Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

CTNND1 RRBP1 UBR5 ERC1 TNS3

6.56e-0720928536779422
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

MRTFB ALPK1 RRBP1 UBR5 ERC1

9.44e-0722528512168954
Pubmed

Increased androgen receptor levels and signaling in ovarian cancer cells by VEPH1 associated with suppression of SMAD3 and AKT activation.

SMAD3 VEPH1

1.87e-06328231614206
Pubmed

Myocardin-like protein 2 regulates TGFβ signaling in embryonic stem cells and the developing vasculature.

MRTFB SMAD3

1.74e-05828222899851
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

CTNND1 RRBP1 UBR5 PRDM15 MEF2D SMAD3

5.21e-0585728625609649
Pubmed

Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins.

CTNND1 MEF2D

6.52e-051528218541383
Pubmed

Betaglycan is required for the establishment of nephron endowment in the mouse.

EYA1 SMAD3

6.52e-051528221533152
Pubmed

Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling.

EYA1 SMAD3

8.44e-051728223895934
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

ADNP2 UBR5 ZNF507

1.11e-0411628330804394
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

MRTFB ALPK1 CTNND1 UBR5 MEF2D TNS3

1.49e-04103828626673895
Pubmed

Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression.

MRTFB SMAD3

1.85e-042528220019329
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

MRTFB UBR5 ERC1 ZNF507

3.35e-0441828434709266
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ALPK1 CTNND1 ERC1 MEF2D TNS3

5.63e-0486128536931259
Pubmed

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.

MRTFB CTNND1 ERC1

6.90e-0421628331519766
Pubmed

PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome.

MRTFB ERC1

7.18e-044928231762063
Pubmed

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.

SLC30A3 ERC1 SMAD3

7.18e-0421928329997244
InteractionGSK3B interactions

EYA1 CTNND1 RRBP1 TSKS UBR5 ERC1 TNS3 SMAD3

1.65e-05868288int:GSK3B
Cytoband7p22.1

RSPH10B2 RSPH10B

3.81e-04472827p22.1
Cytoband2p23.3

TRIM54 SLC30A3

7.97e-04682822p23.3
CytobandEnsembl 112 genes in cytogenetic band chr7p22

RSPH10B2 RSPH10B

3.04e-03134282chr7p22
CytobandEnsembl 112 genes in cytogenetic band chr2p23

TRIM54 SLC30A3

3.74e-03149282chr2p23
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ADNP2 PRDM15 ZNF507

2.80e-0271817328
ToppCellfacs-Heart-LA-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS8 SLC30A3 VEPH1

1.82e-041772831b153fbfe1323dc589de4af73a52149ea5ce6763
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRIM54 CTNND1 SLC30A3

1.82e-04177283f902600c639087664316b3cf30cab243bc3d1c5c
ToppCellfacs-Heart-LA-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS8 SLC30A3 VEPH1

1.82e-0417728332fecefba1a55e1f418c9a055236fa11175c692d
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BEX3 EYA1 VEPH1

1.82e-04177283a68c3688f12aee22f3cb4049c4bccacbacb0fae6
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

EYA1 TNS3 VEPH1

1.82e-041772839af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRIM54 TRPA1 SLC30A3

1.85e-04178283731e1e8eff2c4018c75dfc66632a316010a09a9a
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

EYA1 TNS3 VEPH1

1.89e-0417928304ce3673e46606f63d9c87bcba3a64c96817d812
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

EYA1 TNS3 VEPH1

1.95e-04181283b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRIM54 MRTFB SLC30A3

1.98e-0418228314a117c5e50db31ee1b2cf4df4d133451fd6d55f
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EYA1 SLC30A3 VEPH1

2.01e-0418328338a54216458ad57f356bb4ddf272e1af8036ddeb
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EYA1 SLC30A3 VEPH1

2.01e-04183283764ea07621f77fbd13a877aed5806ae2b3dfb43e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRIM54 MRTFB SLC30A3

2.11e-04186283bdbe290f81106a53c8c30a92fbb385597c62b2ac
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRIM54 MRTFB SLC30A3

2.14e-04187283f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UBR5 ERC1 SMAD3

2.18e-041882839cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____podocyte-2|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAG1 TNS3 VEPH1

2.18e-04188283c300accbac71a3bc075fe985543d8a8ead82531b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRIM54 MRTFB SLC30A3

2.18e-0418828350c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UBR5 ERC1 SMAD3

2.18e-041882836468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UBR5 ERC1 SMAD3

2.18e-041882837a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell3'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRIM54 ALPK1 TRPA1

2.21e-041892837dad62bd50c197838058e89abd0ee387de3e83cd
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAG1 TNS3 CERS3

2.21e-04189283319e42f6e2322208de78bc666fb2c074707eb4da
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAG1 TNS3 CERS3

2.25e-04190283050d6e0546954675b6adbfecb67854b1e09739d1
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MRTFB CTNND1 ERC1

2.39e-041942830b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell(1)_T_cells-(1)_T_CD4_naive|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

BEX3 TRMT13 ERC1

2.42e-04195283d3fa551bc6f5ee5890af1040415e61ecd5d46201
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ADAMTS8 ALPK1 RRBP1

2.50e-04197283fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCellmild-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

EIF2AK4 RRBP1 MEF2D

2.50e-041972830cb00daa6943f7a7fb34a8fdf51188646af65686
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

EYA1 TNS3 VEPH1

2.54e-04198283b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellControl_saline|World / Treatment groups by lineage, cell group, cell type

BEX3 CTNND1 VEPH1

2.57e-0419928311c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

BEX3 RRBP1 VEPH1

2.61e-04200283c89f3cb36bb14c476d6a392bfd3ded1c8feecfeb
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MRTFB CTNND1 UBR5

2.61e-04200283dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

ADAMTS8 ALPK1 RRBP1

2.61e-04200283a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellNeuronal-Excitatory|Neuronal / cells hierarchy compared to all cells using T-Statistic

MRTFB SLC30A3 SMAD3

2.61e-042002834409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Intermediate|10w / Sample Type, Dataset, Time_group, and Cell type.

ADAMTS8 ALPK1 TNS3

2.61e-04200283e5a8647c47a49c8c90c78d681193946de103d8ff
Drugirinotecan HCl; Down 200; 100uM; PC3; HT_HG-U133A

MRTFB UBR5 ERC1 TNS3 SMAD3

1.93e-061712857535_DN
Diseasepolyp of colon

TNS3 SMAD3

1.12e-0356262MONDO_0021400
Diseaseautoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis

DAG1 SMAD3

1.74e-0370262EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
DiseaseCorneal astigmatism

ADAMTS8 SMAD3

2.10e-0377262EFO_1002040
Diseasecentral corneal thickness

ADAMTS8 SMAD3 CERS3

2.47e-03309263EFO_0005213
Diseasemean corpuscular hemoglobin concentration

DAG1 TRIM54 EIF2AK4 UBR5 TNS3

2.49e-031105265EFO_0004528
DiseaseS-warfarin measurement

EIF2AK4 ERC1

3.30e-0397262EFO_0803323
Diseasemigraine disorder

EYA1 RRBP1 MEF2D

3.71e-03357263MONDO_0005277
Diseasecorneal topography

EIF2AK4 SMAD3

4.15e-03109262EFO_0004345

Protein segments in the cluster

PeptideGeneStartEntry
MEESELHEVLHHTLT

EIF2AK4

1006

Q9P2K8
ELSNHHDHHDEFCLM

BEX3

96

Q00994
LAHELGHVLSMPHDD

ADAMTS8

361

Q9UP79
RAMHSLHSQLHDLSL

ALPK1

636

Q96QP1
VSEEELIHHLLMHGL

ADNP2

756

Q6IQ32
LAEAEMHVHHLESLL

ERC1

336

Q8IUD2
HTFDNMLHLHSLSLE

LRRC9

971

Q6ZRR7
FHHHKLTLADMDRIL

RSPH10B

456

P0C881
FHHHKLTLADMDRIL

RSPH10B2

456

B2RC85
LEASMHSVLSDLHEA

DAG1

46

Q14118
SHSDLMALHHALELE

EYA1

576

Q99502
LANMEHSFHHILLLE

VEPH1

316

Q14D04
NDLLSHSGMLDHSHS

MRTFB

1006

Q9ULH7
HSDIVMATLHELLHA

LMLN2

296

A0A1B0GTW7
LAHIIHHLAAISLMS

CERS3

206

Q8IU89
SHDSIKMEIVDHALH

CTNND1

481

O60716
LMHHLTEDHLDLNNA

MEF2D

281

Q14814
TLKDHIMSHPALHDA

TRMT13

136

Q9NUP7
DHIHVHFKDIALMDD

PRDM15

946

P57071
DILDDEMPHHDLHSV

TNS3

476

Q68CZ2
LHSKAEQHLMCEEHE

TRIM54

116

Q9BYV2
TMLHRASLFDHHELA

TRPA1

311

O75762
EHTSHLEAELEKHMA

RRBP1

1196

Q9P2E9
DLHSHHELRAMELCE

SMAD3

96

P84022
TLDHLHLKMCSLHDH

TSKS

546

Q9UJT2
HAVDAHLLHASALDL

nan

56

Q5BKY6
LAHSLAIMTDAAHLL

SLC30A3

96

Q99726
HIADNSKDLESHMIH

ZNF507

676

Q8TCN5
EDLMSLLDADIHSAH

UBR5

246

O95071
RLHHFNSSHLEIDDM

MYORG

341

Q6NSJ0