Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-18 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-10 ERVK-24	1.11e-16	37	76	10	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-18 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-10 ERVK-24	1.50e-16	38	76	10	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	3.17e-10	11	76	5	GO:0004523
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 USP14 THOP1 ERVK-8 ERVK-18 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-10 MMP8 ERVK-24 USP48	7.62e-10	430	76	14	GO:0004175
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.36e-09	14	76	5	GO:0003964
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.36e-08	21	76	5	GO:0035613
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 USP31 USP14 THOP1 ERVK-8 ERVK-18 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-10 MMP8 ERVK-24 USP48	2.04e-08	654	76	15	GO:0008233
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 ASAH2 ERVK-8 ERVK-5 ERVK-19 CHD4 ERVK-7 ERVK-21 ERVK-9 ERVK-10 MMP8 ERVK-24 ERVK-11 CBLB RBM20 ZFP37	1.89e-07	891	76	16	GO:0008270
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.77e-07	37	76	5	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	3.18e-07	38	76	5	GO:0034061
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	8.48e-07	46	76	5	GO:0016893
GeneOntologyMolecularFunction	structural molecule activity	MYBPH ERVK-6 POSTN IGF1R NPAP1 ERVK-8 ERVK-18 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-10 ERVK-24	1.09e-06	891	76	15	GO:0005198
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 ASAH2 ERVK-8 ERVK-5 ERVK-19 CHD4 ERVK-7 ERVK-21 ERVK-9 ERVK-10 MMP8 ERVK-24 ERVK-11 CBLB RBM20 ZFP37	8.24e-06	1189	76	16	GO:0046914
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.26e-05	79	76	5	GO:0004521
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 RBBP8 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.32e-05	136	76	6	GO:0004519
GeneOntologyMolecularFunction	translation elongation factor activity	EFL1 EEF1A1 EEF1A1P5	5.77e-05	20	76	3	GO:0003746
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 RBBP8 ERVK-8 CHD4 ERVK-7 ERVK-10 ERVK-11	6.25e-05	262	76	7	GO:0140097
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.71e-04	136	76	5	GO:0004540
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 RBBP8 ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.50e-04	231	76	6	GO:0004518
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	2.86e-04	152	76	5	GO:0016779
GeneOntologyMolecularFunction	translation factor activity, RNA binding	EFL1 EIF2B3 EEF1A1 EEF1A1P5	3.11e-04	85	76	4	GO:0008135
GeneOntologyMolecularFunction	translation regulator activity, nucleic acid binding	EFL1 EIF2B3 EEF1A1 EEF1A1P5	8.82e-04	112	76	4	GO:0090079
GeneOntologyMolecularFunction	insulin receptor substrate binding	IGF1R PIK3CA	1.45e-03	15	76	2	GO:0043560
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ERVK-6 MET IGF1R PIK3CA CAMK2A ERVK-8 ERVK-7 ERVK-10 ERVK-11 AURKB	2.86e-03	938	76	10	GO:0016772
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERVK-6 RBBP8 ERVK-8 CHD4 ERVK-7 ERVK-10 HARS1 ERVK-11	3.10e-03	645	76	8	GO:0140640
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	9.11e-10	13	79	5	GO:0015074
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11 AURKB	7.77e-07	83	79	6	GO:0006278
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.09e-06	48	79	5	GO:0000731
GeneOntologyBiologicalProcess	viral process	ERVK-6 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 EEF1A1	1.08e-05	464	79	10	GO:0016032
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.87e-05	85	79	5	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.87e-05	85	79	5	GO:0000768
GeneOntologyBiologicalProcess	syncytium formation	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	2.34e-05	89	79	5	GO:0006949
GeneOntologyBiologicalProcess	DNA-templated DNA replication	ERVK-6 RBBP8 ERVK-8 ERVK-7 ERVK-10 ERVK-11	6.26e-05	178	79	6	GO:0006261
GeneOntologyBiologicalProcess	DNA biosynthetic process	ERVK-6 ERVK-8 ERVK-7 ERVK-10 ERVK-11 AURKB	1.90e-04	218	79	6	GO:0071897
GeneOntologyBiologicalProcess	DNA replication	ERVK-6 MET RBBP8 ERVK-8 ERVK-7 ERVK-10 ERVK-11	1.93e-04	312	79	7	GO:0006260
Domain	G_TR_1	EFL1 EEF1A1	8.53e-04	13	63	2	PS00301
Domain	USP_CS	USP31 USP14 USP48	1.44e-03	66	63	3	IPR018200
Domain	EFTu-like_2	EFL1 EEF1A1	1.65e-03	18	63	2	IPR004161
Domain	GTP_EFTU_D2	EFL1 EEF1A1	1.65e-03	18	63	2	PF03144
Domain	G_TR_2	EFL1 EEF1A1	1.65e-03	18	63	2	PS51722
Domain	USP_1	USP31 USP14 USP48	1.70e-03	70	63	3	PS00972
Domain	UCH	USP31 USP14 USP48	1.78e-03	71	63	3	PF00443
Domain	USP_2	USP31 USP14 USP48	1.78e-03	71	63	3	PS00973
Domain	TF_GTP-bd_dom	EFL1 EEF1A1	1.85e-03	19	63	2	IPR000795
Domain	USP_3	USP31 USP14 USP48	1.85e-03	72	63	3	PS50235
Domain	USP_dom	USP31 USP14 USP48	1.85e-03	72	63	3	IPR028889
Domain	Peptidase_C19_UCH	USP31 USP14 USP48	1.85e-03	72	63	3	IPR001394
Domain	zf-CCHC	ERVK-6 ERVK-5	2.71e-03	23	63	2	PF00098
Domain	Transl_B-barrel	EFL1 EEF1A1	3.72e-03	27	63	2	IPR009000
Domain	ZF_CCHC	ERVK-6 ERVK-5	6.20e-03	35	63	2	PS50158
Domain	UBIQUITIN_1	USP14 USP48	6.91e-03	37	63	2	PS00299
Pathway	WP_MODULATION_OF_PI3KAKTMTOR_SIGNALING_BY_BIOACTIVE_SPHINGOLIPIDS	IGF1R PIK3CA ASAH2	1.49e-05	14	50	3	M45553
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2	MET CAMK2A GPRIN1 AURKB	7.15e-05	63	50	4	M27862
Pathway	BIOCARTA_HDAC_PATHWAY	IGF1R PIK3CA CAMK2A	1.03e-04	26	50	3	MM1371
Pathway	REACTOME_MET_ACTIVATES_PI3K_AKT_SIGNALING	MET PIK3CA	1.83e-04	6	50	2	M27741
Pathway	REACTOME_MET_ACTIVATES_PI3K_AKT_SIGNALING	MET PIK3CA	1.83e-04	6	50	2	MM15489
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-18 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-10 ERVK-24 ERVK-11	3.24e-18	94	79	12	21542922
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-18 ERVK-21 ERVK-25 ERVK-9 ERVK-10 ERVK-24 ERVK-11	7.41e-15	18	79	7	18664271
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-18 ERVK-19 ERVK-7 ERVK-21	5.32e-14	5	79	5	12629516
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10 ERVK-24	2.47e-11	4	79	4	10469592
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-5 ERVK-19 ERVK-10	2.47e-11	4	79	4	7983737
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	4.16e-11	12	79	5	14557543
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-18 ERVK-19	1.13e-08	3	79	3	10516026
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9 ERVK-11	1.13e-08	3	79	3	9971820
Pubmed	Activated cMET and IGF1R-driven PI3K signaling predicts poor survival in colorectal cancers independent of KRAS mutational status.	MET IGF1R PIK3CA	4.50e-08	4	79	3	25090459
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-5 ERVK-7	1.12e-07	5	79	3	11401426
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	2.24e-07	6	79	3	15063128
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	1.34e-06	10	79	3	12970426
Pubmed	Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474.	IGF1R PIK3CA	5.09e-06	2	79	2	25483727
Pubmed	Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells.	MET IGF1R	5.09e-06	2	79	2	16891453
Pubmed	Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer?	MET IGF1R	5.09e-06	2	79	2	21729677
Pubmed	IGF1R depletion facilitates MET-amplification as mechanism of acquired resistance to erlotinib in HCC827 NSCLC cells.	MET IGF1R	5.09e-06	2	79	2	28418902
Pubmed	Igf1r as a therapeutic target in a mouse model of basal-like breast cancer.	IGF1R EEF1A1	5.09e-06	2	79	2	19174523
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	5.09e-06	2	79	2	9060628
Pubmed	The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway.	IGF1R PIK3CA	5.09e-06	2	79	2	14597618
Pubmed	Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.	HIVEP2 CAMK2A	5.09e-06	2	79	2	23389689
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	5.09e-06	2	79	2	9460924
Pubmed	Copy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma.	MET PIK3CA	5.09e-06	2	79	2	26832731
Pubmed	Met, IGF1R, and other new targets in upper GI malignancies.	MET IGF1R	5.09e-06	2	79	2	23873272
Pubmed	Insulin-like growth factor-1 receptor is associated with better prognosis in classical Hodgkin's lymphoma: Correlation with MET expression.	MET IGF1R	5.09e-06	2	79	2	25916750
Pubmed	Circadian Gene Circuitry Predicts Hyperactive Behavior in a Mood Disorder Mouse Model.	HIVEP2 CAMK2A	5.09e-06	2	79	2	27028761
Pubmed	Overexpression of PI3K p110α contributes to acquired resistance to MET inhibitor, in MET-amplified SNU-5 gastric xenografts.	MET PIK3CA	5.09e-06	2	79	2	26543351
Pubmed	USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B.	USP48 AURKB	5.09e-06	2	79	2	34445214
Pubmed	Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.	ERVK-6 ERVK-18	5.09e-06	2	79	2	11672541
Pubmed	The MET/AXL/FGFR Inhibitor S49076 Impairs Aurora B Activity and Improves the Antitumor Efficacy of Radiotherapy.	MET AURKB	5.09e-06	2	79	2	28619752
Pubmed	Targeting Insulin-Like Growth Factor 1 Receptor Delays M-Phase Progression and Synergizes with Aurora B Inhibition to Suppress Cell Proliferation.	IGF1R AURKB	5.09e-06	2	79	2	32033461
Pubmed	Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment.	DIAPH3 AURKB	5.09e-06	2	79	2	21397845
Pubmed	The Deubiquitinating Enzyme USP14 Regulates Leukemic Chemotherapy Drugs-Induced Cell Apoptosis by Suppressing Ubiquitination of Aurora Kinase B.	USP14 AURKB	5.09e-06	2	79	2	28662510
Pubmed	Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders.	HIVEP2 CAMK2A	5.09e-06	2	79	2	30675529
Pubmed	Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.	AP2M1 PIK3CA CBLB	1.06e-05	19	79	3	31959764
Pubmed	Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma.	IGF1R PIK3CA	1.53e-05	3	79	2	22020193
Pubmed	Ligand-independent activation of MET through IGF-1/IGF-1R signaling.	MET IGF1R	1.53e-05	3	79	2	23526299
Pubmed	Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress.	MET IGF1R	1.53e-05	3	79	2	32978479
Pubmed	c-Met, epidermal growth factor receptor, and insulin-like growth factor-1 receptor are important for growth in uveal melanoma and independently contribute to migration and metastatic potential.	MET IGF1R	1.53e-05	3	79	2	22343486
Pubmed	MET in gastric cancer--discarding a 10% cutoff rule.	MET PIK3CA	1.53e-05	3	79	2	26033401
Pubmed	Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses.	ERVK-24 ERVK-11	1.53e-05	3	79	2	22067224
Pubmed	Expression patterns of aurora kinase B, heat shock protein 47, and periostin in esophageal squamous cell carcinoma.	POSTN AURKB	1.53e-05	3	79	2	20112500
Pubmed	CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4.	IGF1R CAMK2A	1.53e-05	3	79	2	29137928
Pubmed	Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins.	IGF1R PIK3CA	3.05e-05	4	79	2	9415396
Pubmed	CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells.	MET PIK3CA	3.05e-05	4	79	2	28258248
Pubmed	The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells.	MET RBBP8	3.05e-05	4	79	2	29855336
Pubmed	The impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer.	MET IGF1R	3.05e-05	4	79	2	28742836
Pubmed	Functional genetic approach identifies MET, HER3, IGF1R, INSR pathways as determinants of lapatinib unresponsiveness in HER2-positive gastric cancer.	MET IGF1R	3.05e-05	4	79	2	24973425
Pubmed	Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.	USP31 USP48	3.05e-05	4	79	2	16214042
Pubmed	Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer.	MET PIK3CA	3.05e-05	4	79	2	26334097
Pubmed	Correlation of clinicopathological parameters with HGF, c-Met, EGFR, and IGF-1R expression in uveal melanoma.	MET IGF1R	3.05e-05	4	79	2	20061986
Pubmed	Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis.	MET IGF1R	3.05e-05	4	79	2	18938767
Pubmed	Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL.	IGF1R PIK3CA	3.05e-05	4	79	2	21538027
Pubmed	Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.	USP14 AP2M1 PPP5C PIK3CA AGL DPYSL4 GPRIN1 EEF1A1	4.01e-05	558	79	8	35063084
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	USP31 MET STIM2 IGF1R PIK3CA GPRIN1 CBLB	4.96e-05	421	79	7	36976175
Pubmed	PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer.	IGF1R PIK3CA	5.07e-05	5	79	2	28292957
Pubmed	Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.	PIK3CA CBLB	5.07e-05	5	79	2	11526404
Pubmed	Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition.	IGF1R PIK3CA	5.07e-05	5	79	2	27048245
Pubmed	Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways.	MET PIK3CA	5.07e-05	5	79	2	17682062
Pubmed	Somatic mutation of epidermal growth factor receptor in a small subset of cutaneous squamous cell carcinoma.	MET IGF1R	7.60e-05	6	79	2	19812598
Pubmed	Molecular characterization of oral squamous cell carcinoma using targeted next-generation sequencing.	MET PIK3CA	7.60e-05	6	79	2	26173098
Pubmed	Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks.	MET IGF1R	7.60e-05	6	79	2	23861540
Pubmed	Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation.	IGF1R PIK3CA	1.06e-04	7	79	2	12904469
Pubmed	The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family.	MET IGF1R	1.06e-04	7	79	2	2482828
Pubmed	Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.	PIK3CA CBLB	1.06e-04	7	79	2	27474268
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CEP68 STIM2 AP2M1 ACSS1 KCNS2 MBD5 CCSER1	1.33e-04	493	79	7	15368895
Pubmed	Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95.	CAMK2A EEF1A1	1.41e-04	8	79	2	23260144
Pubmed	ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.	STIM2 RYR3	1.41e-04	8	79	2	30563862
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	USP31 STIM2 IGF1R HIVEP2 CAMK2A CC2D1A EEF1A1 AHNAK2 CCSER1	1.47e-04	861	79	9	36931259
Pubmed	Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome.	USP14 EEF1A1	1.82e-04	9	79	2	19349277
Pubmed	Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells.	MET IGF1R	1.82e-04	9	79	2	24285539
Pubmed	Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells.	IGF1R PIK3CA	2.27e-04	10	79	2	24051437
Pubmed	A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.	MET IGF1R	2.76e-04	11	79	2	8247543
Pubmed	Lineage-specific responses to reduced embryonic Pax3 expression levels.	POSTN MET	2.76e-04	11	79	2	18243171
Pubmed	Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.	MET AP2M1 PIK3CA EEF1A1 EEF1A1P5	3.00e-04	256	79	5	24189400
Pubmed	Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.	PPP5C CAMK2A	3.31e-04	12	79	2	12435421
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	AP2M1 PIK3CA CBLB EEF1A1 EEF1A1P5	3.58e-04	266	79	5	19380743
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP31 USP14 CHD4 USP48	3.60e-04	147	79	4	29576527
Pubmed	The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.	MYBPH UCP3 CHD4	3.69e-04	61	79	3	27166947
Pubmed	Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex.	HARS1 EEF1A1	3.91e-04	13	79	2	11829477
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	PPP5C HARS1 CCDC136 CCSER1	3.98e-04	151	79	4	17043677
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	USP14 EFL1 THOP1 PPP5C AGL EIF2B3 HARS1 ATE1 USP48 EEF1A1 AHNAK2	4.39e-04	1455	79	11	22863883
Pubmed	Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.	MYBPH THOP1 PIK3CA EEF1A1	4.40e-04	155	79	4	22673621
Pubmed	A molecular dissection of the repression circuitry of Ikaros.	RBBP8 CHD4	4.55e-04	14	79	2	12015313
Pubmed	Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation.	SMC1B AURKB	4.55e-04	14	79	2	21875947
Pubmed	The DNA sequence and biology of human chromosome 19.	ERVK-6 THOP1 PPP5C ERVK-19 LYL1	4.82e-04	284	79	5	15057824
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	USP14 AP2M1 THOP1 CHD4 HARS1 HYDIN EEF1A1 AHNAK2	4.96e-04	807	79	8	30575818
Pubmed	Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.	AP2M1 PIK3CA EIF2B3	5.08e-04	68	79	3	25754235
Pubmed	Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3.	EEF1A1 EEF1A1P5	5.25e-04	15	79	2	8812466
Pubmed	TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.	CHD4 EEF1A1	5.25e-04	15	79	2	19321449
Pubmed	Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.	HIVEP2 ACSS1 EEF1A1	5.31e-04	69	79	3	32238831
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	MET IGF1R PIK3CA	5.77e-04	71	79	3	28319113
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP14 USP48	6.78e-04	17	79	2	23287719
Pubmed	Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.	POSTN MMP8	6.78e-04	17	79	2	27398409
Pubmed	LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.	CHD4 LYL1	7.61e-04	18	79	2	19497860
Pubmed	The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.	MET IGF1R PIK3CA	8.17e-04	80	79	3	28205554
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP31 USP14 USP48	8.47e-04	81	79	3	12838346
Pubmed	Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.	POSTN EZH1	9.43e-04	20	79	2	22267199
Pubmed	CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.	MET IGF1R	1.04e-03	21	79	2	22154806
Pubmed	Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.	CHD4 USP48 EEF1A1	1.04e-03	87	79	3	24169447
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	MET STIM2 GBP6 AP2M1 IGF1R CHD4 CBLB AURKB	1.08e-03	910	79	8	36736316
GeneFamily	Ubiquitin specific peptidases	USP31 USP14 USP48	2.56e-04	56	40	3	366
GeneFamily	CTAGE family	CTAGE15 CTAGE6	4.92e-04	15	40	2	907
Coexpression	GSE21927_BALBC_VS_C57BL6_MONOCYTE_TUMOR_DN	USP14 HIVEP2 AGL EIF2B3 AIDA SMC1B	9.28e-06	193	66	6	M7575
ToppCell	(3)_Chondrocytes-(30)_Chondro\|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis	MYBPH GPR182 WFIKKN2 CHSY1 PRR7 EEF1A1	4.92e-07	195	67	6	f5597d3ed37770c6fa2b339f98a80ac7ecd4f9ff
ToppCell	LPS-antiTNF-Endothelial-Epi-like-Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND5B THOP1 RBBP8 CAMK2A HARS1	3.94e-06	157	67	5	abfd05ed993b80822739f47a735f154092a23632
ToppCell	COVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DENND5B PPCDC DIAPH3 USP48 AURKB	9.45e-06	188	67	5	567b08514d9d84cbb40f9b7a679eec304f023428
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDNF CAMK2A ACSS1 RBM20 RYR3	9.70e-06	189	67	5	e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDNF CAMK2A ACSS1 RBM20 RYR3	9.70e-06	189	67	5	b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MET RBBP8 DIAPH3 HYDIN CCSER1	9.95e-06	190	67	5	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	POSTN NDNF IGF1R MBD5 CBLB	9.95e-06	190	67	5	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MET RBBP8 DIAPH3 HYDIN CCSER1	1.10e-05	194	67	5	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	Transverse-T_cell-cycling_gd_T\|Transverse / Region, Cell class and subclass	DPYSL4 DIAPH3 GPRIN1 SMC1B AURKB	1.21e-05	198	67	5	5131b0b7d6c4dd8872cef9f2e233f59f751b4690
ToppCell	Transverse-(1)_T_cell-(18)_cycling_gd_T\|Transverse / shred on region, Cell_type, and subtype	DPYSL4 DIAPH3 GPRIN1 SMC1B AURKB	1.21e-05	198	67	5	396dddf7ebad41c3a91329b6a280623c0dfdcd2f
ToppCell	LPS-antiTNF-Unknown-Endothelial-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	POSTN DIAPH3 RYR3 AURKB	4.70e-05	132	67	4	02491930097b75aaeedab9e8200711b0dc610944
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	POSTN DIAPH3 CCDC136 RYR3	4.70e-05	132	67	4	46c80eab16a70da9f363a9fbdf50bccab0b287d7
ToppCell	LPS-IL1RA+antiTNF-Unknown\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	POSTN DIAPH3 CCDC136 RYR3	4.70e-05	132	67	4	a022c3c41654166cb106f27dc54fa88e8c40f898
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Slco2a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MET ASAH2 DIAPH3 RYR3	4.84e-05	133	67	4	9d7a08170d38ae9b2ff10a0fa505aeb3aae2824d
Disease	gastrinoma (is_marker_for)	MET IGF1R	1.34e-05	3	63	2	DOID:5577 (is_marker_for)
Disease	developmental and epileptic encephalopathy 33 (implicated_via_orthology)	EEF1A1 EEF1A1P5	1.34e-05	3	63	2	DOID:0080463 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	STIM2 PPCDC EEF1A1 EEF1A1P5	2.64e-05	80	63	4	DOID:12930 (implicated_via_orthology)
Disease	HEPATOCELLULAR CARCINOMA	MET PIK3CA	1.60e-04	9	63	2	114550
Disease	Hepatocellular carcinoma	MET PIK3CA	1.60e-04	9	63	2	cv:C2239176
Disease	melanoma	MET PIK3CA ECHDC1 NPAP1 MMP8	1.90e-04	248	63	5	C0025202
Disease	abdominal aortic aneurysm (is_marker_for)	POSTN MMP8	2.00e-04	10	63	2	DOID:7693 (is_marker_for)
Disease	Paroxysmal atrial fibrillation	CEP68 IGF1R MBD5 RBM20	3.51e-04	156	63	4	C0235480
Disease	familial atrial fibrillation	CEP68 IGF1R MBD5 RBM20	3.51e-04	156	63	4	C3468561
Disease	Persistent atrial fibrillation	CEP68 IGF1R MBD5 RBM20	3.51e-04	156	63	4	C2585653
Disease	Atrial Fibrillation	CEP68 IGF1R MBD5 RBM20	3.87e-04	160	63	4	C0004238
Disease	Benign neoplasm of stomach	MET PIK3CA	5.98e-04	17	63	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	MET PIK3CA	5.98e-04	17	63	2	C0496905
Disease	Carcinoma in situ of stomach	MET PIK3CA	5.98e-04	17	63	2	C0154060
Disease	hepatocellular carcinoma (is_implicated_in)	MET IGF1R PIK3CA RYR3	6.15e-04	181	63	4	DOID:684 (is_implicated_in)
Disease	periodontitis (biomarker_via_orthology)	POSTN MET	9.18e-04	21	63	2	DOID:824 (biomarker_via_orthology)
Disease	Stomach Carcinoma	MET PIK3CA	9.18e-04	21	63	2	C0699791
Disease	cerebrospinal fluid biomarker measurement	POSTN ASAH2 WFIKKN2	1.15e-03	96	63	3	EFO_0006794
Disease	atrial fibrillation	CEP68 IGF1R MBD5 RBM20 CCDC136	1.18e-03	371	63	5	EFO_0000275
Disease	Neoplasm of the genitourinary tract	MET PIK3CA	1.20e-03	24	63	2	cv:C0042065
Disease	breast cancer (implicated_via_orthology)	MET PIK3CA	1.30e-03	25	63	2	DOID:1612 (implicated_via_orthology)
Disease	colon adenocarcinoma (is_implicated_in)	PIK3CA CHD4	1.41e-03	26	63	2	DOID:234 (is_implicated_in)
Disease	congestive heart failure (biomarker_via_orthology)	RNLS UCP3 MMP8	1.57e-03	107	63	3	DOID:6000 (biomarker_via_orthology)
Disease	chronic kidney disease	RNLS AGL DIAPH3 CCSER1	1.62e-03	235	63	4	EFO_0003884
Disease	hyperthyroidism (biomarker_via_orthology)	IGF1R UCP3	1.64e-03	28	63	2	DOID:7998 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MAKEDPVCAPESMGS	ACSS1	271	Q9NUB1
PVCAPESMGSEDMLF	ACSS1	276	Q9NUB1
TDDRCPAKPEEEGMM	ERVK-18	26	O42043
CPAKPEEEGMMINIS	ERVK-19	141	O71037
CPAKPEEEGMMINIS	ERVK-8	141	Q902F8
CPAKPEEEGMMINIS	ERVK-9	141	Q9UKH3
VEQDCKMMFPPPGQS	CTAGE6	601	Q86UF2
VEQDCKMMFPPPGQS	CTAGE15	601	A4D2H0
MNGDCVMDKPLDLSD	RBBP8	481	Q99708
AGCTLIPDKKPMAAM	CEP68	736	Q76N32
PMCEEPLMGVCFVLE	EFL1	881	Q7Z2Z2
KCFAFMEMDEIKPGP	AIDA	256	Q96BJ3
PVPFKDIMKDECSML	CCSER1	666	Q9C0I3
DCSAAPLEMMENFPK	DIAPH3	101	Q9NSV4
MSPSLFLPAMKEGCN	IQCA1	386	Q86XH1
PPEANGVIMMLKSCD	CACUL1	81	Q86Y37
ETLDMMKKPRCGVPD	MMP8	81	P22894
CPSDMDVEMPGLNLD	RBM20	991	Q5T481
KSLGTPEDGMAVCMF	ECHDC1	121	Q9NTX5
PSMCIAKGPGQDMFD	ASAH2	381	Q9NR71
CSIIDPFGMPMLDLD	CBLB	436	Q13191
LCPGTMEEKPMCEKT	IGF1R	181	P08069
MEGGLLDKPDNCPDM	IGF1R	1226	P08069
LDKPDNCPDMLFELM	IGF1R	1231	P08069
EMMLLPDCCYSDDGP	FAM214A	91	Q32MH5
AMRSCDFGDGMKEVP	KCNS2	426	Q9ULS6
SDPMLEGCRMYKPLA	LMLN2	476	A0A1B0GTW7
LSADDAFMMAPKPGL	NDNF	231	Q8TB73
MESGPKMLAPVCLVE	GBP6	1	Q6ZN66
LSGMPECKFGMNDKI	AP2M1	206	Q96CW1
CPAKPEEEGMMINIS	ERVK-7	901	P63135
IGMPVCEFDMVKDPE	PIK3CA	121	P42336
DMSKPPCYEEAVLMA	PRR7	146	Q8TB68
LQMPVLGMTPADDFC	DPYSL4	76	O14531
MKPDIVCIPDDADMG	EIF2B3	71	Q9NR50
RVPPFSEEVFMECMG	HYDIN	4496	Q4G0P3
TDDRCPAKPEEEGMM	ERVK-24	26	P61566
CPAKPEEEGMMINIS	ERVK-25	141	P61570
CPAKPEEEGMMINIS	ERVK-6	141	Q69384
IDDRCPAKPEEEGMM	ERVK-7	26	P61567
IVDMVPGKPMCVESF	EEF1A1	401	P68104
GPLPMEAIEKMASLC	CC2D1A	66	Q6P1N0
PFDQDAVNMLCMPKG	DENND5B	71	Q6ZUT9
IDDRCPAKPEEEGMM	ERVK-21	136	P61565
TDDRCPAKPEEEGMM	ERVK-5	26	Q9HDB8
GPTMTEKAEMVCAPS	LYL1	11	P12980
MPECKNPFKLMIGSS	MBD5	161	Q9P267
VPKGSCEDEPMDSTM	ATE1	106	O95260
IVDMVPGKPMCVESF	EEF1A1P5	401	Q5VTE0
CPAKPEEEGMMINIS	HERVK_113	141	Q902F9
VDPVSLGKMDPMCSG	GPRIN1	416	Q7Z2K8
AYHMVCLDPDMEKAP	CHD4	391	Q14839
NFDPMIPDAECLKIM	HARS1	181	P12081
PDSAEPMDRSAMCAF	MET	351	P08581
MAMAEGERTECAEPP	PPP5C	1	P53041
EGPEPMCLFMAPFET	GPR182	196	O15218
GSGPPRQFMDCMADK	SPATA31E1	1301	Q6ZUB1
MMEKNTSEGPACSPE	MYBPH	1	Q13203
KMCDPGMTAFEPEAL	CAMK2A	371	Q9UQM7
DTKAPMMPLSCFLGN	PHAF1	181	Q9BSU1
LMSGKRMPDEKPFCI	NPAP1	296	Q9NZP6
ACSEPSMQMPKVGFA	AHNAK2	4751	Q8IVF2
EFKECMECLEKPMAP	CCDC136	901	Q96JN2
EMGKLALEPGENFCM	CHSY1	206	Q86X52
MEPKASCPAAAPLME	PPCDC	1	Q96CD2
KTMCGTLDYLPPEMI	AURKB	231	Q96GD4
MDDPRYGMCPLKGAS	ZNF100	1	Q8IYN0
PLDCMIKMVAQEGPT	UCP3	256	P55916
SPIEGMVMKEGDCNF	RNLS	91	Q5VYX0
CVAPGKRFMPMDNLS	SMC1B	1111	Q8NDV3
AAGDSPALMTDPCMS	STIM2	41	Q9P246
PDMAANFCPDHKAPM	RYR3	2351	Q15413
ASMFPENGVPDDMKE	EZH1	241	Q92800
CPAKPEEEGMMINIS	ERVK-10	901	P10266
CPAKPEEEGMMINIS	ERVK-11	901	Q9UQG0
MPQKSDNGEVECSMP	ZNF484	821	Q5JVG2
DSGMPKDRFSAEMPD	TRBV12-5	76	A0A1B0GX78
ETDMMPEGPSFPVCS	USP31	261	Q70CQ4
MEGMKGCPAVLPIDH	POSTN	86	Q15063
MMGSADALPEEPSAK	USP14	71	P54578
LDIPSCMDEECMLPS	HIVEP2	2016	P31629
MKPPAACAGDMADAA	THOP1	1	P52888
DVMQVCMPEEGFKGT	USP48	1016	Q86UV5
MGCQAPKPDMISKLE	ZFP37	71	Q9Y6Q3
EPAMRKDDVCPGMKC	TXNRD3NB	116	Q6F5E7
GPVGMPKEATCDHFM	WFIKKN2	101	Q8TEU8
PLGMKTLDPDDMVYC	AGL	1411	P35573