Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	methionine adenosyltransferase activity	MAT1A MAT2A	8.01e-06	2	57	2	GO:0004478
GeneOntologyMolecularFunction	proteasome-activating activity	PSMC1 PSMC4	1.19e-04	6	57	2	GO:0036402
GeneOntologyCellularComponent	methionine adenosyltransferase complex	MAT1A MAT2A	2.19e-05	3	57	2	GO:0048269
GeneOntologyCellularComponent	proteasome regulatory particle, base subcomplex	PSMC1 PSMC4	4.74e-04	12	57	2	GO:0008540
Domain	EamA_dom	SLC35G3 SLC35G5 SLC35G6 SLC35G4	7.63e-08	14	57	4	IPR000620
Domain	EamA	SLC35G3 SLC35G5 SLC35G6 SLC35G4	7.63e-08	14	57	4	PF00892
Domain	S-AdoMet_synt_M	MAT1A MAT2A	9.15e-06	2	57	2	PF02772
Domain	S-AdoMet_synt_C	MAT1A MAT2A	9.15e-06	2	57	2	PF02773
Domain	ADOMET_SYNTHASE_CS	MAT1A MAT2A	9.15e-06	2	57	2	IPR022631
Domain	S-AdoMet_synt_C	MAT1A MAT2A	9.15e-06	2	57	2	IPR022630
Domain	S-AdoMet_synthetase_sfam	MAT1A MAT2A	9.15e-06	2	57	2	IPR022636
Domain	S-AdoMet_synt_N	MAT1A MAT2A	9.15e-06	2	57	2	PF00438
Domain	S-AdoMet_synt_central	MAT1A MAT2A	9.15e-06	2	57	2	IPR022629
Domain	S-AdoMet_synt_N	MAT1A MAT2A	9.15e-06	2	57	2	IPR022628
Domain	S-AdoMet_synthetase	MAT1A MAT2A	9.15e-06	2	57	2	IPR002133
Domain	ADOMET_SYNTHASE_1	MAT1A MAT2A	9.15e-06	2	57	2	PS00376
Domain	ADOMET_SYNTHASE_2	MAT1A MAT2A	9.15e-06	2	57	2	PS00377
Domain	26S_Psome_P45	PSMC1 PSMC4	1.36e-04	6	57	2	IPR005937
Domain	Peptidase_M28	NAALAD2 QPCTL	5.92e-04	12	57	2	IPR007484
Domain	Peptidase_M28	NAALAD2 QPCTL	5.92e-04	12	57	2	PF04389
Domain	AAA+_ATPase	MDN1 PSMC1 PSMC4 NUBP1	9.75e-04	144	57	4	IPR003593
Domain	AAA	MDN1 PSMC1 PSMC4 NUBP1	9.75e-04	144	57	4	SM00382
Domain	ATPase_AAA_CS	PSMC1 PSMC4	3.52e-03	29	57	2	IPR003960
Domain	AAA	PSMC1 PSMC4	4.82e-03	34	57	2	PS00674
Domain	AAA	PSMC1 PSMC4	1.10e-02	52	57	2	PF00004
Pathway	KEGG_SELENOAMINO_ACID_METABOLISM	SEPHS2 MAT1A MAT2A	4.87e-05	26	39	3	M7151
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_P21_CELL_CYCLE_G1_S_N00498	CDKN1A E2F2	2.07e-04	8	39	2	M47585
Pathway	WP_METHYLATION_PATHWAYS	MAT1A MAT2A	2.65e-04	9	39	2	M39493
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_P21_CELL_CYCLE_G1_S_N00497	CDKN1A E2F2	2.65e-04	9	39	2	M47584
Pathway	WP_METHYLATION	MAT1A MAT2A	2.65e-04	9	39	2	MM15836
Pathway	KEGG_MEDICUS_REFERENCE_METHIONINE_DEGRADATION	MAT1A MAT2A	3.31e-04	10	39	2	M47939
Pathway	KEGG_MEDICUS_REFERENCE_MDM2_P21_CELL_CYCLE_G1_S_N00536	CDKN1A E2F2	4.04e-04	11	39	2	M47591
Pathway	REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION	CDKN1A PSMC1 PSMC4 E2F2	4.42e-04	130	39	4	MM15146
Pathway	REACTOME_AUF1_HNRNP_D0_BINDS_AND_DESTABILIZES_MRNA	EIF4G1 PSMC1 PSMC4	4.65e-04	55	39	3	MM15137
Pathway	REACTOME_AUF1_HNRNP_D0_BINDS_AND_DESTABILIZES_MRNA	EIF4G1 PSMC1 PSMC4	4.65e-04	55	39	3	M998
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_MDM2_TO_P21_CELL_CYCLE_G1_S	CDKN1A E2F2	4.84e-04	12	39	2	M47417
Pathway	REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES	SEPHS2 NAALAD2 MAT1A PSMC1 PSMC4	5.41e-04	245	39	5	MM15403
Pathway	REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21	CDKN1A PSMC1 PSMC4	5.44e-04	58	39	3	MM14715
Pathway	KEGG_MEDICUS_REFERENCE_MDM2_P21_CELL_CYCLE_G1_S_N00066	CDKN1A E2F2	5.71e-04	13	39	2	M47416
Pathway	REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21	CDKN1A PSMC1 PSMC4	6.01e-04	60	39	3	M1081
Pathway	REACTOME_METHYLATION	MAT1A MAT2A	6.65e-04	14	39	2	MM14596
Pathway	REACTOME_METHYLATION	MAT1A MAT2A	6.65e-04	14	39	2	M26967
Pathway	REACTOME_G1_S_DNA_DAMAGE_CHECKPOINTS	CDKN1A PSMC1 PSMC4	7.26e-04	64	39	3	MM15386
Pathway	REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION	CDKN1A PSMC1 PSMC4 E2F2	7.39e-04	149	39	4	M848
Pathway	SA_G1_AND_S_PHASES	CDKN1A E2F2	7.65e-04	15	39	2	M1529
Pathway	KEGG_MEDICUS_REFERENCE_P300_P21_CELL_CYCLE_G1_S	CDKN1A E2F2	7.65e-04	15	39	2	M47524
Pathway	REACTOME_REGULATION_OF_RAS_BY_GAPS	RASAL3 PSMC1 PSMC4	7.94e-04	66	39	3	MM15261
Pathway	REACTOME_REGULATION_OF_RAS_BY_GAPS	RASAL3 PSMC1 PSMC4	8.66e-04	68	39	3	M27539
Pathway	REACTOME_G1_S_DNA_DAMAGE_CHECKPOINTS	CDKN1A PSMC1 PSMC4	8.66e-04	68	39	3	M27672
Pathway	REACTOME_CYCLIN_A_CDK2_ASSOCIATED_EVENTS_AT_S_PHASE_ENTRY	CDKN1A PSMC1 PSMC4	9.43e-04	70	39	3	MM15389
Pathway	REACTOME_ABERRANT_REGULATION_OF_MITOTIC_G1_S_TRANSITION_IN_CANCER_DUE_TO_RB1_DEFECTS	CDKN1A E2F2	9.88e-04	17	39	2	M38998
Pathway	REACTOME_THE_ROLE_OF_GTSE1_IN_G2_M_PROGRESSION_AFTER_G2_CHECKPOINT	CDKN1A PSMC1 PSMC4	1.07e-03	73	39	3	MM15491
Pathway	REACTOME_THE_ROLE_OF_GTSE1_IN_G2_M_PROGRESSION_AFTER_G2_CHECKPOINT	CDKN1A PSMC1 PSMC4	1.34e-03	79	39	3	M27743
Pathway	REACTOME_MITOTIC_G2_G2_M_PHASES	CDKN1A TPX2 PSMC1 PSMC4	1.62e-03	184	39	4	MM15145
Pathway	REACTOME_CYCLIN_A_CDK2_ASSOCIATED_EVENTS_AT_S_PHASE_ENTRY	CDKN1A PSMC1 PSMC4	1.65e-03	85	39	3	M27674
Pathway	WP_METHIONINE_DE_NOVO_AND_SALVAGE_PATHWAY	MAT1A MAT2A	1.66e-03	22	39	2	M39367
Pathway	REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS	EIF4G1 PSMC1 PSMC4	1.71e-03	86	39	3	MM15140
Pathway	REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS	EIF4G1 PSMC1 PSMC4	1.77e-03	87	39	3	M944
Pathway	REACTOME_MITOTIC_G2_G2_M_PHASES	CDKN1A TPX2 PSMC1 PSMC4	2.19e-03	200	39	4	M864
Pathway	REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES	FANCE EIF4G1 DHX9	2.21e-03	94	39	3	MM14515
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3	CDKN1A PSMC1 PSMC4	2.34e-03	96	39	3	M27784
Pubmed	RT-PCR of fatty acid elongases.	SLC35G3 SLC35G5 SLC35G6 SLC35G4	6.96e-12	4	58	4	9056918
Pubmed	Emergence of primate genes by retrotransposon-mediated sequence transduction.	SLC35G3 SLC35G5 SLC35G6 SLC35G4	6.96e-12	4	58	4	17101974
Pubmed	Defining the membrane proteome of NK cells.	NRM MDN1 RASAL3 QPCTL ATP11B MPDU1 EIF4G1 PSMC1 PSMC4 PEX14 MED12 DHX9	4.17e-07	1168	58	12	19946888
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	CDKN1A FANCE MDN1 TCF20 TPX2 PSMC1 PSMC4 MED12	8.44e-07	453	58	8	29656893
Pubmed	Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.	MAT1A MAT2A	2.73e-06	2	58	2	22318685
Pubmed	S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.	MAT1A MAT2A	2.73e-06	2	58	2	27076759
Pubmed	A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.	MAT1A MAT2A	2.73e-06	2	58	2	29749642
Pubmed	Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.	MAT1A MAT2A	2.73e-06	2	58	2	31234428
Pubmed	Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.	MAT1A MAT2A	2.73e-06	2	58	2	29448301
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CDKN1A NRM MAGED1 TCF20 QPCTL MICAL2 MPDU1 EIF4G1 LOXL4 MED12 DHX9	4.15e-06	1203	58	11	29180619
Pubmed	Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.	MAT1A MAT2A	8.19e-06	3	58	2	23425511
Pubmed	Accelerated DNA replication in E2F1- and E2F2-deficient macrophages leads to induction of the DNA damage response and p21(CIP1)-dependent senescence.	CDKN1A E2F2	8.19e-06	3	58	2	20676136
Pubmed	Multiple species of mammalian S-adenosylmethionine synthetase. Partial purification and characterization.	MAT1A MAT2A	8.19e-06	3	58	2	7213623
Pubmed	Structure and function study of the complex that synthesizes S-adenosylmethionine.	MAT1A MAT2A	8.19e-06	3	58	2	25075345
Pubmed	Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition†.	MAT1A MAT2A	8.19e-06	3	58	2	30265288
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MDN1 TCF20 SBF1 SPR MICAL2 MAT2A EIF4G1 PSMC1 PSMC4 MED12 DHX9	1.26e-05	1353	58	11	29467282
Pubmed	E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution.	CDKN1A E2F2	1.64e-05	4	58	2	25656653
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DCHS2 TRANK1 MDN1 QPCTL CAPN7 PSMC4 MED12	1.87e-05	497	58	7	36774506
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	MDN1 SPR EIF4G1 TPX2 PSMC1 PSMC4	1.93e-05	332	58	6	32786267
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	MAGED1 EIF4G1 PSMC1 DHX9	2.52e-05	101	58	4	26949739
Pubmed	Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation.	CDKN1A E2F2	2.72e-05	5	58	2	17008321
Pubmed	Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.	CDKN1A FANCE	2.72e-05	5	58	2	19704162
Pubmed	USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates.	CDKN1A USP21	4.08e-05	6	58	2	34425107
Pubmed	ASK1 negatively regulates the 26 S proteasome.	PSMC1 PSMC4	4.08e-05	6	58	2	20843792
Pubmed	Cancer vulnerabilities unveiled by genomic loss.	PSMC1 PSMC4	4.08e-05	6	58	2	22901813
Pubmed	Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases.	PSMC1 PSMC4	4.08e-05	6	58	2	9473509
Pubmed	Structure of the human 26S proteasome at a resolution of 3.9 Å.	PSMC1 PSMC4	5.71e-05	7	58	2	27342858
Pubmed	Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking.	PSMC1 PSMC4	5.71e-05	7	58	2	11361004
Pubmed	C termini of proteasomal ATPases play nonequivalent roles in cellular assembly of mammalian 26 S proteasome.	PSMC1 PSMC4	7.60e-05	8	58	2	21628461
Pubmed	Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.	MAT1A MAT2A	7.60e-05	8	58	2	19158324
Pubmed	ATP binding by proteasomal ATPases regulates cellular assembly and substrate-induced functions of the 26 S proteasome.	PSMC1 PSMC4	7.60e-05	8	58	2	23212908
Pubmed	Parkin directly modulates 26S proteasome activity.	PSMC1 PSMC4	9.77e-05	9	58	2	20810900
Pubmed	Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis.	CDKN1A TPX2	9.77e-05	9	58	2	38605277
Pubmed	Reactivity of anti-proliferating cell nuclear antigen (PCNA) murine monoclonal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation.	CDKN1A DHX9	9.77e-05	9	58	2	11254741
Pubmed	Identification of DNA replication and cell cycle proteins that interact with PCNA.	CDKN1A DHX9	9.77e-05	9	58	2	9396813
Pubmed	Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling.	CDKN1A E2F2	1.22e-04	10	58	2	26449752
Pubmed	Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases.	PSMC1 PSMC4	1.22e-04	10	58	2	15831487
Pubmed	LINC00152 Promotes Tumor Progression and Predicts Poor Prognosis by Stabilizing BCL6 From Degradation in the Epithelial Ovarian Cancer.	EIF4G1 DHX9	1.22e-04	10	58	2	33282727
Pubmed	Stable incorporation of ATPase subunits into 19 S regulatory particle of human proteasome requires nucleotide binding and C-terminal tails.	PSMC1 PSMC4	1.49e-04	11	58	2	22275368
Pubmed	Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development.	CDKN1A TG	1.49e-04	11	58	2	21364918
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	ARHGAP32 MAT2A EIF4G1 PSMC1 PSMC4 MED12 DHX9	1.72e-04	708	58	7	39231216
Pubmed	Proteasome involvement in the repair of DNA double-strand breaks.	PSMC1 PSMC4	1.78e-04	12	58	2	15610744
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	CDKN1A MAGED1 QPCTL MAT2A EIF4G1 PSMC1 PSMC4 DHX9	2.00e-04	971	58	8	33306668
Pubmed	Induction of cell cycle entry and cell death in postmitotic lens fiber cells by overexpression of E2F1 or E2F2.	CDKN1A E2F2	2.11e-04	13	58	2	11095619
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	MDN1 MAGED1 QPCTL MAT2A EIF4G1 PSMC1 PSMC4 MED12 DHX9	2.21e-04	1257	58	9	37317656
Pubmed	Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.	MAGED1 PSMC1 PSMC4	2.23e-04	70	58	3	21726808
Pubmed	Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.	CDKN1A E2F2	2.46e-04	14	58	2	9190208
Pubmed	USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.	PSMC1 PSMC4	2.46e-04	14	58	2	27880911
Pubmed	CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase.	PSMC1 PSMC4	3.23e-04	16	58	2	29979702
Pubmed	C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice.	CDKN1A E2F2	3.23e-04	16	58	2	10082561
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	QPCTL MAT2A PSMC1 PSMC4 DHX9	4.48e-04	383	58	5	29331416
Pubmed	Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.	CDKN1A FANCE SLC35G6	4.51e-04	89	58	3	18950845
Pubmed	Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.	PSMC1 PSMC4	4.59e-04	19	58	2	19490896
Pubmed	UBASH3A Regulates the Synthesis and Dynamics of TCR-CD3 Complexes.	PSMC1 PSMC4	5.09e-04	20	58	2	31659016
Pubmed	Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity.	CAPN7 PSMC1 PSMC4	5.63e-04	96	58	3	34599178
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	MAT2A EIF4G1 PSMC1 NUBP1 DHX9	6.16e-04	411	58	5	36652389
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	EIF4G1 PSMC1 PSMC4 LOXL4 DHX9	6.65e-04	418	58	5	35338135
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	MDN1 MAT2A EIF4G1 PSMC1 PSMC4 DHX9	6.71e-04	638	58	6	33239621
Pubmed	Phosphatase UBLCP1 controls proteasome assembly.	PSMC1 PSMC4	7.37e-04	24	58	2	28539385
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ARHGAP32 MAGED1 RASAL3 TPX2 PEX14	7.55e-04	430	58	5	35044719
Pubmed	Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.	CDKN1A E2F2	8.00e-04	25	58	2	20696915
Pubmed	La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).	MAGED1 EIF4G1 PSMC4	8.37e-04	110	58	3	25940091
Pubmed	Tissue-specific regulation of retinal and pituitary precursor cell proliferation.	CDKN1A VAX1	8.66e-04	26	58	2	12130660
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	RASAL3 DCAF12L1 SLC35G3 SLC35G5 SLC35G6 SLC35G4	8.91e-04	674	58	6	37196079
Pubmed	A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.	PSMC1 PSMC4	9.34e-04	27	58	2	16990800
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	NRM MAGED1 QPCTL SARM1 EIF4G1 PSMC1 PSMC4	9.45e-04	942	58	7	31073040
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	MAGED1 PSMC1 PSMC4 DHX9	9.98e-04	264	58	4	32814769
Pubmed	Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.	EIF4G1 PSMC1 PSMC4 DHX9	1.07e-03	269	58	4	30442662
Pubmed	Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle.	CDKN1A E2F2	1.08e-03	29	58	2	34246625
Pubmed	Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.	MAT1A MAT2A	1.08e-03	29	58	2	19048631
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	MAT2A PSMC1 PSMC4 PEX14 TBCEL DHX9	1.12e-03	704	58	6	32994395
Pubmed	USP14 is a deubiquitinase for Ku70 and critical determinant of non-homologous end joining repair in autophagy and PTEN-deficient cells.	PSMC1 PSMC4	1.15e-03	30	58	2	31740976
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	MAGED1 MAT2A EIF4G1 PSMC1 PSMC4 DHX9	1.20e-03	714	58	6	28302793
Pubmed	Dynamic Interaction of USP14 with the Chaperone HSC70 Mediates Crosstalk between the Proteasome, ER Signaling, and Autophagy.	PSMC1 PSMC4	1.23e-03	31	58	2	31901637
Pubmed	Physiological and pathophysiological characteristics of ataxin-3 isoforms.	MAGED1 EIF4G1 PSMC1 PSMC4	1.26e-03	281	58	4	30455355
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	MDN1 MAGED1 MAT2A EIF4G1 PSMC4 DHX9	1.30e-03	725	58	6	27025967
Pubmed	Anchoring of the 26S proteasome to the organellar membrane by FKBP38.	PSMC1 PSMC4	1.31e-03	32	58	2	17573772
Pubmed	ROR2 Downregulation Activates the MSX2/NSUN2/p21 Regulatory Axis and Promotes Dental Pulp Stem Cell Senescence.	CDKN1A EIF4G1 DHX9	1.39e-03	131	58	3	35356984
Pubmed	Liver and brain differential expression of one-carbon metabolism genes during ontogenesis.	MAT1A MAT2A	1.40e-03	33	58	2	34702858
Pubmed	Recognition and processing of ubiquitin-protein conjugates by the proteasome.	PSMC1 PSMC4	1.40e-03	33	58	2	19489727
Pubmed	Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome.	PSMC1 PSMC4	1.40e-03	33	58	2	29636472
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	EIF4G1 TPX2 PSMC1 PSMC4 DHX9	1.40e-03	494	58	5	26831064
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	MDN1 TCF20 MAT2A EIF4G1 TPX2 MED12 DHX9	1.45e-03	1014	58	7	32416067
Pubmed	An atomic structure of the human 26S proteasome.	PSMC1 PSMC4	1.48e-03	34	58	2	27428775
Pubmed	MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.	CDKN1A MED12	1.48e-03	34	58	2	15989967
Pubmed	Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma.	PSMC1 PSMC4	1.48e-03	34	58	2	32842143
Pubmed	Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.	MAGED1 EIF4G1	1.48e-03	34	58	2	16611982
Pubmed	Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome.	PSMC1 PSMC4	1.57e-03	35	58	2	30257870
Pubmed	Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells.	CDKN1A TPX2	1.57e-03	35	58	2	37269288
Pubmed	Mapping the murine cardiac 26S proteasome complexes.	PSMC1 PSMC4	1.57e-03	35	58	2	16857966
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	MAGED1 QPCTL MAT2A EIF4G1 PSMC1 PSMC4 PANX3 DHX9	1.61e-03	1335	58	8	29229926
Pubmed	Proteomic analysis of the NOS2 interactome in human airway epithelial cells.	QPCTL PSMC1 PSMC4	1.61e-03	138	58	3	23438482
Interaction	NANOG interactions	MDN1 MAGED1 TCF20 TPX2 PSMC1 PSMC4 MED12 DHX9 USP21	5.59e-06	481	55	9	int:NANOG
Cytoband	3q27	ATP11B EIF4G1	4.62e-04	25	58	2	3q27
GeneFamily	AAA ATPases	MDN1 PSMC1 PSMC4	1.72e-04	53	37	3	413
GeneFamily	Solute carriers	SLC29A3 SLC35G3 SLC35G5 SLC35G6 SLC35G4	1.19e-03	395	37	5	752
GeneFamily	Proteasome	PSMC1 PSMC4	3.49e-03	43	37	2	690
Drug	DNP-Cap	SPR TG	5.94e-06	2	56	2	CID000096812
Drug	2-amino-4-methylthio-3-butenoic acid	MAT1A MAT2A	5.94e-06	2	56	2	ctd:C083253
Drug	ICI182,780; Down 200; 1uM; PC3; HT_HG-U133A	SBF1 MPDU1 PAFAH1B2 SARM1 C2orf42 PEX14	9.07e-06	198	56	6	7096_DN
Drug	L-2-amino-4-methylthio-cis-but-3-enoic acid	MAT1A MAT2A	1.78e-05	3	56	2	CID006439623
Drug	benzylphosphate	MAT1A MAT2A	1.78e-05	3	56	2	CID000074359
Drug	UF010 compound	CDKN1A PEX14 E2F2	3.12e-05	25	56	3	ctd:C000602704
Drug	NSC-187732	MAT1A MAT2A	3.55e-05	4	56	2	CID000302526
Drug	vinthionine	MAT1A MAT2A	3.55e-05	4	56	2	CID000055145
Drug	seleno-DL-ethionine	MAT1A MAT2A	3.55e-05	4	56	2	CID000145924
Disease	asymmetrical dimethylarginine measurement	LOXL4 NANOS1	9.14e-05	8	54	2	EFO_0006522
Disease	WNT1-inducible-signaling pathway protein 1 measurement	SARM1 TG	1.47e-04	10	54	2	EFO_0008321
Disease	lipid metabolism disorder (implicated_via_orthology)	MAT1A MAT2A	3.40e-04	15	54	2	DOID:3146 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	DCHS2 NEIL1 PCSK1N MED12	6.52e-04	215	54	4	DOID:9970 (implicated_via_orthology)
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	SARM1 PSMC4	1.38e-03	30	54	2	DOID:332 (implicated_via_orthology)
Disease	hypothyroidism	TRANK1 SBF1 PAFAH1B2 TG	1.82e-03	284	54	4	EFO_0004705

Protein segments in the cluster

Peptide	Gene	Start	Entry
GRIEKQPVLRPLELK	C2orf42	486	Q9NWW7
ERVRGLGLPKLYLPT	CDKN1A	66	P38936
LPRGKVPLREERLDG	ARID3C	341	A6NKF2
KLRALRRPGGVLEKP	CCDC154	636	A6NI56
KLVLLGGEEEGPRRP	RASAL3	146	Q86YV0
ELPLGRELRVPLIGS	QPCTL	61	Q9NXS2
VPLLGRVPLDPLIGK	NUBP1	261	P53384
PQGRRLEEVRLKPIL	LOXL4	151	Q96JB6
PSGLEGELLRRLPKL	MDN1	4046	Q9NU22
LRPGVRHPLLGDLRK	MAGED1	591	Q9Y5V3
RRLLGLRGEPPELDL	MAG	581	P20916
ARGKELRLILSPLPG	NEIL1	51	Q96FI4
RPGVIVRDLDLKKPI	MAT2A	356	P31153
ILKGPDGRVLCPVLR	NANOS1	231	Q8WY41
PPEGVLGALLRVKRL	PCSK1N	231	Q9UHG2
KRPPGFLGLLRLIRE	PNMA6E	476	A0A0J9YXQ4
RPGVIVRDLDLKKPI	MAT1A	356	Q00266
RPGEDELLKLLLPLL	MED12	266	Q93074
GLGEPLALKSPRALR	NRM	176	Q8IXM6
LSPKIDRDLREGGPL	P3H2	431	Q8IVL5
GLPEKVRDGARVPLL	ARHGAP32	1381	A7KAX9
QKPKLLRPRLLPGEE	SBF1	881	O95248
RAPVGKLLLLPGRRD	DCHS2	16	Q6V1P9
LLPDRRGPRLKGLRL	PANX3	16	Q96QZ0
RGPRLKGLRLELPLD	PANX3	21	Q96QZ0
KRKLDLEGIGRPVVP	E2F2	86	Q14209
IEKTGPLLIELRGPR	CAPN7	721	Q9Y6W3
DIILSLIGELPPIRK	CPLANE1	1346	Q9H799
IPPKRGELKTELLGL	BRAWNIN	41	Q69YU5
GELFREITKPLRPLG	EIF4G1	1356	Q04637
PGSLIPEALRLLRLG	HCFC1R1	106	Q9NWW0
ADGEGPLLLKRQRRP	DCAF12L1	31	Q5VU92
GPDGRLELKPLLLRL	FANCE	76	Q9HB96
LLVRKRLLGLEPEGP	FHIP2A	716	Q5W0V3
LGRILAKLPIEPRFG	DHX9	851	Q08211
RGGRVLKPVRPLLLP	MICAL2	1481	O94851
LKPVRPLLLPRAAGE	MICAL2	1486	O94851
VLGLLPRGEKPNPLR	PAFAH1B2	136	P68402
LLEKLLDRPPPGLQR	SLC29A3	31	Q9BZD2
LLKLRGDPLLGPPDI	SLC35G5	86	Q96KT7
LLKLRGDPLLGTPDI	SLC35G3	86	Q8N808
LLRPGRLDRKIEFPL	PSMC4	321	P43686
GPLLKLLPLDARDRG	SPATA5L1	11	Q9BVQ7
IRLPDRPLKPGEVLS	TMEM132E	296	Q6IEE7
LIRPGRIDRKIEFPL	PSMC1	341	P62191
LLPLILGGREDRKQL	PEX14	131	O75381
DGPLKRLLVPILLPE	MPDU1	6	O75352
RRALKPVGPLPSLLE	C11orf42	71	Q8N5U0
PLGPESLLLRGARLK	ATP11B	236	Q9Y2G3
LLKLRGDPLLGPPDI	SLC35G4	86	P0C7Q5
KLLAGLTRPDVRPPL	SEPHS2	71	Q99611
PGLPDERLKKLELGR	USP21	56	Q9UK80
KRALRLLGEEVPRPI	SARM1	391	Q6SZW1
GALRELPRPKGLQRL	SPR	81	P35270
ILPPRKGRGLKLEAI	TCF20	1341	Q9UGU0
LLKLRGDPLLGPPDI	SLC35G6	86	P0C7Q6
LLLLTRKVSGEPPLG	TRANK1	401	O15050
KGIRLRNEDLGLPPL	TG	961	P01266
FPKLEEVRLLGIPLL	TBCEL	251	Q5QJ74
IREIILPKGLDLDRP	VAX1	86	Q5SQQ9
ELDPRILEGGPILPK	TPX2	406	Q9ULW0
LERAFIDPLGLPGKL	NAALAD2	661	Q9Y3Q0