Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	ARID1B CHD5 GON4L YY1AP1 CHD3	4.87e-06	96	54	5	GO:0070603
GeneOntologyCellularComponent	ATPase complex	ARID1B CHD5 GON4L YY1AP1 CHD3	2.05e-05	129	54	5	GO:1904949
GeneOntologyCellularComponent	nuclear body	EIF4ENIF1 CHD5 SETBP1 ZNF638 BARD1 GON4L YY1AP1 CHD3 YME1L1 NCBP3	9.14e-05	903	54	10	GO:0016604
GeneOntologyCellularComponent	parallel fiber to Purkinje cell synapse	STXBP1 SNAP91 PCLO	1.87e-04	43	54	3	GO:0098688
GeneOntologyCellularComponent	presynaptic active zone	STXBP1 SNAP91 PPFIA1 PCLO	4.83e-04	141	54	4	GO:0048786
GeneOntologyCellularComponent	CHD-type complex	CHD5 CHD3	8.69e-04	17	54	2	GO:0090545
GeneOntologyCellularComponent	Ino80 complex	GON4L YY1AP1	8.69e-04	17	54	2	GO:0031011
GeneOntologyCellularComponent	NuRD complex	CHD5 CHD3	8.69e-04	17	54	2	GO:0016581
GeneOntologyCellularComponent	extrinsic component of presynaptic membrane	STXBP1 SNAP91	9.76e-04	18	54	2	GO:0098888
GeneOntologyCellularComponent	presynaptic active zone cytoplasmic component	STXBP1 PCLO	1.60e-03	23	54	2	GO:0098831
GeneOntologyCellularComponent	axon	FKBP15 TSHZ3 STXBP1 SNAP91 PPFIA1 PCLO HCFC1 EXOC8	1.93e-03	891	54	8	GO:0030424
GeneOntologyCellularComponent	INO80-type complex	GON4L YY1AP1	2.37e-03	28	54	2	GO:0097346
GeneOntologyCellularComponent	nuclear protein-containing complex	ARID1B CHD5 BARD1 GON4L YY1AP1 CHD3 TAF9 EXOSC2 ATF6B HCFC1	2.49e-03	1377	54	10	GO:0140513
GeneOntologyCellularComponent	cell cortex	HIP1 STXBP1 PCLO FGB EXOC8	2.66e-03	371	54	5	GO:0005938
GeneOntologyCellularComponent	excitatory synapse	STXBP1 SNAP91 PCLO	2.68e-03	107	54	3	GO:0060076
GeneOntologyCellularComponent	inhibitory synapse	GPHN PCLO	2.90e-03	31	54	2	GO:0060077
GeneOntologyCellularComponent	MLL1 complex	TAF9 HCFC1	3.09e-03	32	54	2	GO:0071339
GeneOntologyCellularComponent	MLL1/2 complex	TAF9 HCFC1	3.29e-03	33	54	2	GO:0044665
GeneOntologyCellularComponent	growth cone	FKBP15 TSHZ3 PCLO EXOC8	3.68e-03	245	54	4	GO:0030426
GeneOntologyCellularComponent	extrinsic component of synaptic membrane	STXBP1 SNAP91	3.69e-03	35	54	2	GO:0099243
GeneOntologyCellularComponent	site of polarized growth	FKBP15 TSHZ3 PCLO EXOC8	4.12e-03	253	54	4	GO:0030427
GeneOntologyCellularComponent	chromatin	TSHZ3 ARID1B CHD5 GON4L YY1AP1 CHD3 ZMIZ1 TAF9 ATF6B HCFC1	4.18e-03	1480	54	10	GO:0000785
GeneOntologyCellularComponent	nuclear speck	EIF4ENIF1 CHD5 ZNF638 BARD1 NCBP3	5.02e-03	431	54	5	GO:0016607
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	TDRD5 EIF4ENIF1 RBPMS2 BARD1	5.12e-03	269	54	4	GO:0036464
GeneOntologyCellularComponent	distal axon	FKBP15 TSHZ3 SNAP91 PCLO EXOC8	5.22e-03	435	54	5	GO:0150034
GeneOntologyCellularComponent	extrinsic component of plasma membrane	GPHN STXBP1 SNAP91	5.35e-03	137	54	3	GO:0019897
HumanPheno	Delayed CNS myelination	ARID1B STXBP1 ZMIZ1 YME1L1 EXOSC2 HCFC1 EXOC8	9.12e-06	199	21	7	HP:0002188
MousePheno	increased salivary adenocarcinoma incidence	GON4L YY1AP1	9.24e-06	2	43	2	MP:0000621
MousePheno	increased salivary gland tumor incidence	GON4L YY1AP1	9.19e-05	5	43	2	MP:0010318
MousePheno	increased mouth tumor incidence	GON4L YY1AP1	1.38e-04	6	43	2	MP:0003750
MousePheno	increased facial tumor incidence	GON4L YY1AP1	1.92e-04	7	43	2	MP:0008018
Domain	CHDCT2	CHD5 CHD3	2.19e-05	3	51	2	PF08074
Domain	CHDNT	CHD5 CHD3	2.19e-05	3	51	2	PF08073
Domain	DUF1086	CHD5 CHD3	2.19e-05	3	51	2	IPR009462
Domain	DUF1087	CHD5 CHD3	2.19e-05	3	51	2	IPR009463
Domain	CHD_N	CHD5 CHD3	2.19e-05	3	51	2	IPR012958
Domain	CHD_C2	CHD5 CHD3	2.19e-05	3	51	2	IPR012957
Domain	DUF1087	CHD5 CHD3	2.19e-05	3	51	2	PF06465
Domain	DUF1086	CHD5 CHD3	2.19e-05	3	51	2	PF06461
Domain	DUF1087	CHD5 CHD3	2.19e-05	3	51	2	SM01147
Domain	DUF1086	CHD5 CHD3	2.19e-05	3	51	2	SM01146
Domain	ANTH_dom	HIP1 SNAP91	4.37e-05	4	51	2	IPR011417
Domain	ANTH	HIP1 SNAP91	4.37e-05	4	51	2	PF07651
Domain	ENTH	HIP1 SNAP91	2.60e-04	9	51	2	PS50942
Domain	ENTH	HIP1 SNAP91	2.60e-04	9	51	2	SM00273
Domain	ENTH	HIP1 SNAP91	3.24e-04	10	51	2	IPR013809
Domain	Znf_C2H2_matrin	ZNF638 ZNF385B	4.74e-04	12	51	2	IPR000690
Domain	ZF_MATRIN	ZNF638 ZNF385B	1.09e-03	18	51	2	PS50171
Domain	Znf_C2H2_jaz	ZNF638 ZNF385B	1.63e-03	22	51	2	IPR022755
Domain	zf-C2H2_jaz	ZNF638 ZNF385B	1.63e-03	22	51	2	PF12171
Domain	Chromo_domain	CHD5 CHD3	1.94e-03	24	51	2	IPR023780
Domain	-	HIP1 SNAP91	2.28e-03	26	51	2	1.25.40.90
Domain	Chromo	CHD5 CHD3	2.28e-03	26	51	2	PF00385
Domain	CHROMO_1	CHD5 CHD3	2.64e-03	28	51	2	PS00598
Domain	CHROMO_2	CHD5 CHD3	2.64e-03	28	51	2	PS50013
Domain	ZnF_U1	ZNF638 ZNF385B	2.83e-03	29	51	2	SM00451
Domain	Znf_U1	ZNF638 ZNF385B	2.83e-03	29	51	2	IPR003604
Domain	ENTH_VHS	HIP1 SNAP91	2.83e-03	29	51	2	IPR008942
Domain	SNF2_N	CHD5 CHD3	3.44e-03	32	51	2	IPR000330
Domain	Chromodomain-like	CHD5 CHD3	3.44e-03	32	51	2	IPR016197
Domain	SNF2_N	CHD5 CHD3	3.44e-03	32	51	2	PF00176
Domain	Chromo/shadow_dom	CHD5 CHD3	3.66e-03	33	51	2	IPR000953
Domain	CHROMO	CHD5 CHD3	3.66e-03	33	51	2	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	CHD5 CHD3	4.11e-03	35	51	2	IPR002464
Domain	DEAH_ATP_HELICASE	CHD5 CHD3	4.83e-03	38	51	2	PS00690
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	FSIP2 TSHZ3 SBNO1 CHD5 MASTL BARD1 CHD3 EXOSC2 HCFC1 NCBP3	4.28e-08	608	56	10	36089195
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FNDC3B NEMF ZNF638 GON4L YY1AP1 CHD3 HCFC1 DENND3 EXOC8	9.12e-07	650	56	9	38777146
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	ARID1B SBNO1 ZNF638 YY1AP1 CHD3 HCFC1 NCBP3	1.26e-06	341	56	7	32971831
Pubmed	Human transcription factor protein interaction networks.	TSHZ3 NOL4L ARID1B EIF4ENIF1 CHD5 ZNF638 GON4L YY1AP1 CHD3 ZMIZ1 TAF9 HCFC1	2.31e-06	1429	56	12	35140242
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	EEF2 STXBP1 TESMIN PCDHGC4 SNAP91 SBNO1 AHNAK PPFIA1 PCLO CHD5 CAGE1 CHD3	2.53e-06	1442	56	12	35575683
Pubmed	The transcriptional regulator GON4L is required for viability and hematopoiesis in mice.	GON4L YY1AP1	2.55e-06	2	56	2	33864850
Pubmed	The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis.	GON4L YY1AP1	2.55e-06	2	56	2	20530203
Pubmed	Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity.	EEF2 RBPMS2	2.55e-06	2	56	2	25064856
Pubmed	Newly identified Gon4l/Udu-interacting proteins implicate novel functions.	GON4L YY1AP1	2.55e-06	2	56	2	32848183
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	FNDC3B HIP1 EIF4ENIF1 ATP13A1 SCOC PPFIA1 GON4L CRYBG1 TAF9 YME1L1 EXOSC2 NDUFS2	3.72e-06	1497	56	12	31527615
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TSHZ3 NOL4L EIF4ENIF1 AHNAK PPFIA1 CHD3 ZMIZ1	4.81e-06	418	56	7	34709266
Pubmed	Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division.	GON4L YY1AP1	7.63e-06	3	56	2	28381640
Pubmed	The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation.	GON4L YY1AP1	7.63e-06	3	56	2	23608756
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	AHNAK ZNF638 TAF9 HCFC1	1.16e-05	86	56	4	37253089
Pubmed	The synaptic vesicle cycle.	STXBP1 PPFIA1 PCLO	1.72e-05	31	56	3	15217342
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EEF2 ARID1B SNAP91 AHNAK ZNF638 CHD3 TAF9 HCFC1 NCBP3	2.02e-05	954	56	9	36373674
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	FKBP15 ARID1B EIF4ENIF1 ATP13A1 PPFIA1 MASTL ZNF638 HCFC1	2.18e-05	733	56	8	34672954
Pubmed	The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.	GON4L YY1AP1	2.54e-05	5	56	2	21454521
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	NOL4L CHD5 CHD3	3.20e-05	38	56	3	33283408
Pubmed	The NECAP PHear domain increases clathrin accessory protein binding potential.	HIP1 SNAP91	3.80e-05	6	56	2	17762867
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TSHZ3 ARID1B PCLO GON4L YY1AP1 EXOSC2	4.33e-05	398	56	6	35016035
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	GPHN FKBP15 EIF4ENIF1 SBNO1 AHNAK ZNF638 YME1L1 EXOSC2 NDUFS2 EXOC8	4.38e-05	1321	56	10	27173435
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	FSIP2 ARID1B EIF4ENIF1 HCFC1	4.75e-05	123	56	4	26912792
Pubmed	Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation.	TAF9 HCFC1	5.32e-05	7	56	2	7597030
Pubmed	The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence.	EEF2 YME1L1 NDUFS2	5.35e-05	45	56	3	27512140
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	ARID1B CAGE1 HCFC1 GOLGA6L1	5.54e-05	128	56	4	23858473
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	SBNO1 AHNAK PPFIA1 ZNF638	5.89e-05	130	56	4	35545047
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	EEF2 STXBP1 SNAP91 ATP13A1 PCLO SETBP1 NDUFS2	6.08e-05	621	56	7	22794259
Pubmed	Divergent hTAFII31-binding motifs hidden in activation domains.	TAF9 HCFC1	7.09e-05	8	56	2	10821850
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	AHNAK CHD5 ZNF638 CHD3 HCFC1	7.64e-05	271	56	5	32433965
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	EEF2 AHNAK ZNF638 BARD1 EXOSC2 HCFC1 NDUFS2	8.24e-05	652	56	7	31180492
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	GPHN STXBP1 AHNAK PPFIA1 PCLO	9.06e-05	281	56	5	28706196
Pubmed	Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation.	HIP1 STXBP1 PCLO	9.25e-05	54	56	3	25496667
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	FNDC3B ARID1B EIF4ENIF1 ATP13A1 ZNF638 ZMIZ1	9.28e-05	457	56	6	32344865
Pubmed	Defining the membrane proteome of NK cells.	FKBP15 EEF2 EIF4ENIF1 ATP13A1 AHNAK CHD5 YME1L1 HCFC1 EXOC8	9.65e-05	1168	56	9	19946888
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	AHNAK ZNF638 CRYBG1 CHD3 HCFC1 NCBP3	1.07e-04	469	56	6	27634302
Pubmed	Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.	GPHN STXBP1 PCLO	1.76e-04	67	56	3	16987237
Pubmed	A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein.	RBPMS2 YY1AP1	1.96e-04	13	56	2	17986458
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EEF2 AHNAK ZNF638 CHD3 HCFC1	1.97e-04	332	56	5	32786267
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	FKBP15 EEF2 SBNO1 AHNAK CHD3 TAF9 EXOSC2 HCFC1	2.09e-04	1014	56	8	32416067
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	ARID1B SBNO1 YY1AP1 TAF9 HCFC1	2.17e-04	339	56	5	30415952
Pubmed	O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.	PCLO HCFC1	2.29e-04	14	56	2	16452088
Pubmed	A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.	HIP1 BARD1 CHD3	2.46e-04	75	56	3	15383276
Pubmed	DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.	CHD5 CHD3	2.64e-04	15	56	2	35695185
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	EEF2 ATP13A1 AHNAK PPFIA1 NEMF CHD3 TAF9 HCFC1 NCBP3	3.19e-04	1371	56	9	36244648
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	FKBP15 EEF2 ZNF638 CHD3	3.20e-04	202	56	4	24639526
Pubmed	ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.	GPHN SNAP91 PCLO NDUFS2	3.20e-04	202	56	4	33601422
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	FKBP15 EEF2 ARID1B NEMF ZNF638 TAF9 EXOSC2 NDUFS2	3.23e-04	1082	56	8	38697112
Pubmed	A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.	CHD5 CHD3	3.41e-04	17	56	2	27806305
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIP1 CYREN EIF4ENIF1 ATP13A1 PCNX4 AHNAK CHD5 HCFC1	3.72e-04	1105	56	8	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ARID1B EIF4ENIF1 PPFIA1 CHD5 FGB CHD3 TAF9 YME1L1	3.97e-04	1116	56	8	31753913
Pubmed	An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.	CHD5 CHD3 HCFC1	4.34e-04	91	56	3	20362542
Pubmed	mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.	STXBP1 PPFIA1	4.75e-04	20	56	2	23791195
Pubmed	Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.	GPHN EEF2 STXBP1 SNAP91 NDUFS2	4.79e-04	403	56	5	30562941
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	STXBP1 BARD1 CHD3 HCFC1 NCBP3	5.18e-04	410	56	5	26949251
Pubmed	ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.	CHD3 TAF9	5.24e-04	21	56	2	12453419
Pubmed	Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.	EEF2 AHNAK	5.24e-04	21	56	2	30503554
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	GPHN EEF2 PCLO FGB	5.31e-04	231	56	4	16452087
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	EEF2 AHNAK PPFIA1 GON4L	5.58e-04	234	56	4	36243803
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	FKBP15 HIP1 STXBP1 PPFIA1 NCBP3	5.71e-04	419	56	5	33001583
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TESMIN PCNX4 SETBP1 NEMF ZNF638 BARD1 CHD3 ZNF385B ZMIZ1	5.81e-04	1489	56	9	28611215
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	TSHZ3 CHD5 CHD3	6.24e-04	103	56	3	32744500
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	GPHN EEF2 SBNO1 NEMF CHD3 NCBP3	6.27e-04	653	56	6	33742100
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	EIF4ENIF1 SBNO1 AHNAK YME1L1	6.32e-04	242	56	4	34011540
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TSHZ3 EIF4ENIF1 CHD5 SETBP1 PTPN22	6.42e-04	430	56	5	35044719
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	GPHN FKBP15 AHNAK MASTL ZNF638 CHD3 HCFC1	7.27e-04	934	56	7	33916271
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	SBNO1 AHNAK MASTL TAF9 HCFC1	7.42e-04	444	56	5	34795231
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	EIF4ENIF1 AHNAK CHD3 HCFC1	7.80e-04	256	56	4	33397691
Pubmed	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.	STXBP1 PPFIA1	8.07e-04	26	56	2	17124501
Pubmed	Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.	GPHN STXBP1	8.71e-04	27	56	2	19723784
Pubmed	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	AHNAK FGB	8.71e-04	27	56	2	23144326
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	EEF2 SETMAR STXBP1 SBNO1 ATP13A1 NEMF YY1AP1 YME1L1	9.98e-04	1285	56	8	35914814
Pubmed	Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.	STXBP1 PPFIA1	1.08e-03	30	56	2	16186258
Pubmed	Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.	TAF9 HCFC1	1.15e-03	31	56	2	15960975
Pubmed	miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network.	STXBP1 PCLO	1.15e-03	31	56	2	37816598
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	PPFIA1 FGB PTPN22 HCFC1 NCBP3	1.22e-03	497	56	5	36774506
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	TSHZ3 EEF2 ZNF638 CHD3 YME1L1 EXOSC2 HCFC1 NDUFS2	1.27e-03	1335	56	8	29229926
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	GPHN EEF2 MASTL ZNF638 HCFC1	1.29e-03	503	56	5	16964243
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	GPHN FKBP15 SBNO1 ATP13A1 RBPMS2 EXOSC2	1.32e-03	754	56	6	33060197
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	ARID1B TAF9 HCFC1	1.34e-03	134	56	3	25452129
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	NEMF BARD1 CHD3 YME1L1 EXOSC2 NCBP3	1.36e-03	759	56	6	35915203
Pubmed	Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.	FNDC3B ZNF638 ZMIZ1	1.39e-03	136	56	3	25429064
Pubmed	Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.	EEF2 AHNAK HCFC1	1.42e-03	137	56	3	37039823
Pubmed	Identification of the BRD1 interaction network and its impact on mental disorder risk.	CHD5 CHD3	1.46e-03	35	56	2	27142060
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EEF2 NOL4L ZNF638 YY1AP1 CHD3 EXOSC2	1.50e-03	774	56	6	15302935
Cytoband	10p14	ERVK-16 YME1L1	4.66e-04	26	56	2	10p14
Cytoband	1p13.2	PTPN22 ST7L	1.46e-03	46	56	2	1p13.2
Cytoband	1q22	GON4L YY1AP1	2.23e-03	57	56	2	1q22
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	GON4L YY1AP1	3.44e-03	71	56	2	chr1q22
GeneFamily	PHD finger proteins\|NuRD complex	CHD5 CHD3	1.40e-04	12	27	2	1305
Coexpression	MURARO_PANCREAS_BETA_CELL	TSHZ3 EEF2 STXBP1 SNAP91 SBNO1 PCLO SETBP1 ZMIZ1 TAF9 YME1L1	2.39e-05	946	55	10	M39169
Coexpression	GSE21678_WT_VS_FOXO1_FOXO3_KO_TREG_UP	GPHN HIP1 ARID1B MASTL CRYBG1	5.30e-05	193	55	5	M7395
Coexpression	GSE3982_BASOPHIL_VS_TH1_DN	FNDC3B EEF2 STXBP1 PPFIA1 HCFC1	6.13e-05	199	55	5	M5565
Coexpression	GSE11961_MEMORY_BCELL_DAY7_VS_GERMINAL_CENTER_BCELL_DAY7_UP	TSHZ3 SNAP91 SCOC AHNAK CRYBG1	6.28e-05	200	55	5	M9319
Coexpression	WANG_LSD1_TARGETS_DN	STXBP1 PCLO EXOC8	6.46e-05	37	55	3	M1760
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP1 SNAP91 PCLO CHD5 SETBP1 ZNF385B	1.54e-07	196	55	6	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP1 SNAP91 PCLO CHD5 SETBP1 ZNF385B	1.63e-07	198	55	6	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP1 SNAP91 PCLO CHD5 SETBP1 ZNF385B	1.63e-07	198	55	6	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP1 SNAP91 PCLO CHD5 SETBP1 ZNF385B	1.63e-07	198	55	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP1 SNAP91 PCLO CHD5 SETBP1 ZNF385B	1.63e-07	198	55	6	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STXBP1 SNAP91 PCLO CHD5 SETBP1 ZNF385B	1.63e-07	198	55	6	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	STXBP1 SNAP91 PCLO CHD5 SETBP1 ZNF385B	1.73e-07	200	55	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon\|organoid_Paulsen_bioRxiv / Sample Type, Dataset, Time_group, and Cell type.	EEF2 STXBP1 SBNO1 PCLO ATF6B	4.13e-06	194	55	5	4903a0d6e36599bcb83b179462e5b949df9eb685
ToppCell	Frontal_cortex-Neuronal\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	STXBP1 SNAP91 PCLO CHD5 ZNF385B	4.68e-06	199	55	5	f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TDRD5 TESMIN SNAP91 PCLO	1.90e-05	128	55	4	2cf0384240a4a663869cf6b27d954236f6214a9a
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSHZ3 NOL4L AHNAK PTPN22	4.45e-05	159	55	4	d2de9391b00b6c47f5fe28a1bad6da2097107ee0
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSHZ3 NOL4L AHNAK PTPN22	4.45e-05	159	55	4	da6b7f8039adc19839d6c090a0b3d68fb6445a79
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARID1B CRYBG1 CHD3 C4orf54	5.77e-05	170	55	4	928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP1 SNAP91 PCLO ZNF385B	5.91e-05	171	55	4	99176a932569fa1c7e1c01009684f5a65244b96e
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	NOL4L PCNX4 AHNAK NCBP3	7.68e-05	183	55	4	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP1 SNAP91 PCLO ZNF385B	7.85e-05	184	55	4	7d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP1 SNAP91 PCLO ZNF385B	8.35e-05	187	55	4	1b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	GPHN FNDC3B ARID1B SETBP1	9.25e-05	192	55	4	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	STXBP1 SNAP91 PCLO CHD5	9.62e-05	194	55	4	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	COVID-19_Mild-PLT_5\|COVID-19_Mild / Disease Group and Platelet Clusters	FNDC3B FKBP15 EEF2 AHNAK	9.82e-05	195	55	4	bdf9a6ea1bd83c72a834c45f86ce3f4643a9bef3
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	STXBP1 PCLO CHD5 CHD3	1.06e-04	199	55	4	77b4aa00f14b86ef5db0490be98787e063979541
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	STXBP1 SNAP91 CHD5 ZNF385B	1.08e-04	200	55	4	2f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	STXBP1 SNAP91 CHD5 ZNF385B	1.08e-04	200	55	4	dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCell	Neuronal-Excitatory-eC(RORB)-ESR1--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TSHZ3 STXBP1 PCLO BARD1	1.08e-04	200	55	4	32231471987dd5647c9f7c430ff62dc366b5aea8
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	STXBP1 SNAP91 CHD5 ZNF385B	1.08e-04	200	55	4	bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCell	Neuronal-Excitatory-eC(RORB)-ESR1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TSHZ3 STXBP1 PCLO BARD1	1.08e-04	200	55	4	82caaee79e697ed4ddea7dd49e99b7abe849604f
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal\|6m / Sample Type, Dataset, Time_group, and Cell type.	STXBP1 SNAP91 PCLO CHD5	1.08e-04	200	55	4	cedbc47b1defb5973cf7ab6baaa2d6f2fd481f88
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Cortical_neuron\|6m / Sample Type, Dataset, Time_group, and Cell type.	STXBP1 SNAP91 PCLO CHD5	1.08e-04	200	55	4	6f7ff0533339fcc9d316f2c77334a79c1409ec4f
ToppCell	Neuronal-Excitatory-eC(RORB)-ESR1---L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TSHZ3 STXBP1 PCLO BARD1	1.08e-04	200	55	4	622ca21b7949ec3d40e17ea08ce4212bbfb963db
ToppCell	Neuronal-Excitatory-eC(RORB)-ESR1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TSHZ3 STXBP1 PCLO BARD1	1.08e-04	200	55	4	0d559f7d8bfd24bcdc770fe2f3baebfddda9b640
Disease	salivary gland cancer (implicated_via_orthology)	GON4L YY1AP1	3.29e-06	2	54	2	DOID:8850 (implicated_via_orthology)
Disease	Neuroblastoma	ARID1B CHD5 BARD1	8.87e-05	47	54	3	C0027819
Disease	stroke	FGB CRYBG1 CHD3 C4orf54	1.42e-04	144	54	4	EFO_0000712
Disease	inherited metabolic disorder (is_implicated_in)	GPHN NDUFS2	3.40e-04	15	54	2	DOID:655 (is_implicated_in)
Disease	Neurodevelopmental Disorders	ARID1B STXBP1 SETBP1	6.69e-04	93	54	3	C1535926
Disease	Malignant neoplasm of breast	FNDC3B EEF2 ARID1B SBNO1 CHD5 SETBP1 BARD1 ZMIZ1	7.06e-04	1074	54	8	C0006142
Disease	rheumatoid arthritis, Crohn's disease	PTPN22 ZMIZ1	2.22e-03	38	54	2	EFO_0000384, EFO_0000685
Disease	sitting height ratio	ARID1B ZMIZ1	3.96e-03	51	54	2	EFO_0007118
Disease	substance-related disorder	NOL4L C4orf54	4.11e-03	52	54	2	MONDO_0002494
Disease	lymphocyte count	PCDHGC4 SBNO1 AHNAK PPFIA1 ZNF638 PTPN22 ZMIZ1 DENND3	4.90e-03	1464	54	8	EFO_0004587
Disease	Myopia	ARID1B CAGE1 ZNF385B DENND3	5.40e-03	385	54	4	HP_0000545

Protein segments in the cluster

Peptide	Gene	Start	Entry
MEPPKQIMSMEKTSK	TDRD5	246	Q8NAT2
ENHPKSMTMMPALFK	CAGE1	756	Q8TC20
RVMSSPSAMKLLPNM	BARD1	406	Q99728
NPKIPMSKMMTVLGA	CHD5	176	Q8TDI0
RNMSEIRKMGNKPHM	ATP13A1	286	Q9HD20
INMMDILTTPSMAKP	MASTL	186	Q96GX5
KSTEPKMETMRMLKP	C16orf78	196	Q8WTQ4
FKMPDMNIKAPKISM	AHNAK	3531	Q09666
RMSPSKSPFLPSMKM	ARID1B	1636	Q8NFD5
MRTMAPEKLLKSMPI	SNAP91	156	O60641
MQYLSLPKTPKMLKM	C22orf42	61	Q6IC83
KMSNEMPMTLPETTL	DENND3	861	A2RUS2
KMAKSKLMATPNPSN	RBPMS2	111	Q6ZRY4
MMSEEQMKLPSTNKA	ERVK-16	31	P61578
PNLPKSTTKAAKMMN	PTPN22	326	Q9Y2R2
MSMRSANGLLMLPPK	GPHN	701	Q9NQX3
VAPMKAPKRMRMAAV	CYREN	26	Q9BWK5
RPMSSPEMKSAPKKS	HCFC1	2016	P51610
PKNMMPSSFAMKCRK	NEMF	66	O60524
MMRKPSSDKIPSIDK	FSIP2	5896	Q5CZC0
SMRKMSMKIRPFFPQ	FGB	476	P02675
PASPKTAKMMQRSMS	PCLO	3666	Q9Y6V0
TAKMMQRSMSDPKPL	PCLO	3671	Q9Y6V0
MPSSKMKEMSSLFPE	PCNX4	921	Q63HM2
KAKLISRMAKMGQPM	FKBP15	361	Q5T1M5
ISTPSPKKSMKMTMY	NCBP3	411	Q53F19
VTSSMSSPSMQPKKM	PPFIA1	1166	Q13136
PTHPMMSKETRQSKL	GOLGA6L1	46	Q8N7Z2
RSDSFMMVKSPSAPM	PCDHGC4	781	Q9Y5F7
RRMKKNGMEMTRPTP	NOL4L	246	Q96MY1
MAMEMRLPVARKPLS	EXOSC2	1	Q13868
PMKDMFKLLMFPESR	EXOC8	246	Q8IYI6
AKVSPPKRAEMKTSM	NDUFS2	361	O75306
MTPMRKTNPLMKLIN	MT-CYB	1	P00156
KNPKIPMSKMMTILG	CHD3	176	Q12873
MGSLDDPKMKSMMPT	FNDC3B	1161	Q53EP0
EDMPMFEPKMTRSKL	GON4L	316	Q3T8J9
QESSGMMKLFMPRPK	DSCR8	71	Q96T75
KGPLMMYISKMVPTS	EEF2	391	P13639
VCMPMKRKKARMPNS	CRYBG1	711	Q9Y4K1
KRKSDPLPMMMDSHV	C4orf54	1276	D6RIA3
NDMKMRSFSPTMKVP	SBNO1	206	A3KN83
SPERKTLMSMPNYMQ	TESMIN	406	Q9Y4I5
TASPKSMPKDAQMMA	TAF9	6	Q16594
MDRMASSMKQVPNPL	HIP1	1	O00291
FPSCKRLTLETMKMM	SETMAR	331	Q53H47
PKSLLPKMMNADMDA	SCOC	71	Q9UIL1
KTTMRDLSQMLKKMP	STXBP1	321	P61764
MRKPMSPITAQMSQL	EIF4ENIF1	606	Q9NRA8
KTSRPKMSLVMPAMA	ATF6B	611	Q99941
MRDLMKEFPPLTMLN	ST7L	316	Q8TDW4
TLMMQPSLDIKPFMS	ZNF385B	101	Q569K4
PMSMLFKMSNSLAEK	TSHZ3	746	Q63HK5
KVMMPSPASSMFRKP	YY1AP1	556	Q9H869
RSMFMEPAKRMKKSL	YME1L1	81	Q96TA2
KPKPSTMLREAVMAT	SETBP1	536	Q9Y6X0
DRMTSTMHKMLSLPP	UHRF1BP1	1056	Q6BDS2
AQKMKRLPTPSMMND	ZNF638	401	Q14966
PSKRFKTMSPSQMIM	ZMIZ1	841	Q9ULJ6