Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessprotein localization to centrosome

C2CD3 MCPH1 BICD1

2.50e-0538313GO:0071539
GeneOntologyBiologicalProcessprotein localization to microtubule organizing center

C2CD3 MCPH1 BICD1

2.71e-0539313GO:1905508
GeneOntologyBiologicalProcessdetermination of left/right symmetry

PCSK5 CER1 C2CD3 DISP1

8.04e-05154314GO:0007368
GeneOntologyBiologicalProcessprotein localization to microtubule cytoskeleton

C2CD3 MCPH1 BICD1

9.44e-0559313GO:0072698
GeneOntologyBiologicalProcessleft/right pattern formation

PCSK5 CER1 C2CD3 DISP1

9.78e-05162314GO:0060972
GeneOntologyBiologicalProcessdetermination of bilateral symmetry

PCSK5 CER1 C2CD3 DISP1

1.05e-04165314GO:0009855
GeneOntologyBiologicalProcessspecification of symmetry

PCSK5 CER1 C2CD3 DISP1

1.05e-04165314GO:0009799
GeneOntologyBiologicalProcessprotein localization to cytoskeleton

C2CD3 MCPH1 BICD1

1.15e-0463313GO:0044380
GeneOntologyBiologicalProcessphosphatidylinositol 3-kinase/protein kinase B signal transduction

LRP2 PREX2 STAMBP GAB4 EPHA8

2.43e-04382315GO:0043491
HumanPhenoThin corpus callosum

LRP2 ZNF526 C2CD3 MCPH1 NSD2 DISP1 STAMBP

1.07e-0486897HP:0033725
HumanPhenoAbnormal corpus callosum morphology

LRP2 ZNF526 C2CD3 MCPH1 NSD2 DISP1 STAMBP

1.78e-0493797HP:0001273
HumanPhenoAgenesis of corpus callosum

LRP2 C2CD3 MCPH1 NSD2 DISP1

1.82e-0436595HP:0001274
HumanPhenoSloping forehead

ZNF526 C2CD3 MCPH1 STAMBP

1.96e-0418894HP:0000340
HumanPhenoAbnormal cortical gyration

ZNF526 C2CD3 MCPH1 DISP1 STAMBP

2.44e-0438895HP:0002536
HumanPhenoDysplastic corpus callosum

LRP2 C2CD3 MCPH1 NSD2 DISP1

2.65e-0439595HP:0006989
DomainPH_dom-like

OSBPL7 OSBPL6 FRMPD3 FGD6 FRMD1 PREX2 FRMPD2 GAB4

5.78e-07426338IPR011993
DomainEGF

LRP2 PCSK5 NRG2 SNED1 THBS3 MEGF10

3.10e-06235336SM00181
DomainEGF-like_dom

LRP2 PCSK5 NRG2 SNED1 THBS3 MEGF10

4.33e-06249336IPR000742
DomainEGF-like_CS

LRP2 NRG2 SNED1 THBS3 MEGF10 EPHA8

5.67e-06261336IPR013032
DomainEGF_2

LRP2 NRG2 SNED1 THBS3 MEGF10 EPHA8

6.19e-06265336PS01186
DomainPH

OSBPL7 OSBPL6 FGD6 PREX2 GAB4

4.76e-05229335PF00169
DomainEGF_3

LRP2 NRG2 SNED1 THBS3 MEGF10

5.38e-05235335PS50026
Domain-

OSBPL7 OSBPL6 FGD6 PREX2 FRMPD2 GAB4

5.56e-053913362.30.29.30
DomainFERM_M

FRMPD3 FRMD1 FRMPD2

7.24e-0546333PF00373
DomainEGF_1

LRP2 NRG2 SNED1 THBS3 MEGF10

7.92e-05255335PS00022
DomainFERM_central

FRMPD3 FRMD1 FRMPD2

8.76e-0549333IPR019748
DomainFERM_domain

FRMPD3 FRMD1 FRMPD2

8.76e-0549333IPR000299
DomainFERM_1

FRMPD3 FRMD1 FRMPD2

9.31e-0550333PS00660
DomainFERM_2

FRMPD3 FRMD1 FRMPD2

9.31e-0550333PS00661
DomainBand_41_domain

FRMPD3 FRMD1 FRMPD2

9.31e-0550333IPR019749
DomainB41

FRMPD3 FRMD1 FRMPD2

9.31e-0550333SM00295
DomainFERM_3

FRMPD3 FRMD1 FRMPD2

9.31e-0550333PS50057
DomainPH

OSBPL7 OSBPL6 FGD6 PREX2 GAB4

1.19e-04278335SM00233
DomainPH_DOMAIN

OSBPL7 OSBPL6 FGD6 PREX2 GAB4

1.21e-04279335PS50003
DomainPH_domain

OSBPL7 OSBPL6 FGD6 PREX2 GAB4

1.23e-04280335IPR001849
DomainOxysterol_BP

OSBPL7 OSBPL6

1.98e-0412332PF01237
DomainOxysterol-bd

OSBPL7 OSBPL6

1.98e-0412332IPR000648
DomainOxysterol-bd_CS

OSBPL7 OSBPL6

1.98e-0412332IPR018494
DomainOSBP

OSBPL7 OSBPL6

1.98e-0412332PS01013
DomainEGF_Ca-bd_CS

LRP2 SNED1 THBS3

6.62e-0497333IPR018097
DomainEGF_CA

LRP2 SNED1 THBS3

7.02e-0499333PS01187
DomainEphrin_rec_like

PCSK5 EPHA8

8.85e-0425332SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

PCSK5 EPHA8

8.85e-0425332IPR011641
DomainFERM_C

FRMD1 FRMPD2

1.03e-0327332SM01196
DomainFERM_PH-like_C

FRMD1 FRMPD2

1.03e-0327332IPR018980
DomainhEGF

SNED1 MEGF10

1.11e-0328332PF12661
DomainEGF_CA

LRP2 SNED1 THBS3

1.29e-03122333SM00179
DomainEGF-like_Ca-bd_dom

LRP2 SNED1 THBS3

1.35e-03124333IPR001881
DomainEGF

LRP2 NRG2 SNED1

1.41e-03126333PF00008
DomainFERM_N

FRMD1 FRMPD2

1.54e-0333332IPR018979
DomainFERM_N

FRMD1 FRMPD2

1.54e-0333332PF09379
DomainPDZ

FRMPD3 PREX2 FRMPD2

1.95e-03141333PF00595
DomainPDZ

FRMPD3 PREX2 FRMPD2

2.23e-03148333SM00228
Domain-

FRMPD3 PREX2 FRMPD2

2.32e-031503332.30.42.10
DomainPDZ

FRMPD3 PREX2 FRMPD2

2.37e-03151333PS50106
DomainPDZ

FRMPD3 PREX2 FRMPD2

2.41e-03152333IPR001478
DomainGrowth_fac_rcpt_

LRP2 PCSK5 THBS3

2.59e-03156333IPR009030
DomainC2_dom

OSBPL6 C2CD3 INPP4A

2.99e-03164333IPR000008
Domain-

FRMD1 FRMPD2

3.38e-03493321.20.80.10
DomainFERM/acyl-CoA-bd_prot_3-hlx

FRMD1 FRMPD2

3.52e-0350332IPR014352
DomainUbiquitin-rel_dom

FRMPD3 FRMD1 FRMPD2

4.13e-03184333IPR029071
DomainEGF_extracell

LRP2 MEGF10

5.03e-0360332IPR013111
DomainEGF_2

LRP2 MEGF10

5.03e-0360332PF07974
DomainRhoGEF

FGD6 PREX2

6.41e-0368332SM00325
DomainDH_2

FGD6 PREX2

6.78e-0370332PS50010
DomainRhoGEF

FGD6 PREX2

6.78e-0370332PF00621
DomainDH-domain

FGD6 PREX2

6.97e-0371332IPR000219
Domain-

FGD6 PREX2

6.97e-03713321.20.900.10
Domain-

PCSK5 EPHA8

7.36e-03733322.60.120.260
Pubmed

Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7.

OSBPL7 OSBPL6

2.62e-06333214593528
Pubmed

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases.

PCSK5 TIMP4

1.31e-05633216135528
Pubmed

The OSBP-related protein family in humans.

OSBPL7 OSBPL6

4.78e-051133211483621
Pubmed

An oxysterol-binding protein family identified in the mouse.

OSBPL7 OSBPL6

5.73e-051233212215260
Pubmed

A family of 12 human genes containing oxysterol-binding domains.

OSBPL7 OSBPL6

5.73e-051233211735225
Pubmed

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.

PCSK5 CER1

1.04e-041633220876279
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

MCPH1 NSD2 INPP4A SGSM2 FRMPD2 NBPF1 BICD1

4.17e-04148933728611215
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

THAP8 PCSK5 C2CD3 NSD2 SGSM2 NBPF1

5.39e-04110533635748872
Pubmed

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

PCSK5 BICD1

6.33e-043933219010793
CytobandEnsembl 112 genes in cytogenetic band chr7q31

PNPLA8 GRM8

4.58e-03140332chr7q31
CytobandEnsembl 112 genes in cytogenetic band chr2q31

OSBPL6 LRP2

7.29e-03178332chr2q31
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

FRMPD3 FRMD1 FRMPD2

6.21e-05502831293
GeneFamilyOxysterol binding proteins|Pleckstrin homology domain containing

OSBPL7 OSBPL6

1.51e-0412282670
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

C2CD3 INPP4A

1.41e-0336282823
GeneFamilyPDZ domain containing

FRMPD3 PREX2 FRMPD2

1.64e-031522831220
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

OSBPL7 FGD6 GAB4

3.87e-03206283682
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

FGD6 PREX2

4.67e-0366282722
GeneFamilyFibronectin type III domain containing

SNED1 EPHA8

2.53e-02160282555
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 CER1 FRMPD3 GRM8 PREX2

2.82e-071913357b386512284dfaa0e95358b28ee82632ee965e64
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_Krt80|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 CER1 GRM8 DISP1

3.52e-0614133440ef6d792e11fe10963d64eb0b606b90556c1a70
ToppCellfrontal_cortex-Non-neuronal-astrocyte|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIMP4 FGD6 PREX2 MEGF10

5.40e-06157334803af734d7f775d294391e2b84e472a732e18cef
ToppCellfrontal_cortex-Non-neuronal-astrocyte-Astro|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIMP4 FGD6 PREX2 MEGF10

5.40e-061573340551442ae14685d8fe5729e3960c6324b1e05e4d
ToppCellfrontal_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIMP4 FGD6 PREX2 MEGF10

5.40e-061573349aa5304a9704da6dd4eda7d6940494b00e38b2e8
ToppCellfacs-MAT-Fat-3m-Epithelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSBPL7 TIMP4 MEGF10

4.46e-0593333dbfaa7f23d25f5c286ab7ca3ca795b734cb95153
ToppCellfacs-MAT-Fat-3m-Epithelial-epithelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSBPL7 TIMP4 MEGF10

4.46e-05933330d6d1d8dd9c91ba31eb35a4b5979d087890936c1
ToppCellfacs-MAT-Fat-3m-Epithelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSBPL7 TIMP4 MEGF10

4.46e-0593333abffb1fd5a919b7c08e62e1c3c08a8dd8783a4ca
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Cdh13|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 DISP1 LCE3C

1.38e-041363331f3000d5f105c87c80f8ae1dd2264bcd7f757a9c
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 DISP1 LCE3C

1.50e-041403337cc891d676555609add6fc7880735d948a2ad801
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|390C / Donor, Lineage, Cell class and subclass (all cells)

OSBPL7 FRMPD3 BICD1

1.60e-04143333d877d914e4e74db2053baa310d318d6440e672bc
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_3|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

FRMPD3 GGT6 EPHA8

1.63e-04144333ce5e219f2548b51440b8b3e1a9f011afd4510d19
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PCSK5 LCE3C EPHA8

1.63e-0414433308005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

OSBPL7 FRMPD3 BICD1

1.70e-041463331bf67a9416f52198931b912a31be4bab09fefd19
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIMP4 PREX2 MEGF10

1.95e-0415333395b28c5bd10ffb74c0993ebd565038b9818e4bd2
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIMP4 PREX2 MEGF10

1.95e-041533333ab9d55b3db51715c1d61eca142384195ce4b54f
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte-Astro|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIMP4 PREX2 MEGF10

1.95e-04153333b09f8def40a1ea56722f3398f61a036667b61cd9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SNED1 PREX2 MEGF10

2.19e-04159333d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCelldroplet-Limb_Muscle-nan-3m-Myeloid-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRG2 ZNF526 FGD6

2.48e-0416633335db3022c33d6f8bb6587d9eec89a7cccb70271a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF526 FRMPD2 NBPF1

2.48e-04166333c8fd241088de27c6e741a5dfee3cd770183b6bcb
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 THBS3 FGD6

2.71e-041713337c8304573b892ef9ea4e048cba9ea9fbab848dcd
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRM8 FGD6 FRMPD2

2.71e-041713339e00c8191ca9d52151a49baf39f8581cb176fb76
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 SGSM2 BICD1

2.85e-041743334da79da7a09ee1e345102c5331675ebcdbe56171
ToppCellBAL-Mild-cDC_3|Mild / Compartment, Disease Groups and Clusters

OSBPL7 THBS3 NBPF1

2.95e-04176333f9b0c3ced391e7ebe6b242d3f12ba14741f88d22
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

OSBPL6 LRP2 FRMD1

3.09e-04179333d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SNED1 GRM8 INPP4A

3.15e-04180333cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 SGSM2 BICD1

3.20e-04181333330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 SGSM2 BICD1

3.20e-041813333f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 PREX2 BICD1

3.30e-04183333351d575339038bd4a66f408da518c567444208e8
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP2 PREX2 MEGF10

3.35e-04184333a2191dd5546efd357b23e625beb3c5820476f243
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP2 PREX2 MEGF10

3.41e-04185333b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 FRMPD3 PREX2

3.41e-0418533308fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCellpdx|World / Sample and Cell Type and Tumor Cluster (all cells)

PCSK5 NSD2 BICD1

3.46e-04186333de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCellpdx-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

PCSK5 NSD2 BICD1

3.46e-041863330b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 THBS3 FRMPD3

3.46e-04186333cd6502bbf9dce318fdbb4965d49df8951e5f795c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CER1 GRM8 PREX2

3.46e-04186333310d16f4e5cffee3ea6d7635508c513a3b92131e
ToppCelldroplet-Lung-nan-18m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 THBS3 FRMPD3

3.46e-04186333b58db5abdd3e9f0214b198c3cbd09b0b3c321eab
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP2 PREX2 MEGF10

3.52e-0418733397e520705491c8f52a32025311a9fa7b9176979a
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 GGT6 PREX2

3.52e-041873333548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 GGT6 PREX2

3.52e-04187333f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

OSBPL6 LRP2 PCSK5

3.52e-04187333acd305475f3609800af0d7bc68d83ef41228080b
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 GGT6 PREX2

3.52e-0418733381754e965848b718be20ee97ce072ce426938a69
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 TIMP4 PREX2

3.52e-04187333e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CER1 GRM8 PREX2

3.57e-041883330501a8aa850bd2e347020abd1cac4d8075738189
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP2 PREX2 MEGF10

3.63e-0418933342ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GRM8 DISP1 PREX2

3.63e-04189333b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD3 GRM8 PREX2

3.63e-04189333f0aaf2994d319a39877d2845eaab9f166adead4e
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SNED1 TIMP4 BICD1

3.68e-041903333cf464664d6aa22b212e60b70885953887e92483
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP2 PREX2 MEGF10

3.68e-0419033307f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP2 PREX2 MEGF10

3.68e-04190333ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 GRM8 PREX2

3.74e-041913334b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CER1 GRM8 PREX2

3.74e-04191333fa50a3c7ff86e1ee07100da1ace0b0fa1b0ab26b
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 TIMP4 PREX2

3.74e-04191333b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP2 PREX2 MEGF10

3.74e-041913332b056cbe2e82e056e1f798974999378460eb1d16
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NRG2 SNED1 PREX2

3.80e-04192333c0e59e642b42c055cf73d029cf54d07d9b719359
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GRM8 GAB4 BICD1

3.86e-041933339661ea0ee7273928c7de2a9f49e853595fa77699
ToppCellLA|World / Chamber and Cluster_Paper

LRP2 PCSK5 BICD1

3.86e-04193333d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PCSK5 SNED1 DISP1

3.86e-041933332f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NRG2 SNED1 PREX2

3.86e-0419333352e918884877b6659cdca0496390e440f73694a9
ToppCellE17.5-Mesenchymal-myocytic_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 NRG2 MEGF10

3.97e-0419533301a750d660993017af00736215cbcff2de5909c1
ToppCellE17.5-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 NRG2 MEGF10

3.97e-041953331daddd801bd4596fffbdb822fc326d5127c96004
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SNED1 PREX2 BICD1

4.09e-04197333e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCellP03-Mesenchymal-myocytic_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

THBS3 TIMP4 MEGF10

4.09e-04197333079db904a08743b3c555cb7b3f5fb5c978dde25a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SNED1 PREX2 BICD1

4.09e-0419733385a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SNED1 FGD6 PREX2

4.22e-04199333d95d78b2ebc9a20532466e4d4be579b4faf6776f
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SNED1 FGD6 PREX2

4.22e-04199333cdcfca94baba66e213cc3ffb0cfb4c75d6ab44ec
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SNED1 FGD6 PREX2

4.28e-0420033368fce28690246895fd33354b30960ebcc31aa4cc
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SNED1 FGD6 PREX2

4.28e-04200333032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellMacroglial-Astrocytes-GFAP---|Macroglial / cells hierarchy compared to all cells using T-Statistic

SNED1 FRMPD2 BICD1

4.28e-0420033388d66550781a3c9102ff7455f5cff6fb072943cd
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PCSK5 GRM8 PREX2

4.28e-04200333d416a7be1a4e6232fb58a9687774da24821f1fdd
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Macroglial-Astrocyte|GW19 / Sample Type, Dataset, Time_group, and Cell type.

THBS3 PREX2 MEGF10

4.28e-042003337c66953ff6d8f16f4decd23c85232990d2d8c6c4
ToppCellMacroglial-Astrocytes-GFAP-|Macroglial / cells hierarchy compared to all cells using T-Statistic

SNED1 FRMPD2 BICD1

4.28e-04200333d6a059b0ef763c281c60b1ac76da6079ea822f80
ToppCellMacroglial-Astrocytes-GFAP--|Macroglial / cells hierarchy compared to all cells using T-Statistic

SNED1 FRMPD2 BICD1

4.28e-0420033316269fa4adb28fc6ed032bbdba8781237dd0d249
ToppCellMacroglial-Astrocytes-GFAP|Macroglial / cells hierarchy compared to all cells using T-Statistic

SNED1 FRMPD2 BICD1

4.28e-0420033379634b1086934412ae92f259ab43554ce545008f
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR|Neuronal / cells hierarchy compared to all cells using T-Statistic

PCSK5 GRM8 PREX2

4.28e-04200333862db57d043bdf3cb059fbfc8b29bc1eafdf64ec
ToppCellMacroglial-Astrocytes-GFAP----L1-2|Macroglial / cells hierarchy compared to all cells using T-Statistic

SNED1 FRMPD2 BICD1

4.28e-04200333c6f43bbbd5df5f2c19ae385f1a6b6a330abede2f
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SNED1 FGD6 PREX2

4.28e-04200333376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SNED1 FGD6 PREX2

4.28e-04200333878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GRM8 DISP1 PREX2

4.28e-04200333105c67e4f5eff036013d655c8e8ac577d32dae2e
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SNED1 FGD6 PREX2

4.28e-042003337136936d05ab344a560cf159684c881063b5430d
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SNED1 FGD6 PREX2

4.28e-042003337fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR--L1|Neuronal / cells hierarchy compared to all cells using T-Statistic

PCSK5 GRM8 PREX2

4.28e-04200333a91345f268f13170c27309333603eb82400c9947
DrugRapamycin; Down 200; 0.1uM; PC3; HT_HG-U133A

NRG2 FRMD1 INPP4A SGSM2 BICD1

7.49e-061963254445_DN
DrugDNA-PK Inhibitor III; Up 200; 1uM; PC3; HT_HG-U133A

OSBPL7 LRP2 INPP4A SGSM2

1.47e-041923247548_UP
DrugTrichlorfon [52-68-6]; Down 200; 15.6uM; MCF7; HT_HG-U133A

THBS3 INPP4A BICD1 DCAF7

1.49e-041933245989_DN
DrugLY 294002; Up 200; 10uM; HL60; HT_HG-U133A

OSBPL7 PCSK5 MCPH1 BICD1

1.52e-041943246195_UP
DrugHydroxyzine dihydrochloride [2192-20-3]; Down 200; 9uM; PC3; HT_HG-U133A

THBS3 GRM8 INPP4A SGSM2

1.52e-041943246660_DN
DrugPentoxifylline [6493-05-6]; Down 200; 14.4uM; MCF7; HT_HG-U133A

THBS3 GRM8 INPP4A PREX2

1.52e-041943246021_DN
DrugClofazimine [2030-63-9]; Up 200; 8.4uM; PC3; HT_HG-U133A

LRP2 MCPH1 NSD2 PREX2

1.55e-041953244682_UP
Drugestradiol, USP; Down 200; 0.01uM; HL60; HT_HG-U133A

LRP2 FRMD1 SGSM2 BICD1

1.55e-041953246200_DN
DrugHexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; HL60; HT_HG-U133A

NRG2 INPP4A PREX2 DCAF7

1.55e-041953242708_DN
DrugMethylergometrine maleate [113-42-8]; Up 200; 8.8uM; PC3; HT_HG-U133A

SNED1 MCPH1 FRMD1 INPP4A

1.59e-041963246704_UP
DrugParbendazole [14255-87-9]; Up 200; 16.2uM; PC3; HT_HG-U133A

LRP2 GRM8 TIMP4 INPP4A

1.59e-041963244535_UP
DrugAcetazolamide [59-66-5]; Down 200; 18uM; MCF7; HT_HG-U133A

THBS3 FGD6 BICD1 DCAF7

1.59e-041963241686_DN
DrugPralidoxime chloride [51-15-0]; Down 200; 23.2uM; MCF7; HT_HG-U133A

NRG2 THBS3 FGD6 INPP4A

1.62e-041973246443_DN
DrugNaftifine hydrochloride [65473-14-5]; Up 200; 12.4uM; HL60; HT_HG-U133A

THBS3 INPP4A PREX2 BICD1

1.62e-041973242974_UP
DrugLansoprazole [103577-45-3]; Down 200; 10.8uM; PC3; HT_HG-U133A

THBS3 C2CD3 FGD6 NSD2

1.62e-041973247306_DN
DrugGuanabenz acetate [23256-50-0]; Down 200; 13.8uM; PC3; HT_HG-U133A

NRG2 SNED1 GRM8 SGSM2

1.62e-041973244642_DN
DrugThyroxine (L) [51-48-9]; Up 200; 5.2uM; PC3; HT_HG-U133A

MCPH1 GRM8 FRMD1 INPP4A

1.62e-041973244069_UP
DrugPHA-00846566E [724718-26-7]; Up 200; 10uM; PC3; HT_HG-U133A

TIMP4 NSD2 INPP4A BICD1

1.62e-041973247046_UP
DrugFuraltadone hydrochloride [3759-92-0]; Up 200; 11uM; PC3; HT_HG-U133A

PCSK5 GRM8 INPP4A PREX2

1.65e-041983243756_UP
DrugHalcinonide [3093-35-4]; Down 200; 8.8uM; PC3; HT_HG-U133A

NRG2 NSD2 SGSM2 BICD1

1.65e-041983243680_DN
DrugOxaprozin [21256-18-8]; Down 200; 13.6uM; MCF7; HT_HG-U133A

LRP2 GRM8 FRMD1 INPP4A

1.65e-041983243876_DN
Drug11-deoxy-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A

NRG2 THBS3 NSD2 BICD1

1.65e-041983247519_DN
DrugBenzocaine [94-09-7]; Down 200; 24.2uM; HL60; HT_HG-U133A

THBS3 FRMD1 INPP4A PREX2

1.68e-041993242167_DN
DrugSuloctidil [54063-56-8]; Down 200; 11.8uM; PC3; HT_HG-U133A

THBS3 INPP4A PREX2 DCAF7

1.68e-041993246675_DN
Drug5162773; Up 200; 7uM; MCF7; HT_HG-U133A_EA

THBS3 GRM8 INPP4A BICD1

1.68e-04199324892_UP
DrugMepenzolate bromide [76-90-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A

NRG2 SNED1 GRM8 TIMP4

1.68e-041993246024_UP
DrugPanthenol (D) [81-13-0]; Up 200; 19.4uM; MCF7; HT_HG-U133A

LRP2 THBS3 FRMD1 BICD1

1.71e-042003247455_UP
DiseaseCFTR mutation carrier status

PCSK5 FRMD1

3.16e-0425312EFO_0021794
DiseaseChild Development Disorders, Specific

LRP2 STAMBP

4.26e-0429312C0085997
DiseaseChild Development Deviations

LRP2 STAMBP

4.26e-0429312C0085996
DiseaseDevelopmental Disabilities

LRP2 STAMBP

4.56e-0430312C0008073
Diseaseneuritic plaque measurement

OSBPL6 PCSK5 CER1 INPP4A

4.70e-04349314EFO_0006798
Diseasemacrophage colony stimulating factor measurement

PREX2 EPHA8

6.95e-0437312EFO_0008217
DiseaseGastrointestinal Stromal Sarcoma

C2CD3 DISP1

1.12e-0347312C3179349
DiseaseIntellectual Disability

LRP2 ZNF526 NSD2 INPP4A

1.18e-03447314C3714756
DiseaseGastrointestinal Stromal Tumors

C2CD3 DISP1

1.27e-0350312C0238198
Diseasecommon carotid intimal medial thickness

MCPH1 GRM8

2.26e-0367312EFO_0004860
DiseaseMicrocephaly

NSD2 STAMBP

2.26e-0367312C0025958
Diseasecreatinine measurement

LRP2 THBS3 INPP4A MEGF10 STAMBP

3.54e-03995315EFO_0004518
Diseaseresponse to anticonvulsant

DISP1 PREX2

3.61e-0385312GO_0036277
DiseaseKidney Diseases

LRP2 PCSK5

3.87e-0388312C0022658
Diseasetreatment-resistant hypertension

THBS3 GAB4

5.86e-03109312EFO_1002006
DiseaseMyopia

OSBPL6 PNPLA8 FRMPD2

7.56e-03385313HP_0000545

Protein segments in the cluster

PeptideGeneStartEntry
QPHSSSQCAPLHCLS

BICD1

956

Q96G01
PGAAQHSHTSCSHCL

CER1

196

O95813
HSHTSCSHCLPAKFT

CER1

201

O95813
CCHPCPYHHPLTSHS

DISP1

81

Q96F81
PYHHPLTSHSSHQEC

DISP1

86

Q96F81
PHSSCHICTAADDHQ

DCAF7

276

P61962
MPSTACHPHLTTHCS

INPP4A

601

Q96PE3
QTCPQCVHSSGPCHH

MEGF10

626

Q96KG7
HHHHDSDSNSPCCKR

MMTAG2

226

Q9BU76
SHHFPAAPLCRSECH

MCPH1

731

Q8NEM0
HCLHCCNTSDPPSAQ

PCSK5

1701

Q92824
LHSCVSCHASNPSNP

NSD2

761

O96028
SHSCSPSHHCSTATP

NRG2

496

O14511
SDEHNCPTHAPASCL

LRP2

1096

P98164
HREHTHPASVCSLPC

GRM8

506

O00222
CSNSHSPCDSNQPHK

NBPF1

211

Q3BBV0
QVSHHPPISACHCES

OSBPL6

671

Q9BZF3
VSSQHCPHCLSRHSA

FRMD1

376

Q8N878
CPHCLSRHSADSHGS

FRMD1

381

Q8N878
HPVACSFCPEFSHHV

C2CD3

1251

Q4AC94
ASSLTHSPESHPHLC

FRMPD2

1246

Q68DX3
CQSRSHSPSCQPHGH

FRMPD3

1171

Q5JV73
GLCSSPAEPSCSHQH

GAB4

171

Q2WGN9
EHAHVSSVPHACCPF

GGT6

476

Q6P531
HSHSAAPAAQACHCD

EPHA8

296

P29322
PSSESGCCLSHHRHF

LCE3C

46

Q5T5A8
PAHTCHCGVPACSHT

CRIPAK

321

Q8N1N5
SHHPPISACHAESEN

OSBPL7

581

Q9BZF2
SCSKHCYSPSNHGLH

PNPLA8

66

Q9NP80
PSCHQHLCSEHFTPS

THAP8

51

Q8NA92
SSPHATPSHCSCIPD

SGSM2

466

O43147
CHTDHNASHSLPSPC

SNED1

531

Q8TER0
HPHSKDPPLFCSCSH

STAMBP

396

O95630
PDHHSCHLQLPSDEC

FGD6

236

Q6ZV73
SCAPAHPQQHICHSA

TIMP4

31

Q99727
SPLHSSDFCPTNCHV

PREX2

926

Q70Z35
RTCHSPAHSPCHIHA

THBS3

416

P49746
HSPASATHPFHCSQC

ZNF526

296

Q8TF50