Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnon-membrane spanning protein tyrosine kinase activity

SRMS FYN ZAP70 SRC

6.46e-0746304GO:0004715
GeneOntologyMolecularFunctionubiquitin protein ligase activity

TRIM49 PELI1 TRAF6 TRIM49B RNF126 TRIM51G TRIM49C

1.04e-06372307GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

TRIM49 PELI1 TRAF6 TRIM49B RNF126 TRIM51G TRIM49C

1.62e-06398307GO:0061659
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

SRMS FYN ZAP70 NTRK1 SRC

2.32e-06145305GO:0004713
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

TRIM49 PELI1 TRAF6 TRIM49B RNF126 TRIM51G TRIM49C

5.08e-06473307GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

TRIM49 PELI1 TRAF6 TRIM49B RNF126 TRIM51G TRIM49C

8.53e-06512307GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

TRIM49 PELI1 TRAF6 TRIM49B RNF126 TRIM51G TRIM49C

1.09e-05532307GO:0016755
GeneOntologyMolecularFunctionacyltransferase activity

TRIM49 PELI1 TRAF6 TRIM49B RNF126 TRIM51G TRIM49C

1.20e-04775307GO:0016746
GeneOntologyMolecularFunctionubiquitin-ubiquitin ligase activity

PELI1 TRAF6

1.96e-0414302GO:0034450
GeneOntologyMolecularFunctionphospholipase activator activity

FYN SRC

5.41e-0423302GO:0016004
GeneOntologyMolecularFunctiongap junction channel activity

GJA4 GJB4

6.41e-0425302GO:0005243
GeneOntologyMolecularFunctionlipase activator activity

FYN SRC

7.48e-0427302GO:0060229
GeneOntologyMolecularFunctionephrin receptor binding

FYN SRC

1.05e-0332302GO:0046875
GeneOntologyMolecularFunctionphospholipase binding

FYN SRC

1.05e-0332302GO:0043274
GeneOntologyMolecularFunctionwide pore channel activity

GJA4 GJB4

1.41e-0337302GO:0022829
GeneOntologyMolecularFunctionprotein kinase activity

SRMS FYN ZAP70 NTRK1 SRC

1.84e-03600305GO:0004672
GeneOntologyMolecularFunctionkinase binding

TRIM49 TRAF6 TRIM49B NTRK1 SRC TRIM49C

2.80e-03969306GO:0019900
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

SRMS FYN ZAP70 NTRK1 SRC

3.79e-03709305GO:0016773
GeneOntologyMolecularFunctionkinase activity

SRMS FYN ZAP70 NTRK1 SRC

5.21e-03764305GO:0016301
GeneOntologyBiologicalProcessinnate immune response

SRMS TRIM49 PELI1 TRAF6 FYN TRIM49B IFIT1 ZAP70 TRIM51G SRC TRIM49C

1.88e-0710923011GO:0045087
GeneOntologyBiologicalProcessdefense response to symbiont

SRMS TRIM49 PELI1 TRAF6 FYN TRIM49B IFIT1 ZAP70 TRIM51G SRC TRIM49C

9.62e-0712863011GO:0140546
GeneOntologyBiologicalProcessdefense response to other organism

SRMS TRIM49 PELI1 TRAF6 FYN TRIM49B IFIT1 ZAP70 TRIM51G SRC TRIM49C

2.33e-0614073011GO:0098542
GeneOntologyBiologicalProcessstimulatory C-type lectin receptor signaling pathway

TRAF6 FYN SRC

4.82e-0623303GO:0002223
GeneOntologyBiologicalProcesscellular response to lectin

TRAF6 FYN SRC

4.82e-0623303GO:1990858
GeneOntologyBiologicalProcessresponse to lectin

TRAF6 FYN SRC

4.82e-0623303GO:1990840
GeneOntologyBiologicalProcesstoll-like receptor 3 signaling pathway

PELI1 TRAF6 SRC

1.21e-0531303GO:0034138
GeneOntologyBiologicalProcessprotein ubiquitination

TRIM49 PELI1 TRAF6 FYN TRIM49B RNF126 TRIM51G TRIM49C

1.50e-05811308GO:0016567
GeneOntologyBiologicalProcessinnate immune response activating cell surface receptor signaling pathway

PELI1 TRAF6 FYN SRC

1.69e-05107304GO:0002220
GeneOntologyBiologicalProcessprotein autophosphorylation

SRMS FYN ZAP70 NTRK1 SRC

1.80e-05228305GO:0046777
GeneOntologyBiologicalProcessprotein modification by small protein conjugation

TRIM49 PELI1 TRAF6 FYN TRIM49B RNF126 TRIM51G TRIM49C

2.99e-05893308GO:0032446
GeneOntologyBiologicalProcessephrin receptor signaling pathway

FYN NTRK1 SRC

6.55e-0554303GO:0048013
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

TRIM49 PELI1 TRAF6 FYN TRIM49B RNF126 TRIM51G TRIM49C

7.12e-051009308GO:0070647
GeneOntologyBiologicalProcessendolysosomal toll-like receptor signaling pathway

PELI1 TRAF6 SRC

7.31e-0556303GO:0140894
GeneOntologyBiologicalProcessFc receptor signaling pathway

TRAF6 FYN SRC

9.91e-0562303GO:0038093
GeneOntologyBiologicalProcesspeptidyl-tyrosine phosphorylation

SRMS FYN ZAP70 NTRK1 SRC

9.99e-05327305GO:0018108
GeneOntologyBiologicalProcesspeptidyl-tyrosine modification

SRMS FYN ZAP70 NTRK1 SRC

1.03e-04329305GO:0018212
GeneOntologyBiologicalProcesspost-translational protein modification

TRIM49 PELI1 TRAF6 FYN TRIM49B RNF126 TRIM51G TRIM49C

1.10e-041074308GO:0043687
GeneOntologyBiologicalProcessimmune response-activating cell surface receptor signaling pathway

PELI1 TRAF6 FYN ZAP70 SRC

1.55e-04359305GO:0002429
GeneOntologyBiologicalProcessprotein K63-linked ubiquitination

PELI1 TRAF6 RNF126

1.82e-0476303GO:0070534
GeneOntologyBiologicalProcessregulation of toll-like receptor 3 signaling pathway

PELI1 SRC

1.84e-0414302GO:0034139
GeneOntologyBiologicalProcesspositive regulation of lymphocyte activation

PELI1 TRAF6 FYN ZAP70 SRC

2.14e-04385305GO:0051251
GeneOntologyBiologicalProcessimmune response-regulating cell surface receptor signaling pathway

PELI1 TRAF6 FYN ZAP70 SRC

2.36e-04393305GO:0002768
GeneOntologyBiologicalProcesspositive regulation of leukocyte activation

PELI1 TRAF6 FYN ZAP70 SRC

3.31e-04423305GO:0002696
GeneOntologyBiologicalProcessregulation of leukocyte cell-cell adhesion

PELI1 TRAF6 FYN ZAP70 SRC

4.26e-04447305GO:1903037
GeneOntologyBiologicalProcessregulation of TORC1 signaling

SRMS PELI1 SRC

4.33e-04102303GO:1903432
GeneOntologyBiologicalProcesspositive regulation of cell activation

PELI1 TRAF6 FYN ZAP70 SRC

4.35e-04449305GO:0050867
GeneOntologyBiologicalProcessosteoclast development

FBN1 SRC

4.64e-0422302GO:0036035
GeneOntologyBiologicalProcessbone cell development

FBN1 SRC

4.64e-0422302GO:0098751
GeneOntologyBiologicalProcesspeptidyl-tyrosine autophosphorylation

SRMS NTRK1

4.64e-0422302GO:0038083
GeneOntologyBiologicalProcessregulation of T cell activation

PELI1 TRAF6 FYN ZAP70 SRC

4.76e-04458305GO:0050863
GeneOntologyBiologicalProcessTORC1 signaling

SRMS PELI1 SRC

5.25e-04109303GO:0038202
GeneOntologyBiologicalProcessnegative regulation of necroptotic process

PELI1 ADPRS

5.53e-0424302GO:0060546
GeneOntologyBiologicalProcessimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis

FYN SRC

6.01e-0425302GO:0002433
GeneOntologyBiologicalProcessFc-gamma receptor signaling pathway involved in phagocytosis

FYN SRC

6.01e-0425302GO:0038096
GeneOntologyBiologicalProcesspositive regulation of Ras protein signal transduction

NTRK1 SRC

6.01e-0425302GO:0046579
GeneOntologyBiologicalProcessleukocyte cell-cell adhesion

PELI1 TRAF6 FYN ZAP70 SRC

6.23e-04486305GO:0007159
GeneOntologyBiologicalProcesscell surface receptor protein tyrosine kinase signaling pathway

SRMS FYN RNF126 ZAP70 NTRK1 SRC

6.24e-04747306GO:0007169
GeneOntologyBiologicalProcessnegative regulation of programmed necrotic cell death

PELI1 ADPRS

6.50e-0426302GO:0062099
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception of pain

FYN NTRK1

6.50e-0426302GO:0050966
GeneOntologyBiologicalProcesscellular response to platelet-derived growth factor stimulus

FYN SRC

7.55e-0428302GO:0036120
GeneOntologyBiologicalProcessT cell proliferation

PELI1 TRAF6 FYN ZAP70

7.66e-04288304GO:0042098
GeneOntologyBiologicalProcesspositive regulation of T cell activation

TRAF6 FYN ZAP70 SRC

7.86e-04290304GO:0050870
GeneOntologyBiologicalProcessskeletal muscle cell proliferation

SRC KPNA1

8.10e-0429302GO:0014856
GeneOntologyBiologicalProcessresponse to platelet-derived growth factor

FYN SRC

9.26e-0431302GO:0036119
GeneOntologyBiologicalProcesschemosensory behavior

GJB4 NTRK1

9.26e-0431302GO:0007635
GeneOntologyBiologicalProcessinnate immune response-activating signaling pathway

PELI1 TRAF6 FYN SRC

1.03e-03312304GO:0002758
GeneOntologyBiologicalProcesspositive regulation of leukocyte cell-cell adhesion

TRAF6 FYN ZAP70 SRC

1.09e-03317304GO:1903039
GeneOntologyBiologicalProcessimmune response-activating signaling pathway

PELI1 TRAF6 FYN ZAP70 SRC

1.11e-03553305GO:0002757
GeneOntologyBiologicalProcessneurotrophin TRK receptor signaling pathway

NTRK1 SRC

1.11e-0334302GO:0048011
GeneOntologyBiologicalProcessFc receptor mediated stimulatory signaling pathway

FYN SRC

1.18e-0335302GO:0002431
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

SRMS FBN1 FYN RNF126 ZAP70 NTRK1 SRC

1.29e-031186307GO:0007167
GeneOntologyBiologicalProcessactivation of innate immune response

PELI1 TRAF6 FYN SRC

1.31e-03333304GO:0002218
GeneOntologyBiologicalProcessnegative regulation of inflammatory response to antigenic stimulus

FYN SRC

1.32e-0337302GO:0002862
GeneOntologyBiologicalProcessregulation of necroptotic process

PELI1 ADPRS

1.32e-0337302GO:0060544
GeneOntologyBiologicalProcessregulation of DNA recombination

PELI1 RNF126 KPNA1

1.33e-03150303GO:0000018
GeneOntologyBiologicalProcessregulation of cell-cell adhesion

PELI1 TRAF6 FYN ZAP70 SRC

1.38e-03580305GO:0022407
GeneOntologyBiologicalProcessFc-gamma receptor signaling pathway

FYN SRC

1.47e-0339302GO:0038094
GeneOntologyBiologicalProcessregulation of TOR signaling

SRMS PELI1 SRC

1.54e-03158303GO:0032006
GeneOntologyBiologicalProcessT cell receptor signaling pathway

TRAF6 FYN ZAP70

1.59e-03160303GO:0050852
GeneOntologyBiologicalProcessosteoclast differentiation

TRAF6 FBN1 SRC

1.65e-03162303GO:0030316
GeneOntologyBiologicalProcessregulation of lymphocyte activation

PELI1 TRAF6 FYN ZAP70 SRC

1.77e-03614305GO:0051249
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception of pain

FYN NTRK1

1.78e-0343302GO:0062149
GeneOntologyBiologicalProcessregulation of programmed necrotic cell death

PELI1 ADPRS

1.78e-0343302GO:0062098
GeneOntologyBiologicalProcessimmune response-regulating signaling pathway

PELI1 TRAF6 FYN ZAP70 SRC

1.78e-03615305GO:0002764
GeneOntologyBiologicalProcesspositive regulation of double-strand break repair via homologous recombination

PELI1 RNF126

1.86e-0344302GO:1905168
GeneOntologyBiologicalProcesspurine ribonucleotide catabolic process

NUDT19 PDE7A SRC

1.86e-03169303GO:0009154
GeneOntologyBiologicalProcessactivation of immune response

PELI1 TRAF6 FYN ZAP70 SRC

1.88e-03623305GO:0002253
GeneOntologyBiologicalProcessDNA recombination

PELI1 INTS3 RNF126 KPNA1

1.89e-03368304GO:0006310
GeneOntologyBiologicalProcesspositive regulation of lymphocyte proliferation

PELI1 TRAF6 ZAP70

1.90e-03170303GO:0050671
GeneOntologyBiologicalProcesslearning or memory

ADGRB3 FYN NTRK1 SRC

1.99e-03373304GO:0007611
GeneOntologyBiologicalProcesspositive regulation of mononuclear cell proliferation

PELI1 TRAF6 ZAP70

1.99e-03173303GO:0032946
GeneOntologyBiologicalProcesspositive regulation of protein modification process

PELI1 TRAF6 FBN1 FYN NTRK1 SRC

2.01e-03937306GO:0031401
GeneOntologyBiologicalProcessneurotrophin signaling pathway

NTRK1 SRC

2.12e-0347302GO:0038179
GeneOntologyBiologicalProcesscellular response to reactive oxygen species

ADPRS FYN SRC

2.16e-03178303GO:0034614
GeneOntologyBiologicalProcessribonucleotide catabolic process

NUDT19 PDE7A SRC

2.16e-03178303GO:0009261
GeneOntologyBiologicalProcesspositive regulation of intracellular signal transduction

SRMS PELI1 TRAF6 FYN ZAP70 NTRK1 SRC

2.18e-031299307GO:1902533
GeneOntologyBiologicalProcessTOR signaling

SRMS PELI1 SRC

2.27e-03181303GO:0031929
GeneOntologyBiologicalProcesspurine nucleotide catabolic process

NUDT19 PDE7A SRC

2.30e-03182303GO:0006195
GeneOntologyBiologicalProcesscellular response to amyloid-beta

FYN NTRK1

2.30e-0349302GO:1904646
GeneOntologyBiologicalProcesspositive regulation of cell-cell adhesion

TRAF6 FYN ZAP70 SRC

2.32e-03389304GO:0022409
GeneOntologyBiologicalProcesslymphocyte activation

PELI1 TRAF6 FYN ZAP70 NTRK1 SRC

2.47e-03976306GO:0046649
GeneOntologyBiologicalProcessresponse to pain

GJA4 NTRK1

2.49e-0351302GO:0048265
GeneOntologyBiologicalProcessT cell costimulation

FYN SRC

2.49e-0351302GO:0031295
GeneOntologyBiologicalProcesslymphocyte proliferation

PELI1 TRAF6 FYN ZAP70

2.52e-03398304GO:0046651
GeneOntologyBiologicalProcesspurine-containing compound catabolic process

NUDT19 PDE7A SRC

2.52e-03188303GO:0072523
GeneOntologyBiologicalProcessdouble-strand break repair via homologous recombination

PELI1 INTS3 RNF126

2.52e-03188303GO:0000724
GeneOntologyBiologicalProcesscytoplasmic pattern recognition receptor signaling pathway

PELI1 TRAF6 SRC

2.52e-03188303GO:0002753
GeneOntologyBiologicalProcesspositive regulation of leukocyte proliferation

PELI1 TRAF6 ZAP70

2.64e-03191303GO:0070665
GeneOntologyBiologicalProcesspositive regulation of kinase activity

TRAF6 FBN1 NTRK1 SRC

2.68e-03405304GO:0033674
GeneOntologyBiologicalProcessnecroptotic process

PELI1 ADPRS

2.69e-0353302GO:0070266
GeneOntologyBiologicalProcesslymphocyte costimulation

FYN SRC

2.69e-0353302GO:0031294
GeneOntologyBiologicalProcessmononuclear cell proliferation

PELI1 TRAF6 FYN ZAP70

2.70e-03406304GO:0032943
GeneOntologyBiologicalProcessrecombinational repair

PELI1 INTS3 RNF126

2.76e-03194303GO:0000725
GeneOntologyBiologicalProcesscell activation

PELI1 TRAF6 FYN ZAP70 NTRK1 SRC KPNA1

2.79e-031356307GO:0001775
GeneOntologyCellularComponentconnexin complex

GJA4 GJB4

4.83e-0422312GO:0005922
GeneOntologyCellularComponentsite of DNA damage

PELI1 ADPRS INTS3

1.08e-03137313GO:0090734
GeneOntologyCellularComponentextrinsic component of plasma membrane

TRAF6 ZAP70 APC2

1.08e-03137313GO:0019897
GeneOntologyCellularComponentactin filament

FYN APC2 SRC

1.30e-03146313GO:0005884
GeneOntologyCellularComponentgap junction

GJA4 GJB4

1.37e-0337312GO:0005921
MousePhenoabnormal T cell clonal deletion

FYN ZAP70

3.87e-056232MP:0005002
MousePhenoabnormal clonal deletion

FYN ZAP70

3.87e-056232MP:0005001
MousePhenoectopic hippocampus pyramidal cells

FYN APC2

5.41e-057232MP:0010011
MousePhenoabnormal olfaction

FYN GJB4 ATP6V0A4

7.25e-0550233MP:0001984
MousePhenoabnormal olfactory system physiology

FYN GJB4 ATP6V0A4

1.13e-0458233MP:0001983
MousePhenodecreased molar number

TRAF6 SRC

2.33e-0414232MP:0006400
MousePhenoabnormal negative T cell selection

FYN ZAP70

2.33e-0414232MP:0004918
MousePhenoabsent incisors

TRAF6 SRC

2.68e-0415232MP:0000125
DomainTyrKc

SRMS FYN ZAP70 NTRK1 SRC

2.69e-0788305SM00219
DomainTyr_kinase_cat_dom

SRMS FYN ZAP70 NTRK1 SRC

2.69e-0788305IPR020635
DomainPROTEIN_KINASE_TYR

SRMS FYN ZAP70 NTRK1 SRC

4.38e-0797305PS00109
DomainTyr_kinase_AS

SRMS FYN ZAP70 NTRK1 SRC

4.38e-0797305IPR008266
DomainPkinase_Tyr

SRMS FYN ZAP70 NTRK1 SRC

1.80e-06129305PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

SRMS FYN ZAP70 NTRK1 SRC

2.52e-06138305IPR001245
DomainSH2

SRMS FYN ZAP70 SRC

1.98e-05101304PF00017
DomainSH2

SRMS FYN ZAP70 SRC

2.77e-05110304SM00252
DomainSH2

SRMS FYN ZAP70 SRC

2.87e-05111304PS50001
DomainSH2

SRMS FYN ZAP70 SRC

2.98e-05112304IPR000980
Domain-

SRMS FYN ZAP70 SRC

2.98e-051123043.30.505.10
Domain-

TRIM49 TRAF6 TRIM49B RNF126 PHF12 TRIM49C

6.79e-054493063.30.40.10
DomainZnf_RING/FYVE/PHD

TRIM49 TRAF6 TRIM49B RNF126 PHF12 TRIM49C

7.67e-05459306IPR013083
DomainZF_RING_1

TRIM49 TRAF6 TRIM49B RNF126 TRIM49C

9.18e-05291305PS00518
DomainZF_RING_2

TRIM49 TRAF6 TRIM49B RNF126 TRIM49C

1.03e-04298305PS50089
DomainRING

TRIM49 TRAF6 TRIM49B RNF126 TRIM49C

1.15e-04305305SM00184
DomainZnf_RING

TRIM49 TRAF6 TRIM49B RNF126 TRIM49C

1.56e-04326305IPR001841
DomainBBOX

TRIM49 TRIM49B TRIM49C

1.82e-0469303SM00336
DomainButyrophylin

TRIM49 TRIM49B TRIM49C

1.90e-0470303IPR003879
Domain-

TRIM49 TRIM49B TRIM49C

1.99e-04713034.10.45.10
Domainzf-B_box

TRIM49 TRIM49B TRIM49C

2.07e-0472303PF00643
DomainZF_BBOX

TRIM49 TRIM49B TRIM49C

2.83e-0480303PS50119
DomainZnf_B-box

TRIM49 TRIM49B TRIM49C

2.93e-0481303IPR000315
DomainProtein_kinase_ATP_BS

SRMS FYN ZAP70 NTRK1 SRC

3.14e-04379305IPR017441
DomainSPRY

TRIM49 TRIM49B TRIM49C

3.62e-0487303SM00449
DomainCONNEXINS_1

GJA4 GJB4

4.19e-0419302PS00407
DomainSPRY

TRIM49 TRIM49B TRIM49C

4.54e-0494303PF00622
DomainSPRY_dom

TRIM49 TRIM49B TRIM49C

4.54e-0494303IPR003877
DomainConnexin_N

GJA4 GJB4

4.65e-0420302IPR013092
DomainCONNEXINS_2

GJA4 GJB4

4.65e-0420302PS00408
DomainConnexin

GJA4 GJB4

4.65e-0420302PF00029
DomainConnexin_CCC

GJA4 GJB4

4.65e-0420302SM01089
DomainConnexin_CS

GJA4 GJB4

4.65e-0420302IPR017990
DomainConnexin

GJA4 GJB4

4.65e-0420302IPR000500
DomainConnexin_CCC

GJA4 GJB4

4.65e-0420302IPR019570
DomainCNX

GJA4 GJB4

4.65e-0420302SM00037
DomainB30.2/SPRY

TRIM49 TRIM49B TRIM49C

4.69e-0495303IPR001870
DomainB302_SPRY

TRIM49 TRIM49B TRIM49C

4.69e-0495303PS50188
DomainPROTEIN_KINASE_ATP

SRMS FYN ZAP70 NTRK1 SRC

7.52e-04459305PS00107
DomainProt_kinase_dom

SRMS FYN ZAP70 NTRK1 SRC

1.00e-03489305IPR000719
DomainPROTEIN_KINASE_DOM

SRMS FYN ZAP70 NTRK1 SRC

1.04e-03493305PS50011
DomainArm

APC2 KPNA1

1.13e-0331302PF00514
DomainKinase-like_dom

SRMS FYN ZAP70 NTRK1 SRC

1.58e-03542305IPR011009
DomainARM

APC2 KPNA1

1.87e-0340302SM00185
DomainARM_REPEAT

APC2 KPNA1

1.87e-0340302PS50176
DomainArmadillo

APC2 KPNA1

2.58e-0347302IPR000225
DomainSH3

SRMS FYN SRC

4.92e-03216303PS50002
DomainSH3

SRMS FYN SRC

4.92e-03216303SM00326
DomainConA-like_dom

TRIM49 TRIM49B TRIM49C

5.11e-03219303IPR013320
DomainSH3_domain

SRMS FYN SRC

5.18e-03220303IPR001452
DomainEGF_CA

FBN1 VWCE

8.38e-0386302PF07645
DomainEGF_Ca-bd_CS

FBN1 VWCE

1.06e-0297302IPR018097
DomainEGF_CA

FBN1 VWCE

1.10e-0299302PS01187
PathwayPID_P38_ALPHA_BETA_PATHWAY

TRAF6 FYN SRC

1.30e-0530223M76
PathwayWP_NETWORK_MAP_OF_SARSCOV2_SIGNALING

TRAF6 FYN IFIT1 ZAP70 NTRK1

1.79e-05218225M42569
PathwayREACTOME_GAP_JUNCTION_TRAFFICKING_AND_REGULATION

GJA4 GJB4 SRC

4.19e-0544223MM14606
PathwayREACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FYN

FYN SRC

4.86e-057222M27912
PathwayPID_PI3KCI_PATHWAY

FYN ZAP70 SRC

5.45e-0548223M141
PathwayREACTOME_GAP_JUNCTION_TRAFFICKING_AND_REGULATION

GJA4 GJB4 SRC

6.54e-0551223M26972
PathwayWP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING

TRAF6 FYN NTRK1 SRC

6.62e-05144224M39691
PathwayPID_CD8_TCR_PATHWAY

TRAF6 FYN ZAP70

7.35e-0553223M88
PathwayREACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING

FYN SRC

8.31e-059222MM15059
PathwayBIOCARTA_TCRA_PATHWAY

FYN ZAP70

8.31e-059222MM1429
PathwayPID_TCR_PATHWAY

TRAF6 FYN ZAP70

1.29e-0464223M34
PathwayREACTOME_PECAM1_INTERACTIONS

FYN SRC

1.52e-0412222MM14835
PathwayREACTOME_PECAM1_INTERACTIONS

FYN SRC

1.52e-0412222M11773
PathwayREACTOME_REGULATION_OF_KIT_SIGNALING

FYN SRC

1.79e-0413222MM14565
PathwayREACTOME_SIGNALING_BY_NTRKS

FYN NTRK1 SRC

2.07e-0475223MM14652
PathwayBIOCARTA_TCRA_PATHWAY

FYN ZAP70

2.09e-0414222M10765
PathwayREACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING

FYN SRC

2.09e-0414222M889
PathwayREACTOME_IRAK1_RECRUITS_IKK_COMPLEX

PELI1 TRAF6

2.09e-0414222M935
PathwayWP_PROLACTIN_SIGNALING

FYN ZAP70 SRC

2.15e-0476223M39601
PathwayREACTOME_NETRIN_1_SIGNALING

FYN SRC

2.41e-0415222MM14965
PathwayREACTOME_IRAK1_RECRUITS_IKK_COMPLEX

PELI1 TRAF6

2.41e-0415222MM15645
PathwayREACTOME_REGULATION_OF_KIT_SIGNALING

FYN SRC

2.75e-0416222M537
PathwayPID_SYNDECAN_3_PATHWAY

FYN SRC

3.12e-0417222M251
PathwayREACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE

FYN SRC

3.50e-0418222MM15023
PathwayREACTOME_EPHRIN_SIGNALING

FYN SRC

3.50e-0418222MM15024
PathwayWP_TCELL_RECEPTOR_SIGNALING

TRAF6 FYN ZAP70

3.55e-0490223M39725
PathwayREACTOME_EPHRIN_SIGNALING

FYN SRC

3.91e-0419222M27310
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

FYN ZAP70

3.91e-0419222M47733
PathwayREACTOME_SIGNALLING_TO_RAS

NTRK1 SRC

4.34e-0420222M12256
PathwayREACTOME_SIGNALING_BY_KIT_IN_DISEASE

FYN SRC

4.34e-0420222M39002
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

FYN SRC

4.80e-0421222M5876
PathwayWP_PATHOGENESIS_OF_SARSCOV2_MEDIATED_BY_NSP9NSP10_COMPLEX

FYN ZAP70

4.80e-0421222M39876
PathwayPID_ECADHERIN_KERATINOCYTE_PATHWAY

FYN SRC

4.80e-0421222M184
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

FYN SRC

4.80e-0421222MM14996
PathwayWP_NRF2ARE_REGULATION

FYN SRC

5.77e-0423222M39761
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

TRAF6 FYN SRC

6.73e-04112223MM15214
PathwayREACTOME_SIGNALING_BY_NTRK2_TRKB

FYN SRC

6.82e-0425222M27864
PathwayREACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK

TRAF6 FYN SRC

6.91e-04113223MM14783
PathwayREACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK

TRAF6 FYN SRC

7.84e-04118223M713
PathwayPID_GLYPICAN_1PATHWAY

FYN SRC

7.97e-0427222M33
PathwayWP_T_CELL_RECEPTOR_AND_COSTIMULATORY_SIGNALING

FYN ZAP70

8.57e-0428222M39632
PathwayREACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE

FYN SRC

9.20e-0429222M27309
PathwayPID_EPHRINB_REV_PATHWAY

FYN SRC

9.85e-0430222M257
PathwayREACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM

PELI1 TRAF6 FYN IFIT1 SRC KPNA1

1.04e-03789226M1060
PathwayREACTOME_SIGNALING_BY_CSF1_M_CSF_IN_MYELOID_CELLS

FYN SRC

1.05e-0331222M46423
PathwayPID_ALPHA_SYNUCLEIN_PATHWAY

FYN SRC

1.12e-0332222M275
PathwayPID_NETRIN_PATHWAY

FYN SRC

1.12e-0332222M108
PathwayREACTOME_GAP_JUNCTION_ASSEMBLY

GJA4 GJB4

1.12e-0332222MM14730
PathwayREACTOME_SIGNALING_BY_NTRKS

FYN NTRK1 SRC

1.13e-03134223M3574
PathwayREACTOME_CD28_CO_STIMULATION

FYN SRC

1.19e-0333222M11725
PathwayREACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS

FYN SRC

1.27e-0334222MM15025
PathwayREACTOME_SIGNALLING_TO_ERKS

NTRK1 SRC

1.27e-0334222M13881
PathwayPID_EPHA_FWDPATHWAY

FYN SRC

1.27e-0334222M177
PathwayREACTOME_CD28_CO_STIMULATION

FYN SRC

1.27e-0334222MM14992
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

TRAF6 FYN SRC

1.29e-03140223M27484
PathwayPID_PI3KCI_AKT_PATHWAY

SRC KPNA1

1.34e-0335222M249
PathwayPID_PI3K_PLC_TRK_PATHWAY

NTRK1 SRC

1.42e-0336222M271
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

FYN SRC

1.50e-0337222MM15022
PathwayREACTOME_SIGNALING_BY_SCF_KIT

FYN SRC

1.50e-0337222MM14564
PathwayREACTOME_GAP_JUNCTION_ASSEMBLY

GJA4 GJB4

1.58e-0338222M14981
PathwayWP_IL1_SIGNALING_PATHWAY

PELI1 TRAF6

1.66e-0339222MM15996
PathwayPID_AMB2_NEUTROPHILS_PATHWAY

FYN SRC

1.84e-0341222M159
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

FYN SRC

1.93e-0342222M27308
PathwayBIOCARTA_TCR_PATHWAY

FYN ZAP70

1.93e-0342222MM1504
PathwayWP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING

TRAF6 SRC

2.02e-0343222M39744
PathwayREACTOME_SIGNALING_BY_SCF_KIT

FYN SRC

2.02e-0343222M508
PathwayWP_IL11_SIGNALING

FYN SRC

2.11e-0344222M39716
PathwayBIOCARTA_TCR_PATHWAY

FYN ZAP70

2.11e-0344222M19784
PathwayREACTOME_NETRIN_1_SIGNALING

FYN SRC

2.11e-0344222M875
PathwayREACTOME_SIGNALING_BY_ERBB2

FYN SRC

2.11e-0344222MM14520
PathwayWP_THYMIC_STROMAL_LYMPHOPOIETIN_TSLP_SIGNALING

FYN SRC

2.41e-0347222M39380
PathwayWP_MICROTUBULE_CYTOSKELETON_REGULATION

NTRK1 SRC

2.51e-0348222M39566
PathwayREACTOME_FCGR_ACTIVATION

FYN SRC

2.51e-0348222MM17214
PathwayPID_AJDISS_2PATHWAY

FYN SRC

2.51e-0348222M142
PathwayWP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING_PATHWAY

TRAF6 SRC

2.51e-0348222MM15897
PathwayWP_IL3_SIGNALING

FYN SRC

2.62e-0349222M39722
PathwayKEGG_ENDOCYTOSIS

TRAF6 NTRK1 SRC

2.68e-03181223M1519
PathwayREACTOME_SIGNALING_BY_ERBB2

FYN SRC

2.72e-0350222M553
PathwayREACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS

FYN SRC

2.83e-0351222M27311
PathwayWP_FOCAL_ADHESION

SRMS FYN SRC

2.94e-03187223MM15913
PathwayWP_NETRINUNC5B_SIGNALING

FYN SRC

2.94e-0352222M39782
PathwayPID_PTP1B_PATHWAY

FYN SRC

2.94e-0352222M50
PathwayWP_INTERFERON_TYPE_I_SIGNALING

FYN ZAP70

3.17e-0354222M39435
PathwayWP_IL1_SIGNALING

PELI1 TRAF6

3.28e-0355222M39346
PathwayWP_RANKLRANK_SIGNALING

TRAF6 SRC

3.28e-0355222M39667
PathwayPID_TXA2PATHWAY

FYN SRC

3.40e-0356222M99
PathwayWP_FOCAL_ADHESION

SRMS FYN SRC

3.50e-03199223M39402
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

FYN NTRK1 ATP6V0A4 SRC

3.65e-03418224MM15587
PathwayWP_KIT_RECEPTOR_SIGNALING

FYN SRC

3.77e-0359222M39350
PathwayPID_FAK_PATHWAY

FYN SRC

3.77e-0359222M281
PathwayWP_MODULATORS_OF_TCR_SIGNALING_AND_T_CELL_ACTIVATION

TRAF6 ZAP70

4.02e-0361222M42548
PathwayWP_TCELL_ANTIGEN_RECEPTOR_TCR_PATHWAY_DURING_STAPHYLOCOCCUS_AUREUS_INFECTION

FYN ZAP70

4.15e-0362222M39429
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

FYN SRC

4.29e-0363222M11187
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

TRAF6 FYN RNF126 ZAP70 SRC

4.34e-03719225MM14540
PathwayREACTOME_EPH_EPHRIN_SIGNALING

FYN SRC

4.56e-0365222MM14911
PathwayWP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY

FYN SRC

4.69e-0366222MM15925
PathwayREACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

FYN SRC

4.69e-0366222MM14990
PathwayKEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION

ATP6V0A4 SRC

4.98e-0368222M16848
PathwayPID_P75_NTR_PATHWAY

TRAF6 NTRK1

4.98e-0368222M153
PathwayPID_VEGFR1_2_PATHWAY

FYN SRC

5.12e-0369222M237
Pubmed

Identification of a genomic reservoir for new TRIM genes in primate genomes.

TRIM49 TRIM49B TRIM51G TRIM49C

1.98e-091931422144910
Pubmed

TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.

TRAF6 FYN SRC

6.40e-09531322447928
Pubmed

The protein tyrosine kinase family of the human genome.

SRMS FYN ZAP70 NTRK1 SRC

1.11e-088331511114734
Pubmed

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.

SRMS FYN SRC

7.66e-08103139062339
Pubmed

The SRC-family tyrosine kinase HCK shapes the landscape of SKAP2 interactome.

SRMS FYN SRC

2.32e-071431329568343
Pubmed

Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.

TRIM49 TRIM49B TRIM49C

2.90e-071531319703589
Pubmed

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.

FYN SRC

7.69e-0723128681387
Pubmed

Deficiency of Fyn protein is prerequisite for apoptosis induced by Src family kinase inhibitors in human mesothelioma cells.

FYN SRC

7.69e-07231222354875
Pubmed

A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling.

FYN NTRK1

7.69e-07231216860569
Pubmed

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke.

FYN SRC

7.69e-07231211175854
Pubmed

Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability.

FYN SRC

7.69e-07231215486073
Pubmed

IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex.

TRAF6 SRC

7.69e-07231211994463
Pubmed

c-Src activation through a TrkA and c-Src interaction is essential for cell proliferation and hematological malignancies.

NTRK1 SRC

7.69e-07231224369899
Pubmed

c-Src but not Fyn promotes proper spindle orientation in early prometaphase.

FYN SRC

7.69e-07231222689581
Pubmed

Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling.

TRAF6 NTRK1

2.31e-06331216246731
Pubmed

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation.

FYN SRC

2.31e-06331212089510
Pubmed

H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity.

FYN SRC

2.31e-06331212695509
Pubmed

Src family kinases are required for integrin but not PDGFR signal transduction.

FYN SRC

2.31e-06331210228160
Pubmed

Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner.

FYN SRC

2.31e-0633127517401
Pubmed

Localized activation of Src-family protein kinases in the mouse egg.

FYN SRC

2.31e-06331217449027
Pubmed

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

FYN SRC

2.31e-0633127958873
Pubmed

Expression of Trk A and Src and their interaction with ERβ ligand binding domain show age and sex dependent alteration in mouse brain.

NTRK1 SRC

2.31e-06331222011838
Pubmed

Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein.

FYN SRC

2.31e-06331223497302
Pubmed

Critical roles of Src family tyrosine kinases in excitatory neuronal differentiation of cultured embryonic stem cells.

FYN SRC

2.31e-06331216859680
Pubmed

Differential transformation capacity of Src family kinases during the initiation of prostate cancer.

FYN SRC

2.31e-06331221464326
Pubmed

Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia.

FYN SRC

2.31e-06331212932824
Pubmed

Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events.

FYN SRC

2.31e-06331216400523
Pubmed

Requirement of SRC-family tyrosine kinases in fat accumulation.

FYN SRC

2.31e-06331216262245
Pubmed

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.

FYN SRC

2.31e-06331211353545
Pubmed

Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake.

FYN SRC

2.31e-06331220080640
Pubmed

Entry of Neisseria meningitidis into mammalian cells requires the Src family protein tyrosine kinases.

FYN SRC

2.31e-06331220176789
Pubmed

Tyrosine phosphorylation of the N-methyl-D-aspartate receptor by exogenous and postsynaptic density-associated Src-family kinases.

FYN SRC

2.31e-06331211483655
Pubmed

Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.

FYN SRC

2.31e-06331219690143
Pubmed

Non-receptor tyrosine kinases in mammalian neurogenesis.

FYN SRC

2.31e-0633128983085
Pubmed

TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway.

TRAF6 SRC

2.31e-06331212631284
Pubmed

Regulation of TRPC6 channel activity by tyrosine phosphorylation.

FYN SRC

2.31e-06331214761972
Pubmed

A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation.

FYN SRC

2.31e-06331215297464
Pubmed

Disease-related modifications in tau affect the interaction between Fyn and Tau.

FYN SRC

2.31e-06331216115884
Pubmed

Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability.

FYN SRC

2.31e-06331210635317
Pubmed

Specific and redundant roles of Src and Fyn in organizing the cytoskeleton.

FYN SRC

2.31e-0633127617039
Pubmed

Differential requirement for Src family tyrosine kinases in the initiation, progression, and metastasis of prostate cancer.

FYN SRC

2.31e-06331225053806
Pubmed

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor.

FYN SRC

2.31e-06331211024032
Pubmed

Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.

FYN SRC KPNA1

4.49e-063631322422068
Pubmed

Amyloid β-abrogated TrkA ubiquitination in PC12 cells analogous to Alzheimer's disease.

TRAF6 NTRK1

4.61e-06431225708205
Pubmed

Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family.

FYN SRC

4.61e-06431210871840
Pubmed

Src Family Kinases Regulate Interferon Regulatory Factor 1 K63 Ubiquitination following Activation by TLR7/8 Vaccine Adjuvant in Human Monocytes and B Cells.

TRAF6 SRC

4.61e-06431229545793
Pubmed

Identification of a consensus site for TRAF6/p62 polyubiquitination.

TRAF6 NTRK1

4.61e-06431218457658
Pubmed

Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402.

FYN ZAP70

4.61e-06431210867021
Pubmed

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.

FYN SRC

4.61e-0643129778343
Pubmed

Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.

FYN SRC

4.61e-0643129118959
Pubmed

Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

FYN SRC

4.61e-06431220100835
Pubmed

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

FYN SRC

4.61e-0643127681396
Pubmed

Activation of FAK and Src are receptor-proximal events required for netrin signaling.

FYN SRC

4.61e-06431215494734
Pubmed

The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains.

FYN SRC

4.61e-06431210458595
Pubmed

Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1.

FYN SRC

4.61e-06431215872086
Pubmed

A unique role for Fyn in CNS myelination.

FYN SRC

4.61e-06431211245687
Pubmed

Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase.

FYN SRC

4.61e-0643127537495
Pubmed

Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl.

FYN SRC

4.61e-06431217094785
Pubmed

Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics.

FYN SRC

4.61e-06431225080486
Pubmed

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

FYN SRC

4.61e-06431216014719
Pubmed

alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases.

FYN SRC

4.61e-06431211078745
Pubmed

T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase.

FYN ZAP70

4.61e-06431211005864
Pubmed

Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain.

FYN SRC

4.61e-06431219258394
Pubmed

FAK-dependent regulation of myofibroblast differentiation.

FYN SRC

4.61e-06431216585062
Pubmed

Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation.

FYN SRC

4.61e-06431225157176
Pubmed

Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells.

FYN SRC

4.61e-0643127521304
Pubmed

Force sensing by mechanical extension of the Src family kinase substrate p130Cas.

FYN SRC

4.61e-06431217129785
Pubmed

State and role of SRC family kinases in replication of herpes simplex virus 1.

FYN SRC

4.61e-06431216537602
Pubmed

Tau interacts with src-family non-receptor tyrosine kinases.

FYN SRC

4.61e-0643129763511
Pubmed

Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation.

FYN SRC

4.61e-06431216882656
Pubmed

Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases.

FYN SRC

4.61e-06431214559149
Pubmed

Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis.

TRAF6 NTRK1

4.61e-06431221541365
Pubmed

Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase.

FYN SRC

4.61e-06431215491611
Pubmed

The Pellino1-PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function.

PELI1 ZAP70

4.61e-06431235058288
Pubmed

Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins.

FYN ZAP70

4.61e-0643127760813
Pubmed

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.

FYN ZAP70

4.61e-0643128551236
Pubmed

Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina.

FYN SRC

4.61e-06431219304944
Pubmed

Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.

TRAF6 FYN ZAP70 SRC

7.48e-0614131420056178
Pubmed

Palatal adhesion is dependent on Src family kinases and p38MAPK.

FYN SRC

7.68e-06531225354453
Pubmed

Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases.

FYN SRC

7.68e-06531212846735
Pubmed

A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors.

FYN SRC

7.68e-06531211149959
Pubmed

The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors.

FYN SRC

7.68e-06531216479011
Pubmed

Calpain II colocalizes with detergent-insoluble rafts on human and Jurkat T-cells.

FYN ZAP70

7.68e-06531212150984
Pubmed

A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes.

FYN SRC

7.68e-06531224399295
Pubmed

Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

FYN SRC

7.68e-06531218194650
Pubmed

Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins.

TRAF6 NTRK1

7.68e-06531218174161
Pubmed

Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.

FYN SRC

7.68e-06531216899217
Pubmed

Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells.

FYN SRC

7.68e-06531222971575
Pubmed

Migration of sympathetic preganglionic neurons in the spinal cord is regulated by Reelin-dependent Dab1 tyrosine phosphorylation and CrkL.

FYN SRC

7.68e-06531217394141
Pubmed

Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes.

FYN SRC

7.68e-0653129195899
Pubmed

Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells.

FYN SRC

7.68e-06531210739664
Pubmed

c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6.

TRAF6 SRC

7.68e-06531237977223
Pubmed

Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.

SRMS SRC

7.68e-06531225897081
Pubmed

TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling.

FYN SRC

7.68e-06531218255094
Pubmed

The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements.

FYN SRC

7.68e-06531217623777
Pubmed

The Tom1L1-clathrin heavy chain complex regulates membrane partitioning of the tyrosine kinase Src required for mitogenic and transforming activities.

FYN SRC

7.68e-06531217785434
Pubmed

Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells.

FYN SRC

7.68e-06531212509223
Pubmed

Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation.

PELI1 TRAF6

7.68e-06531229720226
Pubmed

Vav2 is required for cell spreading.

FYN SRC

7.68e-06531211448999
Pubmed

A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytes.

FYN SRC

7.68e-06531212941616
InteractionIL1R1 interactions

PELI1 TRAF6 SRC

1.56e-0534293int:IL1R1
InteractionCBLB interactions

TRAF6 FYN ZAP70 NTRK1

2.14e-05115294int:CBLB
InteractionSOS1 interactions

FYN ZAP70 NTRK1 SRC

2.29e-05117294int:SOS1
InteractionWASL interactions

FYN NTRK1 ARHGEF10L SRC

2.29e-05117294int:WASL
InteractionSH3BP2 interactions

FYN ZAP70 SRC

4.44e-0548293int:SH3BP2
InteractionSPHK1 interactions

TRAF6 FYN SRC

4.72e-0549293int:SPHK1
InteractionSKAP2 interactions

SRMS FYN SRC

5.33e-0551293int:SKAP2
InteractionPCDHGC3 interactions

FYN NTRK1 SRC

6.32e-0554293int:PCDHGC3
InteractionTXK interactions

FYN NTRK1 SRC

7.44e-0557293int:TXK
InteractionGAB3 interactions

FYN SRC

1.09e-0411292int:GAB3
InteractionPELI1 interactions

PELI1 TRAF6 ZAP70

1.10e-0465293int:PELI1
InteractionPAG1 interactions

FYN ZAP70 SRC

1.21e-0467293int:PAG1
InteractionAIP interactions

PDE7A FYN NTRK1 SRC

1.28e-04182294int:AIP
InteractionPTPRC interactions

FYN ZAP70 SRC

1.32e-0469293int:PTPRC
InteractionSHC3 interactions

ZAP70 NTRK1 SRC

1.49e-0472293int:SHC3
InteractionAICDA interactions

EXOSC1 RNF126 KPNA1

1.56e-0473293int:AICDA
InteractionDIS3 interactions

EXOSC1 RNF126 NTRK1 KPNA1

1.64e-04194294int:DIS3
InteractionCBLC interactions

FYN ZAP70 SRC

1.69e-0475293int:CBLC
InteractionACBD7 interactions

FYN SRC

1.80e-0414292int:ACBD7
InteractionWAS interactions

FYN ZAP70 SRC

2.80e-0489293int:WAS
InteractionSLC25A41 interactions

NUDT19 FYN SRC

2.89e-0490293int:SLC25A41
InteractionRPS6KA3 interactions

TRAF6 FYN NTRK1 SRC

2.93e-04226294int:RPS6KA3
InteractionCOPG1 interactions

FYN RNF126 NTRK1 ARHGEF10L

3.09e-04229294int:COPG1
InteractionZAP70 interactions

PELI1 FYN ZAP70

3.09e-0492293int:ZAP70
InteractionHSPA4 interactions

TRAF6 FYN ZAP70 NTRK1 SRC KPNA1

3.18e-04667296int:HSPA4
InteractionTAMALIN interactions

FYN SRC

3.37e-0419292int:TAMALIN
InteractionSIT1 interactions

FYN ZAP70

3.37e-0419292int:SIT1
InteractionHSP90AB1 interactions

ADGRB3 SRMS TRAF6 FYN IFIT1 NTRK1 SRC

3.38e-04960297int:HSP90AB1
InteractionNR3C1 interactions

NBPF15 INTS3 FYN IFIT1 PHF12 SRC KPNA1

3.69e-04974297int:NR3C1
InteractionUSP7 interactions

TRAF6 FBN1 FYN RNF126 GJB4 NTRK1 SRC KPNA1

3.97e-041313298int:USP7
InteractionSTAT3 interactions

TRAF6 FYN NTRK1 SRC KPNA1

3.97e-04446295int:STAT3
InteractionCD3G interactions

FYN ZAP70

4.13e-0421292int:CD3G
InteractionSYK interactions

EXOSC1 TRAF6 FYN SRC

4.37e-04251294int:SYK
InteractionMAP2 interactions

FYN NTRK1 SRC

4.42e-04104293int:MAP2
InteractionTRPV4 interactions

FYN SRC

4.54e-0422292int:TRPV4
InteractionTRAF6 interactions

PELI1 TRAF6 FYN NTRK1 SRC

4.81e-04465295int:TRAF6
InteractionABL1 interactions

TRAF6 ZAP70 NTRK1 SRC

4.92e-04259294int:ABL1
InteractionZDHHC11 interactions

TRAF6 SRC

4.96e-0423292int:ZDHHC11
Cytoband11p11.12

TRIM49B TRIM51G

3.74e-044231211p11.12
Cytoband1p34.3

ADPRS GJB4

8.14e-04623121p34.3
CytobandEnsembl 112 genes in cytogenetic band chr1p34

GJA4 ADPRS GJB4

1.02e-03294313chr1p34
CytobandEnsembl 112 genes in cytogenetic band chr11p11

TRIM49B TRIM51G

4.82e-03153312chr11p11
CytobandEnsembl 112 genes in cytogenetic band chr11q14

TRIM49 TRIM49C

5.00e-03156312chr11q14
Cytoband19p13.3

RNF126 APC2

1.12e-0223731219p13.3
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM49 TRIM49B TRIM51G TRIM49C

1.14e-059527459
GeneFamilySH2 domain containing

SRMS FYN ZAP70 SRC

1.46e-05101274741
GeneFamilyRing finger proteins

TRIM49 TRAF6 TRIM49B RNF126 TRIM49C

4.82e-0527527558
GeneFamilyGap junction proteins

GJA4 GJB4

4.87e-0422272314
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

APC2 KPNA1

1.87e-0343272409
CoexpressionAtlasalpha beta T cells, T.8Mem.LN, CD8 TCRb CD44high CD122high, Lymph Node, avg-3

PELI1 PDE7A FYN IFIT1 ZAP70

4.36e-05329265GSM538395_500
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI1 FYN IFIT1 ZAP70

5.58e-061693142de213b083f57f47be58427c0ce127fee9f85caa
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

ADGRB3 FBN1 FYN NTRK1

5.58e-061693146373562ab3b1765060212a6a53d6543e7e942e80
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

ADGRB3 FBN1 FYN NTRK1

7.01e-06179314dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI1 PDE7A FYN ZAP70

8.15e-061863144dce1484653bb266e2305cbb306fb11eaf7892e2
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI1 PDE7A FYN ZAP70

8.15e-06186314e23e1246914e230369a716d0d666b98383bf8512
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocye.Tnr.Pdgfa_(Pdgfa)|Striatum / BrainAtlas - Mouse McCarroll V32

SRMS PELI1 FYN

4.31e-059831326250ea4171a0557a67505839cf79d3fe4d9d41a
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr|Striatum / BrainAtlas - Mouse McCarroll V32

SRMS PELI1 FYN

4.31e-059831342875d16ae9fcbaf988cd71be82568f2f862f2dd
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2|Striatum / BrainAtlas - Mouse McCarroll V32

SRMS PELI1 FYN

4.31e-05983137a62a77ca83153dacff4d02d6e32104227d0980d
ToppCellTCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Non-Seminoma-_Embryonal_Carcinoma,_Yolk_Sac_Tumor-1|TCGA-Testes / Sample_Type by Project: Shred V9

SRMS TRIM49 TRIM49C

5.60e-0510731380afce55e410aed65b565d2f432cefa39dae313d
ToppCellTCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Non-Seminoma-_Embryonal_Carcinoma-1|TCGA-Testes / Sample_Type by Project: Shred V9

SRMS TRIM49B TRIM51G

1.09e-04134313d80c9168acbd316761330d29e994e7f9a30ad945
ToppCellTCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Non-Seminoma-_Embryonal_Carcinoma|TCGA-Testes / Sample_Type by Project: Shred V9

SRMS TRIM49 TRIM49B

1.22e-041393136b58d01ce9d9ac23434333f9faf1bb0eef14ba90
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

PELI1 ZNF469 FYN

1.52e-0415031370ac8ae4b1683fb17278a8e4606f2fa0b94988c0
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GJA4 FYN ZAP70

1.68e-04155313c58a5fb8d853f12204e961d633e83452eb12a659
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GJA4 FYN ZAP70

1.68e-041553139cb8c42c2e451b2d4dcd7154a4b1bfd21bbb7ea8
ToppCellCOVID_non-vent-Myeloid-Monocytic-SC_&_Eosinophil|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

GJA4 FBN1 NTRK1

1.78e-041583130d4fe87fc7901dd5f9c004e91708a03cafdb4ad9
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.4|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FYN ZAP70 NTRK1

2.02e-041653134d364e1aae41aea483d1311e5e8ef4fc33e30d5e
ToppCellBasal_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

TRIM49 TRIM49B GJB4

2.05e-0416631323c04d1fba0c1733ccd0e4378fae2edde4fd0a7b
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-DN4|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYN IFIT1 ZAP70

2.09e-0416731310c9fab3573c2948081aac2cec1798e46e59e38a
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

FYN ZAP70 APC2

2.09e-04167313ded4d6cccd3660662f12cf5a512de31d26325f1b
ToppCellsevere-HSPC|World / disease stage, cell group and cell class

FBN1 VWCE NTRK1

2.17e-04169313b0421b73bfdc92f7a2762b4b670b9eae124aa702
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF469 FBN1 NTRK1

2.17e-04169313031465190cd3623a25ef2b868daab8d932c8ff08
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF469 FYN ZAP70

2.24e-04171313187b396059f8802265f54bad2b4882cebb809419
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

PELI1 IFIT1 APC2

2.24e-041713132b7c5a557c4bc5c573211c4d618bdd6766a24916
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF469 FBN1 NTRK1

2.24e-0417131315cb4670ff4234ac46aea8a5911138d6913c4482
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

PELI1 IFIT1 APC2

2.24e-04171313dcb15bc54aeea06ef8f07f1134f3ff1e21ac0e4f
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRMS IFIT1 SRC

2.28e-041723134790323a072cfe76127d704665a42c09601d84be
ToppCellfacs-Lung-Endomucin-24m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 ARHGEF10L SRC

2.32e-04173313a37f38478473290fe35aea8684befc3bf95b161f
ToppCelldroplet-Lung-nan-18m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE7A FYN ZAP70

2.36e-041743133340b44c77f55244e3c2e2ea479d42563f937040
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

2.36e-0417431347e308a777c927ae69ed344cb3dd8561bf2c48a5
ToppCelldroplet-Lung-nan-18m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE7A FYN ZAP70

2.36e-041743135b00a795a9dd1a77305fcac5017cb276afdc1a27
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

2.36e-04174313a92c745d20633909db0f08effa13fc738fda79a6
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRIM49 FYN ZAP70

2.40e-04175313da92eb8af0c7c65fed4a1d960708240f35dd997d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRIM49 FYN ZAP70

2.40e-041753132f43883d7c89f09b0579a390a7431f1f9b832582
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE7A FYN ZAP70

2.48e-04177313d8b1bbc224d062a57a6ad40b4b2af5d6e0fe63b3
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE7A FYN ZAP70

2.48e-041773136d86b2f97426b552dff5ce6ddf0ead1285ed618e
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI1 FYN ZAP70

2.48e-0417731336da06ca9577cdb7c7b5114e604f6546b9765c08
ToppCellfacs-Spleen-nan-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI1 FYN ZAP70

2.48e-04177313ac0cf03e2a1baf84db3ae245d59bbc6ae52c13be
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFIT1 ARHGEF10L SRC

2.48e-0417731326bad614560609d318bfc9c235a698bca4e1c22c
ToppCellwk_20-22-Hematologic_Lymphocytic-NK-Activated_NK|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FYN ZAP70 NTRK1

2.52e-041783135b19dbf9dc8e41e6a16a2abbb798d49ee8d8653f
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-mature_NK_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE7A FYN ZAP70

2.52e-0417831328bb1e3e447261d0cb47e2b6343b17b2d74db525
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE7A FYN ZAP70

2.56e-04179313ac0c257e63a5994282d8b350c1b517cc3fbee52a
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-TRDV2/TRGV9_gdT|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE7A ZAP70 ATP6V0A4

2.56e-04179313f7d3d37505893ae55065c89d957084602729decc
ToppCelldroplet-Spleen-SPLEEN-30m-Lymphocytic-T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI1 FYN ZAP70

2.61e-04180313978728c89497d26287f73974fb738ad9fde61415
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

FYN ZAP70 ATP6V0A4

2.61e-04180313f3d35b2ea78afef37a84232adf5e6e26712b618d
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

FBN1 FYN NTRK1

2.65e-041813132b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCellfacs-Spleen-nan-3m-Lymphocytic-Cd3e_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI1 FYN ZAP70

2.65e-04181313be7c7db6b99603759593e6f79cdcaa4bbf234cb7
ToppCellIPF-Lymphoid-ILC_A|World / Disease state, Lineage and Cell class

PDE7A FYN ZAP70

2.69e-04182313f91bb45baaec76cb3bb26eedbcf0709b2492e93f
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRB3 PELI1 ZNF469

2.74e-04183313dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRB3 PELI1 ZNF469

2.74e-041833134759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCellIPF-Lymphoid-ILC_A|IPF / Disease state, Lineage and Cell class

PDE7A FYN ZAP70

2.74e-0418331349bfeaae13eb236f61a5486ee75c39789936bb8a
ToppCellfacs-Spleen-nan-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI1 FYN ZAP70

2.78e-04184313c37c623c4a5ff1628486d8a6461fa355ad5c264c
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI1 FYN ZAP70

2.78e-041843138c23945bafe8926f25836bc208115edd5214a2b0
ToppCelldroplet-Spleen-SPLEEN-1m-Lymphocytic-T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PELI1 FYN ZAP70

2.82e-0418531339f2b7a35253968f6d744c10ece1478a05cf24da
ToppCellfacs-Marrow-T-cells-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE7A FYN ZAP70

2.82e-04185313e1fd0a807def8c2127194108b1a30c6de7024292
ToppCell3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-NK_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FYN ZAP70 ATP6V0A4

2.87e-04186313885aed2472cead81d60c9f3a28c0ff10eb449592
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

2.87e-041863139d576dce2c5deefef1adda16c6da7055c8d57f8f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

2.87e-04186313bd3bd022b575d9b0ef90d50a5cb874085a827b77
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

2.87e-04186313924cc357b4c4ce8e9b05773bdab544f0b65474cc
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PELI1 GJA4 IFIT1

2.92e-041873136820bfbe552ea5e62cfe699687b051a17d9fda61
ToppCell5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PDE7A FYN ZAP70

2.92e-04187313442b7bf6bc17fc2d38bccd678be8994b0ead374f
ToppCellControl-T_cells|Control / group, cell type (main and fine annotations)

PDE7A FYN ZAP70

2.92e-04187313f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCell5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PDE7A FYN ZAP70

2.92e-04187313c0a18ab7d88420e20e478ccdce6a2cb0a60a7824
ToppCell5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PDE7A FYN ZAP70

2.92e-04187313fda45c15806f34e45d44bb2e1d144591bc6eaa02
ToppCellFetal_29-31_weeks-Immune-natural_killer_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PDE7A FYN ZAP70

2.96e-041883136686dbba990066568aa7573e70a7db8b4758f457
ToppCellCOVID-19-T_cells-CD8+_T_cells|COVID-19 / group, cell type (main and fine annotations)

PDE7A FYN ZAP70

3.01e-041893132c018d6120f65f0b2704b483bc9da1c0984872e3
ToppCellFetal_29-31_weeks-Immune-natural_killer_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PDE7A FYN ZAP70

3.01e-04189313c604da558c9f4055fb36218452463539f2a73223
ToppCellControl-T_cells-CD4+_T_cells|Control / group, cell type (main and fine annotations)

PDE7A FYN ZAP70

3.05e-041903130733be5e54fe15d6d6ea51c154a95258e83f1b92
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-T_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

3.05e-0419031307ea0578ca0561077557203ae660530f53fc4067
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

PELI1 ZAP70 PHF12

3.05e-0419031391ba66d4b56c59523485b17738e93f14bb00afa4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

3.05e-041903135a37568000dfc33fcbb59b578c1963fb7cf872ec
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-T_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

3.05e-041903135b4b3eed7aa798bb7e3c5e968c8dc4144e377a5f
ToppCellFetal_29-31_weeks-Immune-T_lymphocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PDE7A FYN ZAP70

3.05e-041903132a8de1cf27a9ebc3825cf9e7a489ecd064dfc7f9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

3.05e-04190313ba61f04fd38efae01f721ba616252d1372ff1002
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PELI1 IFIT1 SRC

3.05e-04190313e1c02fe6fa43a36381cb9f02569fa9b1c5f5efdc
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PELI1 IFIT1 SRC

3.05e-041903136de15ec88426fbf52acb0a8371f82cf03b6a6237
ToppCellFetal_29-31_weeks-Immune-T_lymphocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PDE7A FYN ZAP70

3.10e-04191313133864ec1e89f97a82c3bb01d2a3c658397fefaf
ToppCellCOVID-19-lung-CD8+_T_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

PDE7A FYN ZAP70

3.10e-04191313543f8ae07cc2e6950c888115a5ca9445e3c0f618
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

3.10e-04191313d9506b88d806aadd4c2b9bf86fe994c47799e7f6
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PDE7A FYN ZAP70

3.10e-04191313c7be771543089fc94e5c62fd22f745189642aec3
ToppCellRV-01._Fibroblast_I|World / Chamber and Cluster_Paper

ADGRB3 FBN1 FYN

3.10e-0419131370c067c54084bfb02c29bab085f4defd477194fb
ToppCellAdult-Immune-T_lymphocyte-D175|Adult / Lineage, Cell type, age group and donor

PDE7A FYN ZAP70

3.10e-041913130b84fd1dc68146d9f72422b102744d2847f5ecb2
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

3.10e-04191313b42c54308abe1241cc38ddce96b9d38d07983891
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

3.10e-0419131396a7179a845d3daa046ed71fa45c51255f130a7f
ToppCellCOVID-19-lung-CD4+_Treg|COVID-19 / Disease (COVID-19 only), tissue and cell type

PDE7A FYN ZAP70

3.10e-041913135a4ad5ae5c2dbfb225158cb598ef649c26a48350
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PELI1 IFIT1 SRC

3.10e-0419131381f77bf497b8e0ae0affe7d5f4f00446547229f6
ToppCellCOVID-19-T_cells-CD4+_T_cells|COVID-19 / group, cell type (main and fine annotations)

PDE7A FYN ZAP70

3.10e-041913130646cca78e24aeb6baa9934d3c439b797c567997
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

3.10e-041913139aabbc65430e2233b8f2d3fff9face7807b88b48
ToppCellCOVID-19-T_cells|COVID-19 / group, cell type (main and fine annotations)

PDE7A FYN ZAP70

3.10e-041913137f64add931b64b8d35836fa6bee9ebab593844d3
ToppCellCOVID-19-lung-CD4+_Treg|lung / Disease (COVID-19 only), tissue and cell type

PDE7A FYN ZAP70

3.10e-0419131373ea3078c1f55cd47e4d99e77b3ce4ff17549d49
ToppCellCOPD-Lymphoid|COPD / Disease state, Lineage and Cell class

PDE7A FYN ZAP70

3.15e-04192313064fefb8212fadab0ff441f4bf643559b7fdb25d
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PDE7A FYN ZAP70

3.15e-04192313dceb8b38c2ddb1a848132bd52edc8e883e7d2aa9
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-Tregs|lymph-node_spleen / Manually curated celltypes from each tissue

PELI1 FYN ZAP70

3.15e-0419231304bd6e135733570e877af9460f87379ed0a5c5f8
ToppCellFetal_29-31_weeks-Immune-T_lymphocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PDE7A FYN ZAP70

3.15e-0419231369a2b04f03a1b82d067018379f7b8a116e954040
ToppCellRV-01._Fibroblast_I|RV / Chamber and Cluster_Paper

ADGRB3 FBN1 FYN

3.15e-04192313356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE7A FYN ZAP70

3.15e-04192313b498618505bb1b7ff9574d06875dd272c11bac39
ToppCellCOPD-Lymphoid-T_Cytotoxic|COPD / Disease state, Lineage and Cell class

PDE7A FYN ZAP70

3.20e-0419331358e94fe2e89cdafc6974938f97a4c162061a437d
ToppCellCOVID-19-lung-CD8+_T_cells|lung / Disease (COVID-19 only), tissue and cell type

PDE7A FYN ZAP70

3.20e-04193313780e23e2705fc5c1b70e37568b79731ced5038bd
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-naive_regulatory_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PELI1 FYN ZAP70

3.20e-0419331328138c35ea82c6b2163f0cae045ca55859347c73
ToppCellLV-01._Fibroblast_I|LV / Chamber and Cluster_Paper

ADGRB3 FBN1 FYN

3.20e-04193313dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCellbackground-NK_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

PDE7A FYN ZAP70

3.20e-04193313f8d6eff1e04926f85d265ec39fe66897fe29574d
DrugPD173952

SRMS FYN SRC

8.37e-0715293CID005328733
DrugPD173956

SRMS FYN SRC

8.37e-0715293CID005330524
Drug6-methoxypurine arabinoside

FYN ZAP70 SRC

3.69e-0624293CID000124757
Drugselva

FYN ZAP70 SRC

5.96e-0628293CID000010157
Drug1-methyl-1H-indole-2-carboxylic acid

FYN SRC

9.38e-064292CID000027695
DrugIN1076

SRMS FYN NTRK1 SRC

1.20e-05112294CID000005309
DrugDasatinib

FYN SRC

7.00e-0510292DB01254
Drugponatinib

FYN NTRK1 SRC

8.81e-0568293ctd:C545373
Drugdasatinib

SRMS FYN SRC

9.60e-0570293CID003062316
Drugtroglitazone; Down 200; 10uM; PC3; HG-U133A

TRAF6 FYN IFIT1 RNF126

1.01e-04193294431_DN
DrugN-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide

FYN ZAP70

1.03e-0412292ctd:C568507
DrugTadjakonine [11087-94-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A

GJA4 FYN ATP6V0A4 SRC

1.05e-041952944424_UP
DrugAC1L1J0H

SRMS FYN ZAP70 SRC

1.09e-04197294CID000004813
DrugAG-028671 [847803-03-6]; Up 200; 10uM; PC3; HT_HG-U133A

FBN1 RNF126 ARHGEF10L SRC

1.11e-041982946582_UP
Diseasecolorectal cancer (implicated_via_orthology)

FYN APC2 SRC

3.40e-0630293DOID:9256 (implicated_via_orthology)
Diseaseintestinal cancer (implicated_via_orthology)

FYN SRC

4.54e-0432292DOID:10155 (implicated_via_orthology)
Diseasekidney disease (implicated_via_orthology)

FYN SRC

7.47e-0441292DOID:557 (implicated_via_orthology)
Diseaseintraocular pressure measurement

ZNF469 FBN1 FYN TRIM51G

1.48e-03509294EFO_0004695
Diseasebasophil measurement

PELI1 ZNF469

1.59e-0360292EFO_0803539
Diseasecarcinoma (implicated_via_orthology)

FYN SRC

1.81e-0364292DOID:305 (implicated_via_orthology)
Diseaseschizophrenia (is_implicated_in)

FYN NTRK1

2.67e-0378292DOID:5419 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
PLAAPVLCMEYIPEL

ARHGEF10L

856

Q9HCE6
RCPAPYEICPEDYLM

ADGRB3

506

O60242
DFMCRIIPNFYPPLE

INTS3

436

Q68E01
LERPRACPPEVYAIM

NTRK1

746

P04629
FFLCCLREPPPVYPD

NUDT19

216

A8MXV4
PEIVFYELERCLLMP

KIAA2026

321

Q5HYC2
MEVCYQLPVLPLDRP

PDE7A

1

Q13946
PELRCIEFPVPKDCY

LRRC14B

416

A6NHZ5
MAPPVRYCIPGERLC

EXOSC1

1

Q9Y3B2
YCPREHMLPCPLAAL

APC2

936

O95996
CPMRNTPEYEELCPR

FBN1

996

P35555
RGYRMPCPQDCPISL

FYN

481

P06241
YDMPRVVACSVEPCP

GJB4

156

Q9NTQ9
IYCFLRCMEPDPEIP

ADPRS

281

Q9NX46
PFRYRMECPEIDCEE

IFIT1

131

P09914
MEPVFVCQRAPCPYL

GJA4

181

P35212
RECPMCRSVGPYVPL

PELI1

331

Q96FA3
DQVERGYRMPCPPEC

SRC

476

P12931
GELICPLCMNYFIDP

TRIM49

11

P0CI25
PPCPRLYGVLMEVEE

NBPF15

586

Q8N660
TMCRDYVLDCNILPP

KPNA1

201

P52294
YCPLLFHMDCLEPPL

PHF12

291

Q96QT6
CSVEIVPRLPDYICP

RNF126

16

Q9BV68
PRPAACPAEVYVLML

SRMS

446

Q9H3Y6
KRMECPPECPPELYA

ZAP70

556

P43403
PPECPPELYALMSDC

ZAP70

561

P43403
GELICPLCMNYFIDP

TRIM49C

11

P0CI26
DPPLESKYECPICLM

TRAF6

61

Q9Y4K3
VECSFMPCPELACPR

VWCE

531

Q96DN2
PAPPPTCYMCVERRF

ZNF469

3111

Q96JG9
VYPCPEPAVERREML

ATP6V0A4

246

Q9HBG4
RELICPICMNYFIDP

TRIM51G

11

A0A3B3IT33
RELICPICMNYFIDP

TRIM49B

11

A6NDI0