Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribosome binding	PTTG3P PTTG1 ABCF1	3.00e-04	120	22	3	GO:0043022
GeneOntologyMolecularFunction	gap junction channel activity	GJA10 PANX2	3.42e-04	25	22	2	GO:0005243
GeneOntologyMolecularFunction	wide pore channel activity	GJA10 PANX2	7.54e-04	37	22	2	GO:0022829
GeneOntologyMolecularFunction	cysteine-type endopeptidase inhibitor activity	PTTG3P PTTG1	1.02e-03	43	22	2	GO:0004869
GeneOntologyMolecularFunction	ribonucleoprotein complex binding	PTTG3P PTTG1 ABCF1	1.44e-03	206	22	3	GO:0043021
GeneOntologyMolecularFunction	translation factor activity, RNA binding	ABCF1 EIF4B	3.91e-03	85	22	2	GO:0008135
GeneOntologyMolecularFunction	translation regulator activity, nucleic acid binding	ABCF1 EIF4B	6.69e-03	112	22	2	GO:0090079
Pathway	REACTOME_ELECTRIC_TRANSMISSION_ACROSS_GAP_JUNCTIONS	GJA10 PANX2	7.84e-06	5	13	2	MM14497
Pathway	REACTOME_ELECTRIC_TRANSMISSION_ACROSS_GAP_JUNCTIONS	GJA10 PANX2	7.84e-06	5	13	2	M29532
Pubmed	Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients.	PTTG3P PTTG1	3.82e-07	2	22	2	33173433
Pubmed	The lncRNA PTTG3P promotes the progression of CRPC via upregulating PTTG1.	PTTG3P PTTG1	3.82e-07	2	22	2	33743960
Pubmed	The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma.	PTTG3P PTTG1	3.82e-07	2	22	2	29803224
Pubmed	Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.	PTTG3P PTTG1	1.15e-06	3	22	2	24395789
Pubmed	Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division.	PTTG3P PTTG1	1.15e-06	3	22	2	11682618
Pubmed	PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines.	PTTG3P PTTG1	1.15e-06	3	22	2	17652795
Pubmed	Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging.	PTTG3P PTTG1	1.15e-06	3	22	2	33173537
Pubmed	Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells.	PTTG3P PTTG1	1.15e-06	3	22	2	16959877
Pubmed	Characterization of the murine pituitary tumor transforming gene (PTTG) and its promoter.	PTTG3P PTTG1	1.15e-06	3	22	2	10650958
Pubmed	Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells.	PTTG3P PTTG1	1.15e-06	3	22	2	23867215
Pubmed	The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.	PTTG3P PTTG1	1.15e-06	3	22	2	31073078
Pubmed	A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.	PTTG3P PTTG1	1.15e-06	3	22	2	34262048
Pubmed	Characterization of the pituitary tumor transforming gene 1 knockout mouse retina.	PTTG3P PTTG1	1.15e-06	3	22	2	21203837
Pubmed	Pituitary tumor transforming gene (PTTG) transforming and transactivation activity.	PTTG3P PTTG1	1.15e-06	3	22	2	10713046
Pubmed	Pituitary tumor transforming gene as a novel regulatory factor of liver fibrosis.	PTTG3P PTTG1	1.15e-06	3	22	2	25936962
Pubmed	Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes.	PTTG3P PTTG1	1.15e-06	3	22	2	16322543
Pubmed	PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis.	PTTG3P PTTG1	1.15e-06	3	22	2	36737842
Pubmed	Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells.	PTTG3P PTTG1	1.15e-06	3	22	2	17065388
Pubmed	Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells.	PTTG3P PTTG1	1.15e-06	3	22	2	17626243
Pubmed	Pituitary tumor transforming gene: an update.	PTTG3P PTTG1	1.15e-06	3	22	2	15281346
Pubmed	Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes.	PTTG3P PTTG1	1.15e-06	3	22	2	12626748
Pubmed	Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II.	PTTG3P PTTG1	1.15e-06	3	22	2	28516917
Pubmed	PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression.	PTTG3P PTTG1	1.15e-06	3	22	2	37159932
Pubmed	Pituitary senescence: the evolving role of Pttg.	PTTG3P PTTG1	1.15e-06	3	22	2	20153804
Pubmed	Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs.	PTTG3P PTTG1	1.15e-06	3	22	2	18639540
Pubmed	Sex-steroid milieu determines diabetes rescue in pttg-null mice.	PTTG3P PTTG1	1.15e-06	3	22	2	16731783
Pubmed	Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis.	PTTG3P PTTG1	2.29e-06	4	22	2	15919720
Pubmed	Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.	PTTG3P PTTG1	2.29e-06	4	22	2	17039256
Pubmed	Pituitary tumor transforming gene 1 induces tumor necrosis factor-α production from keratinocytes: implication for involvement in the pathophysiology of psoriasis.	PTTG3P PTTG1	2.29e-06	4	22	2	23677169
Pubmed	Anaphase B precedes anaphase A in the mouse egg.	PTTG3P PTTG1	2.29e-06	4	22	2	22342753
Pubmed	Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells.	PTTG3P PTTG1	2.29e-06	4	22	2	25421944
Pubmed	Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells.	PTTG3P PTTG1	2.29e-06	4	22	2	16030258
Pubmed	Tumorigenic potential of pituitary tumor transforming gene (PTTG) in vivo investigated using a transgenic mouse model, and effects of cross breeding with p53 (+/-) transgenic mice.	PTTG3P PTTG1	2.29e-06	4	22	2	23164239
Pubmed	Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation.	PTTG3P PTTG1	2.29e-06	4	22	2	19124608
Pubmed	Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice.	PTTG3P PTTG1	2.29e-06	4	22	2	23861251
Pubmed	A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1.	PTTG3P PTTG1	2.29e-06	4	22	2	17234588
Pubmed	Induction of Dlk1 by PTTG1 inhibits adipocyte differentiation and correlates with malignant transformation.	PTTG3P PTTG1	2.29e-06	4	22	2	19477929
Pubmed	Degradation of securin in mouse and pig oocytes is dependent on ubiquitin-proteasome pathway and is required for proteolysis of the cohesion subunit, Rec8, at the metaphase-to-anaphase transition.	PTTG3P PTTG1	2.29e-06	4	22	2	16720305
Pubmed	The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.	PTTG3P PTTG1	2.29e-06	4	22	2	35050550
Pubmed	Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1.	PTTG3P PTTG1	2.29e-06	4	22	2	14593421
Pubmed	The pituitary tumor-transforming gene promotes angiogenesis in a mouse model of follicular thyroid cancer.	PTTG3P PTTG1	2.29e-06	4	22	2	17127711
Pubmed	Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice.	PTTG3P PTTG1	2.29e-06	4	22	2	30259712
Pubmed	Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.	PTTG3P PTTG1	2.29e-06	4	22	2	20116377
Pubmed	Securin regulates entry into M-phase by modulating the stability of cyclin B.	PTTG3P PTTG1	2.29e-06	4	22	2	18364698
Pubmed	Expression of PTTG and prc1 genes during telencephalic neurogenesis.	PTTG3P PTTG1	2.29e-06	4	22	2	10727870
Pubmed	Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics.	PTTG3P PTTG1	2.29e-06	4	22	2	24927528
Pubmed	Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts.	PTTG3P PTTG1	2.29e-06	4	22	2	11516952
Pubmed	Glypican-1 regulates anaphase promoting complex/cyclosome substrates and cell cycle progression in endothelial cells.	PTTG3P PTTG1	2.29e-06	4	22	2	18417614
Pubmed	The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase.	PTTG3P PTTG1	2.29e-06	4	22	2	16533944
Pubmed	Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.	PTTG3P PTTG1	2.29e-06	4	22	2	16533945
Pubmed	MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte.	PTTG3P PTTG1	3.82e-06	5	22	2	39093409
Pubmed	Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.	PTTG3P PTTG1	3.82e-06	5	22	2	21156286
Pubmed	Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth.	PTTG3P PTTG1	3.82e-06	5	22	2	17975001
Pubmed	PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.	PTTG3P PTTG1	3.82e-06	5	22	2	22535767
Pubmed	p21(Cip1) restrains pituitary tumor growth.	PTTG3P PTTG1	3.82e-06	5	22	2	18981426
Pubmed	Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition.	PTTG3P PTTG1	3.82e-06	5	22	2	28658604
Pubmed	The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity.	PTTG3P PTTG1	3.82e-06	5	22	2	14561405
Pubmed	The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.	PTTG3P PTTG1	3.82e-06	5	22	2	16355229
Pubmed	Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice.	PTTG3P PTTG1	3.82e-06	5	22	2	21076990
Pubmed	mTOR promotes pituitary tumor development through activation of PTTG1.	PTTG3P PTTG1	5.72e-06	6	22	2	27524416
Pubmed	Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells.	PTTG3P PTTG1	5.72e-06	6	22	2	33181265
Pubmed	Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation.	PTTG3P PTTG1	5.72e-06	6	22	2	21991377
Pubmed	Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos.	PTTG3P PTTG1	8.01e-06	7	22	2	17325031
Pubmed	Identification of disease-relevant modulators of the SHH pathway in the developing brain.	PTTG3P PTTG1	1.37e-05	9	22	2	34463328
Pubmed	Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.	PTTG3P PTTG1	1.71e-05	10	22	2	26731471
Pubmed	Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis.	PTTG3P PTTG1	2.09e-05	11	22	2	21494564
Pubmed	Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence.	PTTG3P PTTG1	2.97e-05	13	22	2	19213844
Pubmed	Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure.	PTTG3P PTTG1	2.97e-05	13	22	2	34571959
Pubmed	TIF1β association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis.	PTTG3P PTTG1	3.99e-05	15	22	2	21163256
Pubmed	Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells.	PTTG3P PTTG1	4.56e-05	16	22	2	18232736
Pubmed	Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions.	PTTG3P PTTG1	7.96e-05	21	22	2	15937080
Pubmed	Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney development.	PTTG3P PTTG1	1.23e-04	26	22	2	37727504
Pubmed	Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye.	PTTG3P PTTG1	1.33e-04	27	22	2	23676271
Pubmed	Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development.	PTTG3P PTTG1	1.64e-04	30	22	2	16420439
Pubmed	Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma.	PTTG3P PTTG1	2.12e-04	34	22	2	34050187
Pubmed	Individual retinal progenitor cells display extensive heterogeneity of gene expression.	PTTG3P PTTG1	3.09e-04	41	22	2	18270576
Pubmed	TRIM6 promotes colorectal cancer cells proliferation and response to thiostrepton by TIS21/FoxM1.	ABCF1 EIF4B	3.40e-04	43	22	2	31992359
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	RAPH1 ABCF1 EIF4B	5.47e-04	256	22	3	33397691
Pubmed	Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior.	PTTG3P PTTG1	5.76e-04	56	22	2	29184203
Pubmed	Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure.	PTTG3P PTTG1	6.18e-04	58	22	2	37973188
Coexpression	MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN	GCLC PTTG3P PTTG1	2.71e-05	70	22	3	MM994
Disease	fasting blood insulin measurement	PTTG1 MAP3K19	8.98e-04	69	19	2	EFO_0004466
Disease	Contact hypersensitivity	GLB1 GCLC	9.51e-04	71	19	2	C0162351
Disease	Contact Dermatitis	GLB1 GCLC	9.51e-04	71	19	2	C0011616
Disease	multiple sclerosis	GLB1 POU2AF1 HOXA1	6.19e-03	594	19	3	MONDO_0005301

Protein segments in the cluster

Peptide	Gene	Start	Entry
MPKAPKQQPPEPEWI	ABCF1	1	Q8NE71
KWPPGHPVKNLPQMR	B4GALNT3	531	Q6L9W6
VPKSKTMWQIPQPRQ	GJA10	296	Q969M2
PLRGWPQPKMKSSRQ	HSD11B1L	261	Q7Z5J1
NLTPKPNRMPPWKRK	C6orf201	51	Q7Z4U5
PNRMPPWKRKIINNV	C6orf201	56	Q7Z4U5
PRKPSVPWQRQMDQP	RASAL3	861	Q86YV0
PQPQQWSKMSVKKAP	RAPH1	1106	Q70E73
NGWKNPKPPTAPRMD	KAT2A	121	Q92830
LMPPPPQKNKDSWLD	GLB1	661	P16278
WQTMRFKPPPPNSDI	GCLC	406	P48506
MEPSSKQKQPRPWPQ	LMNTD2	231	Q8IXW0
PAQTFDWMKVKRNPP	HOXA1	201	P49639
VKPPDWPNPMNATSQ	POGK	126	Q9P215
MLWQKPTAPEQAPAP	POU2AF1	1	Q16633
DPRPWQLPRFQKKMP	MAP3K19	581	Q56UN5
PVKMPSPPWESNLLQ	PTTG1	166	O95997
PRKKMKWIPTSNPLP	PANX2	426	Q96RD6
LKVMPAPPPKENAWV	EIF4B	471	P23588
KSQWMKGPQCLPPPA	NUTM2D	346	Q5VT03
PLKMPSPPWKSNLLQ	PTTG3P	166	Q9NZH4
QKPQPPRGQPKMDWK	TCTN3	551	Q6NUS6
PWNRKRQEMVAKPPV	ZNF680	71	Q8NEM1
PPPKLFWKRNNEMVQ	MYOT	376	Q9UBF9