Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentsuper elongation complex

EAF2 AFF3

2.09e-046792GO:0032783
DomainIPT

PLXNA4 PKHD1 REL PLXNA2

3.92e-0627754SM00429
DomainTIG

PLXNA4 PKHD1 REL PLXNA2

6.95e-0631754PF01833
DomainIPT

PLXNA4 PKHD1 REL PLXNA2

7.92e-0632754IPR002909
DomainZF_CCHC_HIVEP

HIVEP3 HIVEP1

1.59e-052752PS51811
DomainDUF3398

DOCK8 DOCK7

2.36e-046752PF11878
DomainDOCK_C/D_N

DOCK8 DOCK7

2.36e-046752IPR021816
DomainTB

LTBP2 FBN3

3.30e-047752PF00683
Domain-

LTBP2 FBN3

4.39e-0487523.90.290.10
DomainPlexin_cytopl

PLXNA4 PLXNA2

5.62e-049752PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA4 PLXNA2

5.62e-049752IPR013548
DomainPlexin

PLXNA4 PLXNA2

5.62e-049752IPR031148
DomainTB

LTBP2 FBN3

5.62e-049752PS51364
DomainTB_dom

LTBP2 FBN3

5.62e-049752IPR017878
DomainIg_E-set

PLXNA4 PKHD1 REL PLXNA2

8.14e-04104754IPR014756
DomainDOCK_C

DOCK8 DOCK7

8.55e-0411752IPR010703
DomainDHR-1_domain

DOCK8 DOCK7

8.55e-0411752IPR027007
DomainDHR_2

DOCK8 DOCK7

8.55e-0411752PS51651
DomainDHR_1

DOCK8 DOCK7

8.55e-0411752PS51650
DomainDOCK-C2

DOCK8 DOCK7

8.55e-0411752PF14429
DomainDHR-2

DOCK8 DOCK7

8.55e-0411752IPR027357
DomainDHR-2

DOCK8 DOCK7

8.55e-0411752PF06920
DomainDOCK

DOCK8 DOCK7

8.55e-0411752IPR026791
Domain-

IL31RA TRIO PLXNA4 PKHD1 REL LRRC4B LRRC4C HCFC1 PLXNA2

1.32e-036637592.60.40.10
DomainIg-like_fold

IL31RA TRIO PLXNA4 PKHD1 REL LRRC4B LRRC4C HCFC1 PLXNA2

2.03e-03706759IPR013783
Domain-

RNF19A PHF11 BARD1 RIMS1 NEURL1B KAT6B MDM4

2.15e-034497573.30.40.10
DomainZnf_RING/FYVE/PHD

RNF19A PHF11 BARD1 RIMS1 NEURL1B KAT6B MDM4

2.43e-03459757IPR013083
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CEP350 RAPGEF6 AMER1 HIVEP1 OFD1 TRIO SEC16A DOCK7 ANKRD17 ITPRID2 CCDC6 MDM4 TRAK1 FAM110B

9.72e-09861801436931259
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

CEP350 RAPGEF6 OFD1 TRIO SEC16A DOCK7 CCDC6 TRAK1

2.97e-0820980836779422
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

RAPGEF6 HIVEP1 ARID4B SEC16A SENP6 KIAA1958 ANKRD17 RIMS1 ITPRID2 GPATCH8 CCDC6 KAT6B

2.05e-07774801215302935
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PCNX2 HIVEP3 THADA AMER1 TRIO AFF3 BARD1 ANKRD17 RIMS1 ZSWIM1 MBD5 KAT6B LARP4 MDM4 SCARA3

1.34e-061489801528611215
Pubmed

Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.

ANKRD17 IRAK3 OC90 FAM110B

2.01e-063980424556642
Pubmed

NGL-3 in the regulation of brain development, Akt/GSK3b signaling, long-term depression, and locomotive and cognitive behaviors.

LRRC4B LRRC4C

5.23e-06280231166939
Pubmed

Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products.

HIVEP1 REL

5.23e-0628021727488
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

TRIO SEC16A DOCK7 ANKRD17 SRPK1 ITPRID2

7.49e-0620280633005030
Pubmed

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

RELN PLXNA4 PLXNA2

7.79e-061780311683995
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ZC3H7A HIVEP1 ZGRF1 ZNF180 SEC16A SENP6 ITPRID2 CCDC6 MDM4

8.48e-0658880938580884
Pubmed

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.

AMER1 HIVEP1 OFD1 REL GPATCH8 HCFC1

1.42e-0522680625900982
Pubmed

Structural Basis for Plexin Activation and Regulation.

PLXNA4 PLXNA2

1.57e-05380227397516
Pubmed

Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers.

PLXNA4 PLXNA2

1.57e-05380217296555
Pubmed

Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.

PLXNA4 PLXNA2

1.57e-05380218625214
Pubmed

RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination.

RNF19A BARD1

1.57e-05380234789768
Pubmed

Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination.

PLXNA4 PLXNA2

1.57e-05380222777942
Pubmed

Mispositioned Neurokinin-1 Receptor-Expressing Neurons Underlie Heat Hyperalgesia in Disabled-1 Mutant Mice.

RELN TACR1

1.57e-05380231122949
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

CEP350 OFD1 GCLM ANKRD17 ITPRID2 CDKAL1

2.08e-0524280634011540
Pubmed

Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.

PLXNA4 PLXNA2

3.13e-05480211306810
Pubmed

PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.

PLXNA4 PLXNA2

3.13e-05480225518740
Pubmed

A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.

HIVEP3 TNFRSF1B

3.13e-05480211804591
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCNX2 HIVEP3 THADA RAPGEF6 OFD1 TRIO SEC16A MBD5 SCARA3 HCFC1 TRAK1

4.48e-051105801135748872
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

ARID4B TRIO LRRCC1 NEURL1B PZP HCFC1

5.09e-0528480629459677
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RAPGEF6 HIVEP1 ZGRF1 SEC16A DOCK7 KIAA1958 ANKRD17

5.15e-0541880734709266
Pubmed

Guidance-cue control of horizontal cell morphology, lamination, and synapse formation in the mammalian outer retina.

PLXNA4 PLXNA2

5.20e-05580222593055
Pubmed

Regulation of Cardiac Mast Cell Maturation and Function by the Neurokinin-1 Receptor in the Fibrotic Heart.

TACR1 TNFRSF1B

5.20e-05580231358823
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

RAPGEF6 AMER1 OFD1 DOCK8 SEC16A DOCK7 CCDC6

7.72e-0544680724255178
Pubmed

Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.

PLXNA4 PLXNA2

7.79e-05680228438183
Pubmed

Roles of semaphorin-6B and plexin-A2 in lamina-restricted projection of hippocampal mossy fibers.

PLXNA4 PLXNA2

7.79e-05680220484647
Pubmed

Nbeal2 interacts with Dock7, Sec16a, and Vac14.

SEC16A DOCK7

7.79e-05680229187380
Pubmed

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality.

REL TNFRSF1B

7.79e-05680210077625
Pubmed

Human transcription factor protein interaction networks.

EPC2 EYA4 HIVEP1 ARID4B OFD1 SEC16A ANKRD17 REL GPATCH8 LARP4 ATXN1L HCFC1

1.00e-041429801235140242
Pubmed

Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.

PLXNA4 PLXNA2

1.09e-04780219063725
Pubmed

Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.

PLXNA4 PLXNA2

1.09e-04780219655386
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

CEP350 AMER1 SEC16A DOCK7 ANKRD17 GPATCH8 CCDC6 ADGRG4

1.13e-0463980823443559
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

DOCK7 PKHD1 SENP6 ANKRD17 RIMS1

1.22e-0420880533230847
Pubmed

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

EPC2 ARID4B KAT6B

1.26e-044280316387653
Pubmed

A human MAP kinase interactome.

CEP350 ZC3H7A HIVEP1 ARID4B ANKRD17 ITPRID2 MBD5

1.31e-0448680720936779
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

CEP350 ZC3H7A RAPGEF6 AMER1 EAF2 SEC16A DOCK7 REL CCDC6 TRAK1

1.33e-041038801026673895
Pubmed

The expression of plexins during mouse embryogenesis.

PLXNA4 PLXNA2

1.45e-04880215661641
Pubmed

Integration of opposing semaphorin guidance cues in cortical axons.

PLXNA4 PLXNA2

1.45e-04880222368082
Pubmed

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

THADA REL PTGER4 CDKAL1

1.53e-0411680421102463
Pubmed

Interaction network of human early embryonic transcription factors.

EPC2 EYA4 HIVEP1 ARID4B SEC16A ATXN1L

1.62e-0435180638297188
Pubmed

Semaphorin 6A in Retinal Ganglion Cells Regulates Functional Specialization of the Inner Retina.

PLXNA4 PLXNA2

1.86e-04980238014224
Pubmed

The role of neuropilins in cell signalling.

PLXNA4 PLXNA2

1.86e-04980219909241
Pubmed

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.

OFD1 DOCK8 SEC16A DOCK7

2.04e-0412580429467281
Pubmed

Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.

FOXN2 AMER1 HIVEP1 HCFC1

2.23e-0412880425332235
Pubmed

Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development.

PLXNA4 PLXNA2

2.32e-041080218804103
Pubmed

The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.

ANKRD17 HCFC1

2.32e-041080219815555
Pubmed

An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.

PLXNA4 LRRC4C PLXNA2

2.39e-045280326633812
Pubmed

Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception.

RELN TACR1

2.84e-041180225834049
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

CEP350 ZC3H7A TRIO SEC16A GPATCH8 LARP4 HCFC1 CDKAL1

2.86e-0473380834672954
Pubmed

Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.

PLXNA4 PLXNA2

3.40e-041280225839327
Pubmed

De novo genic mutations among a Chinese autism spectrum disorder cohort.

HIVEP3 RIMS1

3.40e-041280227824329
Pubmed

PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.

PLXNA4 PLXNA2

3.40e-041280231690636
Pubmed

On and off retinal circuit assembly by divergent molecular mechanisms.

PLXNA4 PLXNA2

3.40e-041280224179230
Pubmed

Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.

PLXNA4 PLXNA2

3.40e-041280223991118
Pubmed

NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation.

LRRC4B LRRC4C

3.40e-041280216980967
Pubmed

Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels.

PLXNA4 PLXNA2

3.40e-041280228407732
Pubmed

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.

PLXNA4 PLXNA2

3.40e-041280221270798
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SEC16A DOCK7 LRRC4C GPATCH8 PLXNA2 TRAK1

3.59e-0440780612693553
Pubmed

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

AFF3 DOCK7 REL RIMS1 FAM110B

3.73e-0426580519240061
Pubmed

Functional assembly of accessory optic system circuitry critical for compensatory eye movements.

PLXNA4 PLXNA2

4.01e-041380225959730
Pubmed

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

PLXNA4 PLXNA2

4.01e-041380210520995
Pubmed

Plexin signaling via off-track and rho family GTPases.

PLXNA4 PLXNA2

4.01e-041380211604131
Pubmed

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.

PLXNA4 PLXNA2

4.01e-041380222723296
Pubmed

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

RNF19A HCFC1

4.67e-041480210976766
Pubmed

A midline switch of receptor processing regulates commissural axon guidance in vertebrates.

PLXNA4 PLXNA2

4.67e-041480220159958
Pubmed

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

DOCK8 DOCK7

4.67e-041480212432077
Pubmed

E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes.

BARD1 MDM4

5.38e-041580221965653
Pubmed

Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel.

REL HCFC1

5.38e-041580225472883
Pubmed

In the developing cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes.

PLXNA4 PLXNA2

5.38e-041580236028553
Pubmed

Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.

PLXNA4 PLXNA2

6.14e-041680217356169
Pubmed

Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.

PLXNA4 PLXNA2

6.14e-041680222632726
Pubmed

Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.

PLXNA4 PLXNA2

6.14e-041680218489001
Pubmed

Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.

PTGER4 CDKAL1

6.14e-041680220014019
Pubmed

Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

THADA CDKAL1

6.95e-041780219741467
Pubmed

Semaphorin signaling facilitates cleft formation in the developing salivary gland.

PLXNA4 PLXNA2

6.95e-041780217626059
Pubmed

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

THADA CDKAL1

6.95e-041780219502414
Pubmed

Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.

PCNX2 CDKAL1

6.95e-041780221490949
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

CEP350 EPC2 ARID4B OFD1 SEC16A DOCK7 BARD1

7.20e-0464580725281560
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

RELN LTBP2 HCFC1 PLXNA2

7.27e-0417580428071719
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

EYA4 RAPGEF6 DOCK7 ANKRD17 SRPK1 PZP HCFC1

7.53e-0465080738777146
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

CEP350 ZC3H7A AMER1 OFD1 TRIO GCLM LRRCC1 FAM110B

7.75e-0485380828718761
Pubmed

Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.

THADA CDKAL1

7.81e-041880219324937
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

EPC2 FOXN2 EYA4 ARID4B ANKRD17 REL MDM4 HCFC1

7.99e-0485780825609649
Pubmed

Clinical risk factors, DNA variants, and the development of type 2 diabetes.

THADA CDKAL1

8.71e-041980219020324
Pubmed

Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study.

THADA CDKAL1

8.71e-041980219139842
Pubmed

New gene functions in megakaryopoiesis and platelet formation.

THADA DOCK8 AKAP10

8.79e-048180322139419
Pubmed

Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.

THADA CDKAL1

9.66e-042080220075150
Pubmed

PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

THADA CDKAL1

9.66e-042080219862325
Pubmed

Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.

THADA CDKAL1

9.66e-042080219933996
Pubmed

Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.

OFD1 PKHD1

9.66e-042080217251353
Pubmed

Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.

GCLM PHF11 LARP4 HCFC1 CDKAL1

1.03e-0333280529053956
Pubmed

Genotype score in addition to common risk factors for prediction of type 2 diabetes.

THADA CDKAL1

1.07e-032180219020323
Pubmed

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

THADA CDKAL1

1.07e-032180218591388
Pubmed

Underlying genetic models of inheritance in established type 2 diabetes associations.

THADA CDKAL1

1.07e-032180219602701
Pubmed

SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability.

PLXNA4 PLXNA2

1.07e-032180238062045
Pubmed

Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.

OFD1 PKHD1

1.07e-032180227591083
Pubmed

Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.

THADA CDKAL1

1.17e-032280219794065
InteractionCEP85 interactions

CEP350 ZC3H7A EYA4 OFD1 SEC16A ANKRD17 CCDC6

4.49e-06169797int:CEP85
InteractionYWHAH interactions

CEP350 RAPGEF6 AMER1 HIVEP1 OFD1 TRIO SEC16A DOCK7 ANKRD17 RIMS1 ITPRID2 CCDC6 MDM4 ATXN1L TRAK1 FAM110B

4.75e-0611027916int:YWHAH
Cytoband2q23.1

EPC2 MBD5

4.48e-0568022q23.1
Cytoband1q32.2

SYT14 PLXNA2

1.02e-03278021q32.2
GeneFamilyPlexins

PLXNA4 PLXNA2

2.35e-049472683
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

CEP350 PCNX2 HIVEP3 FOXN2 RAPGEF6 ARID4B OFD1 DOCK8 RNF19A PHF11 SENP6 AKAP10 GPATCH8 TNFRSF1B KAT6B MDM4 PTGER4

2.09e-0614928017M40023
CoexpressionGSE28408_LY6G_POS_VS_NEG_DC_UP

PCNX2 RAPGEF6 OFD1 SENP6 AKAP10 PTGER4 TRAK1

2.43e-06197807M9547
CoexpressionGSE32901_TH1_VS_TH17_NEG_CD4_TCELL_UP

ANKRD17 IRAK3 GPATCH8 ZSWIM1 LARP4 OC90

3.08e-06131806M8922
CoexpressionGSE360_CTRL_VS_B_MALAYI_LOW_DOSE_MAC_DN

HIVEP1 BARD1 AKAP10 GPATCH8 KAT6B HCFC1

3.44e-05200806M5169
CoexpressionGSE40068_BCL6_POS_VS_NEG_CXCR5_POS_TFH_DN

ADGB THADA RAPGEF6 AMER1 TRIO SENP6

3.44e-05200806M9260
CoexpressionGSE40068_CXCR5POS_BCL6POS_TFH_VS_CXCR5NEG_BCL6NEG_CD4_TCELL_UP

AMER1 ARID4B TRIO SENP6 IRAK3 ATXN1L

3.44e-05200806M9258
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

CEP350 HIVEP1 TRIO BARD1 ANKRD17 AKAP10 GPATCH8 CCDC6 KAT6B LARP4 TRAK1

5.67e-058568011M4500
CoexpressionAtlasdev gonad_e11.5_F_GonMes_Sma_top-relative-expression-ranked_1000

EPC2 CSRNP1 AMER1 HIVEP1 RNF19A AFF3 PLXNA4 REL ST6GAL1 LRRC4C KAT6B PTGER4 PLXNA2

1.01e-058587613gudmap_dev gonad_e11.5_F_GonMes_Sma_1000
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000

EAF2 OFD1 GCLM ZGRF1 PHF11 SYT14 BARD1 REL GPATCH8 TAF4B LARP4 HCFC1

3.24e-058207612gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlasMyeloid Cells, DC.IIhilang+103-11b+.SLN, MHCIIhi CD11c+ Langerin+ CD103- CD11b+, Lymph Node, avg-3

CEP350 HIVEP1 TRIO RNF19A DOCK7 REL TNFRSF1B PTGER4

1.10e-04411768GSM538271_500
CoexpressionAtlasMyeloid Cells, DC.IIhilang-103-11b+.SLN, MHCIIhi CD11c+ Langerin- CD103- CD11b+, Lymph Node, avg-3

HIVEP1 RNF19A DOCK7 IRAK3 REL ITPRID2 TNFRSF1B PTGER4

1.10e-04411768GSM538274_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_1000

CEP350 EYA4 TRIO KIAA1958 AKAP10 GPATCH8 PLXNA2

1.27e-04312767gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k2
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

EYA4 PLXNA4 LRRC4B LTBP2 TACR1 SCARA3

5.14e-07164806e3983f655cdba308fb192182829f17bef99ce0ba
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF180 PHF11 PLXNA4 BARD1 PTGER4 CDKAL1

7.28e-071748067be0c6248e77f2d0260b852b01e17892f7828f1b
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZNF180 PHF11 PLXNA4 BARD1 PTGER4 CDKAL1

7.52e-071758061b910c08d2bfbcc77431ee66103e63a11a9d39fe
ToppCellCOPD-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

HIVEP1 TRIO AFF3 ST6GAL1 TRAK1 PARP15

1.21e-061908061e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCellcontrol-Lymphocytic-B_cells_1|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

EAF2 TRIO AFF3 REL TRAK1 PARP15

1.41e-06195806ff7956624b36df34e55295b295a71585accf07bd
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-B_lymphocytic-memory_B_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

AFF3 ST6GAL1 MDM4 TRAK1 PARP15

8.88e-06155805d336559092563b0d7776eef873f1d2759aca45f7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM266 IRAK3 LRRC4B PZP PARP15

1.47e-051728053a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM266 IRAK3 LRRC4B PZP PARP15

1.47e-05172805cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

FOXN2 ARID4B TRIO AFF3 CCDC6

1.51e-05173805d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell3'-Adult-SmallIntestine-Hematopoietic-B_cells-Memory_B|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK8 AFF3 REL ST6GAL1 TAF4B

1.69e-051778050d1c39e99144fdb9c7f6f98a1ade41c73db45b65
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLXNA4 LTBP2 RIMS1 TMEM132B SCARA3

1.78e-0517980502c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCellCOPD-Myeloid-pDC|Myeloid / Disease state, Lineage and Cell class

HIVEP3 HIVEP1 OFD1 AFF3 PLXNA4

1.78e-0517980529b058c5e33fda9f0d738c074bdb67ff16b9b6d5
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

EYA4 PLXNA4 LTBP2 SCARA3 TMPRSS11A

1.83e-0518080501f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HIVEP1 AFF3 REL TAF4B PARP15

1.88e-05181805d66838fca0429cad2079cd8d92a5cd33eb0d3522
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

EYA4 TRIO PLXNA4 LTBP2 SCARA3

1.93e-05182805ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLXNA4 LTBP2 RIMS1 TMEM132B SCARA3

1.98e-051838057eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLXNA4 LRRC4B RIMS1 TMEM132B SCARA3

1.98e-0518380512daaea821e49bc94a01e2496331e92a80d27339
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HIVEP1 AFF3 REL TAF4B PARP15

2.09e-05185805e913c64f9b4873443d88dce270f0b7b6d1b4cbce
ToppCellControl-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

ZC3H7A THADA RAPGEF6 HIVEP1 CDKAL1

2.09e-05185805e481cacda0b6b25f5f0062b962df9a442053ac30
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLXNA4 RIMS1 PZP TMEM132B SCARA3

2.09e-05185805e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCellCOVID-19-lung-B_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

EAF2 DOCK8 AFF3 ST6GAL1 PARP15

2.09e-05185805e8f1ad580f19705b5ca1d7d8867b2125f4891684
ToppCellBL-critical-LOC-Lymphoid-B_cell|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EAF2 AFF3 ST6GAL1 LRRC4C PARP15

2.14e-0518680527d4c38b180e4ce2bf3e7c4ad3db3a2ffca05ca8
ToppCellControl-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

TRIO AFF3 ST6GAL1 TRAK1 PARP15

2.20e-051878054e64be635f445276e71f2937f33f041c3a4204ab
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EYA4 DOCK7 ST6GAL1 TRAK1 FAM110B

2.20e-051878052d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCellIPF-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

TRIO AFF3 ST6GAL1 TRAK1 PARP15

2.20e-05187805af1327559f7e01bec070881cae52834917c3da65
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFF3 REL ST6GAL1 MDM4 PARP15

2.25e-05188805d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EYA4 DOCK7 ST6GAL1 FBN3 FAM110B

2.25e-0518880558ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRIO PKHD1 LRRC4C SCARA3 CDKAL1

2.25e-0518880563a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

EYA4 PLXNA4 LTBP2 RIMS1 PLXNA2

2.25e-051888053004e961d214919e08c7cd5f10c3de5cf85b35a3
ToppCellSmart-seq2-spleen_(Smart-seq2)|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CSRNP1 AFF3 REL ST6GAL1 PARP15

2.31e-05189805b0244a9d1b5c8ad4708750b691184f3491b13900
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

EAF2 TRIO AFF3 ST6GAL1 TRAK1

2.31e-05189805886dceacf96e2b6750c146a381da0bf96a2bb15b
ToppCellCTRL-Lymphoid-B_cell|Lymphoid / Disease state, Lineage and Cell class

TRIO AFF3 ST6GAL1 TRAK1 PARP15

2.31e-0518980514f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

EAF2 TRIO AFF3 ST6GAL1 TRAK1

2.31e-051898055f1f4321939877374a8ee13de93f2d1390af8e2e
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZC3H7A THADA RNF19A CCDC6 PTGER4

2.37e-0519080591ba66d4b56c59523485b17738e93f14bb00afa4
ToppCellFetal_29-31_weeks-Immune-B_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

AFF3 REL ST6GAL1 TRAK1 PARP15

2.37e-05190805424550418c1bd4eb070cf3c41cf09fa9d89aef37
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFF3 REL ST6GAL1 MDM4 PARP15

2.49e-05192805446c61c0d6ba89c619efe87ee495951299953981
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CSRNP1 EYA4 PLXNA4 LTBP2 TACR1

2.49e-051928057ae3e1ca8bfc078c0e12a1595ecb0e343dab5d2f
ToppCellB_cells-Memory_B_cells|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

DOCK8 AFF3 REL ST6GAL1 PARP15

2.49e-05192805eef591095921ede098f41a2b81897b18915bb753
ToppCellmoderate-Lymphoid-B_cell|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

EAF2 AFF3 REL ST6GAL1 PARP15

2.49e-05192805ae3727503c3b9f4695e565fd3161cc33b898f349
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

TRIO PKHD1 ANKRD17 MBD5 CDKAL1

2.49e-05192805e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRIO AFF3 REL CCDC6 PARP15

2.55e-0519380508696a99309f5b088692ddac8cca35413b5e810d
ToppCell367C-Myeloid-Dendritic-cDC2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CSRNP1 OFD1 AFF3 REL PTGER4

2.55e-05193805940e9a419d0de1f9e72b5cc9c86684057003be58
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EAF2 AFF3 REL ST6GAL1 PARP15

2.68e-051958050c49d22c348aec6d8a1a976e7c88d0a3b48a4244
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK8 AFF3 IRAK3 REL TNFRSF1B

2.68e-0519580562dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCell11.5-Distal-Mesenchymal-Airway_Smooth_Muscle|Distal / Age, Tissue, Lineage and Cell class

EYA4 PLXNA4 LTBP2 TACR1 PLXNA2

2.75e-0519680505530fe7a5681c2f39b95016cd22ef99d6ac0430
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

EAF2 AFF3 ST6GAL1 TAF4B PARP15

2.75e-05196805e9fe5090452ffdde4bb81b62d57037d823281d00
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_cell-B_mature|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

EAF2 AFF3 ST6GAL1 TAF4B PARP15

2.75e-05196805c2e17f3b2217f20bd7f28a1db4aa7d9a95c52a9c
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

EAF2 AFF3 REL ST6GAL1 PARP15

2.82e-05197805fa3cc33c975648172feabb485c3bdd087f1f8ea7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK8 AFF3 IRAK3 REL TNFRSF1B

2.82e-05197805826cc6baafab13e7ef5cfcf28cd79d0fbf3af38d
ToppCellnormal_Lymph_Node-Myeloid_cells-CD1c+_DCs|Myeloid_cells / Location, Cell class and cell subclass

CSRNP1 AFF3 REL MDM4 PTGER4

2.82e-051978052b3cd318c988364adcba4441444045914d58fe46
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HIVEP3 CSRNP1 IRAK3 ST6GAL1 TACR1

2.89e-0519880592416e65a0dc1a4bf931833407620ea05d362f56
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B|lymph-node_spleen / Manually curated celltypes from each tissue

EAF2 AFF3 REL ST6GAL1 PARP15

2.89e-051988051780fa1725a321041094e8c4430673c0a4f3d407
ToppCellsevere-B_intermediate|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

EAF2 AFF3 REL CCDC6 PARP15

2.96e-0519980517283d75a2a900369f63ed02996e7ede97f46140
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PLXNA4 LTBP2 PZP TMEM132B SCARA3

2.96e-051998056b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-B_lymphocytic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

EAF2 AFF3 REL ST6GAL1 PARP15

2.96e-051998051aa963ed5205d6d52262b1597a5d08707a95c3ca
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

HIVEP3 AFF3 PLXNA4 PLXNA2 FAM110B

3.03e-0520080584e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

HIVEP3 AFF3 PLXNA4 PLXNA2 FAM110B

3.03e-052008051decf1d2cba5ebfd3e5cd4bcd637db8f193033ce
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal|GW23 / Sample Type, Dataset, Time_group, and Cell type.

CSRNP1 WIPI1 DOCK8 TNFRSF1B PTGER4

3.03e-052008050eccf41edefc3b8b5d0316f57d5ba572949aec2b
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

PLXNA4 LTBP2 RIMS1 PZP SCARA3

3.03e-05200805a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CEP350 ARID4B DOCK8 REL MDM4

3.03e-0520080512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4|GI_large-bowel / Manually curated celltypes from each tissue

PCNX2 CSRNP1 RAPGEF6 RNF19A TNFRSF1B

3.03e-0520080542403d59b65d4b3ba6aa4aaf2d7252176067fba5
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

PLXNA4 LRRC4B LTBP2 PZP SCARA3

3.03e-05200805a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCellmild-B_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

EAF2 AFF3 REL MDM4 PARP15

3.03e-05200805222789b897e2a683bbfd1d00b6fd8705015d90df
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

EYA4 CCDC168 TACR1 OC90

7.87e-0512680484dce108561d4b745d19250c2ac0667d9e4ea17d
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse|TCGA-Stomach / Sample_Type by Project: Shred V9

IL31RA AFF3 PZP PARP15

8.62e-051298047d537680b0dfb764f7914d0475c66b678b5cb8d2
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

EYA4 PLXNA4 LTBP2 SCARA3

1.66e-041538041524557514668f515ac1bbe847611f564b265b42
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

RELN RIMS1 LRRC4C TMEM132B

1.93e-041598045335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

AMER1 LRRC4B LTBP2 HCFC1

2.02e-0416180464891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tregs|GI_large-bowel / Manually curated celltypes from each tissue

PCNX2 THADA RNF19A PKHD1

2.07e-041628049a5e65c45f73a6a685b8362aa2e6aea77181caa3
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

FOXN2 TRIO AFF3 CCDC6

2.12e-041638046bed27d2f67a430a847da5eb47878d14b4949c45
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 REL TNFRSF1B PTGER4

2.12e-041638048028636632c168dc50731d0ebecaf88a70daf81d
ToppCell10x5'-bone_marrow-Lymphocytic_B-ABC_aged-B_memory|bone_marrow / Manually curated celltypes from each tissue

AFF3 ST6GAL1 LRRC4C PARP15

2.17e-04164804746833f74095c0f25ce76baf1069f1848c231933
ToppCellAdult-Epithelial-lung_goblet_cell-D175|Adult / Lineage, Cell type, age group and donor

EYA4 TACR1 RIMS1 TMPRSS11A

2.17e-041648046e6aedb61f8e195d52e028fdda750a29bb14e57e
ToppCellfacs-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL31RA DOCK8 REL TNFRSF1B

2.17e-0416480411dfd84f5fb90de330858e1e852848832734e004
ToppCellmetastatic_Brain-Myeloid_cells-pDCs|metastatic_Brain / Location, Cell class and cell subclass

HIVEP1 EAF2 AFF3 PLXNA4

2.17e-0416480406db4cc064f0765c481ce880207823872c27bfa9
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-basal_bladder_epithelial_cell_(Krt5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GCLM PKHD1 KIAA1958 CCDC6

2.22e-04165804936581de8fcd097401707438b9bbe89dd4e3e247
ToppCellnormal_Lymph_Node-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

CSRNP1 RNF19A REL PTGER4

2.27e-04166804d638d356592325cded4a6cb549041cf2f8d3e62c
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF3 PLXNA4 TACR1 GPR101

2.27e-04166804548d0d6c0ffd564036ddba78620734220ebb73d7
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF3 PLXNA4 TACR1 GPR101

2.27e-0416680480e164a89d22098cabe4a99a78283ba69ea0561e
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_AIM2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN EYA4 BARD1 LRRC4C

2.32e-041678044c8bb68ee2bf7b794940b34df96f38f3f69507e9
ToppCellControl-B_cells-Activated_B_cells|Control / group, cell type (main and fine annotations)

DOCK8 AFF3 ST6GAL1 PARP15

2.38e-04168804a7159a35fe37f8c241cf8d391debe271e0698105
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B-ABC_aged-B_naive|lymph-node_spleen / Manually curated celltypes from each tissue

HIVEP3 EAF2 AFF3 PARP15

2.38e-04168804494d5a11154ff22fedb25f4036d730cef376da60
ToppCell368C-Lymphocytic-NK_cells-NK_cell_E|368C / Donor, Lineage, Cell class and subclass (all cells)

OFD1 AFF3 MBD5 CDKAL1

2.43e-041698040d96c0b4fd26fbc0bf44ff7bed2936eebcc55b74
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EYA4 PLXNA4 IRAK3 PTGER4

2.43e-04169804a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

EYA4 AMER1 PLXNA4 TACR1

2.49e-04170804fefb07a7e308b620f946b9ff2b01e1796446fe38
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPC2 AFF3 TAF4B MDM4

2.49e-04170804070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCellnormal-na-Lymphocytic_T-T4_em-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

ARID4B RNF19A KAT6B PTGER4

2.54e-0417180461318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCellCOVID-19-kidney-Bcells|COVID-19 / Disease (COVID-19 only), tissue and cell type

AFF3 REL ST6GAL1 PARP15

2.54e-041718048e8fb79968b1a5c34d1d9cad7f9155fabfdb7cc7
ToppCellfacs-Lung-nan-3m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EAF2 REL ST6GAL1 TMEM132B

2.54e-04171804a31c23406cf6d6a17358a8fb41d392a7fb0306e0
ToppCellfacs-Lung-nan-3m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EAF2 REL ST6GAL1 TMEM132B

2.54e-0417180443d8fd9b9546e84a652564fe96b514b34b06262b
ToppCellMS-CD8-proli_CD4|MS / Condition, Cell_class and T cell subcluster

AMER1 AKAP10 ZSWIM1 TMEM132B

2.60e-041728040b6dd257110b3f17fa71ab18a165b091a9d5ae9a
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

EYA4 LTBP2 SCARA3 TMPRSS11A

2.66e-041738041f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_ASCL1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN EYA4 BARD1 LRRC4C

2.66e-041738042e35bf2b5534a289d93a09faae660f665c131062
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)|356C / Donor, Lineage, Cell class and subclass (all cells)

LTBP2 LRRC4C PZP SCARA3

2.66e-0417380475e26a65071b0d2f30ed0b2aa9859c488f5cf362
ToppCellMild/Remission-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ARID4B AFF3 REL MDM4

2.66e-04173804694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCell356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|356C / Donor, Lineage, Cell class and subclass (all cells)

LTBP2 LRRC4C PZP SCARA3

2.66e-0417380426e2e674f5d312fa8f61c11b553dc6101f063b16
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-plasma_cell-plasma_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN WIPI1 EAF2 ST6GAL1

2.78e-0417580428b29f844fa46fe579ddc19039fb2d9dc5f48f3b
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HIVEP1 TRIO TMEM132B SCARA3

2.78e-04175804dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-plasma_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN WIPI1 EAF2 ST6GAL1

2.78e-04175804ac96ca9ca309b0d72a2f5af6a3b02c7f80755750
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK8 AFF3 REL PARP15

2.84e-04176804274458d80f9f3f080248cbf64e4784ef351e7254
Diseaselevel of Phosphatidylcholine (18:2_18:2) in blood serum

DOCK7 PLXNA4

1.03e-046782OBA_2045106
DiseaseNeurodevelopmental Disorders

HIVEP3 TRIO DOCK8 RIMS1

1.10e-0493784C1535926
Diseasecystitis (implicated_via_orthology)

TACR1 PTGER4

1.91e-048782DOID:1679 (implicated_via_orthology)
Diseasepulse pressure measurement

HIVEP3 EPC2 LTBP2 GPATCH8 NEURL1B CCDC6 GPR101 MBD5 LARP4 HCFC1 CDKAL1 TRAK1

2.81e-0413927812EFO_0005763
Diseasesmoking behavior

SYT14 PLXNA4 PKHD1 LRRC4C TMEM132B PLXNA2

2.91e-04341786EFO_0004318
Diseasesugar consumption measurement

WIPI1 TRIO PKHD1 PLXNA2

2.94e-04120784EFO_0010158
DiseaseDiabetes Mellitus, Non-Insulin-Dependent

EPC2 THADA ST6GAL1 TNFRSF1B CDKAL1

3.05e-04221785C0011860
Diseaseintraocular pressure measurement

HIVEP3 RELN THADA TTC41P AFF3 PKHD1 LTBP2

4.01e-04509787EFO_0004695
Diseasediet measurement

FOXN2 THADA TRIO PKHD1 AKAP10 RIMS1 LRRC4C GPATCH8 MBD5 FAM110B

4.35e-0410497810EFO_0008111
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

HIVEP3 HIVEP1

5.28e-0413782DOID:0050787 (implicated_via_orthology)
Diseaseresponse to ketamine

DOCK8 TMEM266 IRAK3

8.21e-0469783EFO_0009748
DiseaseManic Disorder

RELN TACR1 RIMS1

8.92e-0471783C0024713
DiseaseAlzheimer disease, polygenic risk score

FOXN2 ZNF180 PKHD1 AKAP10 RIMS1 LARP4 SCARA3

9.19e-04586787EFO_0030082, MONDO_0004975
Diseaseosteoporosis (implicated_via_orthology)

IRAK3 PTGER4

1.15e-0319782DOID:11476 (implicated_via_orthology)
Diseasediet measurement, HOMA-B

PCNX2 PLXNA4

1.15e-0319782EFO_0004469, EFO_0008111
Diseaseankylosing spondylitis (is_implicated_in)

TNFRSF1B PTGER4

1.15e-0319782DOID:7147 (is_implicated_in)
DiseaseManic

RELN TACR1 RIMS1

1.17e-0378783C0338831
DiseaseDepression, Bipolar

RELN TACR1 RIMS1

1.22e-0379783C0005587
Diseasedilated cardiomyopathy (implicated_via_orthology)

LTBP2 MDM4 PTGER4

1.26e-0380783DOID:12930 (implicated_via_orthology)
Diseaseselenium measurement, response to dietary selenium supplementation

ZC3H7A TRIO

1.27e-0320782EFO_0006331, EFO_0600021
Diseasecerebellar cortex volume measurement

LRRC4C VSIG10L2

1.40e-0321782EFO_0010291
DiseaseHodgkin Disease

RELN REL

1.54e-0322782C0019829
Diseasealcohol consumption measurement

FOXN2 RELN AFF3 SYT14 PLXNA4 PKHD1 SENP6 KLF18 LRRC4C PLXNA2

1.57e-0312427810EFO_0007878
DiseaseDNA methylation

FOXN2 THADA TRIO PLXNA4 PKHD1 RIMS1 LRRC4C

1.76e-03656787GO_0006306
Diseaseeosinophil count

HIVEP3 THADA RAPGEF6 HIVEP1 PHF11 SEC16A LTBP2 NEURL1B TNFRSF1B MBD5 MDM4

1.80e-0314887811EFO_0004842
Diseaselow density lipoprotein cholesterol measurement, response to escitalopram, response to citalopram

RELN RIMS1

1.83e-0324782EFO_0004611, EFO_0006329, EFO_0007871
Diseasecongestive heart failure (is_implicated_in)

EYA4 TNFRSF1B

2.32e-0327782DOID:6000 (is_implicated_in)
Diseaseretinal degeneration (biomarker_via_orthology)

OFD1 BARD1

2.49e-0328782DOID:8466 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
ATSTSNTLSANHCNM

AFF3

846

P51826
SLCMENSSNSSSDED

ARID4B

851

Q4LE39
SSTSDCMSKTLDSAS

EPC2

621

Q52LR7
SSSASHCSVMNTGQR

BARD1

551

Q99728
TTTNCFSSNTRKMTS

ADGRG4

1786

Q8IZF6
QSLSDCSSAIQTSHM

ADGB

401

Q8N7X0
ISANMDSFSSSRTAT

AKAP10

76

O43572
NSSSSTRSAVDMACS

GCLM

101

P48507
NLFSSMSCSSDSDSS

AMER1

781

Q5JTC6
MSCSSDSDSSFTQNL

AMER1

786

Q5JTC6
NSSSSAAMQSSCSST

CCDC6

16

Q16204
NMRISSCSDESSNSN

ANKRD17

1616

O75179
QTMCRSLSSSSEAVT

FBN3

2306

Q75N90
TFSSMTCASGANVSE

PZP

921

P20742
SCNMETQTSSTFNRD

OFD1

156

O75665
SSSLTQSSCAVTQQM

KAT6B

1711

Q8WYB5
SASITMASFSSEDCS

KIAA1107

1251

Q9UPP5
CQTRQTSATSTTMTV

HCFC1

1166

P51610
SASLNFQSTFSMTTC

PARP15

466

Q460N3
MTSFSTSAQCSTSDS

MDM4

1

O15151
DNCTTNSSTSENRAS

IL31RA

66

Q8NI17
NSCSSDMTDSSTASS

CSRNP1

346

Q96S65
VTSEDMGRTTSCSTN

ATXN1L

21

P0C7T5
CSSQSSEESSRQSCM

ARNTL2

486

Q8WYA1
QMCESNSSKETSLAT

GPATCH8

506

Q9UKJ3
CLSQAREMQVSSSST

PCNX2

736

A6NKB5
LSVVAQTFMDSCSTS

PLXNA2

1771

O75051
LSVVAQTFMDSCSTS

PLXNA4

1771

Q9HCM2
QHCSDSQRTSSAMSG

PTGER4

361

P35408
CMVSNSVGNTTASAT

LRRC4C

426

Q9HCJ2
LEHQSCTINMTSSSS

IRAK3

321

Q9Y616
MTSTCTNSTRESNSS

GPR101

1

Q96P66
TNSTRESNSSHTCMP

GPR101

6

Q96P66
TAAECMTSASFNQSL

OC90

396

Q02509
QAMGSSADSCDSETT

ITPRID2

531

P28290
IGSMSQTDSCNSDLS

RELN

3336

P78509
ASRLSSTSFMSEQSE

RIMS1

1356

Q86UR5
CTESDVSQSQNSRSM

EYA4

16

O95677
DRSCNRMSSHTETSS

DOCK7

956

Q96N67
SSSMDVTRSQACATL

DOCK8

1516

Q8NF50
DQMSSCDSSSDSKSS

EAF2

171

Q96CJ1
HTSAASQCDSASSRM

CDKAL1

531

Q5VV42
TDSSSSDMQACSQDK

CEP350

956

Q5VT06
LSQQRCMNSTSSTED

LTBP2

1561

Q14767
QTECTSAQQLNMSTS

LARP4

531

Q71RC2
QSMSCQSSHLSSNST

MBD5

706

Q9P267
ASMISSDCEQSQDSN

FAM110B

311

Q8TC76
ASSMAAQRCASRSSV

FOXN2

306

P32314
TTSASNQTLCGEQMT

KLF18

281

A0A0U1RQI7
TSTSNQTLCGEQMTT

KLF18

576

A0A0U1RQI7
EQMTTSTSNQTLCGE

KLF18

586

A0A0U1RQI7
TTSASNQTLCGEQMT

KLF18

631

A0A0U1RQI7
GEQMTTSTSNQTLCE

KLF18

641

A0A0U1RQI7
MTTSTSNQTLCGEQT

KLF18

686

A0A0U1RQI7
TTSTSNQTLCGEQMT

KLF18

771

A0A0U1RQI7
TSNQTLCGEQMTTST

KLF18

816

A0A0U1RQI7
FCLSSSTQQELSDTM

CCDC168

3881

Q8NDH2
STTSRQISQEMGSCS

SCARA3

161

Q6AZY7
TTASTNMNASSSRSH

KIF28P

216

B7ZC32
CMVTNSAGNTTASAT

LRRC4B

436

Q9NT99
QQTSSDMVIATCTTT

TAF4B

346

Q92750
DSQMSVSEMSCSEST

SYT14

391

Q8NB59
TVTTAMSQENTCQST

THADA

1751

Q6YHU6
SRSSIVSNCSVDSMS

RAPGEF6

1271

Q8TEU7
IDNGSTQTSATLTCM

TMEM132B

341

Q14DG7
DLTSNCSSRSDSKTM

TACR1

381

P25103
CSSRSDSKTMTESFS

TACR1

386

P25103
MGSDSQSVSSSSTQD

ST6GAL1

56

P15907
ASMETLSASCLVNSS

PKHD1

2541

P08F94
VSDTMVCQSSSTVGQ

SRPK1

421

Q96SB4
CMSQTNSTFTFTTCR

TRAK1

661

Q9UPV9
AESFTNTRESTTTMS

TRAK1

721

Q9UPV9
MCTDKNSIFSTNTSS

RNF19A

101

Q9NV58
SRCSSMSSLSREVSQ

SEC16A

2291

O15027
DSDMTFSVNQSSSAS

NEURL1B

456

A8MQ27
AERLTASSCSMSSQS

HIVEP3

1921

Q5T1R4
SAQSSNTVSSAMCMN

TTC41P

1141

Q6P2S7
SSASEMESCSQNSSA

SENP6

806

Q9GZR1
LSNCSVNMMTTSSDS

REL

491

Q04864
CSFQENRDLMSSSTS

PHF11

311

Q9UIL8
CSETSHSSSLTQNMR

ZNF180

331

Q9UJW8
CSSLNSFSMSESKRD

ZC3H7A

356

Q8IWR0
SESSSSCEELNSEMT

ZGRF1

261

Q86YA3
SDHSSQCSSQASSTM

TNFRSF1B

391

P20333
QCSSQASSTMGDTDS

TNFRSF1B

396

P20333
SMDSQFLCASSNTET

WIPI1

241

Q5MNZ9
TSLQSTMCSATAGNL

ZSWIM1

196

Q9BR11
MCSASNSVNRLSSDG

VSIG10L2

216

P0DP72
CENVFSEMSQNSSLS

HIVEP1

1706

P15822
SSQTLGSSMDCSTAR

TMEM266

401

Q2M3C6
KDTDRMSTCSSASEQ

TRIO

2521

O75962
MSTCSSASEQSVQST

TRIO

2526

O75962
AMSSSTGELTVQASC

TMPRSS11A

161

Q6ZMR5
SLHSSSQTQMVDECS

KIAA1958

181

Q8N8K9
SDAVLTSFMSVCQSS

LRRCC1

266

Q9C099