Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	K63-linked deubiquitinase activity	ATXN3L ATXN3 USP27X	2.43e-05	16	72	3	GO:0061578
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1S SCN11A STIM2 SCN2A SCN9A LRRC8B LRRC8D RYR1 RYR2	3.91e-05	459	72	9	GO:0005216
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	ATXN3L ATXN3 USP27X	5.71e-05	21	72	3	GO:1990380
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	7.66e-05	4	72	2	GO:0005219
GeneOntologyMolecularFunction	channel activity	CACNA1S SCN11A STIM2 SCN2A SCN9A LRRC8B LRRC8D RYR1 RYR2	1.10e-04	525	72	9	GO:0015267
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN11A SCN2A SCN9A	1.10e-04	26	72	3	GO:0005248
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1S SCN11A STIM2 SCN2A SCN9A LRRC8B LRRC8D RYR1 RYR2	1.11e-04	526	72	9	GO:0022803
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	1.91e-04	6	72	2	GO:0048763
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1S SLC8A3 STIM2 RYR1 RYR2	2.15e-04	151	72	5	GO:0015085
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1S SCN11A STIM2 SCN2A SCN9A RYR1 RYR2	2.35e-04	343	72	7	GO:0005261
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1S SCN11A SLC8A3 STIM2 SCN2A SCN9A RYR1 RYR2	2.64e-04	465	72	8	GO:0046873
GeneOntologyMolecularFunction	volume-sensitive anion channel activity	LRRC8B LRRC8D	4.54e-04	9	72	2	GO:0005225
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1S SCN11A SLC8A3 STIM2 SCN2A SCN9A LRRC8B LRRC8D RYR1 RYR2	5.32e-04	793	72	10	GO:0015075
GeneOntologyMolecularFunction	cysteine-type peptidase activity	ATXN3L ATXN3 CASP4 USP54 USP27X	6.48e-04	192	72	5	GO:0008234
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	ATXN3L ATXN3 USP54 USP27X	7.69e-04	114	72	4	GO:0004843
GeneOntologyMolecularFunction	sodium channel activity	SCN11A SCN2A SCN9A	8.75e-04	52	72	3	GO:0005272
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1S SCN11A SLC8A3 STIM2 SLC7A13 SLC27A1 SCN2A SCN9A LRRC8B LRRC8D RYR1 RYR2	9.77e-04	1180	72	12	GO:0022857
GeneOntologyMolecularFunction	deubiquitinase activity	ATXN3L ATXN3 USP54 USP27X	1.05e-03	124	72	4	GO:0101005
GeneOntologyMolecularFunction	sodium ion binding	SCN2A SCN9A	1.13e-03	14	72	2	GO:0031402
GeneOntologyMolecularFunction	calcium channel activity	CACNA1S STIM2 RYR1 RYR2	1.22e-03	129	72	4	GO:0005262
GeneOntologyMolecularFunction	calmodulin binding	CACNA1S SLC8A3 SCN2A RYR1 RYR2	1.45e-03	230	72	5	GO:0005516
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	ATXN3L ATXN3 USP54 USP27X	1.52e-03	137	72	4	GO:0019783
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1S SCN11A SLC8A3 STIM2 SCN2A SCN9A RYR1 RYR2	1.85e-03	627	72	8	GO:0022890
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 RYR2	1.89e-03	18	72	2	GO:0015278
GeneOntologyMolecularFunction	transporter activity	CACNA1S SCN11A SLC8A3 STIM2 SLC7A13 SLC27A1 SCN2A SCN9A LRRC8B LRRC8D RYR1 RYR2	2.08e-03	1289	72	12	GO:0005215
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1S SCN11A SLC8A3 STIM2 SCN2A SCN9A RYR1 RYR2	2.63e-03	664	72	8	GO:0008324
GeneOntologyMolecularFunction	histone deacetylase activity	ATXN3L ATXN3	3.36e-03	24	72	2	GO:0004407
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SCN11A SLC8A3 SCN2A SCN9A	3.40e-03	171	72	4	GO:0015081
GeneOntologyMolecularFunction	protein lysine deacetylase activity	ATXN3L ATXN3	3.65e-03	25	72	2	GO:0033558
GeneOntologyMolecularFunction	alkali metal ion binding	SCN2A SCN9A	3.94e-03	26	72	2	GO:0031420
GeneOntologyMolecularFunction	D-mannose binding	MRC1 IGF2R	4.25e-03	27	72	2	GO:0005537
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR1 RYR2	5.57e-03	31	72	2	GO:0099604
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1S SCN11A SLC8A3 STIM2 SCN2A SCN9A RYR1 RYR2	5.84e-03	758	72	8	GO:0015318
GeneOntologyMolecularFunction	chemokine binding	CCR7 ITGA4	6.30e-03	33	72	2	GO:0019956
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR1 RYR2	6.30e-03	33	72	2	GO:0005217
GeneOntologyBiologicalProcess	cellular response to caffeine	CACNA1S RYR1 RYR2	6.88e-06	11	73	3	GO:0071313
GeneOntologyBiologicalProcess	striated muscle contraction	CACNA1S SCN11A SLC8A3 SCN2A SCN9A RYR1 RYR2	1.17e-05	217	73	7	GO:0006941
GeneOntologyBiologicalProcess	protein localization to cytosolic proteasome complex	ATXN3L ATXN3	1.24e-05	2	73	2	GO:1904327
GeneOntologyBiologicalProcess	cellular response to purine-containing compound	CACNA1S RYR1 RYR2	1.51e-05	14	73	3	GO:0071415
GeneOntologyBiologicalProcess	response to caffeine	CACNA1S RYR1 RYR2	5.40e-05	21	73	3	GO:0031000
GeneOntologyBiologicalProcess	aspartate transmembrane transport	SLC7A13 LRRC8B LRRC8D	6.24e-05	22	73	3	GO:0015810
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN11A SCN2A SCN9A RYR2	6.90e-05	62	73	4	GO:0086002
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	CACNA1S SCN11A SLC8A3 STIM2 CCR7 ADCYAP1R1 RYR1 RYR2	7.25e-05	392	73	8	GO:0070588
GeneOntologyBiologicalProcess	calcium ion transmembrane import into cytosol	CACNA1S SLC8A3 CCR7 ADCYAP1R1 RYR1 RYR2	1.20e-04	217	73	6	GO:0097553
GeneOntologyBiologicalProcess	behavioral response to chemical pain	SCN11A SCN9A	1.23e-04	5	73	2	GO:0061366
GeneOntologyBiologicalProcess	behavioral response to formalin induced pain	SCN11A SCN9A	1.23e-04	5	73	2	GO:0061368
GeneOntologyBiologicalProcess	response to nitrogen compound	ATXN3L CACNA1S SCN11A SLC8A3 MAS1L SLC27A1 ATXN3 CASP4 CCR7 PLD1 ITGA4 TOP2B RYR1 RYR2	1.28e-04	1272	73	14	GO:1901698
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	CACNA1S SCN11A SLC8A3 STIM2 SCN2A SCN9A LRRC8B CCR7 LRRC8D NNT ADCYAP1R1 RYR1 RYR2	1.31e-04	1115	73	13	GO:0034220
GeneOntologyBiologicalProcess	C4-dicarboxylate transport	SLC7A13 LRRC8B LRRC8D	1.45e-04	29	73	3	GO:0015740
GeneOntologyBiologicalProcess	protein K48-linked deubiquitination	ATXN3L ATXN3 USP27X	1.78e-04	31	73	3	GO:0071108
GeneOntologyBiologicalProcess	protein K63-linked deubiquitination	ATXN3L ATXN3 USP27X	1.96e-04	32	73	3	GO:0070536
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	SCN11A SCN2A SCN9A RYR2	2.57e-04	87	73	4	GO:0086001
GeneOntologyBiologicalProcess	intracellular calcium ion homeostasis	CACNA1S SLC8A3 STIM2 THADA CCR7 RYR1 RYR2	2.78e-04	359	73	7	GO:0006874
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN11A SCN2A SCN9A	2.79e-04	36	73	3	GO:0086010
GeneOntologyBiologicalProcess	response to purine-containing compound	CACNA1S SLC8A3 TOP2B RYR1 RYR2	3.07e-04	166	73	5	GO:0014074
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	SCN11A SCN2A SCN9A RYR2	3.32e-04	93	73	4	GO:0086003
GeneOntologyBiologicalProcess	cyclic-GMP-AMP transmembrane import across plasma membrane	LRRC8B LRRC8D	3.41e-04	8	73	2	GO:0140361
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	CACNA1S SCN11A SLC8A3 STIM2 SCN2A SCN9A CCR7 NNT ADCYAP1R1 RYR1 RYR2	3.77e-04	922	73	11	GO:0098662
GeneOntologyBiologicalProcess	cellular response to alkaloid	CACNA1S RYR1 RYR2	3.82e-04	40	73	3	GO:0071312
GeneOntologyBiologicalProcess	calcium ion transport	CACNA1S SCN11A SLC8A3 STIM2 CCR7 ADCYAP1R1 RYR1 RYR2	4.29e-04	509	73	8	GO:0006816
GeneOntologyBiologicalProcess	calcium ion transport into cytosol	SLC8A3 ADCYAP1R1 RYR2	4.42e-04	42	73	3	GO:0060402
GeneOntologyBiologicalProcess	calcium ion homeostasis	CACNA1S SLC8A3 STIM2 THADA CCR7 RYR1 RYR2	4.50e-04	389	73	7	GO:0055074
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	CACNA1S SCN11A SLC8A3 STIM2 SCN2A SCN9A CCR7 NNT ADCYAP1R1 RYR1 RYR2	4.52e-04	942	73	11	GO:0098655
GeneOntologyBiologicalProcess	muscle contraction	CACNA1S SCN11A SLC8A3 SCN2A SCN9A RYR1 RYR2	5.31e-04	400	73	7	GO:0006936
GeneOntologyBiologicalProcess	monoubiquitinated protein deubiquitination	ATXN3L ATXN3	5.46e-04	10	73	2	GO:0035520
GeneOntologyBiologicalProcess	guanine nucleotide transmembrane transport	LRRC8B LRRC8D	5.46e-04	10	73	2	GO:1903790
GeneOntologyBiologicalProcess	cyclic nucleotide transport	LRRC8B LRRC8D	6.66e-04	11	73	2	GO:0070729
GeneOntologyBiologicalProcess	guanine nucleotide transport	LRRC8B LRRC8D	6.66e-04	11	73	2	GO:0001408
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	CACNA1S SCN11A SLC8A3 STIM2 SCN2A SCN9A CCR7 NNT ADCYAP1R1 RYR1 RYR2	8.54e-04	1017	73	11	GO:0098660
GeneOntologyBiologicalProcess	response to temperature stimulus	ATXN3L SCN11A SLC27A1 SCN9A ATXN3	8.56e-04	208	73	5	GO:0009266
GeneOntologyBiologicalProcess	monoatomic ion transport	CACNA1S SCN11A SLC8A3 STIM2 SCN2A SCN9A LRRC8B CCR7 LRRC8D NNT ADCYAP1R1 RYR1 RYR2	9.73e-04	1374	73	13	GO:0006811
GeneOntologyBiologicalProcess	protein deubiquitination	ATXN3L ATXN3 USP54 USP27X	1.01e-03	125	73	4	GO:0016579
GeneOntologyBiologicalProcess	actin-mediated cell contraction	SCN11A SCN2A SCN9A RYR2	1.07e-03	127	73	4	GO:0070252
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN11A SCN2A SCN9A	2.79e-05	17	74	3	GO:0001518
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1S SCN11A SCN2A SCN9A LRRC8B LRRC8D RYR1 RYR2	5.65e-05	378	74	8	GO:0034702
GeneOntologyCellularComponent	sarcolemma	CACNA1S SLC8A3 SCN2A SGCE RYR1 RYR2	5.78e-05	190	74	6	GO:0042383
GeneOntologyCellularComponent	sodium channel complex	SCN11A SCN2A SCN9A	1.46e-04	29	74	3	GO:0034706
GeneOntologyCellularComponent	endoplasmic reticulum membrane	ATXN3L SLC8A3 STIM2 THADA SLC27A1 ATXN3 OSBPL7 CASP4 LRRC8B PLD1 SDR16C5 LRRC8D RYR1 RYR2	1.54e-04	1293	74	14	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	ATXN3L SLC8A3 STIM2 THADA SLC27A1 ATXN3 OSBPL7 CASP4 LRRC8B PLD1 SDR16C5 LRRC8D RYR1 RYR2	1.62e-04	1299	74	14	GO:0098827
GeneOntologyCellularComponent	cation channel complex	CACNA1S SCN11A SCN2A SCN9A RYR1 RYR2	1.85e-04	235	74	6	GO:0034703
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	ATXN3L SLC8A3 STIM2 THADA SLC27A1 ATXN3 OSBPL7 CASP4 LRRC8B PLD1 SDR16C5 LRRC8D RYR1 RYR2	2.02e-04	1327	74	14	GO:0042175
GeneOntologyCellularComponent	transmembrane transporter complex	CACNA1S SCN11A SCN2A SCN9A LRRC8B LRRC8D RYR1 RYR2	5.15e-04	523	74	8	GO:1902495
GeneOntologyCellularComponent	junctional sarcoplasmic reticulum membrane	RYR1 RYR2	5.46e-04	10	74	2	GO:0014701
GeneOntologyCellularComponent	transporter complex	CACNA1S SCN11A SCN2A SCN9A LRRC8B LRRC8D RYR1 RYR2	7.16e-04	550	74	8	GO:1990351
GeneOntologyCellularComponent	sarcoplasm	CACNA1S SLC8A3 RYR1 RYR2	7.19e-04	114	74	4	GO:0016528
GeneOntologyCellularComponent	calcium channel complex	CACNA1S RYR1 RYR2	2.22e-03	73	74	3	GO:0034704
GeneOntologyCellularComponent	nuclear inclusion body	ATXN3L ATXN3	2.25e-03	20	74	2	GO:0042405
GeneOntologyCellularComponent	T-tubule	CACNA1S SCN2A RYR1	2.78e-03	79	74	3	GO:0030315
Domain	Ion_trans_dom	CACNA1S SCN11A SCN2A SCN9A RYR1 RYR2	4.70e-06	114	71	6	IPR005821
Domain	Ion_trans	CACNA1S SCN11A SCN2A SCN9A RYR1 RYR2	4.70e-06	114	71	6	PF00520
Domain	Na_channel_asu	SCN11A SCN2A SCN9A	6.20e-06	10	71	3	IPR001696
Domain	Na_trans_assoc	SCN11A SCN2A SCN9A	6.20e-06	10	71	3	IPR010526
Domain	Na_trans_assoc	SCN11A SCN2A SCN9A	6.20e-06	10	71	3	PF06512
Domain	Ataxin-3	ATXN3L ATXN3	1.42e-05	2	71	2	IPR033865
Domain	Ryanrecept_TM4-6	RYR1 RYR2	4.26e-05	3	71	2	IPR009460
Domain	RyR	RYR1 RYR2	4.26e-05	3	71	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2	4.26e-05	3	71	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR2	4.26e-05	3	71	2	PF06459
Domain	Ryan_recept	RYR1 RYR2	4.26e-05	3	71	2	IPR013333
Domain	Channel_four-helix_dom	CACNA1S SCN11A SCN2A SCN9A	6.50e-05	57	71	4	IPR027359
Domain	-	CACNA1S SCN11A SCN2A SCN9A	6.50e-05	57	71	4	1.20.120.350
Domain	JOSEPHIN	ATXN3L ATXN3	8.51e-05	4	71	2	PS50957
Domain	Josephin	ATXN3L ATXN3	8.51e-05	4	71	2	IPR006155
Domain	Josephin	ATXN3L ATXN3	8.51e-05	4	71	2	PF02099
Domain	Josephin	ATXN3L ATXN3	8.51e-05	4	71	2	SM01246
Domain	LRRC8_Pannexin-like	LRRC8B LRRC8D	1.41e-04	5	71	2	IPR021040
Domain	Pannexin_like	LRRC8B LRRC8D	1.41e-04	5	71	2	PF12534
Domain	RIH_assoc	RYR1 RYR2	2.12e-04	6	71	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2	2.12e-04	6	71	2	IPR013662
Domain	RIH_dom	RYR1 RYR2	2.12e-04	6	71	2	IPR000699
Domain	Na_trans_cytopl	SCN2A SCN9A	2.12e-04	6	71	2	PF11933
Domain	Ins145_P3_rcpt	RYR1 RYR2	2.12e-04	6	71	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	2.12e-04	6	71	2	IPR015925
Domain	-	RYR1 RYR2	2.12e-04	6	71	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR2	2.12e-04	6	71	2	PF01365
Domain	Ins145_P3_rec	RYR1 RYR2	2.12e-04	6	71	2	PF08709
Domain	Na_trans_cytopl	SCN2A SCN9A	2.12e-04	6	71	2	IPR024583
Domain	Calx_beta	FRAS1 SLC8A3	3.93e-04	8	71	2	SM00237
Domain	Calx_beta	FRAS1 SLC8A3	5.04e-04	9	71	2	IPR003644
Domain	Calx-beta	FRAS1 SLC8A3	5.04e-04	9	71	2	PF03160
Domain	MIR	RYR1 RYR2	6.29e-04	10	71	2	PS50919
Domain	MIR	RYR1 RYR2	6.29e-04	10	71	2	PF02815
Domain	MIR	RYR1 RYR2	6.29e-04	10	71	2	SM00472
Domain	MIR_motif	RYR1 RYR2	6.29e-04	10	71	2	IPR016093
Domain	-	PLEKHH1 ACAP1 FRMD7 OSBPL7 PLD1 DCP1A FARP2	7.02e-04	391	71	7	2.30.29.30
Domain	FERM_M	PLEKHH1 FRMD7 FARP2	7.11e-04	46	71	3	PF00373
Domain	EF-hand-dom_pair	CACNA1S STIM2 GUCA1A SCN9A RYR1 RYR2	7.75e-04	287	71	6	IPR011992
Domain	-	PLEKHH1 FRMD7 FARP2	8.56e-04	49	71	3	1.20.80.10
Domain	FERM_central	PLEKHH1 FRMD7 FARP2	8.56e-04	49	71	3	IPR019748
Domain	FERM_domain	PLEKHH1 FRMD7 FARP2	8.56e-04	49	71	3	IPR000299
Domain	FERM_1	PLEKHH1 FRMD7 FARP2	9.08e-04	50	71	3	PS00660
Domain	FERM_2	PLEKHH1 FRMD7 FARP2	9.08e-04	50	71	3	PS00661
Domain	FERM_3	PLEKHH1 FRMD7 FARP2	9.08e-04	50	71	3	PS50057
Domain	Band_41_domain	PLEKHH1 FRMD7 FARP2	9.08e-04	50	71	3	IPR019749
Domain	B41	PLEKHH1 FRMD7 FARP2	9.08e-04	50	71	3	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	PLEKHH1 FRMD7 FARP2	9.08e-04	50	71	3	IPR014352
Domain	FERM-adjacent	FRMD7 FARP2	1.08e-03	13	71	2	IPR014847
Domain	-	MRC1 IGF2R	1.08e-03	13	71	2	2.10.10.10
Domain	FA	FRMD7 FARP2	1.08e-03	13	71	2	SM01195
Domain	FA	FRMD7 FARP2	1.08e-03	13	71	2	PF08736
Domain	PH_dom-like	PLEKHH1 ACAP1 FRMD7 OSBPL7 PLD1 DCP1A FARP2	1.16e-03	426	71	7	IPR011993
Domain	FN_type2_col-bd	MRC1 IGF2R	1.26e-03	14	71	2	IPR000562
Domain	FN2_2	MRC1 IGF2R	1.26e-03	14	71	2	PS51092
Domain	ATPase_dyneun-rel_AAA	VWA8 DNAH2	1.26e-03	14	71	2	IPR011704
Domain	fn2	MRC1 IGF2R	1.26e-03	14	71	2	PF00040
Domain	FN2_1	MRC1 IGF2R	1.26e-03	14	71	2	PS00023
Domain	FN2	MRC1 IGF2R	1.26e-03	14	71	2	SM00059
Domain	AAA_5	VWA8 DNAH2	1.26e-03	14	71	2	PF07728
Domain	PH	PLEKHH1 ACAP1 OSBPL7 PLD1 FARP2	1.79e-03	229	71	5	PF00169
Domain	UIM	ATXN3L ATXN3	2.10e-03	18	71	2	PF02809
Domain	Ez/rad/moesin-like	FRMD7 FARP2	2.86e-03	21	71	2	IPR000798
Domain	UIM	ATXN3L ATXN3	2.86e-03	21	71	2	SM00726
Domain	UIM	ATXN3L ATXN3	3.73e-03	24	71	2	PS50330
Domain	FERM_CS	FRMD7 FARP2	3.73e-03	24	71	2	IPR019747
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1S RYR1 RYR2	8.58e-06	11	54	3	M47958
Pathway	REACTOME_CARDIAC_CONDUCTION	SCN11A SLC8A3 SCN2A SCN9A RYR1 RYR2	9.84e-06	130	54	6	M27454
Pathway	REACTOME_MUSCLE_CONTRACTION	SCN11A SLC8A3 SCN2A SCN9A RYR1 RYR2	1.20e-04	203	54	6	M5485
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN11A SCN2A SCN9A	2.21e-04	31	54	3	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN11A SCN2A SCN9A	2.44e-04	32	54	3	M27455
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1S SLC8A3 STIM2 RYR1 RYR2	2.73e-04	151	54	5	M39329
Pubmed	Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy.	NEFM CACNA1S RYR1	8.02e-07	9	75	3	23785297
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN11A SCN2A SCN9A	8.02e-07	9	75	3	16382098
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	CACNA1S RYR1 RYR2	1.14e-06	10	75	3	18434328
Pubmed	N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation.	ATXN3L ATXN3	4.59e-06	2	75	2	21653538
Pubmed	Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle.	CACNA1S RYR1	4.59e-06	2	75	2	12954602
Pubmed	The genomic structure and expression of MJD, the Machado-Joseph disease gene.	ATXN3L ATXN3	4.59e-06	2	75	2	11450850
Pubmed	Fluorescence resonance energy transfer (FRET) indicates that association with the type I ryanodine receptor (RyR1) causes reorientation of multiple cytoplasmic domains of the dihydropyridine receptor (DHPR) α(1S) subunit.	CACNA1S RYR1	4.59e-06	2	75	2	23071115
Pubmed	Investigating the genetic susceptibility to exertional heat illness.	CACNA1S RYR1	4.59e-06	2	75	2	32054689
Pubmed	Temperature-dependent, irreversible formation of amyloid fibrils by a soluble human ataxin-3 carrying a moderately expanded polyglutamine stretch (Q36).	ATXN3L ATXN3	4.59e-06	2	75	2	14661975
Pubmed	YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.	ATXN3L ATXN3	4.59e-06	2	75	2	11978767
Pubmed	Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties.	ATXN3L ATXN3	4.59e-06	2	75	2	21060878
Pubmed	Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.	ATXN3L ATXN3	4.59e-06	2	75	2	17488727
Pubmed	Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.	ATXN3L ATXN3	4.59e-06	2	75	2	17764659
Pubmed	The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models.	ATXN3L ATXN3	4.59e-06	2	75	2	28676741
Pubmed	Effects of conformational peptide probe DP4 on bidirectional signaling between DHPR and RyR1 calcium channels in voltage-clamped skeletal muscle fibers.	CACNA1S RYR1	4.59e-06	2	75	2	21575570
Pubmed	Regional and age-dependent changes in ubiquitination in cellular and mouse models of spinocerebellar ataxia type 3.	ATXN3L ATXN3	4.59e-06	2	75	2	37122622
Pubmed	Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways.	ATXN3L ATXN3	4.59e-06	2	75	2	30231063
Pubmed	Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle.	CACNA1S RYR1	4.59e-06	2	75	2	12496092
Pubmed	Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells.	ATXN3L ATXN3	4.59e-06	2	75	2	23955261
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	4.59e-06	2	75	2	17259277
Pubmed	Vulnerability of frontal brain neurons for the toxicity of expanded ataxin-3.	ATXN3L ATXN3	4.59e-06	2	75	2	30576445
Pubmed	Clinical utility gene card for: malignant hyperthermia.	CACNA1S RYR1	4.59e-06	2	75	2	21248738
Pubmed	Exome sequencing reveals novel rare variants in the ryanodine receptor and calcium channel genes in malignant hyperthermia families.	CACNA1S RYR1	4.59e-06	2	75	2	24013571
Pubmed	Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.	ATXN3L ATXN3	4.59e-06	2	75	2	12914917
Pubmed	Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.	ATXN3L ATXN3	4.59e-06	2	75	2	20064935
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	4.59e-06	2	75	2	14722100
Pubmed	A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.	ATXN3L ATXN3	4.59e-06	2	75	2	17632007
Pubmed	Mitochondrial Morphology, Function and Homeostasis Are Impaired by Expression of an N-terminal Calpain Cleavage Fragment of Ataxin-3.	ATXN3L ATXN3	4.59e-06	2	75	2	30364204
Pubmed	Basal and stress-induced Hsp70 are modulated by ataxin-3.	ATXN3L ATXN3	4.59e-06	2	75	2	22777893
Pubmed	Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.	ATXN3L ATXN3	4.59e-06	2	75	2	17626202
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	4.59e-06	2	75	2	26009179
Pubmed	Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.	ATXN3L ATXN3	4.59e-06	2	75	2	22843411
Pubmed	Comparison of pathogenicity prediction tools on missense variants in RYR1 and CACNA1S associated with malignant hyperthermia.	CACNA1S RYR1	4.59e-06	2	75	2	27147545
Pubmed	Analysis of the entire ryanodine receptor type 1 and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) coding regions for variants associated with malignant hyperthermia in Australian families.	CACNA1S RYR1	4.59e-06	2	75	2	25735680
Pubmed	Disease-associated oligodendrocyte signatures are spatiotemporally dysregulated in spinocerebellar ataxia type 3.	ATXN3L ATXN3	4.59e-06	2	75	2	36875652
Pubmed	PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.	ATXN3L ATXN3	4.59e-06	2	75	2	18668148
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	4.59e-06	2	75	2	32899693
Pubmed	Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model.	ATXN3L ATXN3	4.59e-06	2	75	2	34220448
Pubmed	The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease.	ATXN3L ATXN3	4.59e-06	2	75	2	24683430
Pubmed	Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo.	ATXN3L ATXN3	4.59e-06	2	75	2	8640226
Pubmed	Functional expression of transgenic 1sDHPR channels in adult mammalian skeletal muscle fibres.	CACNA1S RYR1	4.59e-06	2	75	2	21262876
Pubmed	A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.	ATXN3L ATXN3	4.59e-06	2	75	2	25301414
Pubmed	Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.	ATXN3L ATXN3	4.59e-06	2	75	2	19666135
Pubmed	Expanded ATXN3 frameshifting events are toxic in Drosophila and mammalian neuron models.	ATXN3L ATXN3	4.59e-06	2	75	2	22337953
Pubmed	The alpha(1S) III-IV loop influences 1,4-dihydropyridine receptor gating but is not directly involved in excitation-contraction coupling interactions with the type 1 ryanodine receptor.	CACNA1S RYR1	4.59e-06	2	75	2	18556650
Pubmed	Distinct Components of Retrograde Ca(V)1.1-RyR1 Coupling Revealed by a Lethal Mutation in RyR1.	CACNA1S RYR1	4.59e-06	2	75	2	26910427
Pubmed	Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death.	ATXN3L ATXN3	4.59e-06	2	75	2	20637808
Pubmed	A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes.	ATXN3L ATXN3	4.59e-06	2	75	2	34716557
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	4.59e-06	2	75	2	30542613
Pubmed	Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.	ATXN3L ATXN3	4.59e-06	2	75	2	23626768
Pubmed	Increasing the number of diagnostic mutations in malignant hyperthermia.	CACNA1S RYR1	4.59e-06	2	75	2	19191329
Pubmed	Polyglutamine-induced neurodegeneration in SCA3 is not mitigated by non-expanded ataxin-3: conclusions from double-transgenic mouse models.	ATXN3L ATXN3	4.59e-06	2	75	2	20079840
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	4.59e-06	2	75	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	4.59e-06	2	75	2	11673493
Pubmed	Morphology and molecular composition of sarcoplasmic reticulum surface junctions in the absence of DHPR and RyR in mouse skeletal muscle.	CACNA1S RYR1	4.59e-06	2	75	2	12023238
Pubmed	Malignant-hyperthermia susceptibility is associated with a mutation of the alpha 1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle.	CACNA1S RYR1	4.59e-06	2	75	2	9199552
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	4.59e-06	2	75	2	11673462
Pubmed	A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.	ATXN3L ATXN3	4.59e-06	2	75	2	25320121
Pubmed	The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina.	ATXN3L ATXN3	4.59e-06	2	75	2	33176149
Pubmed	Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture.	ATXN3L ATXN3	4.59e-06	2	75	2	36010688
Pubmed	Study of subcellular localization and proteolysis of ataxin-3.	ATXN3L ATXN3	4.59e-06	2	75	2	18353661
Pubmed	Painful and painless mutations of SCN9A and SCN11A voltage-gated sodium channels.	SCN11A SCN9A	4.59e-06	2	75	2	32601768
Pubmed	Next-generation Sequencing of RYR1 and CACNA1S in Malignant Hyperthermia and Exertional Heat Illness.	CACNA1S RYR1	4.59e-06	2	75	2	25658027
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	4.59e-06	2	75	2	25370123
Pubmed	Quantitative reduction of RyR1 protein caused by a single-allele frameshift mutation in RYR1 ex36 impairs the strength of adult skeletal muscle fibres.	CACNA1S RYR1	4.59e-06	2	75	2	30689883
Pubmed	Four calcium signaling pathway-related genes were upregulated in microcystic adnexal carcinoma: transcriptome analysis and immunohistochemical validation.	CACNA1S RYR1	4.59e-06	2	75	2	35509066
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	4.59e-06	2	75	2	15033925
Pubmed	Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology.	ATXN3L ATXN3	4.59e-06	2	75	2	23242710
Pubmed	The kidney-renal lymph node-system contributes to cross-tolerance against innocuous circulating antigen.	MRC1 CCR7	4.59e-06	2	75	2	18178808
Pubmed	Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.	ATXN3L ATXN3	4.59e-06	2	75	2	23349684
Pubmed	Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.	ATXN3L ATXN3	4.59e-06	2	75	2	18502140
Pubmed	Ataxin-3 is subject to autolytic cleavage.	ATXN3L ATXN3	4.59e-06	2	75	2	16939621
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	4.59e-06	2	75	2	18618700
Pubmed	Impaired Oligodendrocyte Maturation Is an Early Feature in SCA3 Disease Pathogenesis.	ATXN3L ATXN3	4.59e-06	2	75	2	35042771
Pubmed	Neurodegenerative phosphoprotein signaling landscape in models of SCA3.	ATXN3L ATXN3	4.59e-06	2	75	2	33741019
Pubmed	RYR1 and CACNA1S genetic variants identified with statin-associated muscle symptoms.	CACNA1S RYR1	4.59e-06	2	75	2	30325262
Pubmed	Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.	CACNA1S STIM2 RYR1	6.41e-06	17	75	3	22411552
Pubmed	Defining the membrane proteome of NK cells.	KDM3A ACAP1 IGF2R IPO7 PREP SLC27A1 MARF1 PLD1 ITGA4 LRRC8D NNT DCP1A	7.22e-06	1168	75	12	19946888
Pubmed	Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.	CD5 IPO7 LRRC8B CCR7 LRRC8D	1.02e-05	132	75	5	26439863
Pubmed	Mouse ataxin-3 functional knock-out model.	ATXN3L ATXN3	1.37e-05	3	75	2	20945165
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN9A	1.37e-05	3	75	2	19284629
Pubmed	Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.	ATXN3L ATXN3	1.37e-05	3	75	2	25143392
Pubmed	Bayesian modeling to predict malignant hyperthermia susceptibility and pathogenicity of RYR1, CACNA1S and STAC3 variants.	CACNA1S RYR1	1.37e-05	3	75	2	31559918
Pubmed	Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).	ATXN3L ATXN3	1.37e-05	3	75	2	23100324
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	1.37e-05	3	75	2	18403125
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	1.37e-05	3	75	2	18434746
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	1.37e-05	3	75	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	1.37e-05	3	75	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	1.37e-05	3	75	2	21881589
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	1.37e-05	3	75	2	24123915
Pubmed	Interaction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling.	CACNA1S RYR1	1.37e-05	3	75	2	16357209
Pubmed	Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.	ATXN3L ATXN3	1.37e-05	3	75	2	15664989
Pubmed	Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease.	ATXN3L ATXN3	1.37e-05	3	75	2	26505994
Pubmed	Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures.	CACNA1S RYR1	1.37e-05	3	75	2	11206130
Pubmed	Malignant Hyperthermia Susceptibility	CACNA1S RYR1	1.37e-05	3	75	2	20301325
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2	1.37e-05	3	75	2	12213830
Pubmed	Genetic analysis of SCA 2 and 3 repeat expansions in essential tremor and atypical Parkinsonism.	ATXN3L ATXN3	1.37e-05	3	75	2	17712857
Pubmed	Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes.	ATXN3L ATXN3	1.37e-05	3	75	2	28854700
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	1.37e-05	3	75	2	23278119
Pubmed	CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1.	ATXN3L ATXN3	1.37e-05	3	75	2	7874163
Cytoband	7q31	LAMB4 GPR85	9.00e-04	27	75	2	7q31
Cytoband	1p22.2	LRRC8B LRRC8D	9.68e-04	28	75	2	1p22.2
Cytoband	17p13.1	ACAP1 DNAH2 ALOXE3	9.77e-04	118	75	3	17p13.1
Cytoband	14q24.1	PLEKHH1 SLC8A3	1.51e-03	35	75	2	14q24.1
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN11A SCN2A SCN9A	2.60e-06	9	58	3	1203
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	3.03e-05	3	58	2	287
GeneFamily	Ataxins\|MJD deubiquinating enzymes	ATXN3L ATXN3	6.04e-05	4	58	2	997
GeneFamily	Volume regulated anion channel subunits	LRRC8B LRRC8D	1.01e-04	5	58	2	1158
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHH1 ACAP1 OSBPL7 PLD1 FARP2	5.13e-04	206	58	5	682
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PLEKHH1 FRMD7 FARP2	5.52e-04	50	58	3	1293
GeneFamily	Beta 3-glycosyltransferases	B3GALT2 RFNG	2.67e-03	24	58	2	426
Coexpression	FAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON	SLC8A3 LMO7 SLC27A1 SCN2A SCN9A RYR2	8.27e-06	166	75	6	M39026
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer\|World / Primary Cells by Cluster	NEFM LMO7 SCN2A GPR85 SCN9A RYR2	1.03e-06	200	74	6	db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21\|World / Primary Cells by Cluster	NEFM LMO7 SCN2A GPR85 SCN9A RYR2	1.03e-06	200	74	6	30a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SCN11A CD5 OSBPL7 CCR7 ITGA4	5.33e-06	151	74	5	d19fc363ba1d7ff77e0adcaacafa4c64e1143f40
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZFAT SCN9A P2RY14 CCR7 ITGA4	7.50e-06	162	74	5	86a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCell	facs-MAT-Fat-3m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 MAB21L3 ITGA4 RYR1 SBNO2	7.96e-06	164	74	5	b81498c3934e0d52bf0329dc745e02966f9d8613
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S MAB21L3 CCR7 DNAJC22 SBNO2	1.00e-05	172	74	5	c5caae0b21e35a2d5dcd898fbfa1ef33f92c019f
ToppCell	facs-Lung-EPCAM-18m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S MAB21L3 CCR7 DNAJC22 SBNO2	1.00e-05	172	74	5	7c085c02b59e24e2a2cd393b5e692f9fb19257fe
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFM ACAP1 CD5 SCN9A TMEM132B	1.06e-05	174	74	5	ecdff386d7f0bc57c170a2c1f4deae5ba7e431b5
ToppCell	10x3'2.3-week_14-16-Lymphocytic_T-T_NK-NK_T_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	B3GALT2 COL4A4 ACAP1 CD5 CCR7	1.12e-05	176	74	5	f0c01fc4f9c17c4d724642d9931731eef2b10258
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEFM PREP TTC29 CCDC168 SDR16C5	1.12e-05	176	74	5	40993c41c1017b53039a337174fc56632b278609
ToppCell	(7)_DC_plasmacytoid\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	ZFAT GUCA1A SCN9A P2RY14 TMEM132B	1.35e-05	183	74	5	2c6475c935b5a90931be6b3c53f1f707cfcd11f4
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 RGS22 SCN2A SCN9A RYR2	1.39e-05	184	74	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 RGS22 SCN2A SCN9A RYR2	1.39e-05	184	74	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 RGS22 SCN2A SCN9A RYR2	1.39e-05	184	74	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	ASK440-Immune-T_cell\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	B3GALT2 ACAP1 CD5 CCR7 ITGA4	1.50e-05	187	74	5	a260c5e0d1442a2ac6329af3eb11193a33bd4671
ToppCell	ASK440-Immune-T_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	B3GALT2 ACAP1 CD5 CCR7 ITGA4	1.58e-05	189	74	5	868a387d19eb02bf41933e786b7d23e920a5d433
ToppCell	356C-Myeloid-Dendritic-cDC2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ACAP1 CD5 P2RY14 CCR7 ITGA4	1.70e-05	192	74	5	a7ccbea7c90c070d279d7ad3f2b5b7c0e3efd890
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	MRC1 SCN9A OSBPL7 P2RY14 ITGA4	1.79e-05	194	74	5	58046894446cb250814252a23f60fdd59c114d77
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	B3GALT2 ACAP1 CD5 CCR7 ITGA4	1.84e-05	195	74	5	068210aa57e733cbcb54a0b20616f0cb2a1ff639
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	B3GALT2 ACAP1 CD5 CCR7 ITGA4	1.84e-05	195	74	5	b765fa52dcfad9069b74fce342d809d10abede39
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL4A4 MAB21L3 LMO7 ALOXE3 USP54	1.93e-05	197	74	5	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_1-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	B3GALT2 ACAP1 CD5 CCR7 ITGA4	1.93e-05	197	74	5	b4f801cd48955463285e0c1bb4fc8ea790c631cb
ToppCell	Mild_COVID-19-T/NK-CD4+_T_1\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	B3GALT2 ACAP1 CD5 CCR7 ITGA4	1.93e-05	197	74	5	98fca0a2e2f66525c5c9d6cdaebcad14b4d53da4
ToppCell	Control-Myeloid-DC2\|Myeloid / Condition, Lineage and Cell class	ACAP1 CD5 SCN9A P2RY14 ITGA4	1.93e-05	197	74	5	e0ee15188ff0d9df3c3b5ea523553ce18d223c33
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_1\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	B3GALT2 ACAP1 CD5 CCR7 ITGA4	1.93e-05	197	74	5	821c1df511cc4a286ddc6fa229059561f6f6bade
ToppCell	390C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MRC1 VPS35L SCN9A CASP4 SGCE	1.93e-05	197	74	5	c84e988c2ad06087aafda9e3b68e9e72fd0e75f1
ToppCell	390C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MRC1 VPS35L SCN9A CASP4 SGCE	1.93e-05	197	74	5	6195f945b3fd6da07907619267d49e96d1044f8f
ToppCell	distal-Hematologic-CD4+_Naive_T-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NEFM ACAP1 CD5 ALOXE3 CCR7	1.98e-05	198	74	5	4db9eff17778ffc3f77c017ff64f55bc1626da24
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6\|World / Primary Cells by Cluster	B3GALT2 NEFM LMO7 SCN2A RYR2	2.02e-05	199	74	5	1b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal\|World / Primary Cells by Cluster	B3GALT2 NEFM LMO7 SCN2A RYR2	2.02e-05	199	74	5	4bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCell	mLN-(5)_Dendritic_cell-(54)_pDC\|mLN / shred on region, Cell_type, and subtype	ZFAT GUCA1A SCN9A P2RY14 TMEM132B	2.02e-05	199	74	5	1e738219784a446ee8b0ddeb408e0050e1929e60
ToppCell	mLN-Dendritic_cell-pDC\|mLN / Region, Cell class and subclass	ZFAT GUCA1A SCN9A P2RY14 TMEM132B	2.02e-05	199	74	5	54f1abb57af7bf8a8b82a38b933f257df3b5d8df
ToppCell	(54)_pDC\|World / shred on Cell_type and subtype	ZFAT GUCA1A SCN9A P2RY14 TMEM132B	2.23e-05	203	74	5	b8ba3e51770ff7b45cd02472f3e63aa4d5816f6f
ToppCell	COVID-19-kidney-Epithelial_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	MRC1 GALNT8 GPR85 CCR7	4.79e-05	120	74	4	e17c85d41c781a29dec7e03a8b0637dccb4346bc
ToppCell	Globus_pallidus-Macroglia-CSF_related-EPENDYMAL-Ependymal_(Ccdc153)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RGS22 TTC29 CLEC1B DNAJC22	7.15e-05	133	74	4	2caaacb4fb4358c5589c81eaf8dffb85f318fb13
ToppCell	Globus_pallidus-Macroglia-CSF_related-EPENDYMAL\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RGS22 TTC29 CLEC1B DNAJC22	7.15e-05	133	74	4	2d0cade52d79c3d0b6f77418103244150e2ea7fb
ToppCell	Globus_pallidus-Macroglia-CSF_related-EPENDYMAL-Ependymal_(Ccdc153)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RGS22 TTC29 CLEC1B DNAJC22	7.15e-05	133	74	4	25ea1d82a0fc9fed191b9dd33f2a35404a665e7d
ToppCell	Globus_pallidus-Macroglia-CSF_related\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RGS22 TTC29 CLEC1B DNAJC22	7.15e-05	133	74	4	51c60b6d5648968783bffbb22c28d9abaf6243d5
ToppCell	Globus_pallidus-Macroglia-CSF_related-EPENDYMAL-Ependymal_(Ccdc153)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RGS22 TTC29 CLEC1B DNAJC22	7.15e-05	133	74	4	a653282bf871dc9eb47fbf1d55b1eb32ae749c04
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEFM FRAS1 CCR7 RYR1	7.36e-05	134	74	4	cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A4 FRAS1 MAB21L3 SCN2A	9.22e-05	142	74	4	5b6b0c611c83b23ef7289854a515b78f6cf84500
ToppCell	3'_v3-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3\|bone_marrow / Manually curated celltypes from each tissue	COL4A4 SCN2A SCN9A CCDC168	1.11e-04	149	74	4	d7f1069f70f3cad6d3700ee2041ed1d4cb7c49ab
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ZFAT P2RY14 ITGA4 TMEM132B	1.14e-04	150	74	4	57f21ad380fd1350a2c25d75ad8c3b763ded53ec
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFM CLEC1B CCR7 SDR16C5	1.29e-04	155	74	4	72a19a9ecfd13f6769c4b447d3ce01a855ec6ec7
ToppCell	droplet-Heart-4Chambers-21m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S LRRC8B CCR7 RYR1	1.32e-04	156	74	4	5d97755db872d51522f6412a93704f3c79a084cd
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 MAB21L3 ITGA4 RYR1	1.32e-04	156	74	4	2ba838bc864c2c1767bcab7bb4d790af96b91387
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FRAS1 FRMD7 CLEC1B RYR2	1.32e-04	156	74	4	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FRAS1 FRMD7 CLEC1B RYR2	1.32e-04	156	74	4	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALT2 ACAP1 CD5 CCR7	1.36e-04	157	74	4	cbb08d5c151f0622123276926a2a15bb7d271e90
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALT2 ACAP1 CD5 CCR7	1.36e-04	157	74	4	16581e2399a211633f870dce326c75ff4b6a5fe6
ToppCell	LAM-Lymphoid-pDC\|LAM / Condition, Lineage and Cell class	ZFAT SCN9A P2RY14 TMEM132B	1.50e-04	161	74	4	bb5b44713e4da4406cdaa79dcf2aa9f97e3cf75a
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THADA CD5 ALOXE3 CCR7	1.53e-04	162	74	4	b877b232f0a879a9058d81ad4730e7846484b7c3
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THADA CD5 ALOXE3 CCR7	1.53e-04	162	74	4	7384a4dd38ed68ca02a72df6deff4d34c9694ce1
ToppCell	droplet-Marrow-nan-21m-Hematologic-erythroid_progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S LMO7 CCR7 RYR1	1.53e-04	162	74	4	d0ffebf5adee8a3ac9b81a4b793184f54010489a
ToppCell	droplet-Bladder-nan-3m-Hematologic-leukocyte\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 CCR7 ITGA4 RYR1	1.57e-04	163	74	4	2f32a9ab0230fdca98ffa7fd59397301d50e4f30
ToppCell	droplet-Bladder-nan-3m-Hematologic\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 CCR7 ITGA4 RYR1	1.57e-04	163	74	4	6c2967dee563295febe2adabf503d095cb911ccf
ToppCell	facs-MAT-Fat-3m-Myeloid-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ITGA4 RYR1 SBNO2	1.61e-04	164	74	4	1250876abd7311f86730e5b9c03c3610cc2ff6d3
ToppCell	facs-MAT-Fat-3m-Myeloid\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ITGA4 RYR1 SBNO2	1.61e-04	164	74	4	fa0d77b648cde5e42b9394e877168c80de238bde
ToppCell	facs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 CCR7 ITGA4 RYR1	1.61e-04	164	74	4	5ca7b69684a8bb12dd0b45e7ad94e30d16ed01ce
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-B_cells-CLP\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMB4 ACAP1 CCR7 ITGA4	1.61e-04	164	74	4	f5cacd7b2329cb0c7c1696eb4d8f89a4bbd9dda1
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	B3GALT2 ACAP1 CD5 CCR7	1.64e-04	165	74	4	567c9f8fe29b5d34c2e39d9a17db54eba51ee559
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	B3GALT2 ACAP1 CD5 CCR7	1.64e-04	165	74	4	cdc05f4a3c2c301f537ae641314875e5ecc16510
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	B3GALT2 ACAP1 CD5 CCR7	1.64e-04	165	74	4	2ebabe6fdbcf8765bcf9d98faf20da783c9d113d
ToppCell	PND14-Immune-Immune_Myeloid-DC-maDC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1S MAB21L3 CCR7 DNAJC22	1.64e-04	165	74	4	1c3709ac9f96ace1f3b28e1f2f15b4a8d65885ca
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	CD5 DNAH2 CCR7 USP54	1.64e-04	165	74	4	9d2bdc42c13c8c2a68889bec8612a1ce56f659fa
ToppCell	droplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1S MAB21L3 IPO7 CCR7	1.64e-04	165	74	4	c39f0479955c4e23921f7a450d3bc251a002200f
ToppCell	PND14-Immune-Immune_Myeloid-DC-maDC-maDC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1S MAB21L3 CCR7 DNAJC22	1.64e-04	165	74	4	fbc7d97e6f30975d35c76a7c97947a34cf5975d2
ToppCell	facs-Heart-RA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ACAP1 CCR7 RYR1	1.68e-04	166	74	4	fc2cf67311c86fda75b35fcd4768b6f6f14c59d0
ToppCell	356C-Myeloid-Dendritic-cDC1\|356C / Donor, Lineage, Cell class and subclass (all cells)	PLEKHH1 B3GALT2 SCN11A P2RY14	1.68e-04	166	74	4	0590e404f45afce90e20f93f90a3def83949c66b
ToppCell	10x5'-Liver-Myeloid_Dendritic-pDC\|Liver / Manually curated celltypes from each tissue	ZFAT SCN9A P2RY14 TMEM132B	1.68e-04	166	74	4	24dfa9f3e0842f9ab8350bf6a52ae0d10f2a0c44
ToppCell	facs-Heart-RA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ACAP1 CCR7 RYR1	1.68e-04	166	74	4	33a6876d06e26176135a73a77c19e634ec53f7ce
ToppCell	droplet-Lung-nan-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S THADA P2RY14 RYR1	1.72e-04	167	74	4	f33cef917fa733adf6d5a9a9e989a4d9fd462a8f
ToppCell	droplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l34\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 LRRC8B CCR7 ITGA4	1.76e-04	168	74	4	84977db9d71e59208727885320cc18d80d064380
ToppCell	droplet-Bladder-nan-24m-Hematologic-granulocyte-monocyte_progenitor\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S CD5 CCR7 RYR1	1.76e-04	168	74	4	c6e0daa790dd5db20dd1ab8c1e7142484976d743
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ACAP1 RGS22 PLD1 ITGA4	1.80e-04	169	74	4	f68195510b91e287fe1507455ca067ece77a3897
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	COL4A4 LMO7 SCN2A ITGA4	1.80e-04	169	74	4	225aec04ba762d4c55885257de03a65b63503fbb
ToppCell	PND10-Immune-Immune_Myeloid-DC-maDC-maDC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1S MAB21L3 GPR85 CCR7	1.80e-04	169	74	4	a83e4078db91ecedee637b28b12ec38640fe45f9
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	COL4A4 LMO7 SCN2A ITGA4	1.80e-04	169	74	4	278960f940b646a788360b1c84d641a8d169896b
ToppCell	PND10-Immune-Immune_Myeloid-DC-maDC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1S MAB21L3 GPR85 CCR7	1.80e-04	169	74	4	f914aa8899fa170a09da31e5fad86de897ea789b
ToppCell	droplet-Fat-Gat-18m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ACAP1 CCR7 RYR1	1.84e-04	170	74	4	5185187ecf26b4c9eaa0c01ad52697ab8d075cc7
ToppCell	droplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S LMO7 CASP4 RYR1	1.84e-04	170	74	4	29deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCell	droplet-Thymus-nan-21m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S LMO7 CASP4 RYR1	1.84e-04	170	74	4	dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Myeloid-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAP1 ZFAT LTN1 CASP4	1.84e-04	170	74	4	f3d5678669dcaed1836014cea543758b7ccc6b46
ToppCell	Immune-dendritic_cell\|World / Lineage, Cell type, age group and donor	ZFAT P2RY14 CCR7 ITGA4	1.88e-04	171	74	4	6a9e2e2d3e1d8cc475bf9765129bc4a32da3b8ea
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MARF1 USP54 RFNG SBNO2	1.88e-04	171	74	4	6a2f88c2a62cb2f69797804e24eb1137a3e148de
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MARF1 USP54 RFNG SBNO2	1.88e-04	171	74	4	9be3554626408bb897d1f1c43b3ab4a92651f2e2
ToppCell	droplet-Thymus-nan-21m-Myeloid-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S LMO7 CASP4 RYR1	1.88e-04	171	74	4	8bed33f61f7d12a1ac4fba33f730d839f5ee7bef
ToppCell	metastatic_Lymph_Node-Myeloid_cells-pDCs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ZFAT GUCA1A SCN9A P2RY14	1.88e-04	171	74	4	1f8e66073088fc1969782e443bf00f8c1877ea91
ToppCell	Children_(3_yrs)-Immune-dendritic_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZFAT P2RY14 CCR7 ITGA4	1.88e-04	171	74	4	6a5ac0f56bd7b4543be103100fb735ca6bc5b8bf
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3_(Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FRMD7 CCDC168 DNAJC22	1.90e-04	67	74	3	e53dfc288c943656a0b064afe593ea2101d75437
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3_(Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FRMD7 CCDC168 DNAJC22	1.90e-04	67	74	3	1841cee311a4b1b802c9e872793435afb730592f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A3 STIM2 P2RY14 RYR1	1.93e-04	172	74	4	3a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCell	facs-Heart-RV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ACAP1 CD5 CCR7	1.93e-04	172	74	4	2dcc9d67d6ecc35940eabbc8ed528f5f884f6976
ToppCell	facs-Heart-RV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ACAP1 CD5 CCR7	1.93e-04	172	74	4	64d2edbd8e2640b76225597883b1a524e6b1dd3b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A3 STIM2 P2RY14 RYR1	1.93e-04	172	74	4	cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCell	facs-Heart-RV-18m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ACAP1 CD5 CCR7	1.93e-04	172	74	4	d061ea21bee179df5a525842e9a48621a8e1461b
ToppCell	facs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1S MAB21L3 CCR7 DNAJC22	1.93e-04	172	74	4	48d0cfc37d1b1ae48ed8f8b2711abeb609d2bb6e
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Lymphocytic-B_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S ACAP1 CCR7 ITGA4	1.97e-04	173	74	4	a693772987f1baee533dd0bd285a3c7b5619a73b
ToppCell	CTRL-Lymphoid-pDC\|Lymphoid / Disease state, Lineage and Cell class	ZFAT SCN9A P2RY14 ANKRD50	2.01e-04	174	74	4	ff4315e9fad198cc323fc987deb8652da137cf98
ToppCell	-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	ACAP1 CD5 CCR7 ITGA4	2.01e-04	174	74	4	ba50cc04fcdee1926d4af4787ac86555ae9632cc
Drug	chloro-m-cresol	CACNA1S RYR1 RYR2	6.28e-07	6	73	3	CID000012008
Drug	NSC114784	CACNA1S RYR1 RYR2	6.28e-07	6	73	3	CID000419425
Drug	monastrol; Up 200; 20uM; MCF7; HG-U133A	CACNA1S FRAS1 OSBPL7 ALOXE3 PLD1 SBNO2 FARP2	3.28e-06	197	73	7	605_UP
Drug	AC1L9REW	THADA NNT	1.01e-05	2	73	2	CID000454118
Drug	FPL 64176	CACNA1S RYR1 RYR2	1.40e-05	15	73	3	CID000003423
Drug	Zonisamide	SCN11A SCN2A SCN9A	2.08e-05	17	73	3	DB00909
Drug	methylcoumarin	CACNA1S RYR1 RYR2	2.49e-05	18	73	3	CID000007092
Drug	2-hydroxycarbazole	RYR1 RYR2	3.04e-05	3	73	2	CID000093551
Drug	cis-diammineplatinum(II	RYR1 RYR2	3.04e-05	3	73	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR2	3.04e-05	3	73	2	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2	3.04e-05	3	73	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR2	3.04e-05	3	73	2	CID000127713
Drug	aminodantrolene	RYR1 RYR2	3.04e-05	3	73	2	CID009570289
Drug	lamotrigine	CACNA1S SCN2A SCN9A RYR1 RYR2	3.59e-05	116	73	5	CID000003878
Drug	Meclocycline sulfosalicylate [73816-42-9]; Down 200; 5.8uM; PC3; HT_HG-U133A	LMO7 PLD1 NNT RYR2 SBNO2 FARP2	3.97e-05	196	73	6	6637_DN
Drug	0179445-0000 [211246-22-9]; Up 200; 1uM; MCF7; HT_HG-U133A	LAMB4 SCN11A OSBPL7 LRRC8B PLD1 RYR2	4.09e-05	197	73	6	4758_UP
Drug	bepridil	CACNA1S SLC8A3 SCN9A RYR1 RYR2	5.33e-05	126	73	5	CID000002351
Drug	PCB74	RYR1 RYR2	6.06e-05	4	73	2	CID000036218
Drug	148504-47-6	RYR1 RYR2	6.06e-05	4	73	2	CID006444275
Drug	SC 38249	RYR1 RYR2	6.06e-05	4	73	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR2	6.06e-05	4	73	2	CID000035682
Drug	flecainide	SCN11A SCN9A RYR1 RYR2	8.03e-05	71	73	4	CID000003355
Drug	Dp-ba	SCN9A FARP2	1.01e-04	5	73	2	CID006440149
Drug	A 68930	RYR1 RYR2	1.01e-04	5	73	2	ctd:C065380
Drug	LOPAC	SCN2A RYR1 RYR2	1.21e-04	30	73	3	CID000062696
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN11A SCN2A SCN9A	1.72e-06	10	73	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN11A SCN2A SCN9A	1.72e-06	10	73	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN11A SCN2A SCN9A	3.15e-06	12	73	3	DOID:0060170 (implicated_via_orthology)
Disease	Malignant hyperthermia, susceptibility to	CACNA1S RYR1	6.04e-06	2	73	2	cv:C5437603
Disease	Malignant hyperthermia	CACNA1S RYR1	6.04e-06	2	73	2	cv:C5779784
Disease	Malignant hyperpyrexia due to anesthesia	CACNA1S RYR1	6.04e-06	2	73	2	C0024591
Disease	malignant hyperthermia (is_implicated_in)	CACNA1S RYR1	1.81e-05	3	73	2	DOID:8545 (is_implicated_in)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	1.81e-05	3	73	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	1.81e-05	3	73	2	DOID:8545 (implicated_via_orthology)
Disease	PAROXYSMAL EXTREME PAIN DISORDER	SCN11A SCN9A	1.81e-05	3	73	2	C1833661
Disease	Primary Erythermalgia	SCN11A SCN9A	1.81e-05	3	73	2	C0014805
Disease	type 1 diabetes mellitus	ACAP1 LMO7 DNAH2 CCR7 ANKRD50 FARP2	3.08e-05	242	73	6	MONDO_0005147
Disease	Machado-Joseph disease (implicated_via_orthology)	ATXN3L ATXN3	3.61e-05	4	73	2	DOID:1440 (implicated_via_orthology)
Disease	Rare disease with malignant hyperthermia	CACNA1S RYR1	3.61e-05	4	73	2	cv:C5681128
Disease	Hereditary Sensory Autonomic Neuropathy, Type 5	SCN11A SCN9A	1.26e-04	7	73	2	C0020075
Disease	Congenital Pain Insensitivity	SCN11A SCN9A	1.26e-04	7	73	2	C0002768
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN2A SCN9A	2.15e-04	9	73	2	C3502809
Disease	Chronic Lymphocytic Leukemia	CD5 ITGA4 FARP2	3.47e-04	55	73	3	C0023434
Disease	Congenital myopathy (disorder)	CACNA1S RYR1	3.92e-04	12	73	2	C0270960
Disease	Infantile Severe Myoclonic Epilepsy	SCN2A SCN9A	4.63e-04	13	73	2	C0751122
Disease	susceptibility to mononucleosis measurement	DNAH2 ANKRD50 RYR2	6.77e-04	69	73	3	EFO_0008403
Disease	anxiety disorder (implicated_via_orthology)	SCN2A SCN9A	1.35e-03	22	73	2	DOID:2030 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	KDM3A ADCYAP1R1 RYR1 RYR2	1.41e-03	195	73	4	DOID:1574 (implicated_via_orthology)
Disease	hair morphology	FRAS1 THADA	2.35e-03	29	73	2	EFO_0005038

Protein segments in the cluster

Peptide	Gene	Start	Entry
QKYSWCCHLEEVFRK	CASP4	331	P49662
YSAAKSWVFGVHFCK	CCR7	116	P32248
HELWERNSYCKKVFV	CD5	351	P06127
CHFFANKYSFWLTTV	COL4A4	1641	P53420
CSRQEKEAWIHAKYV	ACAP1	501	Q15027
FAEWLLDVKHCTQKY	ANKRD50	411	Q9ULJ7
SIWFYDKNDCHRIAK	DCP1A	106	Q9NPI6
KVEEHSWFTCTGAKY	CECR9	156	P0C854
FDVNFKAHLWTYKAF	SDR16C5	146	Q8N3Y7
YDKFIESGRKWFCHV	RFNG	131	Q9Y644
FHSACLYKWFTSSNK	LTN1	1741	O94822
KHLNLKSCVWTFDAY	FRAS1	3426	Q86XX4
NIFWCHKTFTTKYVT	ALOXE3	251	Q9BYJ1
SFICNYKEHWFTVRK	ATXN3	111	P54252
RDACKAFWKTCVEYH	FRMD7	261	Q6ZUT3
AFWKTCVEYHAFFRL	FRMD7	266	Q6ZUT3
SFICNYKQHWFTIRK	ATXN3L	111	Q9H3M9
LSFQDCYSSKFLKHW	ECHS1	106	P30084
ACWVLHYFCEVKFKS	IPO7	476	O95373
MKKIRICHIFTFYSW	LMO7	1	Q8WWI1
TYRCVGIYKHASKWS	KIR3DX1	91	Q9H7L2
DAVCYEKQLHWFAKF	LRRC8B	106	Q6P9F7
FLTYWKHVKACVIFL	MAS1L	211	P35410
TVLFWTCEKYPHFKD	MAB21L3	286	Q8N8X9
TCEKYPHFKDWQVFS	MAB21L3	291	Q8N8X9
RSWKVNRYFAVDFKH	ADCYAP1R1	416	P41586
CSDSKQHFEWLVKYS	PREP	601	P48147
EFVFNHWRVSYSSCK	B3GALT2	361	O43825
KHCFWLTQEFRYLSQ	KDM3A	1271	Q9Y4C1
FRWKCHDIVKSKVFY	CACNA1S	421	Q13698
CSKAAKNRLHIYWDF	GALNT8	571	Q9NY28
EELSSTECHQWYKKF	GUCA1A	11	P43080
IVREFSQAYHWCFSK	MARF1	1196	Q9Y4F3
IVTCGHRWKNIFYIK	ITGA4	141	P13612
HRFYTKRLTFWTCLA	GPR85	126	P60893
HNWKVFKYFAKDCAT	LAMB4	151	A4D0S4
QHCVWFIDSNKVKYS	CCDC168	396	Q8NDH2
CKNFWKICVEYHTFF	FARP2	306	O94887
CFQEWAKLYEFVHSF	DNAJC22	256	Q8N4W6
TCWHEDYNKFRAGIK	DNAH2	451	Q9P225
IFIYWSKSHNFKREE	RYR1	3441	P21817
EVFIYWSKSHNFKRE	RYR2	3401	Q92736
NFWFKYPKTCSKVEH	LRRC8D	181	Q7L1W4
ITFCKAKYWSSNVHE	OSBPL7	671	Q9BZF2
KEKYLNVSRWFCHIQ	EEF1E1	136	O43324
RQKFQWHEAETYCKL	MRC1	1111	P22897
DFLRTFYTHQELWCK	NNT	31	Q13423
HYFEWRTTAACKKDI	IGF2R	151	P11717
FWAETLIFVKYLCKH	THADA	1836	Q6YHU6
HLYVCAAFLIKWRKE	TBC1D22B	441	Q9NU19
ETACKEYKHSFKQTW	TOP2B	201	Q02880
AFAWKYRHKRFAVSE	TMEM132B	921	Q14DG7
TRFWHGKDYCNFVFK	PLD1	641	Q13393
LFWQEVQKYKDLCHS	RGS22	1051	Q8NE09
IRKTCYKIVEHSWFE	SCN9A	1181	Q15858
FWSAHQRFFKYLCIA	SBNO2	536	Q9Y2G9
RKWHKASNYIFVAIF	P2RY14	181	Q15391
ITCDKKFRTQFYIDW	SGCE	256	O43556
KFRTQFYIDWCKISL	SGCE	261	O43556
CFFIAQSYVLVKKWS	SRP68	466	Q9UHB9
FFRHNLTWEESKQYC	CLEC1B	116	Q9P126
YTSFIRHHKDQWFKC	USP27X	381	A6NNY8
CSFVYGTKWEFNRHL	ZFAT	1046	Q9P243
AEVWVEYTCKHFTKR	VPS35L	506	Q7Z3J2
WKVRYDTFIVSCKFS	WDR88	181	Q6ZMY6
KFSASRFWDDCIKYN	SLC27A1	316	Q6PCB7
CWFAYTQNKTSKEHV	STIM2	231	Q9P246
NLRKTCYKIVEHNWF	SCN2A	1196	Q99250
CYKIVEHNWFETFIV	SCN2A	1201	Q99250
HFKIRLAWFEKMTCY	SLC7A13	441	Q8TCU3
HSKVVWCALVGKIFY	PLEKHH1	701	Q9ULM0
SEIKKWFSDHRYRCQ	ZHX2	481	Q9Y6X8
KWVRNHFYERCFKIA	TTC29	156	Q8NA56
RKTCYQIVKHSWFES	SCN11A	1046	Q9UI33
CDKAFYWVLSFTKHM	ZNF355P	161	Q9NSJ1
CKEFSHKNWLVFYKE	VWA8	1231	A3KMH1
KHYSTFFFQTKIRKW	USP54	301	Q70EL1
SCFDYVMHFLTVFWK	SLC8A3	726	P57103
HQAEEWFKCRYAKLT	NEFM	286	P07197