Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionfructose 1,6-bisphosphate 1-phosphatase activity

FBP2 FBP1

5.24e-0521452GO:0042132
GeneOntologyMolecularFunctionRab GDP-dissociation inhibitor activity

GDI1 GDI2

5.24e-0521452GO:0005093
GeneOntologyCellularComponentvesicle membrane

MGAM RHOD SYN3 RIPK1 HBEGF APC GRIA3 VPS36 ITGA2B HMOX2 RAB14 CLCN3 TM9SF2 PTPRS SLC18A2 LRP1 GALNTL5 RIPOR1 KIR3DL1 SORL1 EPHA8

2.20e-04132514121GO:0012506
GeneOntologyCellularComponentsomatodendritic compartment

SLC25A27 DPP6 LHFPL4 MYO10 APC GRIA3 GJC2 CLSTN2 GDI1 KCNA4 PTPRS SLC18A2 RPTOR LRP1 USH2A DYNC1H1 CNN3 EPHA3 SORL1 EPHA8

2.21e-04122814120GO:0036477
GeneOntologyCellularComponentcytoplasmic vesicle membrane

MGAM RHOD SYN3 RIPK1 HBEGF APC GRIA3 VPS36 ITGA2B HMOX2 RAB14 CLCN3 TM9SF2 PTPRS SLC18A2 LRP1 GALNTL5 KIR3DL1 SORL1 EPHA8

4.94e-04130714120GO:0030659
GeneOntologyCellularComponentneuronal cell body

SLC25A27 DPP6 MYO10 APC GRIA3 GJC2 GDI1 PTPRS SLC18A2 RPTOR LRP1 USH2A DYNC1H1 CNN3 SORL1

5.27e-0483514115GO:0043025
GeneOntologyCellularComponentfocal adhesion

TNC ITGA2B GDI2 FOCAD JAK1 LRP1 ADAM17 TNS1 CNN1 CNN3

7.01e-0443114110GO:0005925
GeneOntologyCellularComponentcell-substrate junction

TNC ITGA2B GDI2 FOCAD JAK1 LRP1 ADAM17 TNS1 CNN1 CNN3

8.64e-0444314110GO:0030055
GeneOntologyCellularComponentanchoring junction

TNC APC GJC2 FBP2 ITGA2B AQP7P3 GDI2 FOCAD JAK1 FAT2 LRP1 ADAM17 TNS1 CDH6 CNN1 CNN3

9.15e-0497614116GO:0070161
GeneOntologyCellularComponentaxon

EXOC6 FSCN3 SPTA1 APC GRIA3 GJC2 GDI1 CNTN6 KCNA4 CLCN3 PTPRS SLC18A2 LRP1 USH2A DYNC1H1

1.02e-0389114115GO:0030424
GeneOntologyCellularComponentexocytic vesicle membrane

SYN3 APC RAB14 CLCN3 PTPRS SLC18A2

1.37e-031791416GO:0099501
GeneOntologyCellularComponentsynaptic vesicle membrane

SYN3 APC RAB14 CLCN3 PTPRS SLC18A2

1.37e-031791416GO:0030672
GeneOntologyCellularComponentpostsynapse

LHFPL4 SYN3 APC GRIA3 CLSTN2 ADD2 KCNA4 CLCN3 PTPRS SLC18A2 LRP1 FGF7 USP48 KCNT1 CNN3 RPL18A

1.42e-03101814116GO:0098794
GeneOntologyCellularComponentcell body

SLC25A27 DPP6 MYO10 APC GRIA3 GJC2 GDI1 PTPRS SLC18A2 RPTOR LRP1 USH2A DYNC1H1 CNN3 SORL1

1.54e-0392914115GO:0044297
GeneOntologyCellularComponentpostsynaptic membrane

LHFPL4 GRIA3 CLSTN2 KCNA4 CLCN3 PTPRS LRP1 USP48 KCNT1

1.74e-034051419GO:0045211
GeneOntologyCellularComponentsecretory vesicle

MGAM SYN3 APC IDH1 POMT1 ITGA2B HMOX2 ASTL RAB14 GDI2 FRK CLCN3 PTPRS SLC18A2 AGL LRP1 DYNC1H1 IQUB

1.83e-03124614118GO:0099503
DomainFN3

PAPPA2 SDK2 TNC CNTN6 PTPRS USH2A EPHA3 SORL1 EPHA8

1.29e-051851439SM00060
DomainDHC_N1

DNAH10 DNAH8 DYNC1H1

2.39e-0581433PF08385
DomainDynein_heavy_dom-1

DNAH10 DNAH8 DYNC1H1

2.39e-0581433IPR013594
DomainFN3_dom

PAPPA2 SDK2 TNC CNTN6 PTPRS USH2A EPHA3 SORL1 EPHA8

3.38e-052091439IPR003961
Domainfn3

SDK2 TNC CNTN6 PTPRS USH2A EPHA3 SORL1 EPHA8

3.55e-051621438PF00041
DomainFructose_bisphosphatase_AS

FBP2 FBP1

5.82e-0521432IPR020548
DomainRabGDI

GDI1 GDI2

5.82e-0521432IPR000806
DomainFBPtase

FBP2 FBP1

5.82e-0521432IPR028343
DomainFBPase_N

FBP2 FBP1

5.82e-0521432IPR033391
DomainFBPase

FBP2 FBP1

5.82e-0521432PF00316
DomainFBPASE

FBP2 FBP1

5.82e-0521432PS00124
DomainFN3

SDK2 TNC CNTN6 PTPRS USH2A EPHA3 SORL1 EPHA8

1.50e-041991438PS50853
DomainDynein_heavy_chain_D4_dom

DNAH10 DNAH8 DYNC1H1

1.50e-04141433IPR024317
DomainDynein_HC_stalk

DNAH10 DNAH8 DYNC1H1

1.50e-04141433IPR024743
DomainDynein_heavy_dom-2

DNAH10 DNAH8 DYNC1H1

1.50e-04141433IPR013602
DomainDHC_N2

DNAH10 DNAH8 DYNC1H1

1.50e-04141433PF08393
DomainATPase_dyneun-rel_AAA

DNAH10 DNAH8 DYNC1H1

1.50e-04141433IPR011704
DomainMT

DNAH10 DNAH8 DYNC1H1

1.50e-04141433PF12777
DomainAAA_8

DNAH10 DNAH8 DYNC1H1

1.50e-04141433PF12780
DomainAAA_5

DNAH10 DNAH8 DYNC1H1

1.50e-04141433PF07728
DomainUSP_CS

USP18 USP11 USP9Y USP16 USP48

1.51e-04661435IPR018200
DomainFBPase_class-1

FBP2 FBP1

1.74e-0431432IPR000146
DomainK_chnl_volt-dep_ERG

KCNH6 KCNH2

1.74e-0431432IPR003967
DomainEGF-like_CS

TNC HBEGF VWDE FAT2 TENM1 LRP1 ADAM17 SORL1 EPHA8

1.85e-042611439IPR013032
DomainDHC_fam

DNAH10 DNAH8 DYNC1H1

1.87e-04151433IPR026983
DomainDynein_heavy

DNAH10 DNAH8 DYNC1H1

1.87e-04151433PF03028
DomainDynein_heavy_dom

DNAH10 DNAH8 DYNC1H1

1.87e-04151433IPR004273
DomainUSP_1

USP18 USP11 USP9Y USP16 USP48

1.99e-04701435PS00972
DomainEGF_2

TNC HBEGF VWDE FAT2 TENM1 LRP1 EPHA3 SORL1 EPHA8

2.07e-042651439PS01186
DomainUCH

USP18 USP11 USP9Y USP16 USP48

2.13e-04711435PF00443
DomainUSP_2

USP18 USP11 USP9Y USP16 USP48

2.13e-04711435PS00973
DomainUSP_3

USP18 USP11 USP9Y USP16 USP48

2.27e-04721435PS50235
DomainUSP_dom

USP18 USP11 USP9Y USP16 USP48

2.27e-04721435IPR028889
DomainPeptidase_C19_UCH

USP18 USP11 USP9Y USP16 USP48

2.27e-04721435IPR001394
DomainLamGL

PAPPA2 USH2A

3.46e-0441432SM00560
DomainLamG-like

PAPPA2 USH2A

3.46e-0441432IPR006558
DomainGDI

GDI1 GDI2

3.46e-0441432PF00996
DomainCalponin/LIMCH1

CNN1 CNN3

3.46e-0441432IPR001997
DomainGDP_dissociation_inhibitor

GDI1 GDI2

3.46e-0441432IPR018203
Domain-

PAPPA2 ADAMTS5 ASTL ADAM17 MMP19

3.94e-048114353.40.390.10
DomainMetalloPept_cat_dom

PAPPA2 ADAMTS5 ASTL ADAM17 MMP19

3.94e-04811435IPR024079
DomainCalponin_repeat

CNN1 CNN3

8.56e-0461432IPR000557
DomainCalponin

CNN1 CNN3

8.56e-0461432PF00402
DomainCALPONIN_1

CNN1 CNN3

8.56e-0461432PS01052
DomainCALPONIN_2

CNN1 CNN3

8.56e-0461432PS51122
DomainZINC_PROTEASE

PAPPA2 ADAMTS5 ASTL ADAM17 MMP19

9.41e-04981435PS00142
DomainDUSP

USP11 USP48

1.19e-0371432PS51283
Domain-

USP11 USP48

1.19e-03714323.30.2230.10
DomainPept_C19_DUSP

USP11 USP48

1.19e-0371432IPR006615
DomainEGF

TNC HBEGF VWDE FAT2 TENM1 LRP1 SORL1

2.25e-032351437SM00181
DomainEGF_3

TNC HBEGF VWDE FAT2 TENM1 LRP1 SORL1

2.25e-032351437PS50026
DomainPAS_9

KCNH6 KCNH2

2.52e-03101432PF13426
DomainCytokine_IL1-like

ADARB1 FGF3 FGF7

2.61e-03361433IPR008996
DomainSM22_calponin

CNN1 CNN3

3.06e-03111432IPR003096
DomainEGF-like_dom

TNC HBEGF VWDE FAT2 TENM1 LRP1 SORL1

3.10e-032491437IPR000742
DomainPkinase_Tyr

RIPK1 JAK1 FRK EPHA3 EPHA8

3.16e-031291435PF07714
Domain-

TENM1 LRP1 SORL1

3.28e-033914332.120.10.30
DomainEGF_1

TNC HBEGF VWDE FAT2 TENM1 LRP1 USH2A

3.53e-032551437PS00022
DomainProteasome_bsu_CS

PSMA4 PSMB8

3.65e-03121432IPR016050
DomainMit_uncoupling

SLC25A27 UCP2

3.65e-03121432IPR002030
DomainSer-Thr/Tyr_kinase_cat_dom

RIPK1 JAK1 FRK EPHA3 EPHA8

4.21e-031381435IPR001245
Domain6-hairpin_glycosidase-like

LANCL2 AGL

4.30e-03131432IPR008928
DomainTyr_kinase_cat_dom

JAK1 FRK EPHA3 EPHA8

4.67e-03881434IPR020635
DomainTyrKc

JAK1 FRK EPHA3 EPHA8

4.67e-03881434SM00219
DomainRECEPTOR_TYR_KIN_V_2

EPHA3 EPHA8

4.99e-03141432PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHA3 EPHA8

4.99e-03141432PS00790
DomainTyr_kinase_rcpt_V_CS

EPHA3 EPHA8

4.99e-03141432IPR001426
DomainEphA2_TM

EPHA3 EPHA8

4.99e-03141432PF14575
DomainEphrin_rcpt_lig-bd_dom

EPHA3 EPHA8

4.99e-03141432IPR001090
DomainEph_TM

EPHA3 EPHA8

4.99e-03141432IPR027936
DomainK_chnl_volt-dep_EAG/ELK/ERG

KCNH6 KCNH2

4.99e-03141432IPR003938
DomainEPH_lbd

EPHA3 EPHA8

4.99e-03141432SM00615
DomainEphrin_lbd

EPHA3 EPHA8

4.99e-03141432PF01404
DomainLdl_recept_b

LRP1 SORL1

4.99e-03141432PF00058
DomainLDLRB

LRP1 SORL1

4.99e-03141432PS51120
DomainTyr_kinase_ephrin_rcpt

EPHA3 EPHA8

4.99e-03141432IPR016257
DomainEPH_LBD

EPHA3 EPHA8

4.99e-03141432PS51550
Domain-

PAPPA2 SDK2 TNC ICAM3 CNTN6 PTPRS KIR3DL1 KIR3DS1 USH2A EPHA3 SORL1 EPHA8

5.01e-03663143122.60.40.10
Domain6-blade_b-propeller_TolB-like

TENM1 LRP1 SORL1

5.24e-03461433IPR011042
DomainER_TARGET

FKBP10 FKBP9 P3H1

5.57e-03471433PS00014
DomainLY

LRP1 SORL1

5.73e-03151432SM00135
DomainLDLR_classB_rpt

LRP1 SORL1

5.73e-03151432IPR000033
Domain-

PAPPA2 CLSTN2 FAT2 USH2A

6.12e-039514342.60.120.200
DomainFKBP_PPIASE

FKBP10 FKBP9

6.51e-03161432PS50059
DomainFKBP_C

FKBP10 FKBP9

6.51e-03161432PF00254
DomainPROTEIN_KINASE_TYR

JAK1 FRK EPHA3 EPHA8

6.59e-03971434PS00109
DomainTyr_kinase_AS

JAK1 FRK EPHA3 EPHA8

6.59e-03971434IPR008266
DomainPPIase_FKBP

FKBP10 FKBP9

7.34e-03171432IPR023566
Pubmed

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.

SDK2 CLSTN2 CNTN6 TENM1 CDH6 EPHA3 EPHA8

1.20e-0791146728558017
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

FKBP10 TNC NDST2 STT3A P3H1 LRP1 ADAM17 SORL1

5.00e-07164146832409323
Pubmed

Identification of host proteins required for HIV infection through a functional genomic screen.

ZNF536 IDH1 HNRNPF STT3A ZNF512B JAK1 TM9SF2 NUP160 IQUB

2.44e-06272146918187620
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

DPP6 SYN3 TNC SPTA1 FKBP9 APC GJC2 RAB14 GDI1 GDI2 LANCL2 HNRNPF ADD2 GDA PTPRS RPTOR DDX3Y TNS1 DYNC1H1 RPL18A

2.47e-0614311462037142655
Pubmed

Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.

FBP2 IDH1 PGM3 FBP1 AGL GAPDHS

2.79e-0693146627215380
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

GTPBP6 TTC28 USP11 APC ZNF214 HMOX2 USP9Y GDI1 ADARB1 USP16 HNRNPF ZNF512B FOCAD JAK1 HPF1 LRP1 ZNF76 DYNC1H1

7.97e-0612851461835914814
Pubmed

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.

MGAM FBP2 IDH1 ACSS2 FBP1 GAPDHS

9.07e-06114146628245920
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

PSMA4 ITGA2B VWDE HNRNPF HEPH STT3A PTPRS P3H1 LRP1 DDX3Y ADAM17 SORL1

1.17e-056131461222268729
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

FKBP10 GNE USP11 PSMA4 FKBP9 PSMB8 VPS36 IDH1 GDI1 GDI2 HNRNPF GDA P3H1 AGL RIPOR1 USP48 NUP160 DYNC1H1 RPL18A

1.18e-0514551461922863883
Pubmed

Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages.

LRP1 ADAM17

1.75e-052146220610799
Pubmed

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.

ADAMTS5 LRP1

1.75e-052146228306378
Pubmed

No association of KIR3DL1 or KIR3DS1 or their alleles with ankylosing spondylitis.

KIR3DL1 KIR3DS1

1.75e-052146219874556
Pubmed

Evaluation of KIR3DL1/KIR3DS1 polymorphism in Behçet's disease.

KIR3DL1 KIR3DS1

1.75e-052146227708262
Pubmed

Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function.

SLC25A27 UCP2

1.75e-052146224523901
Pubmed

Molecular cloning and gene mapping of human basic and acidic calponins.

CNN1 CNN3

1.75e-05214628526917
Pubmed

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.

ADAMTS5 LRP1

1.75e-052146223064555
Pubmed

Investigation of killer cell immunoglobulin-like receptor gene diversity in KIR3DL1 and KIR3DS1 in a transplant population.

KIR3DL1 KIR3DS1

1.75e-052146218331531
Pubmed

Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations.

KIR3DL1 KIR3DS1

1.75e-052146216805919
Pubmed

Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver.

FBP2 FBP1

1.75e-052146218780768
Pubmed

Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer.

PSMB8 JAK1

1.75e-052146227213585
Pubmed

Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling.

HBEGF ADAM17

1.75e-052146230610007
Pubmed

Role of natural killer cells in a cohort of elite suppressors: low frequency of the protective KIR3DS1 allele and limited inhibition of human immunodeficiency virus type 1 replication in vitro.

KIR3DL1 KIR3DS1

1.75e-052146219211742
Pubmed

Antioncogenic roles of USP9Y and DDX3Y in lung cancer: USP9Y stabilizes DDX3Y by preventing its degradation through deubiquitination.

USP9Y DDX3Y

1.75e-052146238217953
Pubmed

Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1.

KIR3DL1 KIR3DS1

1.75e-052146235192601
Pubmed

Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan children with endemic Burkitt lymphoma.

KIR3DL1 KIR3DS1

1.75e-052146237647275
Pubmed

Association of the KIR3DS1*013 and KIR3DL1*004 alleles with susceptibility to ankylosing spondylitis.

KIR3DL1 KIR3DS1

1.75e-052146220131260
Pubmed

DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia.

USP9Y DDX3Y

1.75e-052146236997603
Pubmed

Protective genotypes in HIV infection reflect superior function of KIR3DS1+ over KIR3DL1+ CD8+ T cells.

KIR3DL1 KIR3DS1

1.75e-052146225112829
Pubmed

Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans.

KIR3DL1 KIR3DS1

1.75e-052146217694054
Pubmed

Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens.

GDI1 GDI2

1.75e-05214627585614
Pubmed

Contribution of functional KIR3DL1 to ankylosing spondylitis.

KIR3DL1 KIR3DS1

1.75e-052146220818412
Pubmed

A method for killer-cell immunoglobulin-like receptor (KIR) 3DL1/3DS1 genotyping using DNA recovered from frozen plasma.

KIR3DL1 KIR3DS1

1.75e-052146223524032
Pubmed

Structure and chromosomal localization of the human and mouse muscle fructose-1,6-bisphosphatase genes.

FBP2 FBP1

1.75e-052146210773464
Pubmed

Various fructose-1,6-bisphosphatase mRNAs in mouse brain, liver, kidney and heart.

FBP2 FBP1

1.75e-05214629106734
Pubmed

Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice.

PSMB8 APC

1.75e-052146228881611
Pubmed

Allele diversity of the killer cell immunoglobulin-like receptors KIR3DL1/S1 and the combination with their HLA ligands in Mexican Mestizos from Mexico City.

KIR3DL1 KIR3DS1

1.75e-052146230365992
Pubmed

Functional polymorphism of the KIR3DL1/S1 receptor on human NK cells.

KIR3DL1 KIR3DS1

1.75e-052146217182560
Pubmed

Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer.

APC EPHA3

1.75e-052146228169277
Pubmed

Genetic control of variegated KIR gene expression: polymorphisms of the bi-directional KIR3DL1 promoter are associated with distinct frequencies of gene expression.

KIR3DL1 KIR3DS1

1.75e-052146219008943
Pubmed

The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity.

FBP2 FBP1

1.75e-052146222517657
Pubmed

Characterization of the mouse liver fructose-1,6-bisphosphatase gene.

FBP2 FBP1

1.75e-052146211250076
Pubmed

UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses.

APC UCP2

1.75e-052146231461648
Pubmed

HLA class I subtype-dependent expansion of KIR3DS1+ and KIR3DL1+ NK cells during acute human immunodeficiency virus type 1 infection.

KIR3DL1 KIR3DS1

1.75e-052146219386717
Pubmed

Putative role of KIR3DL1/3DS1 alleles and HLA-Bw4 ligands with end stage renal disease and long term renal allograft survival.

KIR3DL1 KIR3DS1

1.75e-052146228942035
Pubmed

The profile of KIR3DL1 and KIR3DS1 alleles in an African American population resembles that found in African populations.

KIR3DL1 KIR3DS1

1.75e-052146220230527
Pubmed

Development of a PCR-SSOP approach capable of defining the natural killer cell inhibitory receptor (KIR) gene sequence repertoires.

KIR3DL1 KIR3DS1

1.75e-052146211098931
Pubmed

Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes.

KIR3DL1 KIR3DS1

1.75e-052146219411600
Pubmed

Fructose bisphosphatase isozymes of the mouse. I. Inheritance.

FBP2 FBP1

1.75e-05214622996484
Pubmed

Hepatitis C virus non-structural protein NS3 interacts with LMP7, a component of the immunoproteasome, and affects its proteasome activity.

PSMA4 PSMB8

1.75e-052146215303969
Pubmed

Genetic dissection of the AZF regions of the human Y chromosome: thriller or filler for male (in)fertility?

USP9Y DDX3Y

1.75e-052146220671934
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH10 DNAH8 DYNC1H1

2.55e-051414639373155
Pubmed

DNA sequence and analysis of human chromosome 9.

GNE ECM2 FBP2 RAB14 FBP1 ANKRD19P CARNMT1 KCNT1 MRRF

2.85e-05370146915164053
Pubmed

Deubiquitinating enzymes: a new class of biological regulators.

USP11 USP9Y USP16

3.18e-051514639827704
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

RIPK1 USP11 HMOX2 STT3A FARS2 P3H1 RPTOR LRP1 DDX3Y ILVBL DYNC1H1 EPHA8

3.51e-056861461228380382
Pubmed

A strategy for modulation of enzymes in the ubiquitin system.

USP9Y USP16 USP48

4.72e-0517146323287719
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

RIPK1 TTC28 PSMA4 APC LANCL2 HNRNPF ADD2 STT3A EFR3B DYNC1H1 CNN3 EPHA3

4.75e-057081461239231216
Pubmed

Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia.

SLC25A27 UCP2

5.24e-053146217066476
Pubmed

Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.

ADAMTS5 LRP1

5.24e-053146224474687
Pubmed

A biophysical study on molecular physiology of the uncoupling proteins of the central nervous system.

SLC25A27 UCP2

5.24e-053146226182433
Pubmed

KIR3DS1/L1 and HLA-Bw4-80I are associated with HIV disease progression among HIV typical progressors and long-term nonprogressors.

KIR3DL1 KIR3DS1

5.24e-053146224059286
Pubmed

RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

GDI1 GDI2

5.24e-053146226240314
Pubmed

Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients.

LRP1 TDRD10

5.24e-053146224423473
Pubmed

Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells.

SPTA1 ADD2

5.24e-053146220056793
Pubmed

Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype.

KIR3DL1 KIR3DS1

5.24e-053146211859120
Pubmed

Novel GNE missense variants impair de novo sialylation and cause defective angiogenesis in the developing brain in mice.

GNE ITGA2B

5.24e-053146238237079
Pubmed

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.

LRP1 SORL1

5.24e-053146228799085
Pubmed

Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis.

FGF3 FGF7

5.24e-053146211066089
Pubmed

HERG K(+) currents in human prolactin-secreting adenoma cells.

KCNH6 KCNH2

5.24e-053146212634931
Pubmed

Allelic expression patterns of KIR3DS1 and 3DL1 using the Z27 and DX9 antibodies.

KIR3DL1 KIR3DS1

5.24e-053146217301953
Pubmed

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.

TNC IDH1

5.24e-053146227820599
Pubmed

DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development.

DPP6 MYO10

5.24e-053146223912628
Pubmed

Multiple copies of KIR 3DL/S1 and KIR 2DL4 genes identified in a number of individuals.

KIR3DL1 KIR3DS1

5.24e-053146212826375
Pubmed

Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3.

KCNH6 KCNH2

5.24e-053146214643686
Pubmed

Functional analysis of rat acidic calponin.

CNN1 CNN3

5.24e-053146212033495
Pubmed

The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer.

APC NLK

5.24e-053146228543390
Pubmed

Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport.

GDI1 GDI2

5.24e-05314627543319
Pubmed

Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.

HBEGF ADAM17

5.24e-053146227476853
Pubmed

KIR3DL1/S1 genotypes and KIR2DS4 allelic variants in the AB KIR genotypes are associated with Plasmodium-positive individuals in malaria infection.

KIR3DL1 KIR3DS1

5.24e-053146219859704
Pubmed

Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.

SLC25A27 UCP2

5.24e-053146222524567
Pubmed

Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas.

RASA1 IDH1

5.24e-053146220702649
Pubmed

Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome.

KCNH6 KCNH2

5.24e-053146235818223
Pubmed

The deubiquitinase USP16 functions as an oncogenic factor in K-RAS-driven lung tumorigenesis.

USP16 JAK1

5.24e-053146234294846
Pubmed

Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.

GDI1 GDI2

5.24e-05314627513052
Pubmed

Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis.

KIR3DL1 KIR3DS1

5.24e-053146219019897
Pubmed

Tyrosine phosphorylation of calponins. Inhibition of the interaction with F-actin.

CNN1 CNN3

5.24e-053146215206927
Pubmed

Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.

GDA KCNA4 LRP1

5.65e-0518146319455133
Pubmed

The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.

FKBP10 TTC28 GNE FKBP9 HMGCS1 GDI1 TM9SF2 NUP160

7.36e-05325146836168628
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

USP18 TTC28 MYO10 USP11 PSMA4 APC HMOX2 USP16 LANCL2 FARS2 P3H1 LRP1 USP48 NUP160

9.13e-0510051461419615732
Pubmed

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.

PSMA4 JAK1 RPTOR DYNC1H1

9.24e-0556146427103069
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

GRIA3 GDI1 GDI2 GDA KCNA4 LRP1 DYNC1H1

9.70e-05251146727507650
Pubmed

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer.

APC ADARB1

1.04e-044146229694894
Pubmed

Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling.

HBEGF ADAM17

1.04e-044146212773386
Pubmed

RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?

APC ADAM17

1.04e-044146230022999
Pubmed

Expression profile of KIR3DS1/KIR3DL1 receptors in association with immunological responses in TB, HIV and HIV/TB infected patients.

KIR3DL1 KIR3DS1

1.04e-044146237169313
Pubmed

Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.

KIR3DL1 KIR3DS1

1.04e-044146227455421
Pubmed

The uncoupling proteins.

SLC25A27 UCP2

1.04e-044146211994670
Pubmed

Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM.

SLC25A27 UCP2

1.04e-044146218755175
Pubmed

The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase.

RHOD RASA1

1.04e-044146215187129
Pubmed

PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways.

HBEGF ADAM17

1.04e-044146221386996
Pubmed

ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.

APC ADAM17

1.04e-044146229472497
Cytoband9q22.3

ECM2 FBP2 FBP1

6.79e-061214639q22.3
GeneFamilyFibronectin type III domain containing

SDK2 TNC CNTN6 PTPRS USH2A EPHA3 SORL1 EPHA8

4.25e-061601058555
GeneFamilyUbiquitin specific peptidases

USP18 USP11 USP9Y USP16 USP48

1.81e-05561055366
GeneFamilyFructose-1,6-bisphosphatases

FBP2 FBP1

3.34e-05210521075
GeneFamilyPotassium voltage-gated channels

KCNH6 KCNA4 KCNH2

1.61e-03401053274
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHA3 EPHA8

2.90e-031410521095
GeneFamilyDyneins, axonemal

DNAH10 DNAH8

4.29e-03171052536
GeneFamilyCadherin related

CLSTN2 FAT2

4.29e-0317105224
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR3DL1 KIR3DS1

4.81e-03181052620
GeneFamilyFKBP prolyl isomerases

FKBP10 FKBP9

4.81e-03181052910
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_1000

PAPPA2 TNC MYO10 USP11 FKBP9 GRIA3 ADAMTS5 ANGPTL1 PGM3 CNTN6 FRK PPP3CC P3H1 LRP1 DDX3Y TNS1 EPHA3

1.84e-0576814417gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000

PAPPA2 USP11 FKBP9 GRIA3 HMGCS1 ADAMTS5 IDH1 ANGPTL1 HEPH PGM3 CNTN6 FRK P3H1 LRP1 DDX3Y CNN1 EPHA3

2.00e-0577314417gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlasStromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4

FKBP10 TNC ECM2 FKBP9 ADAMTS5 ANGPTL1 RNASE4 LRP1 FGF7 MMP19 TNS1 EPHA3

4.45e-0543714412GSM777046_500
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000

PAPPA2 TNC USP11 GRIA3 ADAMTS5 CNTN6 FRK LRP1 TNS1 EPHA3

5.21e-0531014410gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k1_1000
CoexpressionAtlasdev gonad_e11.5_F_GonMes_Sma_top-relative-expression-ranked_1000

SDK2 TNC FKBP9 GRIA3 ADAMTS5 PCDH20 CNTN6 PPP3CC PTPRS SLC18A2 KCNH2 P3H1 LRP1 CDH6 KCNT1 CNN1 CNN3

7.35e-0585814417gudmap_dev gonad_e11.5_F_GonMes_Sma_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#3_top-relative-expression-ranked_1000

PAPPA2 USP11 GRIA3 ADAMTS5 HEPH CNTN6 FRK LRP1 CNN1 EPHA3

1.02e-0433614410gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k3_1000
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FKBP10 ZNF536 TNC GRIA3 ADAMTS5 ANGPTL1 PTPRS LRP1 FGF7 CDH6 CNN1 EPHA3

1.47e-121891451245e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FKBP10 ZNF536 TNC ADAMTS5 PTPRS LRP1 FGF7 CDH6 CNN1 EPHA3

7.53e-101911451014057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FKBP10 ZNF536 TNC ADAMTS5 ANGPTL1 PTPRS FGF7 CDH6 CNN1 EPHA3

7.53e-1019114510b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FKBP10 ZNF536 TNC GRIA3 ADAMTS5 PTPRS LRP1 FGF7 EPHA3

9.42e-0918314597eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC25A27 SDK2 TNC MYO10 ADARB1 PTPRS LRP1 FGF7 MMP19

1.25e-0818914592a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA2 FKBP10 ZNF536 TNC ECM2 GRIA3 ANGPTL1 CNN1 CNN3

1.79e-08197145916758f181ef07c60aee63072e1da9572c5c85414
ToppCelldistal-mesenchymal-Fibromyocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PAPPA2 ANKRD35 FKBP10 ZNF536 TNC ECM2 ADAMTS5 ANGPTL1 CNN1

1.87e-0819814599d1d95e7703cfc70a8ad427e400c340dbd205db8
ToppCelldistal-mesenchymal-Fibromyocyte|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PAPPA2 ANKRD35 FKBP10 ZNF536 TNC ECM2 ADAMTS5 ANGPTL1 CNN1

1.87e-081981459fbfac1d10e4224990a094cc84b74bbc206881423
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SLC25A27 FKBP10 SDK2 TNC MYO10 ADARB1 LRP1 FGF7 MMP19

1.95e-081991459a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCelldistal-2-mesenchymal-Myofibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PAPPA2 ANKRD35 FKBP10 ZNF536 TNC ECM2 GRIA3 ANGPTL1 HOGA1

1.95e-081991459b8f3cf5bcfde1066bdb49b14fdc842fe9692a6b7
ToppCellfacs-Trachea-nan-3m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 ECM2 FKBP9 ANGPTL1 STT3A TM9SF2 P3H1 LRP1 CNN3

1.95e-08199145967f78c070c56e44fba36542041bf7fa1c291807c
ToppCellfacs-Trachea-nan-3m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 ECM2 FKBP9 ANGPTL1 STT3A TM9SF2 P3H1 LRP1 CNN3

1.95e-0819914591ae244b563f85c1ee8d22698f478c842a4d9c7f5
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ZNF536 RALYL VWDE KCNA4 ST6GALNAC5 TENM1 GALNTL5 CDH6

1.34e-071791458df6d2cdc4e204ce1a4628dc71dfbc5e6c6309b2a
ToppCellE16.5-samps-Mesenchymal|E16.5-samps / Age Group, Lineage, Cell class and subclass

TNC GRIA3 ADARB1 PTPRS LRP1 FGF7 TNS1 EPHA3

1.96e-0718814583f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 ECM2 FKBP9 ADAMTS5 ANGPTL1 RNASE4 P3H1 LRP1

2.30e-071921458beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 ZNF536 ECM2 GRIA3 ADARB1 ANGPTL1 CNN1 CNN3

2.49e-0719414588fae8061b350336299aa81f378e07deadbd55123
ToppCellControl-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

FKBP10 SYN3 TNC ADARB1 ANGPTL1 ST6GALNAC5 FGF7 CNN3

2.49e-0719414583c2266772c5b56e8e02a461e5193e29588028ee9
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 ZNF536 ECM2 GRIA3 ADARB1 ANGPTL1 CNN1 CNN3

2.49e-0719414584d7d24390fdb379f943ddcc70a63f23955e10163
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

TNC FKBP9 GRIA3 PTPRS LRP1 FGF7 TNS1 EPHA3

2.69e-07196145854f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SLC25A27 SDK2 TNC MYO10 ADARB1 LRP1 FGF7 MMP19

2.79e-071971458fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCelldistal-mesenchymal-Myofibroblast-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PAPPA2 ANKRD35 FKBP10 ZNF536 TNC ECM2 ANGPTL1 HOGA1

2.90e-071981458beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCelldistal-3-mesenchymal-Myofibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PAPPA2 FKBP10 DPP6 TNC ECM2 GRIA3 ANGPTL1 CNN3

3.02e-0719914581f20addc0d138fec02ed6ca4c518169c568de263
ToppCell11.5-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

FKBP10 USP18 ZNF536 ADAMTS5 KCNH2 CDH6 CNN1 CNN3

3.02e-0719914581a8c77d241bd817a195e1532fd25f51358cb1ff1
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

FKBP10 TNC ADAMTS5 ANGPTL1 KCNH2 FGF7 CDH6 CNN1

3.14e-072001458c5e051f1aac8dda376c342a9932785a23450e073
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

FKBP10 TNC ADAMTS5 KCNH2 LRP1 FGF7 CDH6 CNN1

3.14e-0720014589d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

SLC25A27 SDK2 TTC28 TNC MYO10 LRP1 FGF7 MMP19

3.14e-072001458a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

ZNF536 TTC28 TNC ADARB1 TNS1 CDH6 EPHA3

1.56e-06172145736a96714a0eb6ac438648135336c9791881ddadb
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)|Adult / Lineage, Cell type, age group and donor

LHFPL4 RALYL VWDE KCNA4 KCNH2 GAPDHS EPHA3

1.76e-0617514574db1a3c284488b3f6de7568363f176d74e2a4587
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF536 ADAMTS5 GPR149 TENM1 KIR3DL1 CDH6 EPHA8

1.76e-06175145711f49f00e000cbc137e3540a6d6805cde21d96e6
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231|Adult / Lineage, Cell type, age group and donor

LHFPL4 RALYL VWDE KCNA4 KCNH2 GAPDHS EPHA3

1.76e-0617514578d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF536 TNC GRIA3 ADAMTS5 PTPRS LRP1 EPHA3

2.04e-06179145702c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FKBP10 TNC ECM2 ADAMTS5 LRP1 FGF7 MMP19

2.20e-061811457c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FKBP10 TNC ECM2 ADAMTS5 LRP1 FGF7 MMP19

2.20e-061811457c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_PP_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA2 EXOC6 GRIA3 STT3A KCNH6 KCNH2 ST6GALNAC5

2.28e-061821457eb4be1c02b8b033d025e57b8b4cdbfaec4698054
ToppCellMesenchymal_cells-Osteoblasts|Mesenchymal_cells / Lineage and Cell class

FKBP10 PLB1 GNE MYO10 PTPRS KCNH2 P3H1

2.36e-061831457d6b52d52fe9a7a6c798947f05420d79fe12e4662
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF536 TNC GRIA3 ANGPTL1 CDH6 CNN1 EPHA3

2.45e-06184145754e5b63f55b8d6eccad53d389ea9c78f991e1414
ToppCelldroplet-Kidney-nan-21m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD35 GJC2 ADAMTS5 PCDH20 CNTN6 RNASE4 LRP1

2.45e-0618414573bffadb0cb2e0d825bdb6cfc5d23f5436cbc3efd
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF536 TNC GRIA3 ANGPTL1 CDH6 CNN1 EPHA3

2.45e-0618414577b5678718719020b52e7c2a7bd9797987defd7ff
ToppCelldroplet-Kidney-nan-21m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD35 GJC2 ADAMTS5 PCDH20 CNTN6 RNASE4 LRP1

2.54e-06185145733cc0e9d8b54cb7408b51235f2a70e044ebae04d
ToppCelldroplet-Kidney-nan-21m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD35 GJC2 ADAMTS5 PCDH20 CNTN6 RNASE4 LRP1

2.54e-0618514579954fc85b183c1cc45c3c24e3dadc7984ee6f649
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF536 TNC GRIA3 ADAMTS5 KCNH2 LRP1 EPHA3

2.54e-0618514573b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF536 TNC ADAMTS5 FGF7 CDH6 CNN1 EPHA3

2.63e-0618614576add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCellE16.5-samps-Mesenchymal-Myofibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

ZNF536 TNC ADAMTS5 FOCAD FGF7 CNN1 EPHA3

2.63e-061861457e044b3428b7eacfdc72d0f57cdabaa1de04c74cd
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

TTC28 TNC ST6GALNAC5 FGF7 CDH6 CNN1 CNN3

2.73e-061871457464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPP6 MC5R GRIA3 ANGPTL1 PCDH20 CNTN6 LRP1

2.82e-0618814577471c194276161422326647f09022e94f3d1640c
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPP6 MC5R GRIA3 ANGPTL1 PCDH20 CNTN6 LRP1

2.82e-061881457053c251d3ddbeb866f34565aefca4535517b4387
ToppCellfacs-BAT-Fat-18m-Mesenchymal|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 ECM2 ADAMTS5 ANGPTL1 RNASE4 FGF7 MMP19

2.92e-061891457bba28f57a0708515fdd5acd9592dbbe4a4f57116
ToppCellfacs-BAT-Fat-18m-Mesenchymal-mesenchymal_progenitor|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 ECM2 ADAMTS5 ANGPTL1 RNASE4 FGF7 MMP19

2.92e-061891457cf293b23a4c0e8a0c9f09115b1d53d9b11de72e2
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 CLSTN2 ADAMTS5 PTPRS LRP1 FGF7 EPHA3

2.92e-061891457d531399749409d614adca13d181830c6e3287508
ToppCellfacs-Skin-Anagen|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IDH1 GDI2 HNRNPF STT3A TM9SF2 UCP2 DDX3Y

2.92e-061891457adbfc723130079b4caf551f66d2aee86fab1903c
ToppCellfacs-BAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 ECM2 ADAMTS5 ANGPTL1 RNASE4 FGF7 MMP19

2.92e-06189145787323e86a5b5d159920a07e6bd7ef5e3438cd085
ToppCellVE-CD4-CD8_2|VE / Condition, Cell_class and T cell subcluster

SDK2 MYO10 ITGA2B ADD2 ZNF497 IQUB

3.00e-0612214566745035feaf807b6a6b9537ac9d5ee0e000196eb
ToppCellfacs-Skin-Anagen-3m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMGCS1 IDH1 GDI2 HNRNPF STT3A TM9SF2 DDX3Y

3.03e-061901457888ded899f0513d41bf655896d59ae8ef74e0978
ToppCellfacs-Skin-Anagen-3m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMGCS1 IDH1 GDI2 HNRNPF STT3A TM9SF2 DDX3Y

3.03e-0619014573466cebab16964e94da130d0673fa32e7d90b5ed
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANKRD35 ECM2 FKBP9 ADAMTS5 ANGPTL1 LRP1 EPHA3

3.13e-0619114579f478f36a0b895e607e3bb77fa0f9f03cc0f33fc
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNC ADAMTS5 CNTN6 RNASE4 LRP1 FGF7 MMP19

3.24e-06192145784149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 ECM2 CLSTN2 ANGPTL1 LRP1 FGF7 EPHA3

3.24e-061921457c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCelldroplet-Fat-Scat-18m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 FKBP9 ADAMTS5 ITGA2B RNASE4 FGF7 MMP19

3.36e-061931457316ebdf15f75d88c348f909b643fcd315364ca84
ToppCelldroplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 FKBP9 ADAMTS5 ITGA2B RNASE4 FGF7 MMP19

3.36e-0619314571afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYN3 TNC GRIA3 ADARB1 LRP1 FGF7 TNS1

3.36e-0619314574c74a3f69b2cbdf139e7e66b44bd86869ac34dc0
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYN3 TNC GRIA3 ADARB1 LRP1 FGF7 TNS1

3.36e-061931457ff8ceeb3cfd1bef7239df490c19d181091750833
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

SDK2 TTC28 TNC MYO10 ADARB1 PTPRS FGF7

3.36e-061931457acad568621ed677031797b8c2e34dafea798d681
ToppCelldroplet-Fat-Scat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 FKBP9 ADAMTS5 ITGA2B RNASE4 FGF7 MMP19

3.36e-0619314578dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM2 FKBP9 ADAMTS5 ANGPTL1 RNASE4 LRP1 MMP19

3.36e-061931457160691b671710be10220803d788c2c961c236af1
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANKRD35 ECM2 FKBP9 ADAMTS5 ANGPTL1 LRP1 EPHA3

3.36e-061931457051f61156b0e2e95292b2d8377faf3190b50f264
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 ZNF536 ECM2 GRIA3 ANGPTL1 CNN1 CNN3

3.47e-06194145791205b22650e7ecdb72bb59348ce2530b76c532c
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 ZNF536 ECM2 GRIA3 ANGPTL1 CNN1 CNN3

3.47e-0619414576e12a7da35be4c0ecf998ef94b8989b89d74b200
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC25A27 SDK2 TNC ADARB1 PTPRS LRP1 FGF7

3.47e-06194145760622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 ZNF536 ECM2 GRIA3 ANGPTL1 CNN1 CNN3

3.47e-061941457c52f10140c66e8c0566421c3d535d5d92bf595e1
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNC ECM2 FKBP9 ANGPTL1 RNASE4 LRP1 FGF7

3.59e-061951457d2c9c58b46bf96f9a536e177b995e340b55c6750
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

FKBP10 TTC28 CLSTN2 ANGPTL1 PTPRS FGF7 MMP19

3.59e-061951457ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECM2 CLSTN2 ADAMTS5 ANGPTL1 LRP1 FGF7 EPHA3

3.59e-061951457f54bc4454270ff06e85596f98199372b50d0179f
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

DPP6 TTC28 MYO10 ADARB1 PTPRS ST6GALNAC5 FGF7

3.59e-061951457603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell11.5-Distal-Mesenchymal-Airway_Smooth_Muscle|Distal / Age, Tissue, Lineage and Cell class

FKBP10 ZNF536 CLSTN2 ADAMTS5 KCNH2 CDH6 CNN1

3.72e-06196145705530fe7a5681c2f39b95016cd22ef99d6ac0430
ToppCell15-Distal-Mesenchymal-Airway_Smooth_Muscle|Distal / Age, Tissue, Lineage and Cell class

FKBP10 ZNF536 ADAMTS5 CDH6 CNN1 CNN3 RPL18A

3.72e-0619614570e45817625b96d21a8cc4dfbbd465ee6403b6802
ToppCellIPF-Stromal-Myofibroblast|IPF / Disease state, Lineage and Cell class

FKBP10 TNC ECM2 ST6GALNAC5 FGF7 CNN3 EPHA3

3.72e-0619614572d0a48e49b3b37bb66e33e74c52915911e1f8a74
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM2 ADAMTS5 STT3A RNASE4 TM9SF2 LRP1 DDX3Y

3.72e-061961457b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM2 ADAMTS5 STT3A RNASE4 TM9SF2 LRP1 DDX3Y

3.72e-061961457787c6cd92035e0b1108c2c086c42a229016e476b
ToppCellPND01-Mesenchymal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TNC FKBP9 GRIA3 ADARB1 LRP1 FGF7 TNS1

3.84e-061971457292b8cc3dafddf5d323fe4e3d3ea5ac61e6ce027
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FKBP10 ECM2 CLSTN2 ADAMTS5 ANGPTL1 PTPRS FGF7

3.84e-0619714573bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FKBP10 ECM2 CLSTN2 ADAMTS5 ANGPTL1 PTPRS FGF7

3.84e-06197145717344464fdcc5ba0c03959696b97c195f11e644c
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FKBP10 ECM2 CLSTN2 ADAMTS5 ANGPTL1 PTPRS FGF7

3.84e-0619714575b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCelldistal-3-mesenchymal-Fibromyocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PAPPA2 FKBP10 ZNF536 TNC ECM2 ANGPTL1 CNN1

3.97e-061981457dc93886439a378a0c71e99acb8081bfb6b6d467b
ToppCellfacs-Trachea-3m-Mesenchymal|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FKBP10 ECM2 FKBP9 ADAMTS5 RNASE4 LRP1 CNN3

3.97e-061981457e85ae846e293687fd193f4d565525d8d3bd1faea
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 TNC FKBP9 ANGPTL1 PTPRS P3H1 LRP1

3.97e-061981457524305c5d7b1d53e86ec0af775efefa3e0955e47
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 TNC ECM2 FKBP9 ANGPTL1 RNASE4 LRP1

4.11e-061991457edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 ECM2 ADAMTS5 ANGPTL1 RNASE4 FGF7 EPHA3

4.11e-0619914574e128c705ad36fd840582848f278770f356fcc8b
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 ECM2 ADAMTS5 ANGPTL1 RNASE4 FGF7 EPHA3

4.11e-061991457a538da095ba996ee96e263442cf5b6ba9178f3d4
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FKBP10 ECM2 ADAMTS5 ANGPTL1 RNASE4 FGF7 EPHA3

4.11e-0619914574032f03a4165f5f2a90ef1d8315cc743ce9075bb
ToppCellILEUM-inflamed-(8)_Fibroblast|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FKBP10 TNC ANGPTL1 LRP1 FGF7 CNN1 CNN3

4.11e-061991457cb3c04b91c8e8080137823b11c76ca0a2adda52d
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FKBP10 TNC GRIA3 ADAMTS5 KCNH2 LRP1 EPHA3

4.11e-0619914576b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell343B-Fibroblasts-Fibroblast-G|343B / Donor, Lineage, Cell class and subclass (all cells)

DPP6 TNC ANGPTL1 HEPH PTPRS LRP1 FGF7

4.11e-061991457f4b6c095cbe7a38b310adc49be4069e4d56e6a66
ToppCell343B-Fibroblasts-Fibroblast-G-|343B / Donor, Lineage, Cell class and subclass (all cells)

DPP6 TNC ANGPTL1 HEPH PTPRS LRP1 FGF7

4.11e-0619914579c6d1c328bfbb6547f4c7bb2a784576a56bd72af
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FKBP10 ADAMTS5 ANGPTL1 RNASE4 LRP1 FGF7 MMP19

4.25e-062001457933b5b400e48a511ba0a056be1d33d3610b5f10d
ToppCelldistal-mesenchymal-Myofibroblast-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PAPPA2 FKBP10 DPP6 TNC ECM2 GRIA3 ANGPTL1

4.25e-062001457069c8949b33ecfdb6da32992002d4060ff6082bc
ToppCellBiopsy_Control_(H.)-Mesenchymal|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

FKBP10 ECM2 ADAMTS5 ANGPTL1 FGF7 CDH6 CNN1

4.25e-06200145701522ed0b68614b1ebdf190957d44a9d48a6c6e3
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FKBP10 ECM2 ADAMTS5 ANGPTL1 RNASE4 LRP1 FGF7

4.25e-0620014576f7f015b5fa1f52374f2c7d9ba339012395eda5f
ToppCell(6)_Stroma|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

FKBP10 ECM2 ADAMTS5 ANGPTL1 FGF7 CDH6 CNN1

4.25e-062001457f9baef67dde62f1c161a9408a78f635ea70ea9d3
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

FKBP10 TNC GRIA3 ADAMTS5 KCNH2 LRP1 FGF7

4.25e-062001457a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell(6)_Stroma|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

FKBP10 ECM2 ADAMTS5 ANGPTL1 FGF7 CDH6 CNN1

4.25e-062001457f0818821c495022569aef2c1886d9f2446dc027e
DrugVanadates

EXOC6 USP18 MGAM ENPP7 RASA1 TTC28 TNC MYO10 ZNF214 POMT1 HMOX2 USP9Y ADARB1 FBP1 PTPRS UCP2 LRP1 ORAI3 DDX3Y RIPOR1 ADAM17 CPLANE1 CDH6 MRRF

2.78e-06130214624ctd:D014638
Drugmagnesium

MGAM ENPP7 RHOD GTPBP6 RASA1 DNAH10 TNC PSMA4 ICAM3 GRIA3 FBP2 IDH1 ITGA2B FBP1 PPP3CC FARS2 KCNH2 ADAM17 MMP19 DNAH8 MRRF ILVBL DYNC1H1 EPHA3

3.76e-06132514624CID000000888
DrugScoulerine [6451-73-6]; Up 200; 12.2uM; PC3; HT_HG-U133A

MYO10 HBEGF ITGA2B ADARB1 SLC18A2 TENM1 EFR3B CDH6 CNN1

5.06e-0619614695111_UP
DrugEthoxyquin [91-53-2]; Down 200; 18.4uM; PC3; HT_HG-U133A

FKBP10 APC HMGCS1 WDR25 ADARB1 ORAI3 CPLANE1 TNS1 CDH6

5.49e-0619814693764_DN
DrugSA-7

RASA1 HBEGF FGF3 ADAM17 DYNC1H1

7.11e-06421465CID000003300
Drughydroxyl radicals

USP18 MGAM ENPP7 GNE USP11 CLSTN2 FBP2 HMGCS1 IDH1 HMOX2 USP9Y ADARB1 USP16 GDA FBP1 PPP3CC PTPRS SLC18A2 AGL LRP1 CYP4F12 GAPDHS KIR3DL1

1.49e-05134114623CID000000961
Drugcitric acid

MGAM FBP2 IDH1 ITGA2B ACSS2 GDI2 PGM3 RNASE4 FBP1 ADAM17 GAPDHS

2.01e-0535714611CID000000311
Drug6-chloro-6-deoxymannose

FBP2 FBP1 GAPDHS

2.11e-0591463CID000021090
DrugAzacytidine-5 [320-67-2]; Up 200; 16.4uM; MCF7; HT_HG-U133A

HBEGF MC5R CLSTN2 ADAMTS5 ITGA2B ADD2 DDX3Y CNN1

3.58e-0519314683348_UP
DrugNaltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; HL60; HG-U133A

MGAM HMGCS1 HMOX2 RAB14 ADD2 CLCN3 TNS1 DYNC1H1

3.58e-0519314681363_DN
DrugN-(1-(2,3-dimethoxyphenyl)-4-methyl-3-penten-1-yl)-1-(5-bromofurfuryl)-1-piperidyl-4-amine

KCNH6 KCNH2

4.08e-0521462ctd:C531033
Drugimazapic

RPTOR ILVBL

4.08e-0521462CID000091770
DrugMDL-29951

FBP2 FBP1

4.08e-0521462CID005287938
Drugdial-AMP

FBP2 FBP1

4.08e-0521462CID005748329
Drugimidazole pyruvate

FBP2 FBP1

4.08e-0521462CID000000794
Diseaseepilepsy (implicated_via_orthology)

RIPK1 KCNH6 KCNA4 KCNH2 LRP1 KCNT1 DYNC1H1

1.34e-051631407DOID:1826 (implicated_via_orthology)
DiseaseAnimal Mammary Neoplasms

RASA1 PSMA4 APC GDA UCP2 CNN3

6.18e-051421406C0024667
DiseaseMammary Carcinoma, Animal

RASA1 PSMA4 APC GDA UCP2 CNN3

6.18e-051421406C1257925
Diseaseshort QT syndrome (implicated_via_orthology)

KCNH6 KCNH2

6.68e-0531402DOID:0050793 (implicated_via_orthology)
Diseasehereditary spherocytosis type 1 (implicated_via_orthology)

SPTA1 ADD2

1.33e-0441402DOID:0110916 (implicated_via_orthology)
Diseaseblood nickel measurement

FAT2 RPTOR ST6GALNAC5 USH2A TNS1

2.75e-041201405EFO_0007583
DiseaseGlycogen Storage Disease

FBP2 FBP1 AGL

2.81e-04271403C0017919
DiseaseSchizophrenia

SLC25A27 SYN3 MC5R APC GRIA3 ADARB1 KCNH6 FBP1 PPP3CC SLC18A2 KCNH2 UCP2 LRP1

3.08e-0488314013C0036341
Diseasevisceral:subcutaneous adipose tissue ratio

DNAH10 CNTN6 ANKRD19P ADAM17

3.49e-04701404EFO_0004767
Diseasepentachlorophenol measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022071
Diseaseparathion measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022070
Diseasepotassium chromate measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022072
Diseasemercuric chloride measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022068
Diseaseheptachlor epoxide measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022067
Diseasemethoxychlor measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022069
Disease4,6-dinitro-o-cresol measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022053
Disease2,4,5-trichlorophenol measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022052
Diseaseazinphos methyl measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022055
Diseasealdrin measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022054
Diseasedicofol measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022060
Diseasedisulfoton measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022062
Diseasedieldrin measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022061
Diseaseendrin measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022064
Diseaseendosulfan measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022063
Diseaseheptachlor measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022066
Diseaseethion measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022065
Diseasechlorpyrifos measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022057
Diseasecadmium chloride measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022056
Diseasediazinon measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022059
Diseasedibutyl phthalate measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0022058
Diseaseenvironmental exposure measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.10e-04731404EFO_0008360
DiseaseDDT metabolite measurement

RPTOR ST6GALNAC5 USH2A TNS1

4.32e-04741404EFO_0007886
DiseaseAutoinflammatory disorder

USP18 PSMB8 ADAM17

6.12e-04351403C3860213
DiseaseMale sterility due to Y-chromosome deletions

USP9Y DDX3Y

6.14e-0481402C2931163
DiseasePartial chromosome Y deletion

USP9Y DDX3Y

6.14e-0481402C1507149
DiseaseMammary Neoplasms, Experimental

RASA1 PSMA4 GDA UCP2 CNN3

8.84e-041551405C0024668
Diseaselong QT syndrome (implicated_via_orthology)

KCNH6 KCNH2

9.81e-04101402DOID:2843 (implicated_via_orthology)
DiseaseCarcinomatosis

RASA1 PSMA4 GDA UCP2 CNN3

1.11e-031631405C0205699
DiseaseCarcinoma, Spindle-Cell

RASA1 PSMA4 GDA UCP2 CNN3

1.11e-031631405C0205697
DiseaseUndifferentiated carcinoma

RASA1 PSMA4 GDA UCP2 CNN3

1.11e-031631405C0205698
DiseaseAnaplastic carcinoma

RASA1 PSMA4 GDA UCP2 CNN3

1.11e-031631405C0205696
DiseaseCarcinoma

RASA1 PSMA4 GDA UCP2 CNN3

1.14e-031641405C0007097
DiseaseOsteogenesis imperfecta type III (disorder)

FKBP10 P3H1

1.20e-03111402C0268362
Diseaseglycerophosphorylcholine measurement

JAK1 EPHA8

1.20e-03111402EFO_0020018
DiseasePsychotic Disorders

ADARB1 KCNH6 PPP3CC KCNH2

1.39e-031011404C0033975
Diseaseblood cobalt measurement

RPTOR ST6GALNAC5 USH2A TNS1

1.39e-031011404EFO_0007577
Diseasedepressive symptom measurement, stressful life event measurement

RIPK1 RALYL CNTN6

1.74e-03501403EFO_0007006, EFO_0007781
DiseaseColorectal Carcinoma

APC CLSTN2 IDH1 PTPRS TENM1 LRP1 DNAH8 IQUB EPHA3 SORL1

1.96e-0370214010C0009402
DiseaseBipolar Disorder

SYN3 GRIA3 ADARB1 CNTN6 PPP3CC SLC18A2 UCP2 DNAH8

2.05e-034771408C0005586
DiseaseSpermatogenic Failure, Nonobstructive, Y-Linked

USP9Y DDX3Y

2.57e-03161402C1839071
DiseaseSpermatogenic failure, Y-linked, 2

USP9Y DDX3Y

2.57e-03161402cv:C1839071
DiseaseSPERMATOGENIC FAILURE, Y-LINKED, 2

USP9Y DDX3Y

2.57e-03161402415000
Diseasesuccinylcarnitine measurement

ZNF536 SYN3

2.57e-03161402EFO_0020020
Diseaserespiratory symptom change measurement, response to placebo

CNTN6 FARS2

2.90e-03171402EFO_0008344, EFO_0010068
DiseaseTourette syndrome, schizophrenia

ZNF536 DNAH10

3.25e-03181402EFO_0004895, MONDO_0005090
Diseaseunipolar depression, response to bupropion, mood disorder

TNC NLK

3.63e-03191402EFO_0003761, EFO_0004247, EFO_0006326
Diseasesquamous cell carcinoma (is_marker_for)

RIPK1 FGF7

3.63e-03191402DOID:1749 (is_marker_for)
DiseaseAlzheimer's disease (is_implicated_in)

LRP1 ADAM17 GAPDHS SORL1

3.67e-031321404DOID:10652 (is_implicated_in)
Diseaseserum homoarginine measurement

WDR25 TNS1

4.02e-03201402EFO_0005421
DiseaseNonorganic psychosis

KCNH6 PPP3CC KCNH2

4.36e-03691403C0349204
DiseaseOsteogenesis imperfecta

FKBP10 P3H1

4.42e-03211402cv:C0029434
DiseaseLung Injury

TNC FGF7

4.42e-03211402C0273115
DiseaseChronic Lung Injury

TNC FGF7

4.42e-03211402C2350344
Diseasecardiomyopathy (implicated_via_orthology)

PPP3CC LRP1 QRSL1

4.72e-03711403DOID:0050700 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
MESLRGYTHSDIGYR

ESX1

1

Q8N693
QLHYMVYCRNTGGRY

PGM3

161

O95394
NAFRYYGTSMHERVN

CARNMT1

71

Q8N4J0
DASMARLYGRGLQHY

ADAMTS5

276

Q9UNA0
LSSMDQEYAGRGYHI

ANKRD18B

16

A2A2Z9
AEYRGGSYSLRAVQM

ANGPTL1

471

O95841
TYRNHLLNAARGYME

ANKRD35

971

Q8N283
MRTVYGNHERFETTY

ACSS2

526

Q9NR19
IYGVGSMSRYEQVLH

CLSTN2

736

Q9H4D0
DYSSVMHYGRLAFSR

ASTL

231

Q6HA08
LDSMDQEYAGRGYHI

ANKRD19P

16

Q9H560
RGLRGTHMQHAYDFY

HMGCS1

191

Q01581
SYGRVLLAVYRMHSA

OR2L2

216

Q8NH16
VTRSYYRGAAGALMV

RAB14

76

P61106
YRGAAGALMVYDITR

RAB14

81

P61106
GYAFVQYMSERHARA

RALYL

56

Q86SE5
MGGRYYNSIGDIIDH

RASA1

411

P20936
RGTRTHIYSGTLMDY

JAK1

591

P23458
MDYLGSRQYVHRDLA

JAK1

991

P23458
LAYYAAMLGEEHTRS

P3H1

341

Q32P28
GDNKTQYHMGYFRDS

HPF1

121

Q9NWY4
THRDSYSGGVVNMYH

PSMB8

236

P28062
TYREFVHRGYLDLMG

ORAI3

26

Q9BRQ5
INGVQTYRLLDYHGM

PCDH20

241

Q8N6Y1
LHMDRNPYYGGESAS

GDI2

31

P50395
YRGRMSSAALIHHYT

HOGA1

141

Q86XE5
LEAERMTHGYYLASR

MCMDC2

556

Q4G0Z9
MTHGYYLASRRIRTG

MCMDC2

561

Q4G0Z9
DVAHLYRGVGSRYIM

GTPBP6

236

O43824
SVMYLGYAVHRLARA

GJC2

91

Q5T442
DAIYSARYDGSGHME

LRP1

1456

Q07954
YHGMNTGYAINPSRD

AQP7P3

216

A6NL99
HLSRYEYGTLDNMRE

MGAM

381

O43451
YLAMNKRGRLYASEH

FGF3

96

P11487
GNSALRRVMEETYYH

FICD

211

Q9BVA6
QRMYGRCSGNEVYHI

KCNT1

531

Q5JUK3
LYSGTARYHTQMLRV

KCNH2

666

Q12809
QRLYSGTARYHTQML

KCNH6

516

Q9H252
RKQYVGAAHGMAGIY

LANCL2

256

Q9NS86
YGARYVGSMVADVHR

FBP2

241

O00757
RYHANSMGQRSYSFE

HMBOX1

136

Q6NT76
SRSSYDMYHLSREGG

KIR3DL1

246

P43629
RGYHYMLANLGFTDI

GRIA3

241

P42263
RYVLMDGAHGTFRVD

FAT2

961

Q9NYQ8
GHSRYSQALMAPVYE

MMP19

221

Q99542
GRHRYGYVCIAMEAL

EFR3B

66

Q9Y2G0
IRMIHGVSRYYNTSE

DNAH8

266

Q96JB1
GGRYDVHLGERMRYA

DDHD2

86

O94830
GLYEPATMEQYSRRH

MYO10

111

Q9HD67
AHAYTRYMGDLSGGQ

HMOX2

151

P30519
YRAPEILMGSRHYSN

NLK

306

Q9UBE8
YHGDHLSRAMYQRIS

ADARB1

591

P78563
YHEHYMRNSRAIGVL

LHFPL4

11

Q7Z7J7
QSNMHETVDGYRRYF

EXOC6

321

Q8TAG9
LMYVFREHQRSGSYH

ICAM3

506

P32942
YQVHYVRMEGAEARG

PTPRS

756

Q13332
DVYGHVTLMRSQRNY

PTPRS

1616

Q13332
LVSYNFYTMHRGVGS

GPR149

126

Q86SP6
DTYPMIYENGRGSSH

POMT1

346

Q9Y6A1
YGARYVGSMVADVHR

FBP1

241

P09467
SHNRMKTYDTYVGIG

FKBP9

186

O95302
YDGRHMALYVDGTQV

PAPPA2

371

Q9BXP8
VTYHRGQEMARSVGA

RHOD

151

O00212
GMAYLESRNYIHRDL

FRK

341

P42685
RRAGAGDFMRYHYNG

FKBP10

281

Q96AY3
EAAHGTVTRHYRMYQ

IDH1

306

O75874
AYTDYHKAAMGLGAR

ILVBL

571

A1L0T0
LGSHLIDDYGNTYRM

GNE

46

Q9Y223
SEHYSRRISQAYGLM

CPLANE1

2956

Q9H799
ASNMARFDGLQYGHR

QRSL1

336

Q9H0R6
TGHDMTRQVSSYYGG

FNIP1

951

Q8TF40
AGMRYLSDLGYVHRD

EPHA8

746

P29322
QHMDFLYYLSHDGRR

CYP4F12

241

Q9HCS2
YYLSQRRHRAVMADG

FSCN3

316

Q9NQT6
AMSGGIFAIRRHYFN

GALNTL5

306

Q7Z4T8
FTMSYHYRLDGGSLA

CNTN6

71

Q9UQ52
YLSDMGYVHRDLAAR

EPHA3

736

P29320
DGMDRVSFYGAYHSL

ECM2

596

O94769
YALRYHHIMTARRSG

MC5R

146

P33032
ASIGRHRYIAYMANQ

IQUB

446

Q8NA54
SFIRQMVEHGGFYRT

DYNC1H1

2681

Q14204
VAGGYSYSMLDAIRR

GDA

331

Q9Y2T3
TRKNGYNRHEMSTYL

CDH6

551

P55285
LHMDRNPYYGGESSS

GDI1

31

P31150
LLMFRYHRRGGYDVE

HBEGF

181

Q99075
NMAYEHHYKGGSRGR

DDX3Y

571

O15523
YLGLHGLDNRAYEMT

DPP6

756

P42658
LMYSDLGYVIHGRIN

ENPP7

331

Q6UWV6
RHTRSYDYMEGGDIR

FGF7

51

P21781
GYSHRVVDLLRYMFS

GAPDHS

391

O14556
FLRYTAGIQRMLDHY

DNAH10

701

Q8IVF4
YMITSLDRTHAGFYR

SDK2

76

Q58EX2
GRLYQVEYAMEAIGH

PSMA4

16

P25789
YMNRAYHAILQGRLG

FOCAD

896

Q5VW36
GRDLSYCLSGMYDHR

HNRNPF

261

P52597
QHAYSMALGEDYRSL

SYN3

166

O14994
YEYRVLMSTLHGGTN

USH2A

2696

O75445
GIYRSNMDGSAAYHL

SORL1

901

Q92673
HRKQYGGDFLRARMY

NXPE2

141

Q96DL1
MRGTRCLAEYHLGDY

TDRD10

246

Q5VZ19
AGSHREAGMRAIYNV

HEPH

701

Q9BQS7
MRALAGTYRCYGSVT

KIR3DS1

186

Q14943
SRSSYDMYHLSREGG

KIR3DS1

246

Q14943
LMLTGRFSHRIYVAY

STT3A

226

P46977
ERQHGHRQYMAYSAV

MRRF

36

Q96E11
GYQTDMHSVSRHGYQ

TENM1

86

Q9UKZ4
RHSLQTMLSVGYYRN

TENM1

1921

Q9UKZ4
YMRRDGKGQVYNNLH

ST6GALNAC5

176

Q9BVH7
LRGEQMASYFGHSVA

ITGA2B

311

P08514
YRSSMRELVGSGRYD

PLB1

951

Q6P1J6
EANYHLYGSRMDRQT

RIPK1

381

Q13546
SRSGTHNMYREYRDL

RPL18A

86

Q02543
HNMYREYRDLTTAGA

RPL18A

91

Q02543
RHNYRKAGTVMFEYG

NUP160

1091

Q12769
HNGNPRYTRVTAMEY

RPTOR

1061

Q8N122
MLDNLGYRTGYTYRH

ADD2

371

P35612
ADHRFYRYMGRGEES

ADAM17

231

P78536
DHYSITLRRYAGMAL

APC

491

P25054
SRSHGTDLYRGEKMY

CIR1

421

Q86X95
MESEQLFHRGYYRNS

CLCN3

1

P51790
QQGMTAYGTRRHLYD

CNN1

176

P51911
QAGMTAYGTRRHLYD

CNN3

176

Q15417
AHEAQDAGYRMYRKS

PPP3CC

276

P48454
SYGQDGMYQRFLRQH

RNASE4

26

P34096
YTQGRGSHSQEMRYN

VWDE

731

Q8N2E2
RYMNSALGQYSSAGH

UCP2

241

P55851
GQAFVMGSYLAEHRR

ZNF497

336

Q6ZNH5
TRETYGSGTQYHMQL

VPS36

231

Q86VN1
LYSLYGVVEHSGTMR

USP16

741

Q9Y5T5
LYRDVMRETYGHLGA

ZNF747

61

Q9BV97
NRGRIGVVIAAYMHY

TNS1

116

Q9HBL0
YRNCHRVNLMGRYGD

TNC

2146

P24821
YRHVVYSGGRMVTYE

SLC25A27

96

O95847
YSGGRMVTYEHLREV

SLC25A27

101

O95847
MTHLSNYGNDRLGLY

NDST2

526

P52849
MDPRGRSHLSGYDYV

SPTA1

2396

P02549
LATYMNSIRLYAGDH

USP9Y

621

O00507
YRDVMQETYGHLGAL

ZNF688

51

P0C7X2
GGMSQEAHANLYSRY

ZNF536

416

O15090
SSLMGYQYHQRRCGK

ZNF512B

606

Q96KM6
GSAYHYRRNFDKAMS

TTC28

401

Q96AY4
IYYHVVETGSMGARL

TM9SF2

216

Q99805
VGMADSGHYCVYIRN

USP41

311

Q3LFD5
VGMADSGHYCVYIRN

USP18

311

Q9UMW8
MSRRRRYEGHKVEGY

WDR25

461

Q64LD2
MVGSALRRGAHAYVY

FARS2

1

O95363
GDNYYLNRTHMLRAH

FARS2

141

O95363
MGYLVDLRHVSVYGS

SLC18A2

406

Q05940
LRDGAYNMVRAYTTG

RIPOR1

156

Q6ZS17
GTHCSRNAYMLVYRL

USP48

406

Q86UV5
KYDLIAVSNHYGGMR

USP11

871

P51784
TTQDYGREIYMSGSH

ZNF214

146

Q9UL59
DGSMAYIHRTPREGY

ZNF76

66

P36508
YRDVMRETYGHLSAL

ZNF764

51

Q96H86
MSAYNSHEEGRLVYR

AGL

581

P35573
HMPYGYAAQARARER

KCNA4

16

P22459