Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranslation activator activity

DAZ4 DAZ1 DAZ3 DAZ2

1.63e-0715684GO:0008494
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

MYC HOXD3 ZNF658 BARHL2 GATA3 TFDP3 PLAG1 ZNF658B FOXJ3 NOTCH1

1.87e-055606810GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

MYC HOXD3 ZNF658 BARHL2 GATA3 TFDP3 PLAG1 ZNF658B FOXJ3 NOTCH1

2.05e-055666810GO:0001216
GeneOntologyMolecularFunctionstructural constituent of egg coat

ZP1 ZP2

1.14e-045682GO:0035804
GeneOntologyMolecularFunctionacrosin binding

ZP1 ZP2

1.70e-046682GO:0032190
GeneOntologyMolecularFunctiontranslation regulator activity, nucleic acid binding

DAZ4 DAZ1 DAZ3 DAZ2

5.79e-04112684GO:0090079
GeneOntologyBiologicalProcessfemale meiosis II

DAZ4 DAZ1 DAZ3 DAZ2

1.52e-096674GO:0007147
GeneOntologyBiologicalProcessmeiosis II

DAZ4 DAZ1 DAZ3 DAZ2

1.52e-096674GO:0007135
GeneOntologyBiologicalProcessmeiosis II cell cycle process

DAZ4 DAZ1 DAZ3 DAZ2

1.52e-096674GO:0061983
GeneOntologyBiologicalProcesspositive regulation of meiotic nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

1.44e-0626674GO:0045836
GeneOntologyBiologicalProcesspositive regulation of translational initiation

DAZ4 DAZ1 DAZ3 DAZ2

2.27e-0629674GO:0045948
GeneOntologyBiologicalProcess3'-UTR-mediated mRNA stabilization

DAZ4 DAZ1 DAZ3 DAZ2

2.99e-0631674GO:0070935
GeneOntologyBiologicalProcesspositive regulation of nuclear division

MET DAZ4 DAZ1 DAZ3 DAZ2

4.50e-0675675GO:0051785
GeneOntologyBiologicalProcesspositive regulation of meiotic cell cycle

DAZ4 DAZ1 DAZ3 DAZ2

6.19e-0637674GO:0051446
GeneOntologyBiologicalProcessgland development

HOXA11 CYP1A1 MET GAK HOXD3 BTBD7 GATA3 DUOX2 PLAG1 NOTCH1

1.20e-055586710GO:0048732
GeneOntologyBiologicalProcessregulation of meiotic nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

1.37e-0545674GO:0040020
GeneOntologyBiologicalProcessoocyte maturation

DAZ4 DAZ1 DAZ3 DAZ2

1.63e-0547674GO:0001556
GeneOntologyBiologicalProcessfemale meiotic nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

2.45e-0552674GO:0007143
GeneOntologyBiologicalProcessnephron epithelium development

MYC MAGI2 HOXA11 GATA3 NOTCH1

6.04e-05128675GO:0072009
GeneOntologyBiologicalProcesstranslational initiation

DAZ4 DAZ1 DHX33 DAZ3 DAZ2

6.99e-05132675GO:0006413
GeneOntologyBiologicalProcessembryonic organ development

MYC HOXA11 FBXW8 HOXD3 RBPMS2 GATA3 CC2D2A PCDH12 NOTCH1

8.02e-05561679GO:0048568
GeneOntologyBiologicalProcessmRNA stabilization

DAZ4 DAZ1 DAZ3 DAZ2

1.15e-0477674GO:0048255
GeneOntologyBiologicalProcesspositive regulation of translation

DAZ4 BARHL2 DAZ1 DAZ3 DAZ2

1.32e-04151675GO:0045727
GeneOntologyBiologicalProcessregulation of meiotic cell cycle

DAZ4 DAZ1 DAZ3 DAZ2

1.47e-0482674GO:0051445
GeneOntologyBiologicalProcessregulation of reproductive process

ZP1 DAZ4 DAZ1 DAZ3 DAZ2 ZP2

1.64e-04251676GO:2000241
GeneOntologyBiologicalProcesskidney epithelium development

MYC MAGI2 HOXA11 GATA3 NOTCH1

1.83e-04162675GO:0072073
GeneOntologyBiologicalProcessnegative regulation of mRNA catabolic process

DAZ4 DAZ1 DAZ3 DAZ2

1.85e-0487674GO:1902373
GeneOntologyBiologicalProcesspositive regulation of gene expression

MYC MET HOXD3 HLA-DPA1 DAZ4 BARHL2 GATA3 SIGLEC16 PLAG1 DAZ1 DHX33 DAZ3 DAZ2 NOTCH1

1.89e-0414466714GO:0010628
GeneOntologyBiologicalProcessRNA stabilization

DAZ4 DAZ1 DAZ3 DAZ2

1.93e-0488674GO:0043489
GeneOntologyBiologicalProcessregulation of translational initiation

DAZ4 DAZ1 DAZ3 DAZ2

2.20e-0491674GO:0006446
GeneOntologyBiologicalProcessregulation of nuclear division

MET DAZ4 DAZ1 DAZ3 DAZ2

2.42e-04172675GO:0051783
GeneOntologyBiologicalProcessnephron development

MYC MAGI2 HOXA11 GATA3 NOTCH1

2.55e-04174675GO:0072006
GeneOntologyBiologicalProcessgland morphogenesis

MET BTBD7 DUOX2 PLAG1 NOTCH1

2.83e-04178675GO:0022612
GeneOntologyBiologicalProcessoocyte development

DAZ4 DAZ1 DAZ3 DAZ2

3.04e-0499674GO:0048599
GeneOntologyBiologicalProcessnegative regulation of RNA catabolic process

DAZ4 DAZ1 DAZ3 DAZ2

3.28e-04101674GO:1902369
GeneOntologyBiologicalProcesspositive regulation of cell cycle

MYC CYP1A1 MET DAZ4 DAZ1 DAZ3 DAZ2

3.47e-04407677GO:0045787
GeneOntologyBiologicalProcessoocyte differentiation

DAZ4 DAZ1 DAZ3 DAZ2

3.53e-04103674GO:0009994
GeneOntologyBiologicalProcessnegative regulation of fertilization

ZP1 ZP2

3.69e-049672GO:0060467
GeneOntologyBiologicalProcessprevention of polyspermy

ZP1 ZP2

3.69e-049672GO:0060468
GeneOntologyBiologicalProcessregulation of animal organ morphogenesis

HOXA11 MET BTBD7 GATA3

4.53e-04110674GO:2000027
GeneOntologyBiologicalProcessnephron tubule development

MYC HOXA11 GATA3 NOTCH1

4.53e-04110674GO:0072080
GeneOntologyBiologicalProcesscamera-type eye development

CYP1A1 HCN1 BARHL2 GATA3 CC2D2A DCX NOTCH1

4.56e-04426677GO:0043010
GeneOntologyBiologicalProcessepithelial cell differentiation involved in kidney development

MAGI2 GATA3 NOTCH1

4.80e-0447673GO:0035850
GeneOntologyBiologicalProcesspositive regulation of cell cycle process

CYP1A1 MET DAZ4 DAZ1 DAZ3 DAZ2

4.82e-04307676GO:0090068
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

DAZ4 DAZ1 DAZ3 DAZ2

5.36e-04115674GO:1903312
GeneOntologyBiologicalProcessrenal tubule development

MYC HOXA11 GATA3 NOTCH1

5.54e-04116674GO:0061326
GeneOntologyBiologicalProcessregulation of branching involved in salivary gland morphogenesis

MET BTBD7

5.61e-0411672GO:0060693
GeneOntologyBiologicalProcesssensory organ development

MYC CYP1A1 HCN1 BARHL2 GATA3 CC2D2A DUOX2 DCX NOTCH1

5.65e-04730679GO:0007423
GeneOntologyBiologicalProcesspositive regulation of reproductive process

DAZ4 DAZ1 DAZ3 DAZ2

5.91e-04118674GO:2000243
GeneOntologyBiologicalProcessneuron migration

MET BARHL2 GATA3 ADGRG1 DCX

7.14e-04218675GO:0001764
GeneOntologyBiologicalProcessanimal organ morphogenesis

MYC HOXA11 MET GAK HOXD3 BTBD7 HCN1 RBPMS2 GATA3 DUOX2 PLAG1 NOTCH1

7.17e-0412696712GO:0009887
GeneOntologyBiologicalProcesspositive regulation of cell development

MYC HOXA11 MET FBXW8 GATA3 PLAG1 DCX NOTCH1

8.19e-04614678GO:0010720
GeneOntologyBiologicalProcesscell differentiation involved in kidney development

MAGI2 GATA3 NOTCH1

8.46e-0457673GO:0061005
GeneOntologyBiologicalProcesseye development

CYP1A1 HCN1 BARHL2 GATA3 CC2D2A DCX NOTCH1

9.22e-04480677GO:0001654
GeneOntologyBiologicalProcessvisual system development

CYP1A1 HCN1 BARHL2 GATA3 CC2D2A DCX NOTCH1

9.57e-04483677GO:0150063
GeneOntologyBiologicalProcessembryonic organ morphogenesis

MYC HOXA11 HOXD3 RBPMS2 GATA3 NOTCH1

9.70e-04351676GO:0048562
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

MYC MET FBXW8 PLAG1 DCX NOTCH1

1.01e-03354676GO:0050769
GeneOntologyBiologicalProcessanatomical structure maturation

DAZ4 GATA3 DAZ1 DAZ3 DAZ2 NOTCH1

1.01e-03354676GO:0071695
GeneOntologyBiologicalProcessmorphogenesis of a branching epithelium

MYC HOXA11 MET BTBD7 NOTCH1

1.02e-03236675GO:0061138
GeneOntologyBiologicalProcesssensory system development

CYP1A1 HCN1 BARHL2 GATA3 CC2D2A DCX NOTCH1

1.05e-03491677GO:0048880
GeneOntologyBiologicalProcessegg activation

ZP1 ZP2

1.06e-0315672GO:0007343
GeneOntologyBiologicalProcessregulation of glial cell proliferation

MYC PLAG1 NOTCH1

1.08e-0362673GO:0060251
GeneOntologyBiologicalProcessprostate gland development

HOXA11 PLAG1 NOTCH1

1.08e-0362673GO:0030850
GeneOntologyBiologicalProcessmeiotic nuclear division

DAZ4 DAZ1 DAZ3 DAZ2 FOXJ3

1.10e-03240675GO:0140013
GeneOntologyBiologicalProcesskidney development

MYC MAGI2 HOXA11 GATA3 CC2D2A NOTCH1

1.31e-03372676GO:0001822
GeneOntologyCellularComponentegg coat

ZP1 ZP2

1.60e-046692GO:0035805
GeneOntologyCellularComponentcentriole

MAGI2 CCP110 FBXW8 STARD9 KIF24

2.61e-04172695GO:0005814
HumanPhenoAbnormal zona pellucida morphology

ZP1 ZP2

2.31e-052252HP:0020156
MousePhenoabsent ovarian follicles

DAZ4 DAZ1 DAZ3 DAZ2

4.03e-0551534MP:0002777
MousePhenodecreased tongue size

MET DPP9 GATA3

7.53e-0522533MP:0009907
MousePhenoabnormal circulating phospholipid level

MPZL3 SPTLC2 OSBPL8

8.64e-0523533MP:0006084
MousePhenofemale infertility

HOXA11 DAZ4 RBPMS2 DUOX2 DAZ1 DAZ3 DAZ2 ZP2

1.43e-04410538MP:0001926
MousePhenodelayed inner ear development

GATA3 DUOX2

2.10e-046532MP:0004664
MousePhenodecreased embryonic neuroepithelium primary cilium number

CCP110 CC2D2A

2.10e-046532MP:0013214
MousePhenothin zona pellucida

ZP1 ZP2

2.10e-046532MP:0009375
PathwayWP_OVARIAN_INFERTILITY

DAZ4 DAZ1 DAZ3 DAZ2 ZP2

7.97e-0835455MM15948
PathwayWP_MALE_INFERTILITY

CYP1A1 DAZ4 DAZ1 DAZ3 DAZ2

9.43e-05145455M39856
Pubmed

Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8.

ZP1 DAZ4 DAZ1 DAZ3 DAZ2 ZP2

9.17e-122570616690745
Pubmed

Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-1147047670487
Pubmed

Male infertility, genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair.

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-11470411694340
Pubmed

The human DAZ genes, a putative male infertility factor on the Y chromosome, are highly polymorphic in the DAZ repeat regions.

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-1147049321470
Pubmed

Polymorphic expression of DAZ proteins in the human testis.

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-11470419223287
Pubmed

Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-11470426232607
Pubmed

[Microdeletion of chromosome Y in male infertility: role of the DAZ gene].

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-11470411688365
Pubmed

Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis?

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-11470412752250
Pubmed

A novel approach for the analysis of DAZ gene copy number in severely idiopathic infertile men.

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-11470411883873
Pubmed

Partial DAZ deletions in a family with five infertile brothers.

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-11470412801575
Pubmed

Analysis of the DAZ gene family in cryptorchidism and idiopathic male infertility.

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-11470415066457
Pubmed

Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome.

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-11470411095434
Pubmed

Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-11470410936047
Pubmed

[Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI].

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-11470416963411
Pubmed

Gene knockouts that cause female infertility: search for novel contraceptive targets.

ZP1 DAZ4 DAZ1 DAZ3 DAZ2 ZP2

1.94e-112870615970507
Pubmed

ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles.

ZP1 DAZ4 DAZ1 DAZ3 DAZ2 ZP2

3.78e-113170631657143
Pubmed

Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570423579190
Pubmed

The dazzle in germ cell differentiation.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570420008336
Pubmed

Isolation of a mouse homolog of the human DAZ (Deleted in Azoospermia) gene.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-1157048679003
Pubmed

AZFc partial deletions in Chilean men with severe spermatogenic failure.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570417416365
Pubmed

Retinoic acid regulates germ cell differentiation in mouse embryonic stem cells through a Smad-dependent pathway.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570422293198
Pubmed

Loss of oocytes in Dazl knockout mice results in maintained ovarian steroidogenic function but altered gonadotropin secretion in adult animals.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570411089564
Pubmed

A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570410393944
Pubmed

The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-1157048968756
Pubmed

A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-1157048968755
Pubmed

DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570430380414
Pubmed

Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570426411291
Pubmed

Somatic cell-derived BMPs induce premature meiosis in male germ cells during the embryonic stage by upregulating Dazl expression.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570434985827
Pubmed

Expression profiling of the developing testis in wild-type and Dazl knockout mice.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570414648873
Pubmed

The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-1157048896558
Pubmed

Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-1157049700189
Pubmed

Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570422021443
Pubmed

The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-1157049288969
Pubmed

Co-culture of spermatogonial stem cells with sertoli cells in the presence of testosterone and FSH improved differentiation via up-regulation of post meiotic genes.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570423456578
Pubmed

In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570410903443
Pubmed

Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-1157049143498
Pubmed

Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570422699882
Pubmed

A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-1157048845845
Pubmed

DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570411058556
Pubmed

Dazl promotes germ cell differentiation from embryonic stem cells.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570419783541
Pubmed

DAZL protein expression in mouse preimplantation embryo.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570417761180
Pubmed

Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570419468308
Pubmed

Partial rescue of the Dazl knockout mouse by the human DAZL gene.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570412200456
Pubmed

Nature of the spermatogenic arrest in Dazl -/- mice.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570411514340
Pubmed

Mouse Dazl and its novel splice variant functions in translational repression of target mRNAs in embryonic stem cells.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570423298641
Pubmed

DAZL is essential for stress granule formation implicated in germ cell survival upon heat stress.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570422223682
Pubmed

Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570423223451
Pubmed

Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570411804965
Pubmed

Decreased oocyte DAZL expression in mice results in increased litter size by modulating follicle-stimulating hormone-induced follicular growth.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-11570421270429
Pubmed

Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty.

DAZ4 DAZ1 DAZ3 DAZ2

7.51e-1157048661148
Pubmed

DAZL binds to the transcripts of several Tssk genes in germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670418452650
Pubmed

A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670424086306
Pubmed

DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670419247806
Pubmed

DAZL is a master translational regulator of murine spermatogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670431355046
Pubmed

Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670420157580
Pubmed

Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of Sox9 and Dazl.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670428496037
Pubmed

DAZL regulates Tet1 translation in murine embryonic stem cells.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670426077710
Pubmed

Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670417526644
Pubmed

The mouse male germ cell-specific gene Tpx-1: molecular structure, mode of expression in spermatogenesis, and sequence similarity to two non-mammalian genes.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-1067041638086
Pubmed

Spermatogenesis in testes of Dazl null mice after transplantation of wild-type germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670414611632
Pubmed

Expression profiles of the DAZ gene family in human testis with and without spermatogenic failure.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670415066460
Pubmed

The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670423417416
Pubmed

The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670432170089
Pubmed

Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670416278232
Pubmed

A gene trap mutation of a murine homolog of the Drosophila stem cell factor Pumilio results in smaller testes but does not affect litter size or fertility.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670417219433
Pubmed

The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670416001084
Pubmed

Cracd Marks the First Wave of Meiosis during Spermatogenesis and Is Mis-Expressed in Azoospermia Mice.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670432962040
Pubmed

Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-1067041869307
Pubmed

A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670411390979
Pubmed

BOULE, a Deleted in Azoospermia Homolog, Is Recruited to Stress Granules in the Mouse Male Germ Cells.

DAZ4 DAZ1 DAZ3 DAZ2

2.25e-10670427632217
Pubmed

Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

5.24e-10770415081113
Pubmed

Sertoli-cell-specific knockout of connexin 43 leads to multiple alterations in testicular gene expression in prepubertal mice.

DAZ4 DAZ1 DAZ3 DAZ2

5.24e-10770422699423
Pubmed

Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL.

DAZ4 DAZ1 DAZ3 DAZ2

5.24e-10770411604102
Pubmed

Dazl can bind to dynein motor complex and may play a role in transport of specific mRNAs.

DAZ4 DAZ1 DAZ3 DAZ2

5.24e-10770416946704
Pubmed

Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.

DAZ4 DAZ1 DAZ3 DAZ2

5.24e-10770410857750
Pubmed

The RNA-binding specificity of the mouse Dazl protein.

DAZ4 DAZ1 DAZ3 DAZ2

5.24e-10770411410654
Pubmed

The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation.

DAZ4 DAZ1 DAZ3 DAZ2

5.24e-1077049588208
Pubmed

DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.

DAZ4 DAZ1 DAZ3 DAZ2

5.24e-10770426826184
Pubmed

The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice.

DAZ4 DAZ1 PCDH12 DAZ3 DAZ2

7.32e-102270523364048
Pubmed

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

DAZ4 DAZ1 DAZ3 DAZ2

1.05e-09870423204224
Pubmed

Requirement of the 3'-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development.

DAZ4 DAZ1 DAZ3 DAZ2

1.05e-09870429883445
Pubmed

A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection.

DAZ4 DAZ1 DAZ3 DAZ2

1.05e-09870410823932
Pubmed

A preliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men.

DAZ4 DAZ1 DAZ3 DAZ2

1.05e-09870411869379
Pubmed

Fanconi anemia complementation group C is required for proliferation of murine primordial germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

1.05e-09870410951504
Pubmed

Mouse dead end1 acts with Nanos2 and Nanos3 to regulate testicular teratoma incidence.

DAZ4 DAZ1 DAZ3 DAZ2

1.05e-09870432339196
Pubmed

Single-cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination.

DAZ4 DAZ1 DAZ3 DAZ2

1.05e-09870433749946
Pubmed

Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice.

DAZ4 DAZ1 DAZ3 DAZ2

1.05e-09870422621333
Pubmed

DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors.

DAZ4 DAZ1 DAZ3 DAZ2

1.05e-09870432686646
Pubmed

Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice.

DAZ4 DAZ1 DAZ3 DAZ2

1.88e-09970416310179
Pubmed

A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary.

DAZ4 DAZ1 DAZ3 DAZ2

1.88e-09970426378784
Pubmed

Embryoid bodies from mouse stem cells express oxytocin receptor, Oct-4 and DAZL.

DAZ4 DAZ1 DAZ3 DAZ2

1.88e-09970419695304
Pubmed

The epigenetic modifications and the anterior to posterior characterization of meiotic entry during mouse oogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

1.88e-09970428235998
Pubmed

Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

1.88e-09970420159962
Pubmed

Maternal DNA Methylation Regulates Early Trophoblast Development.

DAZ4 DAZ1 PCDH12 DAZ3 DAZ2

2.71e-092870526812015
Pubmed

Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

3.13e-091070431234534
Pubmed

Tesmin transcription is regulated differently during male and female meiosis.

DAZ4 DAZ1 DAZ3 DAZ2

3.13e-091070414648882
Pubmed

MAX controls meiotic entry in sexually undifferentiated germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

3.13e-091070438433229
Pubmed

SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.

DAZ4 DAZ1 DAZ3 DAZ2

3.13e-091070423810942
Pubmed

The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence.

DAZ4 DAZ1 DAZ3 DAZ2

3.13e-091070412837688
Pubmed

Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype.

DAZ4 DAZ1 DAZ3 DAZ2

3.13e-091070410601091
CytobandYq11.223

DAZ4 DAZ1 DAZ3 DAZ2

1.31e-0593704Yq11.223
GeneFamilyZona pellucida glycoproteins

ZP1 ZP2

5.23e-0545428
GeneFamilyRNA binding motif containing

DAZ4 RBPMS2 DAZ1 DAZ3 DAZ2

4.28e-04213545725
GeneFamilyHOXL subclass homeoboxes

HOXA11 HOXD3 EVX2

5.02e-0452543518
GeneFamilyCD molecules|Mucins

MUC12 MUC6

1.77e-0321542648
CoexpressionTESAR_JAK_TARGETS_MOUSE_ES_D3_DN

DAZ4 DAZ1 DAZ3 DAZ2

2.14e-0812694MM742
CoexpressionSASAI_TARGETS_OF_CXCR6_AND_PTCH1_DN

DAZ4 DAZ1 DAZ3 DAZ2

2.14e-0812694MM781
CoexpressionWAGSCHAL_EHMT2_TARGETS_UP

DAZ4 DAZ1 DAZ3 DAZ2

3.75e-0723694MM1293
CoexpressionMATZUK_SPERMATOGONIA

DAZ4 DAZ1 DAZ3 DAZ2

1.31e-0631694MM765
CoexpressionCHEN_ETV5_TARGETS_TESTIS

DAZ4 DAZ1 DAZ3 DAZ2

1.70e-0633694MM701
CoexpressionAtlaskidney_P1_CapMes_Crym_top-relative-expression-ranked_100

HOXA11 MET DCX SHISA3

4.15e-0562664gudmap_kidney_P1_CapMes_Crym_100
CoexpressionAtlaskidney_P0_CapMes_Crym_top-relative-expression-ranked_200

MYC HOXA11 MET DCX SHISA3

4.21e-05124665gudmap_kidney_P0_CapMes_Crym_200
Drugdesmethylazelastine

CYP1A1 DAZ4 DAZ1 DAZ3 DAZ2

9.39e-1016695CID000162558
Drugboron trichloride

DAZ4 DAZ1 DAZ3 DAZ2

1.15e-096694CID000025135
Drugd-gluconhydroximo-1,5-lactam

MET DAZ4 DAZ1 DAZ3 DAZ2

3.53e-0831695CID000003479
Drugdazmegrel

DAZ4 DAZ1 DAZ3 DAZ2

2.89e-0719694CID000053555
DrugYM 026

DAZ4 DAZ1 DAZ3 DAZ2

2.89e-0719694CID000004443
DrugAZFd

DAZ4 DAZ1 DAZ3 DAZ2

6.55e-0723694CID000196489
Drugdansylaziridine

DAZ4 DAZ1 DAZ3 DAZ2

6.55e-0723694CID000104008
DrugVistar

DAZ4 DAZ1 DAZ3 DAZ2

4.23e-0636694CID000040896
Drug3-bromo-7-nitroindazole

DAZ4 DAZ1 DAZ3 DAZ2

4.23e-0636694CID000001649
Drugmolybdenum disulfide

DAZ4 DAZ1 DAZ3 DAZ2

8.72e-0643694CID000014823
Drug2-chlorodideoxyadenosine

DAZ4 DAZ1 DAZ3 DAZ2

8.72e-0643694CID000072194
Drug2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide

MYC NOTCH1

9.05e-062692ctd:C576532
Drugpropham

DAZ4 DAZ1 DAZ3 DAZ2

9.57e-0644694CID000024685
Drugridogrel

DAZ4 DAZ1 DAZ3 DAZ2

1.87e-0552694CID005362391
DrugPempidine tartrate [546-48-5]; Down 200; 13uM; PC3; HT_HG-U133A

MET SPTLC2 GATA3 PCNX1 ZFR R3HDM1

2.42e-051906964307_DN
Drugazafagomine

DAZ4 DAZ1 DAZ3 DAZ2

2.70e-0557694CID011957435
DrugOleandomycin phosphate [7060-74-4]; Down 200; 5uM; PC3; HT_HG-U133A

MET ATXN2 SPTLC2 BTBD7 NUP210 FOXJ3

3.14e-051996964615_DN
DrugNSC56408

DAZ4 DAZ1 DAZ3 DAZ2

3.77e-0562694CID000005604
Drugkt S

DAZ4 DAZ1 DAZ3 DAZ2

4.83e-0566694CID006399216
Drugdibromoacetonitrile

MYC MET

5.41e-054692ctd:C051715
Drugazelastine

DAZ4 DAZ1 DAZ3 DAZ2

7.57e-0574694CID000002267
Drugp11-13

DAZ4 DAZ1 DAZ3 DAZ2

7.98e-0575694CID000015759
DiseaseMale sterility due to Y-chromosome deletions

DAZ4 DAZ1 DAZ3 DAZ2

1.79e-098684C2931163
DiseasePartial chromosome Y deletion

DAZ4 DAZ1 DAZ3 DAZ2

1.79e-098684C1507149
DiseaseSpermatogenic Failure, Nonobstructive, Y-Linked

DAZ1 DAZ3 DAZ2

6.42e-0616683C1839071
DiseaseSPERMATOGENIC FAILURE, Y-LINKED, 2

DAZ1 DAZ3 DAZ2

6.42e-0616683415000
DiseaseSpermatogenic failure, Y-linked, 2

DAZ1 DAZ3 DAZ2

6.42e-0616683cv:C1839071
DiseaseOOCYTE MATURATION DEFECT 1

ZP1 ZP2

1.57e-053682C4014291
DiseaseOOCYTE MATURATION DEFECT 3

ZP1 ZP2

1.57e-053682C4540205
DiseaseNeuroblastoma

MYC MET GATA3

1.77e-0447683C0027819
DiseaseConnective Tissue Diseases

ZNF469 NOTCH1

4.02e-0413682C0009782
Diseasecholangiocarcinoma (is_marker_for)

MET MUC6 NOTCH1

4.41e-0464683DOID:4947 (is_marker_for)
Diseasecardiotoxicity, response to anthracycline-based chemotherapy

PRUNE2 SHISA3

4.68e-0414682EFO_0005257, EFO_1001482
Diseaserenal cell carcinoma (biomarker_via_orthology)

MYC CYP1A1

4.68e-0414682DOID:4450 (biomarker_via_orthology)
DiseaseInherited oocyte maturation defect

ZP1 ZP2

6.15e-0416682cv:CN238505
Diseasethyroid peroxidase antibody measurement

DPP9 ATXN2 HLA-DPA1

6.23e-0472683EFO_0005666
DiseaseGlioblastoma

MYC MET NOTCH1

8.17e-0479683C0017636
Diseaseunipolar depression, response to bupropion, mood disorder

HCN1 NAV3

8.72e-0419682EFO_0003761, EFO_0004247, EFO_0006326
Diseasetemporal lobe epilepsy (is_marker_for)

HCN1 DCX

9.68e-0420682DOID:3328 (is_marker_for)
DiseaseGiant Cell Glioblastoma

MYC MET NOTCH1

9.76e-0484683C0334588
Diseaseretinal vasculature measurement

ATXN2 ZNF804B NAV3 OSBPL8 MUC12 R3HDM1

1.23e-03517686EFO_0010554
DiseaseCerebral Astrocytoma

MET NOTCH1

1.52e-0325682C0750935
DiseaseIntracranial Astrocytoma

MET NOTCH1

1.52e-0325682C0750936
DiseasePilocytic Astrocytoma

MET NOTCH1

1.52e-0325682C0334583
DiseaseAstrocytoma

MET NOTCH1

1.52e-0325682C0004114
DiseaseJuvenile Pilocytic Astrocytoma

MET NOTCH1

1.52e-0325682C0280783
DiseaseDiffuse Astrocytoma

MET NOTCH1

1.52e-0325682C0280785
DiseaseGrade I Astrocytoma

MET NOTCH1

1.52e-0325682C1704230
DiseaseSubependymal Giant Cell Astrocytoma

MET NOTCH1

1.52e-0325682C0205768
DiseaseMixed oligoastrocytoma

MET NOTCH1

1.52e-0325682C0547065
DiseaseChildhood Cerebral Astrocytoma

MET NOTCH1

1.52e-0325682C0338070
DiseaseGemistocytic astrocytoma

MET NOTCH1

1.64e-0326682C0334581
DiseaseProtoplasmic astrocytoma

MET NOTCH1

1.64e-0326682C0334580
DiseaseFibrillary Astrocytoma

MET NOTCH1

1.64e-0326682C0334582
Diseasesodium measurement

CYP1A1 BTBD7 MAST2

1.76e-03103683EFO_0009282
Diseaseeye measurement

ZNF469 ATXN2

1.77e-0327682EFO_0004731
DiseaseAnaplastic astrocytoma

MET NOTCH1

1.77e-0327682C0334579
Diseaseoral squamous cell carcinoma (is_implicated_in)

CYP1A1 BARHL2

1.90e-0328682DOID:0050866 (is_implicated_in)
Diseaserespiratory failure, COVID-19

DPP9 HLA-DPA1

2.04e-0329682EFO_0009686, MONDO_0100096
DiseaseGlioblastoma Multiforme

MYC MET NOTCH1

2.17e-03111683C1621958

Protein segments in the cluster

PeptideGeneStartEntry
SHSSISITFSHYPPA

C8orf86

131

Q6ZUL3
SHIYTFPHASFSEPL

BTN3A3

481

O00478
THAAATGSLPYPFHS

EVX2

266

Q03828
HVSTYAAFVQTHRPT

HLA-DPA1

36

P20036
VTQHVQAYSAYPHSP

DAZ2

161

Q13117
VTQHVQAYSAYPHSP

DAZ3

161

Q9NR90
PSHSESQATPHSSYG

CCDC14

241

Q49A88
SSHGAPVVYPTVSTH

R3HDM1

436

Q15032
TPAISHAAFTYPTAT

RBPMS2

166

Q6ZRY4
FRHSSFVPFTIPHST

CYP1A1

376

P04798
PNTLHTYTLSPSEHF

PCDH12

166

Q9NPG4
HSPHYFAASSPTSPN

NUP210

1851

Q8TEM1
SFHATTTYPTPSHPE

MUC6

1426

Q6W4X9
RFPSHFVHPTCSSYS

LETM2

16

Q2VYF4
PKSTEYTFFSAPHHT

nan

186

O00370
LSSPATETVHHSPAY

LRCH3

581

Q96II8
TETVHHSPAYSFPAA

LRCH3

586

Q96II8
SQHSYSSPVDNTPSH

NOTCH1

2486

P46531
PGSVSTHHSSPRSDY

MAGI2

876

Q86UL8
NPPQIHHFSSSFYSD

FAM149A

531

A5PLN7
VSTTAHFPYMTHPSV

ATXN2

1291

Q99700
GTTEYHPFTLTSAPH

DUOX2

1311

Q9NRD8
VYSGHPVQHISFSSH

FBXW8

511

Q8N3Y1
YPPTLGTSHSSHSVQ

PCNX1

2096

Q96RV3
QHSHPNTATVAPFIY

NAV3

621

Q8IVL0
TNETPPLFHSYSENH

KIF24

801

Q5T7B8
RPPSSSHTVSIFHYQ

MPZL3

71

Q6UWV2
VAYYSPTTRHSVSHP

KIAA1549L

521

Q6ZVL6
PHPTYTDLSAHHSSQ

HOXD3

406

P31249
SANVYHHPTPAVSSN

HOXA11

111

P31270
HHPTPAVSSNFYSTV

HOXA11

116

P31270
APVLFTYIHHASGTS

OR12D1

246

P0DN82
QVSHHPPISAFYVSN

OSBPL8

511

Q9BZF1
ASSSTHHPITTYPPY

GATA3

211

P23771
YSIPPHDTQYTVFHS

GAK

276

O14976
PVYTATSLSHSNLHS

HCN1

666

O60741
KHAASPSTYSPTHNA

CC2D2A

1076

Q9P2K1
VTQHVQAYSAYPHSP

DAZ1

491

Q9NQZ3
SHYSSVSTPPCVHVY

DPP9

561

Q86TI2
GSVHSYTPVTSHPES

FOXJ3

246

Q9UPW0
GAFSTEQSHYPPHSV

NCOR1P1

11

Q9H4R4
SSRYSPSQNSPIHHI

BCLAF1

281

Q9NYF8
LPSPTHSAHCSFYRT

DCX

26

O43602
YATTDTHQPVAIHPS

DHX33

641

Q9H6R0
SFTFSFHSPPHTAAH

ADGRG1

156

Q9Y653
ATFPNSFPSHTEHST

CCP110

121

O43303
SQHPSRSFSYPCNHS

BTBD7

786

Q9P203
ACAPYSTSVSSPHHT

BARHL2

156

Q9NY43
THSHSLSPRSPTQGY

MAST2

1266

Q6P0Q8
SVHLSVHSYFTVPDT

DENND1A

146

Q8TEH3
VTQHVQAYSAYPHSP

DAZ4

326

Q86SG3
INSSYFPDHPLHSIS

MET

201

P08581
SEIFPVTHSFPSSAH

RAB11FIP1

1101

Q6WKZ4
THYTNPFSDNHQSPF

PRUNE2

1881

Q8WUY3
HVSTHQHNYAAPPST

MYC

301

P01106
TTLHETPTTGNHYPS

PLPP1

266

O14494
YTTSHSIHLAQPSGF

SHISA3

196

A0PJX4
PCSSQPVATHAYSSH

STARD9

2956

Q9P2P6
PSHHLSFKYPFSSTS

PLAG1

326

Q6DJT9
PYVHVTSSSVPFNET

UBA6

131

A0AVT1
SAPSTHSHAYTQHPG

ZNF532

881

Q9HCE3
HPLSQAHFSPISFST

ZNF804B

1236

A4D1E1
YTSHAHELSAPSVHP

LINC00052

106

Q96N35
HLAYAPTSCSPTQHT

ZP1

306

P60852
HSHSAVYATSLSPPV

SPTLC2

401

O15270
THFASQNQHSYSSPP

TFDP3

81

Q5H9I0
PYPTHHFSLSSASLD

ZNF469

711

Q96JG9
FCSSSHPIQHPGTYV

ZNF658

421

Q5TYW1
SHPTTVASYTVHQAP

ZFR

56

Q96KR1
SHQHHPVTPVSTVYS

TRIM50

116

Q86XT4
TFHPVGSSVTHPDHY

ZP2

576

Q05996
SHFSVLSFTPSPQDH

SIGLEC16

196

A6NMB1
FCSSSHPIQHPGTYV

ZNF658B

181

Q4V348
TTYHSSPSSTPTTHF

MUC12

446

Q9UKN1
TYHSSPGSTQTMHFP

MUC12

831

Q9UKN1
TYHSRPSSTPTTHFS

MUC12

3166

Q9UKN1
TYHSSPGSTQTMHFP

MUC12

3471

Q9UKN1
YHSSPGSIATTHFPE

MUC12

4801

Q9UKN1