Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintegrin binding

VWF ADAM23 TLN2 ADAM11 JAM2

1.54e-04175585GO:0005178
GeneOntologyMolecularFunctionG protein-coupled receptor kinase activity

GRK4 GRK6

1.73e-047582GO:0004703
GeneOntologyBiologicalProcessmedial motor column neuron differentiation

LHX4 LHX3

7.24e-062562GO:0021526
GeneOntologyBiologicalProcessaxon guidance

LHX4 SEMA3B LRP1 LAMB3 LHX3 NOTCH1 EPHA8

1.16e-05285567GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

LHX4 SEMA3B LRP1 LAMB3 LHX3 NOTCH1 EPHA8

1.19e-05286567GO:0097485
GeneOntologyBiologicalProcesspresynaptic actin cytoskeleton organization

PCLO TLN2

7.20e-055562GO:0099140
GeneOntologyBiologicalProcesssomatic motor neuron differentiation

LHX4 LHX3

7.20e-055562GO:0021523
GeneOntologyBiologicalProcesspresynaptic cytoskeleton organization

PCLO TLN2

1.08e-046562GO:0099187
GeneOntologyBiologicalProcesscell-substrate adhesion

VWF TRIP6 PIK3CB LRP1 LAMB3 BCAM NOTCH1

1.17e-04410567GO:0031589
GeneOntologyCellularComponentstriated muscle myosin thick filament

OBSCN MYBPC3

4.52e-054582GO:0005863
GeneOntologyCellularComponentcone cell pedicle

SLC32A1 PCLO

7.53e-055582GO:0044316
GeneOntologyCellularComponentextracellular matrix

VWF LRRC24 SULF1 SEMA3B LAMB3 LOXL4 MUC5B ADAM11 BCAM

7.53e-05656589GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

VWF LRRC24 SULF1 SEMA3B LAMB3 LOXL4 MUC5B ADAM11 BCAM

7.70e-05658589GO:0030312
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex, class I

PIK3CB PIK3R2

2.69e-049582GO:0097651
GeneOntologyCellularComponentphosphatidylinositol 3-kinase complex, class IA

PIK3CB PIK3R2

2.69e-049582GO:0005943
GeneOntologyCellularComponentcoated vesicle

SLC32A1 CPNE6 VWF ERGIC3 LRP1 SEC31B

4.76e-04360586GO:0030135
GeneOntologyCellularComponentcollagen-containing extracellular matrix

VWF SULF1 SEMA3B LAMB3 LOXL4 ADAM11 BCAM

6.36e-04530587GO:0062023
GeneOntologyCellularComponentcell surface

SLC32A1 LIFR HAVCR1 VWF LRRC24 SULF1 LRP1 BCAM NOTCH1 JAM2

8.77e-0411115810GO:0009986
GeneOntologyCellularComponentmyosin filament

OBSCN MYBPC3

2.18e-0325582GO:0032982
GeneOntologyCellularComponentcell-cell contact zone

OBSCN TLN2 JAM2

2.27e-0394583GO:0044291
DomainTalin-1

TLNRD1 TLN2

2.94e-053592IPR015710
DomainEGF-like_CS

ADAM23 LRP1 LAMB3 ADAM11 NOTCH1 EPHA8

1.70e-04261596IPR013032
DomainEGF_2

ADAM23 LRP1 LAMB3 ADAM11 NOTCH1 EPHA8

1.85e-04265596PS01186
DomainGPCR_kinase

GRK4 GRK6

2.04e-047592IPR000239
Domain-

LIFR HAVCR1 LRRC24 SEMA3B OBSCN BCAM JAM2 EPHA8 MYBPC3

2.18e-046635992.60.40.10
DomainIg-like_fold

LIFR HAVCR1 LRRC24 SEMA3B OBSCN BCAM JAM2 EPHA8 MYBPC3

3.46e-04706599IPR013783
DomainIG

HAVCR1 LRRC24 SEMA3B OBSCN BCAM JAM2 MYBPC3

3.49e-04421597SM00409
DomainIg_sub

HAVCR1 LRRC24 SEMA3B OBSCN BCAM JAM2 MYBPC3

3.49e-04421597IPR003599
DomainTIL

VWF MUC5B

6.34e-0412592PF01826
DomainC8

VWF MUC5B

6.34e-0412592PF08742
DomainQuinoprot_gluc/sorb_DH

LRP1 HHIPL1

6.34e-0412592IPR011041
DomainUnchr_dom_Cys-rich

VWF MUC5B

7.48e-0413592IPR014853
DomainC8

VWF MUC5B

7.48e-0413592SM00832
DomainIGc2

LRRC24 OBSCN BCAM JAM2 MYBPC3

8.70e-04235595SM00408
DomainIg_sub2

LRRC24 OBSCN BCAM JAM2 MYBPC3

8.70e-04235595IPR003598
DomainIG_LIKE

HAVCR1 LRRC24 SEMA3B OBSCN BCAM JAM2 MYBPC3

8.70e-04491597PS50835
DomainPP2C_SIG

PPM1J PPTC7

8.71e-0414592SM00331
DomainTIL_dom

VWF MUC5B

8.71e-0414592IPR002919
DomainEGF_extracell

ADAM23 ADAM11 NOTCH1

9.02e-0460593IPR013111
DomainEGF_2

ADAM23 ADAM11 NOTCH1

9.02e-0460593PF07974
DomainIg-like_dom

HAVCR1 LRRC24 SEMA3B OBSCN BCAM JAM2 MYBPC3

1.00e-03503597IPR007110
DomainVWD

VWF MUC5B

1.14e-0316592SM00216
DomainVWF_type-D

VWF MUC5B

1.14e-0316592IPR001846
DomainVWFD

VWF MUC5B

1.14e-0316592PS51233
DomainVWD

VWF MUC5B

1.14e-0316592PF00094
Domain-

PLCD3 CPNE6 PIK3CB PCLO

1.23e-031485942.60.40.150
DomainEGF_1

ADAM23 LRP1 LAMB3 ADAM11 NOTCH1

1.25e-03255595PS00022
DomainLIM

LHX4 TRIP6 LHX3

1.35e-0369593PF00412
Domain-

LHX4 TRIP6 LHX3

1.41e-03705932.10.110.10
DomainCTCK_1

VWF MUC5B

1.45e-0318592PS01185
DomainADAM_CR

ADAM23 ADAM11

1.45e-0318592PF08516
DomainZnf_LIM

LHX4 TRIP6 LHX3

1.47e-0371593IPR001781
DomainLIM_DOMAIN_1

LHX4 TRIP6 LHX3

1.47e-0371593PS00478
DomainLIM_DOMAIN_2

LHX4 TRIP6 LHX3

1.47e-0371593PS50023
DomainLIM

LHX4 TRIP6 LHX3

1.47e-0371593SM00132
DomainVWC_out

VWF MUC5B

1.62e-0319592SM00215
Domainfn3

LIFR OBSCN EPHA8 MYBPC3

1.71e-03162594PF00041
DomainC2_dom

PLCD3 CPNE6 PIK3CB PCLO

1.79e-03164594IPR000008
DomainPP2Cc

PPM1J PPTC7

1.80e-0320592SM00332
DomainPPM-type_phosphatase_dom

PPM1J PPTC7

1.80e-0320592IPR001932
Domain-

ADAM23 ADAM11

1.80e-03205924.10.70.10
Domain-

PPM1J PPTC7

1.80e-03205923.60.40.10
DomainPPM_2

PPM1J PPTC7

1.80e-0320592PS51746
DomainDisintegrin

ADAM23 ADAM11

1.98e-0321592PF00200
DomainSRCR

LOXL4 HHIPL1

1.98e-0321592PF00530
DomainDISIN

ADAM23 ADAM11

1.98e-0321592SM00050
DomainCT

VWF MUC5B

2.18e-0322592SM00041
DomainFN3

LIFR OBSCN EPHA8 MYBPC3

2.77e-03185594SM00060
DomainSR

LOXL4 HHIPL1

2.81e-0325592SM00202
Domain-

LOXL4 HHIPL1

2.81e-03255923.10.250.10
DomainCys_knot_C

VWF MUC5B

2.81e-0325592IPR006207
DomainCTCK_2

VWF MUC5B

2.81e-0325592PS01225
DomainSRCR_1

LOXL4 HHIPL1

3.04e-0326592PS00420
DomainSRCR_2

LOXL4 HHIPL1

3.04e-0326592PS50287
DomainSRCR-like_dom

LOXL4 HHIPL1

3.04e-0326592IPR017448
DomainIg_I-set

LRRC24 OBSCN JAM2 MYBPC3

3.05e-03190594IPR013098
Domainig

SEMA3B OBSCN BCAM JAM2

3.05e-03190594PF00047
DomainImmunoglobulin

SEMA3B OBSCN BCAM JAM2

3.05e-03190594IPR013151
DomainI-set

LRRC24 OBSCN JAM2 MYBPC3

3.05e-03190594PF07679
DomainACR

ADAM23 ADAM11

3.27e-0327592SM00608
DomainADAM_Cys-rich

ADAM23 ADAM11

3.27e-0327592IPR006586
DomainSRCR

LOXL4 HHIPL1

3.27e-0327592IPR001190
DomainVWC

VWF MUC5B

3.52e-0328592PF00093
DomainFN3

LIFR OBSCN EPHA8 MYBPC3

3.60e-03199594PS50853
DomainIg_V-set

HAVCR1 OBSCN BCAM JAM2

3.60e-03199594IPR013106
DomainFN3_dom

LIFR OBSCN EPHA8 MYBPC3

4.29e-03209594IPR003961
DomainRGS

GRK4 GRK6

5.46e-0335592PF00615
DomainRGS

GRK4 GRK6

5.46e-0335592SM00315
DomainVWFC_1

VWF MUC5B

5.77e-0336592PS01208
DomainRGS

GRK4 GRK6

5.77e-0336592PS50132
PathwayREACTOME_SIGNALING_BY_LTK_IN_CANCER

PIK3CB PIK3R2

2.07e-047452M48255
PathwayREACTOME_RET_SIGNALING

NRTN PIK3CB PIK3R2

2.37e-0438453MM15493
PathwayREACTOME_PI3K_AKT_ACTIVATION

PIK3CB PIK3R2

2.76e-048452MM14776
PathwayREACTOME_RET_SIGNALING

NRTN PIK3CB PIK3R2

2.77e-0440453M27746
PathwayREACTOME_PI3K_AKT_ACTIVATION

PIK3CB PIK3R2

3.54e-049452M714
PathwayWP_FOCAL_ADHESION

VWF PIK3CB PIK3R2 LAMB3 TLN2

4.12e-04199455M39402
PathwayKEGG_FOCAL_ADHESION

VWF PIK3CB PIK3R2 LAMB3 TLN2

4.12e-04199455M7253
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PLCD3 TLNRD1 ZNF628 MROH1 LRRC24 GRK6 OBSCN LAMB3 TLN2 BCAM ATP2A3 REXO1 NOTCH1

4.05e-081105601335748872
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

LRRC24 SEMA3B OBSCN LHX3 BCAM JAM2

3.78e-0716260625826454
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

HAVCR1 ADAM23 SEMA3B ADAM11 EPHA8

1.86e-0611760517145500
Pubmed

Molecular cloning and expression analysis of the mouse Spot-2 gene in pituitary development.

LHX4 LHX3

2.93e-06260212684778
Pubmed

Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons.

LHX4 LHX3

2.93e-06260238970652
Pubmed

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.

PIK3CB PIK3R2

2.93e-06260211752399
Pubmed

Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.

OBSCN MYBPC3

2.93e-06260219403693
Pubmed

Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.

LHX4 LHX3

2.93e-06260215567726
Pubmed

Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival.

PIK3CB PIK3R2

2.93e-06260221383062
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

HAVCR1 TLNRD1 ADAM23 PIK3CB PIK3R2 NOTCH1 JAM2

8.43e-0642460721731673
Pubmed

Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain.

ADAM23 ADAM11

8.77e-0636029693107
Pubmed

Inhibition of the PI3K/AKT pathway reduces tumor necrosis factor-alpha production in the cellular response to wear particles in vitro.

PIK3CB PIK3R2

8.77e-06360223330804
Pubmed

Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1.

TRIP6 ODF1

8.77e-06360212533418
Pubmed

Shear stress-independent binding of von Willebrand factor-type 2B mutants p.R1306Q & p.V1316M to LRP1 explains their increased clearance.

VWF LRP1

8.77e-06360225728415
Pubmed

T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase.

HAVCR1 PIK3R2

8.77e-06360218453570
Pubmed

Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors.

LHX4 LHX3

8.77e-06360210788441
Pubmed

Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.

LHX4 LHX3

8.77e-06360218425848
Pubmed

Recombinant von Willebrand factor-insight into structure and function through infusion studies in animals with severe von Willebrand disease.

VWF LRP1

8.77e-06360211992244
Pubmed

Purification and characterization of phosphoinositide 3-kinase from rat liver.

PIK3CB PIK3R2

8.77e-0636022174051
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

ERGIC3 LRP1 LAMB3 MUC5B CRTAP

9.71e-0616460532409323
Pubmed

Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor.

GRK4 GRK6

1.75e-05460210379886
Pubmed

Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3.

LHX3 NOTCH1

1.75e-0546027665181
Pubmed

Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.

LHX4 LHX3

1.75e-05460222025611
Pubmed

Linkage mapping of the gene for the LIM-homeoprotein LIM3 (locus Lhx3) to mouse chromosome 2.

LHX3 NOTCH1

2.92e-0556028597642
Pubmed

Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons.

LHX4 LHX3

2.92e-05560215607939
Pubmed

Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.

PIK3CB PIK3R2

2.92e-0556027479742
Pubmed

Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival.

PIK3CB PIK3R2

4.37e-05660210949031
Pubmed

The emerging mechanisms of isoform-specific PI3K signalling.

PIK3CB PIK3R2

4.37e-05660220379207
Pubmed

Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.

LHX4 LHX3

4.37e-05660220534763
Pubmed

The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.

GRK4 GRK6

4.37e-05660210506199
Pubmed

Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene.

LHX4 LHX3

6.11e-05760214714741
Pubmed

Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin.

SLC32A1 LHX3

6.11e-05760224485459
Pubmed

Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.

GRK4 GRK6

6.11e-0576028672451
Pubmed

Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

GRK4 GRK6

6.11e-05760211517230
Pubmed

Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes.

PIK3CB PIK3R2

8.14e-05860222402981
Pubmed

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.

PIK3CB PIK3R2

8.14e-05860212167717
Pubmed

Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6.

VWF EGR4

8.14e-0586027987303
Pubmed

Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.

PIK3CB PIK3R2

8.14e-05860217846664
Pubmed

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development.

VWF NOTCH1

8.14e-05860218245384
Pubmed

Formation of Rathke's pouch requires dual induction from the diencephalon.

LHX4 LHX3

1.05e-0496029806931
Pubmed

Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat.

PIK3CB PIK3R2

1.05e-04960221765914
Pubmed

Biological, clinical and population relevance of 95 loci for blood lipids.

IRF2BP2 HAVCR1 ERGIC3 LRP1

1.21e-0414660420686565
Pubmed

The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.

PIK3CB PIK3R2

1.31e-04106028636073
Pubmed

A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.

LHX3 NOTCH1

1.31e-041060217728344
Pubmed

Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.

PIK3CB PIK3R2

1.31e-04106028798481
Pubmed

Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity.

PIK3CB PIK3R2

1.31e-04106029247029
Pubmed

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade.

PIK3CB PIK3R2

1.59e-041160223604317
Pubmed

Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.

VWF NOTCH1

1.59e-041160215875024
Pubmed

Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia.

LHX4 LHX3

1.59e-041160225668206
Pubmed

HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.

PIK3CB PIK3R2

1.59e-041160216081599
Pubmed

HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.

PIK3CB PIK3R2

1.59e-04116029708406
Pubmed

HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line.

PIK3CB PIK3R2

1.59e-041160210985305
Pubmed

Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells.

PIK3CB PIK3R2

1.59e-041160212584329
Pubmed

Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL.

PIK3CB PIK3R2

1.59e-041160234831026
Pubmed

Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.

PIK3CB PIK3R2

1.59e-04116029808187
Pubmed

HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway.

PIK3CB PIK3R2

1.59e-041160225104021
Pubmed

Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.

PIK3CB PIK3R2

1.91e-041260214602571
Pubmed

LIFR beta plays a major role in neuronal identity determination and glial differentiation in the mouse facial nucleus.

LIFR LHX4

1.91e-041260218031722
Pubmed

Specification of pituitary cell lineages by the LIM homeobox gene Lhx3.

LHX4 LHX3

1.91e-04126028638120
Pubmed

Molecular basis of pituitary dysfunction in mouse and human.

LHX4 LHX3

1.91e-041260211420609
Pubmed

Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes.

LHX4 LHX3

1.91e-041260215053981
Pubmed

HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.

PIK3CB PIK3R2

1.91e-041260210208934
Pubmed

Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.

PIK3CB PIK3R2

1.91e-041260212077252
Pubmed

Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.

PIK3CB PIK3R2

1.91e-04126029341793
Pubmed

An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development.

LIFR LHX3

1.91e-041260230658714
Pubmed

Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.

PIK3CB PIK3R2

1.91e-041260212551992
Pubmed

HIV-1 Nef in macrophage-mediated disease pathogenesis.

PIK3CB PIK3R2

2.26e-041360223215766
Pubmed

Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.

PIK3CB PIK3R2

2.26e-041360227799550
Pubmed

Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.

PIK3CB PIK3R2

2.26e-04136029394803
Pubmed

Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.

VWF NOTCH1

2.26e-041360220558824
Pubmed

Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23.

ADAM23 ADAM11

2.26e-041360210433968
Pubmed

LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons.

LHX4 LHX3

2.26e-04136029865699
Pubmed

Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.

PIK3CB PIK3R2

2.63e-041460217157319
Pubmed

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.

MUC5B NOTCH1

2.63e-041460222797898
Pubmed

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.

SEMA3B NOTCH1

2.63e-041460222955271
Pubmed

CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain.

LIFR NOTCH1

2.63e-041460215634701
Pubmed

Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord.

LHX3 NOTCH1

2.63e-041460217359917
Pubmed

Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment.

VWF LAMB3

2.63e-041460236347239
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

IRF2BP2 TRIP6 LRP1 NOTCH1

2.93e-0418460432908313
Pubmed

HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex.

PIK3CB PIK3R2

3.03e-041560218854243
Pubmed

Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors.

LHX4 EPHA8

3.03e-041560231260032
Pubmed

Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action.

PIK3CB PIK3R2

3.03e-041560220702582
Pubmed

Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis.

VWF NOTCH1

3.03e-041560224755984
Pubmed

Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons.

SLC32A1 NOTCH1

3.03e-041560216715081
Pubmed

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.

LHX4 LHX3

3.03e-04156029230312
Pubmed

Multistep control of pituitary organogenesis.

LHX4 LHX3

3.03e-04156029388186
Pubmed

HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.

PIK3CB PIK3R2

3.46e-041660216524887
Pubmed

HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.

PIK3CB PIK3R2

3.46e-041660211289809
Pubmed

Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice.

PIK3CB PIK3R2

3.46e-041660220019835
Pubmed

Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina.

LHX4 LHX3

3.46e-041660224333658
Pubmed

Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.

PIK3CB PIK3R2

3.46e-041660220818790
Pubmed

Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes.

PIK3CB PIK3R2

3.91e-041760223251686
Pubmed

Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.

PIK3CB PIK3R2

3.91e-041760212960231
Pubmed

Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages.

PIK3CB PIK3R2

3.91e-041760218453587
Pubmed

HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.

PIK3CB PIK3R2

4.40e-041860212526811
Pubmed

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis.

LHX4 LHX3

4.40e-041860210499586
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NWD2 PCLO TLN2

4.67e-048760312465718
Pubmed

Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.

PIK3CB PIK3R2

4.91e-041960231959764
Pubmed

HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation.

PIK3CB PIK3R2

4.91e-041960224073214
Pubmed

FOXL2 in the pituitary: molecular, genetic, and developmental analysis.

LHX4 LHX3

4.91e-041960216840539
GeneFamilyLIM class homeoboxes

LHX4 LHX3

3.59e-0412432522
GeneFamilyFibronectin type III domain containing

LIFR OBSCN EPHA8 MYBPC3

5.57e-04160434555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

LRRC24 OBSCN JAM2 MYBPC3

5.70e-04161434593
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM23 ADAM11

1.87e-032743247
GeneFamilyADAM metallopeptidase domain containing|CD molecules

LIFR HAVCR1 LRP1 BCAM JAM2

2.33e-03394435471
CoexpressionKIM_GASTRIC_CANCER_CHEMOSENSITIVITY

TSHZ2 SGTA ABCB8 KDM4B

6.76e-0595604M14702
CoexpressionNABA_MATRISOME

VWF NRTN ADAM23 SULF1 SEMA3B LAMB3 LOXL4 MUC5B MST1L ADAM11

8.89e-0510086010MM17056
CoexpressionGSE2706_UNSTIM_VS_8H_LPS_AND_R848_DC_UP

IRF2BP2 ITFG2 TMLHE KDM4B CRTAP

9.12e-05198605M4704
CoexpressionGSE22886_IGM_MEMORY_BCELL_VS_BM_PLASMA_CELL_DN

ERGIC3 TRIP6 ABCB8 OBSCN MUC5B

9.34e-05199605M4457
CoexpressionHALLMARK_APICAL_JUNCTION

VWF NRTN ADAM23 PIK3CB LAMB3

9.56e-05200605M5915
CoexpressionFOSTER_KDM1A_TARGETS_DN

PIK3R2 GRK6 BCAM ATP2A3 KDM4B

1.00e-04202605M2514
CoexpressionNABA_MATRISOME

VWF NRTN ADAM23 SULF1 SEMA3B LAMB3 LOXL4 MUC5B MST1L ADAM11

1.03e-0410266010M5889
CoexpressionFOSTER_KDM1A_TARGETS_DN

PIK3R2 GRK6 BCAM ATP2A3 KDM4B

1.07e-04205605MM957
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLCD3 VWF SULF1 BCAM ATP2A3 JAM2

2.10e-071896062e43428f1ef9683c6f8c9897d46aa7d34bf9047f
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LIFR VWF TSHZ2 OBSCN BCAM JAM2

2.31e-071926061990dc8a81594018a5bf596be99d0b5f0af0f58f
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-SVEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LIFR VWF TSHZ2 ADAM23 BCAM JAM2

2.31e-07192606c3dda7c48732b0b8bde36de282d64192f5e9b98f
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LIFR VWF TSHZ2 OBSCN BCAM JAM2

2.31e-07192606845cc9c18b4436b07dd3ce7980052683937546d2
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LIFR VWF TSHZ2 OBSCN BCAM JAM2

2.31e-07192606c72a082c93a8825adbfef37f889ba3a7052f201b
ToppCellP15-Endothelial-large_vessel_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWF TSHZ2 SULF1 BCAM NOTCH1 JAM2

2.38e-071936065f9a7cd5f8eb9ac294cdb50518fedf872f3f78f5
ToppCellIPF-Endothelial-VE_Peribronchial|IPF / Disease state, Lineage and Cell class

LIFR VWF TSHZ2 ADAM23 BCAM JAM2

2.53e-071956062c3ad3cb79f11119ac69c413a938d21199145040
ToppCelldistal-Endothelial-Bronchial_Vessel_1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF TSHZ2 ADAM23 BCAM JAM2

2.69e-07197606f45a93b5ad80a16b760acbaa6467648ffc05a0d3
ToppCellcellseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-SVEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LIFR VWF TSHZ2 ADAM23 BCAM JAM2

2.77e-0719860639c90d8de44d8229843ee84b39e69be1b7d67ab4
ToppCelldistal-3-Endothelial-Bronchial_Vessel_1|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF TSHZ2 ADAM23 BCAM JAM2

2.77e-0719860600fdee373eaa43c9ce897f2ba2ecbe94cedea93a
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LIFR VWF TSHZ2 ADAM23 BCAM JAM2

2.93e-07200606a3b09580738783c6bff31ea33d5188912e56b8a7
ToppCelldroplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR HAVCR1 TMLHE OBSCN ADAM11

3.26e-061696057962165cab84af73d20b56eb70b1ed87c94025ef
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLCD3 VWF TSHZ2 OBSCN JAM2

3.35e-06170605af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

PLCD3 SEMA3B LAMB3 LOXL4 MUC5B

3.55e-061726050be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLCD3 VWF TSHZ2 OBSCN JAM2

3.55e-061726059a1743abcd5fbd38253ea84d88ad716cfb71de36
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D231|Adult / Lineage, Cell type, age group and donor

LIFR VWF ADAM23 ADAM11 JAM2

3.75e-061746052dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D175|Adult / Lineage, Cell type, age group and donor

LIFR VWF SULF1 HHIPL1 JAM2

3.86e-061756050a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCellfacs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF2BP2 LIFR HAVCR1 OBSCN ADAM11

3.97e-0617660574f851a398c7562dd713bc0d8d488c0037243112
ToppCellfacs-Marrow-T_cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF2BP2 LIFR HAVCR1 OBSCN ADAM11

3.97e-0617660531b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCellnormal_Lung-Endothelial_cells-EPCs|normal_Lung / Location, Cell class and cell subclass

LIFR HAVCR1 VWF NOTCH1 JAM2

3.97e-0617660571d1bd425772d89d8c550b909e0ec0e36ff22a7e
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF TSHZ2 SULF1 CRTAP JAM2

4.08e-061776056f6cf93893daac6ae228df36219ee3acf8de8f97
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLCD3 GALE PIK3CB LAMB3 ATP2A3

4.08e-061776051f5b6498364b2017c4d49cd337d6e91c8e4f840d
ToppCellfacs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF2BP2 LIFR HAVCR1 OBSCN ADAM11

4.43e-06180605bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCellfacs-Marrow-B-cells-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF2BP2 LIFR HAVCR1 OBSCN ADAM11

4.43e-06180605839defb40f7cfb2711e9025194de636533f51bcd
ToppCellfacs-Marrow-B-cells-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF2BP2 LIFR HAVCR1 OBSCN ADAM11

4.43e-0618060582965ed1b72a1873c24dd4553d39681596057316
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF SULF1 BCAM SEC31B JAM2

4.55e-061816054ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF TSHZ2 BCAM JAM2

4.80e-06183605a644258ba90acc62d571623e429d72ffc4b69203
ToppCelldroplet-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLCD3 VWF SULF1 BCAM JAM2

5.06e-06185605eeb6f55a6f79adf80247baa2c4b0df44553557ad
ToppCellCOPD-Endothelial-VE_Peribronchial|World / Disease state, Lineage and Cell class

LIFR VWF TSHZ2 BCAM JAM2

5.06e-061856054abe04198ab5047c211f8d09cdb9650fa52a3cd6
ToppCellcellseq-Epithelial-Epithelial_Glandular-MEC-MEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PLCD3 TSHZ2 LAMB3 LOXL4 BCAM

5.06e-0618560576304829fcfb5934188933ca20d33bc8c8b0dc91
ToppCellcellseq-Epithelial-Epithelial_Glandular-MEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PLCD3 TSHZ2 LAMB3 LOXL4 BCAM

5.06e-061856050595e7ab37eed690f6e3d16a9a4e9a4bce2b89db
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLCD3 VWF SULF1 TLN2 JAM2

5.20e-06186605c116cc9f41971622264434ebe29d18e719b0ae19
ToppCellCOPD-Endothelial-VE_Peribronchial|COPD / Disease state, Lineage and Cell class

LIFR VWF TSHZ2 BCAM JAM2

5.20e-0618660523c7d0e8372a71546d687278b985f761d282f92f
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWF SULF1 ATP2A3 NOTCH1 JAM2

5.33e-0618760566ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF SULF1 ATP2A3 NOTCH1 JAM2

5.33e-061876057170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWF SULF1 BCAM NOTCH1 JAM2

5.47e-0618860550b27fc12347ca16bd62333baf345c83cb422a8f
ToppCellControl-Endothelial-VE_Peribronchial|Control / Disease state, Lineage and Cell class

LIFR VWF TSHZ2 ADAM23 JAM2

5.47e-06188605f5b7dbc89f992c13280d36a34935be83906b1bc0
ToppCellControl-Endothelial-VE_Peribronchial|World / Disease state, Lineage and Cell class

LIFR VWF TSHZ2 ADAM23 JAM2

5.62e-06189605c76d8af2e0aa4a83ee0c3439c894566fbf117dd3
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

5.91e-06191605adb2e3efcad02889d8229325080da5e7830fd3ae
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR VWF TSHZ2 BCAM JAM2

5.91e-061916059fc674a58f20b47255e4457d5195c8cff17b0414
ToppCellP03-Endothelial-large_vessel_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWF SULF1 ATP2A3 NOTCH1 JAM2

5.91e-06191605b680e0c35f1004be36f9f0680ae3c62952e2b607
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF SULF1 BCAM ATP2A3 JAM2

5.91e-061916056e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF SULF1 BCAM ATP2A3 JAM2

5.91e-06191605482db995930346be69072ace2fd78fd453e97fb5
ToppCelldroplet-Lung-LUNG-1m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR VWF TSHZ2 BCAM JAM2

5.91e-06191605c379a499dabf3c9ed80f47adbb2d949821c5b053
ToppCellCOPD-Endothelial|COPD / Disease state, Lineage and Cell class

LIFR VWF TSHZ2 BCAM JAM2

6.22e-06193605093b28dcccb5841c995d0b33fae0efd6b88f97e0
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF TSHZ2 BCAM JAM2

6.22e-06193605c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCellIPF-Endothelial|IPF / Disease state, Lineage and Cell class

LIFR VWF TSHZ2 BCAM JAM2

6.38e-061946059591993aa2dcba3d09a0f1ea8b8f2439c26482d6
ToppCellIPF-Endothelial-VE_Peribronchial|World / Disease state, Lineage and Cell class

LIFR VWF TSHZ2 BCAM JAM2

6.54e-06195605120296531bbc8080dcabacbd64733cc1dc34603a
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LIFR VWF ADAM23 BCAM JAM2

6.70e-06196605d5d3028fcbfa251a206d17ec33b3b313968f9d79
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR TLNRD1 ADAM23 CRTAP JAM2

6.70e-0619660581900dcc9451ff6606ec940c16b559d73247590e
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

6.87e-0619760561b1b10a017cbeb17f8529fcae66cba77ee2f115
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

6.87e-0619760587eda06344498dc66cac292cf89746dc90b5cf67
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

6.87e-06197605e8e879b7634a29569061d3515d180784094a31e7
ToppCelldistal-Endothelial-Bronchial_Vessel_1-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF TSHZ2 BCAM JAM2

6.87e-061976050d1afd1ad7489c071db08b3dfff598423097d7e0
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LIFR VWF ADAM23 BCAM JAM2

7.04e-0619860568ee0baa2f5cf239f2356cc59fee9041a7732bba
ToppCell390C-Endothelial_cells-Endothelial-A_(Artery)-|390C / Donor, Lineage, Cell class and subclass (all cells)

LIFR VWF ADAM23 BCAM JAM2

7.04e-06198605f83956c4b13b5d0a0c6e3d9f580dbf99649ef175
ToppCelldistal-Endothelial-Artery-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF SULF1 BCAM JAM2

7.04e-06198605f284f59f4ebe55ee132eddfaa2f5d9ecb059654f
ToppCell5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

7.04e-06198605d1f54ed3ef5e05ebda7da999e172d168dc6802cd
ToppCell5'-Adult-Distal_Rectal-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

7.04e-061986058d6b0b9da7c1e64155cbcbb04ad38d129a29030c
ToppCelldistal-Endothelial-Bronchial_Vessel_1-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

VWF TSHZ2 ADAM23 BCAM JAM2

7.04e-061986055bdffabf80716dd80c1265c3d126c7a25340251c
ToppCelldistal-1-Endothelial-Bronchial_Vessel_1|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF TSHZ2 BCAM JAM2

7.04e-061986055cd81fe1a21c0e1a7f0d5a62ddf8e422b05aedc7
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

7.04e-0619860558508a8df2714d769f137794c29441a7bd38b350
ToppCell390C-Endothelial_cells-Endothelial-A_(Artery)|390C / Donor, Lineage, Cell class and subclass (all cells)

LIFR VWF ADAM23 BCAM JAM2

7.04e-061986055b5ccce5de82ea041465e656147cec3b8beb865b
ToppCelldistal-3-Endothelial-Artery|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF SULF1 BCAM JAM2

7.22e-061996057814804f4ecc0655610e5c85f513b3976d856192
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

7.22e-0619960507bda4ac8ffdce1a865ebc99e46c2a27925ff7a8
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TSHZ2 OBSCN LAMB3 LOXL4 BCAM

7.22e-0619960594a7867e800df352731796de8c24cba133c29622
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

VWF TSHZ2 SULF1 ATP2A3 JAM2

7.22e-061996059b02acae6325b0ac9642438a4431285ff396e5fe
ToppCelldistal-Endothelial-Artery|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF SULF1 BCAM JAM2

7.22e-06199605b6e9aaac047d4b64b9d97f5e174e89a424d8b36d
ToppCellmedial-Endothelial-Artery|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF SULF1 BCAM JAM2

7.22e-06199605341c0be18bec66f4cc8bda232dce54edb34b9cda
ToppCellmedial-2-Endothelial-Artery|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF SULF1 BCAM JAM2

7.22e-0619960553c17c0493f82351a039bc64def191311e0f4951
ToppCelldistal-Endothelial-Artery-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF SULF1 BCAM JAM2

7.22e-061996058acf381087268fcf13f025e3b67e028bf1f9b77e
ToppCellmedial-Endothelial-Artery-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF SULF1 BCAM JAM2

7.22e-06199605c455f5a2802f2ec6f0e24266de1aaf3203ca8c78
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_venous|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LIFR VWF ADAM23 BCAM JAM2

7.22e-06199605d62a2cb81b01ae59969e0b2bbe99c1c9cc96fdaa
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSHZ2 SULF1 LRP1 LOXL4 CRTAP

7.22e-06199605e78f661b40da34768469549b6e755d330be6bbd8
ToppCell5'-Adult-LargeIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

7.22e-06199605ffebd99d55d31cf51b4878b2690ed0b9b3799223
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LIFR VWF TSHZ2 BCAM JAM2

7.22e-061996056fb81388c5045e81c3849a7136bdff3f953f044e
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

7.22e-06199605258d59cf811bf1668ffbb5f18f961021f660de62
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LIFR VWF SULF1 BCAM JAM2

7.39e-06200605ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCellmedial-2-Endothelial-Capillary_Intermediate_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF TSHZ2 BCAM JAM2

7.39e-06200605a8adf5902540f6bb15b72efbb9c389b59d67e001
ToppCellBiopsy_Other_PF-Endothelial|Biopsy_Other_PF / Sample group, Lineage and Cell type

LIFR VWF TSHZ2 BCAM JAM2

7.39e-06200605f9916134486fb1dac55f5e7e8deb35e7a3b85770
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LIFR VWF ADAM23 BCAM JAM2

7.39e-0620060584e145619a500530f42ed0fe72468ae95f4cbf1e
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LIFR VWF ADAM23 BCAM JAM2

7.39e-06200605cb00760ae75c30b1cb8526534aabd4ffc7c21000
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LIFR VWF SULF1 BCAM JAM2

7.39e-062006057547d6339f9380d031cfd2cce21ac9a12491e085
ToppCellmedial-Endothelial-Capillary_Intermediate_1|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF TSHZ2 BCAM JAM2

7.39e-062006053ef7b7728615710c691aed8977e2582f19692cf9
ToppCell390C-Endothelial_cells-Endothelial-A_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LIFR VWF ADAM23 BCAM JAM2

7.39e-0620060550b8788494b744e0f0ec8c4d67a1c90ae09dca65
ToppCell390C-Endothelial_cells-Endothelial-A_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LIFR VWF ADAM23 BCAM JAM2

7.39e-06200605f5f24273bee3259a4a3be99ba53b88defa1286c0
ToppCellproximal-Endothelial-Bronchial_Vessel_1|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF TSHZ2 ADAM23 JAM2

7.39e-06200605d034bd210c87b704acf45f50d888497c8737011b
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

7.39e-06200605cd3c638961144a2fc91c437a173cc37c7452fa74
ToppCell5'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR VWF SULF1 BCAM JAM2

7.39e-062006052554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCellproximal-3-Endothelial-Bronchial_Vessel_1|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF TSHZ2 ADAM23 JAM2

7.39e-062006050ff4185021ec84b57be13b28495e2f8a4d195eb6
ToppCellproximal-Endothelial-Bronchial_Vessel_1-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF TSHZ2 ADAM23 JAM2

7.39e-06200605e4f6e0b9502eb531f28d605f9dbda6a72a9ed320
ToppCellmedial-Endothelial-Capillary_Intermediate_1-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LIFR VWF TSHZ2 BCAM JAM2

7.39e-06200605707148e01e961097819a05437a842b7d3bf72b0a
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF SULF1 JAM2 MYBPC3

2.02e-05119604c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCell21-Trachea-Immune-Immune|Trachea / Age, Tissue, Lineage and Cell class

EGR4 PCLO LOXL4 HHIPL1

3.22e-051346044f0465324cc5b443ebadb68aef63be79b74f6ff9
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Cerebellum / BrainAtlas - Mouse McCarroll V32

SLC32A1 LAMB3 EPHA8 MYBPC3

4.88e-051496046e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCellfacs-Marrow-KLS-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR PIK3CB ADAM11 PPM1J

5.98e-051576045d08ff0ba9d3df9cc30f13cab2d2b395ea6f3446
ToppCellfacs-Marrow-KLS-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR PIK3CB ADAM11 PPM1J

5.98e-05157604ad9c9b7dfeee3ae46e7e593c51a0407df12195b4
ToppCelldroplet-Thymus-nan-21m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ADAM23 SULF1 OBSCN

6.59e-05161604441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

VWF SULF1 ATP2A3 JAM2

7.25e-05165604a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF SULF1 NOTCH1 JAM2

7.42e-051666047a45785a40b7425f97be67bab1c5ceb69b2bd85a
DiseaseCombined pituitary hormone deficiencies, genetic form

LHX4 LHX3

3.92e-055592cv:C4273747
Diseasealcohol use disorder (implicated_via_orthology)

SLC32A1 PIK3CB GRK4 GRK6 NOTCH1

4.49e-05195595DOID:1574 (implicated_via_orthology)
DiseaseAlzheimer disease, APOE carrier status

IRF2BP2 TSHZ2 NOTCH1 KDM4B

4.53e-0598594EFO_0007659, MONDO_0004975
Diseasefactor VIII measurement

VWF TMLHE GRK6

7.12e-0540593EFO_0004630
Diseasepanhypopituitarism (is_implicated_in)

LHX4 LHX3

8.20e-057592DOID:9410 (is_implicated_in)
Diseaseindolelactate measurement

SULF1 ODF1

3.52e-0414592EFO_0020012
Diseasecentral nervous system disease (implicated_via_orthology)

IRF2BP2 SEC31B

4.63e-0416592DOID:331 (implicated_via_orthology)
Diseasehealth study participation

PLCD3 IRF2BP2 PIK3R2 KDM4B

6.34e-04195594EFO_0010130
DiseaseInfiltrating duct carcinoma of female breast

GRK6 EPHA8

8.05e-0421592C3165106
Diseasealkaline phosphatase measurement

IRF2BP2 NWD2 TRIP6 NRTN BCAM NOTCH1 EPHA8 MYBPC3

8.93e-041015598EFO_0004533
DiseaseDrug-Induced Liver Disease

HAVCR1 VWF GRK4 NOTCH1 PPTC7

1.28e-03404595C0860207
DiseaseDrug-Induced Acute Liver Injury

HAVCR1 VWF GRK4 NOTCH1 PPTC7

1.28e-03404595C3658290
DiseaseChemical and Drug Induced Liver Injury

HAVCR1 VWF GRK4 NOTCH1 PPTC7

1.28e-03404595C4277682
DiseaseHepatitis, Drug-Induced

HAVCR1 VWF GRK4 NOTCH1 PPTC7

1.28e-03404595C1262760
DiseaseHepatitis, Toxic

HAVCR1 VWF GRK4 NOTCH1 PPTC7

1.28e-03404595C0019193
DiseaseChemically-Induced Liver Toxicity

HAVCR1 VWF GRK4 NOTCH1 PPTC7

1.28e-03404595C4279912
Diseaseopioid dependence

NWD2 SULF1 ABCB8 TLN2

1.31e-03237594EFO_0005611
DiseaseL-arginine measurement

PDHA1 GRK6

1.34e-0327592EFO_0006524

Protein segments in the cluster

PeptideGeneStartEntry
RGYECRDAVNECDIT

ADAM23

556

O75077
YEPRGVSCREAVNEC

ADAM11

496

O75078
EVAACITRCYQAGIR

ATP2A3

606

Q93084
ECEEISGVIASYRRC

CPNE6

386

O95741
NSCYERVCSALEARG

NWD2

1721

Q9ULI1
LEAYAELCRARGVCS

MUC5B

5331

Q9HC84
LFRYCAGACEAAARV

NRTN

126

Q99748
SEVRCRGYERTLSDC

LOXL4

376

Q96JB6
VVDRRGVADYACSCA

NOTCH1

76

P46531
AREGFECYDRSLCAN

HHIPL1

441

Q96JK4
VGFCYQIRRCTDDVR

MST1L

336

Q2TV78
AADGSRQCRCTAYFE

LRP1

4321

Q07954
DLTAGRRAVCCDVVY

PCLO

2931

Q9Y6V0
CNTCEDVREAYRRRG

ERGIC3

156

Q9Y282
RCRVIGAASQTCYEV

KDM4B

936

O94953
ACRCYSATVECGALR

LRRC24

26

Q50LG9
AERCFSRGESVYCKD

LHX3

66

Q9UBR4
DRCFSRAGSVYCKED

LHX4

66

Q969G2
GIYSVRECKSSDCRR

FLVCR1-DT

56

Q8TAF5
FACDVCGRRFARSDE

EGR4

541

Q05215
EYSCEARNSVGYRRC

JAM2

211

P57087
ARYQEEAEREGLACC

MROH1

676

Q8NDA8
GKVCVSAERENRYDC

ODF1

146

Q14990
VDENIRAFCAGLYAC

ITFG2

346

Q969R8
QGACRSLTIYRCEFA

OBSCN

2216

Q5VST9
ACYGDDACFVARHRS

PPTC7

56

Q8NI37
IRESSQRGCYACSVV

PIK3R2

646

O00459
VVARREGDVAACYAN

GALE

296

Q14376
CVACALRAGRAQYER

CRTAP

16

O75718
VCSAGYEERRDACVA

EPHA8

261

P29322
YEERRDACVACELGF

EPHA8

266

P29322
IRCHVYDRAARVCGS

GK5

31

Q6ZS86
DRTYGDVATGCRACD

LAMB3

521

Q13751
YRCRLAAAVRDCDQS

CCDC144A

916

A2RUR9
EQRAVFYAAELCCGL

GRK4

286

P32298
ARAVFYAAEICCGLE

GRK6

286

P43250
RDYVCVVRAGAAGTA

BCAM

121

P50895
AVAAASRRQSCYLCD

IRF2BP2

6

Q7Z5L9
VCRGCVNYEGADRVE

IRF2BP2

36

Q7Z5L9
GTDYEVCIENRSRSC

LIFR

76

P42702
RYGAELEACRCRAEE

ABCB8

356

Q9NUT2
LVSSSGRCIRDEECY

REXO1

981

Q8N1G1
YAGAVQDCERAICID

SGTA

141

O43765
RLAACGAEAAAYGRC

NDUFAF8

21

A1L188
AVSDSGVYCCRVEHR

HAVCR1

96

Q96D42
DQACCEVVYVEGRRS

PPM1J

121

Q5JR12
EARLCYVCSGSVERL

SEC31B

681

Q9NQW1
RAIEEFTLSCAGYCV

PIK3CB

896

P42338
GIIFTEDYRTRVCDC

STK19

211

P49842
AVERRAYCEGCYVAT

TRIP6

321

Q15654
RNCRYDVCSCSDGRE

VWF

606

P04275
CVREATRFAAAYCRS

PDHA1

261

P08559
CGRDCYAIRVATALT

SLC26A1

171

Q9H2B4
STEAYVRAFAQGCRC

PLCD3

366

Q8N3E9
RTCCYQALLVDEERG

SEMA3B

51

Q13214
YRVTRCRHEVEQGCA

TLNRD1

151

Q9H1K6
GASRFRCRQCSAAYD

TSHZ2

211

Q9NRE2
RECDYSIDGINRCIR

TLN2

1661

Q9Y4G6
RVRDSYVAIANACCA

SLC32A1

181

Q9H598
DKECSCRESGYRASR

SULF1

501

Q8IWU6
CGCYLTRDDVLNTAR

TMLHE

401

Q9NVH6
AAETTVELVYRCDGC

ZNF628

286

Q5EBL2
YVCRATNLQGEARCE

MYBPC3

1251

Q14896