Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	5.49e-10	431	40	11	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	PLXNA3 OR2D2 OR5J2 ADGRD2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 IL23R OR10G7 OR10G4 PKD1 OR4E1	2.16e-08	1353	40	15	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2D2 OR5J2 ADGRD2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	9.34e-08	884	40	12	GO:0004930
GeneOntologyMolecularFunction	odorant binding	OR5J2 OR5D14 OR4E1	2.09e-03	127	40	3	GO:0005549
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	4.01e-10	432	40	11	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	8.72e-10	465	40	11	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	1.36e-09	485	40	11	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	3.04e-09	524	40	11	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	4.76e-09	547	40	11	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 PKD1 OR4E1	7.02e-09	722	40	12	GO:0051606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	9.04e-09	582	40	11	GO:0050906
GeneOntologyBiologicalProcess	sensory perception	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 BBS7 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	5.27e-07	1072	40	12	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2D2 OR5J2 ADGRD2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	8.25e-06	1395	40	12	GO:0007186
GeneOntologyBiologicalProcess	peptidyl-lysine trimethylation	FAM86B1 FAM86B2	1.99e-04	11	40	2	GO:0018023
GeneOntologyBiologicalProcess	immunological memory formation process	ST3GAL1 IL23R	3.29e-04	14	40	2	GO:0090715
GeneOntologyCellularComponent	Golgi lumen	GPC1 MUC16 MUC5B MUC3A	5.00e-05	109	39	4	GO:0005796
Domain	Olfact_rcpt	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4	5.60e-09	393	39	10	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4	8.18e-07	670	39	10	IPR017452
Domain	7tm_1	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4	8.99e-07	677	39	10	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4	1.00e-06	685	39	10	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4	1.08e-06	691	39	10	PS50262
Domain	GPCR_Rhodpsn	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4	1.10e-06	692	39	10	IPR000276
Domain	FAM86	FAM86B1 FAM86B2	2.54e-05	4	39	2	PF14904
Domain	FAM86	FAM86B1 FAM86B2	2.54e-05	4	39	2	IPR029426
Domain	Methyltransf_16	FAM86B1 FAM86B2	2.31e-04	11	39	2	IPR019410
Domain	Methyltransf_16	FAM86B1 FAM86B2	2.31e-04	11	39	2	PF10294
Domain	SEA	MUC16 MUC3A	3.81e-04	14	39	2	SM00200
Domain	-	PLXNA3 WDR12 DYNC2I2 BBS7 COPB2	6.12e-04	333	39	5	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	PLXNA3 WDR12 DYNC2I2 BBS7 COPB2	6.29e-04	335	39	5	IPR015943
Domain	SEA	MUC16 MUC3A	1.05e-03	23	39	2	PS50024
Domain	SEA_dom	MUC16 MUC3A	1.05e-03	23	39	2	IPR000082
Domain	GPS	ADGRD2 PKD1	2.29e-03	34	39	2	SM00303
Domain	GPS	ADGRD2 PKD1	2.42e-03	35	39	2	PF01825
Domain	GPS	ADGRD2 PKD1	2.56e-03	36	39	2	PS50221
Domain	GPS	ADGRD2 PKD1	2.70e-03	37	39	2	IPR000203
Domain	WD40_repeat_dom	WDR12 DYNC2I2 BBS7 COPB2	3.33e-03	297	39	4	IPR017986
Domain	G-protein_beta_WD-40_rep	WDR12 COPB2	1.36e-02	85	39	2	IPR020472
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	1.43e-09	417	33	11	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	GPC1 OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	9.52e-09	636	33	12	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4	1.20e-08	389	33	10	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR10G9 OR10G8 OR2L13 OR5D14 OR10G7 OR10G4	1.20e-08	70	33	6	MM14984
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC16 ST3GAL1 MUC5B MUC3A	2.14e-07	23	33	4	M556
Pathway	REACTOME_SENSORY_PERCEPTION	GPC1 OR10G9 OR10G8 OR2L13 OR5D14 OR10G7 OR10G4	2.30e-07	190	33	7	MM15687
Pathway	REACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC	MUC16 MUC5B MUC3A	6.41e-06	16	33	3	M27410
Pathway	REACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS	MUC16 MUC5B MUC3A	7.77e-06	17	33	3	M27412
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	MUC16 ST3GAL1 MUC5B MUC3A	1.26e-05	62	33	4	M546
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC16 ST3GAL1 MUC5B	1.51e-05	21	33	3	MM15706
Pathway	REACTOME_DECTIN_2_FAMILY	MUC16 MUC5B MUC3A	2.93e-05	26	33	3	M27483
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	MUC16 ST3GAL1 MUC5B MUC3A	1.25e-04	111	33	4	M27416
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	GPC1 MUC16 MUC5B MUC3A	3.31e-04	143	33	4	M27275
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	MUC16 ST3GAL1 MUC5B	3.65e-04	60	33	3	MM15636
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	MUC16 MUC5B MUC3A	5.28e-04	68	33	3	M27303
Pathway	WP_BARDETBIEDL_SYNDROME	DYNC2I2 BBS7 PKD1	1.12e-03	88	33	3	M45557
Pathway	REACTOME_PROTEIN_METHYLATION	FAM86B1 FAM86B2	1.19e-03	22	33	2	MM15519
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	MUC16 ST3GAL1 MUC5B	2.07e-03	109	33	3	MM15164
Pathway	REACTOME_DISEASES_OF_METABOLISM	GPC1 MUC16 MUC5B MUC3A	2.64e-03	250	33	4	M27554
Pathway	REACTOME_CARGO_TRAFFICKING_TO_THE_PERICILIARY_MEMBRANE	BBS7 PKD1	3.73e-03	39	33	2	MM15209
Pathway	REACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS	MUC16 MUC5B MUC3A	4.21e-03	140	33	3	M27484
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	1.61e-13	340	41	11	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	1.61e-13	340	41	11	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	1.78e-13	343	41	11	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR2L13 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	1.95e-13	346	41	11	14611657
Pubmed	The human olfactory receptor gene family.	OR2D2 OR5J2 OR10G9 OR10G8 OR10P1 OR5D14 OR1Q1 OR10G7 OR10G4 OR4E1	5.56e-10	541	41	10	14983052
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC16 MUC5B MUC3A	1.23e-06	18	41	3	18834073
Pubmed	DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells.	MUC16 MUC5B	4.06e-06	3	41	2	27230679
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR2D2 OR10P1 OR5D14 OR1Q1 OR4E1	5.89e-06	219	41	5	12213199
Pubmed	FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis.	FAM86B1 FAM86B2	1.35e-05	5	41	2	38508183
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC16 MUC5B	2.03e-05	6	41	2	19110483
Pubmed	Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development.	FAT4 VANGL1	1.82e-04	17	41	2	32155439
Pubmed	Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb.	PLXNA3 OR4E1	2.05e-04	18	41	2	20550939
Pubmed	Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.	SLC20A1 DUS4L COPB2	3.69e-04	118	41	3	24453475
Pubmed	Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.	DYNC2I2 VANGL1	4.33e-04	26	41	2	37228654
Pubmed	The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.	FAM86B1 FAM86B2	5.39e-04	29	41	2	12438443
Cytoband	Ensembl 112 genes in cytogenetic band chr11q24	OR10G9 OR10G8 OR10G7 OR10G4	2.61e-05	191	41	4	chr11q24
Cytoband	11q24.1	OR10G9 OR10G4	5.08e-04	37	41	2	11q24.1
Cytoband	11q11	OR5J2 OR5D14	8.20e-04	47	41	2	11q11
Cytoband	9q34.11	ZDHHC12 DYNC2I2	1.04e-03	53	41	2	9q34.11
Cytoband	12q13.2	SUOX OR10P1	1.12e-03	55	41	2	12q13.2
Cytoband	11q24.2	OR10G8 OR10G7	1.47e-03	63	41	2	11q24.2
Cytoband	Ensembl 112 genes in cytogenetic band chr9q33	ADGRD2 OR1Q1	6.81e-03	138	41	2	chr9q33
GeneFamily	Olfactory receptors, family 10	OR10G9 OR10G8 OR10P1 OR10G7 OR10G4	7.38e-08	66	30	5	157
GeneFamily	CD molecules\|Mucins	MUC16 MUC5B MUC3A	5.37e-06	21	30	3	648
GeneFamily	WD repeat domain containing	WDR12 DYNC2I2 COPB2	9.15e-03	262	30	3	362
GeneFamily	Olfactory receptors, family 5	OR5J2 OR5D14	1.48e-02	112	30	2	152
GeneFamily	Olfactory receptors, family 2	OR2D2 OR2L13	1.50e-02	113	30	2	149
Coexpression	NABA_ECM_AFFILIATED	GPC1 PLXNA3 MUC16 MUC5B MUC3A	6.71e-06	170	41	5	M5880
CoexpressionAtlas	Pluripotent Stem Cells-reprogram_NA_vs_Pluripotent Stem Cells-reprogram_OSK-L-l-p53KD-Confounder_removed-fold2.0_adjp0.05	FAM86B1 FAM86B2	6.18e-06	3	31	2	PCBC_ratio_ESC_vs_iPSC_method-OSK-L-l-p53KD_cfr-2X-p05
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FAT4 MUC5B IL23R OR10G4	1.06e-05	149	41	4	a22417286de8606f0cc94f86b70bce17aeefb9c2
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FAT4 MUC5B IL23R OR10G4	1.06e-05	149	41	4	c5eedb54ef2e0f131aa6730612c921bc19479632
Disease	neural tube defect (implicated_via_orthology)	DYNC2I2 VANGL1	4.62e-05	9	34	2	DOID:0080074 (implicated_via_orthology)
Disease	cholangiocarcinoma (is_marker_for)	MUC16 MUC5B MUC3A	5.55e-05	64	34	3	DOID:4947 (is_marker_for)
Disease	Sjogren's syndrome (is_marker_for)	MUC16 IL23R	3.50e-04	24	34	2	DOID:12894 (is_marker_for)
Disease	pancreatic ductal carcinoma (is_marker_for)	MUC5B MUC3A	2.26e-03	61	34	2	DOID:3587 (is_marker_for)
Disease	squamous cell carcinoma	ST3GAL1 SUOX	2.72e-03	67	34	2	EFO_0000707
Disease	autoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis	SUOX IL23R	2.96e-03	70	34	2	EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
Disease	small vessel stroke	WDR12 FAT4	5.49e-03	96	34	2	EFO_1001504

Protein segments in the cluster

Peptide	Gene	Start	Entry
NWGETTTAITGTSEH	VANGL1	71	Q8TAA9
GQTSSLSWHLVDIVS	EPG5	2146	Q9HCE0
VVSTYSGWVTGLTTE	BBS7	306	Q8IWZ6
TGSEDGTVRIWHSST	COPB2	246	P35606
SAHDSGWTVSTDVTI	FAT4	2846	Q6V0I7
TIGISATWTTLAGSH	ANKRD17	1541	O75179
WTSATSGTLGTTHIT	MUC5B	2771	Q9HC84
TVRTAWTSATSGILG	MUC5B	3466	Q9HC84
WTSATSGILGTTHIT	MUC5B	3471	Q9HC84
TAWTSATSGTLGTTH	MUC5B	4026	Q9HC84
STWASHLTSITIFHG	OR5D14	241	Q8NGL3
TWLTHPAETSTTVSG	MUC16	11576	Q8WXI7
GTWLSGSLHSAVQTI	OR10G7	146	Q8NGN6
GTWLSGSLHSAVQTI	OR10G4	146	Q8NGN3
TAIISHGTTGLVTWD	FAM86B2	126	P0C5J1
GTSGVESVIGSVHTW	GPC1	306	P35052
GLHVTSISWNSTGSV	DYNC2I2	161	Q96EX3
STAIISHGTTGLVTW	FAM86B1	91	Q8N7N1
TWSIINGSTAITVSG	PLXNA3	1031	P51805
GLTSWVTTTKTTSHI	MUC3A	2391	Q02505
TLLATSTWLSGSLHS	OR10G8	141	Q8NGN5
STWLSGSLHSAVQAI	OR10G8	146	Q8NGN5
TGSWIGGIVNTLIHT	OR5J2	146	Q8NH18
TGSWTSGILVSVVDT	OR2D2	146	Q9H210
GFTVVTSDVLHSAWI	FCSK	76	Q8N0W3
TLTSDWRTVGSQHGV	DSCAML1	1761	Q8TD84
TWNSGLTVASISTGH	IL23R	331	Q5VWK5
EATGVSWITVHGRTA	DUS4L	176	O95620
STTHCKVGSVVSVGW	SLC20A1	621	Q8WUM9
ATGLTVWLHGLTASV	PKD1	2581	P98161
STWLSGSLHSAVQTI	OR10G9	146	Q8NGN4
VGTSWLTGIITATTH	OR10P1	146	Q8NGE3
WTSVSHFVLLGISTH	OR1Q1	6	Q15612
GSWTLGSINSLAHTV	OR2L13	146	Q8N349
WVVSAITTGTISHTY	ST3GAL1	216	Q11201
ETWSISINLVGSSGH	MRGPRG-AS1	101	Q2M3A8
GLSGVTVIHSWFTSR	ADGRD2	521	Q7Z7M1
ALTTIGWILSSTSTG	CLDN34	16	H7C241
ALWTGGTIHSIALTS	OR4E1	151	P0C645
HTATSVLGNTSGLWS	TMEM131	1786	Q92545
GGTLVTATWVLTAGH	PRSS42P	106	Q7Z5A4
SSHTSPETGIWVTLG	SUOX	91	P51687
GSLVSLSLTSHTGWV	WDR12	331	Q9GZL7
VLVRTGHTVLTWGIT	ZDHHC12	11	Q96GR4
WSVNGTHGTTSICSV	KLHL29	21	Q96CT2