Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H2BS36 kinase activity

PRKAA1 PRKAA2

1.88e-052872GO:0140823
GeneOntologyMolecularFunction[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity

PRKAA1 PRKAA2

1.88e-052872GO:0047322
GeneOntologyMolecularFunctionhistone H2B kinase activity

PRKAA1 PRKAA2

1.88e-052872GO:0140998
GeneOntologyMolecularFunctionsodium channel activity

TRPM5 SCN7A GRIK1 GRIK2

7.76e-0552874GO:0005272
GeneOntologyMolecularFunctionkainate selective glutamate receptor activity

GRIK1 GRIK2

2.78e-046872GO:0015277
GeneOntologyMolecularFunctionprotein kinase activity

CDKL5 MAP2K4 TAOK3 GUCY2D ROR2 PRKAA1 PRKAA2 FER FGFR4 TEC

2.79e-046008710GO:0004672
GeneOntologyMolecularFunctionextracellularly glutamate-gated ion channel activity

GRIK1 GRIK2

3.89e-047872GO:0005234
GeneOntologyMolecularFunctiontranslation termination factor activity

GSPT2 GSPT1

3.89e-047872GO:0008079
GeneOntologyMolecularFunctiontranslation release factor activity

GSPT2 GSPT1

3.89e-047872GO:0003747
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

MAP2K4 ROR2 FER FGFR4 TEC

4.32e-04145875GO:0004713
GeneOntologyMolecularFunctionAMP-activated protein kinase activity

PRKAA1 PRKAA2

8.26e-0410872GO:0004679
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

PRDM9 SMYD3

8.26e-0410872GO:0140999
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

TRPM5 SCN7A SLC6A15 GRIK1 GRIK2

9.11e-04171875GO:0015081
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

CDKL5 MAP2K4 TAOK3 GUCY2D ROR2 PRKAA1 PRKAA2 FER FGFR4 TEC

1.02e-037098710GO:0016773
GeneOntologyMolecularFunctionhistone H3K36 methyltransferase activity

PRDM9 SMYD3

1.42e-0313872GO:0046975
GeneOntologyMolecularFunctiontranslation regulator activity, nucleic acid binding

EFL1 GSPT2 CELF1 GSPT1

1.46e-03112874GO:0090079
GeneOntologyMolecularFunctionkinase activity

CDKL5 MAP2K4 TAOK3 GUCY2D ROR2 PRKAA1 PRKAA2 FER FGFR4 TEC

1.78e-037648710GO:0016301
GeneOntologyBiologicalProcesspositive regulation of peptidyl-lysine acetylation

DIP2B PRKAA1 PRKAA2

2.59e-067883GO:2000758
GeneOntologyBiologicalProcessregulation of peptidyl-lysine acetylation

DIP2B PRKAA1 PRKAA2

1.61e-0512883GO:2000756
GeneOntologyBiologicalProcessnegative regulation of synaptic transmission, glutamatergic

MYO5A GRIK1 GRIK2

2.08e-0513883GO:0051967
GeneOntologyBiologicalProcesscellular response to prostaglandin E stimulus

PRKAA1 PRKAA2 ADCY6

4.04e-0516883GO:0071380
GeneOntologyBiologicalProcesspositive regulation of protein acetylation

DIP2B PRKAA1 PRKAA2

5.85e-0518883GO:1901985
GeneOntologyBiologicalProcessprotein localization to lipid droplet

PRKAA1 PRKAA2

1.07e-044882GO:1990044
GeneOntologyBiologicalProcessmonocarboxylic acid biosynthetic process

MYO5A PRKAA1 PRKAA2 ABCB11 ACSBG2 FGFR4 HTT

1.24e-04260887GO:0072330
GeneOntologyBiologicalProcesscellular response to prostaglandin stimulus

PRKAA1 PRKAA2 ADCY6

1.25e-0423883GO:0071379
GeneOntologyBiologicalProcessresponse to prostaglandin E

PRKAA1 PRKAA2 ADCY6

1.82e-0426883GO:0034695
GeneOntologyBiologicalProcessorganic hydroxy compound biosynthetic process

MYO5A INHBA PRKAA1 PRKAA2 ABCB11 FGFR4 HTT

1.83e-04277887GO:1901617
GeneOntologyBiologicalProcessregulation of protein acetylation

DIP2B PRKAA1 PRKAA2

2.28e-0428883GO:1901983
GeneOntologyBiologicalProcesspeptidyl-lysine acetylation

DIP2B PRKAA1 PRKAA2

2.28e-0428883GO:0018394
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

CDKL5 DIP2B NOX1 TBC1D22A ROR2 FER DNM3 LRRC4C INPP5F PREX1 ADCY6 HTT

2.45e-048468812GO:0120035
GeneOntologyBiologicalProcesspositive regulation of glycolytic process

ESRRB PRKAA1 PRKAA2

2.53e-0429883GO:0045821
GeneOntologyBiologicalProcesspositive regulation of nucleotide catabolic process

ESRRB PRKAA1 PRKAA2

2.53e-0429883GO:0030813
GeneOntologyBiologicalProcesspositive regulation of purine nucleotide catabolic process

ESRRB PRKAA1 PRKAA2

2.53e-0429883GO:0033123
GeneOntologyBiologicalProcessregulation of bile acid secretion

PRKAA1 ABCB11

2.67e-046882GO:0120188
GeneOntologyBiologicalProcessregulation of cell projection organization

CDKL5 DIP2B NOX1 TBC1D22A ROR2 FER DNM3 LRRC4C INPP5F PREX1 ADCY6 HTT

2.94e-048638812GO:0031344
GeneOntologyBiologicalProcesslipid droplet disassembly

PRKAA1 PRKAA2

3.73e-047882GO:1905691
GeneOntologyBiologicalProcessregulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

MYO5A HTT

3.73e-047882GO:0031585
GeneOntologyBiologicalProcessnegative regulation of tubulin deacetylation

PRKAA1 PRKAA2

3.73e-047882GO:1904428
GeneOntologyCellularComponentdendrite

CDKL5 DIP2B MAP2K4 TRPM5 MYO5A ROR2 PRKAA1 PRKAA2 NTSR2 DNM3 GRIK1 GRIK2 INPP5F PREX1 HTT RHEB

4.35e-078588716GO:0030425
GeneOntologyCellularComponentdendritic tree

CDKL5 DIP2B MAP2K4 TRPM5 MYO5A ROR2 PRKAA1 PRKAA2 NTSR2 DNM3 GRIK1 GRIK2 INPP5F PREX1 HTT RHEB

4.49e-078608716GO:0097447
GeneOntologyCellularComponentaxon

SLC12A6 CDKL5 DIP2B CNTNAP3B MAP2K4 MYO5A PRKAA1 PRKAA2 CNTNAP3 DNM3 GRIK1 GRIK2 INPP5F AP3B1 PREX1 HTT

7.18e-078918716GO:0030424
GeneOntologyCellularComponentneuronal cell body

DIP2B CNTNAP3B MAP2K4 TRPM5 MYO5A ROR2 PRKAA1 PRKAA2 CNTNAP3 NTSR2 GRIK1 GRIK2 INPP5F HTT RHEB

1.67e-068358715GO:0043025
GeneOntologyCellularComponentsomatodendritic compartment

CDKL5 DIP2B CNTNAP3B MAP2K4 TRPM5 MYO5A ROR2 PRKAA1 PRKAA2 CNTNAP3 NTSR2 DNM3 GRIK1 GRIK2 INPP5F PREX1 HTT RHEB

2.46e-0612288718GO:0036477
GeneOntologyCellularComponentcell body

DIP2B CNTNAP3B MAP2K4 TRPM5 MYO5A ROR2 PRKAA1 PRKAA2 CNTNAP3 NTSR2 GRIK1 GRIK2 INPP5F HTT RHEB

6.12e-069298715GO:0044297
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

CDKL5 MAP2K4 TTLL3 CFAP221 TOGARAM1 GRIK2 AP3B1 HTT TULP3

6.88e-06317879GO:0032838
GeneOntologyCellularComponentcytoplasmic region

CDKL5 MAP2K4 TTLL3 CFAP221 TOGARAM1 GRIK2 AP3B1 HTT TULP3

1.90e-05360879GO:0099568
GeneOntologyCellularComponenttranslation release factor complex

GSPT2 GSPT1

5.12e-053872GO:0018444
GeneOntologyCellularComponentneuron projection cytoplasm

CDKL5 MAP2K4 GRIK2 AP3B1 HTT

9.65e-05110875GO:0120111
GeneOntologyCellularComponentglutamatergic synapse

CDKL5 PPP2R1B CNNM2 MYO5A ROR2 DNM3 CC2D1A GRIK1 GRIK2 LRRC4C HTT RHEB

1.41e-048178712GO:0098978
GeneOntologyCellularComponentsodium channel complex

SCN7A GRIK1 GRIK2

2.35e-0429873GO:0034706
GeneOntologyCellularComponentkainate selective glutamate receptor complex

GRIK1 GRIK2

2.54e-046872GO:0032983
GeneOntologyCellularComponentperikaryon

DIP2B CNTNAP3B MAP2K4 CNTNAP3 NTSR2 GRIK2

3.39e-04223876GO:0043204
GeneOntologyCellularComponentdendrite cytoplasm

CDKL5 MAP2K4 GRIK2

5.71e-0439873GO:0032839
GeneOntologyCellularComponentnucleotide-activated protein kinase complex

PRKAA1 PRKAA2

9.19e-0411872GO:0031588
DomainAMPK_C

PRKAA1 PRKAA2

2.25e-052892IPR032270
DomainAdenylateSensor

PRKAA1 PRKAA2

2.25e-052892PF16579
DomainG_TR_1

EFL1 GSPT2 GSPT1

2.89e-0513893PS00301
DomainP-loop_NTPase

NDST3 EFL1 GSPT2 MYO5A SMC3 SHPRH ABCD4 DNM3 ABCB11 IFI44L SNRNP200 GSPT1 RHEB NLRP13

4.55e-058488914IPR027417
Domain-

NDST3 EFL1 GSPT2 SMC3 SHPRH ABCD4 DNM3 ABCB11 IFI44L SNRNP200 GSPT1 RHEB NLRP13

5.06e-0574689133.40.50.300
DomainKinase-like_dom

CDKL5 MAP2K4 TAOK3 GUCY2D ROR2 PRKAA1 PRKAA2 FER DNM3 FGFR4 TEC

5.24e-055428911IPR011009
DomainEFTu-like_2

EFL1 GSPT2 GSPT1

8.10e-0518893IPR004161
DomainGTP_EFTU_D2

EFL1 GSPT2 GSPT1

8.10e-0518893PF03144
DomainG_TR_2

EFL1 GSPT2 GSPT1

8.10e-0518893PS51722
DomainTF_GTP-bd_dom

EFL1 GSPT2 GSPT1

9.59e-0519893IPR000795
DomainProt_kinase_dom

CDKL5 MAP2K4 TAOK3 GUCY2D ROR2 PRKAA1 PRKAA2 FER FGFR4 TEC

1.10e-044898910IPR000719
DomainPROTEIN_KINASE_DOM

CDKL5 MAP2K4 TAOK3 GUCY2D ROR2 PRKAA1 PRKAA2 FER FGFR4 TEC

1.18e-044938910PS50011
DomainHEAT

IPO5 PPP2R1B TOGARAM1 HTT

1.68e-0458894IPR000357
DomainTransl_B-barrel

EFL1 GSPT2 GSPT1

2.82e-0427893IPR009000
DomainPROTEIN_KINASE_ATP

CDKL5 MAP2K4 TAOK3 ROR2 PRKAA1 PRKAA2 FER FGFR4 TEC

3.38e-04459899PS00107
DomainHEAT_REPEAT

IPO5 PPP2R1B TOGARAM1 HTT

3.47e-0470894PS50077
DomainPkinase_Tyr

GUCY2D ROR2 FER FGFR4 TEC

3.80e-04129895PF07714
DomainProtein_kinase_ATP_BS

CDKL5 MAP2K4 TAOK3 PRKAA1 PRKAA2 FER FGFR4 TEC

4.51e-04379898IPR017441
DomainKA1/Ssp2_C

PRKAA1 PRKAA2

4.64e-047892IPR028375
DomainSer-Thr/Tyr_kinase_cat_dom

GUCY2D ROR2 FER FGFR4 TEC

5.17e-04138895IPR001245
DomainTransl_elong_EFTu/EF1A_C

GSPT2 GSPT1

6.17e-048892IPR004160
DomainGTP_EFTU_D3

GSPT2 GSPT1

6.17e-048892PF03143
DomainANF_lig-bd_rcpt

GUCY2D GRIK1 GRIK2

7.23e-0437893IPR001828
DomainANF_receptor

GUCY2D GRIK1 GRIK2

7.23e-0437893PF01094
DomainG_TR_CS

GSPT2 GSPT1

7.91e-049892IPR031157
DomainTyrKc

ROR2 FER FGFR4 TEC

8.28e-0488894SM00219
DomainTyr_kinase_cat_dom

ROR2 FER FGFR4 TEC

8.28e-0488894IPR020635
DomainPeripla_BP_I

GUCY2D GRIK1 GRIK2

8.44e-0439893IPR028082
DomainTransl_elong_EF1A/Init_IF2_C

GSPT2 GSPT1

9.86e-0410892IPR009001
DomainPROTEIN_KINASE_TYR

ROR2 FER FGFR4 TEC

1.19e-0397894PS00109
DomainTyr_kinase_AS

ROR2 FER FGFR4 TEC

1.19e-0397894IPR008266
DomainHEAT

IPO5 PPP2R1B HTT

1.55e-0348893PF02985
DomainA/G_cyclase_CS

GUCY2D ADCY6

2.91e-0317892IPR018297
DomainIontro_rcpt

GRIK1 GRIK2

3.27e-0318892IPR001320
DomainLig_chan-Glu_bd

GRIK1 GRIK2

3.27e-0318892PF10613
DomainIono_rcpt_met

GRIK1 GRIK2

3.27e-0318892IPR001508
DomainGlu/Gly-bd

GRIK1 GRIK2

3.27e-0318892IPR019594
DomainLig_chan-Glu_bd

GRIK1 GRIK2

3.27e-0318892SM00918
DomainLig_chan

GRIK1 GRIK2

3.27e-0318892PF00060
DomainNucleotide_cyclase

GUCY2D ADCY6

3.27e-0318892IPR029787
DomainPBPe

GRIK1 GRIK2

3.27e-0318892SM00079
Domain-

GUCY2D ADCY6

3.27e-03188923.30.70.1230
DomainGUANYLATE_CYCLASE_1

GUCY2D ADCY6

3.64e-0319892PS00452
DomainGuanylate_cyc

GUCY2D ADCY6

3.64e-0319892PF00211
DomainGUANYLATE_CYCLASE_2

GUCY2D ADCY6

3.64e-0319892PS50125
DomainA/G_cyclase

GUCY2D ADCY6

3.64e-0319892IPR001054
DomainCYCc

GUCY2D ADCY6

3.64e-0319892SM00044
Domain-

IPO5 PPP2R1B TOGARAM1 AP3B1 HTT

4.19e-032228951.25.10.10
DomainFA58C

CNTNAP3B CNTNAP3

4.45e-0321892SM00231
DomainFA58C_3

CNTNAP3B CNTNAP3

4.45e-0321892PS50022
DomainFA58C_1

CNTNAP3B CNTNAP3

4.45e-0321892PS01285
DomainFA58C_2

CNTNAP3B CNTNAP3

4.45e-0321892PS01286
DomainDEP

DEPDC4 PREX1

4.87e-0322892PF00610
DomainDEP

DEPDC4 PREX1

4.87e-0322892PS50186
DomainDEP

DEPDC4 PREX1

4.87e-0322892SM00049
DomainDEP_dom

DEPDC4 PREX1

5.32e-0323892IPR000591
DomainF5_F8_type_C

CNTNAP3B CNTNAP3

5.79e-0324892PF00754
DomainFA58C

CNTNAP3B CNTNAP3

5.79e-0324892IPR000421
Pubmed

Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease.

PRKAA1 PRKAA2 HTT

1.85e-08393321768291
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

SLC12A6 DIP2B PPP2R1B TTLL3 MYO5A TBC1D22A ROR2 PRKAA2 XXYLT1 SHPRH G2E3 GRIK1 GRIK2 QSER1 SMYD3 HTT TULP3

3.93e-071489931728611215
Pubmed

Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption.

PRKAA1 PRKAA2 ABCB11

6.43e-07793321195347
Pubmed

Transmembrane topology of the glutamate receptor subunit GluR6.

PRKAA1 GRIK1 GRIK2

1.03e-0689338163463
Pubmed

Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.

GRIK1 GRIK2

7.07e-06293215673679
Pubmed

Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells.

PRKAA1 PRKAA2

7.07e-06293221673972
Pubmed

Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans.

PRKAA1 PRKAA2

7.07e-06293218801964
Pubmed

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status.

PRKAA1 PRKAA2

7.07e-06293221947382
Pubmed

Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation.

PRKAA1 PRKAA2

7.07e-06293232839348
Pubmed

Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

PRKAA1 PRKAA2

7.07e-06293220465544
Pubmed

Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase.

PRKAA1 GRIK2

7.07e-0629328094892
Pubmed

Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase.

PRKAA1 PRKAA2

7.07e-06293219236843
Pubmed

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.

PRKAA1 PRKAA2

7.07e-06293223905686
Pubmed

Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus.

GRIK1 GRIK2

7.07e-06293211182092
Pubmed

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise.

PRKAA1 PRKAA2

7.07e-06293232504885
Pubmed

Adipose tissue-specific knockout of AMPKα1/α2 results in normal AICAR tolerance and glucose metabolism.

PRKAA1 PRKAA2

7.07e-06293231540695
Pubmed

Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.

GSPT2 GSPT1

7.07e-06293215987998
Pubmed

Functional differences between AMPK α1 and α2 subunits in osteogenesis, osteoblast-associated induction of osteoclastogenesis, and adipogenesis.

PRKAA1 PRKAA2

7.07e-06293227600021
Pubmed

Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit.

GRIK1 GRIK2

7.07e-06293214724198
Pubmed

Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice.

PRKAA1 PRKAA2

7.07e-06293223486478
Pubmed

Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

PRKAA1 PRKAA2

7.07e-06293215878932
Pubmed

The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones.

GRIK1 GRIK2

7.07e-06293215539395
Pubmed

AMPK activation regulates neuronal structure in developing hippocampal neurons.

PRKAA1 PRKAA2

7.07e-06293224295634
Pubmed

AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress.

PRKAA1 PRKAA2

7.07e-06293222763120
Pubmed

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.

PRKAA1 PRKAA2

7.07e-06293222233421
Pubmed

RNA editing of human kainate receptor subunits.

GRIK1 GRIK2

7.07e-0629327696618
Pubmed

The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint.

PRKAA1 PRKAA2

7.07e-06293226843621
Pubmed

Phosphorylation and activation of AMP-activated protein kinase (AMPK) by metformin in the human ovary requires insulin.

PRKAA1 PRKAA2

7.07e-06293221209024
Pubmed

Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6.

GRIK1 GRIK2

7.07e-0629328260617
Pubmed

Endothelial AMP-activated protein kinase regulates blood pressure and coronary flow responses through hyperpolarization mechanism in mice.

PRKAA1 PRKAA2

7.07e-06293224855056
Pubmed

AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.

PRKAA1 PRKAA2

7.07e-06293226419588
Pubmed

Autophagy and mitochondrial biogenesis impairment contribute to age-dependent liver injury in experimental sepsis: dysregulation of AMP-activated protein kinase pathway.

PRKAA1 PRKAA2

7.07e-06293228974562
Pubmed

Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models.

PRKAA1 PRKAA2

7.07e-06293212546688
Pubmed

Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.

CNTNAP3B CNTNAP3

7.07e-06293226807827
Pubmed

AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress.

PRKAA1 PRKAA2

7.07e-06293212788940
Pubmed

Skeletal muscle-specific inducible AMPKα1/α2 knockout mice develop muscle weakness, glycogen depletion, and fibrosis that persists during disuse atrophy.

PRKAA1 PRKAA2

7.07e-06293238019084
Pubmed

The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma.

PRKAA1 PRKAA2

7.07e-06293234347929
Pubmed

Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.

GRIK1 GRIK2

7.07e-06293215537878
Pubmed

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK.

PRKAA1 PRKAA2

7.07e-06293231693892
Pubmed

Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer's model mice.

PRKAA1 PRKAA2

7.07e-06293232213711
Pubmed

AMPK knockdown in placental trophoblast cells results in altered morphology and function.

PRKAA1 PRKAA2

7.07e-06293225003940
Pubmed

AMPK-α1 or AMPK-α2 Deletion in Smooth Muscles Does Not Affect the Hypoxic Ventilatory Response or Systemic Arterial Blood Pressure Regulation During Hypoxia.

PRKAA1 PRKAA2

7.07e-06293229928235
Pubmed

[AMPK as a Metabolic Intersection between Diet and Physical Exercise].

PRKAA1 PRKAA2

7.07e-06293230270274
Pubmed

AMPK regulates circadian rhythms in a tissue- and isoform-specific manner.

PRKAA1 PRKAA2

7.07e-06293221483791
Pubmed

AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass.

PRKAA1 PRKAA2

7.07e-06293220399918
Pubmed

Conditional disruption of AMP kinase in dopaminergic neurons promotes Parkinson's disease-associated phenotypes in vivo.

PRKAA1 PRKAA2

7.07e-06293234767944
Pubmed

Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors.

GRIK1 GRIK2

7.07e-06293215358807
Pubmed

Involvement of AMPK in regulating slow-twitch muscle atrophy during hindlimb unloading in mice.

PRKAA1 PRKAA2

7.07e-06293226244519
Pubmed

Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner.

PRKAA1 PRKAA2

7.07e-06293212091379
Pubmed

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.

PRKAA1 PRKAA2

7.07e-06293224665903
Pubmed

Role of AMPK throughout meiotic maturation in the mouse oocyte: evidence for promotion of polar body formation and suppression of premature activation.

PRKAA1 PRKAA2

7.07e-06293220830737
Pubmed

CCCP induces autophagy in an AMPK-independent manner.

PRKAA1 PRKAA2

7.07e-06293222119190
Pubmed

Protein expression alteration in hippocampus upon genetic repression of AMPKα isoforms.

PRKAA1 PRKAA2

7.07e-06293233492732
Pubmed

Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.

GRIK1 GRIK2

7.07e-06293224760837
Pubmed

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice.

PRKAA1 PRKAA2

7.07e-06293229038293
Pubmed

Different expression of the catalytic alpha subunits of the AMP activated protein kinase--an immunohistochemical study in human tissue.

PRKAA1 PRKAA2

7.07e-06293221432774
Pubmed

AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle.

PRKAA1 PRKAA2

7.07e-06293216186119
Pubmed

Role of adenosine 5'-monophosphate-activated protein kinase in α-linolenic acid-induced intestinal lipid metabolism.

PRKAA1 PRKAA2

7.07e-06293226268732
Pubmed

AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling.

PRKAA1 PRKAA2

7.07e-06293227879319
Pubmed

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity.

PRKAA1 PRKAA2

7.07e-06293224652947
Pubmed

Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo.

PRKAA1 PRKAA2

7.07e-06293223288166
Pubmed

AMPK is not required for the effect of metformin on the inhibition of BMP6-induced hepcidin gene expression in hepatocytes.

PRKAA1 PRKAA2

7.07e-06293228978947
Pubmed

Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions.

PRKAA1 PRKAA2

7.07e-06293221239628
Pubmed

Reciprocity Between Skeletal Muscle AMPK Deletion and Insulin Action in Diet-Induced Obese Mice.

PRKAA1 PRKAA2

7.07e-06293232439824
Pubmed

Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus.

GRIK1 GRIK2

7.07e-06293211069933
Pubmed

Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation.

GRIK1 GRIK2

7.07e-06293212947409
Pubmed

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.

CNTNAP3B CNTNAP3

7.07e-06293231150793
Pubmed

AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside.

PRKAA1 PRKAA2

7.07e-06293217324122
Pubmed

Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2.

PRKAA1 PRKAA2

7.07e-06293224420540
Pubmed

Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.

GRIK1 GRIK2

7.07e-06293215928066
Pubmed

Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.

PRKAA1 PRKAA2

7.07e-06293238657612
Pubmed

Coordinated maintenance of muscle cell size control by AMP-activated protein kinase.

PRKAA1 PRKAA2

7.07e-06293220460585
Pubmed

Compound C inhibits hypoxic activation of HIF-1 independent of AMPK.

PRKAA1 PRKAA2

7.07e-06293218036344
Pubmed

Endothelial AMP-Activated Kinase α1 Phosphorylates eNOS on Thr495 and Decreases Endothelial NO Formation.

PRKAA1 PRKAA2

7.07e-06293230217073
Pubmed

Susceptibility to ATP depletion of primary proximal tubular cell cultures derived from mice lacking either the α1 or the α2 isoform of the catalytic domain of AMPK.

PRKAA1 PRKAA2

7.07e-06293224228806
Pubmed

Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.

GRIK1 GRIK2

7.07e-0629328700852
Pubmed

Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell.

PRKAA1 PRKAA2

7.07e-06293221506122
Pubmed

Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction.

PRKAA1 PRKAA2

7.07e-06293227052588
Pubmed

Specific deletion of AMP-activated protein kinase (α1AMPK) in murine oocytes alters junctional protein expression and mitochondrial physiology.

PRKAA1 PRKAA2

7.07e-06293225767884
Pubmed

AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function.

PRKAA1 PRKAA2

7.07e-06293218350549
Pubmed

Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging.

PRKAA1 PRKAA2

7.07e-06293238654312
Pubmed

Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice.

PRKAA1 PRKAA2

7.07e-06293217446219
Pubmed

5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo.

PRKAA1 PRKAA2

7.07e-06293224403081
Pubmed

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

PRKAA1 PRKAA2

7.07e-06293214573616
Pubmed

Q/R site editing controls kainate receptor inhibition by membrane fatty acids.

GRIK1 GRIK2

7.07e-06293216221857
Pubmed

Altered long-term synaptic plasticity and kainate-induced Ca2+ transients in the substantia gelatinosa neurons in GLU(K6)-deficient mice.

GRIK1 GRIK2

7.07e-06293216219388
Pubmed

AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease.

PRKAA1 HTT

7.07e-06293224946181
Pubmed

AMP activated protein kinase is indispensable for myocardial adaptation to caloric restriction in mice.

PRKAA1 PRKAA2

7.07e-06293223527250
Pubmed

Polarized activities of AMPK and BRSK in primary hippocampal neurons.

PRKAA1 PRKAA2

7.07e-06293225788287
Pubmed

Subunit composition and alternative splicing regulate membrane delivery of kainate receptors.

GRIK1 GRIK2

7.07e-06293215014126
Pubmed

Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal.

PRKAA1 PRKAA2

7.07e-06293229610348
Pubmed

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.

PRKAA1 PRKAA2

7.07e-06293219268526
Pubmed

Subunit composition of kainate receptors in hippocampal interneurons.

GRIK1 GRIK2

7.07e-06293211144357
Pubmed

Metabolic regulation of neuronal plasticity by the energy sensor AMPK.

PRKAA1 PRKAA2

7.07e-06293220126541
Pubmed

cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits.

PRKAA1 PREX1

7.07e-06293230530493
Pubmed

Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy.

GRIK1 GRIK2

7.07e-06293225043179
Pubmed

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death.

PRKAA1 PRKAA2

7.07e-06293236028487
Pubmed

AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice.

PRKAA1 PRKAA2

7.07e-06293225609422
Pubmed

AMPK α2 subunit is involved in platelet signaling, clot retraction, and thrombus stability.

PRKAA1 PRKAA2

7.07e-06293220558612
Pubmed

Inhibition of AMP-activated protein kinase accentuates lipopolysaccharide-induced lung endothelial barrier dysfunction and lung injury in vivo.

PRKAA1 PRKAA2

7.07e-06293223306156
InteractionGRIK5 interactions

GRIK1 GRIK2 ADCY6 HTT

1.71e-0620904int:GRIK5
InteractionDENND10P1 interactions

DENND10 DENND10P1 WHAMMP3

7.10e-069903int:DENND10P1
Cytoband10q25

DENND10 SMC3

2.21e-041193210q25
CytobandXq26.1

GPC3 DENND10P1

4.78e-0416932Xq26.1
GeneFamilyGlutamate ionotropic receptor kainate type subunits

GRIK1 GRIK2

1.11e-0456121199
CoexpressionGSE3039_ALPHABETA_CD8_TCELL_VS_B2_BCELL_DN

IPO5 CNNM2 MYO5A INHBA CENPI UBR3 WDR12 MPHOSPH6

4.94e-07200918M6445
Diseaseliver cirrhosis (is_implicated_in)

SERPINA1 ABCB11 C5 FGFR4

7.61e-0643864DOID:5082 (is_implicated_in)
Diseasenon-lobar intracerebral hemorrhage

CELF1 SLC6A15 WDR12 NLRP13

3.51e-0563864EFO_0010178
DiseaseHuntington's disease (is_implicated_in)

PRKAA1 GRIK2 HTT

4.06e-0523863DOID:12858 (is_implicated_in)
Diseasecarnosine measurement

GRIK2 LRRC4C AP3B1

4.63e-0524863EFO_0010470
Diseasesurvival time, pneumonia, septic shock, Sepsis

FER GRIK2

5.02e-054862EFO_0000714, EFO_0003106, EFO_0006834, HP_0100806
Diseasetyrosine-protein kinase TEC measurement

TEC TEC

5.02e-054862EFO_0020830
Diseaseautism spectrum disorder (implicated_via_orthology)

NDST3 CNTNAP3B TAOK3 CNTNAP3 PREX1

8.45e-05152865DOID:0060041 (implicated_via_orthology)
Diseaseintellectual disability (is_implicated_in)

CDKL5 SMC3 CC2D1A

9.17e-0530863DOID:1059 (is_implicated_in)
Diseasemyositis

SLC6A15 TEC TEC

2.02e-0439863EFO_0000783
Diseaseautosomal recessive intellectual developmental disorder (implicated_via_orthology)

CNTNAP3B CNTNAP3

2.32e-048862DOID:0060308 (implicated_via_orthology)
Diseaseneutropenia (is_implicated_in)

C5 AP3B1

2.32e-048862DOID:1227 (is_implicated_in)
Diseaseeye colour measurement

MAP2K4 INHBA ROR2 CNTNAP3 LRRC4C

4.50e-04218865EFO_0009764
Diseaseforced expiratory volume

SERPINA1 GPC3 CELF1 FER DNM3 IFI44L AP3B1 ARHGEF17 PREX1

4.89e-04789869EFO_0004314
DiseaseMetastatic melanoma

CDKL5 MAP2K4 GUCY2D

5.33e-0454863C0278883
Diseaseneurodegenerative disease (implicated_via_orthology)

UBR3 GRIK1 GRIK2 HTT

8.69e-04145864DOID:1289 (implicated_via_orthology)
DiseaseColorectal Carcinoma

NDST3 CDKL5 PPP2R1B TTLL3 ABCD4 ABCB11 SNRNP200 RHEB

1.02e-03702868C0009402
Diseasefibrinogen measurement, coronary artery disease

DIP2B SERPINA1 CNNM2 WDR12

1.09e-03154864EFO_0001645, EFO_0004623
Diseasecystathionine measurement

TEC TEC

1.39e-0319862EFO_0010474
Diseaseectonucleoside triphosphate diphosphohydrolase 5 measurement

SERPINA1 ABCD4

1.70e-0321862EFO_0008115
DiseaseOvarian Serous Adenocarcinoma

CDKL5 MAP2K4

2.04e-0323862C1335177
Diseasecortical thickness change measurement, age at assessment

SLC6A15 GRIK2

2.04e-0323862EFO_0008007, EFO_0021501
Diseasechronic widespread pain

DIP2B MAP2K4

2.04e-0323862EFO_0010099
Diseasesmoking behavior, BMI-adjusted waist-hip ratio

DNM3 SFXN2 FGFR4

2.05e-0386863EFO_0004318, EFO_0007788
Diseaseprostate specific antigen measurement

MAP2K4 SERPINA1 GPC3 SLC6A15

2.26e-03188864EFO_0004624
Diseasepulse pressure measurement

DIP2B PRDM9 CNNM2 CELF1 INHBA TTC16 FER ABCB11 UBR3 TEC TEC

2.36e-0313928611EFO_0005763
DiseaseImpaired glucose tolerance

PRKAA1 PRKAA2

2.41e-0325862C0271650
Diseaselarge artery stroke, coronary artery disease

CNNM2 WDR12

2.41e-0325862EFO_0001645, EFO_0005524
Diseasewhite matter integrity, age at assessment

CELF1 WDR12

2.61e-0326862EFO_0004641, EFO_0008007
Diseaseazoospermia (implicated_via_orthology)

NDST3 ESRRB

2.81e-0327862DOID:14227 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
ELGPMMKLKRHFVAQ

ACSBG2

641

Q5FVE4
KQMLPIVLKMAGDQV

PPP2R1B

531

P30154
VVKMNKRTGQPMIHI

EWSR1

386

Q01844
AMGKLHKEMGQLIVQ

DENND10P1

271

Q6NSW5
LAKKHKPQILMMGNV

CNTNAP3

346

Q9BZ76
VIPMMPEVKNIHQKD

CRYBG3

1636

Q68DQ2
KSLHPLQMGGLKVEM

CRYBG3

2461

Q68DQ2
LLLSVLPQHVAMEMK

ADCY6

341

O43306
NMKVLPGMHHPIQMK

CELF1

81

Q92879
KVPMMKRLGMFNIQH

SERPINA1

241

P01009
VATLLMHMLQVDPLK

PRKAA2

241

P54646
MHMLQVDPLKRATIK

PRKAA2

246

P54646
VLMNHKVFEPVGMKK

DEPDC4

126

Q8N2C3
HPSEMPQLVKGMKLL

EFL1

626

Q7Z2Z2
AILQLQEEGKLHMMK

GRIK1

796

P39086
MEVMKLIGRHKNIIN

FGFR4

521

P22455
KILNDLNMVIKPGEM

ABCB11

436

O95342
NKTLMGPIVMKLVHQ

ABCD4

201

O14678
IPMQFGIIQKHLKTM

AKAP8L

491

Q9ULX6
NIHIGEKKLPIGMKM

AP3B1

916

O00203
QPEMVEAVKKHILNM

INHBA

51

P08476
VNKMVHKPSGQIMAV

MAP2K4

116

P45985
QHLPYQLMEVKAMKL

NDST3

56

O95803
LLLPHMKKIDGMLND

QSER1

1576

Q2KHR3
PMMQKLIILVQDHGQ

PCDHB1

636

Q9Y5F3
KPQVDMRKHVAMTLL

ARHGEF17

1061

Q96PE2
VMHPSKVLELQMNKR

NOX1

301

Q9Y5S8
MVNMLVLGKHLGIPK

PADI4

586

Q9UM07
PIMKADMLKIVQKSH

MAGEB3

131

O15480
LALPMAVIMGQKHEL

NTSR2

166

O95665
LLHMQMVSGPNKIIL

GUCY2D

491

Q02846
MKNQFNLHELKMKGP

GPC3

441

P51654
NVHKMLGIPISNILM

IFI44L

386

Q53G44
GITLQKMEMPKQTRH

HMGN2P46

136

Q86SG4
IPKTIMHLMINNVKD

DNM3

681

Q9UQ16
LVMMPNKHNVEVLGI

GSPT2

461

Q8IYD1
PKMLLDQVMGVNKIS

OR2T4

111

Q8NH00
LAKHKEQKMALPMPT

DIP2B

111

Q9P265
MLNKMTLHPQQIMIG

LRRC4C

1

Q9HCJ2
GGKLVLPMIKEHIMQ

IPO5

351

O00410
QLVMMPNKHNVEVLG

GSPT1

331

P15170
GKLLDMVGKVQIPIM

RHEB

101

Q15382
MVGKVQIPIMLVGNK

RHEB

106

Q15382
QIPIMLVGNKKDLHM

RHEB

111

Q15382
MALRVEQRKHQKGMP

PRDM9

106

Q9NQV7
DIFQKEMLRMGIHIP

G2E3

196

Q7L622
LLPVMQHLAKNVVMV

CCNB1

376

P14635
ADIILPMLAKQQMHI

HTT

1611

P42858
PLHRLTMMIKDKQQV

FER

96

P16591
DMQLGRLHMKTLLPV

C5

746

P01031
MKMVQKAAQAGLPLV

GPAT2

186

Q6NUI2
KMHLRQAKGLEPMLE

CC2D1A

521

Q6P1N0
TLNIIMKMFVPHKEN

DPY19L4

361

Q7Z388
QGKVPMHKLFLEMLE

ESRRB

416

O95718
KLLDLQAKMGMQPHL

CENPI

221

Q92674
AILQLQEEGKLHMMK

GRIK2

781

Q13002
MKIPNIGNVMNKFEI

CDKL5

1

O76039
MVILQDKEHTPKLMG

DIPK1A

206

Q5T7M9
AMGKLHKEMGQLIVQ

DENND10

271

Q8TCE6
GMLMLLPFLLKQHKV

SLC12A6

921

Q9UHW9
KMMANGILKVPAINV

AHCY

166

P23526
VMEQQLKKLGVMPPE

INPP5F

476

Q9Y2H2
TPVKLMRIQHNEGAM

MYBL1

391

P10243
LAKKHKPQILMMGNV

CNTNAP3B

346

Q96NU0
KKVNVPPEKAMMHIN

CFAP221

276

Q4G0U5
MKFLKMGNISQDIIP

SLC6A15

376

Q9H2J7
KILMEFNKMNLPGEV

SMC3

571

Q9UQE7
MQKVKVLHAPLQVML

SFXN2

256

Q96NB2
VMMKLTHPKLVQLYG

TEC

416

P42680
NPEVEKLMLQMNAKH

MPHOSPH6

81

Q99547
HGLLPKCIMQATDIM

PREX1

1606

Q8TCU6
MKKVMEKLHNSIIPD

SHPRH

241

Q149N8
HVMELRQQPKNLKAM

TAOK3

701

Q9H2K8
MELVLGKMNPQKAFL

SCP2D1

116

Q9UJQ7
DMEMPLINQHKQAKL

ROR2

451

Q01974
VQVMKVGKLQLHQGM

SMYD3

371

Q9H7B4
LKHMLQVDPMKRATI

PRKAA1

256

Q13131
MKVKISPQLLLAMHR

CNNM2

616

Q9H8M5
LEQGKKPLTMKRHEM

ZNF93

56

P35789
HKQLGPKIIVVERMM

TRPM5

856

Q9NZQ8
EMLKLVNGNPVVMKD

TTLL3

301

Q9Y4R7
AQPGIQMKVKMLEEL

TBC1D22A

381

Q8WUA7
MQPLEKMALKEAHQP

UBL4B

71

Q8N7F7
LNHNEIGELIRMPKM

SNRNP200

1156

O75643
EMLMKLMIHPLQIQA

UBR3

661

Q6ZT12
MLRLGKGPKVFHNLM

SCN7A

1356

Q01118
KHPQARMLLQKMVAQ

TTC16

236

Q8NEE8
MKLQNMVKFPLTGLD

USP31

656

Q70CQ4
MKIFLKLMKEVGPQQ

TOGARAM1

456

Q9Y4F4
LIKGQFLRMPLDKHM

WDR12

56

Q9GZL7
YKKHLPQLGMQKEME

WHAMMP3

31

Q1A5X7
MSVIIPGMTLNHKQI

TULP3

321

O75386
LEQGKKPLTMKRHEM

ZNF506

56

Q5JVG8
MHQIMPKEILQIIQL

XXYLT1

211

Q8NBI6
TKPQEMKMLLQHVLL

NLRP13

561

Q86W25
LHIGMENKIMQLQRK

MYO5A

921

Q9Y4I1