Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsyntaxin-1 binding

UNC13B SYT1

2.34e-0424192GO:0017075
GeneOntologyMolecularFunctionmolecular sensor activity

UHRF1 SYT1

1.02e-0350192GO:0140299
GeneOntologyMolecularFunctionmethylated histone binding

CBX3 UHRF1

2.99e-0386192GO:0035064
GeneOntologyMolecularFunctionsyntaxin binding

UNC13B SYT1

3.06e-0387192GO:0019905
GeneOntologyMolecularFunctionmethylation-dependent protein binding

CBX3 UHRF1

3.13e-0388192GO:0140034
GeneOntologyMolecularFunctioncalcium-dependent protein binding

A2M SYT1

3.86e-0398192GO:0048306
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP44 USP24

5.19e-03114192GO:0004843
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate binding

SYT1 SNX14

5.82e-03121192GO:1902936
GeneOntologyMolecularFunctiondeubiquitinase activity

USP44 USP24

6.10e-03124192GO:0101005
GeneOntologyMolecularFunctionSNARE binding

UNC13B SYT1

7.30e-03136192GO:0000149
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP44 USP24

7.40e-03137192GO:0019783
GeneOntologyBiologicalProcessregulation of calcium ion-dependent exocytosis of neurotransmitter

UNC13B SYT1

1.34e-056202GO:1903233
GeneOntologyBiologicalProcessspontaneous neurotransmitter secretion

UNC13B SYT1

5.86e-0512202GO:0061669
GeneOntologyBiologicalProcessspontaneous synaptic transmission

UNC13B SYT1

1.35e-0418202GO:0098814
GeneOntologyBiologicalProcesscalcium ion-regulated exocytosis of neurotransmitter

UNC13B SYT1

2.64e-0425202GO:0048791
MousePhenoabnormal lactate dehydrogenase level

COG2 NDUFS3 UBE3C

4.66e-0559173MP:0002943
DomainUSP_CS

USP44 USP24

2.24e-0366202IPR018200
DomainUSP_1

USP44 USP24

2.52e-0370202PS00972
DomainUCH

USP44 USP24

2.59e-0371202PF00443
DomainUSP_2

USP44 USP24

2.59e-0371202PS00973
DomainUSP_3

USP44 USP24

2.66e-0372202PS50235
DomainUSP_dom

USP44 USP24

2.66e-0372202IPR028889
DomainPeptidase_C19_UCH

USP44 USP24

2.66e-0372202IPR001394
DomainIg_E-set

A2M EBF3

5.47e-03104202IPR014756
DomainC2

UNC13B SYT1

8.54e-03131202PF00168
DomainC2

UNC13B SYT1

9.31e-03137202SM00239
DomainC2

UNC13B SYT1

9.97e-03142202PS50004
Domain-

UNC13B SYT1

1.08e-021482022.60.40.150
DomainC2_dom

UNC13B SYT1

1.31e-02164202IPR000008
PathwayREACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

1.84e-0417172M93
PathwayREACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

1.84e-0417172MM14907
PathwayREACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

2.07e-0418172M27043
PathwayREACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

2.07e-0418172M13015
PathwayREACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

2.07e-0418172MM14702
PathwayREACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

2.07e-0418172MM14703
PathwayREACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

3.41e-0423172MM14852
PathwayREACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

3.41e-0423172M12627
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

3.72e-0424172M630
PathwayREACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

3.72e-0424172MM14834
PathwayWP_SYNAPTIC_VESICLE_PATHWAY

UNC13B SYT1

1.69e-0351172M39457
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

1.69e-0351172MM14499
PathwayREACTOME_NEUROTRANSMITTER_RELEASE_CYCLE

UNC13B SYT1

1.69e-0351172M4281
PathwayWP_16P112_PROXIMAL_DELETION_SYNDROME

UNC13B MVP

3.70e-0376172M40057
Pubmed

The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling.

UHRF1 GPNMB

3.14e-07220238789534
Pubmed

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

UNC13B SYT1

1.88e-06420229068313
Pubmed

Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.

UNC13B SYT1

3.14e-06520229274147
Pubmed

Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.

UNC13B SYT1

6.59e-0672028999968
Pubmed

Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer.

UHRF1 UBE3C

1.41e-051020236376892
Pubmed

SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming.

UNC13B SYT1

1.41e-051020221040848
Pubmed

An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.

A2M COG2

1.72e-051120219105203
Pubmed

The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.

UNC13B SYT1

1.72e-051120225374362
Pubmed

The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells.

CBX3 UHRF1

1.72e-051120233097091
Pubmed

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

CBX3 UHRF1

3.75e-051620228803780
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

CBX3 UHRF1 TXNDC16 UTP20 SNX14 MADD

4.28e-05120120635696571
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

SYT1 MGAT4C COG2 NDUFS3 SLC25A21 USP24

5.16e-05124220630973865
Pubmed

Proteomic screen defines the hepatocyte nuclear factor 1alpha-binding partners and identifies HMGB1 as a new cofactor of HNF1alpha.

CBX3 SNX14

5.34e-051920218160415
Pubmed

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.

USP44 USP24

7.21e-052220226811477
Pubmed

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.

USP44 USP24

7.89e-052320214715245
Pubmed

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.

UNC13B SYT1

1.01e-042620217124501
Pubmed

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.

CBX3 UHRF1 NDUFS3

2.46e-0421520330462309
Pubmed

Protein profile of exosomes from trabecular meshwork cells.

A2M MVP

3.64e-044920221362503
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

A2M CBX3 UHRF1 MVP

4.67e-0465220431180492
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

CBX3 MVP UTP20 USP24

4.70e-0465320422586326
Pubmed

Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.

UBE3C USP24

5.09e-045820231067491
CytobandEnsembl 112 genes in cytogenetic band chr7p15

CBX3 GPNMB

8.87e-04101202chr7p15
CytobandEnsembl 112 genes in cytogenetic band chr12q21

SYT1 MGAT4C

1.72e-03141202chr12q21
CytobandEnsembl 112 genes in cytogenetic band chr11p11

NDUFS3 MADD

2.02e-03153202chr11p11
GeneFamilyUbiquitin specific peptidases

USP44 USP24

8.37e-0456142366
CoexpressionGSE36888_UNTREATED_VS_IL2_TREATED_STAT5_AB_KNOCKIN_TCELL_2H_DN

UNC13B A2M UHRF1 UTP20

1.34e-05196204M8757
ToppCellHippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)|Hippocampus / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21 GPNMB

6.27e-0681203a0b45dc22077805eba94689568b874415f515d61
ToppCellHippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21 GPNMB

6.27e-06812032c58dbad21e0fbe46b005bcaf45139d098a2057a
ToppCellHippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--|Hippocampus / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21 GPNMB

6.27e-0681203571884bcf4282053c6170609ae0c794a6df05cd9
ToppCellEntopeduncular-Macroglia-ASTROCYTE|Entopeduncular / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21 GPNMB

2.53e-05129203c37bdd6c0b2944fbfa064922954ea0e263160e2a
ToppCellEntopeduncular-Macroglia-ASTROCYTE-Gja1|Entopeduncular / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21 GPNMB

2.53e-051292038648ae59f7aca0f5b4983bdb4a65b03b2ca761e1
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21 GPNMB

2.84e-05134203a632d78890fcc20db81d2cf6b299470706d2e182
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21 GPNMB

2.84e-051342038be2db71d9d29f9a57a64efdc89cf8c3e32b363b
ToppCellCerebellum-Macroglia-ASTROCYTE|Cerebellum / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21 GPNMB

4.05e-0515120371841d2001200d1595c85c2b007ee20791a72927
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1|Cerebellum / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21 GPNMB

4.05e-0515120360aced0c1cc6b509b73308d03d58a3c44d712ef4
ToppCell10x3'2.3-week_14-16-Myeloid_macrophage-stroma-erythroid_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

A2M SYT1 NEXMIF

5.09e-05163203240d9f0ea45e8b2c7173e7674fd740555810f9e7
ToppCelldroplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B UHRF1 MADD

5.47e-05167203bad33497ceeab968a7eb8a48b921c6f936390743
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UHRF1 UTP20 GPNMB

6.39e-05176203450c25ec5eeb65425f904e0a25aaafdf5682ef9c
ToppCell18-Distal-Epithelial-Epithelial|Distal / Age, Tissue, Lineage and Cell class

EBF3 SYT1 MGAT4C

7.41e-05185203d2a266724f3f70f746a78034f308d98f8b7a66e3
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CBX3 SNX14 USP24

7.77e-051882036468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CBX3 SNX14 USP24

7.77e-051882037a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CBX3 SNX14 USP24

7.77e-051882039cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCelldroplet-Tongue-nan-24m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CBX3 UHRF1 GPNMB

7.89e-05189203258ef4a52f90236dbed92f325ca033c8fa6156a5
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_early|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

UNC13B USP44 UHRF1

7.89e-05189203a6c62b456982067ad4d224a2efa3919969000693
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M EBF3 SYT1

8.14e-0519120304c7aa2e39fdd08ca24c10d43b29a5e41a73b9e0
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M EBF3 SYT1

8.14e-05191203db8dd6bbba803585bdd6a55d5c403d383f2e9acf
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EBF3 SYT1 MGAT4C

8.14e-051912032c51850f5c559d665b8a27a12b75af9ed58dffe1
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M EBF3 SYT1

8.40e-051932033a9fe4e709c09ec787c71bdd6b58a71c419896de
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EBF3 SYT1 MGAT4C

8.53e-05194203c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-midbrain/hindbrain_cells|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

EBF3 SYT1 MGAT4C

8.79e-051962030767581b69bc7e6334d580ca02ed1e831b7b55da
ToppCellASK440-Epithelial-Type_2|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

UNC13B USP44 MVP

8.92e-0519720308d5bbeb77a4152af1c783bc958afcae24667767
ToppCell(5)_Dendritic_cell-(52)_cycling_DCs|(5)_Dendritic_cell / shred on Cell_type and subtype

A2M UHRF1 GPNMB

9.19e-05199203d0ff446a197062b10f37b585f3f8716d6d89e5b7
ToppCellFrontal_cortex-Neuronal|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SYT1 NEXMIF MADD

9.19e-05199203f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCellSigmoid-Dendritic_cell-cycling_DCs|Dendritic_cell / Region, Cell class and subclass

A2M UHRF1 GPNMB

9.33e-05200203372fe9018481a4e9ac6ab3af43705a48238c4376
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Cortical_neuron|10w / Sample Type, Dataset, Time_group, and Cell type.

EBF3 SYT1 MGAT4C

9.33e-0520020368c90376e2779434e4ad8dc6dd3b44baa700e2f4
ToppCellTransverse-(5)_Dendritic_cell-(52)_cycling_DCs|Transverse / shred on region, Cell_type, and subtype

A2M UHRF1 GPNMB

9.33e-0520020351e643d48b5e97a0e117b578a6ea7d429c6cdd1e
ToppCellTransverse-Dendritic_cell-cycling_DCs|Transverse / Region, Cell class and subclass

A2M UHRF1 GPNMB

9.33e-05200203f588d8889f351c797963616a3575fa43efd46b9a
ToppCell(52)_cycling_DCs|World / shred on Cell_type and subtype

A2M UHRF1 GPNMB

9.47e-05201203ad2d25d84345fdd593065516a05c5c2b5429eac0
ToppCellPosterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

4.33e-04692028e14f411cbaea9cb9bcb9351b2421e71d5828ccc
ToppCellPosterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

4.33e-04692022fd6df70cdc7477e4a3ebdf4537279a727ab1214
ToppCellPosterior_cortex-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

4.33e-0469202bc3170409d107c39534581d2f0b8d75f93519113
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Myoc)--|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

6.56e-0485202786258a945fd9c67d473fc66d4b6c147cb9dfd86
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Myoc)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

6.56e-0485202d004ba0fbef8b4d07b5b26e6b935c793d52431e0
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Myoc)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

6.56e-04852027bb9cd33f2131ac0d3aa6b13b0ffa2ee8cbff8c6
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

7.34e-049020272b800d26f1f06540fff35a57c23ca453b51edd8
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

7.34e-0490202cd2424a1b0a9264e91731691bda34dbd73867971
ToppCellSubstantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

7.34e-0490202c96d653ab7761ecc0cd0835a5fc8ae6f9b151210
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-OPC_related|GW09 / Sample Type, Dataset, Time_group, and Cell type.

EBF3 UTP20

7.51e-049120225197fde8b9bdaf1e28add695d13aff3ff52d86e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-OPC_related-Oligodendrocyte/OPC|GW09 / Sample Type, Dataset, Time_group, and Cell type.

EBF3 UTP20

7.51e-0491202ed4a48e5e5f5d8aadbc7b1b8d84a5f6363a08b85
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

A2M GPNMB

7.84e-04932026d91b52147fb68461b39223e52026f2a02dcda7f
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

A2M GPNMB

7.84e-0493202d6409351d89f6289411bac4aff65322e91212e57
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

A2M GPNMB

7.84e-0493202d736a59d48fa0dc41afef67f1a1507105558e47c
ToppCellThalamus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)|Thalamus / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

9.23e-041012021d74f6b30d23e942f26fc57665b5c533ff0c089f
ToppCellThalamus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--|Thalamus / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

9.23e-04101202578946c048084f48a74d4352743017f04039d5e8
ToppCellThalamus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-|Thalamus / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

9.23e-041012028a3b8abe06a8c5b546ce40c9429401058fe671d7
ToppCellFrontal_cortex-Macroglia-ASTROCYTE|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

9.79e-04104202bf27bc52f440d1e94108b35ad85ed593201164c9
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

9.79e-0410420210e6c5b63c28d8c47e89ab130a7daf01700dd4e4
ToppCellGlobus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Gfap_(Gfap)--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC25A21 GPNMB

9.97e-04105202c41264e8b7d306d5d3ffa5b29eb36c7131d1cedf
ToppCellGlobus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Gfap_(Gfap)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC25A21 GPNMB

9.97e-04105202ed570cfdd452767dfb4dcae72282fe0fb25a4029
ToppCellGlobus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Gfap_(Gfap)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC25A21 GPNMB

9.97e-04105202ed3a431195c42c96c7d9c420e4b9fb00f415012d
ToppCellPosterior_cortex-Macroglia-ASTROCYTE|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

1.13e-031122021c0bcc6c972c50a9d950cd56b65efb8d778ec25a
ToppCellPosterior_cortex-Macroglia-ASTROCYTE-Gja1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

1.13e-03112202e30cd0b7b755c63081bbeed4e1a884b6640d34f8
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Gfap)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

SLC25A21 GPNMB

1.15e-03113202c0b8d7a2e3722029e850051bdff77f31f34a8cca
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Gfap)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

SLC25A21 GPNMB

1.15e-03113202fed408864201218295bac0cc6647953fda8d688e
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Gfap)|Cerebellum / BrainAtlas - Mouse McCarroll V32

SLC25A21 GPNMB

1.15e-031132027e24c0f6a80e10a2a41325d48a87628bd330a1e2
ToppCellThalamus-Macroglia-ASTROCYTE|Thalamus / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

1.32e-03121202c3a4dfd19b7e8654e859df605d55155b530ad009
ToppCellThalamus-Macroglia-ASTROCYTE-Gja1|Thalamus / BrainAtlas - Mouse McCarroll V32

A2M SLC25A21

1.32e-03121202c3efd44bd01c12ef8c7ce4cc351af1540b70a63c
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Nts|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MGAT4C GPNMB

1.45e-03127202ace2944328529fa029ee56c7ad3b0f283511d3bb
ToppCellBronchial_Biopsy-Mesenchymal-Fibroblasts|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

A2M GPNMB

1.50e-0312920213cd10ffdd8f1ef7721884e9efd2cf25f170f414
ToppCellE16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_smooth_muscle-like|E16.5-samps / Age Group, Lineage, Cell class and subclass

MVP SYT1

1.57e-031322029633653dba1edee47d915212fb6e68426da49de5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M EBF3

1.74e-03139202b07929348ec9ad95d7bce33a7deac0938227b19f
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Tall_Cell-4|TCGA-Thryoid / Sample_Type by Project: Shred V9

SYT1 GPNMB

1.81e-0314220243524c10f446c9da079cff52800326a1d4675452
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

SYT1 MGAT4C

1.96e-03148202d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_VISp_Trhr_Cpne7|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

UNC13B MGAT4C

1.99e-031492028638b3819193d11411df58964069fec583f617f4
ToppCell356C-Myeloid-Macrophage-SPP1+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

A2M GPNMB

1.99e-03149202a6c24d8f3b5f08587f0a12cd63d166b68ea000c7
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-NP|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

UNC13B MGAT4C

2.07e-03152202b6a7453fbf9f898e4f222b215907c9a110baa2f6
ToppCellfacs-Trachea-24m-Hematologic-myeloid-granulocyte-granulocyte_l8|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYT1 MGAT4C

2.10e-03153202338684d420b01e32918fa19048ccdda234942ce1
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEXMIF GPNMB

2.12e-031542021e32969bee810adaf2d560f0824a16227df513d8
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

UHRF1 MADD

2.18e-03156202ff39712c7a2dc1b85c598d5105789aa291dea726
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D122|Adult / Lineage, Cell type, age group and donor

UNC13B USP44

2.21e-0315720231d1bd9138c60e8485664ec4144f987226e3eef9
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B GPNMB

2.23e-03158202f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B GPNMB

2.23e-031582028c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UTP20 GPNMB

2.23e-031582026811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M GPNMB

2.26e-03159202d9e535cf9a0a2302268f2897b010dcecc6426e41
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M GPNMB

2.26e-0315920229999c87f5823f734e5cbf8ea8b729ec017db9b3
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

SYT1 MGAT4C

2.26e-031592025335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.0.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M GPNMB

2.26e-031592024b840da854390f8285c219314cff4434d7ffcacc
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|367C / Donor, Lineage, Cell class and subclass (all cells)

UTP20 UBE3C

2.32e-03161202f470b662566131dfe69a2fd01186ac8491196396
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M SYT1

2.35e-03162202c7114e24cb5525abb9780ca3d35dbcc4eabd4b64
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UTP20 GPNMB

2.35e-03162202d712bc31840ad1523e3dbf884acbb428a8995001
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M SYT1

2.35e-03162202f1851a173d3bcca2981d934161ec85d1cc0af5a2
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M SYT1

2.35e-031622025d902bb31e691aea9749617cc88303c2448f24b8
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M EBF3

2.37e-031632021feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCellCOVID-mono3|COVID / Condition, Cell_class and T cell subcluster

A2M GPNMB

2.37e-031632026ab4cbcd411b40920b81162c0f4b03ea67408f52
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

A2M EBF3

2.37e-03163202977a970b1296234c22178420294cea73506ee02f
ToppCellCOVID-mono3-|COVID / Condition, Cell_class and T cell subcluster

A2M GPNMB

2.37e-0316320226661c7a3a0a449ed32d4b3b28fc2fc0b237025d
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

A2M EBF3

2.37e-03163202ba7d02db0f0e2f9916ec8db52c067c87b6917c23
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYT1 MGAT4C

2.40e-03164202be49af6335f2505065cde2cb9800e4a5516811b1
ToppCellfacs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M SLC25A21

2.43e-031652024f95c2fe5ab4416c736fe0d1936695a2b26777eb
ToppCellEndothelial-endothelial_cell_of_bronchial_vessel|World / Lineage, Cell type, age group and donor

A2M EBF3

2.43e-0316520284e553d699ac56df89a77248f7308b9133e1b683
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

USP44 NEXMIF

2.43e-03165202f6887c64af0f26e33316bc5587487e24d76ece2a
ToppCellfacs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M SLC25A21

2.43e-031652023e913b49a868fdd5589200ae3e9be77c0938ba14
ToppCelldroplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UHRF1 SLC25A21

2.46e-03166202b7f303203068b205f382788815df487a0ea148ed
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M EBF3

2.46e-031662028e2faca6a2e76a625de04d6098aa6f98911945c6
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEXMIF GPNMB

2.49e-03167202cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M GPNMB

2.49e-031672022dc3de562a26077cb76855b725cf278a272d3276
DiseaseKidney Failure, Acute

A2M GPNMB

2.12e-03101202C0022660
DiseaseAcute Kidney Insufficiency

A2M GPNMB

2.12e-03101202C1565662
DiseaseAcute kidney injury

A2M GPNMB

2.12e-03101202C2609414
Diseaseneuroticism measurement, cognitive function measurement

UHRF1 SYT1 NDUFS3

6.28e-03566203EFO_0007660, EFO_0008354
Diseaseprostate specific antigen measurement

A2M SLC25A21

7.11e-03188202EFO_0004624
Diseasealcohol use disorder (implicated_via_orthology)

UNC13B MADD

7.63e-03195202DOID:1574 (implicated_via_orthology)
Diseasephospholipids:total lipids ratio

MADD USP24

1.02e-02227202EFO_0020946

Protein segments in the cluster

PeptideGeneStartEntry
EPEEFVVEKVLDRRV

CBX3

26

Q13185
VKDVYVVTDQIPVFV

GPNMB

226

Q14956
VEEFVLPKFEVQVTV

A2M

221

P01023
GDVFVIVFENPIIIK

MGAT4C

376

Q9UBM8
LTEAIVVNPFEVVKV

SLC25A21

121

Q9BQT8
VFVLEEFVPEIKEVV

MADD

1591

Q8WXG6
TFEIPVIKIESFVVE

DDX58

881

O95786
YIPRKEVEVVEIIQA

MVP

151

Q14764
LVKPYIDEVIIEQFV

COG2

251

Q14746
PVEIERTAFVDFVEK

EBF3

81

Q9H4W6
FEVPFEQIQKVQVVV

SYT1

346

P21579
KVVNDEEVVRVPLAF

UTP20

1811

O75691
VLPVFEEETRIFQKD

NEXMIF

1501

Q5QGS0
VKRVVAEPVELAQEF

NDUFS3

216

O75489
VVFKRAEEGVPVEFL

TXNDC16

321

Q9P2K2
IDKIRFDPFIVEEIQ

SNX14

406

Q9Y5W7
NKPEIFEVIRDVFTV

UNC13B

561

O14795
IIFVDEVFKIERPGE

UHRF1

271

Q96T88
VIEDPIQVERVKFVF

USP24

2461

Q9UPU5
QEEPFQEKIVVKREV

USP44

176

Q9H0E7
FVVPFEERVKIFQRL

UBE3C

691

Q15386