Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	epithelial tube morphogenesis	MST1 PRKD2 DEAF1 TMTC3 DVL3 PKHD1 MST1L FOXA1 FOXF1	2.67e-05	421	77	9	GO:0060562
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	4.12e-05	3	77	2	GO:0002879
GeneOntologyBiologicalProcess	regulation of mammary gland epithelial cell proliferation	MST1 DEAF1 MST1L	6.34e-05	21	77	3	GO:0033599
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	8.21e-05	4	77	2	GO:0002877
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	MST1 PRKD2 DEAF1 TMTC3 DVL3 PKHD1 MST1L FOXA1 FOXF1 FOXF2	9.90e-05	619	77	10	GO:0002009
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	1.37e-04	5	77	2	GO:0002525
GeneOntologyBiologicalProcess	morphogenesis of a polarized epithelium	DVL3 PKHD1 FOXF1 FOXF2	1.61e-04	73	77	4	GO:0001738
GeneOntologyBiologicalProcess	positive regulation of neuronal action potential	FFAR3 GPR42	2.04e-04	6	77	2	GO:1904457
GeneOntologyBiologicalProcess	mammary gland epithelial cell proliferation	MST1 DEAF1 MST1L	2.75e-04	34	77	3	GO:0033598
GeneOntologyBiologicalProcess	mammary gland epithelium development	MST1 DEAF1 MST1L FOXF1	2.76e-04	84	77	4	GO:0061180
GeneOntologyBiologicalProcess	synaptic vesicle uncoating	SH3GL2 SH3GL3	2.85e-04	7	77	2	GO:0016191
GeneOntologyBiologicalProcess	clathrin coat disassembly	SH3GL2 SH3GL3	3.80e-04	8	77	2	GO:0072318
GeneOntologyBiologicalProcess	tissue morphogenesis	MST1 PRKD2 DEAF1 TMTC3 DVL3 PKHD1 MST1L FOXA1 FOXF1 FOXF2	4.62e-04	750	77	10	GO:0048729
GeneOntologyBiologicalProcess	embryo implantation	MST1 ATR MST1L PTGIS	4.78e-04	97	77	4	GO:0007566
GeneOntologyBiologicalProcess	epithelial tube branching involved in lung morphogenesis	TMTC3 FOXA1 FOXF1	4.81e-04	41	77	3	GO:0060441
GeneOntologyBiologicalProcess	vesicle uncoating	SH3GL2 SH3GL3	4.87e-04	9	77	2	GO:0072319
GeneOntologyBiologicalProcess	positive regulation of mammary gland epithelial cell proliferation	MST1 MST1L	4.87e-04	9	77	2	GO:0033601
GeneOntologyBiologicalProcess	mammary duct terminal end bud growth	MST1 MST1L	4.87e-04	9	77	2	GO:0060763
GeneOntologyBiologicalProcess	regulation of heart rate by chemical signal	FFAR3 GPR42	4.87e-04	9	77	2	GO:0003062
GeneOntologyBiologicalProcess	establishment of planar polarity	DVL3 PKHD1 FOXF2	5.93e-04	44	77	3	GO:0001736
GeneOntologyCellularComponent	exocytic vesicle membrane	DMXL2 ATR SV2B SH3GL2 SV2C SYNPR SLC17A6	5.63e-06	179	80	7	GO:0099501
GeneOntologyCellularComponent	synaptic vesicle membrane	DMXL2 ATR SV2B SH3GL2 SV2C SYNPR SLC17A6	5.63e-06	179	80	7	GO:0030672
GeneOntologyCellularComponent	transport vesicle membrane	DMXL2 ATR SV2B SH3GL2 SV2C SYNPR SLC17A6	1.31e-04	293	80	7	GO:0030658
GeneOntologyCellularComponent	synaptic vesicle	DMXL2 ATR SV2B SH3GL2 SV2C SYNPR SLC17A6	1.52e-04	300	80	7	GO:0008021
GeneOntologyCellularComponent	exocytic vesicle	DMXL2 ATR SV2B SH3GL2 SV2C SYNPR SLC17A6	2.25e-04	320	80	7	GO:0070382
GeneOntologyCellularComponent	transport vesicle	DMXL2 ATR SV2B SH3GL2 SV2C MFRP SYNPR SLC17A6	8.28e-04	519	80	8	GO:0030133
Domain	BRINP	BRINP3 BRINP2	5.42e-05	3	80	2	IPR033237
Domain	SV2	SV2B SV2C	5.42e-05	3	80	2	IPR022308
Domain	Pentapeptide_4	SV2B SV2C	5.42e-05	3	80	2	PF13599
Domain	GPR40-rel_orph	FFAR3 GPR42	1.08e-04	4	80	2	IPR013312
Domain	5peptide_repeat	SV2B SV2C	1.08e-04	4	80	2	IPR001646
Domain	PAN_AP	MST1 MST1L	1.80e-04	5	80	2	SM00473
Domain	PAN	MST1 MST1L	3.75e-04	7	80	2	PS50948
Domain	Pan_app	MST1 MST1L	3.75e-04	7	80	2	IPR003609
Domain	TLV_coat	ERVV-2 ERVV-1	3.75e-04	7	80	2	PF00429
Domain	PAN_1	MST1 MST1L	3.75e-04	7	80	2	PF00024
Domain	TLV/ENV_coat_polyprotein	ERVV-2 ERVV-1	4.99e-04	8	80	2	IPR018154
Domain	CN_hydrolase	BTD NIT1	4.99e-04	8	80	2	PF00795
Domain	-	BTD NIT1	4.99e-04	8	80	2	3.60.110.10
Domain	CN_HYDROLASE	BTD NIT1	4.99e-04	8	80	2	PS50263
Domain	C-N_Hydrolase	BTD NIT1	4.99e-04	8	80	2	IPR003010
Domain	MAC_perforin	BRINP3 BRINP2	7.97e-04	10	80	2	IPR001862
Domain	MACPF	BRINP3 BRINP2	9.72e-04	11	80	2	PF01823
Domain	TF_fork_head_CS_2	FOXA1 FOXF1 FOXF2	1.01e-03	46	80	3	IPR030456
Domain	TF_fork_head_CS_1	FOXA1 FOXF1 FOXF2	1.07e-03	47	80	3	IPR018122
Domain	MACPF	BRINP3 BRINP2	1.16e-03	12	80	2	SM00457
Domain	MACPF	BRINP3 BRINP2	1.16e-03	12	80	2	IPR020864
Domain	FH	FOXA1 FOXF1 FOXF2	1.21e-03	49	80	3	SM00339
Domain	FORK_HEAD_1	FOXA1 FOXF1 FOXF2	1.21e-03	49	80	3	PS00657
Domain	FORK_HEAD_2	FOXA1 FOXF1 FOXF2	1.21e-03	49	80	3	PS00658
Domain	Fork_head_dom	FOXA1 FOXF1 FOXF2	1.21e-03	49	80	3	IPR001766
Domain	FORK_HEAD_3	FOXA1 FOXF1 FOXF2	1.21e-03	49	80	3	PS50039
Domain	Forkhead	FOXA1 FOXF1 FOXF2	1.21e-03	49	80	3	PF00250
Domain	Spectrin_alpha_SH3	SH3GL2 SH3GL3	1.83e-03	15	80	2	IPR013315
Domain	BAR	SH3GL2 SH3GL3	1.83e-03	15	80	2	SM00721
Domain	BAR	SH3GL2 SH3GL3	1.83e-03	15	80	2	PF03114
Domain	BAR_dom	SH3GL2 SH3GL3	2.09e-03	16	80	2	IPR004148
Domain	Kringle	MST1 MST1L	2.36e-03	17	80	2	IPR000001
Domain	Kringle_CS	MST1 MST1L	2.36e-03	17	80	2	IPR018056
Domain	KRINGLE_2	MST1 MST1L	2.36e-03	17	80	2	PS50070
Domain	Kringle	MST1 MST1L	2.36e-03	17	80	2	PF00051
Domain	KRINGLE_1	MST1 MST1L	2.36e-03	17	80	2	PS00021
Domain	KR	MST1 MST1L	2.36e-03	17	80	2	SM00130
Domain	BAR	SH3GL2 SH3GL3	2.96e-03	19	80	2	PS51021
Domain	FA58C	CPXM1 F8	3.61e-03	21	80	2	SM00231
Domain	FA58C_3	CPXM1 F8	3.61e-03	21	80	2	PS50022
Domain	FA58C_1	CPXM1 F8	3.61e-03	21	80	2	PS01285
Domain	FA58C_2	CPXM1 F8	3.61e-03	21	80	2	PS01286
Domain	-	CPXM1 F8 FBXO2	3.79e-03	73	80	3	2.60.120.260
Domain	MFS_1	SV2B SV2C SLC17A6	4.41e-03	77	80	3	PF07690
Domain	MFS	SV2B SV2C SLC17A6	4.41e-03	77	80	3	IPR011701
Domain	F5_F8_type_C	CPXM1 F8	4.70e-03	24	80	2	PF00754
Domain	FA58C	CPXM1 F8	4.70e-03	24	80	2	IPR000421
Domain	Collagen	COL4A4 COL17A1 MFRP	5.81e-03	85	80	3	IPR008160
Domain	Collagen	COL4A4 COL17A1 MFRP	5.81e-03	85	80	3	PF01391
Domain	-	SH3GL2 SH3GL3	7.29e-03	30	80	2	1.20.1270.60
Domain	AH/BAR-dom	SH3GL2 SH3GL3	7.29e-03	30	80	2	IPR027267
Domain	Galactose-bd-like	CPXM1 F8 FBXO2	7.67e-03	94	80	3	IPR008979
Domain	Sugar_transporter_CS	SV2B SV2C	8.27e-03	32	80	2	IPR005829
Domain	Kringle-like	MST1 MST1L	8.27e-03	32	80	2	IPR013806
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	FFAR3 GPR42 SLC17A6	6.76e-07	8	81	3	34626852
Pubmed	Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage.	SV2B SV2C SYNPR SLC17A6	4.51e-06	47	81	4	31235642
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	5.36e-06	2	81	2	25637492
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	5.36e-06	2	81	2	30478340
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	5.36e-06	2	81	2	38040866
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	5.36e-06	2	81	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	5.36e-06	2	81	2	26091414
Pubmed	Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.	MST1 MST1L	5.36e-06	2	81	2	29760744
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	5.36e-06	2	81	2	27550964
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	5.36e-06	2	81	2	35858247
Pubmed	Differences in the embryonic expression patterns of mouse Foxf1 and -2 match their distinct mutant phenotypes.	FOXF1 FOXF2	5.36e-06	2	81	2	14745957
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	5.36e-06	2	81	2	22506074
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	5.36e-06	2	81	2	32073900
Pubmed	Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.	MST1 MST1L	5.36e-06	2	81	2	8393443
Pubmed	MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.	MST1 MST1L	5.36e-06	2	81	2	27609031
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	5.36e-06	2	81	2	24748202
Pubmed	Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.	MST1 MST1L	5.36e-06	2	81	2	24980820
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	5.36e-06	2	81	2	36362376
Pubmed	Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.	ERVV-2 ERVV-1	5.36e-06	2	81	2	18826608
Pubmed	Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.	MST1 MST1L	5.36e-06	2	81	2	31206688
Pubmed	LCCL peptide cleavage after noise exposure exacerbates hearing loss and is associated with the monocyte infiltration in the cochlea.	COCH LLGL1	5.36e-06	2	81	2	34735822
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	5.36e-06	2	81	2	20399779
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	5.36e-06	2	81	2	19630535
Pubmed	Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders.	BRINP3 BRINP2	5.36e-06	2	81	2	27826231
Pubmed	Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.	MST1 MST1L	5.36e-06	2	81	2	10728827
Pubmed	Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.	MST1 MST1L	5.36e-06	2	81	2	16961763
Pubmed	Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.	MST1 MST1L	5.36e-06	2	81	2	39253972
Pubmed	Forkhead transcription factor FoxF2 is expressed in mesodermal tissues involved in epithelio-mesenchymal interactions.	FOXF1 FOXF2	5.36e-06	2	81	2	10822266
Pubmed	Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.	MST1 MST1L	5.36e-06	2	81	2	32017081
Pubmed	Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.	MST1 MST1L	5.36e-06	2	81	2	30708325
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	5.36e-06	2	81	2	23110765
Pubmed	Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.	MST1 MST1L	5.36e-06	2	81	2	24409221
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	5.36e-06	2	81	2	26522986
Pubmed	Gastroparesis is associated with decreased FOXF1 and FOXF2 in humans, and loss of FOXF1 and FOXF2 results in gastroparesis in mice.	FOXF1 FOXF2	5.36e-06	2	81	2	30565344
Pubmed	Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.	MST1 MST1L	5.36e-06	2	81	2	27696525
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	5.36e-06	2	81	2	14722361
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	5.36e-06	2	81	2	27664183
Pubmed	Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.	MST1 MST1L	5.36e-06	2	81	2	8340069
Pubmed	Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.	MST1 MST1L	5.36e-06	2	81	2	9486989
Pubmed	Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.	MST1 MST1L	5.36e-06	2	81	2	33887258
Pubmed	Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.	ERVV-2 ERVV-1	5.36e-06	2	81	2	23555306
Pubmed	HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.	MST1 MST1L	5.36e-06	2	81	2	25938541
Pubmed	DmFoxF, a novel Drosophila fork head factor expressed in visceral mesoderm.	FOXF1 FOXF2	5.36e-06	2	81	2	11804790
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	5.36e-06	2	81	2	26260360
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	5.36e-06	2	81	2	37019194
Pubmed	Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2.	FOXF1 FOXF2	5.36e-06	2	81	2	8626802
Pubmed	Microbiota modulate sympathetic neurons via a gut-brain circuit.	FFAR3 GPR42 SLC17A6	5.43e-06	15	81	3	32641826
Pubmed	Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells.	BRINP3 BRINP2	1.60e-05	3	81	2	20025061
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	1.60e-05	3	81	2	22673524
Pubmed	Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance.	SH3GL2 SH3GL3	1.60e-05	3	81	2	15919751
Pubmed	The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.	MST1 MST1L	1.60e-05	3	81	2	10225971
Pubmed	NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation.	UBE2D1 FOXA1	1.60e-05	3	81	2	33530829
Pubmed	Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family.	BRINP3 BRINP2	1.60e-05	3	81	2	15193423
Pubmed	Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis.	SV2B SV2C	1.60e-05	3	81	2	23617838
Pubmed	Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.	MST1 MST1L	1.60e-05	3	81	2	38430683
Pubmed	Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.	MST1 MST1L	1.60e-05	3	81	2	12538524
Pubmed	Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.	MST1 MST1L	1.60e-05	3	81	2	19339990
Pubmed	TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.	MST1 MST1L	1.60e-05	3	81	2	26698664
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	1.60e-05	3	81	2	12496283
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	1.60e-05	3	81	2	23665276
Pubmed	Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.	MST1 MST1L	1.60e-05	3	81	2	30063115
Pubmed	Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.	MST1 MST1L	1.60e-05	3	81	2	27218122
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	1.60e-05	3	81	2	34210970
Pubmed	Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.	MST1 MST1L	1.60e-05	3	81	2	17395874
Pubmed	Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.	MST1 MST1L	1.60e-05	3	81	2	24852423
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	1.60e-05	3	81	2	31719611
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	1.60e-05	3	81	2	16123168
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	1.60e-05	3	81	2	22493486
Pubmed	Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.	MST1 MST1L	1.60e-05	3	81	2	27496379
Pubmed	Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.	MST1 MST1L	1.60e-05	3	81	2	12804176
Pubmed	Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.	MST1 MST1L	1.60e-05	3	81	2	12606483
Pubmed	No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.	SV2B SV2C	1.60e-05	3	81	2	18977120
Pubmed	Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.	MST1 MST1L	1.60e-05	3	81	2	36623453
Pubmed	Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.	MST1 MST1L	1.60e-05	3	81	2	37184367
Pubmed	CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.	MST1 MST1L	1.60e-05	3	81	2	38288506
Pubmed	The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.	MST1 MST1L	1.60e-05	3	81	2	8545120
Pubmed	Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.	MST1 MST1L	1.60e-05	3	81	2	25049204
Pubmed	Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.	SH3GL2 SH3GL3	1.60e-05	3	81	2	10535961
Pubmed	SV2 is the protein receptor for botulinum neurotoxin A.	SV2B SV2C	1.60e-05	3	81	2	16543415
Pubmed	Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.	MST1 MST1L	1.60e-05	3	81	2	1832957
Pubmed	Differential distribution and developmental expression of synaptic vesicle protein 2 isoforms in the mouse retina.	SV2B SV2C	1.60e-05	3	81	2	12687700
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	1.60e-05	3	81	2	23066016
Pubmed	Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.	MST1 MST1L	1.60e-05	3	81	2	25183307
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	1.60e-05	3	81	2	25581519
Pubmed	Expression of SV2 isoforms during rodent brain development.	SV2B SV2C	1.60e-05	3	81	2	23937191
Pubmed	MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.	MST1 MST1L	1.60e-05	3	81	2	35525373
Pubmed	SV2 modulates the size of the readily releasable pool of secretory vesicles.	SV2B SV2C	1.60e-05	3	81	2	11483953
Pubmed	MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.	MST1 MST1L	1.60e-05	3	81	2	27510910
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	1.60e-05	3	81	2	22190648
Pubmed	Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.	MST1 MST1L	1.60e-05	3	81	2	31976559
Pubmed	Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice.	MST1 MST1L	1.60e-05	3	81	2	32468668
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	1.60e-05	3	81	2	31272808
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	1.60e-05	3	81	2	23885020
Pubmed	Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns.	SV2B SV2C	1.60e-05	3	81	2	33588752
Pubmed	Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.	MST1 MST1L	1.60e-05	3	81	2	29127009
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	1.60e-05	3	81	2	29768180
Pubmed	Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.	MST1 MST1L	1.60e-05	3	81	2	27465533
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	1.60e-05	3	81	2	18931303
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	1.60e-05	3	81	2	38524121
Pubmed	Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.	MST1 MST1L	1.60e-05	3	81	2	30771091
Cytoband	11p14.3	GAS2 SLC17A6	2.37e-04	13	81	2	11p14.3
GeneFamily	Forkhead boxes	FOXA1 FOXF1 FOXF2	1.45e-04	43	43	3	508
GeneFamily	N-BAR domain containing	SH3GL2 SH3GL3	3.59e-04	12	43	2	1289
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A4 FMO2 SH3GL2 SH3GL3 PKHD1 FBXO2	4.29e-07	157	81	6	9665a1375cfd8e9b8781c852686591226c0e0d9a
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	TBX15 FMO2 CPT1C KCNK17 FOXF1 FOXF2	7.57e-07	173	81	6	75e26a65071b0d2f30ed0b2aa9859c488f5cf362
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	TBX15 FMO2 CPT1C KCNK17 FOXF1 FOXF2	7.57e-07	173	81	6	26e2e674f5d312fa8f61c11b553dc6101f063b16
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	GLDC FFAR3 GPR42 SH3GL2 SH3GL3 TM4SF4	9.24e-07	179	81	6	06f92c884189197c86793191c05f65e34925c097
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBX15 COL4A4 FMO2 KCNK17 TNS1 FOXF2	1.08e-06	184	81	6	9f524f0a1e7eb50e3b97a35c0ea7e183a4e99aa8
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal-Mes\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBX15 COL4A4 FMO2 KCNK17 TNS1 FOXF2	1.08e-06	184	81	6	779016341dbd6d54b5fdb8711692d31a9b2cec4b
ToppCell	facs-Heart-RV-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 PTPRH PKHD1 TMEM178B PLA2G4D	1.10e-05	160	81	5	41d6c811c445c0ba9b6a2deb10a3b6b793172582
ToppCell	facs-Heart-RV-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 PTPRH PKHD1 TMEM178B PLA2G4D	1.10e-05	160	81	5	c1d03c0ac9c12615a06499209fcdf18e9b6f1fba
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO2 COCH GGT6 PKHD1 FOXA1	1.17e-05	162	81	5	3a1cbfed5a063131d49e3c1584f62b12660ecb36
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO2 COCH GGT6 PKHD1 FOXA1	1.17e-05	162	81	5	04b3c38bb27fa369a9ac5b60883f8b058abc5180
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf\|Thalamus / BrainAtlas - Mouse McCarroll V32	UBE2D1 COL17A1 GGT6 FFAR3	1.26e-05	78	81	4	5b45aacaff2a2b98c4ef8e7ac51ad482a69a1d8b
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Trf.Ctps_(Ctps)\|Thalamus / BrainAtlas - Mouse McCarroll V32	UBE2D1 COL17A1 GGT6 FFAR3	1.26e-05	78	81	4	afed2f358c8a33889931bc5ad8cb24f92323e6f8
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Nefm_(dSPN)-\|Striatum / BrainAtlas - Mouse McCarroll V32	COCH COL17A1 FFAR3 PKHD1	1.39e-05	80	81	4	cb60461818f0900964d2a14c7f8462e7f37b3dff
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Nefm_(dSPN)\|Striatum / BrainAtlas - Mouse McCarroll V32	COCH COL17A1 FFAR3 PKHD1	1.39e-05	80	81	4	27cc5ea77983fb0604545a0ff818eede8ba72b82
ToppCell	367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SH3GL2 TM4SF4 BRINP2 FBXO2 BCO1	1.60e-05	173	81	5	e05cddf5bf63cf419343ff229453327519765be8
ToppCell	367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|367C / Donor, Lineage, Cell class and subclass (all cells)	SH3GL2 TM4SF4 BRINP2 FBXO2 BCO1	1.60e-05	173	81	5	74ad5ed33821b8816c9c8e67c50ee4496ba18e2f
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	SV2B GAS2 TMEM178B PLA2G4D SLC17A6	1.70e-05	175	81	5	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	SV2B GAS2 TMEM178B PLA2G4D SLC17A6	1.70e-05	175	81	5	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A4 FMO2 SH3GL2 SH3GL3 PKHD1	1.79e-05	177	81	5	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)\|367C / Donor, Lineage, Cell class and subclass (all cells)	PNMT SV2C PTGIS F8 FOXF1	1.84e-05	178	81	5	e1e96a0e3ff718ebf676a982bc63e8ced6984059
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	PNMT SV2C PTGIS F8 FOXF1	1.84e-05	178	81	5	363e8b23b3834692a8a79e5fdc7b43bd3a4dab5e
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRYGA PTPRH SH3GL2 TM4SF4 SV2C	1.89e-05	179	81	5	d96741c5c551e36421b2ad938072ab7d506c3835
ToppCell	facs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPT1C NAV1 CPXM1 PTGIS FOXF1	1.94e-05	180	81	5	12537d8a569faa69f474284d2c201475722b8ca1
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A4 FMO2 PTGIS FBXO2 BCO1	1.99e-05	181	81	5	330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A4 FMO2 PTGIS FBXO2 BCO1	1.99e-05	181	81	5	3f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCell	RV\|World / Chamber and Cluster_Paper	GAS2 AIG1 NAV1 NCEH1 TMEM178B	1.99e-05	181	81	5	bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBE2D1 PTPRH SH3GL3 AIG1 FBXO2	2.05e-05	182	81	5	0beffe6b9b36cfd196ec98a18f6ded080c162f90
ToppCell	P28-Mesenchymal\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.05e-05	182	81	5	69f9d44694fe4f55a971ae0ac5dc3e7448ee78f3
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BRINP3 SV2B SH3GL2 SV2C SLC17A6	2.16e-05	184	81	5	6475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|tumor_Lung / Location, Cell class and cell subclass	MST1 SH3GL3 BRINP2 CPXM1 PTGIS	2.16e-05	184	81	5	b0a251030d127858e68cf164be158f209a4d720f
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PTPRH SV2B SV2C TMEM178B PLA2G4D	2.27e-05	186	81	5	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	droplet-Lung-immune-endo-depleted\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.45e-05	189	81	5	c3fb363bb0156ffb3367c200f548faebda64ab4a
ToppCell	droplet-Lung-immune-endo-depleted-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.45e-05	189	81	5	2a2953f6b1b7d070d739dcaf7285fce6e097d9e4
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.45e-05	189	81	5	324c81285c51f4f8bb1aef428b18fe2c549c2c11
ToppCell	droplet-Lung-3m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.45e-05	189	81	5	5a636e952da9b1fd26aa17f7b129054f2da322b5
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.45e-05	189	81	5	e76dc36a01d8ad7590b3acc4c46abfcb76857448
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|Fibroblasts / Location, Cell class and cell subclass	MST1 COL17A1 SH3GL3 BRINP2 FBXO2	2.52e-05	190	81	5	d82ab67735c1f365d4b0e02b5fa91c64cdc234da
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.52e-05	190	81	5	9cd147a174017ebda23cc47b6d4552d898acd092
ToppCell	droplet-Lung-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.52e-05	190	81	5	0b7200897b2c389632c9b1ee37e272b811555dbc
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.58e-05	191	81	5	a261f0738d974784bbdd60f23092bfbcca464459
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.58e-05	191	81	5	094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.58e-05	191	81	5	6594398cc8151c73696391a43ac110c10283dab1
ToppCell	facs-Lung-24m-Mesenchymal\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FMO2 CPXM1 TNS1 PTGIS FOXF2	2.58e-05	191	81	5	ba02cbdfda6a94374a6472eb88499059979af472
ToppCell	ILEUM-inflamed-(8)_Smooth_muscle_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ERVV-1 TNS1 PTGIS FOXF1 FOXF2	2.71e-05	193	81	5	084c88f08ce0ecd6c9f4334caed370eb2154f896
ToppCell	Endothelial-A-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	PNMT TMEM178B PTGIS F8 FOXF1	2.78e-05	194	81	5	abea887dd472c1a0d572e690bc8914c1b94712ad
ToppCell	Bronchial-NucSeq-Stromal-Mesofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBX15 MST1 PTPRH BRINP2 BCO1	2.92e-05	196	81	5	96e5c6d155273e82ebafa180df8bb589c3e3e54e
ToppCell	Bronchial-NucSeq-Stromal-Mesofibroblastic-Mesothelia\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBX15 MST1 PTPRH BRINP2 BCO1	2.92e-05	196	81	5	ce13af36fc2932e8125013041742593ff3d07e86
ToppCell	distal-Epithelial-Goblet\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL17A1 PTPRH GGT6 G6PC2 BCO1	2.99e-05	197	81	5	da1ed7303cc9cb2d205c0e5c49c52544d3540951
ToppCell	ASK452-Epithelial-Type_1\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	COL4A4 FMO2 SH3GL3 NCEH1 TNS1	2.99e-05	197	81	5	dc0a6dca4af6b216357b06f67203274f8b2a8bb0
ToppCell	distal-3-Epithelial-Goblet\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL17A1 PTPRH GGT6 G6PC2 BCO1	2.99e-05	197	81	5	a00784ccfb1de6a96b91e2a8a2889b69f31a33da
ToppCell	Bronchial-10x5prime-Stromal-Mesofibroblastic-Mesothelia\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MST1 PTPRH BRINP2 CPXM1 PTGIS	2.99e-05	197	81	5	26888af95a7cc082a1f1218af35b1f07cb9436ed
ToppCell	Bronchial-10x5prime-Stromal-Mesofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MST1 PTPRH BRINP2 CPXM1 PTGIS	2.99e-05	197	81	5	438de7f0d35d81d5f5e41dcef7b2c54b6da03df4
ToppCell	distal-Epithelial-Goblet-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL17A1 PTPRH GGT6 G6PC2 BCO1	2.99e-05	197	81	5	3fbf456ae4f73da4f6254a6f0d24f0ec27d7a3cc
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	COL4A4 FMO2 SH3GL2 SH3GL3 PKHD1	3.07e-05	198	81	5	1282db321e27499d310339d6383974614e295a20
ToppCell	ASK452-Epithelial-Type_1\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	COL4A4 FMO2 SH3GL3 NCEH1 TNS1	3.14e-05	199	81	5	48cafe44951908d03f3c6f3e185e9cbb86fb5b3b
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	LLGL1 TTLL5 FOXA1 ABHD16A	1.08e-04	135	81	4	c4d3c9eba2a85ac40fea5ecfcc2b442a472323d0
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CWH43 PTPRH SV2B SH3GL2	1.62e-04	150	81	4	9d5bbdca19da60e1a2121ef64ec8e1375a5dbf6d
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CWH43 PTPRH SV2B SH3GL2	1.75e-04	153	81	4	b37a1ecad389d2848b8ca4d287823e8048207420
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Sc17a7.Crym_(Subiculum)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	COL17A1 PLA2G4D FOXA1	1.88e-04	61	81	3	3d834421698c01e426fbbc22f5eebc91fa7fefde
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Sc17a7.Crym_(Subiculum)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	COL17A1 PLA2G4D FOXA1	1.88e-04	61	81	3	fb5bb9174907ec1916c4ace284d54317d925fec5
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Sc17a7.Crym_(Subiculum)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	COL17A1 PLA2G4D FOXA1	1.88e-04	61	81	3	db05e7997d8e25700a0e1ea359d36161c4e78bc9
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PTPRH SV2B SV2C GTSCR1	2.02e-04	159	81	4	7747cef94c55144fddcd024a7495318357f1351b
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RAPGEF2 KCNK17 CCIN FOXF1	2.07e-04	160	81	4	636127753e3a22831f39d4c8170df40901e4329d
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RAPGEF2 KCNK17 CCIN FOXF1	2.07e-04	160	81	4	cb8d0dc1a6c69c7a85c5fdd8f0f6cca1b73dfc63
ToppCell	COVID-19-kidney-Epithelial_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	SV2B NAV1 F8 CCIN	2.07e-04	160	81	4	0d4880f85565d8c540c94a8f8109147b3029279a
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A4 FMO2 SH3GL3 PKHD1	2.12e-04	161	81	4	1e17a993126e1f2a25ee7dfbb95a74ccb2a26791
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MST1 DEAF1 SH3GL3 NCEH1	2.22e-04	163	81	4	360cd65decda24853124f33a174f5224d7f3ce23
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MST1 DEAF1 SH3GL3 NCEH1	2.22e-04	163	81	4	b59d9b4f7c9f4e5e2c7783a49a96729dae3a81e5
ToppCell	15-Airway-Mesenchymal-Airway_Smooth_Muscle\|Airway / Age, Tissue, Lineage and Cell class	BRINP3 PNMT KCNK17 FOXF1	2.33e-04	165	81	4	531804467601e1ee1f771cffa21501f6d464ae10
ToppCell	facs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COCH SH3GL3 F8 CCIN	2.44e-04	167	81	4	a4a795751644b22af616335379e64ae95175180c
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Microfold_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BRINP3 SV2C NCEH1 FOXA1	2.55e-04	169	81	4	a54a8494c1feff29d77ab4737fcfabc84ace5c94
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SV2B CPT1C TM4SF4 TMEM178B	2.55e-04	169	81	4	96a2aec9acf8a6f966973c035e5ade456cf47772
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCAF2 FFAR3 G6PC2 F8	2.55e-04	169	81	4	87116c33c5ca8cb1862e103e5607b1df4d264569
ToppCell	356C-Epithelial_cells-Epithelial-E_(AT2)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL4A4 FMO2 COL17A1 SH3GL2	2.61e-04	170	81	4	4cd3b7e43a061948084c01713ae141b5c2c07d89
ToppCell	356C-Epithelial_cells-Epithelial-E_(AT2)\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL4A4 FMO2 COL17A1 SH3GL2	2.61e-04	170	81	4	36c9f7f98612a72dc511c8da4358d67444f6bcf4
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL4A4 PTGIS SYNPR FBXO2	2.73e-04	172	81	4	9a256db817c1af1802203cc88a55d608fb328c63
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A4 CPXM1 PTGIS FBXO2	2.79e-04	173	81	4	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A4 CPXM1 PTGIS FBXO2	2.79e-04	173	81	4	3725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SH3GL2 TM4SF4 SV2C FOXA1	2.85e-04	174	81	4	a62531ebf16b32b249168dca11b870f63a8aa81c
ToppCell	facs-Marrow-T-cells-24m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BTD BRINP2 TMEM178B FBXO2	2.91e-04	175	81	4	0a01e0104cfa3091bc05b0f1d087c941688169a5
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	BRINP3 KCNK17 CCIN FOXF1	2.98e-04	176	81	4	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SH3GL2 TM4SF4 FOXA1 SYNPR	2.98e-04	176	81	4	fb718a6b07aa5d56600263280afa530bcb63db42
ToppCell	normal_Lung-Fibroblasts-Mesothelial_cells\|normal_Lung / Location, Cell class and cell subclass	MST1 COL17A1 CPXM1 FBXO2	2.98e-04	176	81	4	f31d7234053085a82cf9d55aeedd1e04d34789c3
ToppCell	356C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|356C / Donor, Lineage, Cell class and subclass (all cells)	TBX15 BRINP3 KCNK17 FOXF2	2.98e-04	176	81	4	135d51d28a7ad2a67d5a6c49eb6e661f4beb66f5
ToppCell	356C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	TBX15 BRINP3 KCNK17 FOXF2	2.98e-04	176	81	4	2287bd8382f41e36ebb0875a0133bada1ec81fa7
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TBX15 PNMT NAV1 F8	2.98e-04	176	81	4	64e426f5e84884ce2c29acf6f4b958962a63927f
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	BRINP3 KCNK17 CCIN FOXF1	2.98e-04	176	81	4	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	Control-Epithelial_alveolar-AT_1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A4 FMO2 SH3GL3 PKHD1	3.11e-04	178	81	4	aa7d43c655df493f1330a5001efaa484e4a19f69
ToppCell	Control-Epithelial_alveolar-AT_1-AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A4 FMO2 SH3GL3 PKHD1	3.11e-04	178	81	4	1817bc520f3d23da8c0fa09bba50ae703a820cb1
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-Mast_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PNMT FFAR3 GPR42 KCNK17	3.11e-04	178	81	4	c6704fcd21a9d2fe45679a1d998f04213b3bf224
ToppCell	droplet-Fat-Scat-21m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRINP3 CWH43 COL17A1 BCO1	3.11e-04	178	81	4	5fc9f41609735b972a2cd0830182d13742cd5bf5
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SV2B GAS2 SV2C SLC17A6	3.11e-04	178	81	4	674ee5095b98929c29e4f6bd56029a336cc4a38c
ToppCell	COVID-19_Mild-Hematopoietic_SC-HSPC\|COVID-19_Mild / Disease group, lineage and cell class	PNMT SH3GL3 CPXM1 KCNK17	3.17e-04	179	81	4	19fcf48f5e02e4cb2b328efb4502f337e1282f72
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SH3GL2 TM4SF4 SV2C TMEM178B	3.17e-04	179	81	4	228d12ed1c8dc92aefbcea4aaf7d108783c22be0
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A4 FMO2 SH3GL2 SH3GL3	3.17e-04	179	81	4	4f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCell	metastatic_Brain-Endothelial_cells-Lymphatic_ECs\|metastatic_Brain / Location, Cell class and cell subclass	FMO2 LLGL1 F8 FOXF2	3.17e-04	179	81	4	56fe381ffbaba3a4f2f587a3e367b0d11fbd4a2a
ToppCell	COVID-19_Mild-Hematopoietic_SC\|COVID-19_Mild / Disease group, lineage and cell class	PNMT SH3GL3 CPXM1 KCNK17	3.17e-04	179	81	4	50a073166e34bcfa52a62c4dafb3aef724e0fa8e
ToppCell	LA-01._Fibroblast_I\|LA / Chamber and Cluster_Paper	COL4A4 FMO2 NAV1 PTGIS	3.17e-04	179	81	4	dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SH3GL2 TM4SF4 SV2C TMEM178B	3.17e-04	179	81	4	b8ca29aebd25ebac441bebd769bbf98c536d3166
ToppCell	LV\|World / Chamber and Cluster_Paper	GAS2 AIG1 NCEH1 TMEM178B	3.24e-04	180	81	4	5ac6f485a58bb29462fec02dfbe8eb70864eafe3
Disease	lung cancer (is_implicated_in)	ATR DVL3 FOXA1	8.64e-04	74	74	3	DOID:1324 (is_implicated_in)
Disease	body weight loss	TBX15 PKHD1	1.39e-03	22	74	2	EFO_0005245
Disease	inflammatory bowel disease (implicated_via_orthology)	MST1 MST1L	1.79e-03	25	74	2	DOID:0050589 (implicated_via_orthology)
Disease	response to paliperidone, schizophrenia symptom severity measurement	BRINP3 CWH43 SH3GL2 SLC17A6	2.15e-03	216	74	4	EFO_0007925, EFO_0007927

Protein segments in the cluster

Peptide	Gene	Start	Entry
TGWHSSGQRYLSDPM	SYNPR	201	Q8TBG9
WSSTLPAGSSMGTYH	COL17A1	221	Q9UMD9
FGGSHSESWFMPVNE	BRINP3	576	Q76B58
AIEMPSHQTYGGSWK	AIG1	26	Q9NVV5
IRDNFHYWASPEGSM	CCIN	156	Q13939
GNYAGHDWFVSSLFM	TBC1D32	1061	Q96NH3
IGGFTATWAAMSYPD	ABHD16A	356	O95870
WIGYSFLMHTGAGDQ	COL4A4	1596	P53420
ADWHTVPGSMNDFSY	CPXM1	566	Q96SM3
GKYPDYQHWMGLSDS	CRYGA	61	P11844
AAIGMIAPWGGFTYH	ERVV-2	331	B6SEH9
SVHLMEWSPDGEYFA	DMXL2	171	Q8TDJ6
WVSHTAAMTGTFPAY	DVL3	361	Q92997
LTPGHTAGHMSYFLW	HAGHL	106	Q6PII5
TAGHMSYFLWEDDCP	HAGHL	111	Q6PII5
PTMWAGTNSGSVFAY	LLGL1	741	Q15334
HGSSEGVFWMEYGDF	CAPN15	766	O75808
VEGFGFHAWYQAMAP	MFRP	241	Q9BY79
YPEWNPDNDTGHTMG	MATR3	326	P43243
GPLMDCWAFHYNVSS	MST1L	66	Q2TV78
GSHYTSPSENMWNTG	CARM1	486	Q86X55
AAIGMIAPWGGFTYH	ERVV-1	331	B6SEH8
DGGGWMEISHTFTDY	FBXO2	246	Q9UK22
PPLLFSHMEGWSYTE	KCNK17	196	Q96T54
GFHGCMIFTSWPTNF	NCEH1	376	Q6PIU2
FMYPASPWSHISAGA	PRKD2	766	Q9BZL6
AVERLWDYGMSSSPH	F8	1721	P00451
MDTGPDQSYFSGNHW	GPR42	1	O15529
QWYPHDTGMFTSSSF	ERCC8	106	Q13216
MQSDIYHPGHSFPSW	GTSCR1	1	Q86UQ5
GSYWTLHPDSGNMFE	FOXA1	241	P55317
SYHGWLLEPHGAMSS	CPT1C	131	Q8TCG5
FPGHWAYIAGFDDMV	ATR	2286	Q13535
GENWYSPTEFEAMAG	DEAF1	231	O75398
ETSFPYSMGWHGAPT	GALT	291	P07902
LGAMFWGLFHDSSSG	GGT6	146	Q6P531
MDTGPDQSYFSGNHW	FFAR3	1	O14843
SGIHTPLESFWYHDM	BTD	311	P43251
SPSGHAMGASCVWYV	G6PC2	111	Q9NQR9
SGPYGFHEMQELWTK	DNAJC13	986	O75165
ATGGWVMPDEANSHY	MAN2A2	246	P49641
HGTWVMSRISEDGYP	FMO2	216	Q99518
NPDGDSHGPWCYTMD	MST1	421	P26927
NGFFSYHMPNWFGTT	COCH	326	O43405
GQWVLMYFGFTHCPD	SCO2	121	O43819
RASYGHSMVVDPWGT	NIT1	266	Q86X76
SGSTWTMAHLYGDPE	PLA2G4D	361	Q86XP0
GHYWTIDPASEFMFE	FOXF2	171	Q12947
SCRSEGTPAWYMHGE	NAV1	336	Q8NEY1
NVGAWGDYDHSAFME	POTED	116	Q86YR6
TDFGPSTRYHTWGIM	CWH43	491	Q9H720
SGPGLSDMHQYSQWL	GAS2	11	O43903
VMEPHAVYSGSAAAW	FOXF1	256	Q12946
PWSYMAHTGFESALN	RUNDC1	571	Q96C34
FGMTTTAIYPWGHSF	TAS2R10	261	Q9NYW0
PDDISHGYGWSMFCA	TMEM178B	241	H3BS89
IPHYGWSFSMGSAYQ	SV2C	301	Q496J9
NWYEGMIHGESGFFP	SH3GL3	321	Q99963
SIIPHYGWGFSMGTN	SV2B	256	Q7L1I2
ADVQISAGWMHSGYP	TCAF2	716	A6NFQ2
GSGWHEMGLLDFSYS	PTGIS	156	Q16647
VYIHPDSLASGDTWM	TBX15	196	Q96SF7
DHWAESMFPSFSGLF	PKHD1	1851	P08F94
FSGAWNEMVTHPGYY	TBC1D9B	521	Q66K14
NPFGGSHSESWFMPV	BRINP2	591	Q9C0B6
GPGMHTVGESRYNHW	BCO1	36	Q9HAY6
WGGSSGHDAPMIAYD	ADPRH	266	P54922
EEPGAFNWSMYSQHA	PNMT	116	P11086
YSGDPAGLWASSSHM	RAPGEF2	1281	Q9Y4G8
PETVGMIHGSFFWGY	SLC17A6	121	Q9P2U8
NWYEGMLHGHSGFFP	SH3GL2	326	Q99962
WDSYDNFSGHRDDGM	TNS1	336	Q9HBL0
SMIGPHGYISASDWP	TMEM87B	201	Q96K49
FWGTPMSEERSHKSY	TMTC3	56	Q6ZXV5
EHRFGPSDAMAWAYT	TSNAXIP1	426	Q2TAA8
GSDYINASFMPGLWS	PTPRH	871	Q9HD43
MHDGNQYSACTEPWT	TRIM62	391	Q9BVG3
LMANSTWGYPFHDGD	TM4SF4	121	P48230
PSSTDYNLMWTGSHL	TTLL5	91	Q6EMB2
SSPGLQLWTHYDVMD	TYW5	151	A2RUC4
FHWQATIMGPPDSAY	UBE2D1	31	P51668
QDYGFHAPTMSWPVA	GLDC	886	P23378