Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K9 trimethyltransferase activity

SUV39H2 SETDB1 SUV39H1

4.19e-0651513GO:0140949
GeneOntologyMolecularFunctionhistone H3K9me2 methyltransferase activity

SUV39H2 SETDB1 SUV39H1

4.89e-05101513GO:0140947
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 ERVK-8

6.69e-05111513GO:0004523
GeneOntologyMolecularFunctionmedium-chain fatty acid-CoA ligase activity

ACSF2 ACSM2A ACSM2B

6.69e-05111513GO:0031956
GeneOntologyMolecularFunctionhistone H3K9 methyltransferase activity

SUV39H2 SETDB1 SUV39H1

1.15e-04131513GO:0046974
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 ERVK-8

1.45e-04141513GO:0003964
GeneOntologyMolecularFunctionbenzoate-CoA ligase activity

ACSM2A ACSM2B

1.70e-0431512GO:0018858
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 RPP21 ERVK-7 ERVK-8

1.71e-04371514GO:0016891
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-7 ERVK-8 ERVK-25

1.71e-04371514GO:0004190
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-7 REV3L ERVK-8

1.90e-04381514GO:0034061
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-7 ERVK-8 ERVK-25

1.90e-04381514GO:0070001
GeneOntologyMolecularFunctionanandamide 8,9 epoxidase activity

CYP2D7 CYP2D6

3.37e-0441512GO:0062187
GeneOntologyMolecularFunctionanandamide 11,12 epoxidase activity

CYP2D7 CYP2D6

3.37e-0441512GO:0062188
GeneOntologyMolecularFunctiondecanoate-CoA ligase activity

ACSM2A ACSM2B

3.37e-0441512GO:0102391
GeneOntologyMolecularFunctionsteroid 21-monooxygenase activity

CYP2D7 CYP2D6

3.37e-0441512GO:0004509
GeneOntologyMolecularFunctionprogesterone 21-hydroxylase activity

CYP2D7 CYP2D6

3.37e-0441512GO:0106309
GeneOntologyMolecularFunctionintegrin binding

ADAM20 LAMB1 ITGA9 ITGB8 NISCH DMD TNR

3.77e-041751517GO:0005178
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 RPP21 ERVK-7 ERVK-8

4.01e-04461514GO:0016893
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-8

5.10e-04211513GO:0035613
GeneOntologyMolecularFunctionS-adenosyl-L-methionine binding

SUV39H2 METTL14 METTL17

6.72e-04231513GO:1904047
GeneOntologyMolecularFunctionanandamide 14,15 epoxidase activity

CYP2D7 CYP2D6

8.35e-0461512GO:0062189
GeneOntologyMolecularFunctionanandamide epoxidase activity

CYP2D7 CYP2D6

8.35e-0461512GO:0062186
GeneOntologyMolecularFunctionfatty acid ligase activity

ACSF2 ACSM2A ACSM2B

9.70e-04261513GO:0015645
GeneOntologyMolecularFunctionCoA-ligase activity

ACSF2 ACSM2A ACSM2B

1.09e-03271513GO:0016405
GeneOntologyMolecularFunctionfatty-acyl-CoA synthase activity

ACSM2A ACSM2B

1.54e-0381512GO:0004321
GeneOntologyMolecularFunctionC-X-C chemokine receptor activity

CXCR3 CXCR5

1.54e-0381512GO:0016494
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-6 UBR1 CYP2D7 CYP2D6 MYCBP2 TRIML2 CYP24A1 UBR4 CPZ ERVK-7 SUV39H2 SETDB1 FAM20C TRAF4 SUV39H1 SCAPER FTH1 ERVK-8 DMD

1.62e-03118915119GO:0046914
GeneOntologyMolecularFunctionacid-thiol ligase activity

ACSF2 ACSM2A ACSM2B

1.63e-03311513GO:0016878
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

CPEB2 IPO5 PSD TRIO MYCBP2 ARHGAP9 RASGEF1B NPRL3 RPGR PLXNB1 TNS3

1.67e-0350715111GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

CPEB2 IPO5 PSD TRIO MYCBP2 ARHGAP9 RASGEF1B NPRL3 RPGR PLXNB1 TNS3

1.67e-0350715111GO:0030695
GeneOntologyMolecularFunctionnucleocytoplasmic carrier activity

IPO5 XPO4 XPO7

1.79e-03321513GO:0140142
GeneOntologyMolecularFunctioncell adhesion molecule binding

ADAM20 LAMB1 ITGA9 SLAMF1 ITGB8 NRXN2 NISCH AFDN DMD TNR PLXNB3 PHLDB2

2.03e-0359915112GO:0050839
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 RPP21 ERVK-7 ERVK-8

3.04e-03791514GO:0004521
GeneOntologyBiologicalProcessregulation of cell adhesion

CXCR3 NEXMIF LAMB1 SLAMF1 JAK1 ATXN3L HHLA2 FBLN2 PPP3CA ATXN3 PKHD1 TRPV4 AFDN DMD FUT3 TNR PLXNB1 PLXNB3 PHLDB2 EPHA8

1.46e-0592715120GO:0030155
GeneOntologyBiologicalProcessexploration behavior

CHL1 LRRTM1 ATXN3L ATXN3 TNR

3.20e-05501515GO:0035640
GeneOntologyBiologicalProcessprotein quality control for misfolded or incompletely synthesized proteins

UBR4 FBXL17 ATXN3L ATXN3

3.64e-05261514GO:0006515
GeneOntologyBiologicalProcessprotein localization to cytosolic proteasome complex

ATXN3L ATXN3

5.32e-0521512GO:1904327
DomainDUF4683

NEXMIF REV3L AHDC1

4.68e-0731463PF15735
DomainDUF4683

NEXMIF REV3L AHDC1

4.68e-0731463IPR032757
DomainPre-SET

SUV39H2 SETDB1 SUV39H1

1.60e-0571463PF05033
DomainPreSET

SUV39H2 SETDB1 SUV39H1

1.60e-0571463SM00468
DomainPre-SET_dom

SUV39H2 SETDB1 SUV39H1

1.60e-0571463IPR007728
DomainPRE_SET

SUV39H2 SETDB1 SUV39H1

1.60e-0571463PS50867
DomainIg-like_fold

CHL1 TRIO MYCBP2 AMIGO1 ANTXRL HHLA2 HMCN1 PKHD1 KIR3DL3 KIR2DL1 KIR2DL2 CAMTA1 TNR USH2A PLXNB1 PLXNB3 EPHA8

3.81e-0570614617IPR013783
DomainAtaxin-3

ATXN3L ATXN3

6.07e-0521462IPR033865
DomainHistone_H3-K9_MeTrfase

SUV39H2 SUV39H1

6.07e-0521462IPR011381
DomainSAM_MT43_SUVAR39_3

SUV39H2 SUV39H1

6.07e-0521462PS51579
Domain-

CHL1 TRIO MYCBP2 AMIGO1 ANTXRL HHLA2 HMCN1 PKHD1 KIR2DL1 KIR2DL2 CAMTA1 TNR USH2A PLXNB1 PLXNB3 EPHA8

6.36e-05663146162.60.40.10
DomainTIG

PKHD1 CAMTA1 PLXNB1 PLXNB3

9.57e-05311464PF01833
DomainIPT

PKHD1 CAMTA1 PLXNB1 PLXNB3

1.09e-04321464IPR002909
DomainCAF1C_H4-bd

RBBP4 RBBP7

1.81e-0431462PF12265
DomainHistone-bd_RBBP4_N

RBBP4 RBBP7

1.81e-0431462IPR022052
DomainEGF_1

ADAM20 LAMB1 ITGB8 FBLN2 HMCN1 NRXN2 TNR USH2A GP2

1.82e-042551469PS00022
DomainEGF-like_CS

ADAM20 LAMB1 ITGB8 FBLN2 HMCN1 NRXN2 TNR GP2 EPHA8

2.17e-042611469IPR013032
DomainEGF_2

ADAM20 LAMB1 ITGB8 FBLN2 HMCN1 NRXN2 TNR GP2 EPHA8

2.42e-042651469PS01186
DomainPost-SET_dom

SUV39H2 SETDB1 SUV39H1

2.43e-04161463IPR003616
DomainPostSET

SUV39H2 SETDB1 SUV39H1

2.43e-04161463SM00508
DomainPOST_SET

SUV39H2 SETDB1 SUV39H1

2.43e-04161463PS50868
DomainAMP-bd_C

ACSF2 ACSM2A ACSM2B

2.94e-04171463IPR025110
DomainAMP-binding_C

ACSF2 ACSM2A ACSM2B

2.94e-04171463PF13193
Domain-

RBBP4 RBBP7 APAF1 EML5 WDR75 NBEAL2 CSTF1 IFT122 PLXNB1 PLXNB3

2.95e-04333146102.130.10.10
DomainWD40/YVTN_repeat-like_dom

RBBP4 RBBP7 APAF1 EML5 WDR75 NBEAL2 CSTF1 IFT122 PLXNB1 PLXNB3

3.09e-0433514610IPR015943
DomainJosephin

ATXN3L ATXN3

3.60e-0441462SM01246
DomainJOSEPHIN

ATXN3L ATXN3

3.60e-0441462PS50957
DomainJosephin

ATXN3L ATXN3

3.60e-0441462IPR006155
DomainJosephin

ATXN3L ATXN3

3.60e-0441462PF02099
DomainWD40_repeat_dom

RBBP4 RBBP7 UBR4 APAF1 EML5 WDR75 NBEAL2 CSTF1 IFT122

5.56e-042971469IPR017986
DomainWD40

RBBP4 RBBP7 APAF1 EML5 WDR75 NBEAL2 CSTF1 IFT122

9.98e-042591468PF00400
DomainAMP-binding_CS

ACSF2 ACSM2A ACSM2B

1.07e-03261463IPR020845
DomainVWF_A

VWA8 ITGB8 ANTXRL HMCN1 ANAPC1

1.08e-03991465IPR002035
DomainIPT

PKHD1 PLXNB1 PLXNB3

1.19e-03271463SM00429
DomainWD40

RBBP4 RBBP7 APAF1 EML5 WDR75 NBEAL2 CSTF1 IFT122

1.24e-032681468SM00320
DomainZnF_UBR1

UBR1 UBR4

1.24e-0371462SM00396
DomainZF_UBR

UBR1 UBR4

1.24e-0371462PS51157
Domainzf-UBR

UBR1 UBR4

1.24e-0371462PF02207
DomainZnf_UBR

UBR1 UBR4

1.24e-0371462IPR003126
DomainAMP_BINDING

ACSF2 ACSM2A ACSM2B

1.33e-03281463PS00455
DomainIg_E-set

MYCBP2 PKHD1 CAMTA1 PLXNB1 PLXNB3

1.35e-031041465IPR014756
DomainWD40_repeat

RBBP4 RBBP7 APAF1 EML5 WDR75 NBEAL2 CSTF1 IFT122

1.36e-032721468IPR001680
DomainWD_REPEATS_1

RBBP4 RBBP7 APAF1 EML5 WDR75 NBEAL2 CSTF1 IFT122

1.57e-032781468PS00678
DomainWD_REPEATS_2

RBBP4 RBBP7 APAF1 EML5 WDR75 NBEAL2 CSTF1 IFT122

1.60e-032791468PS50082
DomainWD_REPEATS_REGION

RBBP4 RBBP7 APAF1 EML5 WDR75 NBEAL2 CSTF1 IFT122

1.60e-032791468PS50294
DomainAMP-binding

ACSF2 ACSM2A ACSM2B

1.63e-03301463PF00501
DomainAMP-dep_Synth/Lig

ACSF2 ACSM2A ACSM2B

1.63e-03301463IPR000873
DomainPlexin_cytopl

PLXNB1 PLXNB3

2.11e-0391462PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNB1 PLXNB3

2.11e-0391462IPR013548
DomainPlexin

PLXNB1 PLXNB3

2.11e-0391462IPR031148
DomainEGF-like_dom

ADAM20 LAMB1 FBLN2 HMCN1 NRXN2 TNR GP2

3.48e-032491467IPR000742
Domainig

CHL1 AMIGO1 HMCN1 KIR3DL3 KIR2DL1 KIR2DL2

3.83e-031901466PF00047
DomainImmunoglobulin

CHL1 AMIGO1 HMCN1 KIR3DL3 KIR2DL1 KIR2DL2

3.83e-031901466IPR013151
DomainVWFA

VWA8 ITGB8 ANTXRL HMCN1

3.91e-03821464PS50234
DomainSET

SUV39H2 SETDB1 SUV39H1

4.01e-03411463PF00856
DomainVWA

VWA8 ITGB8 ANTXRL HMCN1

4.26e-03841464SM00327
DomainKelch_2

LZTR1 KLHDC3

4.47e-03131462IPR011498
DomainKelch_2

LZTR1 KLHDC3

4.47e-03131462PF07646
DomainPSI

ITGB8 PLXNB1 PLXNB3

4.90e-03441463IPR016201
DomainDynein_heavy_chain_D4_dom

DNAH14 DYNC1H1

5.19e-03141462IPR024317
DomainDynein_HC_stalk

DNAH14 DYNC1H1

5.19e-03141462IPR024743
DomainIMPORTIN_B_NT

IPO5 XPO7

5.19e-03141462PS50166
DomainATPase_dyneun-rel_AAA

VWA8 DYNC1H1

5.19e-03141462IPR011704
DomainSEA

MUC16 TMPRSS11D

5.19e-03141462SM00200
DomainMT

DNAH14 DYNC1H1

5.19e-03141462PF12777
DomainAAA_8

DNAH14 DYNC1H1

5.19e-03141462PF12780
DomainAAA_5

VWA8 DYNC1H1

5.19e-03141462PF07728
DomainSET

SUV39H2 SETDB1 SUV39H1

5.56e-03461463SM00317
DomainPSI

ITGB8 PLXNB1 PLXNB3

5.56e-03461463SM00423
DomainDHC_fam

DNAH14 DYNC1H1

5.96e-03151462IPR026983
Domain-

MUC16 TMPRSS11D

5.96e-031514623.30.70.960
DomainDynein_heavy

DNAH14 DYNC1H1

5.96e-03151462PF03028
DomainDynein_heavy_dom

DNAH14 DYNC1H1

5.96e-03151462IPR004273
DomainGalactose-bd-like

MYCBP2 LAMB1 NPRL3 EPHA8

6.34e-03941464IPR008979
DomainPH_dom-like

PSD TRIO ARHGAP9 JAK1 CADPS NBEAL2 PID1 PHLDB2 TNS3

6.38e-034261469IPR011993
DomainLaminin_N

LAMB1 USH2A

6.78e-03161462IPR008211
DomainLamNT

LAMB1 USH2A

6.78e-03161462SM00136
DomainLAMININ_NTER

LAMB1 USH2A

6.78e-03161462PS51117
DomainLaminin_N

LAMB1 USH2A

6.78e-03161462PF00055
DomainSET_dom

SUV39H2 SETDB1 SUV39H1

7.01e-03501463IPR001214
DomainSET

SUV39H2 SETDB1 SUV39H1

7.01e-03501463PS50280
DomainWW_DOMAIN_1

NEDD4L ARHGAP9 DMD

7.41e-03511463PS01159
DomainWW_DOMAIN_2

NEDD4L ARHGAP9 DMD

7.41e-03511463PS50020
DomainImportin-beta_N

IPO5 XPO7

7.64e-03171462IPR001494
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

RBBP4 RBBP7 SUV39H2 SETDB1 SUV39H1

3.19e-05461135MM14933
Pubmed

H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification.

SUV39H2 SETDB1 SUV39H1

8.51e-083154330606806
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

VWA8 TOPBP1 SETDB1 NRXN2 CADPS SCAPER CEP152 PLXNB3

1.27e-07130154812421765
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

LZTR1 PSD VWA8 RBBP4 RBBP7 RBL1 LAMB1 REV3L TRRAP ADCY6 JAK1 SETDB1 EML5 ANAPC1 CADPS SCAPER TCF25 CSMD1 PHLDB2

5.67e-0711161541931753913
Pubmed

Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases.

RBBP4 RBBP7 SUV39H1

1.69e-066154311788710
Pubmed

Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

NEDD4L APAF1 TOGARAM1 ADCY6 PLXNB1

3.50e-065215459455477
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

IPO5 TRIO MYCBP2 PLA2G3 UBR4 LAMB1 REV3L GNPTG ITGB8 JAK1 SETDB1 PPP3CA CADPS NISCH AFDN IFT122 ABHD12 DYNC1H1 PLXNB3

4.46e-0612851541935914814
Pubmed

A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia.

KIR3DL3 KIR2DL1 KIR2DL2

4.69e-068154315730517
Pubmed

Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development.

SUV39H2 SETDB1 SUV39H1

9.99e-0610154323333759
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NEDD4L ADCY6 SETDB1 CADPS NISCH TCF25 CAMTA1 DYNC1H1 PLXNB3 XPO7

1.48e-054071541012693553
Pubmed

Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia.

SUV39H2 SETDB1 SUV39H1

1.82e-0512154321402781
Pubmed

Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains.

SUV39H2 SUV39H1

1.95e-052154214690610
Pubmed

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.

SUV39H2 SUV39H1

1.95e-052154214690609
Pubmed

The genomic structure and expression of MJD, the Machado-Joseph disease gene.

ATXN3L ATXN3

1.95e-052154211450850
Pubmed

Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.

ATXN3L ATXN3

1.95e-052154217488727
Pubmed

Regional and age-dependent changes in ubiquitination in cellular and mouse models of spinocerebellar ataxia type 3.

ATXN3L ATXN3

1.95e-052154237122622
Pubmed

KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target.

HHLA2 KIR3DL3

1.95e-052154234244312
Pubmed

Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells.

ATXN3L ATXN3

1.95e-052154223955261
Pubmed

Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.

CYP2D7 CYP2D6

1.95e-052154225808902
Pubmed

Cell-type differential targeting of SETDB1 prevents aberrant CTCF binding, chromatin looping, and cis-regulatory interactions.

CYP24A1 SETDB1

1.95e-052154238167730
Pubmed

Vulnerability of frontal brain neurons for the toxicity of expanded ataxin-3.

ATXN3L ATXN3

1.95e-052154230576445
Pubmed

Stimulation of calcineurin Aalpha activity attenuates muscle pathophysiology in mdx dystrophic mice.

PPP3CA DMD

1.95e-052154218199592
Pubmed

Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?

CYP2D7 CYP2D6

1.95e-052154211207030
Pubmed

Role of histone lysine methyltransferases SUV39H1 and SETDB1 in gliomagenesis: modulation of cell proliferation, migration, and colony formation.

SETDB1 SUV39H1

1.95e-052154223943221
Pubmed

A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.

ATXN3L ATXN3

1.95e-052154217632007
Pubmed

Basal and stress-induced Hsp70 are modulated by ataxin-3.

ATXN3L ATXN3

1.95e-052154222777893
Pubmed

Characterization of the gene encoding mouse retinoblastoma binding protein-7, a component of chromatin-remodeling complexes.

RBBP4 RBBP7

1.95e-052154212376095
Pubmed

Systemic Jak1 activation provokes hepatic inflammation and imbalanced FGF23 production and cleavage.

JAK1 FGF23

1.95e-052154233475190
Pubmed

PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.

ATXN3L ATXN3

1.95e-052154218668148
Pubmed

Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model.

ATXN3L ATXN3

1.95e-052154234220448
Pubmed

A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.

ATXN3L ATXN3

1.95e-052154225301414
Pubmed

Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.

ATXN3L ATXN3

1.95e-052154219666135
Pubmed

Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.

ACSM2A ACSM2B

1.95e-052154219634011
Pubmed

Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice.

PPP3CA DMD

1.95e-052154216793906
Pubmed

Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death.

ATXN3L ATXN3

1.95e-052154220637808
Pubmed

A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes.

ATXN3L ATXN3

1.95e-052154234716557
Pubmed

Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review).

RBBP4 RBBP7

1.95e-052154238577935
Pubmed

Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.

ATXN3L ATXN3

1.95e-052154223626768
Pubmed

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.

SUV39H2 SUV39H1

1.95e-052154214702045
Pubmed

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.

SUV39H2 SUV39H1

1.95e-052154211701123
Pubmed

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.

CYP2D7 CYP2D6

1.95e-05215423123997
Pubmed

Suv39h-catalyzed H3K9me3 is critical for euchromatic genome organization and the maintenance of gene transcription.

SUV39H2 SUV39H1

1.95e-052154238719473
Pubmed

Extreme disruption of heterochromatin is required for accelerated hematopoietic aging.

SUV39H2 SUV39H1

1.95e-052154232305044
Pubmed

The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina.

ATXN3L ATXN3

1.95e-052154233176149
Pubmed

Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture.

ATXN3L ATXN3

1.95e-052154236010688
Pubmed

Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology.

ATXN3L ATXN3

1.95e-052154223242710
Pubmed

Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.

ATXN3L ATXN3

1.95e-052154223349684
Pubmed

Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.

ATXN3L ATXN3

1.95e-052154218502140
Pubmed

Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification.

FGF23 FAM20C

1.95e-052154223325605
Pubmed

Neurodegenerative phosphoprotein signaling landscape in models of SCA3.

ATXN3L ATXN3

1.95e-052154233741019
Pubmed

N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation.

ATXN3L ATXN3

1.95e-052154221653538
Pubmed

The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.

ACSM2A ACSM2B

1.95e-052154216521160
Pubmed

Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.

CYP2D7 CYP2D6

1.95e-052154211032406
Pubmed

Temperature-dependent, irreversible formation of amyloid fibrils by a soluble human ataxin-3 carrying a moderately expanded polyglutamine stretch (Q36).

ATXN3L ATXN3

1.95e-052154214661975
Pubmed

YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.

ATXN3L ATXN3

1.95e-052154211978767
Pubmed

Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties.

ATXN3L ATXN3

1.95e-052154221060878
Pubmed

Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.

ATXN3L ATXN3

1.95e-052154217764659
Pubmed

The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models.

ATXN3L ATXN3

1.95e-052154228676741
Pubmed

Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways.

ATXN3L ATXN3

1.95e-052154230231063
Pubmed

Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts.

CXCR3 CXCR5

1.95e-052154214618028
Pubmed

Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.

ATXN3L ATXN3

1.95e-052154212914917
Pubmed

Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.

ATXN3L ATXN3

1.95e-052154220064935
Pubmed

Aberrant levels of SUV39H1 and SUV39H2 methyltransferase are associated with genomic instability in chronic lymphocytic leukemia.

SUV39H2 SUV39H1

1.95e-052154228833505
Pubmed

Mitochondrial Morphology, Function and Homeostasis Are Impaired by Expression of an N-terminal Calpain Cleavage Fragment of Ataxin-3.

ATXN3L ATXN3

1.95e-052154230364204
Pubmed

The Histone Methyltransferase SETDB1 Controls T Helper Cell Lineage Integrity by Repressing Endogenous Retroviruses.

SETDB1 SUV39H1

1.95e-052154230737147
Pubmed

Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.

ATXN3L ATXN3

1.95e-052154217626202
Pubmed

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.

ATXN3L ATXN3

1.95e-052154222843411
Pubmed

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation.

SUV39H2 SUV39H1

1.95e-052154228760199
Pubmed

A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells.

SUV39H2 SUV39H1

1.95e-052154214765126
Pubmed

Disease-associated oligodendrocyte signatures are spatiotemporally dysregulated in spinocerebellar ataxia type 3.

ATXN3L ATXN3

1.95e-052154236875652
Pubmed

The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease.

ATXN3L ATXN3

1.95e-052154224683430
Pubmed

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo.

ATXN3L ATXN3

1.95e-05215428640226
Pubmed

The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin.

SUV39H2 SUV39H1

1.95e-052154227426629
Pubmed

Expanded ATXN3 frameshifting events are toxic in Drosophila and mammalian neuron models.

ATXN3L ATXN3

1.95e-052154222337953
Pubmed

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis.

FGF23 FAM20C

1.95e-052154224706917
Pubmed

KIR Polymorphism Modulates the Size of the Adaptive NK Cell Pool in Human Cytomegalovirus-Infected Individuals.

KIR2DL1 KIR2DL2

1.95e-052154231519864
Pubmed

Polyglutamine-induced neurodegeneration in SCA3 is not mitigated by non-expanded ataxin-3: conclusions from double-transgenic mouse models.

ATXN3L ATXN3

1.95e-052154220079840
Pubmed

Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.

ACSM2A ACSM2B

1.95e-052154229948332
Pubmed

METTL14 decreases FTH1 mRNA stability via m6A methylation to promote sorafenib-induced ferroptosis of cervical cancer.

METTL14 FTH1

1.95e-052154238738555
Pubmed

The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.

CYP2D7 CYP2D6

1.95e-052154219594327
Pubmed

Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.

CYP2D7 CYP2D6

1.95e-052154226297049
Pubmed

Overlapping functions of RBBP4 and RBBP7 in regulating cell proliferation and histone H3.3 deposition during mouse preimplantation development.

RBBP4 RBBP7

1.95e-052154234709113
Pubmed

A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.

ATXN3L ATXN3

1.95e-052154225320121
Pubmed

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization.

SUV39H2 SUV39H1

1.95e-052154223451023
Pubmed

Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

SUV39H2 SUV39H1

1.95e-052154224981170
Pubmed

Study of subcellular localization and proteolysis of ataxin-3.

ATXN3L ATXN3

1.95e-052154218353661
Pubmed

A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.

CYP2D7 CYP2D6

1.95e-052154215051713
Pubmed

Ataxin-3 is subject to autolytic cleavage.

ATXN3L ATXN3

1.95e-052154216939621
Pubmed

Impaired Oligodendrocyte Maturation Is an Early Feature in SCA3 Disease Pathogenesis.

ATXN3L ATXN3

1.95e-052154235042771
Pubmed

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

RBBP4 NEXMIF REV3L AHDC1 SUV39H1

2.01e-0574154529795351
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CPEB2 IPO5 NEDD4L TRIO RBBP7 LRRC49 LRRTM1 CDKL5 PPP3CA NRXN2 CADPS NISCH SCAPER FTH1 AFDN DMD TNR ABHD12 DYNC1H1

2.02e-0514311541937142655
Pubmed

Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.

KIR3DL3 KIR2DL1 KIR2DL2

2.99e-0514154319875891
Pubmed

[Genotype and haplotype analysis of killer cell immunoglobulin-like receptors in ankylosing spondylitis].

KIR3DL3 KIR2DL1 KIR2DL2

2.99e-0514154319489269
Pubmed

Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population.

KIR3DL3 KIR2DL1 KIR2DL2

2.99e-0514154315896204
Pubmed

Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.

KIR3DL3 KIR2DL1 KIR2DL2

2.99e-0514154318945962
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

LZTR1 TRIO MYCBP2 VWA8 UBR4 REV3L TRRAP AHDC1 ITPR3 FAM20C TRAF4 NBEAL2 NISCH NPRL3 ZFYVE26 DYNC1H1

3.42e-0511051541635748872
Pubmed

Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.

RBBP4 RBBP7 SUV39H2 AHDC1 SUV39H1

3.51e-0583154520562864
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

IPO5 MYCBP2 RBBP4 RBBP7 UBR4 TRRAP ITPR3 WDR75 ANAPC1 AFDN DYNC1H1 XPO7

3.69e-056531541222586326
Pubmed

Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.

SUV39H2 SETDB1 SUV39H1

3.73e-0515154335907431
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil.

KIR3DL3 KIR2DL1 KIR2DL2

3.73e-0515154320082646
Pubmed

[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].

KIR3DL3 KIR2DL1 KIR2DL2

3.73e-0515154320356536
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR3DL3 KIR2DL1 KIR2DL2

1.72e-04181113620
GeneFamilyWD repeat domain containing

RBBP4 RBBP7 APAF1 EML5 WDR75 NBEAL2 CSTF1 IFT122

2.13e-042621118362
GeneFamilyAtaxins|MJD deubiquinating enzymes

ATXN3L ATXN3

2.22e-0441112997
GeneFamilyAcyl-CoA synthetase family

ACSF2 ACSM2A ACSM2B

5.28e-0426111340
GeneFamilyCD molecules|C-X-C motif chemokine receptors

CXCR3 CXCR5

5.51e-04611121094
GeneFamilyLysine methyltransferases|Myb/SANT domain containing|Polycomb repressive complex 2

RBBP4 RBBP7

5.51e-04611121347
GeneFamilyOlfactory receptors, family 3

OR3A2 OR3A3

5.51e-0461112150
GeneFamilyExportins

XPO4 XPO7

7.69e-0471112547
GeneFamilyUbiquitin protein ligase E3 component n-recognins

UBR1 UBR4

7.69e-0471112785
GeneFamilyFibulins

FBLN2 HMCN1

1.02e-0381112556
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SUV39H2 SETDB1 SUV39H1

1.17e-03341113487
GeneFamilyHistone deacetylases, class I|EMSY complex|NuRD complex|SIN3 histone deacetylase complex

RBBP4 RBBP7

1.31e-03911121306
GeneFamilyPlexins

PLXNB1 PLXNB3

1.31e-0391112683
GeneFamilyHistone deacetylases, class I|EMSY complex|NuRD complex|SIN3 histone deacetylase complex

RBBP4 RBBP7

2.37e-031211121243
GeneFamilyPHD finger proteins|NuRD complex

RBBP4 RBBP7

2.37e-031211121305
GeneFamilyADAM metallopeptidase domain containing|CD molecules

CXCR3 TNFRSF17 SLAMF1 CXCR5 KIR3DL3 KIR2DL1 KIR2DL2 FUT3

2.97e-033941118471
CoexpressionGSE27786_NKTCELL_VS_ERYTHROBLAST_UP

CPEB2 ZFP90 NEDD4L RNF44 TOGARAM1 COG3 TCF25 ABHD12

1.91e-051991498M4865
CoexpressionGSE12003_MIR223_KO_VS_WT_BM_PROGENITOR_4D_CULTURE_UP

LZTR1 TRIO MYCBP2 UBR4 TRRAP ADCY6 JAK1 CLTA

1.98e-052001498M387
CoexpressionGSE2770_UNTREATED_VS_IL4_TREATED_ACT_CD4_TCELL_6H_DN

IPO5 REV3L METTL14 KLHDC3 NBEAL2 MTBP RPGR INVS

1.98e-052001498M6021
CoexpressionAtlasDevelopingKidney_e15.5_Medullary collecting duct_emap-28063_top-relative-expression-ranked_1000

NEDD4L MYCBP2 VWA8 LAMB1 REV3L ITPR3 SLC38A2 FAM20C NBEAL2 SCAPER PKHD1 SECISBP2 TRPV4 PARPBP ACSM2A ABHD12 PLXNB1

1.71e-0578614017gudmap_developingKidney_e15.5_Medullary collecting duct_1000
CoexpressionAtlasDevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#5_top-relative-expression-ranked_1000

TRIO MYCBP2 VWA8 RBBP4 REV3L PER3 ANAPC1 PARPBP ABHD12

1.96e-052261409gudmap_developingKidney_e15.5_stage III -IV renal corpusc_1000_k5
ToppCellIIH-CD8-CD4_Treg|IIH / Condition, Cell_class and T cell subcluster

TOPBP1 LAMB1 C1orf74 ITGB8 AMIGO1 CEP152 IFT122 RPGR PARPBP

1.04e-081801499d1a8b25115c80e5a5bd0b8244167a98250ab9778
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4L LAMB1 ACSF2 ITGB8 DNAH14 PKHD1 AFDN ACSM2A ACSM2B

1.98e-0819414997002937e8903e037332a215d00fbc7c7843b33f2
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|356C / Donor, Lineage, Cell class and subclass (all cells)

LZTR1 PLA2G3 FBXL17 ADCY6 ITGB8 AMIGO1 EML5 PIERCE1

6.65e-08159149824f87c666eff10c1844c900ffd7ad49fa9f80481
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

ACSF2 FAM20C RASGEF1B TRPV4 CSMD1 ACSM2A USH2A GP2

1.80e-071811498c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 LRRTM1 TRAF4 NRXN2 KCNMB4 CSMD1 TNR PID1

2.05e-071841498278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 LRRTM1 TRAF4 NRXN2 KCNMB4 CSMD1 TNR PID1

2.05e-0718414988d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LZTR1 PLA2G3 FBXL17 ADCY6 AMIGO1 EML5 PIERCE1

1.48e-06166149789e2b8453180983533faccb4275867861876d7ee
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CYP24A1 ACSF2 TRPV4 FUT3 CSMD1 ACSM2A ACSM2B

2.19e-0617614971595dbeee336a81e581325d63208ec6262664ee9
ToppCellP28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CHL1 LAMB1 LRRTM1 HELQ ITGB8 CSMD1 PLXNB3

2.54e-0618014971e819c5c87704ec6535dfeaae56561895e239d07
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 CYP24A1 LAMB1 DNAH14 PKHD1 PID1 TNS3

3.15e-061861497f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 CYP24A1 LAMB1 DNAH14 PKHD1 PID1 TNS3

3.38e-061881497af740fa78542438fdff627ea1f74f4eee43316be
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 LRRTM1 ITGA9 TRAF4 CSMD1 TNR PID1

3.63e-0619014979b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 LRRTM1 ITGA9 TRAF4 CSMD1 TNR PID1

3.63e-061901497d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 TRIO LAMB1 ITGB8 DNAH14 PKHD1 TNS3

3.75e-061911497d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4L LAMB1 DNAH14 PKHD1 TRPV4 ACSM2A ACSM2B

4.02e-06193149782e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 REV3L CADPS NISCH SCAPER DYNC1H1 PHLDB2

4.30e-0619514973e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 REV3L CADPS NISCH SCAPER DYNC1H1 PHLDB2

4.30e-0619514977796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPP21 LAMB1 CDKL5 CSTF1 DMD CAMTA1

1.60e-05159149608a1cd71eac4322fb313324f74fe8e37998f2d7d
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RPP21 LAMB1 CDKL5 CSTF1 DMD CAMTA1

1.60e-0515914969bdfa7f5aa7753fe25b787bd43d694b6093d77eb
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

LZTR1 PLA2G3 ADCY6 AMIGO1 EML5 PIERCE1

1.78e-0516214962259e9536147e9cdee772e3a30ba7d104573262c
ToppCellLA-16._Neuronal|World / Chamber and Cluster_Paper

CHL1 ITGB8 FTH1 KCNMB4 RPGR PLXNB3

2.19e-0516814962fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCellLA-16._Neuronal|LA / Chamber and Cluster_Paper

CHL1 ITGB8 FTH1 KCNMB4 RPGR PLXNB3

2.19e-051681496c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRIML2 C1orf74 HMCN1 KCNMB4 RPGR CSMD1

2.42e-0517114961597459c971d6befa991d59dc66b41b6a522f797
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ACSF2 HHLA2 FAM20C TRPV4 ACSM2A ACSM2B

2.58e-0517314968888434641ea554a9b62c436e87920378eef29cd
ToppCell5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHL1 LAMB1 LRRTM1 ITGB8 DMD PLXNB3

2.67e-051741496c9d4e375dedd2b099a9ed70ec38ff35bbb0ce48a
ToppCell5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHL1 LAMB1 LRRTM1 ITGB8 DMD PLXNB3

2.67e-0517414961463c98f8f519dd030587abbdbeb1b4e1bca5dd1
ToppCell5'-GW_trimst-2-LymphNode-Neuronal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHL1 LAMB1 LRRTM1 ITGB8 DMD PLXNB3

2.67e-051741496d421c0069d24cb560a3a429929e3cd1eceaeabcf
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRRC49 TTC9C AMIGO1 FBLN2 MTBP PARPBP

2.67e-0517414966c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLA2G3 MUC16 CPZ FBLN2 NRXN2 NXPH4

2.67e-0517414964da79da7a09ee1e345102c5331675ebcdbe56171
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ACSF2 PKHD1 FUT3 CSMD1 ACSM2A ACSM2B

2.94e-0517714962f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCelldroplet-Bladder-nan-24m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 FGF23 FBLN2 NRXN2 KCNMB4 CSMD1

3.13e-051791496dfd9d29281510d32f1a2e8336d2e58ef496cfd1d
ToppCell5'-Adult-SmallIntestine-Neuronal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHL1 LRRTM1 ITGB8 HMCN1 KCNMB4 PLXNB3

3.22e-0518014965e6e38ee0758ef2342a6a821c78ed24b57bb7b11
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRTM1 TRAF4 NRXN2 KCNMB4 CSMD1 PID1

3.22e-051801496fa819df81fca95c2cc602fede635cb03e3f35fad
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRTM1 TRAF4 NRXN2 KCNMB4 CSMD1 PID1

3.22e-051801496907cd510fd2e21532ce04ba687e8894f7af71f27
ToppCell5'-Adult-SmallIntestine-Neuronal-Glial_mature-Adult_Glia|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHL1 LRRTM1 ITGB8 HMCN1 KCNMB4 PLXNB3

3.22e-051801496b88cd7ae922782176c057342d1b9eb9b8e5e7204
ToppCell5'-Adult-SmallIntestine-Neuronal-Glial_mature|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHL1 LRRTM1 ITGB8 HMCN1 KCNMB4 PLXNB3

3.22e-051801496ebd6e719a03f25155fa8181be19469d04d6d10a6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CYP24A1 ACSF2 RASGEF1B CSMD1 ACSM2A ACSM2B

3.43e-051821496e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CYP24A1 ACSF2 RASGEF1B CSMD1 ACSM2A ACSM2B

3.43e-05182149657bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYCP2 HMCN1 PKHD1 DMD CSMD1 USH2A

3.65e-0518414962cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYCP2 HMCN1 PKHD1 DMD CSMD1 USH2A

3.65e-051841496ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYCP2 HMCN1 PKHD1 DMD CSMD1 USH2A

3.65e-0518414962b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CPEB2 FAM20C PKHD1 DMD PID1 TNS3

3.76e-0518514961d874608aa2062024323512f68889219471b2f00
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHL1 LAMB1 ITGB8 FBLN2 DMD PLXNB3

3.87e-0518614966f88b68735d0f7c9904eb8413e6007910d556185
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4L ACSF2 FAM20C PKHD1 ACSM2A ACSM2B

3.87e-0518614965784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ACSF2 FAM20C PKHD1 TRPV4 ACSM2A ACSM2B

3.99e-0518714963ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 LAMB1 DNAH14 PKHD1 PID1 TNS3

3.99e-051871496c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 TRIO ITGB8 DNAH14 PKHD1 TNS3

4.11e-05188149663a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIO ITGA9 TRAF4 CSMD1 TNR PID1

4.11e-051881496a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIO ITGA9 TRAF4 CSMD1 TNR PID1

4.11e-051881496c8530c9ff98666c64a94683261af4288cb790a7e
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

CYP24A1 ITGB8 HHLA2 PKHD1 ACSM2A ACSM2B

4.23e-0518914960be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 CPEB2 ITGB8 DNAH14 ITPR3 PKHD1

4.36e-0519014963fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYCBP2 ITGA9 JAK1 HMCN1 AFDN PHLDB2

4.36e-051901496d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4L ACSF2 ITGB8 PKHD1 ACSM2A ACSM2B

4.49e-0519114963c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4L ACSF2 ITGB8 PKHD1 ACSM2A ACSM2B

4.49e-0519114961c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 ITGA9 TRAF4 KCNMB4 TNR PID1

4.49e-051911496ece87127f85939e61b1048d968ed96f0e87c3a79
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 ITGA9 TRAF4 KCNMB4 TNR PID1

4.49e-051911496478e8341ee03b05501e2233e02cef5f97492c95d
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

TRIO FBXL17 SCAPER PKHD1 ACSM2A ACSM2B

4.62e-051921496e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4L DNAH14 PKHD1 AFDN ACSM2A ACSM2B

4.76e-0519314963866667dd221612589ae50f5c52f73a183a49ce6
ToppCellStriatum-Hematopoietic-MACROPHAGE|Striatum / BrainAtlas - Mouse McCarroll V32

CXCR3 ARHGAP9 TNFRSF17 CLTA TRPV4

4.82e-05118149554930a3faa055bda4a707b93d790b2ac5a360211
ToppCellStriatum-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)|Striatum / BrainAtlas - Mouse McCarroll V32

CXCR3 ARHGAP9 TNFRSF17 CLTA TRPV4

4.82e-05118149518f9c1759df9504962612ec741638ed330c33222
ToppCellStriatum-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-|Striatum / BrainAtlas - Mouse McCarroll V32

CXCR3 ARHGAP9 TNFRSF17 CLTA TRPV4

4.82e-05118149597db1193ecc885f63840663ab969468ce21cba74
ToppCellStriatum-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--|Striatum / BrainAtlas - Mouse McCarroll V32

CXCR3 ARHGAP9 TNFRSF17 CLTA TRPV4

4.82e-0511814950c2fe46dd66e0c9cdf8c2eb66874aca79592248a
ToppCellStriatum-Hematopoietic-MACROPHAGE-MP1(C1qb)|Striatum / BrainAtlas - Mouse McCarroll V32

CXCR3 ARHGAP9 TNFRSF17 CLTA TRPV4

4.82e-0511814953f8d11e09a7660af9eca5249ad698d9b638d39dd
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FAM20C SLC9C1 NBEAL2 PKHD1 TRPV4 AFDN

4.90e-05194149604bfc555743f7d8821439d05ae442d15e9886c59
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4L LAMB1 ITGB8 DNAH14 PKHD1 PLXNB1

4.90e-0519414965eaaa81f4b2535f983c424aaef00077089526a5c
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UBR4 ITGB8 HHLA2 PKHD1 ACSM2A ACSM2B

4.90e-05194149670185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FAM20C SLC9C1 NBEAL2 PKHD1 TRPV4 AFDN

4.90e-05194149669bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell(010)_cDC|World / immune cells in Peripheral Blood (logTPM normalization)

APAF1 ACSF2 ADCY6 FAM20C FBLN2 PID1

5.04e-0519514964aabb3f5ce70100e4d98d7fa9f8d12e84fb9fe3d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4L LAMB1 ITGB8 DNAH14 PKHD1 AFDN

5.04e-0519514966477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCellBAL-Severe-Epithelial-Epithelial-transitional_Epi|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CHL1 MUC16 ITGB8 PIERCE1 TMPRSS11D FUT3

5.18e-0519614963e99a367b7d817e1f1221450fcec20ad7a7c7a2a
ToppCellBAL-Severe-Epithelial-Epithelial-transitional_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CHL1 MUC16 ITGB8 PIERCE1 TMPRSS11D FUT3

5.18e-0519614961efacc37bbfbd05b5d4db3dd10f6d9a238d23e31
ToppCellSevere_COVID-19-Epithelial-transitional_Epi|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

CHL1 MUC16 ITGB8 PIERCE1 FUT3 PLXNB1

5.33e-0519714965ad3cd4c77016e862041baac3076f8cc0f75c417
ToppCellBAL-Severe-Epithelial-Epithelial-transitional_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CHL1 MUC16 ITGB8 PIERCE1 TMPRSS11D FUT3

5.33e-05197149608b371309cd790b171ed76cabc7d910e71cd2835
ToppCellBAL-Severe-Epithelial-Epithelial-transitional_Epi|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CHL1 MUC16 ITGB8 PIERCE1 TMPRSS11D FUT3

5.33e-0519714969f49feee38647bbf964974aac96fa75602186b5c
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHL1 LRRTM1 FBLN2 NRXN2 KCNMB4 TNS3

5.48e-05198149652ddc1f1ed4ac4c3bac794c90b8feb03e3c221c4
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CHL1 MUC16 SUV39H2 ITGB8 TRPV4 HBM

5.48e-0519814961fe60443c11d34b6d2671af8f06e0dedc8d1558b
ToppCellMild/Remission-B_intermediate-0|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TRAF4 FBLN2 FTH1 AFDN NXPH4 TNS3

5.64e-051991496592111591f0f6816fc56620cb555eb48dabf0758
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

TRIO VWA8 FBXL17 RASGEF1B SCAPER DMD

5.64e-05199149694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellFrontal_cortex-Neuronal|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CHL1 NEXMIF CDKL5 CADPS TCF25 CAMTA1

5.64e-051991496f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ITGA9 NBEAL2 PKHD1 PLXNB1 PHLDB2 TNS3

5.80e-052001496ddfb1f006365bf16203ee49f20200f68220cc288
ToppCellBAL-Severe-Epithelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CHL1 MUC16 PIERCE1 AFDN FUT3 PLXNB1

5.80e-0520014960cc7ff7b6a4eb05d2370ec2f3b9dbfe8cb0699de
ToppCellBAL-Severe-Epithelial-Epithelial|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CHL1 MUC16 PIERCE1 AFDN FUT3 PLXNB1

5.80e-052001496b9cede2e0939c6b60ce1aa16d7efaaae79354580
ToppCellKidney|World / Skin and Kidney Cells in Lupus Nephritis Patients.

NEDD4L PKHD1 ACSM2A TNS3 ACSM2B GP2

5.80e-0520014961f99afa1f3c32a2a9cfb4ad33ff4d404e34fac63
ToppCellBAL-Severe-Epithelial|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CHL1 MUC16 PIERCE1 AFDN FUT3 PLXNB1

5.80e-052001496b762bf6f432eac05a476f6e2ab4da27dd13a2317
ToppCellBAL-Severe-Epithelial-Epithelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CHL1 MUC16 PIERCE1 AFDN FUT3 PLXNB1

5.80e-0520014964c63204e0d868dd4c11c1604a238624a3ad54485
ToppCellSevere_COVID-19-Epithelial|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

CHL1 MUC16 PIERCE1 AFDN FUT3 PLXNB1

5.80e-05200149649910efb6d888c208cd50530b03af19f87070630
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_activate-7|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CHL1 NEXMIF FGF23 DMD TNR

6.59e-051261495518a6e4919981b556ce6b451a91270dba976bc75
ToppCellmoderate-Epithelial-unknown_epithelial|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TRIO RBL1 MUC16 SLC38A2 PLXNB1

1.01e-041381495afefa8233c67aa744e939156bc538449bf6bd05b
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC9C1 TMPRSS11D PKHD1 USH2A ACSM2B

1.28e-04145149596712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CXCR3 SLAMF1 ITPR3 SLC38A2 EML5

1.55e-041511495e1ffd99001b6a5b795f3367882a9355955c0e569
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

RPP21 NEDD4L CYP24A1 ITGA9 PLXNB1

1.85e-0415714956ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G3 PLA2G2C SYCP2 AFDN ACSM2B

2.14e-041621495465cb483f41023d6125ea147e16f404d8e8dc9bb
ToppCell356C-Lymphocytic-NK_cells-NK_cell_B1|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ADAM20 DNAH14 HMCN1 PLXNB1

2.17e-048814941ca0e16981e88030987412e12838a9797b97b9c9
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA9 RASGEF1B FTH1 TNR ABHD12

2.27e-041641495758e85e2f5e7236b345e16c78344d5e0bf17d8dc
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIO LRRTM1 ITGA9 TRAF4 TNR

2.27e-0416414950853e75b60b2a78257b660910c3ee15b09c5f5b0
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA9 RASGEF1B FTH1 TRPV4 ABHD12

2.40e-04166149591eeb48680dd07ae4115afacdc0a8f6fa18885e5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLRP12 CYP24A1 CADPS RASGEF1B CSMD1

2.47e-0416714953edb0570e583bb527165bcd8a4c25a042054043b
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA9 FBLN2 RASGEF1B TRPV4 IFT122

2.47e-041671495f01b96173deda0239fa482989873cf308e49d48c
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA9 FBLN2 RASGEF1B TRPV4 IFT122

2.47e-0416714955fc85a05124cd2324e1b8ff940193880f83cd8af
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEXMIF LAMB1 ITPR3 CSMD1 TNR

2.68e-041701495a121e10099faaeb60251eec162f38caf7c4238c2
ComputationalNeighborhood of MAGEA9

CMKLR2 CYP2D6 PSD NEDD4L TRIO RBBP7 ADAM20 CPZ CDKL5 SCAPER ATXN3 ERC2-IT1 DMD CAMTA1

6.73e-064238714MORF_MAGEA9
ComputationalNeighborhood of SUPT3H

CMKLR2 CYP2D6 PSD NEDD4L TRIO RBBP7 ADAM20 CDKL5 ATXN3 ERC2-IT1 DMD CAMTA1

1.21e-053288712MORF_SUPT3H
ComputationalNeighborhood of RAD51L3

CMKLR2 CYP2D6 PSD NEDD4L TRIO RBBP7 ADAM20 CPZ CDKL5 ATXN3 ERC2-IT1 DMD CAMTA1

1.27e-053878713MORF_RAD51L3
ComputationalNeighborhood of CTSB

CMKLR2 PSD TRIO RBBP7 ADAM20 CDKL5 ATXN3 DMD CAMTA1

1.92e-05187879MORF_CTSB
ComputationalNeighborhood of IFNA1

CMKLR2 PSD RBBP7 ADAM20 CDKL5 ATXN3 ERC2-IT1 DMD CAMTA1

3.97e-05205879MORF_IFNA1
ComputationalNeighborhood of ATF2

CMKLR2 PSD NEDD4L TRIO RBBP7 ADAM20 CDKL5 ATXN3 ERC2-IT1 DMD CAMTA1

6.73e-053308711MORF_ATF2
ComputationalNeighborhood of PTPRR

CMKLR2 ADAM20 CDKL5 ATXN3 DMD CAMTA1

1.71e-04102876MORF_PTPRR
ComputationalNeighborhood of MDM2

CMKLR2 PSD TRIO RBBP7 ADAM20 CDKL5 ATXN3 ERC2-IT1 DMD

4.10e-04279879MORF_MDM2
ComputationalNeighborhood of CAMK4

CMKLR2 CYP2D6 PSD NEDD4L TRIO ADAM20 ATXN3 ERC2-IT1 DMD

5.43e-04290879MORF_CAMK4
ComputationalNeighborhood of MAP2K7

CMKLR2 PSD TRIO RBBP7 ADAM20 ATXN3 DMD

6.43e-04181877MORF_MAP2K7
ComputationalNeighborhood of CDH4

CMKLR2 PSD TRIO ADAM20 ATXN3 DMD

8.01e-04136876MORF_CDH4
ComputationalNeighborhood of IL4

CMKLR2 PSD TRIO ADAM20 CDKL5 ATXN3 DMD

9.10e-04192877MORF_IL4
ComputationalNeighborhood of MAGEA8

CMKLR2 PSD NEDD4L ADAM20 ATXN3 ERC2-IT1 DMD CAMTA1

1.18e-03260878MORF_MAGEA8
ComputationalNeighborhood of PAX7

CMKLR2 CYP2D6 PSD TRIO ADAM20 CPZ SCAPER ATXN3

1.37e-03266878MORF_PAX7
ComputationalNeighborhood of FSHR

CMKLR2 TRIO RBBP7 ADAM20 ATXN3 ERC2-IT1 DMD CAMTA1

1.85e-03279878MORF_FSHR
DiseaseX-21319 measurement

ACSM2A ACSM2B

2.43e-0521462EFO_0800807
DiseaseX-11478 measurement

ACSM2A ACSM2B

7.27e-0531462EFO_0021242
Diseaselevel of killer cell immunoglobulin-like receptor 2DS2 in blood serum

KIR3DL3 KIR2DL1

7.27e-0531462OBA_2042107
DiseaseNoonan syndrome (implicated_via_orthology)

LZTR1 APAF1

1.45e-0441462DOID:3490 (implicated_via_orthology)
Diseasesolanidine measurement

CYP2D7 CYP2D6

1.45e-0441462EFO_0800966
DiseaseMachado-Joseph disease (implicated_via_orthology)

ATXN3L ATXN3

1.45e-0441462DOID:1440 (implicated_via_orthology)
Diseaseresponse to bevacizumab, Proteinuria

TRIO JAK1

2.41e-0451462EFO_0005943, HP_0000093
Disease3-hydroxyhexanoate measurement

ACSM2A ACSM2B

2.41e-0451462EFO_0800378
Diseaseindoleacetoylcarnitine measurement

ACSM2A ACSM2B

3.60e-0461462EFO_0800106
Diseasenischarin measurement

NLRP12 NISCH

3.60e-0461462EFO_0801841
DiseaseAchromatopsia

RPGR GNAT2

5.02e-0471462C0152200
DiseaseFEV change measurement, fatty liver disease

CLTA CAMTA1

6.68e-0481462EFO_0005921, MONDO_0004790
Diseasetuberculosis

CXCR3 VWA8 RBL1 DMD CSMD1 TNR

7.43e-042161466MONDO_0018076
Diseasefat body mass

MYCBP2 CXCR5 PPP3CA CADPS SECISBP2 NXPH4

7.61e-042171466EFO_0005409
DiseaseMalignant neoplasm of breast

CYP2D6 CYP24A1 UBR4 COG3 ITGA9 HELQ SLAMF1 SUV39H2 CXCR5 PER3 NISCH ZFYVE26 DMD PLXNB1

9.22e-04107414614C0006142
DiseaseEczema

CYP24A1 SLAMF1 ITGB8 ITPR3 CXCR5 JAK1 ANAPC1

9.23e-043101467HP_0000964
DiseaseNeurodevelopmental Disorders

TRIO NEXMIF CDKL5 PLXNB1

1.19e-03931464C1535926
DiseaseTremor

CYP2D6 ABHD12

1.30e-03111462C0040822
Diseaseglycerophosphorylcholine measurement

JAK1 EPHA8

1.30e-03111462EFO_0020018
DiseaseSchizophrenia

CHL1 IPO5 CYP2D6 PSD LRRTM1 TRRAP SLC38A2 SETDB1 EML5 NRXN2 ERVK-8 CSMD1

1.52e-0388314612C0036341
Diseasesevere acute respiratory syndrome, COVID-19

ACSF2 HELQ CADPS RASGEF1B DMD CAMTA1 CSMD1 TNR

1.78e-034471468EFO_0000694, MONDO_0100096
DiseaseRetinitis Pigmentosa

SCAPER RPGR USH2A ABHD12

1.80e-031041464C0035334
Diseasesquamous cell carcinoma, multiple keratinocyte carcinoma susceptibility measurement, basal cell carcinoma

PKHD1 CSMD1

1.83e-03131462EFO_0000707, EFO_0004193, EFO_0007932
DiseaseHypoxanthine measurement

AMIGO1 PKHD1

1.83e-03131462EFO_0021604
Diseaseillegal drug consumption

ITGA9 CSMD1

1.83e-03131462EFO_0005431
Diseaseautoimmune hepatitis (is_implicated_in)

CYP2D6 KIR2DL2

1.83e-03131462DOID:2048 (is_implicated_in)
Diseaseearly cardiac repolarization measurement

MYCBP2 HBM

2.13e-03141462EFO_0004885
DiseaseCiliopathies

PKHD1 RPGR USH2A INVS

2.21e-031101464C4277690
Diseaseserum selenium measurement

PKHD1 CEP152 CSMD1

2.32e-03531463EFO_0005266
DiseaseMetastatic melanoma

TRIO CDKL5 EPHA8

2.45e-03541463C0278883
Diseasekiller cell immunoglobulin-like receptor 2DS2 measurement

KIR3DL3 KIR2DL1

2.45e-03151462EFO_0801746
Diseasegalectin-3 measurement

NLRP12 FUT3

2.79e-03161462EFO_0008137
DiseaseEye Abnormalities

APAF1 IFT122

3.15e-03171462C0015393
DiseaseCharcot-Marie-Tooth disease type 2

TRPV4 DYNC1H1

3.15e-03171462cv:C0270914
Diseaseinsulin sensitivity measurement, body mass index

CYP24A1 GP2

3.93e-03191462EFO_0004340, EFO_0004471
Diseasereasoning

ZFP90 PID1

3.93e-03191462EFO_0004350
Diseaseage at menopause

RNF44 FBXL17 HELQ TCF25 ABHD12 DYNC1H1

4.01e-033021466EFO_0004704
DiseaseDisorder of eye

RPGR GNAT2 USH2A ABHD12 INVS

4.16e-032121465C0015397
Diseaseeye colour measurement

MYCBP2 AMIGO1 PPP3CA USH2A TNS3

4.67e-032181465EFO_0009764
DiseaseAntimigraine preparation use measurement

FGF23 PID1

4.80e-03211462EFO_0009939

Protein segments in the cluster

PeptideGeneStartEntry
VECHPYLNQSKLLDF

AKR1C4

191

P17516
LQLQALLQNYHCAPD

AFDN

876

P55196
STIQYCDFSPQNHLA

APAF1

841

O14727
ERLNATHCQYNFPQV

CXCR3

196

P49682
LLFPCHRLASQNYSD

ERC2-IT1

91

O76042
LYLHNNPLNCDCELY

AMIGO1

216

Q86WK6
NPLNCDCELYQLFSH

AMIGO1

221

Q86WK6
ILNSIYQCPEHSQLT

APOM

16

O95445
SKCEQTDLYHLPENF

CEP152

136

O94986
QACSSEHYLQPETNG

CAMTA1

711

Q9Y6Y1
YFHHQEQPLQNFLCE

CNPY4

171

Q8N129
SDFCITPQIYNDSEH

ERVK-8

556

Q902F8
CLRHSPEYFSQAQTL

ANTXRL

556

A6NF34
NYNDTSLVENHLCPA

CXCR5

26

P32302
NITYTTFGQNECHDP

CSMD1

686

Q96PZ7
HALLQDQPFIQDDCY

ADAM20

96

O43506
PADITACHLQQLNYS

ADCY6

781

O43306
RHIILYSNNSPCNEA

APOBEC4

116

Q8WW27
QDLSSYKFPHLQNCV

ACSM2A

321

Q08AH3
VPYTFHLNQGDDNCL

C1orf74

181

Q96LT6
QYNQQFLSCHDPINI

ACSF2

246

Q96CM8
LIQHYCQSLNQDSPL

DMD

3471

P11532
QLYNPSFDCHVSEPN

AHDC1

1126

Q5TGY3
QVFNASLQDHIYPSC

FAM193A

501

P78312
YDPSQVCFTEHTQSQ

NXPH4

251

O95158
SPLCHNLFALYDENT

JAK1

71

P23458
CENYNTVSPSQLLDF

PARPBP

121

Q9NWS1
NYQLCSEISEPVLQH

ITPR3

1271

Q14573
SCQPVLNSYQFHIVN

PLA2G2C

76

Q5R387
GLNHTCNYYLQPEED

ABHD12

121

Q8N2K0
LHDSLYNEDCTFQQL

ANAPC1

566

Q9H1A4
FEHQLLYNACQLDNP

CADPS

286

Q9ULU8
QQCPGYYQSHLDLED

MUC16

14491

Q8WXI7
TSCDRLNFHPSYNIN

PIERCE1

116

Q5BN46
DPQEVTYTQLNHCVF

KIR2DL2

296

P43627
THNDAIQCVSYNPIT

IFT122

91

Q9HBG6
TLPNELHCYDVDFQT

LZTR1

306

Q8N653
LQPNHTAVYQCEASN

CHL1

391

O00533
YCEALNLTEAPHNLS

LRRTM1

51

Q86UE6
QSLNPHNDYCQHFVD

METTL14

111

Q9HCE5
NHYQPQTLCINFDDA

KIAA1109

216

Q2LD37
QHCLNNLLQGEYFSP

ATXN3

16

P54252
QHCLNNLLQGEYFSP

ATXN3L

16

Q9H3M9
FLECQNSPARITHYQ

FBLN2

1076

P98095
IAYCTADHNVSPNIF

PID1

166

Q7Z2X4
RNDEHSPSYQQINCI

PER3

526

P56645
CQQHQLSYEALQPEL

PLXNB1

981

O43157
NYTSAPHCLEALQEL

PLXNB3

1851

Q9ULL4
NEVNHFYCDLPQLFQ

OR3A2

181

P47893
NEVNHFYCDLPQLFQ

OR3A3

181

P47888
AERHNCQYPENILSF

NEMP2

86

A6NFY4
PQEVTYAQLNHCVFT

KIR3DL3

376

Q8N743
SVCLYSPLAEQFSHQ

NPRL3

341

Q12980
AHVCFDPCQNYTLLD

GP2

56

P55259
DTILNINFQCAYPLD

GP2

311

P55259
SEHVSLSCQPVNDYF

HHLA2

236

Q9UM44
EFFCYDLSHNPIQSS

NRXN2

296

Q9P2S2
DNLPCLQHLFLSFNN

LRRC49

241

Q8IUZ0
CFICNSQDPYHETLN

LAMB1

76

P07942
QTFNYLCDLIESNHP

IPO5

1011

O00410
TVCNDPYTLAQQLTH

RASGEF1B

201

Q0VAM2
SDFCITPQIYNESEH

ERVK-7

1316

P63135
AHTAEVNCLSFNPYS

RBBP4

271

Q09028
HTAEVNCLSFNPYSE

RBBP7

271

Q16576
GHYTVNENSQAILPC

HMCN1

4176

Q96RW7
NSNIIQHFYCDIIPL

OR5H6

186

Q8NGV6
SNIINHFYCDDVPLL

OR8J2

171

Q8NGG1
ANFIQLDDLECHFQP

ITGA9

791

Q13797
QQHYVDQTSECFSSP

ITGB8

666

P26012
SNIINHFYCDNVPLL

OR8J1

171

Q8NGP2
NDPHLCDFIETHYLN

FTH1

126

P02794
YEFCPFHNVTQHEQT

GNPTG

81

Q9UJJ9
VNVSSLSGHNYLCPN

KLRF2

66

D3W0D1
CSDAAYNHTTFPNLL

CPZ

51

Q66K79
VLNSPTCYSAHQNGE

CPEB2

311

Q7Z5Q1
QPSADFLCDIYHQNR

CYP24A1

296

Q07973
SDFCITPQIYNESEH

ERVK-25

556

P61570
SDFCITPQIYNESEH

ERVK-6

556

Q69384
YSHDELSILVPLQQC

FAM20C

486

Q8IXL6
LLHVDFQNTPYCFDQ

CYP2D6

46

P10635
IPEYQQLLNDIHQCY

COG3

321

Q96JB2
HYFDPENCRFQHQTL

FGF23

106

Q9GZV9
QQYPHITFSTVLQDC

FBXL17

666

Q9UF56
DESFQPIHTYQVCNV

EPHA8

61

P29322
TYPSNILSHEQSNFC

CENPJ

231

Q9HC77
CHILFETDPAYQNII

DNAH14

651

Q0VDD8
QVADNFSRQYSHLCP

DRC7

96

Q8IY82
QCIQEALREHSNPNY

DYNC1H1

1976

Q14204
FTCYFNQHQRPDDVL

KCNMB4

146

Q86W47
VIQYNLDQSCLPHDI

KLHDC3

346

Q9BQ90
SDFCITPQIYNESEH

HERVK_113

556

Q902F9
SQSFYQEHNDDILCL

EML5

1406

Q05BV3
TKPLENCYSHLVQEF

HELQ

736

Q8TDG4
VYFPHLSACQDATQL

HBM

41

Q6B0K9
NPQDQHTDAICSVNY

CSTF1

256

Q05048
YLTEQCLNHPTFQTQ

CDKL5

286

O76039
VLFPSLIAACYNNHQ

SCAPER

1316

Q9BY12
QLTNLACSFSQAYHP

METTL17

341

Q9H7H0
DPQEVTYTQLNHCVF

KIR2DL1

296

P43626
SYPAVCEFLQHNNLL

PPP3CA

261

Q08209
ENQPDFTAANVYHLL

MTBP

36

Q96DY7
CNITSYDNLFRTPLH

INVS

246

Q9Y283
LENFTNHFIPTLCSN

RPGR

331

Q92834
PNCQHLEALDRYFNL

FUT3

141

P21217
QCEPHRYNLTIDNFQ

USH2A

881

O75445
HFSQRYFQCNPEALS

PSD

631

A5PKW4
HLYDAFEQCSPLIKQ

SLC9C1

981

Q4G0N8
ETFCQHYTQSTDEQP

RBL1

436

P28749
TQLPSDDSYQLCHFN

NEXMIF

956

Q5QGS0
PVLQATFLSNNCFEH

NBEAL2

321

Q6ZNJ1
VHLSICFPEYDGNNS

GNAT2

281

P19087
QHADNIYICTVSNPI

SLAMF1

201

Q13291
FLYQAAHCVLAQDPE

RPP21

16

Q9H633
LHTIIDYACEQNIPF

SECISBP2

711

Q96T21
LHSNPSAFNIYCNVR

MYCBP2

141

O75592
DDQLPCNVTFFNASH

PKHD1

1521

P08F94
FPAGCSEESYLHNLQ

TNS3

21

Q68CZ2
LPHSVIDNDNYLNFS

PHLDB2

291

Q86SQ0
EFQLLNSAQEPLFHC

PLA2G3

381

Q9NZ20
FVNHSCDPNLQVYNV

SUV39H1

321

O43463
YLNHSCSPNLFVQNV

SETDB1

1221

Q15047
QDLSSYKFPHLQNCL

ACSM2B

321

Q68CK6
LCYNNFQKHDPDLTL

CMKLR2

186

P46091
TNINHPCYSLEQAAE

CLTA

181

P09496
LLHVDFQNTPYCFDQ

CYP2D7

46

A0A087X1C5
IISNDVCNAPHSYNG

TMPRSS11D

331

O60235
SPQLQHNITEDAYCE

TRIML2

6

Q8N7C3
QVFNSYIQCHLAAPD

XPO4

431

Q9C0E2
QYLCQFCEHETNDPE

ZNF639

316

Q9UID6
LCFQHNTPLDAIAQF

TRAPPC11

281

Q7Z392
LDQAYTPNFLHCKDS

REV3L

1411

O60673
NPNNHLQLYSCSLDG

WDR75

66

Q8IWA0
TENDSCRPHYFIFNS

SLC38A2

276

Q96QD8
VTSECPVNDVYNFNL

SYCP2

861

Q9BX26
CPLLLQQFSNDKHNY

SUV39H2

86

Q9H5I1
YRFNPDSHQSEQTLC

RNF44

366

Q7L0R7
LSCLHQNQDEELFYC

nan

186

Q6ZSR6
NTDYNNSPFHISQCF

NISCH

1211

Q9Y2I1
NHVYNINVPLDNLCS

TNR

66

Q92752
ELPDDYSCLLNQASH

UBR1

1596

Q8IWV7
QHLDPNSGRCFYINS

ARHGAP9

221

Q9BRR9
EFVFDTIQSHQYQCP

TRAF4

201

Q9BUZ4
PEQENILHTTQTDCY

TTC9C

61

Q8N5M4
NLPCNHSTISGNEYV

TRAV26-1

36

A0A087WT03
LSDPNNYHEFCRLLA

XPO7

321

Q9UIA9
NYPPHLLQECSADAQ

ZBTB49

151

Q6ZSB9
QHVDNYLLLQPFCTK

TOGARAM1

1601

Q9Y4F4
QYPNENLHSAVTKAC

VWA8

671

A3KMH1
TGCYNILANHADPNS

UBR4

1356

Q5T4S7
NEYFDSLLHACIPCQ

TNFRSF17

11

Q02223
QLSSLNPQERIDYCH

TOPBP1

1271

Q92547
PEHLSQCQNLTLYQG

ZFYVE26

486

Q68DK2
LCVDNLQPDFLYDHI

TRRAP

851

Q9Y4A5
YFLLSQQTDLPECEQ

TCF25

426

Q9BQ70
LAACTNQPHIVNYLT

TRPV4

291

Q9HBA0
SQLTPEFDGCLEYNH

TRIO

196

O75962
IHTAENPYDCEQAFS

ZFP90

471

Q8TF47
YSEHLAAALCTNPNL

NLRP12

701

P59046
PICDSAISVHNFNYQ

NEUROD4

191

Q9HD90
NPNSGLCNEDHLSYF

NEDD4L

696

Q96PU5