Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNHD1 DNAH14 DNAH6	8.60e-05	18	97	3	GO:0008569
GeneOntologyCellularComponent	3M complex	CUL7 ANKRA2	2.11e-04	5	97	2	GO:1990393
GeneOntologyCellularComponent	eukaryotic translation initiation factor 2 complex	EIF2S3B EIF2S3	3.16e-04	6	97	2	GO:0005850
Domain	Leu-rich_rpt	LGR4 LRRC4C OMG LRIG2 NOD1 LRRIQ1 LRRC25 TLR4 CD180 LRRC18 GP1BA	1.45e-07	271	96	11	IPR001611
Domain	Leu-rich_rpt_typical-subtyp	LGR4 LRRC4C OMG LRIG2 LRRIQ1 TLR4 CD180 LRRC18 GP1BA	3.21e-07	177	96	9	IPR003591
Domain	LRR_TYP	LGR4 LRRC4C OMG LRIG2 LRRIQ1 TLR4 CD180 LRRC18 GP1BA	3.21e-07	177	96	9	SM00369
Domain	-	LGR4 LRRC4C OMG LRIG2 NOD1 LRRIQ1 LRRC25 TLR4 CD180 LRRC18 GP1BA	7.83e-07	321	96	11	3.80.10.10
Domain	LRR	LGR4 LRRC4C OMG LRIG2 LRRIQ1 TLR4 CD180 LRRC18 GP1BA	9.36e-07	201	96	9	PS51450
Domain	L_dom-like	LGR4 LRRC4C OMG LRIG2 NOD1 LRRIQ1 LRRC25 TLR4 CD180 LRRC18 GP1BA	9.68e-07	328	96	11	IPR032675
Domain	LRR_8	LGR4 LRRC4C OMG LRIG2 TLR4 CD180 LRRC18 GP1BA	2.80e-06	171	96	8	PF13855
Domain	LRR_1	LGR4 LRRC4C OMG LRIG2 LRRIQ1 TLR4 CD180 LRRC18	1.72e-05	219	96	8	PF00560
Domain	Dynein_HC_stalk	DNHD1 DNAH14 DNAH6	4.60e-05	14	96	3	IPR024743
Domain	MT	DNHD1 DNAH14 DNAH6	4.60e-05	14	96	3	PF12777
Domain	DHC_fam	DNHD1 DNAH14 DNAH6	5.73e-05	15	96	3	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH14 DNAH6	5.73e-05	15	96	3	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH14 DNAH6	5.73e-05	15	96	3	PF03028
Domain	Cys-rich_flank_reg_C	LRRC4C LRIG2 TLR4 CD180 GP1BA	1.01e-04	90	96	5	IPR000483
Domain	LRRCT	LRRC4C LRIG2 TLR4 CD180 GP1BA	1.01e-04	90	96	5	SM00082
Domain	LRRNT	LGR4 LRRC4C OMG GP1BA	1.58e-04	53	96	4	PF01462
Domain	LRRCT	LRIG2 TLR4 CD180	5.86e-04	32	96	3	PF01463
Domain	U-box	UBE4B RBBP6	7.17e-04	8	96	2	PF04564
Domain	DNA/RNA_helicase_DEAH_CS	EP400 CHD1 DHX30	7.64e-04	35	96	3	IPR002464
Domain	DEAH_ATP_HELICASE	EP400 CHD1 DHX30	9.74e-04	38	96	3	PS00690
Domain	Ubox_domain	UBE4B RBBP6	1.15e-03	10	96	2	IPR003613
Domain	P-loop_NTPase	MPP3 DNHD1 EP400 CHD1 DNAH14 GFM2 DHX30 NOD1 LRRIQ1 EIF2S3 NAV2 DNAH6	1.33e-03	848	96	12	IPR027417
Domain	-	MPP3 DNHD1 EP400 CHD1 DNAH14 GFM2 DHX30 NOD1 EIF2S3 NAV2 DNAH6	1.54e-03	746	96	11	3.40.50.300
Domain	LRRNT	LGR4 LRRC4C OMG GP1BA	1.64e-03	98	96	4	IPR000372
Domain	LRRNT	LGR4 LRRC4C OMG GP1BA	1.64e-03	98	96	4	SM00013
Domain	ARM-type_fold	MROH5 CUL7 MEI1 TEX10 ARMC2 INF2 ULK4	1.83e-03	339	96	7	IPR016024
Domain	Dynein_heavy_chain_D4_dom	DNAH14 DNAH6	2.29e-03	14	96	2	IPR024317
Domain	Dynein_heavy_dom-2	DNHD1 DNAH6	2.29e-03	14	96	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH6	2.29e-03	14	96	2	PF08393
Domain	AAA_8	DNAH14 DNAH6	2.29e-03	14	96	2	PF12780
Domain	ARM-like	MROH5 CUL7 MEI1 TEX10 ARMC2 ULK4	2.70e-03	270	96	6	IPR011989
Domain	Rib_L2_dom2	CUL7 TP53BP1	3.79e-03	18	96	2	IPR014722
Domain	-	CUL7 TP53BP1	3.79e-03	18	96	2	2.30.30.30
Domain	EFTu-like_2	GFM2 EIF2S3	3.79e-03	18	96	2	IPR004161
Domain	GTP_EFTU_D2	GFM2 EIF2S3	3.79e-03	18	96	2	PF03144
Domain	G_TR_2	GFM2 EIF2S3	3.79e-03	18	96	2	PS51722
Domain	TF_GTP-bd_dom	GFM2 EIF2S3	4.22e-03	19	96	2	IPR000795
Domain	BRCT	TOPBP1 TP53BP1	4.22e-03	19	96	2	PF00533
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CENPT EP400 RBBP6 NOL6 TOPBP1 EIF2S3B CHD1 MED19 EIF2S3 SENP6 KMT2A PCBP2 CUX1 TP53BP1 KNL1	9.70e-08	954	100	15	36373674
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	EP400 TOPBP1 CHD1 ARHGAP11A TEX10 DHX30 SENP6 ZNF518B	2.73e-07	222	100	8	37071664
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EP400 TTC28 UBE4B SMURF1 TNRC6B LRRC4C DHX30 UBR5 PDE4DIP DISP2	2.93e-07	407	100	10	12693553
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MPP3 SEMA6C EP400 PCNX3 UBE4B OBSCN DHX30 INF2 CCDC34 NAV2 ULK4 DISP2 ESPL1 TTC38 IL4R	6.28e-07	1105	100	15	35748872
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	EP400 TTC28 RBBP6 TOPBP1 E2F3 CUL7 UBR5 SENP6 PCBP2 TP53BP1 KNL1	1.07e-06	588	100	11	38580884
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EP400 PCNX3 RBBP6 NOL6 TOPBP1 TNRC6B CHD1 TEX10 DHX30 MED19 UTS2 EIF2S3 SEC24B KMT2A EXOC2 CNOT2 EPB41L2	1.23e-06	1497	100	17	31527615
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EP400 RBBP6 TNRC6B CHD1 DHX30 EIF2S3 SEC24B SENP6 KMT2A PCBP2 EPB41L2 TP53BP1 KNL1	2.87e-06	934	100	13	33916271
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	EP400 UBE4B RBBP6 NOL6 CHD1 KMT2A CNOT2 TP53BP1	6.69e-06	341	100	8	32971831
Pubmed	TLR accessory molecule RP105 (CD180) is involved in post-interventional vascular remodeling and soluble RP105 modulates neointima formation.	TLR4 CD180	8.18e-06	2	100	2	23844130
Pubmed	Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.	TLR4 CD180	8.18e-06	2	100	2	15852007
Pubmed	Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation.	TLR4 TREM2	8.18e-06	2	100	2	30756214
Pubmed	Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression.	NOD1 TLR4	8.18e-06	2	100	2	28536249
Pubmed	Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation.	NOD1 TLR4	8.18e-06	2	100	2	26915562
Pubmed	Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14).	KMT2A KNL1	8.18e-06	2	100	2	12618768
Pubmed	Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30.	DHX30 PCBP2	8.18e-06	2	100	2	32234473
Pubmed	Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling.	NOD1 TLR4	8.18e-06	2	100	2	24882704
Pubmed	Triggering receptor expressed on myeloid cells 2 activation downregulates toll-like receptor 4 expression and ameliorates cognitive impairment in the Aβ1-42 -induced Alzheimer's disease mouse model.	TLR4 TREM2	8.18e-06	2	100	2	32412103
Pubmed	TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation.	TLR4 TREM2	8.18e-06	2	100	2	27934908
Pubmed	Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.	TOPBP1 TP53BP1	8.18e-06	2	100	2	31135337
Pubmed	Association Between Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Genetic Variants and Clinical Progression of Huntington's Disease.	TLR4 TREM2	8.18e-06	2	100	2	31724242
Pubmed	Involvement of ILR4α and TLR4 in miscarriages.	TLR4 IL4R	8.18e-06	2	100	2	30639993
Pubmed	Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells.	TLR4 TREM2	8.18e-06	2	100	2	31590042
Pubmed	Histone Methylation Directs Myeloid TLR4 Expression and Regulates Wound Healing following Cutaneous Tissue Injury.	TLR4 KMT2A	8.18e-06	2	100	2	30710046
Pubmed	A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses.	NOD1 TLR4	8.18e-06	2	100	2	22870324
Pubmed	RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice.	TLR4 CD180	8.18e-06	2	100	2	25156852
Pubmed	Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain.	EIF2S3B EIF2S3	8.18e-06	2	100	2	16325480
Pubmed	Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent.	TLR4 IL4R	8.18e-06	2	100	2	20404812
Pubmed	The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.	CENPT CENPN KNL1	1.02e-05	15	100	3	16622420
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	OBSCN SMURF1 LRRC4C NCOA5 KNL1	1.13e-05	101	100	5	10997877
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	EP400 TTC28 NOL6 LGR4 TNRC6B LRIG2 UBR5 EIF2S3 SEC24B CUX1 EPB41L2	1.50e-05	777	100	11	35844135
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	EP400 CUL7 TEX10 CLOCK UBR5 CUX1 KNL1	1.80e-05	282	100	7	23667531
Pubmed	A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis.	PCNX3 NOL6 UBR5 CUX1	1.96e-05	55	100	4	34237211
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	EP400 ARHGAP11A UBR5 CUX1 KNL1	2.21e-05	116	100	5	30804394
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SEMA6C EP400 TOPBP1 E2F3 ARHGAP11A CLOCK NAV2 SENP6 ESPL1	2.27e-05	529	100	9	14621295
Pubmed	Different expression of CD180, CD284 and CD14 receptors on the CD19+ subpopulation of normal and B-CLL lymphocytes.	TLR4 CD180	2.45e-05	3	100	2	20430725
Pubmed	Human endogenous retrovirus W family envelope gene activates the small conductance Ca2+-activated K+ channel in human neuroblastoma cells through CREB.	ERVW-1 KCNN3	2.45e-05	3	100	2	23727510
Pubmed	A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15.	KMT2A KNL1	2.45e-05	3	100	2	12618766
Pubmed	Synergistic effects of NOD1 or NOD2 and TLR4 activation on mouse sickness behavior in relation to immune and brain activity markers.	NOD1 TLR4	2.45e-05	3	100	2	25218901
Pubmed	Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritis.	NOD1 TLR4	2.45e-05	3	100	2	17309748
Pubmed	RP105 involved in activation of mouse macrophages via TLR2 and TLR4 signaling.	TLR4 CD180	2.45e-05	3	100	2	23483427
Pubmed	TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.	TLR4 CD180	2.45e-05	3	100	2	32521253
Pubmed	Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages.	NOD1 TLR4	2.45e-05	3	100	2	20649597
Pubmed	Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis.	NOD1 TLR4	2.45e-05	3	100	2	26989200
Pubmed	NOD1 downregulates intestinal serotonin transporter and interacts with other pattern recognition receptors.	NOD1 TLR4	2.45e-05	3	100	2	29030987
Pubmed	LncRNA HOTTIP regulates TLR4 promoter methylation by recruiting H3K4 methyltransferase MLL1 to affect apoptosis and inflammatory response of fibroblast-like synoviocyte in rheumatoid arthritis.	TLR4 KMT2A	2.45e-05	3	100	2	38363110
Pubmed	Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.	CHD1 KMT2A	2.45e-05	3	100	2	22046413
Pubmed	Reduced surface expression of TLR4 by a V254I point mutation accounts for the low lipopolysaccharide responder phenotype of BALB/c B cells.	TLR4 CD180	2.45e-05	3	100	2	23203928
Pubmed	Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome.	IL4R GP1BA	2.45e-05	3	100	2	12200373
Pubmed	A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.	TOPBP1 TP53BP1	2.45e-05	3	100	2	11756551
Pubmed	Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity.	NOD1 TLR4	2.45e-05	3	100	2	20081863
Pubmed	Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair.	TLR4 KMT2A	2.45e-05	3	100	2	32205424
Pubmed	Mus spretus SEG/Pas mice resist virulent Yersinia pestis, under multigenic control.	NOD1 TLR4	2.45e-05	3	100	2	20861861
Pubmed	NOD1 gene E266K polymorphism is associated with disease susceptibility but not with disease phenotype or NOD2/CARD15 in Hungarian patients with Crohn's disease.	NOD1 TLR4	2.45e-05	3	100	2	17964870
Pubmed	Variation in Cilia Protein Genes and Progression of Lung Disease in Cystic Fibrosis.	DNAH14 DNAH6	2.45e-05	3	100	2	29323929
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	EP400 TTC28 RBBP6 TNRC6B SEC24B KMT2A PCBP2 CUX1 TP53BP1	3.04e-05	549	100	9	38280479
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	CENPT NOL6 ARHGAP11A UBR5 KMT2A KNL1	3.35e-05	210	100	6	16565220
Pubmed	A new mechanism for inhalational priming: IL-4 bypasses innate immune signals.	TLR4 IL4R	4.89e-05	4	100	2	18981153
Pubmed	The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells.	TLR4 CD180	4.89e-05	4	100	2	22354914
Pubmed	A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4Rα) & Toll-like receptor 4 (TLR4) genes with asthma in Indian adults.	TLR4 IL4R	4.89e-05	4	100	2	26831416
Pubmed	Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression.	LGR4 TLR4	4.89e-05	4	100	2	23589304
Pubmed	Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.	EIF2S3B EIF2S3	4.89e-05	4	100	2	31836389
Pubmed	An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.	CLOCK KMT2A	4.89e-05	4	100	2	23399917
Pubmed	PIWIL1 suppresses circadian rhythms through GSK3β-induced phosphorylation and degradation of CLOCK and BMAL1 in cancer cells.	PIWIL1 CLOCK	4.89e-05	4	100	2	31099187
Pubmed	An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1.	TLR4 CD180	4.89e-05	4	100	2	21857663
Pubmed	The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells.	TLR4 CD180	4.89e-05	4	100	2	10880523
Pubmed	In vivo expression of Toll-like receptor 2, Toll-like receptor 4, CSF2 and LY64 in Chinese chronic periodontitis patients.	TLR4 CD180	4.89e-05	4	100	2	20233331
Pubmed	Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages.	TLR4 IL4R	4.89e-05	4	100	2	25611587
Pubmed	Functional proteomics mapping of a human signaling pathway.	RBBP6 SMURF1 LMO4 TEX10 DHX30 UBR5 PDE4DIP PCBP2 KNL1	5.36e-05	591	100	9	15231748
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	EP400 TTC28 RBBP6 NOL6 CHD1 ANGEL2 KMT2A TP53BP1	6.49e-05	469	100	8	27634302
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	CENPT TOPBP1 E2F3 CHD1 ARHGAP11A SENP6 KMT2A PRDM15 CUX1	6.66e-05	608	100	9	36089195
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CENPN OBSCN SMURF1 LGR4 MAP3K3 INF2 TLR4 SERINC3 ESPL1 CNOT2 LRRC18 TP53BP1	6.68e-05	1084	100	12	11544199
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	EP400 NOL6 TNRC6B CHD1 DNAAF2 CUX1 TP53BP1 KNL1	6.78e-05	472	100	8	38943005
Pubmed	The histone methyltransferase MLL1 permits the oscillation of circadian gene expression.	CLOCK KMT2A	8.14e-05	5	100	2	21113167
Pubmed	Toll-like receptor (TLR) and nucleosome-binding oligomerization domain (NOD) gene polymorphisms and endometrial cancer risk.	NOD1 TLR4	8.14e-05	5	100	2	20646321
Pubmed	Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages.	NOD1 TLR4	8.14e-05	5	100	2	17118979
Pubmed	Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells.	PIWIL1 CLOCK	8.14e-05	5	100	2	22900038
Pubmed	Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians.	NOD1 TLR4	8.14e-05	5	100	2	21864388
Pubmed	HIV Tat acts on endogenous retroviruses of the W family and this occurs via Toll-like receptor 4: inference for neuroAIDS.	ERVW-1 TLR4	8.14e-05	5	100	2	25250834
Pubmed	The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.	TLR4 CD180	8.14e-05	5	100	2	15905547
Pubmed	TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.	UBR5 TP53BP1	8.14e-05	5	100	2	22884692
Pubmed	Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.	NCOA5 SEC24B PCBP2 TP53BP1	8.60e-05	80	100	4	16094384
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CENPT EP400 TTC28 TOPBP1 TNRC6B ARHGAP11A MED19 KMT2A PRDM15	1.04e-04	645	100	9	25281560
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NOL6 CHD1 CUL7 TEX10 DHX30 UBR5 KMT2A EPB41L2 TP53BP1	1.14e-04	653	100	9	22586326
Pubmed	Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells.	SMURF1 MAP3K3	1.22e-04	6	100	2	19318350
Pubmed	BRCT repeats as phosphopeptide-binding modules involved in protein targeting.	TOPBP1 TP53BP1	1.22e-04	6	100	2	14576432
Pubmed	Mucosal clearance of capsule-expressing bacteria requires both TLR and nucleotide-binding oligomerization domain 1 signaling.	NOD1 TLR4	1.22e-04	6	100	2	19017981
Pubmed	Mast cell-mediated immune responses through IgE antibody and Toll-like receptor 4 by malarial peroxiredoxin.	TLR4 CD180	1.22e-04	6	100	2	18398934
Pubmed	Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.	NOD1 TLR4	1.22e-04	6	100	2	16984919
Pubmed	Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.	NOD1 TLR4	1.22e-04	6	100	2	22902233
Pubmed	Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.	SMURF1 TLR4	1.22e-04	6	100	2	21897371
Pubmed	TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation.	NOD1 TLR4	1.22e-04	6	100	2	22033934
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	EP400 GNE UBE4B NOL6 CHD1 TEX10 DHX30 UBR5 INF2 SEC24B EXOC2 EPB41L2 TP53BP1	1.35e-04	1353	100	13	29467282
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	CENPT NOL6 CHD1 TEX10 NAA25 MED19 KMT2A EPB41L2	1.56e-04	533	100	8	30554943
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	LGR4 TNRC6B ZNHIT3 NAA25 PCBP2 CNOT2 CUX1 EPB41L2	1.63e-04	536	100	8	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	LGR4 TNRC6B ZNHIT3 NAA25 PCBP2 CNOT2 CUX1 EPB41L2	1.67e-04	538	100	8	10512203
Pubmed	Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development.	NOD1 TLR4	1.70e-04	7	100	2	19933833
Pubmed	Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.	TOPBP1 UBR5	1.70e-04	7	100	2	11714696
Pubmed	Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.	EIF2S3B EIF2S3	1.70e-04	7	100	2	15669143
Pubmed	E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.	E2F3 KMT2A	1.70e-04	7	100	2	17612494
Pubmed	Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.	NOD1 TLR4	1.70e-04	7	100	2	18987631
Interaction	NUP43 interactions	CENPT EP400 RBBP6 NOL6 TOPBP1 TNRC6B CHD1 CCDC168 CUL7 TEX10 UBR5 SENP6 KMT2A KNL1	2.21e-06	625	99	14	int:NUP43
Interaction	SNRNP40 interactions	CENPT EP400 RBBP6 NOL6 CHD1 CUL7 TEX10 NCOA5 UBR5 SENP6 KMT2A EPB41L2 KNL1	1.42e-05	637	99	13	int:SNRNP40
Interaction	SLX4 interactions	EP400 TOPBP1 CHD1 ARHGAP11A TEX10 DHX30 UBR5 EIF2S3 SENP6 ZNF518B PCBP2 TP53BP1	2.38e-05	572	99	12	int:SLX4
Coexpression	FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP	EP400 CHD1 ARHGAP11A UBR5 INF2 ESPL1 KNL1	3.24e-06	164	100	7	M19957
Coexpression	GSE8835_CD4_VS_CD8_TCELL_UP	CENPN UBE4B NOL6 CUL7 NAV2 KCNN3 CUX1	1.19e-05	200	100	7	M6254
Coexpression	GSE21063_WT_VS_NFATC1_KO_BCELL_DN	UBE4B TOPBP1 ARHGAP11A TEX10 SENP6 PCBP2 GPANK1	1.19e-05	200	100	7	M8261
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	E2F3 EIF2S3B CCDC168 CUL7 USF3 LRRIQ1	3.62e-06	183	100	6	3cbe0175d05fd39bc430de1ef471ff2c5b56460e
ToppCell	Dividing_Macrophages-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CENPN ARHGAP11A CCDC34 CD180 ESPL1 KNL1	3.98e-06	186	100	6	0067eb78d4c7e32b9563550d9fcaf13445ee6a48
ToppCell	Control-Lymphoid-Proliferating_CD4_T_cells\|Lymphoid / Condition, Lineage and Cell class	CENPN ARHGAP11A CCDC34 TLR4 TREM2 KNL1	5.22e-06	195	100	6	578bbb06a5476c08fc3b351cc580c551dfe53ae4
ToppCell	BAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CENPN ARHGAP11A CCDC34 NAV2 ESPL1 KNL1	5.37e-06	196	100	6	6d80e23f6a1725a3f5ea7263233c55c2ea56f977
ToppCell	BAL-Control-Myeloid-Myeloid\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPN ARHGAP11A CCDC34 NAV2 ESPL1 KNL1	5.37e-06	196	100	6	bf1d3fae8c01bb3d17c2dafad92b94937c663acd
ToppCell	BAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CENPN ARHGAP11A CCDC34 NAV2 ESPL1 KNL1	5.37e-06	196	100	6	3dd7ed1dfac8d90c8a44f0ae00128bb46d9ef496
ToppCell	BAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPN ARHGAP11A CCDC34 NAV2 ESPL1 KNL1	5.37e-06	196	100	6	4f649e3bfd21f21682678828673843a7d51c4ff2
ToppCell	BAL-Control-Myeloid-Myeloid\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CENPN ARHGAP11A CCDC34 NAV2 ESPL1 KNL1	5.37e-06	196	100	6	799c290fb3dfacb666dd0dc3c43ec8a86b697ec7
ToppCell	BAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPN ARHGAP11A CCDC34 NAV2 ESPL1 KNL1	5.37e-06	196	100	6	0c003a767c3b58605099dab64b9df0d8e5d8bc4b
ToppCell	Control-Myeloid-proliferating_Myeloid_cells\|Control / Disease group,lineage and cell class （2021.01.30）	CENPN ARHGAP11A CCDC34 NAV2 ESPL1 KNL1	5.53e-06	197	100	6	ddbe3fe078766bb55f0d7ca1aeb8f9e4aa696d8e
ToppCell	Healthy_Control-Lymphoid-T-Proliferating_T\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CENPN ARHGAP11A CCDC34 NAV2 ESPL1 KNL1	5.53e-06	197	100	6	3ce3dcbbe0edeb5a6fb5596dd6c2b4d6c1d5159d
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARMC2 PLEKHG4B LRRIQ1 KCNN3 ULK4 DNAH6	5.53e-06	197	100	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast-MyoFB-1\|E18.5-samps / Age Group, Lineage, Cell class and subclass	SEMA6C RGR CILP2 LRRIQ1 ULK4	1.91e-05	145	100	5	ac41c6c02b7d78162b86222983688f54d04ac47d
ToppCell	PND07-28-samps-Mesenchymal-Pericyte-pericyte_F\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	NMUR1 LRRC4C KANK4 ZNF518B LRRC18	2.25e-05	150	100	5	2d0d6dc07dcfe28e3d7694c52d15d17dae2fd47b
ToppCell	PND07-28-samps-Mesenchymal-Pericyte\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	NMUR1 LRRC4C KANK4 ZNF518B LRRC18	2.25e-05	150	100	5	5b111ec11a642d63fafa7e1422e36f81a2776531
ToppCell	severe_influenza-NK_CD56bright\|World / disease group, cell group and cell class (v2)	PIWIL1 CCDC168 ERVW-1 CLOCK UTS2	2.55e-05	154	100	5	187b9d4eb0e98c506034735601ead480ff00bd57
ToppCell	severe_influenza-NK_CD56bright\|severe_influenza / disease group, cell group and cell class (v2)	PIWIL1 CCDC168 ERVW-1 CLOCK UTS2	2.80e-05	157	100	5	fabaf54429dd5a899f9192f0d42522109ca36b9b
ToppCell	PND01-03-samps-Myeloid-Macrophage-CD163+_Macrophage\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CENPN LRRC25 TREM2 ADGRE4P KNL1	3.06e-05	160	100	5	4480a7d6bd48d06b4e5196faac868f31ab7ed3ad
ToppCell	LPS-antiTNF-Endothelial-Endothelial-FOXM1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CENPN PIWIL1 SLCO1B3 ARHGAP11A KNL1	3.35e-05	163	100	5	5285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell	E15.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LRRC25 TLR4 TREM2 CD180 IL4R	3.55e-05	165	100	5	8d3d5860a4785c4908160ae5fcb421ee80bd78ce
ToppCell	E15.5-Endothelial-lymphatic_endothelial_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LRRC25 TLR4 TREM2 CD180 IL4R	3.55e-05	165	100	5	17ee6f269ed8d378465cf00ca59d48d8b106808e
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USF3 IGHD CD180 IL4R EPB41L2	3.55e-05	165	100	5	fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC25 TLR4 TREM2 ADGRE4P CD180	3.65e-05	166	100	5	03a47b8687f54955e84df1edcb230db332c4ca8f
ToppCell	Thalamus-Hematopoietic\|Thalamus / BrainAtlas - Mouse McCarroll V32	LRRC25 IGHD TREM2 CD180 ESPL1	3.65e-05	166	100	5	76d60ac7ac5d1eaf530f0c741d9c48e0bd58396b
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CENPN PIWIL1 ARHGAP11A ESPL1 KNL1	3.98e-05	169	100	5	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CENPN ARHGAP11A CCDC34 PRDM15 KNL1	4.32e-05	172	100	5	7f3d0ef18f5df1ed80498d435b0378ca398c0b88
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SEMA6C CENPN CCDC34 ESPL1 KNL1	4.32e-05	172	100	5	6fcc16f1067672967ecbcdfdc727649ae9891dd9
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	4.70e-05	175	100	5	a154b28b0b2180652d51d4c7d804b3b81b35899e
ToppCell	(01)_Cycling_Basal_(homeostasis)\|World / shred by cell type and Timepoint	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	4.96e-05	177	100	5	05c57578142a6662f18b294d5cc11e6efd6b0f8e
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-8\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HEXD DNAH14 IGHD CD180 EPB41L2	4.96e-05	177	100	5	066e7500e7bdde88a7914f50a4661d8adf6db925
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP11A TEX10 LRRC25 TLR4 ZNF518B	4.96e-05	177	100	5	68f1139fc378f351e3b9e9f392aacb150025bf03
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	CENPN CUL7 ANGEL2 TREM2 PRDM15	5.09e-05	178	100	5	536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CENPN ARHGAP11A CCDC34 TTC38 KNL1	5.09e-05	178	100	5	dbde3305e0c6a81593fe614e3f2e746b32cc16a7
ToppCell	Dividing_Macrophages-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	5.09e-05	178	100	5	1893fadac2ec3d5de0a641e57b7b2f962012a9ba
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	5.37e-05	180	100	5	5e1680088065be14447d5d5465f91f7edd071a1e
ToppCell	LPS-IL1RA-Endothelial-Endothelial-FOXM1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CENPN PIWIL1 ARHGAP11A ESPL1 KNL1	5.37e-05	180	100	5	334e2b1f6eb7d4ece20b1c7b02107863f913237f
ToppCell	IIH-cycling-\|IIH / Condition, Cell_class and T cell subcluster	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	5.51e-05	181	100	5	7f4fed9e296bc22cb5a1e6c8e3c4b641e97c3078
ToppCell	IIH-cycling\|IIH / Condition, Cell_class and T cell subcluster	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	5.51e-05	181	100	5	ec3e782ce93dcfe1a54fb7284e4e39063614b0e2
ToppCell	390C-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	OMG LRRIQ1 KCNN3 DNAH6 LRRC18	6.43e-05	187	100	5	88f785932e67c613db0dda84496de351359ed962
ToppCell	390C-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	OMG LRRIQ1 KCNN3 DNAH6 LRRC18	6.43e-05	187	100	5	8896a00b30d11b90ca42726d4e122174a30b161b
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TEX10 CLOCK UBR5 KMT2A CNOT2	6.59e-05	188	100	5	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TEX10 CLOCK UBR5 KMT2A CNOT2	6.59e-05	188	100	5	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TEX10 CLOCK UBR5 KMT2A CNOT2	6.59e-05	188	100	5	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GNE LRRC4C DNAH14 ADAMTS15 DNAH6	6.76e-05	189	100	5	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	Dividing_Macrophages-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	6.76e-05	189	100	5	d4e88a3e50499d683e3db38aee04490146fe30bb
ToppCell	Control-Endothelial-Endothelial-FOXM1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CENPN ARHGAP11A NAV2 ESPL1 KNL1	6.76e-05	189	100	5	1e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell	Dividing_Macrophages-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.11e-05	191	100	5	3e567ed6b5fefafa7f460e49d25d60bb52a0a6c8
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-Cycling_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	CENPN ARHGAP11A CD180 EPB41L2 KNL1	7.11e-05	191	100	5	aa9c0b1b90cdb7a95d4e6332819f82cae0a79ff9
ToppCell	droplet-Spleen-SPLEEN-30m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPN E2F3 CCDC34 ESPL1 KNL1	7.11e-05	191	100	5	c8b99bd3a30c81ee4deba9cbf0196920ab3ab550
ToppCell	(3)_Macrophage_Dividing\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	CENPN ARHGAP11A CCDC34 TREM2 KNL1	7.11e-05	191	100	5	b42f0b89bb94fd43786ff50f1caeb3ebfbbb43fd
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CENPN ARHGAP11A NAV2 ESPL1 KNL1	7.28e-05	192	100	5	27723f4e320e49d4a3daafa2d8d3946ff79fab64
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CENPN ARHGAP11A NAV2 ESPL1 KNL1	7.28e-05	192	100	5	0a54c79dcfdeb99e3b512d42b22359618cfd17e9
ToppCell	Dividing_Macrophages-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.28e-05	192	100	5	741bd0c2b0a7ce3fcb1610ce8bdacaf9a803c212
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	ARMC2 OMG LRRIQ1 ULK4 DNAH6	7.46e-05	193	100	5	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	Control-Lymphoid-Proliferating_CD4_T_cells\|Control / Condition, Lineage and Cell class	ARHGAP11A CCDC34 NAV2 ESPL1 KNL1	7.46e-05	193	100	5	33d409d6ed1c606337248587ad997ac5f67f081d
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.65e-05	194	100	5	f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCell	3'_v3-Lung-Myeloid_Mac-Cycling_Myeloid-Mac\|Lung / Manually curated celltypes from each tissue	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.65e-05	194	100	5	a8ae49157ca3f9e8b3f1750a995aee012dc859b6
ToppCell	(1)_T_cells_Dividing\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.65e-05	194	100	5	8f313071933451780309d2174ed27d8cdc734343
ToppCell	Control-Lymphoid_T/NK-T/NK_proliferative\|Control / Disease group, lineage and cell class	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.65e-05	194	100	5	9bbb124001fba7450f4639f47f9b720a483e7242
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.65e-05	194	100	5	a75ecd0b0a928d4646602f7d16a645f6b3df3af5
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.65e-05	194	100	5	17744fd6645cf5a447a01a83f07e8d305c2bcd9c
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.65e-05	194	100	5	e14f66f7584909621b776292fbd52808273fd2ee
ToppCell	Dividing_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.83e-05	195	100	5	79ee423df85aa1631b7bdea74eacaf826dfc4a2c
ToppCell	Dividing_cells-Dividing_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.83e-05	195	100	5	19829760dfcc0edafd2a2bd80f424a45d039af1f
ToppCell	tumor_Lung-B_lymphocytes-GC_B_cells_in_the_DZ\|B_lymphocytes / Location, Cell class and cell subclass	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.83e-05	195	100	5	339e81a3a5b1f71c0d15ef1ef0f6999378704923
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.83e-05	195	100	5	926eb3fc5d028be936885bea0654a77db3107234
ToppCell	(1)_T_cells-(1)_T_cells_Dividing\|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.83e-05	195	100	5	cf00a0b4f341f0487d5b37810abe2952fdd3f6f2
ToppCell	Healthy/Control-T/NK_proliferative\|Healthy/Control / Disease group and Cell class	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.83e-05	195	100	5	957458fdc39723f4a31bd7fd3ce32891aa3fd462
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CENPN ARHGAP11A NAV2 ESPL1 KNL1	7.83e-05	195	100	5	742c82c86487314cdb3178012004adb1164bcbdb
ToppCell	mild-Lymphocytic-Prol._cells\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	7.83e-05	195	100	5	9a8cc9097a349fd0a53ccf2723ee8bb1418d6aca
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGAP11A CCDC34 SERINC3 ESPL1 KNL1	7.83e-05	195	100	5	a838bddeed487154791b69d27a68673783ff63c0
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.03e-05	196	100	5	73f951f7712e0aa3323676b9a4b7944d21d347c4
ToppCell	Healthy-T/NK_proliferative\|Healthy / disease group, cell group and cell class	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.03e-05	196	100	5	91e44aabb2e85dcc77ddae6f7e000118d45d1de6
ToppCell	Control-T/NK_proliferative\|Control / Disease condition and Cell class	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.03e-05	196	100	5	7b7bc25aef49bfd64f79303a92d527bf8188f7a6
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.22e-05	197	100	5	4b13335a43b9d6abc8e542e72440da7feb82fbe6
ToppCell	Healthy/Control-T/NK_proliferative\|World / Disease group and Cell class	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.22e-05	197	100	5	4a4d3083938783d6f5b87da02f10e501917da0b4
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic-lymphocyte-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.22e-05	197	100	5	21861d8b389fafbdb7c3499684c9b6deee3dbd5e
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPN ARHGAP11A CCDC34 CUX1 KNL1	8.22e-05	197	100	5	9b2c67de46bd59bf56c81a0d10b84cf4a041c120
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.22e-05	197	100	5	47be19f595135da248469b2e21b8d88f561827b2
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic-lymphocyte\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.22e-05	197	100	5	ffb004c37cdd26cb7cdcd80f769a2eded65416dc
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CENPN LGR4 ARHGAP11A CCDC34 KNL1	8.42e-05	198	100	5	1fa213e79d828bff6465bde116536dd1b80d94e0
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_NK-Cycling_NK\|lymph-node_spleen / Manually curated celltypes from each tissue	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	b2868a897dd96494cf1829c30e0ce508f52efdf3
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_dorsal_progenitors\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	5f0964c3aa7e1dc52cbb46e754078920b65bcb88
ToppCell	(3)_DC_Monocyte_Dividing\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	e2b89f6d7c0007ccab62495cd543fe0e5513a9a4
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	629d674a9c9108c1acb3f7af57bbdbf34bb0528e
ToppCell	metastatic_Lymph_Node-T/NK_cells-Undetermined\|metastatic_Lymph_Node / Location, Cell class and cell subclass	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	f9f083c76c51b6f014ecf80eaec957eff8d1ab75
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CENPN ARHGAP11A NAV2 ESPL1 KNL1	8.42e-05	198	100	5	c3dd887c95587f930b7afd32385627a9fa029ca4
ToppCell	medial-2-Hematologic-Proliferating_Macrophage\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	64a2bcf5a9ba66a4fe08fbde33f1886c136cde8f
ToppCell	medial-Hematologic-Proliferating_Macrophage-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	fcc14ac3eb5088b9d6cd6af5a34dee5b81c0ece8
ToppCell	distal-1-Hematologic-Proliferating_Macrophage\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	df3f5559ecd1f3cd1fd60e39dbad8741309e83a3
ToppCell	normal_Lymph_Node-T/NK_cells-Undetermined\|T/NK_cells / Location, Cell class and cell subclass	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	47d572b9db2843aeb2079f33a852babf67270be4
ToppCell	distal-Hematologic-Proliferating_Macrophage-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	8afeb1f9bc9d8551482c8fefe4c5f88d9cd13ee2
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	48d39018c56ea8ba972c72af8ece10cbeb48fbc8
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	281fc2536cdc4c717b30de156e563c0e4baba99d
ToppCell	356C-Myeloid-Dendritic-cDC_proliferating_1\|356C / Donor, Lineage, Cell class and subclass (all cells)	CENPN ARHGAP11A CCDC34 TREM2 KNL1	8.42e-05	198	100	5	f801157468e59b5d049f703feadc9bb0f11e85cc
ToppCell	(1)_T_cell_dividing\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	dac3a16e3a070a37f4d0ea37633c23fdc8a9c70a
ToppCell	medial-Hematologic-Proliferating_Macrophage\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.42e-05	198	100	5	da6963184c32761c896a9b91a5321ad84b583736
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.62e-05	199	100	5	11c3d9fe811a4619347f47d2b0e94066e3085625
ToppCell	15-Airway-Mesenchymal-Mesenchyme_RSPO2+\|Airway / Age, Tissue, Lineage and Cell class	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.62e-05	199	100	5	5c8b847b794b3e88722f5b841f2539a27251106c
ToppCell	Non-neuronal-Dividing-IPC-IPC-div1-28\|World / Primary Cells by Cluster	CENPN ARHGAP11A CCDC34 ESPL1 KNL1	8.62e-05	199	100	5	787688b68ae5d8768c0a24673ae07ab07616764a
Drug	Prednicarbate [73771-04-7]; Down 200; 8.2uM; PC3; HT_HG-U133A	TTC28 BBS1 CUL7 NOD1 PDE4DIP SENP6 KMT2A TTC38	2.04e-06	193	99	8	5119_DN
Disease	MEHMO syndrome (implicated_via_orthology)	EIF2S3B EIF2S3	1.14e-05	2	100	2	DOID:0060801 (implicated_via_orthology)
Disease	glucose metabolism disease (implicated_via_orthology)	EIF2S3B EIF2S3 TLR4	1.16e-04	28	100	3	DOID:4194 (implicated_via_orthology)
Disease	hypopituitarism (implicated_via_orthology)	EIF2S3B EIF2S3	1.69e-04	6	100	2	DOID:9406 (implicated_via_orthology)
Disease	Focal Segmental Glomerulosclerosis, Not Otherwise Specified	E2F3 INF2	4.03e-04	9	100	2	C4049702
Disease	leukodystrophy (implicated_via_orthology)	EIF2S3B EIF2S3	4.03e-04	9	100	2	DOID:10579 (implicated_via_orthology)
Disease	C-reactive protein measurement	SEMA6C UBE4B CCDC168 BCL3 CILP2 LRRC25 CCDC34 TREM2 KCNN3 IL4R CUX1 TP53BP1	7.86e-04	1206	100	12	EFO_0004458
Disease	serum albumin measurement	E2F3 ARMC2 CLOCK CILP2 LRRC25 KCNN3 EXOC2 TP53BP1	9.25e-04	592	100	8	EFO_0004535
Disease	phospholipids in VLDL measurement	MPP3 BCL3 TP53BP1	1.07e-03	59	100	3	EFO_0022301
Disease	total lipids in small VLDL	MPP3 BCL3 TP53BP1	1.55e-03	67	100	3	EFO_0022148
Disease	skin hydration measurement	PIWIL1 LRRC4C	2.29e-03	21	100	2	EFO_0009586
Disease	cerebellar cortex volume measurement	LRRC4C CUX1	2.29e-03	21	100	2	EFO_0010291
Disease	Kidney Failure	INF2 TLR4	2.51e-03	22	100	2	C0035078
Disease	Colorectal Carcinoma	OBSCN SLCO1B3 CHD1 GDAP1L1 TLR4 TENM1 ADAMTS15 CUX1	2.69e-03	702	100	8	C0009402
Disease	late-onset Alzheimers disease	IRAK1BP1 GDAP1L1 SEC24B TREM2 DNAH6	3.21e-03	292	100	5	EFO_1001870
Disease	physical activity	RBBP6 E2F3 TLR4	3.36e-03	88	100	3	EFO_0003940

Protein segments in the cluster

Peptide	Gene	Start	Entry
TLSHSQLRQLTAGQP	EP400	1636	Q96L91
LPLSGHSALSIQELV	CUX1	1106	P39880
LPNSGHLLVQVTATL	ARMC2	441	Q8NEN0
RPIQNTSTSLHLELS	ADGRE4P	216	Q86SQ3
QQLSEDTLTIHGLPT	C22orf31	196	O95567
HRGNEVSTTPLLANS	ANKRA2	136	Q9H9E1
HLLSSLQLLPNRTGS	DNHD1	2596	Q96M86
RPDNLSQTSLIHLSS	ANGEL2	96	Q5VTE6
SSQVHPLAVLLLTDG	DHX30	1091	Q7L2E3
HQLSTLVLTGNPLIF	CD180	101	Q99467
NHRLLITGTPLQNSL	CHD1	636	O14646
LELNSSSSHNTLRPA	DISP2	236	A7MBM2
LQHSLSTEPAVVLGL	DISP2	956	A7MBM2
RGPSVLHNSVLSLSN	ADAMTS15	816	Q8TE58
GDIHTTLLSAVIPNA	GDAP1L1	316	Q96MZ0
GLRHPLSSTQAQTAT	IRAK1BP1	36	Q5VVH5
LCSLPNTSLHGIRQL	NMUR1	191	Q9HB89
RTSTAHLLSLSQGPQ	GPANK1	231	O95872
LSSLLNKTTVHNIPG	DNAAF2	786	Q9NVR5
RPTALINGHLNSLQS	LMO4	141	P61968
SGLSLSLPHNQSLRA	LRRC25	46	Q8N386
RITPLSLQTQGSSHE	EPB41L2	671	O43491
LTTSLAGSHPQLRAL	PCNX3	1786	Q9H6A9
NDTRPSVLGHLSQTA	EXOC2	411	Q96KP1
STAILHPSSRQGSQL	KCNN3	116	Q9UGI6
QIQSGILRLFSLPHS	OR51B6	296	Q9H340
TLIQSGPALSHLVSQ	NCOA5	546	Q9HCD5
QSLDTPETNRTLHLT	CUL7	671	Q14999
TRQLPLLTSALHGLQ	NOL6	831	Q9H6R4
PGSNILALVTQVSLH	HEXD	361	Q8WVB3
LRNHPSLTTLSLASN	NOD1	836	Q9Y239
VNLGLNHLDSVPTTL	LRRC18	126	Q8N456
HTLQILPATGNFSEI	KNL1	351	Q8NG31
QFPNLTGTVHLESLT	LGR4	311	Q9BXB1
PDGISTNTRLLNLHE	LRRC4C	71	Q9HCJ2
QGLLHLEPTLRSSQL	INF2	296	Q27J81
TRFPSQTLLLSNQLH	LRRIQ1	1456	Q96JM4
TPSLLGQSLLHGQLI	RBBP6	471	Q7Z6E9
SELLQHGLPQISSRS	MEI1	656	Q5TIA1
QTTSHELTIPNDLIG	PCBP2	286	Q15366
HQPSQEGLTLRLTIS	OBSCN	2961	Q5VST9
SGHLQVNTTLPARTL	RGR	206	P47804
QNILSHPISIRLGSF	DNAH6	3436	Q9C0G6
QGLTVPSNSHLVLVL	ESPL1	1881	Q14674
PGNLTVHTNVSDTLL	IL4R	126	P24394
SIESLQIHLASTQGP	E2F3	331	O00716
NSVDLRTPLSDTLHL	GNE	496	Q9Y223
NSTRSLLSPLGHQSF	CCDC34	61	Q96HJ3
QASGHLEEQTPRTLL	CENPT	76	Q96BT3
GSQSQHSRLTLPRSL	IGHD	226	P01880
HNSTTPLQERSLGLD	CENPN	216	Q96H22
SNARTPLILIQTHGS	DNAH14	3056	Q0VDD8
TLPVLGTLDLSHNQL	GP1BA	91	P07359
HLPETGTTTDQLLRQ	KANK4	761	Q5T7N3
PSLLDLGSLNTSSHR	KMT2A	3266	Q03164
LGSLNTSSHRTVPNI	KMT2A	3271	Q03164
GQPHLSRQDLTTLDV	EIF2S3B	11	Q2VIR3
LSHTQPTQIESLAEG	CCDC168	2471	Q8NDH2
GRSPLIHAVENNSLS	BCL3	276	P20749
LTLHLQNTSTTRPVL	BBS1	501	Q8NFJ9
TNTRETHSALGPALQ	SEC24B	781	O95487
HQGNLFTLVPSSRSL	MAP3K3	301	Q99759
IDLPGSHDNSSLRSL	MED19	116	A0JLT2
HETLALLTSQLRPDS	MPP3	11	Q13368
GAGQPTSHLVLTTLL	MROH5	836	Q6ZUA9
LVGQSIHREPNLSLS	PIWIL1	841	Q96J94
SGQDPNILLSHLLAR	UTS2	91	O95399
SSLSPVLIGGNHLIT	ARHGAP11A	381	Q6P4F7
GPLVSNLEITHTSNL	ERVW-1	221	Q9UQF0
LGSPIQDVAITLHSL	GFM2	641	Q969S9
GLLLIITPDSSHQNR	BMT2	271	Q1RMZ1
LALQGLNPSRHTSAV	RNF165	221	Q6ZSG1
GHLTTPERQLQLDNS	PRDM15	1391	P57071
TPLLRNSHSNSLISE	NAV2	1881	Q8IVL1
HSPRNLILTSLQETG	TENM1	481	Q9UKZ4
LSTLPSGLQENIIHL	OMG	46	P23515
LLQGHTSEPRDLNSV	SMURF1	286	Q9HCE7
LQTSRLLHGNPSTQL	CLOCK	786	O15516
ILHTSQSNTIPLGEL	CILP2	561	Q8IUL8
LNRSLSQGTQLPSHV	CNOT2	96	Q9NZN8
SSPVILQFGHAETLL	MINPP1	361	Q9UNW1
SGLQNNTSPIIHSIL	PLEKHG4B	276	Q96PX9
SHTALVLQGSLTQPR	UBE4B	466	O95155
ASHANFLLGIITIPT	SLCO1B3	371	Q9NPD5
HLGSRNPELSTQLID	TEX10	561	Q9NXF1
HQPLLTLTSRALLTQ	SEMA6C	411	Q9H3T2
ESTGPLLRTSIHQNS	SENP6	246	Q9GZR1
PHLSDQVIGSQRSLS	USF3	1826	Q68DE3
SVPLHLSLTETQSQG	TP53BP1	686	Q12888
QEHQPRSGLLQSSLI	SERINC3	261	Q13530
GTLTITLRNLQPHDA	TREM2	91	Q9NZC2
LGAHDPQTTQELLTT	TTC38	341	Q5R3I4
SSLIGQALTEILQHP	TTC28	1721	Q96AY4
LSHLSTLILTGNPIQ	TLR4	101	O00206
INLNSDTAEHPGTRL	TOPBP1	756	Q92547
GESATLRSLLLNPHL	ZNHIT3	96	Q15649
VLHNLTPQIDGSTLR	TNRC6B	1651	Q9UPQ9
ATNLVTLPNSRGEHL	UBR5	1261	O95071
PLTKITSGHLSQQDL	ULK4	391	Q96C45
SGRNLHSSSQQLLPF	ZNF518B	516	Q9C0D4
GQPHLSRQDLTTLDV	EIF2S3	11	P41091
GEPTSNITLLSLVHN	LRIG2	116	O94898
SLTLRLISGLPSLNH	NAA25	691	Q14CX7
AFSLPGSTQHLRSQL	PDE4DIP	1206	Q5VU43