.01e-04	38	33	2	30629181
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	VWF RBBP6 TKT DDX1	6.44e-04	419	33	4	28700943
Pubmed	Network organization of the human autophagy system.	CPT1A PIK3C3 TKT ILVBL	7.54e-04	437	33	4	20562859
Pubmed	Genome-wide association study identifies multiple loci influencing human serum metabolite levels.	CPT1A ADAMTS3	8.80e-04	46	33	2	22286219
Pubmed	Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways.	TKT DDX1 NSDHL	9.13e-04	201	33	3	25192599
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	CSTF3 VSIG8 RBBP6 DDX1 PUS7	9.20e-04	807	33	5	22681889
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS3 ADAMTS9	3.09e-04	19	25	2	50
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB40 ZNF573 ZBTB42 ZNF181 ZFP62	2.67e-03	718	25	5	28
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB40 ZBTB42	1.46e-02	134	25	2	861
Drug	Mebendazole [31431-39-7]; Down 200; 13.6uM; HL60; HT_HG-U133A	DENND4A CPT1A ILVBL PUS7 NSDHL	6.62e-06	185	33	5	2338_DN
Disease	distal arthrogryposis (implicated_via_orthology)	MYH15 ZBTB42	1.11e-04	15	31	2	DOID:0050646 (implicated_via_orthology)
Disease	Antihypertensive use measurement	ARHGAP42 TKT RPS6KA3 NPNT	1.65e-04	265	31	4	EFO_0009927
Disease	airway responsiveness measurement	MYH15 CSMD1	2.91e-04	24	31	2	EFO_0006897
Disease	macrophage colony stimulating factor measurement	ZBTB40 CSMD1	6.95e-04	37	31	2	EFO_0008217
Disease	asthma	ARHGAP42 ADAD1 ADAMTS9 PIK3C3 NPNT	1.03e-03	751	31	5	MONDO_0004979
Disease	physical activity	CSMD1 RBBP6	3.87e-03	88	31	2	EFO_0003940
Disease	reticulocyte measurement	ARHGAP42 ZBTB40 MYH15 DENND4A VWF	4.50e-03	1053	31	5	EFO_0010700

Protein segments in the cluster

Peptide	Gene	Start	Entry
SFEYGMSILYHCKKG	CSMD1	2816	Q96PZ7
MDSYAKSLLHGRCYD	CPT1A	436	P50416
LAHYKDMGKFCLTYE	CPT1A	576	P50416
EAGTYHAAKCMSASY	ADAD1	531	Q96M93
KYDSELMCYAHSKGA	CTBS	86	Q01459
YSKIPRHCMSEDSKY	DENND4A	1701	Q7Z401
TRKGQSMYHYSKLSC	PATE2	66	Q6UY27
GSYICKCHKGFDLMY	NPNT	191	Q6UXI9
HEKKAYSFCGTVEYM	RPS6KA3	221	P51812
KGLMKGKHYYEVSCH	DDX1	126	Q92499
ALMEYYCSKDKSVAF	CSTF3	416	Q12996
MSCVHYKFSSKLNYD	RBBP6	1	Q7Z6E9
EYAMHLSACAYVKDT	GPRC6A	356	Q5T6X5
HLYCQSKETGDVAYM	ADAMTS3	646	O15072
VYCMAKDGSHLESDY	ADAMTS9	1466	Q9P2N4
VACGLAYTDYHKAAM	ILVBL	566	A1L0T0
PNHKDYYNCSAMVSK	CUL9	2271	Q8IWT3
VYTDSLFYMDHKSAK	FPGT	281	O14772
KHYCTYDKGSKTFTM	ARHGAP42	286	A6NI28
DEKYGCYKLTGAIMH	MYH15	356	Q9Y2K3
MGEAEKFHYIYSCDL	PIK3C3	1	Q8NEB9
SYCHFVLYKENKDTM	PUS7	256	Q96PZ0
HYYSCERAKKAMGYQ	NSDHL	336	Q15738
HGDYSNIKAAYEAMK	SPATA13	401	Q96N96
HMTYGNDVVLKCYAS	VSIG8	156	P0DPA2
ECGKAFKMYGYLTQH	ZNF573	586	Q86YE8
DIHYCQGKCASKAMY	VWF	2746	P04275
AACGMAYTGKYFDKA	TKT	131	P29401
AASYLHMYDIVKVCK	ZBTB42	101	B2RXF5
MHLCETGFSYYAATK	ZBED5	641	Q49AG3
ECGKAYMSYSSLINH	ZFP62	201	Q8NB50
LGESEMYYCSKCKTH	USP6	1046	P35125
EKPLDYMNHYTCEKS	ZNF181	551	Q2M3W8
KHSEGKMYACQYCDA	ZBTB40	886	Q9NUA8