Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone acetyltransferase activity	NCOA3 KAT6A TAF1 OGA TAF1L	1.53e-06	51	77	5	GO:0004402
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	NCOA3 KAT6A TAF1 OGA TAF1L	2.24e-06	55	77	5	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	NCOA3 KAT6A TAF1 OGA TAF1L	3.46e-06	60	77	5	GO:0034212
GeneOntologyMolecularFunction	N-acetyltransferase activity	NCOA3 KAT6A TAF1 OGA TAF1L	1.27e-05	78	77	5	GO:0008080
GeneOntologyMolecularFunction	N-acyltransferase activity	NCOA3 KAT6A TAF1 OGA TAF1L	4.65e-05	102	77	5	GO:0016410
GeneOntologyMolecularFunction	acetyltransferase activity	NCOA3 KAT6A TAF1 OGA TAF1L	5.10e-05	104	77	5	GO:0016407
GeneOntologyMolecularFunction	basal RNA polymerase II transcription machinery binding	NCOA3 PCIF1 TAF1 TAF1L	1.23e-04	66	77	4	GO:0001099
GeneOntologyMolecularFunction	basal transcription machinery binding	NCOA3 PCIF1 TAF1 TAF1L	1.23e-04	66	77	4	GO:0001098
GeneOntologyMolecularFunction	dATP binding	ST13 HSP90AA1	1.46e-04	5	77	2	GO:0032564
GeneOntologyMolecularFunction	H3K27me3 modified histone binding	TAF1 TAF1L	1.46e-04	5	77	2	GO:0061628
GeneOntologyMolecularFunction	adenyl deoxyribonucleotide binding	ST13 HSP90AA1	2.18e-04	6	77	2	GO:0032558
GeneOntologyMolecularFunction	histone modifying activity	NCOA3 KAT6A TAF1 HUWE1 OGA TAF1L	2.56e-04	229	77	6	GO:0140993
GeneOntologyMolecularFunction	purine deoxyribonucleotide binding	ST13 HSP90AA1	3.04e-04	7	77	2	GO:0032554
GeneOntologyMolecularFunction	disordered domain specific binding	NCOA3 HSP90AA1 HSP90AA2P	4.56e-04	39	77	3	GO:0097718
GeneOntologyMolecularFunction	RNA polymerase I general transcription initiation factor activity	TAF1 TAF1L	5.19e-04	9	77	2	GO:0001181
GeneOntologyMolecularFunction	deoxyribonucleotide binding	ST13 HSP90AA1	5.19e-04	9	77	2	GO:0032552
GeneOntologyMolecularFunction	nitric-oxide synthase regulator activity	AKT1 HSP90AA1	6.47e-04	10	77	2	GO:0030235
GeneOntologyMolecularFunction	ATP hydrolysis activity	KIF21B DNAH12 SMARCAD1 DNAH8 DDX11L8 HSP90AA1 HSP90AA2P	1.55e-03	441	77	7	GO:0016887
GeneOntologyMolecularFunction	chromatin binding	NCOA3 ASXL3 POLE KAT6A SMARCAD1 TAF1 TAF1L BAHD1 DDX11L8	2.11e-03	739	77	9	GO:0003682
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH12 DNAH8	2.16e-03	18	77	2	GO:0008569
GeneOntologyMolecularFunction	RNA methyltransferase activity	NSUN5P1 PCIF1 FTSJ1	2.21e-03	67	77	3	GO:0008173
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	NCOA3 KAT6A TAF1 OGA TAF1L	2.27e-03	238	77	5	GO:0016747
GeneOntologyMolecularFunction	general transcription initiation factor activity	TAF1 TAF1L GTF3C3	2.31e-03	68	77	3	GO:0140223
GeneOntologyMolecularFunction	ATP-dependent activity	KIF21B SETX DNAH12 SMARCAD1 DNAH8 DDX11L8 HSP90AA1 HSP90AA2P	2.49e-03	614	77	8	GO:0140657
GeneOntologyMolecularFunction	microtubule motor activity	KIF21B DNAH12 DNAH8	2.51e-03	70	77	3	GO:0003777
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	KIF21B DNAH12 GBP4 SMARCAD1 RAB20 DNAH8 DDX11L8 HSP90AA1 HSP90AA2P	2.91e-03	775	77	9	GO:0017111
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	NCOA3 ASXL3	2.94e-03	21	77	2	GO:0042975
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	NSUN5P1 SETX POLE PCIF1 PUSL1 FTSJ1 SMARCAD1 DDX11L8	3.37e-03	645	77	8	GO:0140640
GeneOntologyMolecularFunction	S-adenosyl-L-methionine binding	PCIF1 FTSJ1	3.52e-03	23	77	2	GO:1904047
GeneOntologyBiologicalProcess	protein-RNA complex organization	SNRPGP15 SETX CKAP5 TFIP11 SCAF11 SNRPG HSP90AA1	4.96e-05	254	78	7	GO:0071826
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	SNRPGP15 SETX KHDRBS1 PNN CTNNBL1 TFIP11 SCAF11 SNRPG	6.20e-05	358	78	8	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	SNRPGP15 SETX KHDRBS1 PNN CTNNBL1 TFIP11 SCAF11 SNRPG	6.20e-05	358	78	8	GO:0000377
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	SNRPGP15 SETX KHDRBS1 PNN CTNNBL1 TFIP11 SCAF11 SNRPG	6.70e-05	362	78	8	GO:0000375
GeneOntologyCellularComponent	supramolecular fiber	KIF21B CACNA1S DLGAP2 HAUS6 FBN1 DNAH12 PNN NCKIPSD CKAP5 DIAPH1 TMOD4 MAP10 DNAH8 FBN3	1.05e-04	1179	78	14	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	KIF21B CACNA1S DLGAP2 HAUS6 FBN1 DNAH12 PNN NCKIPSD CKAP5 DIAPH1 TMOD4 MAP10 DNAH8 FBN3	1.13e-04	1187	78	14	GO:0099081
GeneOntologyCellularComponent	spindle	HAUS6 FRY CKAP5 DIAPH1 PKHD1 AKT1 MAP10 DDX11L8	3.69e-04	471	78	8	GO:0005819
GeneOntologyCellularComponent	catalytic step 2 spliceosome	SNRPGP15 PNN TFIP11 SNRPG	4.78e-04	97	78	4	GO:0071013
MousePheno	long ribs	CACNA1S FBN1	1.87e-05	2	61	2	MP:0004671
Domain	TAF_II_230-bd	TAF1 TAF1L	1.55e-05	2	74	2	IPR009067
Domain	TFIID_sub1_DUF3591	TAF1 TAF1L	1.55e-05	2	74	2	IPR022591
Domain	-	TAF1 TAF1L	1.55e-05	2	74	2	1.10.1100.10
Domain	TBP-binding	TAF1 TAF1L	1.55e-05	2	74	2	PF09247
Domain	DUF3591	TAF1 TAF1L	1.55e-05	2	74	2	PF12157
Domain	TAF1_animal	TAF1 TAF1L	1.55e-05	2	74	2	IPR011177
Domain	FBN	FBN1 FBN3	4.63e-05	3	74	2	IPR011398
Domain	UIM	STAM2 HUWE1 USP37	1.14e-04	24	74	3	PS50330
Domain	UIM_dom	STAM2 HUWE1 USP37	1.29e-04	25	74	3	IPR003903
Domain	TB	FBN1 FBN3	3.21e-04	7	74	2	PF00683
Domain	-	FBN1 FBN3	4.27e-04	8	74	2	3.90.290.10
Domain	TB	FBN1 FBN3	5.48e-04	9	74	2	PS51364
Domain	TB_dom	FBN1 FBN3	5.48e-04	9	74	2	IPR017878
Domain	WWE	HUWE1 TIPARP	9.96e-04	12	74	2	PS50918
Domain	WWE	HUWE1 TIPARP	9.96e-04	12	74	2	PF02825
Domain	WWE-dom	HUWE1 TIPARP	9.96e-04	12	74	2	IPR004170
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH8	1.37e-03	14	74	2	IPR024317
Domain	Dynein_heavy_dom-2	DNAH12 DNAH8	1.37e-03	14	74	2	IPR013602
Domain	DHC_N2	DNAH12 DNAH8	1.37e-03	14	74	2	PF08393
Domain	AAA_8	DNAH12 DNAH8	1.37e-03	14	74	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH12 DNAH8	1.37e-03	14	74	2	IPR011704
Domain	AAA_5	DNAH12 DNAH8	1.37e-03	14	74	2	PF07728
Domain	DHC_fam	DNAH12 DNAH8	1.57e-03	15	74	2	IPR026983
Domain	Dynein_heavy_dom	DNAH12 DNAH8	1.57e-03	15	74	2	IPR004273
Domain	Dynein_heavy	DNAH12 DNAH8	1.57e-03	15	74	2	PF03028
Domain	ARM-type_fold	AOPEP CKAP5 DIAPH1 CTNNBL1 MROH7 HUWE1	2.25e-03	339	74	6	IPR016024
Domain	UIM	STAM2 USP37	2.27e-03	18	74	2	PF02809
Domain	UIM	STAM2 USP37	3.10e-03	21	74	2	SM00726
Domain	ARM-like	SETX CKAP5 CTNNBL1 MROH7 HUWE1	4.35e-03	270	74	5	IPR011989
Domain	Integrin_dom	ITGA4 ITGB2	4.38e-03	25	74	2	IPR032695
Domain	cEGF	FBN1 FBN3	4.73e-03	26	74	2	IPR026823
Domain	cEGF	FBN1 FBN3	4.73e-03	26	74	2	PF12662
Domain	Bromodomain_CS	TAF1 TAF1L	4.73e-03	26	74	2	IPR018359
Pathway	PID_ILK_PATHWAY	CKAP5 DIAPH1 AKT1 HSP90AA1	4.14e-05	45	61	4	M71
Pathway	WP_CELLS_AND_MOLECULES_INVOLVED_IN_LOCAL_ACUTE_INFLAMMATORY_RESPONSE	C6 ITGA4 ITGB2	5.02e-05	17	61	3	M39733
Pathway	BIOCARTA_LAIR_PATHWAY	C6 ITGA4 ITGB2	5.02e-05	17	61	3	M3952
Pathway	BIOCARTA_P53HYPOXIA_PATHWAY	AKT1 TAF1 HSP90AA1	9.70e-05	21	61	3	M5202
Pubmed	Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase.	AKT1 ST13 HSP90AA1	4.33e-08	4	78	3	21767636
Pubmed	USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID.	USP14 CTNNBL1 AKT1 HSP90AA1	2.40e-07	24	78	4	34983926
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	CENPH CTNNBL1 AKT1 SCFD1 HUWE1 ST13 GTF3C3 HSP90AA1	2.85e-07	288	78	8	23383273
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	FBXO38 CKAP5 CTNNBL1 SCAF11 SMARCAD1 TAF1 HUWE1 HSP90AA1	8.32e-07	332	78	8	32786267
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	USP14 FAM120B SETX PNN POLE CKAP5 DIAPH1 CTNNBL1 TFIP11 SMARCAD1 SCFD1 HUWE1 GTF3C3 HSP90AA1	1.70e-06	1353	78	14	29467282
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	USP14 NCOA3 KHDRBS1 PNN POLE CENPH DIAPH1 CTNNBL1 SMARCAD1 TAF1 GTF3C3 HSP90AA1	2.62e-06	1014	78	12	32416067
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	KHDRBS1 PNN CKAP5 TAF1 TAF1L SNRPG GTF3C3 HSP90AA2P	2.75e-06	390	78	8	17643375
Pubmed	[LFA-1 and VLA-4 involved in vasoendothelial adhesion and transendothelial migration of human high proliferative potential endothelial progenitor cells].	ITGA4 ITGB2	4.97e-06	2	78	2	18549652
Pubmed	Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.	TAF1 TAF1L	4.97e-06	2	78	2	38804708
Pubmed	Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.	TAF1 TAF1L	4.97e-06	2	78	2	22842574
Pubmed	Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity.	TAF1 TAF1L	4.97e-06	2	78	2	27571988
Pubmed	Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.	TAF1 TAF1L	4.97e-06	2	78	2	34403156
Pubmed	Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system.	USP14 AKT1	4.97e-06	2	78	2	26523394
Pubmed	Binding of the pathogen receptor HSP90AA1 to avibirnavirus VP2 induces autophagy by inactivating the AKT-MTOR pathway.	AKT1 HSP90AA1	4.97e-06	2	78	2	25714412
Pubmed	The PI3K and AIB1 interaction is involved in estrogen treated breast cancer cells.	NCOA3 AKT1	4.97e-06	2	78	2	29808803
Pubmed	Integrin-mediated long-term B cell retention in the splenic marginal zone.	ITGA4 ITGB2	4.97e-06	2	78	2	12130787
Pubmed	Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.	FBN1 FBN3	4.97e-06	2	78	2	15221638
Pubmed	Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene.	HSP90AA1 HSP90AA2P	4.97e-06	2	78	2	2591742
Pubmed	Genetic aspects and microenvironment affect expression of CD18 and VLA-4 in experimental tuberculosis.	ITGA4 ITGB2	4.97e-06	2	78	2	12121438
Pubmed	TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin.	TAF1 TAF1L	4.97e-06	2	78	2	10070062
Pubmed	Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis.	AKT1 HSP90AA1	4.97e-06	2	78	2	20585984
Pubmed	NCOA3, a new fusion partner for MOZ/MYST3 in M5 acute myeloid leukemia.	NCOA3 KAT6A	4.97e-06	2	78	2	17805331
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FRY SETX BCORL1 PCIF1 CKAP5 PKHD1 CTNNBL1 C6 HUWE1 FBN3	5.84e-06	736	78	10	29676528
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	SETX KHDRBS1 PNN POLE CKAP5 DIAPH1 SMARCAD1 HUWE1 HSP90AA1	6.33e-06	582	78	9	20467437
Pubmed	New nomenclature for chromatin-modifying enzymes.	NCOA3 KAT6A TAF1 TAF1L	8.45e-06	57	78	4	18022353
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FBXO38 NCOA3 PNN CKAP5 TFIP11 SCAF11 SMARCAD1 SCFD1 HUWE1 OGA	9.05e-06	774	78	10	15302935
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SNRPGP15 SETX KHDRBS1 PNN BCORL1 TFIP11 SCAF11 TAF1 TAF1L SNRPG HSP90AA1	9.09e-06	954	78	11	36373674
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	HAUS6 CKAP5 SMARCAD1 OGA ST13 HSP90AA2P	9.23e-06	215	78	6	35973513
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	NCOA3 STAM2 SETX POLE CTNNBL1 SCAF11 HUWE1 GTF3C3	1.06e-05	469	78	8	27634302
Pubmed	Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.	AKT1 ST13 HSP90AA1	1.20e-05	20	78	3	22504172
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	KHDRBS1 PNN CKAP5 DIAPH1 SCFD1 HUWE1 ST13 GTF3C3 HSP90AA1	1.32e-05	638	78	9	33239621
Pubmed	Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.	AKT1 HSP90AA1	1.49e-05	3	78	2	29139175
Pubmed	Modulation of Akt kinase activity by binding to Hsp90.	AKT1 HSP90AA1	1.49e-05	3	78	2	10995457
Pubmed	The regulatory mechanism of extracellular Hsp90{alpha} on matrix metalloproteinase-2 processing and tumor angiogenesis.	HSP90AA1 HSP90AA2P	1.49e-05	3	78	2	20937816
Pubmed	Alpha4 and beta2 integrins have nonredundant roles for asthma development, but for optimal allergen sensitization only alpha4 is critical.	ITGA4 ITGB2	1.49e-05	3	78	2	17379071
Pubmed	FBXL16 modulates the proliferation and autophagy in breast cancer cells via activating SRC-3-AKT signaling pathway.	NCOA3 AKT1	1.49e-05	3	78	2	34333223
Pubmed	Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation.	AKT1 HSP90AA1	1.49e-05	3	78	2	12586360
Pubmed	Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways.	NCOA3 AKT1	1.49e-05	3	78	2	22213475
Pubmed	Phosphoinositide 3-kinase/AKT signaling can promote AIB1 stability independently of GSK3 phosphorylation.	NCOA3 AKT1	1.49e-05	3	78	2	18593948
Pubmed	Regulated expression of TAF1 in 1-cell mouse embryos.	TAF1 TAF1L	1.49e-05	3	78	2	16822332
Pubmed	Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase.	AKT1 HSP90AA1	1.49e-05	3	78	2	23047954
Pubmed	Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells.	AKT1 HSP90AA1	1.49e-05	3	78	2	19662498
Pubmed	USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1.	USP14 HSP90AA1	1.49e-05	3	78	2	37633951
Pubmed	Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness.	HSP90AA1 HSP90AA2P	1.49e-05	3	78	2	15146192
Pubmed	AIB1 predicts bladder cancer outcome and promotes bladder cancer cell proliferation through AKT and E2F1.	NCOA3 AKT1	1.49e-05	3	78	2	23511556
Pubmed	Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53.	AKT1 HSP90AA1	1.49e-05	3	78	2	19136058
Pubmed	TAFII55 binding to TAFII250 inhibits its acetyltransferase activity.	TAF1 TAF1L	1.49e-05	3	78	2	11592977
Pubmed	Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.	EIF2AK3 HSP90AA1	1.49e-05	3	78	2	12446770
Pubmed	Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis.	TAF1 TAF1L	1.49e-05	3	78	2	12217962
Pubmed	TAF7: a possible transcription initiation check-point regulator.	TAF1 TAF1L	1.49e-05	3	78	2	16407123
Pubmed	HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.	AKT1 HSP90AA1	1.49e-05	3	78	2	29311840
Pubmed	Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation.	ITGA4 ITGB2	2.97e-05	4	78	2	8020569
Pubmed	Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells.	AKT1 HSP90AA1	2.97e-05	4	78	2	11425855
Pubmed	The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha.	HSP90AA1 HSP90AA2P	2.97e-05	4	78	2	19234166
Pubmed	Heat shock protein 90 maintains the tumour-like character of rheumatoid synovial cells by stabilizing integrin-linked kinase, extracellular signal-regulated kinase and protein kinase B.	AKT1 HSP90AA1	2.97e-05	4	78	2	21177334
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN3	2.97e-05	4	78	2	25034023
Pubmed	The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma.	AKT1 HSP90AA1	2.97e-05	4	78	2	23065523
Pubmed	Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14.	HSP90AA1 HSP90AA2P	2.97e-05	4	78	2	1740332
Pubmed	Hop modulates Hsp70/Hsp90 interactions in protein folding.	ST13 HSP90AA1	2.97e-05	4	78	2	9452498
Pubmed	Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis.	AKT1 HSP90AA1	2.97e-05	4	78	2	15782121
Pubmed	Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase.	HSP90AA1 HSP90AA2P	2.97e-05	4	78	2	23589305
Pubmed	Specific phosphorylations transmit signals from leukocyte β2 to β1 integrins and regulate adhesion.	ITGA4 ITGB2	2.97e-05	4	78	2	25278023
Pubmed	EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex.	EPHB3 AKT1	2.97e-05	4	78	2	22314363
Pubmed	Chemokine stimulation of lymphocyte alpha 4 integrin avidity but not of leukocyte function-associated antigen-1 avidity to endothelial ligands under shear flow requires cholesterol membrane rafts.	ITGA4 ITGB2	2.97e-05	4	78	2	12163503
Pubmed	A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links.	FAM120B SETX	2.97e-05	4	78	2	29968717
Pubmed	Unique and redundant roles of alpha4 and beta2 integrins in kinetics of recruitment of lymphoid vs myeloid cell subsets to the inflamed peritoneum revealed by studies of genetically deficient mice.	ITGA4 ITGB2	2.97e-05	4	78	2	17553614
Pubmed	Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.	EPHB3 HUWE1	2.97e-05	4	78	2	27184401
Pubmed	Increased expression of cell adhesion molecules in inflammatory myopathies: diagnostic utility and pathogenetic insights.	ITGA4 ITGB2	2.97e-05	4	78	2	19353432
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	USP14 STAM2 HAUS6 PNN TFIP11 TAF1 HUWE1 GTF3C3	3.26e-05	549	78	8	38280479
Pubmed	The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.	PNN TAF1 USP37 GTF3C3	3.94e-05	84	78	4	26299517
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	USP14 TFIP11 SCAF11 TAF1 TAF1L ST13	4.33e-05	283	78	6	30585729
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	NCOA3 HAUS6 BCORL1 CKAP5 TAF1 HUWE1 GTF3C3	4.37e-05	418	78	7	34709266
Pubmed	RGS10 restricts upregulation by chemokines of T cell adhesion mediated by α4β1 and αLβ2 integrins.	ITGA4 ITGB2	4.94e-05	5	78	2	21705617
Pubmed	IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells.	AKT1 HSP90AA1	4.94e-05	5	78	2	15843522
Pubmed	DIP/WISH-deficient mice reveal Dia- and N-WASP-interacting protein as a regulator of cytoskeletal dynamics in embryonic fibroblasts.	NCKIPSD DIAPH1	4.94e-05	5	78	2	19778379
Pubmed	Adhesion molecules involved in macrophage responses to Wallerian degeneration in the murine peripheral nervous system.	ITGA4 ITGB2	4.94e-05	5	78	2	9421166
Pubmed	The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.	AKT1 HSP90AA1	4.94e-05	5	78	2	18566586
Pubmed	Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo.	AKT1 HSP90AA1	4.94e-05	5	78	2	24126057
Pubmed	Characterization of plasminogen as an adhesive ligand for integrins alphaMbeta2 (Mac-1) and alpha5beta1 (VLA-5).	ITGA4 ITGB2	4.94e-05	5	78	2	15090462
Pubmed	CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions.	ITGA4 ITGB2	4.94e-05	5	78	2	24006483
Pubmed	Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.	KAT6A AKT1	4.94e-05	5	78	2	29021135
Pubmed	The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion.	ITGA4 ITGB2	4.94e-05	5	78	2	12171996
Pubmed	Regulation of human myoblast differentiation by PEBP4.	AKT1 PEBP4	4.94e-05	5	78	2	19197339
Pubmed	Akt and CHIP coregulate tau degradation through coordinated interactions.	AKT1 HSP90AA1	4.94e-05	5	78	2	18292230
Pubmed	Both ICAM-1- and VCAM-1-integrin interactions are important in mediating monocyte adhesion to human saphenous vein.	ITGA4 ITGB2	4.94e-05	5	78	2	12097820
Pubmed	Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation.	AKT1 HSP90AA1	4.94e-05	5	78	2	16844778
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	STAM2 SETX CENPH BCORL1 DIAPH1 SMARCAD1 HUWE1 ST13	5.28e-05	588	78	8	38580884
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	HAUS6 PPP2R3A SETX FRMD6 SCFD1 HUWE1 SLC39A14 GTF3C3 HSP90AA1	6.10e-05	777	78	9	35844135
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	NCOA3 KHDRBS1 CKAP5 CTNNBL1 AKT1 HUWE1 USP37 ST13 GTF3C3 HSP90AA1	6.21e-05	971	78	10	33306668
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	KIF21B STAM2 FAM120B CENPH PCIF1 HUWE1 USP37 GTF3C3	6.37e-05	604	78	8	38803224
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	FBXO38 SETX KAT6A BCORL1 SCAF11 SMARCAD1 TAF1 GTF3C3	6.67e-05	608	78	8	36089195
Pubmed	Mapping the Genetic Landscape of Human Cells.	PNN POLE CKAP5 CTNNBL1 TAF1 SNRPG GTF3C3	7.04e-05	451	78	7	30033366
Pubmed	Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes.	ST13 HSP90AA1	7.40e-05	6	78	2	17324930
Pubmed	Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.	AKT1 HSP90AA1	7.40e-05	6	78	2	12176997
Pubmed	Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.	TAF1 TAF1L	7.40e-05	6	78	2	19959467
Pubmed	Threonine phosphorylation sites in the beta 2 and beta 7 leukocyte integrin polypeptides.	ITGA4 ITGB2	7.40e-05	6	78	2	12682249
Pubmed	MOZ increases p53 acetylation and premature senescence through its complex formation with PML.	KAT6A AKT1	7.40e-05	6	78	2	23431171
Pubmed	The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein.	ST13 HSP90AA1	7.40e-05	6	78	2	26414348
Pubmed	Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect.	AKT1 HSP90AA1	1.04e-04	7	78	2	19356729
Pubmed	The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins.	ITGA4 ITGB2	1.04e-04	7	78	2	9765275
Interaction	SNRNP200 interactions	USP14 KHDRBS1 KAT6A CTNNBL1 TFIP11 HUWE1 ITGA4 USP37 SNRPG GTF3C3 HSP90AA1 TIPARP	1.93e-07	460	78	12	int:SNRNP200
Interaction	TOP1 interactions	USP14 KHDRBS1 PNN ASXL3 POLE KAT6A CKAP5 DIAPH1 CTNNBL1 SCAF11 ITGA4 SNRPG GTF3C3 TIPARP	3.99e-07	696	78	14	int:TOP1
Interaction	PELO interactions	USP14 PNN CKAP5 CTNNBL1 HUWE1 ITGA4 TIPARP	2.99e-06	161	78	7	int:PELO
Interaction	PRPF19 interactions	PNN KAT6A PKHD1 CTNNBL1 TFIP11 SMARCAD1 HUWE1 USP37 SNRPG HSP90AA1	9.04e-06	450	78	10	int:PRPF19
Interaction	SNW1 interactions	KHDRBS1 PNN POLE CKAP5 DIAPH1 CTNNBL1 TFIP11 SMARCAD1 HUWE1 SNRPG HSP90AA1 TIPARP	2.83e-05	747	78	12	int:SNW1
Interaction	SNRNP40 interactions	USP14 SETX KHDRBS1 PNN KAT6A CTNNBL1 TFIP11 SCAF11 SMARCAD1 USP37 SNRPG	3.28e-05	637	78	11	int:SNRNP40
Interaction	U2AF2 interactions	USP14 KHDRBS1 PNN CTNNBL1 TFIP11 SCAF11 SMARCAD1 HUWE1 SNRPG ST13 HSP90AA1	4.00e-05	651	78	11	int:U2AF2
Interaction	SNRPC interactions	SNRPGP15 KHDRBS1 PNN NCKIPSD CTNNBL1 TFIP11 SCAF11 SNRPG TIPARP	5.00e-05	440	78	9	int:SNRPC
Interaction	SF3A3 interactions	USP14 STAM2 PNN KAT6A CTNNBL1 TFIP11 HUWE1 SNRPG	5.08e-05	340	78	8	int:SF3A3
Interaction	XRCC6 interactions	USP14 ASXL3 DIAPH1 TFIP11 SCAF11 SMARCAD1 TAF1 HUWE1 ITGA4 TAF1L ST13 HSP90AA1 TIPARP	5.27e-05	928	78	13	int:XRCC6
Interaction	SSRP1 interactions	USP14 SETX KHDRBS1 PNN POLE KAT6A SCAF11 SMARCAD1 HUWE1 ITGA4 TIPARP	6.33e-05	685	78	11	int:SSRP1
Interaction	CRNKL1 interactions	PNN CTNNBL1 TFIP11 SNRPG HSP90AA1 TIPARP	6.42e-05	177	78	6	int:CRNKL1
Interaction	CDK1 interactions	USP14 KHDRBS1 ASXL3 POLE KAT6A CKAP5 AKT1 HUWE1 ITGA4 HSP90AA1	9.01e-05	590	78	10	int:CDK1
Interaction	WASL interactions	NCKIPSD DIAPH1 ST13 HSP90AA1 TIPARP	9.11e-05	117	78	5	int:WASL
Interaction	HNRNPK interactions	USP14 KHDRBS1 KAT6A CKAP5 DIAPH1 CTNNBL1 SMARCAD1 HUWE1 ITGA4 SNRPG HSP90AA1 TIPARP	1.01e-04	853	78	12	int:HNRNPK
Interaction	CLK2 interactions	PNN FTSJ1 AKT1 HUWE1 HSP90AA1 TIPARP	1.09e-04	195	78	6	int:CLK2
Interaction	USP7 interactions	FBXO38 USP14 SFRP4 FBN1 KHDRBS1 PNN BCORL1 FTSJ1 TFIP11 SMARCAD1 TAF1 HUWE1 OVCH1 ST13 TIPARP	1.33e-04	1313	78	15	int:USP7
Interaction	OGA interactions	C6 OGA ST13 HSP90AA1 TIPARP	1.44e-04	129	78	5	int:OGA
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	NCOA3 KAT6A TAF1	9.56e-06	17	45	3	486
GeneFamily	Dyneins, axonemal	DNAH12 DNAH8	8.04e-04	17	45	2	536
Coexpression	ZHENG_CORD_BLOOD_C4_PUTATIVE_EARLY_ERYTHROID_COMMITMENT	IKZF2 PNN CTNNBL1 ITGA4 HSP90AA1	1.07e-05	97	78	5	M39213
Coexpression	GSE7764_IL15_NK_CELL_24H_VS_SPLENOCYTE_DN	FBXO38 NCOA3 FRY KAT6A HUWE1 ITGA4	2.90e-05	199	78	6	M5726
Coexpression	GSE22886_IGG_IGA_MEMORY_BCELL_VS_BLOOD_PLASMA_CELL_UP	FBXO38 FRY KAT6A HUWE1 OGA IFNA17	2.90e-05	199	78	6	M4444
Coexpression	GSE5589_UNSTIM_VS_180MIN_LPS_STIM_MACROPHAGE_DN	NCOA3 IKZF2 GBP4 POLE SCAF11 RAB20	2.98e-05	200	78	6	M6601
Coexpression	GSE20366_TREG_VS_NAIVE_CD4_TCELL_DEC205_CONVERSION_UP	STAM2 GBP4 FRMD6 AOPEP CENPH RAB20	2.98e-05	200	78	6	M4332
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	HAUS6 SETX PNN POLE CENPH BCORL1 CKAP5 SCAF11 SMARCAD1 USP37	1.53e-05	532	74	10	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_MandArch_2500_K1	EPHB3 HAUS6 SETX PNN ASXL3 POLE CENPH CKAP5 TMOD4 SCAF11 SMARCAD1 KCNAB3 SNRPG HSP90AA1 TIPARP	2.04e-05	1241	74	15	facebase_RNAseq_e10.5_MandArch_2500_K1
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder mesenchyme_emap-3087_top-relative-expression-ranked_1000	HAUS6 FRY SETX GBP4 KHDRBS1 PNN SLC38A4 ASXL3 RDH10 ADGRF5 ITGA4 USP37	3.01e-05	837	74	12	gudmap_developingLowerUrinaryTract_e13.5_bladder mesenchyme_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_MandArch_2500	EPHB3 HAUS6 SETX PNN ASXL3 POLE CENPH CKAP5 TMOD4 SCAF11 SMARCAD1 ITGA4 KCNAB3 SNRPG HSP90AA1 TIPARP	3.67e-05	1468	74	16	facebase_RNAseq_e10.5_MandArch_2500
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	NCOA3 FRY SETX KAT6A NCKIPSD ADGRF5 ITGA4	6.25e-08	200	78	7	abf4ba5fcb54cdeada0da1a8b956a30aa47679e4
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	NCOA3 SFRP4 FBN1 BCORL1 CTNNBL1 ST13	7.15e-07	178	78	6	edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	FBXO38 STAM2 SETX SCAF11 TAF1 USP37	9.24e-07	186	78	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	KIF21B SFRP4 KAT6A ADGRF5 USP37 ITGB2	1.33e-06	198	78	6	af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCell	TCGA-Skin-Metastatic\|TCGA-Skin / Sample_Type by Project: Shred V9	KIF21B SFRP4 KAT6A ADGRF5 USP37 ITGB2	1.33e-06	198	78	6	ad39cce004867f083f8da1954e0cf5a263815184
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	KIF21B SFRP4 KAT6A ADGRF5 USP37 ITGB2	1.33e-06	198	78	6	62cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NCOA3 FRY SETX KAT6A ADGRF5 ITGA4	1.41e-06	200	78	6	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	KIF21B IKZF2 SETX GBP4 DIAPH1 HUWE1	1.41e-06	200	78	6	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	368C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FRY POLE ADGRF5 KCNAB3 PEBP4	8.09e-06	156	78	5	4877aabf647238c0279e497345b6a6d5ee07ef9c
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SFRP4 FBN1 RDH10 SLC39A14 DNAH8	8.09e-06	156	78	5	bb505f639dbcad2b788db62d6084c2cb4e884bec
ToppCell	368C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FRY POLE ADGRF5 KCNAB3 PEBP4	8.09e-06	156	78	5	1d681fa17e62815f5d5f90c86be3c248b38e011b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 GBP4 FRMD6 BCORL1 ADGRF5	1.09e-05	166	78	5	9d4b44eb56ad38c26aed73444edf389abca6bdf6
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETX KAT6A DIAPH1 SCAF11 ITGA4	1.80e-05	184	78	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FRY IKZF2 PKHD1 ADGRF5 FBN3	1.99e-05	188	78	5	0d86044bc340e3efb90d0022dd299873639d831c
ToppCell	10x3'2.3-week_12-13-Lymphocytic_B-B_lineage-pro_B_progenitor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	IKZF2 GBP4 PNN ITGA4 ST13	2.10e-05	190	78	5	f623f0bdece6002b68ac2207e99408b24a2b1194
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	CKAP5 SCAF11 HUWE1 USP37 GTF3C3	2.26e-05	193	78	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FRY SETX KAT6A ADGRF5 ITGA4	2.68e-05	200	78	5	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FRY SETX NCKIPSD ADGRF5 ITGA4	2.68e-05	200	78	5	7034f57e282982c19c13ee8ab78eabaffa069e30
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	NCOA3 SETX KAT6A ADGRF5 ITGA4	2.68e-05	200	78	5	be55cef682ba87250dad97689332c8820b3a7420
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	FRY SETX KAT6A ADGRF5 ITGA4	2.68e-05	200	78	5	432384faeade8e609154fab3d96c955a8ec868dd
Drug	NSC 255110	AKT1 HSP90AA1 HSP90AA2P	9.98e-06	13	76	3	CID000318505
Drug	2qfo	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID000600769
Drug	3-amino-5-chlorobenzoic acid	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID010986726
Drug	3eko	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID011160307
Drug	monocillin III	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID006478910
Drug	pochonin A	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID006478909
Drug	1uyi	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID005289232
Drug	PU-H71	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID009549213
Drug	NSC683666	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID005469153
Drug	H 64	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID006914564
Drug	SureCN4151355	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID015942101
Drug	1uyc	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID000448969
Drug	PU-9	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID000448971
Drug	P u 0	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID000448974
Drug	2qf6	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID013373715
Drug	CHEBI:42139	HSP90AA1 HSP90AA2P	1.10e-05	2	76	2	CID011562562
Drug	Mfpa	TAF1 TAF1L	3.29e-05	3	76	2	CID003035615
Drug	pochonin D	HSP90AA1 HSP90AA2P	3.29e-05	3	76	2	CID006478913
Drug	azaquinone	HSP90AA1 HSP90AA2P	3.29e-05	3	76	2	CID000099132
Drug	d 1 v	HSP90AA1 HSP90AA2P	3.29e-05	3	76	2	CID000683940
Drug	HM-9	HSP90AA1 HSP90AA2P	3.29e-05	3	76	2	CID000433437
Drug	Glyoxylspermidine	HSP90AA1 HSP90AA2P	3.29e-05	3	76	2	CID000133564
Drug	AC1MD0RC	HSP90AA1 HSP90AA2P	3.29e-05	3	76	2	CID002829073
Drug	CL-387,785	AKT1 HSP90AA1 HSP90AA2P	3.91e-05	20	76	3	CID000002776
Drug	CGP7040	AKT1 HSP90AA1 HSP90AA2P	3.91e-05	20	76	3	CID006436259
Drug	NCI60_002052	AKT1 HSP90AA1 HSP90AA2P	3.91e-05	20	76	3	CID006801032
Drug	wedelolactone	AKT1 HSP90AA1 HSP90AA2P	3.91e-05	20	76	3	CID005281813
Drug	UCS15A	KHDRBS1 HSP90AA1 HSP90AA2P	4.55e-05	21	76	3	CID005311041
Drug	Ab-9	CTNNBL1 HSP90AA1 HSP90AA2P	4.55e-05	21	76	3	CID006540280
Drug	O-Su	AKT1 EIF2AK3 HSP90AA1 HSP90AA2P	4.85e-05	60	76	4	CID000447970
Drug	Sulfacetamide sodic hydrate [6209-17-2]; Down 200; 15.8uM; MCF7; HT_HG-U133A	EPHB3 PPP2R3A BCORL1 DIAPH1 TFIP11 BAHD1	5.00e-05	196	76	6	1695_DN
Drug	Oxamniquine [21738-42-1]; Down 200; 14.4uM; HL60; HT_HG-U133A	FBXO38 NCOA3 STAM2 PCIF1 TFIP11 BAHD1	5.00e-05	196	76	6	2924_DN
Drug	Novobiocin sodium salt [1476-53-5]; Up 200; 6.4uM; MCF7; HT_HG-U133A	SFRP4 BCORL1 MROH7 C6 ITGB2 BAHD1	5.29e-05	198	76	6	4392_UP
Drug	Neriolin	KHDRBS1 AKT1 EIF2AK3	6.03e-05	23	76	3	CID000010057
Drug	cruentaren A	AKT1 HSP90AA1	6.57e-05	4	76	2	ctd:C516694
Drug	uranyl chloride	HSP90AA1 HSP90AA2P	6.57e-05	4	76	2	CID000082259
Drug	methoxyhydroquinone	HSP90AA1 HSP90AA2P	6.57e-05	4	76	2	CID000069988
Drug	11p110	HSP90AA1 HSP90AA2P	6.57e-05	4	76	2	CID002382787
Drug	fenthion	CYP3A7 HSP90AA1 HSP90AA2P	6.88e-05	24	76	3	CID000003346
Drug	vorinostat	NCOA3 KAT6A AKT1 EIF2AK3 ST13 HSP90AA1 HSP90AA2P	8.60e-05	314	76	7	CID000005311
Drug	KNK437	AKT1 HSP90AA1 HSP90AA2P	8.79e-05	26	76	3	CID009859662
Drug	AC1L1G9T	EPHB3 KHDRBS1 AKT1 ITGA4 ITGB2 HSP90AA1 IFNA17 HSP90AA2P	9.77e-05	433	76	8	CID000003591
Drug	1uy7	HSP90AA1 HSP90AA2P	1.09e-04	5	76	2	CID005289227
Drug	2-(2,6-dioxopiperidin-3-yl)phthalimidine	ITGA4 ITGB2	1.09e-04	5	76	2	ctd:C001079
Drug	1uyd	HSP90AA1 HSP90AA2P	1.09e-04	5	76	2	CID000448970
Drug	Org 31806	HSP90AA1 HSP90AA2P	1.09e-04	5	76	2	CID000164147
Drug	CRT0044876	HSP90AA1 HSP90AA2P	1.09e-04	5	76	2	CID000081409
Drug	HCV-796	HSP90AA1 HSP90AA2P	1.09e-04	5	76	2	CID011561383
Drug	chaetochromin	HSP90AA1 HSP90AA2P	1.09e-04	5	76	2	CID000053277
Drug	1,1-diphenyl-2-propyn-1-ol	HSP90AA1 HSP90AA2P	1.09e-04	5	76	2	CID000092976
Drug	4-hydroxyestradiol	CYP3A7 AKT1 HSP90AA1 HSP90AA2P	1.42e-04	79	76	4	CID000001743
Drug	AC1L8SKE	ITGB2 HSP90AA1 HSP90AA2P	1.50e-04	31	76	3	CID000386852
Drug	Hantzsch ester	HSP90AA1 HSP90AA2P	1.64e-04	6	76	2	CID000070849
Drug	3-aminocoumarin	HSP90AA1 HSP90AA2P	1.64e-04	6	76	2	CID000074217
Drug	Pu x	HSP90AA1 HSP90AA2P	1.64e-04	6	76	2	CID000448976
Drug	oxygen anion	AKT1 ITGB2	1.64e-04	6	76	2	CID005460641
Drug	15-deoxyspergualin	C6 HSP90AA1 HSP90AA2P	1.65e-04	32	76	3	CID000055361
Drug	SureCN1562346	STAM2 CYP3A7 CTNNBL1	1.81e-04	33	76	3	CID011646228
Drug	17-aminogeldanamycin	HSP90AA1 HSP90AA2P	2.28e-04	7	76	2	CID000429444
Drug	Nepl	HSP90AA1 HSP90AA2P	2.28e-04	7	76	2	CID006439214
Drug	NSC330499	HSP90AA1 HSP90AA2P	2.28e-04	7	76	2	CID000433447
Drug	1,2,4,7,8-pentachlorodibenzo-p-dioxin	HSP90AA1 HSP90AA2P	2.28e-04	7	76	2	CID000042836
Drug	Zlll-mca	HSP90AA1 HSP90AA2P	2.28e-04	7	76	2	CID000132936
Drug	dienochlor	HSP90AA1 HSP90AA2P	2.28e-04	7	76	2	CID000016686
Drug	geldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A_EA	SETX FTSJ1 SLC39A14 EIF2AK3 GTF3C3	2.36e-04	166	76	5	1066_UP
Drug	geldanamycin; Up 200; 1uM; HL60; HT_HG-U133A	STAM2 PPP2R3A RAB20 OGA GTF3C3	2.43e-04	167	76	5	6187_UP
Drug	eupatilin	AKT1 HSP90AA1 HSP90AA2P	2.77e-04	38	76	3	CID005273755
Drug	Murametide	ITGA4 ITGB2	3.04e-04	8	76	2	CID000133276
Drug	phenyldichloroarsine	HSP90AA1 HSP90AA2P	3.04e-04	8	76	2	CID000012762
Drug	GGMP	HSP90AA1 HSP90AA2P	3.04e-04	8	76	2	CID006443839
Drug	D-box	HSP90AA1 HSP90AA2P	3.04e-04	8	76	2	CID000133881
Drug	9-phenanthrol	HSP90AA1 HSP90AA2P	3.04e-04	8	76	2	CID000010229
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN3	1.96e-05	3	76	2	DOID:65 (implicated_via_orthology)
Disease	cancer (implicated_via_orthology)	FRMD6 POLE AKT1 ITGB2 HSP90AA1 HSP90AA2P	6.82e-05	268	76	6	DOID:162 (implicated_via_orthology)
Disease	urate measurement, bone density	USP14 DLGAP2 GBP4 DIAPH1 SCFD1 DNAH8 TIPARP PEBP4	1.93e-04	619	76	8	EFO_0003923, EFO_0004531
Disease	nephritis (implicated_via_orthology)	ITGA4 ITGB2	2.91e-04	10	76	2	DOID:10952 (implicated_via_orthology)
Disease	pneumonia (implicated_via_orthology)	ITGA4 ITGB2	2.91e-04	10	76	2	DOID:552 (implicated_via_orthology)
Disease	Small cell carcinoma of lung	EPHB3 AKT1 TAF1L	3.71e-04	54	76	3	C0149925
Disease	Mental Retardation, X-Linked Nonsyndromic	FTSJ1 HUWE1	5.01e-04	13	76	2	C3501611
Disease	T-Cell Lymphoma	ASXL3 AKT1	7.67e-04	16	76	2	C0079772
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	PKHD1 AKT1	7.67e-04	16	76	2	DOID:0110861 (implicated_via_orthology)
Disease	Child Behaviour Checklist assessment	NKX2-6 PEBP4	9.75e-04	18	76	2	EFO_0005661
Disease	Adenocarcinoma of large intestine	POLE AKT1 TAF1	1.98e-03	96	76	3	C1319315
Disease	Heart valve disease	C6 ITGB2	2.04e-03	26	76	2	C0018824

Protein segments in the cluster

Peptide	Gene	Start	Entry
MITITPPDQDDSMEC	AKT1	446	P31749
IVENMAEFRPEMCTE	CTNNBL1	221	Q8WYA6
AMDQDEEEQTVLTPM	EIF2AK3	961	Q9NZJ5
QLEREMASPPECSEM	BCORL1	606	Q5H9F3
QDDECIPMMTPSDIT	DLGAP2	581	Q9P1A6
DEMQCSPEEMQVLRP	AOPEP	541	Q8N6M6
QPEDMNERVLEAMTE	DIAPH1	271	O60610
MMTCEDIDECSLNPL	FBN3	2161	Q75N90
QIAPPEDNLESCVMM	ASXL3	491	Q9C0F0
PQEMGDENAEITEEM	ST13	96	P50502
VPCMESIMTEDRLNE	MROH7	1226	Q68CQ1
MLDEQDVPAAEQMCF	RAB20	166	Q9NX57
PCEAVLEMDAERMGE	NKX2-6	76	A6NCS4
MEMETTEPEPDCVVQ	TIPARP	1	Q7Z3E1
QTRPALDMCQEMEQL	C22orf46	181	C9J442
ITIEPQMNAPEEMDD	MAP10	321	Q9P2G4
SQPEEVMDVLEMVEN	PNN	381	Q9H307
LMMVVTGDEDENSPC	PEBP4	16	Q96S96
DMTEAHMPCVQVEAN	FAM205A	1001	Q6ZU69
DNEIQMDMTLGPIEE	DNAH8	1131	Q96JB1
MRMCTQPDLVNEAVT	KIF21B	236	O75037
EPIFCSEDIMQQMPE	DNAH12	916	Q6ZR08
PVMILTEFMENCALD	EPHB3	706	P54753
IMMAPICLVENQEEQ	GBP4	21	Q96PP9
PEDMCRMATEQPQTL	POLE	441	Q07864
SMCSLCQEENEDMVP	NSUN5P1	91	Q3KNT7
MEDCKEQEPIMDNNI	IKZF2	241	Q9UKS7
METDMDGVQCIPQRA	HUWE1	491	Q7Z6Z7
YEEQCERMEAMGIEP	PPP2R3A	1001	Q06190
CIMNNEIPEEMTADE	FBXO38	11	Q6PIJ6
GLDAMMQVAACPEEI	ITGB2	236	P05107
QADEDPQMSMVEDCH	KAT6A	1461	Q92794
EQMNEESLEVSPDMC	FRMD6	466	Q96NE9
AVELMDRTEMPCQAL	CKAP5	626	Q14008
RVKCMANEVMEDPGQ	CEFIP	926	Q711Q0
EANPPFCEELMDAMV	PCIF1	551	Q9H4Z3
MEEQPQMQDADEPAD	CENPH	1	Q9H3R5
MENNGQPCINDDEEM	C6	616	P13671
DACQMEPEEVEIMAT	CACNA1S	1816	Q13698
MMTCEDINECAQNPL	FBN1	2201	P35555
DLPQMMDEVGRILCN	DDX11L8	681	A8MPP1
MVCMDPLVDDNDDIL	C1orf112	141	Q9NSG2
EPLQMEDSNMEQGVE	BAHD1	21	Q8TBE0
SNDENEPETCMVEKM	ITGA4	791	P13612
EMEENRTKEPIQMDA	HAUS6	601	Q7Z4H7
VPDMMDDICQEQFLE	KHDRBS1	256	Q07666
EVPQMEDMILDCELN	IZUMO1	171	Q8IYV9
QPEDDDRPMIDVMDQ	FRY	776	Q5TBA9
MPEETQTQDQPMEEE	HSP90AA1	1	P07900
DCQQPMLAITDPDMI	CYP3A7	76	P24462
EDNNEMIPMECDSFC	SCAF11	711	Q99590
LADMFPEMNEVCQED	SLC39A14	441	Q15043
MPEETQTQDQPMEEE	HSP90AA2P	1	Q14568
ACVIQEVGMEETPLM	IFNA17	121	P01571
VPMCSDAESRQEVPM	FAM120B	341	Q96EK7
SDPNCPMEEIVRAMT	KCNAB3	201	O43448
PADCLDMVAMQEAAQ	PUSL1	156	Q8N0Z8
CEANPDLIFEDMEVM	SMARCAD1	811	Q9H4L7
MQEDCISDIAPMQTD	OGA	516	O60502
PEQCLADDEITMMVP	TAF1L	321	Q8IZX4
PPEQCLSDDEITMMA	TAF1	301	P21675
LQEMELPIMDDRACN	OVCH1	191	Q7RTY7
QPRAMMEEGEDLQSC	NCOA3	231	Q9Y6Q9
NDPEDMDLCSQMEND	SETX	1501	Q7Z333
METEAEMECETPNQP	PKHD1	1886	P08F94
MDPMELRNVNIEPDD	SLC38A4	1	Q969I6
ECPDELIERTMMVNC	RDH10	156	Q8IZV5
LNEEETSPQCQMDRM	NCKIPSD	691	Q9NZQ3
PVDEEMIMLQCTETF	STRA8	311	Q7Z7C7
EEAILMCMEIIRQAP	GTF3C3	166	Q9Y5Q9
EEMKVMCDNNPVSLN	ADGRF5	376	Q8IZF2
PFMNLVIDECVEMAT	SNRPG	36	P62308
TPDMMVQERPLDVDC	SFRP4	156	Q6FHJ7
PFMNLVIDECVEMAT	SNRPGP15	36	A8MWD9
FVMPTEENIDRMCQD	SCFD1	91	Q8WVM8
DLEDICQQMGPMIDE	STAM2	321	O75886
CQQMGPMIDEKLEEI	STAM2	326	O75886
LDCELQEMDPENMLL	TMOD4	31	Q9NZQ9
DAVEMEMATVLEQCP	TMOD4	296	Q9NZQ9
QCHTLLAPEMEDNEM	FTSJ1	311	Q9UET6
AEDDIQEMPENPDTM	USP37	741	Q86T82
DMTEEQLASAMELPC	USP14	91	P54578
MQTEECPPMLDATQQ	SERINC2	351	Q96SA4
VLEMVEECERRMQPD	TFIP11	376	Q9UBB9