Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	ACIN1 SAFB	9.15e-04	21	40	2	1.10.720.30
Domain	SAP	ACIN1 SAFB	1.01e-03	22	40	2	PF02037
Domain	SAP	ACIN1 SAFB	1.10e-03	23	40	2	SM00513
Domain	SAP	ACIN1 SAFB	1.30e-03	25	40	2	PS50800
Domain	SAP_dom	ACIN1 SAFB	1.30e-03	25	40	2	IPR003034
Domain	-	LRP1 ALK	4.36e-03	46	40	2	4.10.400.10
Domain	LDLRA_1	LRP1 ALK	4.74e-03	48	40	2	PS01209
Domain	LDrepeatLR_classA_rpt	LRP1 ALK	4.94e-03	49	40	2	IPR002172
Domain	LDLa	LRP1 ALK	4.94e-03	49	40	2	SM00192
Domain	LDLRA_2	LRP1 ALK	4.94e-03	49	40	2	PS50068
Pubmed	The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation.	ACIN1 API5	1.56e-06	2	44	2	19387494
Pubmed	Biochemical characterization of human acyl coenzyme A: 2-monoacylglycerol acyltransferase-3 (MGAT3).	MGAT3 DGAT2	9.37e-06	4	44	2	27184406
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	FLG ACIN1 KRT78 SAFB SF3B1 API5 FAM120A	1.02e-05	605	44	7	28977666
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	ACIN1 SAFB SF3B1 ZFC3H1	5.45e-05	163	44	4	22113938
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	TRIOBP FLG ACIN1 KRT78 SAFB SF3B1 DERL1 CPEB4	5.60e-05	1082	44	8	38697112
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	ACIN1 SAFB SF3B1 ZCCHC13 CPEB4	7.58e-05	347	44	5	16033648
Pubmed	RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.	ACIN1 SAFB API5 ZFC3H1	8.54e-05	183	44	4	28186131
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	ACIN1 SAFB SF3B1 ZFC3H1	1.25e-04	202	44	4	24639526
Pubmed	Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.	TRIOBP MYO15A	1.41e-04	14	44	2	26754646
Pubmed	RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.	TRIOBP MYO15A	1.63e-04	15	44	2	36260679
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	ACIN1 SAFB SF3B1 FAM120A	2.57e-04	244	44	4	29884807
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	TRIOBP FLG KRT78 SF3B1 TXNDC5	3.69e-04	488	44	5	31324722
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	GAS2L1 KRT78 SAFB MGAT3 SF3B1 FAM120A KCTD13 CPEB4	3.81e-04	1431	44	8	37142655
Pubmed	Proteomic data on the nuclear interactome of human MCM9.	API5 MCM8	3.89e-04	23	44	2	26870752
Pubmed	MCM9 Is Required for Mammalian DNA Mismatch Repair.	API5 MCM8	3.89e-04	23	44	2	26300262
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	ACIN1 SAFB SF3B1 FAM120A ARAF	4.23e-04	503	44	5	16964243
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	LRP1 ACOT8 FAM120A MCM8 PHLDA1 ARAF CPEB4	4.67e-04	1116	44	7	31753913
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ACIN1 SAFB SF3B1 API5 FAM120A CPEB4	5.10e-04	807	44	6	22681889
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	LRP1 SF3B1 KCTD13 MYO15A	5.83e-04	303	44	4	25056061
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	ACIN1 SAFB SF3B1	6.04e-04	130	44	3	35545047
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	SAFB SF3B1 API5 FAM120A TXNDC5	6.39e-04	551	44	5	34728620
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	LRP1 SAFB SF3B1 ZFC3H1 TXNDC5 DERL1 PHLDA1	7.28e-04	1203	44	7	29180619
Pubmed	Large-scale concatenation cDNA sequencing.	SF3B1 FAM120A GLS2 DERL1 ARAF	7.33e-04	568	44	5	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	SF3B1 FAM120A GLS2 DERL1 ARAF	7.68e-04	574	44	5	8619474
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	LRP1 MGAT3 SF3B1 CREG1 ARAF	1.03e-03	613	44	5	22268729
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	KRT78 SAFB SF3B1 ZFC3H1	1.12e-03	361	44	4	26167880
GeneFamily	Actins\|Deafness associated genes	TRIOBP MYO15A	1.32e-02	113	28	2	1152
Computational	Neighborhood of SNRP70	SAFB API5 ZFC3H1	1.40e-04	62	18	3	MORF_SNRP70
Disease	threonine measurement	GLS2 CPEB4	1.10e-03	37	39	2	EFO_0009775
Disease	total cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement	MACROD1 CPEB4	1.92e-03	49	39	2	EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	TRIOBP MYO15A	2.08e-03	51	39	2	cv:CN043650
Disease	HDL cholesterol change measurement, physical activity	MACROD1 DGAT2	3.06e-03	62	39	2	EFO_0003940, EFO_0007805
Disease	cardiomyopathy (implicated_via_orthology)	LRP1 ARAF	3.99e-03	71	39	2	DOID:0050700 (implicated_via_orthology)
Disease	Nonsyndromic genetic hearing loss	TRIOBP MYO15A	4.56e-03	76	39	2	cv:C5680182
Disease	smoking behavior, BMI-adjusted waist-hip ratio	MACROD1 CPEB4	5.80e-03	86	39	2	EFO_0004318, EFO_0007788
Disease	urate measurement	MACROD1 LRP1 GLS2 DGAT2 CPEB4	6.22e-03	895	39	5	EFO_0004531
Disease	hearing impairment	TRIOBP MYO15A	7.47e-03	98	39	2	C1384666
Disease	BMI-adjusted waist-hip ratio, sex interaction measurement, age at assessment	MACROD1 CPEB4	8.53e-03	105	39	2	EFO_0007788, EFO_0008007, EFO_0008343

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSGRGHLGTFEGRWR	ACIN1	26	Q9UKV3
GGWVLIDRSGRHFGT	KCTD13	81	Q8WZ19
ESPWAGGSRGLVHGR	ACOT8	276	O14734
RHGRWSRGEGGESGL	LINC00696	46	Q6ZRV3
GRDWLGGGPRATHGH	FAM220BP	121	B1ANY3
GWGRGLHRRGLGRAE	C19orf84	116	I3L1E1
GAFRGSRGGRGWGTR	API5	501	Q9BZZ5
HGWTGPSTRGRQGSR	FLG	3076	P20930
CSLGGGSVWGHRSFR	CCNP	276	Q9H8S5
QTFSGSWERRHGGGG	CCM2L	241	Q9NUG4
QAGSGGGGSWERRHP	CCM2L	271	Q9NUG4
AGSGSWHSERGEGRG	ANKRD53	11	Q8N9V6
GGRGGWIMRSGDRDH	OR1F12P	321	Q8NHA8
GRGRFQSWKRGRGGG	MCM8	11	Q9UJA3
RSTAAGGWRHRGPEG	MGAT3	506	Q09327
GPDFGWRFGTIHGRV	MYO15A	2926	Q9UKN7
AGRRTVHRETGSGGW	LRP1	1421	Q07954
RFWEVGGGSGHRLER	LONRF1	26	Q17RB8
RPVWAGHGGAGGTDR	EVPLL	121	A8MZ36
GGGRHNWGQGFRLGD	DERL1	236	Q9BUN8
SRGSTWGSGGRLGVR	KRT78	51	Q8N1N4
LSRAGSHCGRGGWGH	GLS2	11	Q9UI32
GTVVGHWAGSRRGRG	FAM120A	951	Q9NZB2
HWAGSRRGRGGRGPF	FAM120A	956	Q9NZB2
IGTGSFGTVFRGRWH	ARAF	316	P10398
RDGQHSWVPRGRGSG	GAS2L1	451	Q99501
FGRRARTSAGVGAWG	MACROD1	51	Q9BQ69
ERAHGGGFVWGRSAR	INPP5B	216	P32019
YGGWGGSQGRDHRRG	CPEB4	306	Q17RY0
FGEHRLGGDGRGWVR	ENGASE	436	Q8NFI3
VSPARGRGGRDHGDW	CREG1	26	O75629
TWGRERQSAGGGRGA	B3GNT7	156	Q8NFL0
EGYSVGRGGRWRGTS	DDX43	41	Q9NXZ2
SHGGPALSREGSGRW	DGAT2	26	Q96PD7
ARLRGARWGSGRHGA	LTB4R2	206	Q9NPC1
ARWGSGRHGARVGRL	LTB4R2	211	Q9NPC1
TGGGGRSAGQHWARL	TRIOBP	211	Q9H2D6
GPERHGRDSRDGWGG	SAFB	786	Q15424
RVNRSVHEWAGGGGG	ALK	806	Q9UM73
RAGGRGSRWGEDGAR	PHLDA1	101	Q8WV24
HGSGWAETPRTDRGG	SF3B1	306	O75533
HQGREGGGRRAWQTL	STPG3	131	Q8N7X2
HSGHWARGCPRGGAG	ZCCHC13	11	Q8WW36
GGRRSGHGAVRSWGP	nan	116	Q6ZS52
LGHGGGGRWGARAQE	TXNDC5	26	Q8NBS9
YRGGSRWSRGRGVGE	ZFC3H1	151	O60293
GGREGALRTPAGGWH	WDR81	6	Q562E7
TRAAGGRFHWFGDTG	VWA3A	676	A6NCI4