Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of skin epidermis	KRT2 KRT5 KRT76	1.20e-05	43	21	3	GO:0030280
GeneOntologyMolecularFunction	G-rich strand telomeric DNA binding	RPA2 HNRNPA1	5.76e-05	11	21	2	GO:0098505
GeneOntologyMolecularFunction	single-stranded telomeric DNA binding	RPA2 HNRNPA1	8.16e-05	13	21	2	GO:0043047
GeneOntologyMolecularFunction	sequence-specific single stranded DNA binding	RPA2 HNRNPA1	1.10e-04	15	21	2	GO:0098847
GeneOntologyMolecularFunction	mRNA 3'-UTR binding	HNRNPA1 HNRNPA1L3 FUS ILF3	1.78e-04	276	21	4	GO:0003730
GeneOntologyMolecularFunction	structural constituent of cytoskeleton	KRT2 KRT5 KRT9	3.29e-04	130	21	3	GO:0005200
GeneOntologyMolecularFunction	telomeric DNA binding	RPA2 HNRNPA1	8.02e-04	40	21	2	GO:0042162
GeneOntologyMolecularFunction	structural molecule activity	KRT2 KRT5 KRT9 KRT76 FLG2	1.96e-03	891	21	5	GO:0005198
GeneOntologyMolecularFunction	mRNA binding	HNRNPA1 HNRNPA1L3 FUS ILF3	5.40e-03	694	21	4	GO:0003729
GeneOntologyMolecularFunction	single-stranded RNA binding	HNRNPA1 ILF3	6.00e-03	111	21	2	GO:0003727
GeneOntologyMolecularFunction	chromatin binding	EOMES AHDC1 SUPT6H FUS	6.74e-03	739	21	4	GO:0003682
GeneOntologyMolecularFunction	single-stranded DNA binding	RPA2 HNRNPA1	8.63e-03	134	21	2	GO:0003697
GeneOntologyBiologicalProcess	skin development	KRT2 KRT5 AHDC1 KRT9 KRT76 HRNR FLG2	5.59e-08	373	21	7	GO:0043588
GeneOntologyBiologicalProcess	intermediate filament organization	KRT2 KRT5 KRT9 KRT76	9.21e-07	75	21	4	GO:0045109
GeneOntologyBiologicalProcess	keratinization	KRT2 KRT5 KRT76 HRNR	1.67e-06	87	21	4	GO:0031424
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	KRT2 KRT5 KRT9 KRT76	2.81e-06	99	21	4	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	KRT2 KRT5 KRT9 KRT76	2.92e-06	100	21	4	GO:0045103
GeneOntologyBiologicalProcess	epidermis development	KRT2 KRT5 KRT9 KRT76 HRNR FLG2	4.92e-06	461	21	6	GO:0008544
GeneOntologyBiologicalProcess	keratinocyte differentiation	KRT2 KRT5 KRT76 HRNR	3.62e-05	189	21	4	GO:0030216
GeneOntologyBiologicalProcess	RNA splicing	HNRNPA1 HNRNPA1L3 SUPT6H FAM98A FUS	1.23e-04	502	21	5	GO:0008380
GeneOntologyBiologicalProcess	epidermal cell differentiation	KRT2 KRT5 KRT76 HRNR	1.75e-04	284	21	4	GO:0009913
GeneOntologyBiologicalProcess	regulation of DNA metabolic process	INO80C RPA2 HNRNPA1 SUPT6H FUS	2.12e-04	564	21	5	GO:0051052
GeneOntologyBiologicalProcess	supramolecular fiber organization	KRT2 KRT5 KRT9 KRT76 FUS DVL1	2.92e-04	957	21	6	GO:0097435
GeneOntologyBiologicalProcess	epithelium development	KRT2 KRT5 KRT9 KRT76 HRNR DVL1 FLG2	4.38e-04	1469	21	7	GO:0060429
GeneOntologyBiologicalProcess	regulation of DNA recombination	RPA2 SUPT6H FUS	4.55e-04	150	21	3	GO:0000018
GeneOntologyBiologicalProcess	DNA recombination	INO80C RPA2 SUPT6H FUS	4.69e-04	368	21	4	GO:0006310
GeneOntologyBiologicalProcess	telomere maintenance	INO80C RPA2 HNRNPA1	6.34e-04	168	21	3	GO:0000723
GeneOntologyBiologicalProcess	establishment of skin barrier	HRNR FLG2	7.90e-04	41	21	2	GO:0061436
GeneOntologyBiologicalProcess	telomere organization	INO80C RPA2 HNRNPA1	1.04e-03	199	21	3	GO:0032200
GeneOntologyBiologicalProcess	gastrulation	EOMES AHDC1 DVL1	1.24e-03	212	21	3	GO:0007369
GeneOntologyBiologicalProcess	cellular response to metal ion	HNRNPA1 FOSB FUS	1.36e-03	219	21	3	GO:0071248
GeneOntologyBiologicalProcess	epithelial cell differentiation	KRT2 KRT5 KRT9 KRT76 HRNR	1.53e-03	870	21	5	GO:0030855
GeneOntologyBiologicalProcess	regulation of DNA repair	INO80C RPA2 FUS	1.65e-03	234	21	3	GO:0006282
GeneOntologyBiologicalProcess	protein methylation	FAM98A ILF3	2.04e-03	66	21	2	GO:0006479
GeneOntologyBiologicalProcess	protein alkylation	FAM98A ILF3	2.04e-03	66	21	2	GO:0008213
GeneOntologyCellularComponent	cornified envelope	KRT2 KRT5 HRNR FLG2	6.24e-07	69	21	4	GO:0001533
GeneOntologyCellularComponent	keratin filament	KRT2 KRT5 KRT9 KRT76	2.45e-06	97	21	4	GO:0045095
GeneOntologyCellularComponent	keratohyalin granule	HRNR FLG2	9.59e-06	5	21	2	GO:0036457
GeneOntologyCellularComponent	intermediate filament	KRT2 KRT5 KRT9 KRT76	7.01e-05	227	21	4	GO:0005882
GeneOntologyCellularComponent	intermediate filament cytoskeleton	KRT2 KRT5 KRT9 KRT76	1.24e-04	263	21	4	GO:0045111
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	KRT2 KRT5 KRT9 KRT76 DVL1	1.66e-03	899	21	5	GO:0099513
MousePheno	abnormal foot pad morphology	KRT2 KRT9 KRT76	3.15e-06	26	16	3	MP:0000574
MousePheno	hyperpigmentation	KRT2 KRT9 KRT76	3.96e-06	28	16	3	MP:0001188
MousePheno	increased tail pigmentation	KRT2 KRT76	8.05e-05	12	16	2	MP:0011276
MousePheno	thick epidermis	KRT2 KRT9 KRT76	9.58e-05	80	16	3	MP:0001219
MousePheno	abnormal intercostal muscle morphology	HNRNPA1 ILF3	1.28e-04	15	16	2	MP:0002280
MousePheno	hyperkeratosis	KRT2 KRT9 KRT76	1.36e-04	90	16	3	MP:0001242
MousePheno	abnormal skin appearance	TMEM209 KRT2 AHDC1 KRT9 KRT76	1.39e-04	473	16	5	MP:0009931
MousePheno	increased foot pigmentation	KRT2 KRT76	1.46e-04	16	16	2	MP:0030051
MousePheno	increased foot pad pigmentation	KRT2 KRT76	1.46e-04	16	16	2	MP:0000575
MousePheno	abnormal epidermal layer morphology	KRT2 KRT5 KRT9 KRT76	2.09e-04	271	16	4	MP:0001216
MousePheno	abnormal tongue morphology	TMEM209 HNRNPA1 KRT5	3.03e-04	118	16	3	MP:0000762
MousePheno	abnormal epidermis stratum corneum morphology	KRT2 KRT9 KRT76	4.21e-04	132	16	3	MP:0001240
MousePheno	increased keratinocyte proliferation	KRT2 KRT9	4.24e-04	27	16	2	MP:0009583
MousePheno	abnormal foot pigmentation	KRT2 KRT76	4.56e-04	28	16	2	MP:0009379
MousePheno	abnormal skin morphology	TMEM209 KRT2 KRT5 AHDC1 KRT9 FOSB KRT76	6.39e-04	1455	16	7	MP:0002060
MousePheno	abnormal autopod morphology	KRT2 KRT5 KRT9 KRT76	8.32e-04	390	16	4	MP:0000572
MousePheno	abnormal tail pigmentation	KRT2 KRT76	8.88e-04	39	16	2	MP:0005174
MousePheno	perinatal lethality, complete penetrance	HNRNPA1 KRT5 AHDC1 FUS ILF3	9.23e-04	712	16	5	MP:0011089
MousePheno	abnormal tail morphology	INO80C KRT2 KRT5 KRT76	9.40e-04	403	16	4	MP:0002111
MousePheno	abnormal keratinocyte proliferation	KRT2 KRT9	9.81e-04	41	16	2	MP:0009582
MousePheno	acanthosis	KRT2 KRT9	1.08e-03	43	16	2	MP:0001874
MousePheno	epidermis stratum spinosum hyperplasia	KRT2 KRT9	1.18e-03	45	16	2	MP:0009611
MousePheno	abnormal keratinocyte morphology	KRT2 KRT9	1.70e-03	54	16	2	MP:0002655
MousePheno	abnormal epidermis stratum spinosum morphology	KRT2 KRT9	2.45e-03	65	16	2	MP:0001236
MousePheno	anophthalmia	TMEM209 INO80C AHDC1	2.54e-03	246	16	3	MP:0001293
MousePheno	neonatal lethality, complete penetrance	HNRNPA1 KRT5 FUS ILF3	2.66e-03	534	16	4	MP:0011087
MousePheno	abnormal epidermis stratum granulosum morphology	KRT2 KRT9	2.83e-03	70	16	2	MP:0001239
Domain	Intermediate_filament_CS	KRT2 KRT5 KRT9 KRT76	6.74e-07	63	21	4	IPR018039
Domain	Filament	KRT2 KRT5 KRT9 KRT76	1.09e-06	71	21	4	SM01391
Domain	IF	KRT2 KRT5 KRT9 KRT76	1.16e-06	72	21	4	PS00226
Domain	DVL-1	DVL1P1 DVL1	1.20e-06	2	21	2	IPR008340
Domain	Filament	KRT2 KRT5 KRT9 KRT76	1.22e-06	73	21	4	PF00038
Domain	IF	KRT2 KRT5 KRT9 KRT76	1.44e-06	76	21	4	IPR001664
Domain	Keratin_2_head	KRT2 KRT5 KRT76	2.44e-06	24	21	3	IPR032444
Domain	Keratin_2_head	KRT2 KRT5 KRT76	2.44e-06	24	21	3	PF16208
Domain	Keratin_II	KRT2 KRT5 KRT76	3.13e-06	26	21	3	IPR003054
Domain	Dishevelled_protein_dom	DVL1P1 DVL1	7.21e-06	4	21	2	IPR003351
Domain	Dishevelled	DVL1P1 DVL1	7.21e-06	4	21	2	PF02377
Domain	Dishevelled_fam	DVL1P1 DVL1	7.21e-06	4	21	2	IPR008339
Domain	DIX	DVL1P1 DVL1	2.52e-05	7	21	2	IPR001158
Domain	DIX	DVL1P1 DVL1	2.52e-05	7	21	2	PS50841
Domain	DAX	DVL1P1 DVL1	2.52e-05	7	21	2	SM00021
Domain	DIX	DVL1P1 DVL1	2.52e-05	7	21	2	PF00778
Domain	DEP	DVL1P1 DVL1	2.74e-04	22	21	2	SM00049
Domain	DEP	DVL1P1 DVL1	2.74e-04	22	21	2	PF00610
Domain	DEP	DVL1P1 DVL1	2.74e-04	22	21	2	PS50186
Domain	DEP_dom	DVL1P1 DVL1	3.00e-04	23	21	2	IPR000591
Domain	S100_CABP	HRNR FLG2	4.16e-04	27	21	2	PS00303
Domain	S_100	HRNR FLG2	4.16e-04	27	21	2	PF01023
Domain	S_100	HRNR FLG2	4.47e-04	28	21	2	SM01394
Domain	S100_Ca-bd_sub	HRNR FLG2	4.47e-04	28	21	2	IPR013787
Domain	S100/CaBP-9k_CS	HRNR FLG2	4.47e-04	28	21	2	IPR001751
Domain	Keratin_I	KRT9 KRT76	1.11e-03	44	21	2	IPR002957
Domain	WHTH_DNA-bd_dom	RPA2 DVL1P1 DVL1	2.40e-03	242	21	3	IPR011991
Domain	NA-bd_OB-fold	RPA2 SUPT6H	3.88e-03	83	21	2	IPR012340
Domain	PDZ	DVL1P1 DVL1	1.08e-02	141	21	2	PF00595
Domain	PDZ	DVL1P1 DVL1	1.19e-02	148	21	2	SM00228
Domain	PDZ	DVL1P1 DVL1	1.23e-02	151	21	2	PS50106
Domain	PDZ	DVL1P1 DVL1	1.25e-02	152	21	2	IPR001478
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT2 KRT5 KRT9 KRT76	3.03e-06	87	17	4	MM15351
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT2 KRT5 KRT9 KRT76	1.45e-05	129	17	4	M27649
Pathway	REACTOME_KERATINIZATION	KRT2 KRT5 KRT9 KRT76	2.84e-05	153	17	4	MM15343
Pathway	REACTOME_KERATINIZATION	KRT2 KRT5 KRT9 KRT76	1.11e-04	217	17	4	M27640
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 HRNR FLG2	6.87e-14	286	22	9	32041737
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	KRT2 HNRNPA1 KRT5 SUPT6H KRT9 FAM98A FUS ILF3 HRNR FLG2	1.26e-12	605	22	10	28977666
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3 HRNR	2.68e-12	430	22	9	38172120
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	RPA2 KRT2 KRT5 KRT9 HRNR FLG2	1.20e-11	84	22	6	29563501
Pubmed	Revealing A-Raf functions through its interactome.	KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 HRNR	1.85e-11	187	22	7	29777862
Pubmed	hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.	KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 HRNR FLG2	2.51e-11	346	22	8	25324306
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	RPA2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3 HRNR FLG2	7.56e-11	626	22	9	33644029
Pubmed	EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.	KRT2 KRT5 KRT9 HRNR FLG2	1.93e-10	54	22	5	35474131
Pubmed	E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis.	KRT2 HNRNPA1 KRT5 KRT9 HRNR FLG2	2.17e-10	135	22	6	29859926
Pubmed	Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.	RPA2 KRT2 HNRNPA1 KRT5 FUS ILF3	2.27e-10	136	22	6	26979993
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SEC24C KRT2 HNRNPA1 KRT5 AHDC1 SUPT6H KRT9 ILF3 HRNR FLG2	3.75e-10	1082	22	10	38697112
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 HRNR FLG2	1.10e-09	558	22	8	27591049
Pubmed	Prothymosin-α enhances phosphatase and tensin homolog expression and binds with tripartite motif-containing protein 21 to regulate Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 signaling in human bladder cancer.	KRT2 HNRNPA1 KRT5 KRT9	1.26e-09	24	22	4	30719818
Pubmed	Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis.	KRT2 KRT5 KRT9 FUS	1.26e-09	24	22	4	27507811
Pubmed	TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.	KRT2 KRT5 KRT9 HRNR FLG2	2.79e-09	91	22	5	34445801
Pubmed	A functional reference map of the RNF8 interactome in cancer.	KRT2 KRT5 KRT9 FUS HRNR FLG2	3.88e-09	218	22	6	35831895
Pubmed	FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.	KRT2 HNRNPA1 KRT5 KRT9 ILF3 HRNR	4.57e-09	224	22	6	28443643
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	SEC24C KRT2 HNRNPA1 KRT5 SUPT6H KRT9 FAM98A FUS ILF3 FLG2	4.98e-09	1415	22	10	28515276
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3	5.28e-09	421	22	7	34650049
Pubmed	DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.	KRT2 HNRNPA1 KRT5 KRT9 HRNR FLG2	6.56e-09	238	22	6	35864588
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	SEC24C RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3	6.97e-09	707	22	8	19738201
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	KRT2 KRT5 FUS ILF3 HRNR FLG2	7.80e-09	245	22	6	35652658
Pubmed	Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.	HNRNPA1 FAM98A FUS ILF3 HRNR FLG2	1.11e-08	260	22	6	36199071
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	SEC24C TMEM209 RPA2 HNRNPA1 FAM98A FUS ILF3	1.38e-08	484	22	7	31995728
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	KRT2 HNRNPA1 KRT5 KRT9 FAM98A KRT76 FUS ILF3 HRNR	1.58e-08	1153	22	9	29845934
Pubmed	Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.	KRT2 KRT5 KRT9 FUS HRNR FLG2	2.09e-08	289	22	6	37132043
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	KRT2 KRT5 KRT9 FUS ILF3 HRNR	2.50e-08	298	22	6	30737378
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	KRT2 HNRNPA1 KRT5 KRT9 ILF3 HRNR	4.58e-08	330	22	6	32529326
Pubmed	RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.	KRT2 KRT5 KRT9 KRT76	4.64e-08	57	22	4	31862882
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS HRNR	4.75e-08	580	22	7	35676659
Pubmed	The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.	KRT2 HNRNPA1 KRT5 KRT9 FOSB FUS ILF3	6.26e-08	604	22	7	37616343
Pubmed	SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.	KRT2 HNRNPA1 KRT5 KRT9 FUS HRNR	6.82e-08	353	22	6	27545878
Pubmed	New consensus nomenclature for mammalian keratins.	KRT2 KRT5 KRT9 KRT76	6.98e-08	63	22	4	16831889
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	ILF3 HRNR FLG2	1.22e-07	16	22	3	31823782
Pubmed	DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2.	KRT2 HNRNPA1 KRT9 FUS	1.27e-07	73	22	4	35973989
Pubmed	Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.	RPA2 KRT2 KRT5 KRT9 HRNR	1.35e-07	197	22	5	23686814
Pubmed	Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.	KRT2 HNRNPA1 KRT9 FUS	1.42e-07	75	22	4	31527668
Pubmed	Diverse Ras-related GTPase DIRAS2, downregulated by PSMD2 in a proteasome-mediated way, inhibits colorectal cancer proliferation by blocking NF-κB signaling.	KRT2 KRT9 HRNR	2.11e-07	19	22	3	35173535
Pubmed	Proteomic characterization of the human sperm nucleus.	KRT2 KRT5 KRT9 KRT76 HRNR FLG2	2.43e-07	438	22	6	21630459
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SEC24C KRT2 HNRNPA1 KRT5 KRT9 HRNR FLG2	3.44e-07	777	22	7	35844135
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	3.82e-07	2	22	2	8644734
Pubmed	Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.	FOSB FUS	3.82e-07	2	22	2	31262712
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 HRNR FLG2	5.79e-07	1257	22	8	36526897
Pubmed	Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.	KRT5 FUS HRNR FLG2	5.93e-07	107	22	4	32989256
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	KRT2 KRT5 KRT9 KRT76 FUS	5.97e-07	266	22	5	19380743
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	KRT2 HNRNPA1 KRT5 FAM98A FUS ILF3 HRNR	6.00e-07	844	22	7	25963833
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	TMEM209 INO80C RPA2 HNRNPA1 AHDC1 SUPT6H FUS ILF3	7.21e-07	1294	22	8	30804502
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	SEC24C RPA2 KRT2 HNRNPA1 KRT9 FAM98A FUS ILF3	8.28e-07	1318	22	8	30463901
Pubmed	Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.	HNRNPA1 FUS ILF3	8.82e-07	30	22	3	15782174
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	KRT2 KRT5 KRT9 KRT76 HRNR FLG2	1.06e-06	564	22	6	21565611
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	HRNR FLG2	1.15e-06	3	22	2	23403047
Pubmed	TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT-GSK-3β-β-Catenin Signaling Pathway.	KRT2 HNRNPA1 KRT5 KRT9 ILF3	1.17e-06	305	22	5	33194618
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	SEC24C HNRNPA1 AHDC1 SUPT6H FAM98A ILF3	1.75e-06	615	22	6	31048545
Pubmed	The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.	KRT2 HNRNPA1 KRT5 KRT76	1.79e-06	141	22	4	32322062
Pubmed	ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.	KRT2 HNRNPA1 KRT9 FUS ILF3	1.88e-06	336	22	5	31253590
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	KRT2 KRT5 SUPT6H KRT9 FLG2	1.99e-06	340	22	5	29478914
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	SEC24C HNRNPA1 KRT5 SUPT6H FUS ILF3 HRNR	2.18e-06	1024	22	7	24711643
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	KRT2 HNRNPA1 KRT5 KRT9 HRNR FLG2	2.22e-06	641	22	6	36057605
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL1P1 DVL1	2.29e-06	4	22	2	8817329
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL1P1 DVL1	2.29e-06	4	22	2	9192851
Pubmed	Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.	DVL1P1 DVL1	2.29e-06	4	22	2	20639201
Pubmed	Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.	SEC24C KRT2 KRT9	2.31e-06	41	22	3	34638806
Pubmed	TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.	TMEM209 RPA2 KRT9 FUS	2.41e-06	152	22	4	28192407
Pubmed	RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.	KRT2 KRT5 KRT9 FUS	2.68e-06	156	22	4	26170170
Pubmed	A Mass Spectrometry-Based Profiling of Interactomes of Viral DDB1- and Cullin Ubiquitin Ligase-Binding Proteins Reveals NF-κB Inhibitory Activity of the HIV-2-Encoded Vpx.	KRT2 KRT9 FUS	3.06e-06	45	22	3	30619335
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	KRT2 HNRNPA1 KRT9 FAM98A FUS ILF3	3.07e-06	678	22	6	30209976
Pubmed	PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer.	KRT2 KRT5 KRT9	3.28e-06	46	22	3	36147463
Pubmed	The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.	KRT2 KRT5 KRT9 ILF3	3.68e-06	169	22	4	23084401
Pubmed	Identification of DeltaNp63alpha protein interactions by mass spectrometry.	SEC24C KRT5 FUS	3.73e-06	48	22	3	20085233
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	KRT2 HNRNPA1 KRT9 FAM98A FUS ILF3	3.81e-06	704	22	6	32994395
Pubmed	Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR.	FUS ILF3	3.82e-06	5	22	2	11438536
Pubmed	cDNA cloning of human hnRNP protein A1 reveals the existence of multiple mRNA isoforms.	HNRNPA1 HNRNPA1L3	3.82e-06	5	22	2	2836799
Pubmed	An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.	HNRNPA1 FUS ILF3 HRNR FLG2	4.24e-06	397	22	5	21319273
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	SEC24C FAM98A FUS HRNR FLG2	4.40e-06	400	22	5	35013556
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	KRT2 HNRNPA1 KRT9 FAM98A FUS ILF3	4.51e-06	725	22	6	27025967
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3	4.65e-06	1149	22	7	35446349
Pubmed	Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.	KRT2 KRT5 KRT9 FAM98A ILF3	5.45e-06	418	22	5	32552912
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	TMEM209 RPA2 SUPT6H FUS ILF3	6.99e-06	440	22	5	34244565
Pubmed	Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.	KRT2 KRT5 KRT9	7.34e-06	60	22	3	31220272
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	KRT2 KRT5 KRT9 ILF3	7.44e-06	202	22	4	24639526
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	KRT2 FUS HRNR DVL1	7.59e-06	203	22	4	35012549
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	KRT2 KRT5 KRT9 ILF3 HRNR	7.87e-06	451	22	5	36168627
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	SEC24C RPA2 HNRNPA1 AHDC1 FUS ILF3 DVL1	7.96e-06	1247	22	7	27684187
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	KRT2 HNRNPA1 KRT5 KRT9 ILF3 FLG2	8.09e-06	803	22	6	36517590
Pubmed	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.	KRT5 HRNR FLG2	8.11e-06	62	22	3	26644517
Pubmed	Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).	FUS HRNR FLG2	9.35e-06	65	22	3	32120844
Pubmed	The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.	HNRNPA1 FUS ILF3	9.35e-06	65	22	3	32521226
Pubmed	SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication.	HNRNPA1 FAM98A FUS ILF3	9.69e-06	216	22	4	37640791
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	HNRNPA1 SUPT6H FUS ILF3	1.04e-05	220	22	4	34091597
Pubmed	Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis.	KRT2 HNRNPA1 KRT5 KRT9	1.06e-05	221	22	4	31796584
Pubmed	A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).	DVL1P1 DVL1	1.07e-05	8	22	2	19643732
Pubmed	GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.	FUS ILF3 HRNR FLG2	1.10e-05	223	22	4	33731348
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	KRT2 KRT5 KRT9 FUS FLG2	1.15e-05	488	22	5	31324722
Pubmed	Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment.	SEC24C HNRNPA1 KRT9 FUS ILF3	1.19e-05	491	22	5	22623428
Pubmed	PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.	FUS ILF3	1.37e-05	9	22	2	11850402
Pubmed	Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization.	HNRNPA1 ILF3	1.37e-05	9	22	2	12565831
Pubmed	Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.	HNRNPA1 FUS ILF3 HRNR	1.37e-05	236	22	4	36339263
Pubmed	Mapping Extracellular Protein-Protein Interactions Using Extracellular Proximity Labeling (ePL).	HNRNPA1 KRT5 KRT9 ILF3	1.64e-05	247	22	4	39238192
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	TMEM209 ZCCHC14 HNRNPA1 KRT5 KRT9 FAM98A	1.77e-05	922	22	6	27609421
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SEC24C KRT2 HNRNPA1 KRT5 FAM98A KRT76 ILF3	1.95e-05	1431	22	7	37142655
Interaction	CUL2 interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FAM98A KRT76 FUS ILF3 HRNR FLG2	3.40e-12	591	21	11	int:CUL2
Interaction	FBP1 interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 HRNR FLG2	3.02e-11	348	21	9	int:FBP1
Interaction	KRT17 interactions	KRT2 HNRNPA1 KRT5 KRT9 KRT76 ILF3 HRNR FLG2	9.46e-11	252	21	8	int:KRT17
Interaction	DCUN1D1 interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 FLG2	1.89e-10	275	21	8	int:DCUN1D1
Interaction	DDX3X interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3 HRNR FLG2	2.95e-10	651	21	10	int:DDX3X
Interaction	CHD3 interactions	KRT2 HNRNPA1 KRT5 SUPT6H KRT9 FAM98A FUS ILF3 HRNR FLG2	1.28e-09	757	21	10	int:CHD3
Interaction	ARAF interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 HRNR	2.24e-09	376	21	8	int:ARAF
Interaction	CUL5 interactions	SEC24C RPA2 KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3	2.25e-09	567	21	9	int:CUL5
Interaction	DDX39B interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 HRNR FLG2	2.36e-09	570	21	9	int:DDX39B
Interaction	COPS5 interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FAM98A KRT76 FUS ILF3 HRNR FLG2	2.64e-09	1102	21	11	int:COPS5
Interaction	CAND1 interactions	SEC24C RPA2 KRT2 HNRNPA1 KRT5 KRT9 FAM98A KRT76 FUS ILF3	6.34e-09	894	21	10	int:CAND1
Interaction	CHD4 interactions	RPA2 KRT2 HNRNPA1 KRT5 SUPT6H KRT9 FUS ILF3 HRNR FLG2	1.00e-08	938	21	10	int:CHD4
Interaction	METTL3 interactions	RPA2 KRT2 KRT5 KRT9 FUS HRNR FLG2	1.08e-08	287	21	7	int:METTL3
Interaction	MECP2 interactions	SEC24C KRT2 HNRNPA1 KRT5 AHDC1 SUPT6H KRT9 FUS ILF3 HRNR FLG2	1.34e-08	1287	21	11	int:MECP2
Interaction	ZUP1 interactions	RPA2 KRT2 KRT5 KRT9 HRNR FLG2	1.85e-08	174	21	6	int:ZUP1
Interaction	BTF3 interactions	RPA2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3 HRNR FLG2	4.43e-08	799	21	9	int:BTF3
Interaction	ACE2 interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3 HRNR FLG2	4.82e-08	1106	21	10	int:ACE2
Interaction	METTL14 interactions	KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 HRNR FLG2	4.87e-08	558	21	8	int:METTL14
Interaction	LARP7 interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 KRT76 FUS ILF3 HRNR FLG2	5.12e-08	1113	21	10	int:LARP7
Interaction	RBM45 interactions	RPA2 KRT2 HNRNPA1 KRT5 FUS ILF3	5.21e-08	207	21	6	int:RBM45
Interaction	EFNA3 interactions	RPA2 KRT2 KRT5 KRT9 HRNR	7.65e-08	108	21	5	int:EFNA3
Interaction	PHGDH interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3	8.12e-08	385	21	7	int:PHGDH
Interaction	MEPCE interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 KRT76 FUS ILF3 HRNR	8.25e-08	859	21	9	int:MEPCE
Interaction	CYLD interactions	KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 HRNR DVL1 FLG2	9.02e-08	868	21	9	int:CYLD
Interaction	NEDD8 interactions	KRT2 HNRNPA1 KRT5 KRT9 KRT76 FUS ILF3	9.34e-08	393	21	7	int:NEDD8
Interaction	ARF5 interactions	RPA2 KRT2 KRT5 KRT9 HRNR FLG2	9.99e-08	231	21	6	int:ARF5
Interaction	HEXIM1 interactions	KRT2 HNRNPA1 KRT5 KRT9 FAM98A KRT76 FUS ILF3 HRNR	1.39e-07	913	21	9	int:HEXIM1
Interaction	AAR2 interactions	SEC24C RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3	1.71e-07	657	21	8	int:AAR2
Interaction	HNRNPA1 interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 HRNR FLG2	1.86e-07	945	21	9	int:HNRNPA1
Interaction	TRIM31 interactions	KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3	2.49e-07	454	21	7	int:TRIM31
Interaction	MYCN interactions	SEC24C KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3 HRNR FLG2	3.67e-07	1373	21	10	int:MYCN
Interaction	CUL4B interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 KRT76 FUS ILF3	3.74e-07	728	21	8	int:CUL4B
Interaction	PIH1D1 interactions	SEC24C KRT2 HNRNPA1 KRT5 SUPT6H KRT9 FUS ILF3	3.86e-07	731	21	8	int:PIH1D1
Interaction	EIF4A3 interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3	4.71e-07	499	21	7	int:EIF4A3
Interaction	EFTUD2 interactions	SEC24C RPA2 KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3 FLG2	6.06e-07	1449	21	10	int:EFTUD2
Interaction	PRPF8 interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3 FLG2	6.07e-07	776	21	8	int:PRPF8
Interaction	ARIH2 interactions	SEC24C KRT2 HNRNPA1 KRT9 FUS ILF3	6.08e-07	314	21	6	int:ARIH2
Interaction	FAF1 interactions	KRT2 HNRNPA1 KRT5 KRT9 ILF3 HRNR	8.72e-07	334	21	6	int:FAF1
Interaction	RNF208 interactions	KRT2 KRT5 KRT9 KRT76	1.01e-06	75	21	4	int:RNF208
Interaction	PHTF1 interactions	KRT2 KRT5 KRT76	1.10e-06	20	21	3	int:PHTF1
Interaction	FN1 interactions	SEC24C RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3	1.19e-06	848	21	8	int:FN1
Interaction	HDAC2 interactions	RPA2 KRT2 KRT5 KRT9 FOSB FUS ILF3 HRNR	1.38e-06	865	21	8	int:HDAC2
Interaction	WTAP interactions	KRT2 KRT5 KRT9 HRNR FLG2	1.41e-06	194	21	5	int:WTAP
Interaction	LGALS9 interactions	SEC24C TMEM209 RPA2 HNRNPA1 FAM98A FUS ILF3	1.41e-06	588	21	7	int:LGALS9
Interaction	CUL1 interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3	1.52e-06	876	21	8	int:CUL1
Interaction	SRA1 interactions	SEC24C HNRNPA1 FOSB ILF3	1.52e-06	83	21	4	int:SRA1
Interaction	DDX24 interactions	RPA2 KRT2 HNRNPA1 KRT5 KRT9 HRNR FLG2	1.55e-06	596	21	7	int:DDX24
Interaction	KRT12 interactions	KRT2 KRT5 KRT76	1.95e-06	24	21	3	int:KRT12
Interaction	MIDN interactions	KRT2 HNRNPA1 KRT5 KRT9 FOSB FUS ILF3	2.15e-06	626	21	7	int:MIDN
Interaction	RLIM interactions	KRT2 KRT5 KRT9 FUS HRNR FLG2	2.21e-06	392	21	6	int:RLIM
Interaction	SNRNP40 interactions	RPA2 HNRNPA1 AHDC1 SUPT6H FUS ILF3 DVL1	2.41e-06	637	21	7	int:SNRNP40
Interaction	COPS6 interactions	RPA2 KRT2 KRT5 KRT9 KRT76 FUS	2.78e-06	408	21	6	int:COPS6
Interaction	RNF8 interactions	KRT2 KRT5 KRT9 FUS HRNR FLG2	3.34e-06	421	21	6	int:RNF8
Interaction	DSP interactions	RPA2 HNRNPA1 KRT5 ILF3 HRNR FLG2	3.43e-06	423	21	6	int:DSP
Interaction	EFNA1 interactions	KRT2 KRT5 KRT9 HRNR	3.60e-06	103	21	4	int:EFNA1
Interaction	RC3H1 interactions	KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS ILF3	3.61e-06	677	21	7	int:RC3H1
Interaction	KRT28 interactions	KRT2 KRT5 KRT76	3.89e-06	30	21	3	int:KRT28
Interaction	NDN interactions	KRT2 HNRNPA1 KRT5 KRT9 ILF3 HRNR	5.08e-06	453	21	6	int:NDN
Interaction	UFL1 interactions	RPA2 KRT2 HNRNPA1 KRT9 FAM98A FUS ILF3 FLG2	5.11e-06	1031	21	8	int:UFL1
Interaction	RPS6KB2 interactions	KRT2 HNRNPA1 KRT5 KRT9 FUS	6.02e-06	261	21	5	int:RPS6KB2
Interaction	KRT25 interactions	KRT2 KRT5 KRT76	6.25e-06	35	21	3	int:KRT25
Interaction	PICALM interactions	SEC24C RPA2 HNRNPA1 FUS ILF3	6.25e-06	263	21	5	int:PICALM
Interaction	MCM2 interactions	RPA2 KRT2 HNRNPA1 KRT5 FAM98A FUS ILF3 HRNR	7.26e-06	1081	21	8	int:MCM2
Interaction	BTRC interactions	HNRNPA1 FAM98A FUS ILF3 HRNR DVL1 FLG2	8.78e-06	775	21	7	int:BTRC
Interaction	IGF2BP1 interactions	SEC24C RPA2 HNRNPA1 FAM98A FUS ILF3	9.79e-06	508	21	6	int:IGF2BP1
Interaction	EIF3F interactions	RPA2 KRT2 HNRNPA1 KRT9 FUS	1.11e-05	296	21	5	int:EIF3F
Interaction	SCAF4 interactions	RPA2 HNRNPA1 SUPT6H FUS	1.25e-05	141	21	4	int:SCAF4
Interaction	KRT32 interactions	KRT2 KRT5 KRT76	1.26e-05	44	21	3	int:KRT32
Interaction	ARL4D interactions	KRT2 HNRNPA1 KRT9 HRNR	1.44e-05	146	21	4	int:ARL4D
Interaction	WWP2 interactions	SEC24C HNRNPA1 AHDC1 SUPT6H FAM98A ILF3 DVL1	1.48e-05	840	21	7	int:WWP2
Interaction	CUL4A interactions	RPA2 KRT2 KRT9 KRT76 FUS HRNR FLG2	1.65e-05	854	21	7	int:CUL4A
Interaction	KRT84 interactions	KRT2 KRT5 KRT76	1.74e-05	49	21	3	int:KRT84
Interaction	YLPM1 interactions	RPA2 HNRNPA1 FUS ILF3	2.06e-05	160	21	4	int:YLPM1
Interaction	KRT6A interactions	KRT2 HNRNPA1 KRT5 KRT76	2.06e-05	160	21	4	int:KRT6A
Interaction	DIRAS2 interactions	KRT2 KRT9 HRNR	2.09e-05	52	21	3	int:DIRAS2
Interaction	TNF interactions	KRT2 HNRNPA1 KRT5 KRT9 FUS	2.16e-05	340	21	5	int:TNF
Interaction	EWSR1 interactions	SEC24C RPA2 KRT2 HNRNPA1 FUS ILF3 HRNR	2.42e-05	906	21	7	int:EWSR1
Interaction	HSF1 interactions	SEC24C HNRNPA1 SUPT6H FUS ILF3 HRNR	2.74e-05	609	21	6	int:HSF1
Interaction	HDAC6 interactions	KRT2 HNRNPA1 KRT5 KRT9 FAM98A FUS HRNR	2.85e-05	929	21	7	int:HDAC6
Interaction	BAP1 interactions	TMEM209 RPA2 KRT2 HNRNPA1 KRT5 KRT9 FUS ILF3	3.02e-05	1314	21	8	int:BAP1
Interaction	PARP1 interactions	SEC24C RPA2 SUPT6H FAM98A FUS ILF3 HRNR FLG2	3.06e-05	1316	21	8	int:PARP1
Interaction	INSIG2 interactions	KRT2 HNRNPA1 KRT5 KRT76	3.06e-05	177	21	4	int:INSIG2
Interaction	KRT15 interactions	KRT2 HNRNPA1 KRT5 KRT76	3.13e-05	178	21	4	int:KRT15
Interaction	IQCB1 interactions	KRT2 KRT5 KRT9 HRNR FLG2	3.24e-05	370	21	5	int:IQCB1
Interaction	NKX2-1 interactions	TMEM209 RPA2 KRT9 FUS	3.27e-05	180	21	4	int:NKX2-1
Interaction	OGT interactions	RPA2 KRT2 HNRNPA1 KRT9 FAM98A FUS ILF3	3.29e-05	950	21	7	int:OGT
Interaction	TRIM37 interactions	KRT2 HNRNPA1 KRT5 KRT9 ILF3 HRNR	3.31e-05	630	21	6	int:TRIM37
Interaction	DSG1 interactions	RPA2 HNRNPA1 HRNR FLG2	3.56e-05	184	21	4	int:DSG1
Interaction	XAB2 interactions	RPA2 HNRNPA1 FUS ILF3	3.72e-05	186	21	4	int:XAB2
Interaction	KRT20 interactions	KRT2 KRT5 KRT76	3.72e-05	63	21	3	int:KRT20
Interaction	KRT10 interactions	KRT2 HNRNPA1 KRT5 KRT76	3.80e-05	187	21	4	int:KRT10
Interaction	KRT14 interactions	KRT2 HNRNPA1 KRT5 KRT76	4.21e-05	192	21	4	int:KRT14
Interaction	KRT5 interactions	KRT2 HNRNPA1 KRT5 KRT76	4.30e-05	193	21	4	int:KRT5
Interaction	DCPS interactions	KRT2 KRT5 SUPT6H KRT9 FLG2	4.38e-05	394	21	5	int:DCPS
Interaction	RAVER1 interactions	RPA2 HNRNPA1 FUS ILF3	4.38e-05	194	21	4	int:RAVER1
Interaction	RC3H2 interactions	KRT2 HNRNPA1 KRT9 FAM98A FUS ILF3	4.56e-05	667	21	6	int:RC3H2
Interaction	NSRP1 interactions	RPA2 HNRNPA1 FAM98A ILF3	4.65e-05	197	21	4	int:NSRP1
Interaction	KRT16 interactions	KRT2 HNRNPA1 KRT5 KRT76	4.65e-05	197	21	4	int:KRT16
Interaction	MIR138-1 interactions	HNRNPA1 FAM98A FUS	4.68e-05	68	21	3	int:MIR138-1
Interaction	NR2C2 interactions	SEC24C RPA2 KRT2 HNRNPA1 KRT9 FAM98A FUS ILF3	4.85e-05	1403	21	8	int:NR2C2
Cytoband	12q13.13	KRT2 KRT5 KRT76	4.48e-06	67	22	3	12q13.13
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	KRT2 HNRNPA1 KRT5 KRT76	4.56e-05	423	22	4	chr12q13
Cytoband	1q21.3	HRNR FLG2	1.44e-03	117	22	2	1q21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1p35	RPA2 AHDC1	1.96e-03	137	22	2	chr1p35
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	HRNR FLG2	1.59e-02	404	22	2	chr1q21
GeneFamily	Keratins, type II	KRT2 KRT5 KRT76	1.34e-06	27	15	3	609
GeneFamily	EF-hand domain containing\|S100 fused type protein family	HRNR FLG2	1.35e-05	7	15	2	1350
GeneFamily	RNA binding motif containing	HNRNPA1 FUS	1.31e-02	213	15	2	725
GeneFamily	EF-hand domain containing	HRNR FLG2	1.38e-02	219	15	2	863
Coexpression	BENPORATH_SOX2_TARGETS	EOMES INO80C ZCCHC14 HNRNPA1 FAM98A FUS ILF3	1.08e-06	734	21	7	M3835
ToppCell	Enterocyte_Progenitors\|World / shred on cell type and cluster	HNRNPA1 FOSB FUS ILF3	2.55e-06	199	22	4	776bcc887927dea9ebd76ec4338ce2225c319c2c
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KRT2 SUPT6H KRT9	4.73e-05	144	22	3	e2a2f260f5ebaaef46248d199c407a15ce9d024a
ToppCell	E16.5-samps\|World / Age Group, Lineage, Cell class and subclass	HNRNPA1 AHDC1 ILF3	5.23e-05	149	22	3	e94d075f68c1c70c89fab50b1b765b5dda650d09
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT5 KRT9 FLG2	7.74e-05	170	22	3	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT5 KRT9 FLG2	7.74e-05	170	22	3	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	C_00\|World / shred on cell type and cluster	FOSB FUS ILF3	9.02e-05	179	22	3	da2dadc3266ffebd4a34ac61bfa05fddcadcde4c
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HNRNPA1 KRT5 FOSB	1.09e-04	191	22	3	4180521a8c5e0ad629cacdd22dc6a94e94b28816
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT5 FOSB FUS	1.13e-04	193	22	3	739fb2a57772a800a2e94bdd6c71285bb2c162a7
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HNRNPA1 FOSB FUS	1.20e-04	197	22	3	9af431323da6d099459b7360af40e5df998cffbd
ToppCell	systemic_lupus_erythematosus-flare\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RPA2 HNRNPA1 FUS	1.22e-04	198	22	3	4c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell	control-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EOMES RPA2 FOSB	1.22e-04	198	22	3	14bd612e9f9358ebff6cf8dda6a3165de9e4e3b0
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HNRNPA1 FOSB FUS	1.23e-04	199	22	3	c007cd51577e31553395ceaed70ad447e5854546
Computational	Neighborhood of BUB3	SEC24C RPA2 FUS ILF3	3.52e-04	277	14	4	MORF_BUB3
Computational	Neighborhood of HDAC2	SEC24C RPA2 FUS ILF3	3.67e-04	280	14	4	MORF_HDAC2
Computational	Genes in the cancer module 68.	KRT2 KRT5	5.03e-04	26	14	2	MODULE_68
Computational	Keratin.	KRT2 KRT5	5.03e-04	26	14	2	MODULE_298
Computational	Developmental processes.	KRT2 KRT5 KRT9 DVL1	7.08e-04	333	14	4	MODULE_220
Computational	Neighborhood of FBL	HNRNPA1 FUS ILF3	7.09e-04	140	14	3	MORF_FBL
Computational	Neighborhood of RAF1	HNRNPA1 FUS	1.38e-03	43	14	2	GCM_RAF1
Computational	Neighborhood of ANP32B	HNRNPA1 FUS ILF3	1.93e-03	198	14	3	MORF_ANP32B
Computational	Neighborhood of DENR	HNRNPA1 FUS	1.94e-03	51	14	2	GNF2_DENR
Computational	Neighborhood of ACP1	HNRNPA1 FUS ILF3	2.31e-03	211	14	3	MORF_ACP1
Computational	Neighborhood of DDX5	HNRNPA1 FUS	3.13e-03	65	14	2	GCM_DDX5
Computational	Neighborhood of UBE2I	HNRNPA1 FUS ILF3	3.26e-03	238	14	3	MORF_UBE2I
Computational	Intermediate filaments and MT.	KRT2 KRT5	3.42e-03	68	14	2	MODULE_438
Computational	Neighborhood of EIF3S2	RPA2 FUS ILF3	3.58e-03	246	14	3	MORF_EIF3S2
Computational	Neighborhood of RBBP6	HNRNPA1 FUS	3.62e-03	70	14	2	GNF2_RBBP6
Computational	Neighborhood of CDK2	RPA2 FUS	3.82e-03	72	14	2	MORF_CDK2
Drug	teleocidin B	RPA2 KRT2 KRT5 KRT9 KRT76	6.16e-08	123	20	5	CID000072425
Drug	sulfur mustard	KRT2 KRT5 KRT9 KRT76	4.58e-06	130	20	4	CID000010461
Drug	homocysteine thiolactone	KRT2 KRT5 KRT9 KRT76	4.72e-06	131	20	4	CID000107712
Drug	phenyl isocyanate	KRT5 KRT9	1.10e-05	6	20	2	ctd:C025319
Drug	al-Badry	KRT2 KRT5 KRT9 KRT76	1.18e-05	165	20	4	CID000004545
Drug	Velcade (bortezomib	KRT2 KRT5 KRT9 KRT76 FUS	1.47e-05	374	20	5	CID000093860
Disease	neurodegenerative disease (implicated_via_orthology)	HNRNPA1 HNRNPA1L3 DVL1P1 DVL1	3.82e-06	145	22	4	DOID:1289 (implicated_via_orthology)
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	5.30e-06	5	22	2	DOID:11198 (is_implicated_in)
Disease	myopathy (implicated_via_orthology)	HNRNPA1 HNRNPA1L3	5.86e-04	48	22	2	DOID:423 (implicated_via_orthology)
Disease	lung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma	DVL1P1 DVL1	6.88e-04	52	22	2	EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Disease	Amyotrophic Lateral Sclerosis	HNRNPA1 FUS	8.55e-04	58	22	2	C0002736
Disease	Malignant neoplasm of breast	EOMES ZCCHC14 KRT5 KRT76 FUS	9.94e-04	1074	22	5	C0006142
Disease	nicotine dependence	DVL1P1 DVL1	1.54e-03	78	22	2	EFO_0003768
Disease	white matter microstructure measurement	HNRNPA1L3 KRT9 FAM98A	2.93e-03	390	22	3	EFO_0005674

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSGGGGGPGTYQYSQ	EOMES	221	O95936
SGRGSYYSTGAPSGQ	AHDC1	811	Q5TGY3
NQGGYGGSSSSSSYG	HNRNPA1L3	256	A0A2R8Y4L2
GYKGGSSSSSSSGYG	KRT76	536	Q01546
GSGSSQSTGFGQYGS	FLG2	646	Q5D862
SSQSTGFGQYGSGSG	FLG2	801	Q5D862
YSYGGGSGGGFSASS	KRT9	71	P35527
YGTQSTPQGYGSTGG	FUS	66	P35637
TPQGYGSTGGYGSSQ	FUS	71	P35637
SSSGGGYSSGSSSYG	KRT2	526	P35908
GYSSGSSSYGSGGRQ	KRT2	531	P35908
SSVSSGYGSGSGYGG	KRT5	496	P13647
GGGLAGGSSGSYYSS	KRT5	521	P13647
GGSSGSYYSSSSGGV	KRT5	526	P13647
SYYSSSSGGVGLGGG	KRT5	531	P13647
SSGPYVSGSGYSSGF	HRNR	451	Q86YZ3
GSRQSSSYGPHGYGS	HRNR	551	Q86YZ3
SSYGPHGYGSGRSSS	HRNR	556	Q86YZ3
SGSGQSSSYGPYRSG	HRNR	1016	Q86YZ3
SGSGQSSSYSPYGSG	HRNR	1486	Q86YZ3
SGSGQSSSYGPYGSG	HRNR	1956	Q86YZ3
SSSYGPYGSGSGWSS	HRNR	1961	Q86YZ3
SGSGQSSSYSPYGSG	HRNR	2426	Q86YZ3
GTSYSTPGMSGYSSG	FOSB	101	P53539
TPGMSGYSSGGASGS	FOSB	106	P53539
SPSHNGSSGGGYGAS	INO80C	26	Q6PI98
YSNSYNSPGGGGGSD	ILF3	786	Q12906
SGGNSYGSGGASYNP	ILF3	816	Q12906
PGFSYGSGSTGSQQS	DVL1	556	O14640
PGFSYGSGSTGSQQS	DVL1P1	531	P54792
PGYHQSSYGGQSGST	SEC24C	21	P53992
GGYGGFQTSSSYTGS	FAM98A	421	Q8NCA5
SSQYGYGGSGGGSSA	SUPT6H	1586	Q7KZ85
SSSYGGAGGYTQSPG	RPA2	11	P15927
SGGSGSYSPGVTYSP	TMEM209	171	Q96SK2
SSFYSSSGGGGSTGN	ZCCHC14	741	Q8WYQ9
GYGGSSSSSSYGSGR	HNRNPA1	356	P09651