Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	protein localization to cytosolic proteasome complex	ATXN3L ATXN3	7.77e-06	2	58	2	GO:1904327
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	EZR ATXN3L CCP110 PKD2 ATXN3 HOOK2 ODF2 SPAG5 PHLDB2 CCDC40	2.89e-05	720	58	10	GO:0000226
GeneOntologyBiologicalProcess	microtubule-based process	EZR ATXN3L CCP110 BLOC1S5 PKD2 ATXN3 HOOK2 ODF2 DNAH14 SPAG5 PHLDB2 CCDC40	3.11e-05	1058	58	12	GO:0007017
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process	EZR ATXN3L ATXN3 TAF1 PTTG1IP FAF1	4.28e-05	228	58	6	GO:0045732
GeneOntologyBiologicalProcess	DNA damage response	NEK4 POLD1 BRD4 ATXN3 SMC4 PIDD1 GIGYF2 MCM5 TAF1 HUWE1 PTTG1IP	6.34e-05	959	58	11	GO:0006974
GeneOntologyBiologicalProcess	determination of liver left/right asymmetry	PKD2 CCDC40	1.16e-04	6	58	2	GO:0071910
GeneOntologyCellularComponent	basal cortex	PKD2 PHLDB2	1.57e-04	7	58	2	GO:0045180
GeneOntologyCellularComponent	ciliary basal body	NEK4 EZR PKD2 ODF2 SPAG5	2.06e-04	195	58	5	GO:0036064
GeneOntologyCellularComponent	CD95 death-inducing signaling complex	TNFRSF10A FAF1	2.10e-04	8	58	2	GO:0031265
GeneOntologyCellularComponent	death-inducing signaling complex	TNFRSF10A FAF1	4.09e-04	11	58	2	GO:0031264
GeneOntologyCellularComponent	cytoplasmic region	NEK4 BLOC1S5 PKD2 CFAP210 PHLDB2 CCDC40	4.76e-04	360	58	6	GO:0099568
GeneOntologyCellularComponent	cilium	NEK4 EZR CCP110 PKD2 CFAP210 ODF2 DNAH14 SPAG5 CCDC40	7.68e-04	898	58	9	GO:0005929
GeneOntologyCellularComponent	ciliary rootlet	NEK4 SPAG5	8.86e-04	16	58	2	GO:0035253
GeneOntologyCellularComponent	chromosomal region	DHX36 POLD1 SMC4 MCM5 NLRP2 SPAG5	1.08e-03	421	58	6	GO:0098687
GeneOntologyCellularComponent	nuclear inclusion body	ATXN3L ATXN3	1.39e-03	20	58	2	GO:0042405
GeneOntologyCellularComponent	chromosome, telomeric region	DHX36 POLD1 MCM5 NLRP2	1.45e-03	176	58	4	GO:0000781
Domain	Ataxin-3	ATXN3L ATXN3	9.48e-06	2	58	2	IPR033865
Domain	UIM	ATXN3L ATXN3 HUWE1	5.49e-05	24	58	3	PS50330
Domain	JOSEPHIN	ATXN3L ATXN3	5.66e-05	4	58	2	PS50957
Domain	Josephin	ATXN3L ATXN3	5.66e-05	4	58	2	IPR006155
Domain	Josephin	ATXN3L ATXN3	5.66e-05	4	58	2	PF02099
Domain	Josephin	ATXN3L ATXN3	5.66e-05	4	58	2	SM01246
Domain	UIM_dom	ATXN3L ATXN3 HUWE1	6.23e-05	25	58	3	IPR003903
Domain	UIM	ATXN3L ATXN3	1.40e-03	18	58	2	PF02809
Domain	UIM	ATXN3L ATXN3	1.92e-03	21	58	2	SM00726
Domain	Bromodomain_CS	BRD4 TAF1	2.94e-03	26	58	2	IPR018359
Domain	-	PIDD1 TNFRSF10A NLRP2	3.03e-03	93	58	3	1.10.533.10
Domain	DEATH	PIDD1 TNFRSF10A	3.16e-03	27	58	2	SM00005
Domain	DEATH-like_dom	PIDD1 TNFRSF10A NLRP2	3.61e-03	99	58	3	IPR011029
Domain	Death	PIDD1 TNFRSF10A	4.70e-03	33	58	2	PF00531
Domain	BROMODOMAIN_1	BRD4 TAF1	5.89e-03	37	58	2	PS00633
Domain	Death_domain	PIDD1 TNFRSF10A	6.20e-03	38	58	2	IPR000488
Domain	Bromodomain	BRD4 TAF1	6.20e-03	38	58	2	PF00439
Domain	DEATH_DOMAIN	PIDD1 TNFRSF10A	6.20e-03	38	58	2	PS50017
Domain	BROMODOMAIN_2	BRD4 TAF1	7.19e-03	41	58	2	PS50014
Domain	BROMO	BRD4 TAF1	7.54e-03	42	58	2	SM00297
Domain	Bromodomain	BRD4 TAF1	7.54e-03	42	58	2	IPR001487
Domain	-	BRD4 TAF1	7.54e-03	42	58	2	1.20.920.10
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	MON2 NEK4 EZR CCP110 RCOR1 POLD1 PKD2 SMC4 GIGYF2 DCLK1 SPAG5 PHLDB2 CLASRP CCDC40	4.10e-08	1321	60	14	27173435
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	DHX36 PPIG GTF2E1 RCOR1 POLD1 TAF1 CBFB UTP14C	2.40e-07	370	60	8	22922362
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	PPIG CLK4 ROBO1 TAF1 HUWE1 ODF2 MEX3C	2.79e-06	358	60	7	32460013
Pubmed	N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation.	ATXN3L ATXN3	2.93e-06	2	60	2	21653538
Pubmed	The genomic structure and expression of MJD, the Machado-Joseph disease gene.	ATXN3L ATXN3	2.93e-06	2	60	2	11450850
Pubmed	Temperature-dependent, irreversible formation of amyloid fibrils by a soluble human ataxin-3 carrying a moderately expanded polyglutamine stretch (Q36).	ATXN3L ATXN3	2.93e-06	2	60	2	14661975
Pubmed	YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.	ATXN3L ATXN3	2.93e-06	2	60	2	11978767
Pubmed	Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties.	ATXN3L ATXN3	2.93e-06	2	60	2	21060878
Pubmed	Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.	ATXN3L ATXN3	2.93e-06	2	60	2	17488727
Pubmed	Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.	ATXN3L ATXN3	2.93e-06	2	60	2	17764659
Pubmed	The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models.	ATXN3L ATXN3	2.93e-06	2	60	2	28676741
Pubmed	Regional and age-dependent changes in ubiquitination in cellular and mouse models of spinocerebellar ataxia type 3.	ATXN3L ATXN3	2.93e-06	2	60	2	37122622
Pubmed	Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways.	ATXN3L ATXN3	2.93e-06	2	60	2	30231063
Pubmed	Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism.	EZR STK10	2.93e-06	2	60	2	28430576
Pubmed	Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells.	ATXN3L ATXN3	2.93e-06	2	60	2	23955261
Pubmed	Vulnerability of frontal brain neurons for the toxicity of expanded ataxin-3.	ATXN3L ATXN3	2.93e-06	2	60	2	30576445
Pubmed	Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.	ATXN3L ATXN3	2.93e-06	2	60	2	12914917
Pubmed	Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.	ATXN3L ATXN3	2.93e-06	2	60	2	20064935
Pubmed	A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.	ATXN3L ATXN3	2.93e-06	2	60	2	17632007
Pubmed	Mitochondrial Morphology, Function and Homeostasis Are Impaired by Expression of an N-terminal Calpain Cleavage Fragment of Ataxin-3.	ATXN3L ATXN3	2.93e-06	2	60	2	30364204
Pubmed	Basal and stress-induced Hsp70 are modulated by ataxin-3.	ATXN3L ATXN3	2.93e-06	2	60	2	22777893
Pubmed	Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.	ATXN3L ATXN3	2.93e-06	2	60	2	17626202
Pubmed	Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.	ATXN3L ATXN3	2.93e-06	2	60	2	22843411
Pubmed	Disease-associated oligodendrocyte signatures are spatiotemporally dysregulated in spinocerebellar ataxia type 3.	ATXN3L ATXN3	2.93e-06	2	60	2	36875652
Pubmed	PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.	ATXN3L ATXN3	2.93e-06	2	60	2	18668148
Pubmed	Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model.	ATXN3L ATXN3	2.93e-06	2	60	2	34220448
Pubmed	The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease.	ATXN3L ATXN3	2.93e-06	2	60	2	24683430
Pubmed	Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo.	ATXN3L ATXN3	2.93e-06	2	60	2	8640226
Pubmed	A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.	ATXN3L ATXN3	2.93e-06	2	60	2	25301414
Pubmed	Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.	ATXN3L ATXN3	2.93e-06	2	60	2	19666135
Pubmed	Expanded ATXN3 frameshifting events are toxic in Drosophila and mammalian neuron models.	ATXN3L ATXN3	2.93e-06	2	60	2	22337953
Pubmed	Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death.	ATXN3L ATXN3	2.93e-06	2	60	2	20637808
Pubmed	A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes.	ATXN3L ATXN3	2.93e-06	2	60	2	34716557
Pubmed	Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.	ATXN3L ATXN3	2.93e-06	2	60	2	23626768
Pubmed	Polyglutamine-induced neurodegeneration in SCA3 is not mitigated by non-expanded ataxin-3: conclusions from double-transgenic mouse models.	ATXN3L ATXN3	2.93e-06	2	60	2	20079840
Pubmed	Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk.	CLK4 CLASRP	2.93e-06	2	60	2	12169693
Pubmed	A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.	ATXN3L ATXN3	2.93e-06	2	60	2	25320121
Pubmed	The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina.	ATXN3L ATXN3	2.93e-06	2	60	2	33176149
Pubmed	Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture.	ATXN3L ATXN3	2.93e-06	2	60	2	36010688
Pubmed	Study of subcellular localization and proteolysis of ataxin-3.	ATXN3L ATXN3	2.93e-06	2	60	2	18353661
Pubmed	Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology.	ATXN3L ATXN3	2.93e-06	2	60	2	23242710
Pubmed	Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.	ATXN3L ATXN3	2.93e-06	2	60	2	23349684
Pubmed	Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.	ATXN3L ATXN3	2.93e-06	2	60	2	18502140
Pubmed	Ataxin-3 is subject to autolytic cleavage.	ATXN3L ATXN3	2.93e-06	2	60	2	16939621
Pubmed	Impaired Oligodendrocyte Maturation Is an Early Feature in SCA3 Disease Pathogenesis.	ATXN3L ATXN3	2.93e-06	2	60	2	35042771
Pubmed	Neurodegenerative phosphoprotein signaling landscape in models of SCA3.	ATXN3L ATXN3	2.93e-06	2	60	2	33741019
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	EZR DHX36 RCOR1 SMC4 ROBO1 MCM5 HUWE1	5.68e-06	399	60	7	37536630
Pubmed	Mouse ataxin-3 functional knock-out model.	ATXN3L ATXN3	8.77e-06	3	60	2	20945165
Pubmed	Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.	ATXN3L ATXN3	8.77e-06	3	60	2	25143392
Pubmed	Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).	ATXN3L ATXN3	8.77e-06	3	60	2	23100324
Pubmed	Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.	ATXN3L ATXN3	8.77e-06	3	60	2	15664989
Pubmed	Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease.	ATXN3L ATXN3	8.77e-06	3	60	2	26505994
Pubmed	Genetic analysis of SCA 2 and 3 repeat expansions in essential tremor and atypical Parkinsonism.	ATXN3L ATXN3	8.77e-06	3	60	2	17712857
Pubmed	Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes.	ATXN3L ATXN3	8.77e-06	3	60	2	28854700
Pubmed	CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1.	ATXN3L ATXN3	8.77e-06	3	60	2	7874163
Pubmed	ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3.	ATXN3L ATXN3	8.77e-06	3	60	2	29802126
Pubmed	Genomic structure, promoter activity, and developmental expression of the mouse homologue of the Machado-Joseph disease (MJD) gene.	ATXN3L ATXN3	8.77e-06	3	60	2	15233999
Pubmed	Expanding our understanding of polyglutamine diseases through mouse models.	ATXN3L ATXN3	8.77e-06	3	60	2	10595501
Pubmed	Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.	EZR STK10	8.77e-06	3	60	2	23209304
Pubmed	Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains.	ATXN3L ATXN3	8.77e-06	3	60	2	22761419
Pubmed	Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.	ATXN3L ATXN3	8.77e-06	3	60	2	26490332
Pubmed	NLRP2 and FAF1 deficiency blocks early embryogenesis in the mouse.	NLRP2 FAF1	8.77e-06	3	60	2	28630100
Pubmed	Parkinson Disease Overview	ATXN3 GIGYF2 TAF1	1.39e-05	27	60	3	20301402
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CCP110 RCOR1 BRD4 SMC4 MCM5 HUWE1 CLASRP	1.62e-05	469	60	7	27634302
Pubmed	Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype.	ATXN3L ATXN3	1.75e-05	4	60	2	16099943
Pubmed	Mapping structural interactions using in-cell NMR spectroscopy (STINT-NMR).	ATXN3L ATXN3	1.75e-05	4	60	2	16432517
Pubmed	Proteotoxic stress increases nuclear localization of ataxin-3.	ATXN3L ATXN3	1.75e-05	4	60	2	19843543
Pubmed	KPNB1 modulates the Machado-Joseph disease protein ataxin-3 through activation of the mitochondrial protease CLPP.	ATXN3L ATXN3	1.75e-05	4	60	2	35794401
Pubmed	Structural modeling of ataxin-3 reveals distant homology to adaptins.	ATXN3L ATXN3	1.75e-05	4	60	2	12486728
Pubmed	LHX3 interacts with inhibitor of histone acetyltransferase complex subunits LANP and TAF-1β to modulate pituitary gene regulation.	ATXN3 TAF1	1.75e-05	4	60	2	23861948
Pubmed	Ubiquilin-2 differentially regulates polyglutamine disease proteins.	ATXN3L ATXN3	1.75e-05	4	60	2	32681165
Pubmed	Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.	ATXN3L ATXN3	1.75e-05	4	60	2	20943656
Pubmed	An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.	ATXN3L ATXN3	1.75e-05	4	60	2	16525503
Pubmed	Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.	ATXN3L ATXN3	1.75e-05	4	60	2	22081612
Pubmed	LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.	EZR STK10	1.75e-05	4	60	2	19255442
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	MON2 HOOK2 TAF1	2.12e-05	31	60	3	25838543
Pubmed	The protein interaction landscape of the human CMGC kinase group.	EZR CCP110 PPIG GTF2E1 ATAD3B CLK4 HUWE1 CLASRP	2.50e-05	695	60	8	23602568
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	GTF2E1 BRD4 GIGYF2 MCM5 TAF1	2.71e-05	203	60	5	22083510
Pubmed	CK2 and GSK3 phosphorylation on S29 controls wild-type ATXN3 nuclear uptake.	ATXN3L ATXN3	2.92e-05	5	60	2	20347968
Pubmed	Misfolding promotes the ubiquitination of polyglutamine-expanded ataxin-3, the defective gene product in SCA3/MJD.	ATXN3L ATXN3	2.92e-05	5	60	2	15639784
Pubmed	Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1.	NLRP2 FAF1	2.92e-05	5	60	2	17046979
Pubmed	Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP.	ATXN3L ATXN3	2.92e-05	5	60	2	21855799
Pubmed	Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity.	ATXN3L ATXN3	2.92e-05	5	60	2	21118805
Pubmed	Ataxin-3 plays a role in mouse myogenic differentiation through regulation of integrin subunit levels.	ATXN3L ATXN3	2.92e-05	5	60	2	20668528
Pubmed	The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.	ATXN3L ATXN3	2.92e-05	5	60	2	27851749
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	RCOR1 NUDCD3 HUWE1	3.35e-05	36	60	3	35379950
Pubmed	The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development.	CCP110 ODF2	4.37e-05	6	60	2	22851319
Pubmed	Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.	ATXN3L ATXN3	4.37e-05	6	60	2	19661182
Pubmed	Polyglutamine tracts regulate beclin 1-dependent autophagy.	ATXN3L ATXN3	4.37e-05	6	60	2	28445460
Pubmed	Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.	BRD4 NUDCD3 FAF1	4.61e-05	40	60	3	28805822
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	DHX36 PPIG RCOR1 POLD1 SMC4 MCM5 HUWE1 CBFB PHLDB2 MEX3C	5.00e-05	1247	60	10	27684187
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	CCP110 SYNE1 GIGYF2 FLG2 UTP14C	5.34e-05	234	60	5	36243803
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	EZR ATAD3B BLOC1S5 ATXN3 GIGYF2 MCM5 NUDCD3 HUWE1 FAF1	5.34e-05	1005	60	9	19615732
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	STK10 PPIG BRD4 GIGYF2 HUWE1 ODF2 PHLDB2 CLASRP	5.35e-05	774	60	8	15302935
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	PPIG GTF2E1 RCOR1 POLD1 BRD4 SMC4 MCM5 TAF1 CBFB	5.72e-05	1014	60	9	32416067
Pubmed	The ins and outs of a polyglutamine neurodegenerative disease: spinocerebellar ataxia type 1 (SCA1).	ATXN3L ATXN3	6.11e-05	7	60	2	10860780
Pubmed	Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.	GTF2E1 TAF1	6.11e-05	7	60	2	7667268
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	EZR SYNE1 ROBO1 DAAM2 TAF1 HUWE1 ODF2 CBFB DCLK1 FAF1	6.42e-05	1285	60	10	35914814
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	NEK4 STK10 CCP110 BLOC1S5 POLD1 GIGYF2 HOOK2 MEX3C CLASRP	6.84e-05	1038	60	9	26673895
Pubmed	FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO.	GTF2E1 TAF1	8.14e-05	8	60	2	9765293
Interaction	NINL interactions	CCP110 RCOR1 ATAD3B GPBP1 SMC4 GIGYF2 HUWE1 ODF2 SPAG5	5.93e-06	458	58	9	int:NINL
Interaction	HSPA4L interactions	EZR BRD4 ATXN3 MCM5 HUWE1 CBFB FAF1	7.29e-06	250	58	7	int:HSPA4L
Interaction	SPTAN1 interactions	MON2 NEK4 EZR DHX36 RCOR1 BRD4 SMC4 MCM5 TAF1	1.12e-05	496	58	9	int:SPTAN1
Interaction	PGAM5 interactions	NEK4 EZR POLD1 BRD4 ATXN3 MCM5 HUWE1	1.32e-05	274	58	7	int:PGAM5
Interaction	USP7 interactions	CCP110 SYNE1 BRD4 CPLX2 PKD2 ATXN3 GIGYF2 MCM5 TAF1 HUWE1 FLG2 PHLDB2 MEX3C UTP14C	1.56e-05	1313	58	14	int:USP7
Interaction	PCBP1 interactions	NEK4 DHX36 PPIG POLD1 BRD4 ATXN3 GIGYF2 MCM5 HUWE1 MEX3C	1.93e-05	671	58	10	int:PCBP1
Interaction	HAX1 interactions	BRD4 PKD2 ATXN3 PIDD1 TAF1 HUWE1 CBFB DCLK1	1.94e-05	404	58	8	int:HAX1
Interaction	CDK1 interactions	NEK4 CCP110 GTF2E1 POLD1 BRD4 HUWE1 TNFRSF10A FLG2 SPAG5	4.40e-05	590	58	9	int:CDK1
Interaction	PNKP interactions	ATAD3B BRD4 ATXN3 MCM5 MSANTD4	4.63e-05	137	58	5	int:PNKP
Interaction	RNF126 interactions	POLD1 BRD4 ATXN3 HUWE1 FAF1	4.79e-05	138	58	5	int:RNF126
Interaction	ZGRF1 interactions	NEK4 DHX36 RCOR1	4.97e-05	25	58	3	int:ZGRF1
Interaction	AURKB interactions	EZR RCOR1 ATAD3B POLD1 BRD4 GIGYF2 TAF1 HUWE1 SPAG5 UTP14C	5.61e-05	761	58	10	int:AURKB
Interaction	PRPF8 interactions	EZR BRD4 ATXN3 SMC4 GIGYF2 MCM5 NUDCD3 HUWE1 FLG2 MEX3C	6.60e-05	776	58	10	int:PRPF8
Interaction	KLHL1 interactions	NEK4 NUDCD3 FAF1	7.04e-05	28	58	3	int:KLHL1
Interaction	MOB3C interactions	EZR DHX36 RCOR1 SMC4 ROBO1 MCM5 HUWE1	8.06e-05	364	58	7	int:MOB3C
Interaction	ZBTB21 interactions	RCOR1 BRD4 GIGYF2 DCLK1 PHLDB2	9.96e-05	161	58	5	int:ZBTB21
Interaction	GIGYF2 interactions	RCOR1 GIGYF2 HUWE1 DCLK1 PHLDB2 MEX3C	1.07e-04	263	58	6	int:GIGYF2
Interaction	FAM83C interactions	NEK4 APOA1	1.21e-04	6	58	2	int:FAM83C
Interaction	ACTR1A interactions	NEK4 RCOR1 ATXN3 SMC4 NUDCD3 HUWE1	1.34e-04	274	58	6	int:ACTR1A
Interaction	SIPA1L1 interactions	POLD1 GIGYF2 ODF2 DCLK1 PHLDB2	1.43e-04	174	58	5	int:SIPA1L1
Interaction	DDB1 interactions	CCP110 POLD1 BRD4 ATXN3 PIDD1 MCM5 TAF1 HUWE1 DCLK1	1.57e-04	697	58	9	int:DDB1
Interaction	IFITM5 interactions	PKD2 ATXN3	1.69e-04	7	58	2	int:IFITM5
Interaction	TAF13 interactions	POLD1 TAF1 NLRP2	1.78e-04	38	58	3	int:TAF13
Interaction	DVL2 interactions	RCOR1 ATAD3B POLD1 SYNE1 SMC4 MCM5 ODF2 PHLDB2	1.84e-04	557	58	8	int:DVL2
Interaction	SF3B3 interactions	NEK4 CCP110 POLD1 BRD4 ATXN3 MCM5 NUDCD3 HUWE1	1.86e-04	558	58	8	int:SF3B3
Interaction	CAD interactions	NEK4 POLD1 BRD4 ATXN3 GIGYF2 HUWE1 MEX3C	1.90e-04	418	58	7	int:CAD
Interaction	TUBB4B interactions	NEK4 CCP110 BRD4 ATXN3 MCM5 HUWE1 FAF1 SPAG5	1.91e-04	560	58	8	int:TUBB4B
Interaction	EFTUD2 interactions	NEK4 EZR DHX36 GTF2E1 POLD1 BRD4 ATXN3 SMC4 GIGYF2 MCM5 HUWE1 FLG2 SPAG5	1.94e-04	1449	58	13	int:EFTUD2
Interaction	HSP90AA1 interactions	NEK4 BRD4 ATXN3 SMC4 GIGYF2 MCM5 APOA1 NUDCD3 HUWE1 FLG2 NLRP2 FAF1	2.11e-04	1263	58	12	int:HSP90AA1
Interaction	PPP2R2A interactions	POLD1 BRD4 SMC4 GIGYF2 HUWE1 DCLK1	2.23e-04	301	58	6	int:PPP2R2A
Interaction	RBBP4 interactions	NEK4 RCOR1 POLD1 BRD4 ATXN3 SMC4 HUWE1 CLASRP	2.23e-04	573	58	8	int:RBBP4
Interaction	SLC25A5 interactions	NEK4 EZR BRD4 ATXN3 MCM5 HUWE1 FAF1	2.29e-04	431	58	7	int:SLC25A5
Interaction	FOXP3 interactions	DHX36 PPIG GTF2E1 RCOR1 POLD1 TAF1 CBFB	2.32e-04	432	58	7	int:FOXP3
Interaction	TUBB interactions	NEK4 CCP110 POLD1 BRD4 ATXN3 MCM5 NUDCD3 HUWE1 FAF1	2.33e-04	735	58	9	int:TUBB
Interaction	CENPH interactions	BRD4 PKD2 SPAG5 CCDC40	2.47e-04	106	58	4	int:CENPH
Interaction	SRGAP2 interactions	EZR GIGYF2 ROBO1 DCLK1 PHLDB2	2.55e-04	197	58	5	int:SRGAP2
Interaction	HSPA6 interactions	NEK4 RCOR1 BRD4 ATXN3 MCM5 FAF1	2.65e-04	311	58	6	int:HSPA6
Interaction	MYH9 interactions	NEK4 RCOR1 BRD4 ATXN3 SMC4 GIGYF2 MCM5 HUWE1 FAF1	2.82e-04	754	58	9	int:MYH9
Interaction	NCAPG interactions	RCOR1 POLD1 BRD4 SMC4 HUWE1	2.87e-04	202	58	5	int:NCAPG
Interaction	PARP1 interactions	NEK4 GTF2E1 POLD1 BRD4 ATXN3 SMC4 MCM5 NUDCD3 HUWE1 FLG2 NLRP2 FAF1	3.08e-04	1316	58	12	int:PARP1
Interaction	SMC2 interactions	CCP110 RCOR1 BRD4 SMC4 GIGYF2 HUWE1	3.25e-04	323	58	6	int:SMC2
Interaction	RTKN interactions	GIGYF2 DCLK1 PHLDB2 CLASRP	3.37e-04	115	58	4	int:RTKN
Interaction	NEURL4 interactions	CCP110 BRD4 ODF2 SPAG5	3.48e-04	116	58	4	int:NEURL4
Interaction	ABCA12 interactions	NEK4 BRD4	3.61e-04	10	58	2	int:ABCA12
Interaction	FANCI interactions	BRD4 ATXN3 PIDD1 MCM5 HUWE1	3.66e-04	213	58	5	int:FANCI
Interaction	CAPN1 interactions	POLD1 SYNE1 BRD4 ATXN3 HUWE1	3.82e-04	215	58	5	int:CAPN1
Interaction	B4GALT2 interactions	CCP110 RCOR1 HOOK2 TAF1	3.83e-04	119	58	4	int:B4GALT2
Interaction	WHAMMP3 interactions	BLOC1S5 SYNE1 HOOK2 SPAG5	3.83e-04	119	58	4	int:WHAMMP3
Interaction	WRNIP1 interactions	POLD1 BRD4 TAF1 HUWE1	3.83e-04	119	58	4	int:WRNIP1
Interaction	AIFM1 interactions	NEK4 STK10 ATAD3B POLD1 ATXN3 PIDD1 HUWE1 MEX3C	4.17e-04	629	58	8	int:AIFM1
Interaction	NUP107 interactions	EZR RCOR1 POLD1 SYNE1 HUWE1	4.33e-04	221	58	5	int:NUP107
Interaction	DDX23 interactions	PPIG GTF2E1 SYNE1 BRD4 SMC4 TAF1 CLASRP	4.38e-04	480	58	7	int:DDX23
Interaction	PHF21A interactions	RCOR1 BRD4 GIGYF2 TAF1 HUWE1 SPAG5	4.47e-04	343	58	6	int:PHF21A
Interaction	PYGL interactions	EZR BRD4 MCM5 HUWE1	4.62e-04	125	58	4	int:PYGL
Interaction	SH3PXD2A interactions	NEK4 GIGYF2 DCLK1 PHLDB2	5.05e-04	128	58	4	int:SH3PXD2A
GeneFamily	Ataxins\|MJD deubiquinating enzymes	ATXN3L ATXN3	2.31e-05	4	36	2	997
CoexpressionAtlas	facebase_RNAseq_e8.5_FloorPlate_2500_K3	NEK4 CCP110 PPIG C22orf23 BRD4 PPM1L SMC4 PIDD1 ROBO1 APLP1 MCM5 TNNT2 FAF1 CCDC40	1.41e-05	1371	58	14	facebase_RNAseq_e8.5_FloorPlate_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_500_k-means-cluster#4	NEK4 EZR SMC4 ODF2 CCDC40	2.24e-05	124	58	5	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_500_K4
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_1000	EZR CCP110 GPBP1 C22orf23 POLD1 PPM1L ATXN3 PIDD1 GIGYF2 TNNT2 CCDC40	6.74e-05	994	58	11	Facebase_RNAseq_e8.5_Floor Plate_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_2500_k-means-cluster#5	NEK4 DHX36 PPIG PPM1L SMC4 APLP1 CFAP210 HUWE1 ODF2 SPAG5	7.57e-05	831	58	10	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	NEK4 GPBP1 SMC4 GIGYF2 ODF2 SPAG5 CCDC40 UTP14C	9.39e-05	532	58	8	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3	NEK4 SMC4 CFAP210 ODF2 SPAG5	1.78e-04	192	58	5	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2	NEK4 DHX36 PPIG SMC4 ODF2 SPAG5	2.01e-04	311	58	6	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#5	NEK4 SMC4 ODF2 CCDC40 UTP14C	2.36e-04	204	58	5	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_1000_K5
CoexpressionAtlas	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4	CCP110 PPIG BRD4 PPM1L SMC4 PIDD1 APLP1 ODF2 DCLK1 FAF1 SPAG5 CCDC40	2.76e-04	1370	58	12	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000	NEK4 EZR DHX36 PPIG PPM1L SMC4 APLP1 CFAP210 ODF2 SPAG5	3.13e-04	989	58	10	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	PPM1L HOOK2 TNNT2 PDZRN3 PHLDB2	5.62e-06	189	60	5	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Stem_cells-Stem_cells\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	POLD1 DAAM2 MCM5 CFAP210 SPAG5	7.04e-06	198	60	5	50f236ab7ef6f00721f6cd714e3eee183077beeb
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Stem_cells\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	POLD1 DAAM2 MCM5 CFAP210 SPAG5	7.04e-06	198	60	5	dc0c6189ff9dd76675f63acf1cbc7dda60e75f3f
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)--\|Striatum / BrainAtlas - Mouse McCarroll V32	SLC9A8 ATXN3 GIGYF2 CCDC40	7.95e-05	169	60	4	5375eb52ebadccb7bfff997a11985f23e81014d6
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)\|Striatum / BrainAtlas - Mouse McCarroll V32	SLC9A8 ATXN3 GIGYF2 CCDC40	7.95e-05	169	60	4	c3bf0cb67f200d02d5a021754e9b2a68d23ea168
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)-\|Striatum / BrainAtlas - Mouse McCarroll V32	SLC9A8 ATXN3 GIGYF2 CCDC40	7.95e-05	169	60	4	1c132d21255f5a5174ac38db4e91927f9093418e
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIDD1 MCM5 CBFB UTP14C	8.32e-05	171	60	4	bf475a69db04d4a886e442704955c6a96ff0de46
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NEK4 ARHGAP31 CFAP210 CCDC40	8.90e-05	174	60	4	a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKD2 ROBO1 DAAM2 PDZRN3	9.10e-05	175	60	4	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EZR POLD1 CPLX2 PIDD1	9.72e-05	178	60	4	9b932b677ae05ac6e12cd6ce97789f8c10e4790b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TNNT2 PDZRN3 DNAH14 PHLDB2	9.93e-05	179	60	4	8766a5a066091879f521acfc612abf563ff78808
ToppCell	Ciliated_cells-A-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	NEK4 GTF2E1 C22orf23 CFAP210	9.93e-05	179	60	4	1c41314b6fcfcac8d62034e7037570120d58f20f
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PKD2 ROBO1 DAAM2 PDZRN3	1.01e-04	180	60	4	01f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell	P28-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SMC4 PIDD1 MCM5 SPAG5	1.04e-04	181	60	4	e482fd116c00ff4d8db7be3c06b1bd1ffa2d479d
ToppCell	P28-Endothelial-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SMC4 PIDD1 MCM5 SPAG5	1.04e-04	181	60	4	2be3d44619adb25d339e7a27b500a56e07e8de01
ToppCell	Control-T/NK-proliferating_T/NK\|Control / Disease group,lineage and cell class （2021.01.30）	SMC4 APOA1 SPAG5 NPIPA8	1.08e-04	183	60	4	e740f05536d1e4b2512811771928eb65f6696409
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EZR APLP1 TNNT2 CARNS1	1.13e-04	185	60	4	11fbea1eb1d9a3e4480d0d2b0f7b02e2866b8142
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	APOA1 TNFRSF10A DCLK1 SPAG5	1.15e-04	186	60	4	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SYNE1 PPM1L PHLDB2 MEX3C	1.17e-04	187	60	4	6981b856187a2e689260ecb7d0a1193a374ee9b9
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	MON2 RCOR1 GPBP1 HUWE1	1.20e-04	188	60	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EZR ARHGAP31 DAAM2 CARNS1	1.20e-04	188	60	4	505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCell	Epithelial-Epithelial-D_(Ciliated)\|Epithelial / shred on cell class and cell subclass (v4)	C22orf23 SYNE1 CFAP210 CCDC40	1.20e-04	188	60	4	8f30535a32968a81a304315a49c0d90a77d36948
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EZR ARHGAP31 DAAM2 CARNS1	1.22e-04	189	60	4	37ecbd73408d462b47d7e5611f203143e08a2689
ToppCell	MS-CD8-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	MON2 GTF2E1 NUDCD3 TNFRSF10A	1.25e-04	190	60	4	8c831c4560b8e70f92b4c15644fea39f7f7afcf2
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EZR ARHGAP31 DAAM2 CARNS1	1.25e-04	190	60	4	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EZR ARHGAP31 DAAM2 CARNS1	1.27e-04	191	60	4	f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCell	(04)_Pre-ciliated\|World / shred by cell type and Timepoint	CCP110 PIDD1 SPAG5 CCDC40	1.27e-04	191	60	4	37cf121e6e80760c8519075b7845b9029958a988
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EZR ARHGAP31 DAAM2 CARNS1	1.27e-04	191	60	4	a90c8ab2077e52bbc998457c85a1b9867f9c8c93
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EZR APLP1 TNNT2 CARNS1	1.30e-04	192	60	4	2f539653a20006bef814e6b4acd1023d6fdad5c6
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ROBO1 DAAM2 PDZRN3 DCLK1	1.33e-04	193	60	4	549a0b750c860b615aff767ad04c9a9d20f802f0
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKD2 ROBO1 DAAM2 PDZRN3	1.35e-04	194	60	4	8fae8061b350336299aa81f378e07deadbd55123
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKD2 ROBO1 DAAM2 PDZRN3	1.35e-04	194	60	4	4d7d24390fdb379f943ddcc70a63f23955e10163
ToppCell	facs-Thymus-nan-3m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLD1 PIDD1 MCM5 SPAG5	1.38e-04	195	60	4	93c345e70d6c8ff5d12fd63d73228c1700b804a0
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EZR APLP1 TNNT2 CARNS1	1.41e-04	196	60	4	429de4119c8b2193c992d36a6af84f806730cbee
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EZR APLP1 TNNT2 CARNS1	1.41e-04	196	60	4	8c8a73d9d9581b8d9a9babfa93459d12fb9eb3ac
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|GI_small-bowel / Manually curated celltypes from each tissue	PPM1L SMC4 APOA1 MEX3C	1.41e-04	196	60	4	5755ca4abcae3717894bbf7cbd49bca0a3a03067
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PKD2 ROBO1 PDZRN3 DCLK1	1.41e-04	196	60	4	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo\|GI_small-bowel / Manually curated celltypes from each tissue	PPM1L SMC4 APOA1 MEX3C	1.41e-04	196	60	4	181f3c1af565355b29f20ca6074147c313ca3477
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	ROBO1 PDZRN3 DCLK1 PHLDB2	1.44e-04	197	60	4	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	mLN-B_cell-B_cell_cycling\|B_cell / Region, Cell class and subclass	RCOR1 PPM1L CFAP210 SPAG5	1.44e-04	197	60	4	2071526fe46de8359ea118ff78581eb4454aa55a
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	ROBO1 PDZRN3 DCLK1 PHLDB2	1.44e-04	197	60	4	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SYNE1 PPM1L PHLDB2 MEX3C	1.46e-04	198	60	4	2fdb92b198ba24e326e90479fd024400d956fb32
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_dorsal_progenitors\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	EZR SMC4 ODF2 SPAG5	1.46e-04	198	60	4	5f0964c3aa7e1dc52cbb46e754078920b65bcb88
ToppCell	(0)_NK_cells-(0)_NK_Dividing\|(0)_NK_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	POLD1 SMC4 MCM5 SPAG5	1.46e-04	198	60	4	d9cdbc7d420472cb1ffb36ad9c8e53a61b7dbdeb
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PKD2 ROBO1 PDZRN3 DCLK1	1.46e-04	198	60	4	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SYNE1 PPM1L PHLDB2 MEX3C	1.46e-04	198	60	4	326e97bdc27cc3440f5488c2519446580cdc9d51
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	EZR SMC4 ODF2 SPAG5	1.46e-04	198	60	4	629d674a9c9108c1acb3f7af57bbdbf34bb0528e
ToppCell	(0)_NK_Dividing\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	POLD1 SMC4 MCM5 SPAG5	1.46e-04	198	60	4	5ebb4965b723302152b42bfaf48bb77a57dd02c5
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ROBO1 DAAM2 APLP1 CARNS1	1.49e-04	199	60	4	6fb5f931e6217142de38c1fffc011e63bda4772b
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ROBO1 DAAM2 APLP1 CARNS1	1.49e-04	199	60	4	5d2e85e40b6b52b1809e680b952913d77215b3d0
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DAAM2 TNNT2 PDZRN3 PHLDB2	1.49e-04	199	60	4	3835452e4848d7f7dd8651c17b746b271ef39688
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ROBO1 DAAM2 APLP1 CARNS1	1.49e-04	199	60	4	1bb5797e8e0552bf9b44bf4c958d1aa6dbe6c756
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ROBO1 DAAM2 APLP1 CARNS1	1.49e-04	199	60	4	9dd4b17fb8c70ab9e126b23b72600463f3db832d
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SYNE1 PDZRN3 DCLK1 PHLDB2	1.52e-04	200	60	4	b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	POLD1 SMC4 MCM5 SPAG5	1.52e-04	200	60	4	31dd81df9aa754a1e69b905bf9b8ce73ff8175aa
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ROBO1 PDZRN3 DCLK1 PHLDB2	1.52e-04	200	60	4	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Macroglial\|World / cells hierarchy compared to all cells using T-Statistic	EZR ARHGAP31 DAAM2 CARNS1	1.52e-04	200	60	4	e6935ad49216d2500c15c05cbc2b89402c65e838
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SYNE1 PDZRN3 DCLK1 PHLDB2	1.52e-04	200	60	4	3dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SYNE1 PDZRN3 DCLK1 PHLDB2	1.52e-04	200	60	4	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PKD2 PDZRN3 DCLK1 PHLDB2	1.52e-04	200	60	4	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	356C-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	POLD1 SMC4 MCM5 SPAG5	1.52e-04	200	60	4	97e47eb69d1d4cab45256acca9589837eb7817e7
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	PKD2 ROBO1 DAAM2 PDZRN3	1.52e-04	200	60	4	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells-Neuroepithelial_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	POLD1 SMC4 MCM5 SPAG5	1.52e-04	200	60	4	54174a485a82480726fa06efa6e050ddea77cb3c
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ELFN1 APOA1 TNFRSF10A SPAG5	1.52e-04	200	60	4	77ae679c35d3b9e2b620f34129f3a8d47e922c65
Disease	Machado-Joseph disease (implicated_via_orthology)	ATXN3L ATXN3	2.04e-05	4	55	2	DOID:1440 (implicated_via_orthology)
Disease	Polycystic kidney disease, type 2	BRD4 PKD2	7.12e-05	7	55	2	C2751306
Disease	Polycystic Kidney, Type 1 Autosomal Dominant Disease	BRD4 PKD2	9.48e-05	8	55	2	C0887850
Disease	Polycystic Kidney, Autosomal Dominant	BRD4 PKD2	1.22e-04	9	55	2	C0085413
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 HOOK2	2.22e-04	12	55	2	DOID:11726 (implicated_via_orthology)
Disease	schizophrenia (implicated_via_orthology)	ELFN1 CPLX2 GIGYF2	2.82e-04	68	55	3	DOID:5419 (implicated_via_orthology)
Disease	Alopecia, Male Pattern	BRD4 TNFRSF10A	3.53e-04	15	55	2	C4083212
Disease	Androgenetic Alopecia	BRD4 TNFRSF10A	3.53e-04	15	55	2	C0162311
Disease	Female pattern alopecia (disorder)	BRD4 TNFRSF10A	3.53e-04	15	55	2	C0263477
Disease	Pseudopelade	BRD4 TNFRSF10A	5.72e-04	19	55	2	C0086873
Disease	Alopecia	BRD4 TNFRSF10A	5.72e-04	19	55	2	C0002170
Disease	left ventricular structural measurement	TNNT2 PDZRN3 FAF1	6.01e-04	88	55	3	EFO_0008205
Disease	lobe attachment	ROBO1 DAAM2 DCLK1 PHLDB2	6.06e-04	207	55	4	EFO_0007667
Disease	Parkinson disease	ATXN3 GIGYF2	7.69e-04	22	55	2	cv:C0030567
Disease	Carcinoma, Granular Cell	ROBO1 APOA1 TNFRSF10A	1.34e-03	116	55	3	C0205644
Disease	Adenocarcinoma, Tubular	ROBO1 APOA1 TNFRSF10A	1.34e-03	116	55	3	C0205645
Disease	Adenocarcinoma, Oxyphilic	ROBO1 APOA1 TNFRSF10A	1.34e-03	116	55	3	C0205642
Disease	Carcinoma, Cribriform	ROBO1 APOA1 TNFRSF10A	1.34e-03	116	55	3	C0205643
Disease	Adenocarcinoma, Basal Cell	ROBO1 APOA1 TNFRSF10A	1.34e-03	116	55	3	C0205641
Disease	Adenocarcinoma	ROBO1 APOA1 TNFRSF10A	1.34e-03	116	55	3	C0001418

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLSRRRHKEEEEFMA	ELFN1	781	P0C7U0
RAEVDEEHRKAMERL	BLOC1S5	156	Q8TDH9
EHAEKEKERLRQERM	BRD4	1246	O60885
EHEGFLRAKMDLEER	APLP1	306	P51693
FDMTEHRRDEENARL	CARNS1	441	A5YM72
EMRDRARAHVDALRT	APOA1	171	P02647
MKDDLRHTRANAERD	CCDC113	111	Q9H0I3
MDRHARKQKREREES	RCOR1	246	Q9UKL0
LLRRDVEAHMRDACD	PDZRN3	121	Q9UPQ7
EHKHEIERMARADRF	DAAM2	731	Q86T65
LREMEDIDHRRSEEL	C22orf23	196	Q9BZE7
VIMHMLDRDHDRRLD	FLG2	56	Q5D862
EFDKMREDDRVAIHE	MCM5	446	P33992
HMARQDDEKRRQELE	NUDCD3	71	Q8IVD9
RRLRGHTDMEAELED	SLC2A7	241	Q6PXP3
AELEDMRAEARAERA	SLC2A7	251	Q6PXP3
KRDRVEEEHEDESRA	GPBP1	306	Q86WP2
RERDVRIRHLEMDFE	HOOK2	636	Q96ED9
IAHQLDEEERMRMAE	ATXN3	36	P54252
DMELEHFDERDKAQR	DCLK1	6	O15075
IAHQLDEEERMRMAE	ATXN3L	36	Q9H3M9
REFEDRDRSHREEME	CBFB	151	Q13951
DEFDREVRLREHMGE	NEK4	806	P51957
RMDLSERAKDEVREA	NLRP2	81	Q9NX02
VFERMVAEDERHRDI	MON2	176	Q7Z3U7
ERLDEGLRKEDMAVH	HUWE1	4006	Q7Z6Z7
EEKRMRSRSKGRDHE	PPIG	481	Q13427
LRMEEEAARLRHEEE	GIGYF2	866	Q6Y7W6
EAERQERAVVHMDER	DHX36	76	Q9H2U1
RHAMASSERRQKEEE	CCDC40	351	Q4G0X9
ERMSILHHDREVRKE	CCP110	881	O43303
RAREEEMQTKRDRFH	DNAH14	2246	Q0VDD8
ADRMAALRAKEELER	EZR	391	P15311
ADRAKREAHEREMAE	FAF1	521	Q9UNN5
REAHEREMAEQFRLE	FAF1	526	Q9UNN5
HDEEHEKLFDLVRRM	CLK4	441	Q9HAZ1
HDRMDCKGLEAVRRD	POLD1	821	P28340
EERKAKHARMEAERE	CPLX2	46	Q6PUV4
RHEFRDDLDEQIRHM	PIDD1	821	Q9HB75
EKMREDRDSLVERLH	ODF2	481	Q5BJF6
SMKEREHREEERQVS	NPIPA7	151	E9PJI5
SMKEREHREEERQVS	NPIPA8	151	P0DM63
KLDHMRRRIETDERD	GTF2E1	106	P29083
KAEREEARHREEMAL	SPAG5	561	Q96R06
EARHREEMALRGKDA	SPAG5	566	Q96R06
GEAERLRKEIHDHME	SYNE1	3781	Q8NF91
LFDEQHREEMRKERR	TAF1	1211	P21675
DRAREEIEMHIAMRT	MEX3C	381	Q5U5Q3
RRDHMEDRFEVLTDL	PPM1L	101	Q5SGD2
IRLMDIEDAKAHRRN	SLC9A8	471	Q9Y2E8
HAEKTRLLESREREM	PHLDB2	1046	Q86SQ0
EKERLRHLDMEHERL	MSANTD4	236	Q8NCY6
RATVEREMELRHKNE	ATAD3B	171	Q5T9A4
KREEMHESRRRFLEH	CFAP210	261	Q0VFZ6
HERQEREDELRAMAR	CLASRP	606	Q8N2M8
LEEAKMHRAELQRAR	UTP14C	216	Q5TAP6
KMEQDHAVRRREEAR	STK10	626	O94804
DGERVDFDDIHRKRM	TNNT2	91	P45379
EERVVKLRHSEREMR	SMC4	801	Q9NTJ3
RQEERRAEMKTRHDE	PTTG1IP	146	P53801
RARAEAVLLHEMDED	ARHGAP31	631	Q2M1Z3
ERVETDKDDPRSHRM	ROBO1	106	Q9Y6N7
DERLGRDSEIHREQM	PKD2	891	Q13563
ALERMEERHAREKIQ	TNFRSF10A	431	O00220