Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontriacylglycerol lipase activity

PNLIPRP1 PNLIPRP2 LIPG

7.00e-0626293GO:0004806
GeneOntologyMolecularFunctionGABA-gated chloride ion channel activity

GABRR1 GABRR2

3.07e-0418292GO:0022851
GeneOntologyMolecularFunctionGABA-A receptor activity

GABRR1 GABRR2

3.43e-0419292GO:0004890
GeneOntologyMolecularFunctionGABA receptor activity

GABRR1 GABRR2

4.62e-0422292GO:0016917
GeneOntologyMolecularFunctionlipase activity

PNLIPRP1 PNLIPRP2 LIPG

1.03e-03138293GO:0016298
GeneOntologyMolecularFunctioncarboxylic ester hydrolase activity

PNLIPRP1 PNLIPRP2 LIPG

1.50e-03157293GO:0052689
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

GABRR1 GABRR2

2.39e-0350292GO:0099095
GeneOntologyCellularComponentGABA-A receptor complex

GABRR1 GABRR2

3.13e-0419292GO:1902711
GeneOntologyCellularComponentGABA receptor complex

GABRR1 GABRR2

3.84e-0421292GO:1902710
DomainLipase_LIPH

PNLIPRP1 PNLIPRP2 LIPG

3.60e-0710283IPR016272
DomainLipase

PNLIPRP1 PNLIPRP2 LIPG

3.60e-0710283PF00151
DomainLipase_N

PNLIPRP1 PNLIPRP2 LIPG

3.60e-0710283IPR033906
DomainLipase/vitellogenin

PNLIPRP1 PNLIPRP2 LIPG

3.60e-0710283IPR013818
DomainTAG_lipase

PNLIPRP1 PNLIPRP2 LIPG

3.60e-0710283IPR000734
DomainGABAAa_rho_rcpt

GABRR1 GABRR2

2.17e-062282IPR008057
DomainLH2

PNLIPRP1 PNLIPRP2 LIPG

2.43e-0618283SM00308
DomainPLAT

PNLIPRP1 PNLIPRP2 LIPG

3.94e-0621283PF01477
DomainPLAT

PNLIPRP1 PNLIPRP2 LIPG

3.94e-0621283PS50095
DomainPLAT/LH2_dom

PNLIPRP1 PNLIPRP2 LIPG

3.94e-0621283IPR001024
Domain-

PNLIPRP1 PNLIPRP2 LIPG

3.94e-06212832.60.60.20
DomainLIPASE_SER

PNLIPRP1 PNLIPRP2 LIPG

7.67e-0626283PS00120
DomainLipase_panc

PNLIPRP1 PNLIPRP2

1.30e-054282IPR002331
DomainGABAA/Glycine_rcpt

GABRR1 GABRR2

5.38e-0423282IPR006028
Domain-

PNLIPRP1 PNLIPRP2 LIPG

7.35e-041192833.40.50.1820
DomainAB_hydrolase

PNLIPRP1 PNLIPRP2 LIPG

7.35e-04119283IPR029058
DomainNeurotransmitter_ion_chnl_CS

GABRR1 GABRR2

2.06e-0345282IPR018000
DomainNeur_chan_memb

GABRR1 GABRR2

2.15e-0346282PF02932
DomainNeur_chan_LBD

GABRR1 GABRR2

2.25e-0347282PF02931
DomainNeur_channel

GABRR1 GABRR2

2.25e-0347282IPR006201
DomainNeur_chan_lig-bd

GABRR1 GABRR2

2.25e-0347282IPR006202
DomainNEUROTR_ION_CHANNEL

GABRR1 GABRR2

2.25e-0347282PS00236
DomainNeurotrans-gated_channel_TM

GABRR1 GABRR2

2.25e-0347282IPR006029
Domain-

GABRR1 GABRR2

2.25e-03472822.70.170.10
DomainHelicase_C

CHD2 EIF4A2

1.12e-02107282PF00271
DomainHELICc

CHD2 EIF4A2

1.12e-02107282SM00490
DomainHelicase_C

CHD2 EIF4A2

1.14e-02108282IPR001650
DomainHELICASE_CTER

CHD2 EIF4A2

1.16e-02109282PS51194
DomainHELICASE_ATP_BIND_1

CHD2 EIF4A2

1.16e-02109282PS51192
DomainDEXDc

CHD2 EIF4A2

1.16e-02109282SM00487
DomainHelicase_ATP-bd

CHD2 EIF4A2

1.18e-02110282IPR014001
PathwayREACTOME_CREB3_FACTORS_ACTIVATE_GENES

CREBRF MBTPS1

2.54e-055232MM15513
PathwayREACTOME_DIGESTION_OF_DIETARY_LIPID

PNLIPRP1 PNLIPRP2

3.80e-056232MM14738
PathwayREACTOME_DIGESTION_OF_DIETARY_LIPID

PNLIPRP1 PNLIPRP2

5.32e-057232M27069
PathwayKEGG_GLYCEROLIPID_METABOLISM

PNLIPRP1 PNLIPRP2 LIPG

6.66e-0549233M15902
PathwayREACTOME_CREB3_FACTORS_ACTIVATE_GENES

CREBRF MBTPS1

9.10e-059232M27773
PathwayREACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR

CREBRF MBTPS1

1.66e-0412232MM14981
PathwayREACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR

CREBRF MBTPS1 DCTN1

4.47e-0493233M10294
PathwayREACTOME_DIGESTION

PNLIPRP1 PNLIPRP2

5.25e-0421232MM15526
PathwayREACTOME_DIGESTION

PNLIPRP1 PNLIPRP2

6.31e-0423232M27790
PathwayREACTOME_DIGESTION_AND_ABSORPTION

PNLIPRP1 PNLIPRP2

7.47e-0425232MM15557
PathwayREACTOME_DIGESTION_AND_ABSORPTION

PNLIPRP1 PNLIPRP2

9.38e-0428232M27837
PathwayREACTOME_PLASMA_LIPOPROTEIN_REMODELING

MBTPS1 LIPG

1.38e-0334232M27842
Pubmed

Elimination of the rho1 subunit abolishes GABA(C) receptor expression and alters visual processing in the mouse retina.

GABRR1 GABRR2

6.71e-07229212019334
Pubmed

Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms.

GABRR1 GABRR2

6.71e-07229228660714
Pubmed

The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.

GABRR1 GABRR2

6.71e-0722929153229
Pubmed

GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence.

GABRR1 GABRR2

6.71e-07229219536785
Pubmed

Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase.

PNLIPRP1 PNLIPRP2

2.01e-0632922302735
Pubmed

Pancreatic lipase and its related proteins: where are we now?

PNLIPRP1 PNLIPRP2

2.01e-06329238081381
Pubmed

GABAC receptors are functionally expressed in the intermediate zone and regulate radial migration in the embryonic mouse neocortex.

GABRR1 GABRR2

2.01e-06329220123002
Pubmed

Cloning and characterization of mouse GABA(C) receptor subunits.

GABRR1 GABRR2

2.01e-0632929507960
Pubmed

Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.

GABRR1 GABRR2

2.01e-06329210542332
Pubmed

GABAC receptor sensitivity is modulated by interaction with MAP1B.

GABRR1 GABRR2

2.01e-06329211102469
Pubmed

Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity.

PNLIPRP1 PNLIPRP2

2.01e-0632921379598
Pubmed

Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.

GABRR1 GABRR2

2.01e-0632929839716
Pubmed

Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.

GABRR1 GABRR2

4.02e-06429220820800
Pubmed

Developmentally regulated expression of GABA receptor rho1 and rho2 subunits, L7 and cone-rod homeobox (CRX) genes in mouse retina.

GABRR1 GABRR2

4.02e-06429211520487
Pubmed

ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.

GABRR1 GABRR2

6.70e-06529212431995
Pubmed

PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1.

GABRR1 GABRR2

6.70e-06529218325784
Pubmed

A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells.

GABRR1 GABRR2

1.41e-0572928940147
Pubmed

Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4.

GABRR1 GABRR2

1.41e-0572921315307
Pubmed

Mouse thioredoxin gene maps on chromosome 4, whereas its pseudogene maps on chromosome 1.

GABRR1 GABRR2

1.87e-0582928088797
Pubmed

Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size.

GABRR1 GABRR2

2.41e-05929215883645
Pubmed

Phosphorylation of the recombinant rho1 GABA receptor.

GABRR1 GABRR2

2.41e-05929212175859
Pubmed

Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder.

GABRR1 GABRR2

3.01e-051029220583128
Pubmed

Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing.

GABRR1 GABRR2

3.01e-051029230902970
Pubmed

Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts.

GABRR1 GABRR2

6.07e-05142928649829
Pubmed

Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.

GABRR1 GABRR2

1.02e-041829219078961
Pubmed

The essential player in adipogenesis GRP78 is a novel KCTD15 interactor.

ACTBL2 EHD2

2.69e-042929229665387
Pubmed

RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.

RBM6 POLR1A ACTBL2

4.73e-0418329328186131
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

OXSM USPL1 LIPG ACTBL2

8.29e-0451329425798074
Cytoband10q25.3

PNLIPRP1 PNLIPRP2

1.55e-042929210q25.3
Cytoband6q15

GABRR1 GABRR2

1.77e-04312926q15
CytobandEnsembl 112 genes in cytogenetic band chr6q15

GABRR1 GABRR2

4.82e-0451292chr6q15
CytobandEnsembl 112 genes in cytogenetic band chr10q25

PNLIPRP1 PNLIPRP2

3.12e-03131292chr10q25
GeneFamilyGamma-aminobutyric acid type A receptor subunits

GABRR1 GABRR2

1.58e-0419182563
GeneFamilyLipases|Arylacetamide deacetylase family

PNLIPRP2 LIPG

2.14e-0422182464
CoexpressionGSE29617_CTRL_VS_DAY3_TIV_FLU_VACCINE_PBMC_2008_UP

CREBRF CHD2 LIPG RABGGTB EIF4A2

1.90e-06196285M4928
CoexpressionGSE17974_0.5H_VS_72H_IL4_AND_ANTI_IL12_ACT_CD4_TCELL_UP

MBTPS1 CHD2 POLR1A USPL1

5.39e-05196284M4244
CoexpressionGSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN

USPL1 EMC4 RABGGTB MAMLD1

5.83e-05200284M6671
ToppCellfacs-Aorta-Heart-3m-Epithelial|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIPRP1 VWA7 ACTBL2 KLB

2.71e-06151294bee48137d1f5f27a24571a59c835284651d38538
ToppCellfacs-Aorta-Heart-3m-Epithelial-epithelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIPRP1 VWA7 ACTBL2 KLB

2.71e-061512940de76acd1b204345dce7f33be2a1ed9fbe9e6da0
ToppCellfacs-Aorta-Heart-3m-Epithelial-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIPRP1 VWA7 ACTBL2 KLB

2.71e-0615129420b9c8fb966c5d62ff909cc4a4616b109b78cdca
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chrnb3_(interneuron,_Lateral_Geniculate_Nucleus__(LGN))--|Thalamus / BrainAtlas - Mouse McCarroll V32

GABRR1 GABRR2 PNLIPRP2

1.84e-05792935c37af70dca7e9847f44d7f5969d4b06c32b4ca0
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chrnb3_(interneuron,_Lateral_Geniculate_Nucleus__(LGN))|Thalamus / BrainAtlas - Mouse McCarroll V32

GABRR1 GABRR2 PNLIPRP2

1.84e-057929375d8cbf8c7a6a4a825143f7d04a604e97bab0fe5
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chrnb3_(interneuron,_Lateral_Geniculate_Nucleus__(LGN))-|Thalamus / BrainAtlas - Mouse McCarroll V32

GABRR1 GABRR2 PNLIPRP2

1.84e-0579293d4f9297084aea33203dd98d7f6f837b6eb00b6c3
ComputationalNeighborhood of SERPINI2

PNLIPRP1 PNLIPRP2

7.77e-0425182GNF2_SERPINI2
ComputationalNeighborhood of SPINK1

PNLIPRP1 PNLIPRP2

9.07e-0427182GNF2_SPINK1
Drugtributyrin

DNAJB1 PNLIPRP1 PNLIPRP2 LIPG

1.10e-0664284CID000006050
Drug1,2,3-trioleoylglycerol

OXSM PNLIPRP1 PNLIPRP2 LIPG

1.00e-05111284CID000031207
Drugtricaprylin

PNLIPRP1 PNLIPRP2 LIPG

1.72e-0541283CID000010850
Drugpropanidid

PNLIPRP1 PNLIPRP2 LIPG

3.74e-0553283CID000015004
Drugtripropionin

PNLIPRP1 PNLIPRP2

6.52e-0510282CID000008763
DrugAC1L5176

PNLIPRP2 LIPG

7.97e-0511282CID000168098
Drug1b9v

MBTPS1 OXSM DCTN1

8.27e-0569283CID000444508
DrugZaprinast [37762-06-4]; Up 200; 14.8uM; PC3; HT_HG-U133A

BNC1 GABRR2 LIPG CCDC40

9.65e-051982846749_UP
DiseaseN-acetylcarnosine measurement

GABRR1 GABRR2

2.25e-058272EFO_0022101
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GABRR1 GABRR2

9.23e-0449272DOID:0060037 (implicated_via_orthology)
DiseaseHDL cholesterol change measurement, physical activity

RBM6 LIPG

1.47e-0362272EFO_0003940, EFO_0007805
Diseasesmoking status measurement

BNC1 OR5A2 MBTPS1 POLR1A INSYN1

3.65e-031160275EFO_0006527
Diseaseplatelet component distribution width

RBM6 VWA7 CCDC40 MAMLD1

4.67e-03755274EFO_0007984
Diseaseloneliness measurement

PNLIPRP1 PNLIPRP2

5.74e-03124272EFO_0007865
Diseasefatty acid measurement

LIPG FERMT3 KLB

7.20e-03436273EFO_0005110
Diseasephospholipid measurement

PNLIPRP2 LIPG

7.26e-03140272EFO_0004639
Diseasediabetic nephropathy

GABRR1 GABRR2

8.29e-03150272EFO_0000401

Protein segments in the cluster

PeptideGeneStartEntry
FMPDSFLRPGGDHDC

DCTN1

591

Q14203
GFGGDDAPRAVFPSM

ACTBL2

21

Q562R1
VSGMDPPFGDAFRSH

CREBRF

6

Q8IUR6
GGAFEGTHMGPFVER

EHD2

411

Q9NZN4
GTHMGPFVERGPDEA

EHD2

416

Q9NZN4
DGGHEHYFTPGMEPQ

BNC1

651

Q01954
GEEGMDIDDPFSGFP

DNAJB1

121

P25685
KAGMGGPFDLGHLDF

INSYN1

86

Q2T9L4
PFHPKRDGFVMGEGA

OXSM

266

Q9NWU1
LSIGGPDFMDHPFVD

MBTPS1

306

Q14703
HLDFFPNGGESMPGC

PNLIPRP1

241

P54315
MERDPGISHGGPFIF

OR5A2

306

Q8NGI9
GLDPAGPMFEGADIH

LIPG

191

Q9Y5X9
GGFADRPGDMVDPFH

RABGGTB

276

P53611
IDDHDFSMRPGFGGP

GABRR1

81

P24046
DHRPAMGYHGQGPSD

CHD2

1746

O14647
MAEPGGAAGRSHPED

CCDC40

1

Q4G0X9
ADYNREHGGPEGMDP

EIF4A2

6

Q14240
EDHFQFPDMADGGYP

MAMLD1

66

Q13495
ANPIHGDGDYPEGMR

KLB

331

Q86Z14
AFIEPPERMEFSGGG

EMC4

166

Q5J8M3
VDEHDFSMRPAFGGP

GABRR2

61

P28476
GHLDFFPNGGKEMPG

PNLIPRP2

241

P54317
HSGDFRDREGPPMDY

RBM6

121

P78332
PPEFFFHCMAGREGL

POLR1A

961

O95602
SPFGHGLRPVDVGFM

SEPTIN5

161

Q99719
GDFRYLGMGDSHIPP

USPL1

991

Q5W0Q7
AGPGFPAALHDFEMS

SOGA1

1086

O94964
GGVAPALFRGMPAHF

FERMT3

171

Q86UX7
FGDDHRSAPMDPQGV

TRIM64C

311

A6NLI5
LDFLFHFGIPMEDGP

VWA7

601

Q9Y334