Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	BCKDHA BCKDHB	2.84e-05	2	107	2	GO:0003863
GeneOntologyMolecularFunction	branched-chain alpha-keto acid dehydrogenase activity	BCKDHA BCKDHB	1.69e-04	4	107	2	GO:0047101
GeneOntologyBiologicalProcess	siRNA-mediated post-transcriptional gene silencing	AGO2 AGO1 AGO4	5.41e-07	4	107	3	GO:0140766
GeneOntologyBiologicalProcess	siRNA-mediated gene silencing by mRNA destabilization	AGO2 AGO1 AGO4	5.41e-07	4	107	3	GO:0090625
GeneOntologyBiologicalProcess	RNA secondary structure unwinding	AGO2 AGO1 AGO4	1.11e-05	9	107	3	GO:0010501
GeneOntologyBiologicalProcess	RISC complex assembly	AGO2 AGO1 AGO4	1.59e-05	10	107	3	GO:0070922
GeneOntologyBiologicalProcess	pre-miRNA processing	AGO2 AGO1 AGO4	8.75e-05	17	107	3	GO:0031054
GeneOntologyCellularComponent	RISC-loading complex	AGO2 AGO1 AGO4	1.52e-05	10	107	3	GO:0070578
GeneOntologyCellularComponent	branched-chain alpha-ketoacid dehydrogenase complex	BCKDHA BCKDHB	2.60e-05	2	107	2	GO:0160157
Domain	Argonaute_N	AGO2 AGO1 AGO4	6.12e-07	4	101	3	IPR032474
Domain	Argonaute_Mid_dom	AGO2 AGO1 AGO4	6.12e-07	4	101	3	IPR032473
Domain	ArgoL2	AGO2 AGO1 AGO4	6.12e-07	4	101	3	IPR032472
Domain	ArgoN	AGO2 AGO1 AGO4	6.12e-07	4	101	3	PF16486
Domain	ArgoMid	AGO2 AGO1 AGO4	6.12e-07	4	101	3	PF16487
Domain	ArgoL2	AGO2 AGO1 AGO4	6.12e-07	4	101	3	PF16488
Domain	DUF1785	AGO2 AGO1 AGO4	1.52e-06	5	101	3	SM01163
Domain	ArgoL1	AGO2 AGO1 AGO4	3.03e-06	6	101	3	PF08699
Domain	ArgoL1	AGO2 AGO1 AGO4	3.03e-06	6	101	3	IPR014811
Domain	PIWI	AGO2 AGO1 AGO4	8.43e-06	8	101	3	PS50822
Domain	Piwi	AGO2 AGO1 AGO4	8.43e-06	8	101	3	SM00950
Domain	Piwi	AGO2 AGO1 AGO4	8.43e-06	8	101	3	PF02171
Domain	Piwi	AGO2 AGO1 AGO4	8.43e-06	8	101	3	IPR003165
Domain	PAZ	AGO2 AGO1 AGO4	1.26e-05	9	101	3	PS50821
Domain	PAZ	AGO2 AGO1 AGO4	1.26e-05	9	101	3	SM00949
Domain	PAZ	AGO2 AGO1 AGO4	1.26e-05	9	101	3	PF02170
Domain	PAZ_dom	AGO2 AGO1 AGO4	1.26e-05	9	101	3	IPR003100
Domain	EGF_CA	FAT4 EGF LRP2 C1S	1.22e-03	86	101	4	PF07645
Domain	EGF_Ca-bd_CS	FAT4 EGF LRP2 C1S	1.90e-03	97	101	4	IPR018097
Domain	EGF_CA	FAT4 EGF LRP2 C1S	2.05e-03	99	101	4	PS01187
Domain	-	AGO2 AGO1 AGO4	2.09e-03	47	101	3	3.30.420.10
Domain	ASX_HYDROXYL	FAT4 EGF LRP2 C1S	2.12e-03	100	101	4	PS00010
Domain	THDP-binding	BCKDHA BCKDHB	2.17e-03	13	101	2	IPR029061
Domain	-	BCKDHA BCKDHB	2.17e-03	13	101	2	3.40.50.970
Domain	Ig_E-set	NXPE1 PKHD1L1 EBF2 SUOX	2.45e-03	104	101	4	IPR014756
Domain	Ldl_recept_b	EGF LRP2	2.53e-03	14	101	2	PF00058
Domain	LDLRB	EGF LRP2	2.53e-03	14	101	2	PS51120
Domain	EGF-type_Asp/Asn_hydroxyl_site	FAT4 EGF LRP2 C1S	2.62e-03	106	101	4	IPR000152
Domain	PI3/4_kinase_CS	MTOR PIK3CG	2.90e-03	15	101	2	IPR018936
Domain	LY	EGF LRP2	2.90e-03	15	101	2	SM00135
Domain	LDLR_classB_rpt	EGF LRP2	2.90e-03	15	101	2	IPR000033
Domain	-	MTOR PIK3CG	3.31e-03	16	101	2	1.10.1070.11
Domain	PI3Kc	MTOR PIK3CG	3.31e-03	16	101	2	SM00146
Domain	ZF_C3H1	ZFC3H1 HELZ CNOT4	3.82e-03	58	101	3	PS50103
Domain	PI3_PI4_kinase	MTOR PIK3CG	4.19e-03	18	101	2	PF00454
Domain	PI3_4_KINASE_1	MTOR PIK3CG	4.19e-03	18	101	2	PS00915
Domain	PI3_4_KINASE_2	MTOR PIK3CG	4.19e-03	18	101	2	PS00916
Domain	PI3/4_kinase_cat_dom	MTOR PIK3CG	4.19e-03	18	101	2	IPR000403
Domain	PI3_4_KINASE_3	MTOR PIK3CG	4.19e-03	18	101	2	PS50290
Domain	EGF_CA	FAT4 EGF LRP2 C1S	4.35e-03	122	101	4	SM00179
Domain	EGF-like_Ca-bd_dom	FAT4 EGF LRP2 C1S	4.60e-03	124	101	4	IPR001881
Pathway	BIOCARTA_DICER_PATHWAY	AGO2 AGO1 AGO4	1.22e-06	5	71	3	M22079
Pathway	REACTOME_MICRORNA_MIRNA_BIOGENESIS	AGO2 AGO1 AGO4	2.42e-06	6	71	3	MM14818
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	AGO2 AGO1 AGO4	2.42e-06	6	71	3	MM15083
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	AGO2 AGO1 AGO4	4.22e-06	7	71	3	M46421
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	AGO2 AGO1 AGO4	6.73e-06	8	71	3	MM15082
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	AGO2 AGO1 AGO4	1.01e-05	9	71	3	M27340
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	AGO2 AGO1 AGO4	1.01e-05	9	71	3	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	AGO2 AGO1 AGO4	1.01e-05	9	71	3	M46436
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	AGO2 AGO1 AGO4	1.43e-05	10	71	3	M48013
Pathway	REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION	AGO2 AGO1 AGO4	3.38e-05	13	71	3	M46434
Pathway	REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY	AGO2 AGO1 AGO4	7.91e-05	17	71	3	M27788
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS	AGO2 AGO1 AGO4	1.12e-04	19	71	3	M48238
Pathway	REACTOME_MICRORNA_MIRNA_BIOGENESIS	AGO2 AGO1 AGO4	2.60e-04	25	71	3	M712
Pathway	REACTOME_TGFBR3_EXPRESSION	AGO2 AGO1 AGO4	3.66e-04	28	71	3	M48253
Pathway	REACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION	AGO2 AGO1 AGO4	5.47e-04	32	71	3	M48012
Pathway	REACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY	AGO2 AGO1 AGO4	5.47e-04	32	71	3	M27900
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4	AGO2 AGO1 AGO4	6.55e-04	34	71	3	M46422
Pathway	REACTOME_NUCLEAR_EVENTS_STIMULATED_BY_ALK_SIGNALING_IN_CANCER	AGO2 AGO1 AGO4	7.14e-04	35	71	3	M42525
Pathway	REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX	AGO2 AGO1 AGO4	8.41e-04	37	71	3	M29790
Pathway	REACTOME_TP53_REGULATES_METABOLIC_GENES	AGO2 AGO1 AGO4 MTOR	8.41e-04	84	71	4	M27495
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HIVEP2 KDM5A BAG3 MAP3K20 PARD3B STIL MTOR PLEKHG3 STARD9 SIPA1L1 TET1 ANKRD17 HELZ CNOT4 SEC23B DOP1A	9.22e-09	861	107	16	36931259
Pubmed	Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins.	AGO2 AGO1 AGO4	2.83e-08	3	107	3	19946268
Pubmed	Molecular dissection of human Argonaute proteins by DNA shuffling.	AGO2 AGO1 AGO4	1.13e-07	4	107	3	23748378
Pubmed	Slicing-independent RISC activation requires the argonaute PAZ domain.	AGO2 AGO1 AGO4	1.13e-07	4	107	3	22795694
Pubmed	Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.	AGO2 AGO1 AGO4	1.13e-07	4	107	3	18771919
Pubmed	Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.	AGO2 AGO1 AGO4	1.13e-07	4	107	3	15260970
Pubmed	ATP-dependent human RISC assembly pathways.	AGO2 AGO1 AGO4	1.13e-07	4	107	3	19966796
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	AGO2 AGO1 AGO4 ANKRD17 HELZ CNOT4	1.84e-07	80	107	6	35803934
Pubmed	Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.	AGO2 AGO1 AGO4	2.82e-07	5	107	3	19393748
Pubmed	The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.	AGO2 AGO1 AGO4	2.82e-07	5	107	3	12414724
Pubmed	The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.	AGO2 AGO1 AGO4	2.82e-07	5	107	3	19324964
Pubmed	Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.	AGO2 AGO1 AGO4	2.82e-07	5	107	3	12526743
Pubmed	Differential expression of components of the microRNA machinery during mouse organogenesis.	AGO2 AGO1 AGO4	2.82e-07	5	107	3	16036130
Pubmed	Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.	AGO2 AUP1 MAPKAPK5 MTOR BAG6	6.40e-07	53	107	5	35216969
Pubmed	Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development.	AGO2 AGO1 AGO4	9.82e-07	7	107	3	34907157
Pubmed	Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.	AGO2 AGO1 AGO4	9.82e-07	7	107	3	19536157
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	AGO2 AGO1 AGO4	9.82e-07	7	107	3	19383768
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	AGO2 AGO1 AGO4	9.82e-07	7	107	3	19470757
Pubmed	Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis.	AGO2 AGO1 AGO4	1.57e-06	8	107	3	19345100
Pubmed	Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis.	AGO2 AGO1 AGO4	1.57e-06	8	107	3	29021386
Pubmed	Identification of eight members of the Argonaute family in the human genome.	AGO2 AGO1 AGO4	2.35e-06	9	107	3	12906857
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	BCKDHA BCKDHB ZFC3H1 SIPA1L1 ANKRD17 HELZ BAG6	4.41e-06	212	107	7	33853758
Pubmed	Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.	THOC1 CACNA1C FAT4	4.59e-06	11	107	3	20351715
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	AGO2 SGIP1 CAT BCKDHA CDKL5 STARD9 SIPA1L1 KCTD3 GABBR1	7.65e-06	430	107	9	32581705
Pubmed	Reduced Expression of Argonaute 1, Argonaute 2, and TRBP Changes Levels and Intracellular Distribution of RNAi Factors.	AGO2 AGO1	9.38e-06	2	107	2	26242502
Pubmed	Molecular genetic analysis of MSUD from India reveals mutations causing altered protein truncation affecting the C-termini of E1α and E1β.	BCKDHA BCKDHB	9.38e-06	2	107	2	22593002
Pubmed	The Importance of AGO 1 and 4 in Post-Transcriptional Gene Regulatory Function of tRF5-GluCTC, an Respiratory Syncytial Virus-Induced tRNA-Derived RNA Fragment.	AGO1 AGO4	9.38e-06	2	107	2	33233493
Pubmed	Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.	MTOR PIK3CG	9.38e-06	2	107	2	20166697
Pubmed	Interaction between DISC1 and CHL1 in regulation of neurite outgrowth.	CHL1 DISC1	9.38e-06	2	107	2	27346367
Pubmed	Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase.	BCKDHA BCKDHB	9.38e-06	2	107	2	15166214
Pubmed	Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support.	MTOR PIK3CG	9.38e-06	2	107	2	15496972
Pubmed	Pro-angiogenic effect of IFNgamma is dependent on the PI3K/mTOR/translational pathway in human retinal pigmented epithelial cells.	MTOR PIK3CG	9.38e-06	2	107	2	20157617
Pubmed	Congenital dyserythropoietic anemia in China: a case report from two families and a review.	CDAN1 SEC23B	9.38e-06	2	107	2	24196372
Pubmed	Involvement of AGO1 and AGO2 in mammalian transcriptional silencing.	AGO2 AGO1	9.38e-06	2	107	2	16936728
Pubmed	Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.	AGO2 AGO1	9.38e-06	2	107	2	10534406
Pubmed	Argonaute Family Protein Expression in Normal Tissue and Cancer Entities.	AGO2 AGO1	9.38e-06	2	107	2	27518285
Pubmed	Impaired assembly of E1 decarboxylase of the branched-chain alpha-ketoacid dehydrogenase complex in type IA maple syrup urine disease.	BCKDHA BCKDHB	9.38e-06	2	107	2	9582350
Pubmed	Four novel mutations of the BCKDHA, BCKDHB and DBT genes in Iranian patients with maple syrup urine disease.	BCKDHA BCKDHB	9.38e-06	2	107	2	29306928
Pubmed	Heterogeneity of mutations in maple syrup urine disease (MSUD): screening and identification of affected E1 alpha and E1 beta subunits of the branched-chain alpha-keto-acid dehydrogenase multienzyme complex.	BCKDHA BCKDHB	9.38e-06	2	107	2	8161368
Pubmed	Association of Polymorphic Variants in Argonaute Genes with Depression Risk in a Polish Population.	AGO2 AGO1	9.38e-06	2	107	2	36142498
Pubmed	Polymorphisms and expression of genes encoding Argonautes 1 and 2 in autoimmune thyroid diseases.	AGO2 AGO1	9.38e-06	2	107	2	29256262
Pubmed	Argonaute proteins couple chromatin silencing to alternative splicing.	AGO2 AGO1	9.38e-06	2	107	2	22961379
Pubmed	Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation.	LGR5 TET1	9.38e-06	2	107	2	27856615
Pubmed	Eleven novel mutations of the BCKDHA, BCKDHB and DBT genes associated with maple syrup urine disease in the Chinese population: Report on eight cases.	BCKDHA BCKDHB	9.38e-06	2	107	2	26453840
Pubmed	Leucine-induced activation of translational initiation is partly regulated by the branched-chain alpha-keto acid dehydrogenase complex in C2C12 cells.	BCKDHA BCKDHB	9.38e-06	2	107	2	16581023
Pubmed	Association study of AGO1 and AGO2 genes polymorphisms with recurrent pregnancy loss.	AGO2 AGO1	9.38e-06	2	107	2	31666609
Pubmed	Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease.	BCKDHA BCKDHB	9.38e-06	2	107	2	10745006
Pubmed	Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins.	AGO2 AGO1	9.38e-06	2	107	2	23019594
Pubmed	Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin.	MTOR GRHL3	9.38e-06	2	107	2	29238073
Pubmed	Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma.	AGO2 AGO1	9.38e-06	2	107	2	22858679
Pubmed	Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.	AGO2 AGO1	9.38e-06	2	107	2	12230974
Pubmed	Effects of Echinococcus multilocularis miR-71 mimics on murine macrophage RAW264.7 cells.	AGO1 AGO4	9.38e-06	2	107	2	26995025
Pubmed	Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site.	BCKDHA BCKDHB	9.38e-06	2	107	2	12902323
Pubmed	mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.	LGR5 MTOR	9.38e-06	2	107	2	27538837
Pubmed	Clinical characteristics and mutation analysis of five Chinese patients with maple syrup urine disease.	BCKDHA BCKDHB	9.38e-06	2	107	2	29307017
Pubmed	mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer.	AGO2 AGO1	9.38e-06	2	107	2	19723326
Pubmed	Evaluation of Argonaute protein as a predictive marker for human clear cell renal cell carcinoma.	AGO2 AGO1	9.38e-06	2	107	2	23696926
Pubmed	Ago1 and Ago2 differentially affect cell proliferation, motility and apoptosis when overexpressed in SH-SY5Y neuroblastoma cells.	AGO2 AGO1	9.38e-06	2	107	2	21846468
Pubmed	The association of AGO1 (rs595961G>A, rs636832A>G) and AGO2 (rs11996715C>A, rs2292779C>G, rs4961280C>A) polymorphisms and risk of recurrent implantation failure.	AGO2 AGO1	9.38e-06	2	107	2	31724726
Pubmed	Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs.	AGO2 AGO1 AGO4	1.54e-05	16	107	3	20102707
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	RPF1 SGIP1 DISC1 STIL QSOX1 AGO1 MTOR KCTD3 ERMAP GRHL3 CLSPN IL23R CA6	1.75e-05	1031	107	13	16710414
Pubmed	Turning catalytically inactive human Argonaute proteins into active slicer enzymes.	AGO2 AGO1	2.81e-05	3	107	2	23665583
Pubmed	The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.	MTOR PIK3CG	2.81e-05	3	107	2	19897009
Pubmed	Elevated phosphatidylinositol 3-kinase activation and its clinicopathological significance in cervical cancer.	MTOR PIK3CG	2.81e-05	3	107	2	18395956
Pubmed	Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder.	MTOR PIK3CG	2.81e-05	3	107	2	21707707
Pubmed	The roles of individual mammalian argonautes in RNA interference in vivo.	AGO2 AGO1	2.81e-05	3	107	2	24992693
Pubmed	Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.	MTOR PIK3CG	2.81e-05	3	107	2	19078992
Pubmed	Three novel mutations of the BCKDHA, BCKDHB and DBT genes in Chinese children with maple syrup urine disease.	BCKDHA BCKDHB	2.81e-05	3	107	2	34883003
Pubmed	Molecular and structural analyses of maple syrup urine disease and identification of a founder mutation in a Portuguese Gypsy community.	BCKDHA BCKDHB	2.81e-05	3	107	2	18378174
Pubmed	Identification of CDAN1, C15ORF41 and SEC23B mutations in Chinese patients affected by congenital dyserythropoietic anemia.	CDAN1 SEC23B	2.81e-05	3	107	2	29031773
Pubmed	Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation.	BCKDHA BCKDHB	2.81e-05	3	107	2	15576032
Pubmed	Maple Syrup Urine Disease	BCKDHA BCKDHB	2.81e-05	3	107	2	20301495
Pubmed	Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice.	BCKDHA BCKDHB	2.81e-05	3	107	2	16875466
Pubmed	Ago1 Interacts with RNA polymerase II and binds to the promoters of actively transcribed genes in human cancer cells.	AGO2 AGO1	2.81e-05	3	107	2	24086155
Pubmed	Description of the mutations in 15 subjects with variant forms of maple syrup urine disease.	BCKDHA BCKDHB	2.81e-05	3	107	2	17922217
Pubmed	Molecular genetics of maple syrup urine disease in the Turkish population.	BCKDHA BCKDHB	2.81e-05	3	107	2	19480318
Pubmed	Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.	MAPKAPK5 MTOR	2.81e-05	3	107	2	21336308
Pubmed	Association of BCAT2 and BCKDH polymorphisms with clinical, anthropometric and biochemical parameters in young adults.	BCKDHA BCKDHB	2.81e-05	3	107	2	34511290
Pubmed	Argonaute2 is the catalytic engine of mammalian RNAi.	AGO2 AGO1	2.81e-05	3	107	2	15284456
Pubmed	Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.	AGO2 AGO1	2.81e-05	3	107	2	30201950
Pubmed	Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck.	MTOR PIK3CG	2.81e-05	3	107	2	19615795
Pubmed	The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine.	THOC1 LGR5	2.81e-05	3	107	2	23816884
Pubmed	Genetic variations of the PI3K-AKT-mTOR pathway and clinical outcome in muscle invasive and metastatic bladder cancer patients.	MTOR PIK3CG	2.81e-05	3	107	2	20530239
Pubmed	A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway.	AGO2 AGO1	2.81e-05	3	107	2	17626790
Pubmed	Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.	MTOR PIK3CG	2.81e-05	3	107	2	24008870
Pubmed	Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer.	MTOR PIK3CG	2.81e-05	3	107	2	18652687
Pubmed	Differential processing of human and rat E1 alpha precursors of the branched-chain alpha-keto acid dehydrogenase complex caused by an N-terminal proline in the rat sequence.	BCKDHA BCKDHB	2.81e-05	3	107	2	7918575
Pubmed	Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies.	AGO2 AGO1	2.81e-05	3	107	2	15908945
Pubmed	Controversies in breast cancer: the mammalian target of rapamycin as a target for breast cancer therapy.	MTOR PIK3CG	2.81e-05	3	107	2	20030877
Pubmed	Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.	MTOR PIK3CG	2.81e-05	3	107	2	15001544
Pubmed	Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts.	CDAN1 SEC23B	2.81e-05	3	107	2	21364188
Pubmed	Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling.	MTOR PIK3CG	2.81e-05	3	107	2	20488790
Pubmed	A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.	AGO2 AGO1	2.81e-05	3	107	2	17891150
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	AGO2 KDM5A ACTR5 BCKDHA BCKDHB TRMT2A KMT5B SIPA1L1 LRP2 ANKRD17 HELZ CHPF2 CLSPN	3.97e-05	1116	107	13	31753913
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	CHL1 KMT2C SIPA1L1 LRP2 ANKRD17 DOP1A	4.66e-05	208	107	6	33230847
Pubmed	mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.	MTOR SIPA1L1 CLSPN	4.79e-05	23	107	3	22017875
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	SGIP1 DISC1 LGR5 MAPKAPK5 PKHD1L1 TMEM87A NUDT12 STARD9 KCTD3 ERMAP	5.27e-05	686	107	10	29987050
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	AUP1 KDM5A ACTR5 RBM33 MAP3K20 DIDO1 ZFC3H1 KMT2C PLEKHG3 SIPA1L1 KCTD3 ANKRD17 CRYBG1 HELZ POLR1B	5.49e-05	1497	107	15	31527615
Pubmed	Molecular and phenotypic characteristics of seven novel mutations causing branched-chain organic acidurias.	BCKDHA BCKDHB	5.60e-05	4	107	2	26830710
Pubmed	Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression.	AGO2 AGO1	5.60e-05	4	107	2	20671708
Interaction	TNRC6C interactions	AGO2 STIL AGO1 AGO4 ANKRD17 HELZ SEC23B	7.40e-06	138	104	7	int:TNRC6C
Interaction	TNRC6A interactions	AGO2 STIL KMT2C AGO1 AGO4 ANKRD17 HELZ CNOT4 SEC23B	1.47e-05	280	104	9	int:TNRC6A
Interaction	TNRC6B interactions	AGO2 STIL AGO1 AGO4 LATS2 ANKRD17 HELZ CNOT4 SEC23B	1.56e-05	282	104	9	int:TNRC6B
Interaction	UBAP2L interactions	AGO2 DISC1 BAG3 CDKL5 AGO1 MTOR ANKRD17 HELZ CNOT4	2.41e-05	298	104	9	int:UBAP2L
Interaction	CA6 interactions	BCKDHA IDUA QSOX1 TRMT2A CA6	2.87e-05	69	104	5	int:CA6
GeneFamily	Argonaute/PIWI family	AGO2 AGO1 AGO4	2.57e-06	8	66	3	408
GeneFamily	BCL2 associated athanogene family	BAG3 BAG6	1.95e-04	6	66	2	1139
GeneFamily	Dyneins, axonemal	DNAH10 DNAI1	1.72e-03	17	66	2	536
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	HIVEP2 AGO2 KDM5A DIDO1 ZFC3H1 MTMR6 HELZ CNOT4 DOP1A	3.44e-06	300	105	9	M8702
Coexpression	GSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_24H_CD4_TCELL_UP	RBM33 BAG3 CPNE5 XYLT1 CRYBG1 HELZ GABBR1	1.39e-05	195	105	7	M4195
ToppCell	CV-Mild-7\|CV / Virus stimulation, Condition and Cluster	HDX STIL XYLT1 CDKL5 ZNF606 DOP1A	3.51e-06	170	107	6	25ebde7d2f8ae1afdfaf5876284ff20bb179eb10
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C FAT4 SGIP1 LGR5 KIAA1755 C1S	8.17e-06	197	107	6	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CHL1 AHI1 GDF10 XYLT1 KIAA1755 C1S	8.66e-06	199	107	6	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C FAT4 SGIP1 GDF10 STARD9 C1S	8.91e-06	200	107	6	3dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	ZNF174 DISC1 NUDT12 SUOX IL23R	2.92e-05	148	107	5	80470353e12599440f711b6e107730763376d04d
ToppCell	356C-Lymphocytic-ILC-ILC-2\|356C / Donor, Lineage, Cell class and subclass (all cells)	BCKDHA DNAAF9 IDUA POLR1B ZNF606	3.64e-05	155	107	5	0fd66c623cb433ceaa893bc21ba2e3b394faaf70
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAT CPNE5 NECAB1 SIPA1L1 POPDC3	5.05e-05	166	107	5	548d0d6c0ffd564036ddba78620734220ebb73d7
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAT CPNE5 NECAB1 SIPA1L1 POPDC3	5.05e-05	166	107	5	80e164a89d22098cabe4a99a78283ba69ea0561e
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ZNF174 DISC1 NUDT12 SUOX IL23R	6.14e-05	173	107	5	efb8072475000888efe088d00e870c56ffad4172
ToppCell	CV-Mild-7\|Mild / Virus stimulation, Condition and Cluster	HDX STIL XYLT1 CDKL5 DOP1A	6.14e-05	173	107	5	c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1C CHAT NECAB1 MTOR DOP1A	6.31e-05	174	107	5	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZNF174 DISC1 NUDT12 SUOX IL23R	6.31e-05	174	107	5	58300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 PKHD1L1 ITIH2 DNAI1 C12orf42	6.49e-05	175	107	5	f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCell	3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SGIP1 HDX GDF10 TET1 C1S	7.03e-05	178	107	5	09475e522dc1b8cf9ff1c25de5d1e3082b162948
ToppCell	3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SGIP1 HDX GDF10 TET1 C1S	7.03e-05	178	107	5	35de8f791b0e78a6caf52ff095f05e204a59e828
ToppCell	3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SGIP1 HDX GDF10 TET1 C1S	7.03e-05	178	107	5	000d25f3f13cc76cf39c46c312c6fafc2ea4f368
ToppCell	wk_08-11-Epithelial-PNS-Proliferating_Schwann\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CHL1 PCDHGC4 STIL C12orf42 KIAA1755	7.22e-05	179	107	5	ab23fee9adab1e63d5b5cd9faba6b9a92beef425
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	ZNF174 ARHGAP35 CDAN1 SUOX STARD9	7.22e-05	179	107	5	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C SGIP1 EBF2 XYLT1 STARD9	7.61e-05	181	107	5	451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C17orf99 CDAN1 FAM228B AGO4 NECAB1	7.61e-05	181	107	5	e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C17orf99 CDAN1 FAM228B AGO4 NECAB1	7.61e-05	181	107	5	d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP3K20 LGR5 GDF10 PLEKHG3 GRHL3	8.65e-05	186	107	5	e2ba9f3518d87a44537a57a648df17ab98fbbb39
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LGR5 GDF10 EBF2 C1S CRTAP	8.65e-05	186	107	5	c0a036096c2cb23305605b8aaf18869d6e0fb512
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP3K20 LGR5 GDF10 PLEKHG3 GRHL3	8.65e-05	186	107	5	fda3415222f688ef5cd8de4b0b79daa2493c585f
ToppCell	droplet-Liver-Npc-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LGR5 TMEM87A CDAN1 CLSPN CRTAP	8.65e-05	186	107	5	75258d88e23112fd1f0f7c71ef0366abb400d33e
ToppCell	Adult-Mesenchymal-pericyte_cell\|Adult / Lineage, Cell type, age group and donor	CACNA1C SGIP1 XYLT1 PLEKHG3 STARD9	8.87e-05	187	107	5	62759efb660179402fb574ce5701c89a2e17bcfe
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDF10 PKHD1L1 EBF2 LRP2 C1S	8.87e-05	187	107	5	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDF10 PKHD1L1 EBF2 LRP2 C1S	8.87e-05	187	107	5	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDF10 PKHD1L1 EBF2 LRP2 C1S	8.87e-05	187	107	5	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GDF10 EBF2 NUDT12 KIAA1755 C1S	8.87e-05	187	107	5	ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C SGIP1 EBF2 XYLT1 STARD9	9.09e-05	188	107	5	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AHI1 C17orf99 PKHD1L1 ERMAP CLSPN	9.32e-05	189	107	5	16dfc37d8d390ed7f927bc844c47c9c5a89a0928
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AHI1 C17orf99 PKHD1L1 ERMAP CLSPN	9.32e-05	189	107	5	3ade3fa9369e85304b20d7233b581f18ad5ecc89
ToppCell	droplet-Marrow-nan-24m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C17orf99 PKHD1L1 SUOX ERMAP CLSPN	9.32e-05	189	107	5	98ace332c3c046694c6ade47de8c8bf57ec51271
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHL1 CACNA1C XYLT1 KIAA1755 C1S	9.56e-05	190	107	5	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	droplet-Marrow-BM-1m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C17orf99 PKHD1L1 SUOX ERMAP CLSPN	9.80e-05	191	107	5	d78d4fbb0b8317dbf14e32182466a432abef3e93
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	KDM5A RBM33 PARD3B ZFC3H1 HELZ	1.00e-04	192	107	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHL1 CACNA1C XYLT1 KIAA1755 C1S	1.00e-04	192	107	5	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHL1 CACNA1C GDF10 XYLT1 C1S	1.00e-04	192	107	5	ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GDF10 EBF2 KIAA1755 C1S CRTAP	1.00e-04	192	107	5	19b94f254d51b9bda3d9b7c6f85e27ecb58409c8
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PARD3B DNAAF9 SIPA1L1 LRP2 ANKRD17	1.00e-04	192	107	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	KDM5A RBM33 PARD3B ZFC3H1 HELZ	1.03e-04	193	107	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	droplet-Mammary_Gland-nan-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM30B ITIH2 QSOX1 DNAI1 PLEKHG3	1.05e-04	194	107	5	715e02e5f3250b1bfdc26b7dfd656ba4e705ea84
ToppCell	severe-B_cell\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CHL1 PARD3B CPNE5 PKHD1L1 DOP1A	1.08e-04	195	107	5	0fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCell	COPD-Stromal-Myofibroblast\|COPD / Disease state, Lineage and Cell class	CACNA1C FAT4 SGIP1 GDF10 C1S	1.11e-04	196	107	5	af206bb5bbb8b604a6212acd79878bcc3d326cec
ToppCell	Parenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C SGIP1 EBF2 XYLT1 STARD9	1.13e-04	197	107	5	f66945f9007d59d4208849c7fd727f8519713fbc
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C FAT4 SGIP1 LGR5 GDF10	1.13e-04	197	107	5	0dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 SGIP1 MAP3K20 XYLT1 KIAA1755	1.13e-04	197	107	5	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	COPD-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	CACNA1C FAT4 SGIP1 GDF10 C1S	1.13e-04	197	107	5	d51f484b4e01ac64233950d0b97fa88825ea1dbb
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 SGIP1 MAP3K20 XYLT1 KIAA1755	1.13e-04	197	107	5	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	Parenchymal-NucSeq-Stromal-Pericyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C SGIP1 EBF2 XYLT1 STARD9	1.13e-04	197	107	5	41dd312f46a2b983c8d864adeb6970c0ca4a8048
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCKDHA GDF10 LATS2 STARD9 BAG6	1.13e-04	197	107	5	789c97ca9d1e28df3353140046047f11fbccc1d0
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	CACNA1C SGIP1 GDF10 KIAA1755 C1S	1.22e-04	200	107	5	4f7e26b27bd51c32420ed8c2f52d070aee542159
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C FAT4 SGIP1 STARD9 C1S	1.22e-04	200	107	5	b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C FAT4 SGIP1 STARD9 C1S	1.22e-04	200	107	5	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF569 GDF10 EBF2 C1S ZNF606	1.22e-04	200	107	5	8a4c210a3130f7baedf15ecbc0f4903b97da0352
Disease	Autistic Disorder	CACNA1C AHI1 DISC1 CAT AGO1 EGF PIK3CG GABBR1	4.48e-06	261	105	8	C0004352
Disease	Alcoholic Intoxication, Chronic	AGO2 SGIP1 BAG3 CAT AGO1 EGF GABBR1 IPO11	5.44e-06	268	105	8	C0001973
Disease	visceral adipose tissue measurement	CACNA1C HIVEP2 DNAH10 PARD3B EBF2 MTOR ERMAP C12orf42 CRYBG1 HELZ	8.74e-06	481	105	10	EFO_0004765
Disease	Intellectual Disability	CHL1 AHI1 HIVEP2 KDM5A DISC1 KMT2C AGO1 MTOR LRP2	3.23e-05	447	105	9	C3714756
Disease	pulse pressure measurement	SGIP1 KDM5A RBM33 CPNE5 GDF10 SNX19 EBF2 ARMS2 QSOX1 LATS2 TET1 SLX4IP KIAA1755 FER1L5 BAG6 ABCC10	3.28e-05	1392	105	16	EFO_0005763
Disease	sulfhydryl oxidase 1 measurement	QSOX1 C1S	3.75e-05	3	105	2	EFO_0802099
Disease	Maple syrup urine disease	BCKDHA BCKDHB	3.75e-05	3	105	2	cv:C0024776
Disease	Congenital dyserythropoietic anemia, type I	CDAN1 SEC23B	7.49e-05	4	105	2	C0271933
Disease	Congenital dyserythropoietic anemia, type II	CDAN1 SEC23B	7.49e-05	4	105	2	C1306589
Disease	Congenital dyserythropoietic anemia, type III	CDAN1 SEC23B	1.25e-04	5	105	2	C0271934
Disease	Congenital dyserythropoietic anemia	CDAN1 SEC23B	1.25e-04	5	105	2	C0002876
Disease	Intermediate Maple Syrup Urine Disease	BCKDHA BCKDHB	1.25e-04	5	105	2	C1621920
Disease	Classic Maple Syrup Urine Disease	BCKDHA BCKDHB	1.25e-04	5	105	2	C0268568
Disease	Intermittent Maple Syrup Urine Disease	BCKDHA BCKDHB	1.25e-04	5	105	2	C0268569
Disease	Maple Syrup Urine Disease, Thiamine Responsive	BCKDHA BCKDHB	1.25e-04	5	105	2	C0751285
Disease	maple syrup urine disease (is_implicated_in)	BCKDHA BCKDHB	1.25e-04	5	105	2	DOID:9269 (is_implicated_in)
Disease	adiponectin measurement	HIVEP2 DNAH10 MAP3K20 EGF GRHL3	1.80e-04	146	105	5	EFO_0004502
Disease	Congenital dyserythropoietic anemia	CDAN1 SEC23B	1.86e-04	6	105	2	cv:C0002876
Disease	Maple Syrup Urine Disease	BCKDHA BCKDHB	1.86e-04	6	105	2	C0024776
Disease	heart rate variability measurement	CPNE5 SIPA1L1 KIAA1755	3.12e-04	37	105	3	EFO_0008003
Disease	Disorder of amino acid metabolism	BCKDHA BCKDHB	3.46e-04	8	105	2	cv:C0002514
Disease	Neurodevelopmental Disorders	PARD3B CDKL5 KMT2C KMT5B	3.47e-04	93	105	4	C1535926
Disease	Antihypertensive use measurement	CACNA1C HIVEP2 BAG3 EBF2 ARMS2 ABCC10	3.80e-04	265	105	6	EFO_0009927
Disease	Mesothelioma	CAT GDF10 MTOR	4.23e-04	41	105	3	C0025500
Disease	pseudoxanthoma elasticum (is_implicated_in)	CAT XYLT1	4.44e-04	9	105	2	DOID:2738 (is_implicated_in)
Disease	cup-to-disc ratio measurement, optic cup area measurement, optic disc area measurement	MAP3K20 PLEKHG3	5.54e-04	10	105	2	EFO_0006937, EFO_0006939, EFO_0006940
Disease	blood copper measurement	MAPKAPK5 AGO4 CLSPN	7.60e-04	50	105	3	EFO_0007578
Disease	Carcinoma, Granular Cell	FAT4 KMT2C EGF MTOR	7.98e-04	116	105	4	C0205644
Disease	Adenocarcinoma, Tubular	FAT4 KMT2C EGF MTOR	7.98e-04	116	105	4	C0205645
Disease	Adenocarcinoma, Oxyphilic	FAT4 KMT2C EGF MTOR	7.98e-04	116	105	4	C0205642
Disease	Carcinoma, Cribriform	FAT4 KMT2C EGF MTOR	7.98e-04	116	105	4	C0205643
Disease	Adenocarcinoma, Basal Cell	FAT4 KMT2C EGF MTOR	7.98e-04	116	105	4	C0205641
Disease	Adenocarcinoma	FAT4 KMT2C EGF MTOR	7.98e-04	116	105	4	C0001418
Disease	sphingomyelin 18:1 measurement	CACNA1C PARD3B	9.54e-04	13	105	2	EFO_0010394
Disease	Fetal Alcohol Spectrum Disorders	CHL1 CAT	9.54e-04	13	105	2	C2985290
Disease	Schizophrenia	CHL1 CACNA1C AHI1 DISC1 CHAT TRMT2A MTOR TET1 LRP2 GABBR1	1.22e-03	883	105	10	C0036341
Disease	Profound Mental Retardation	CHL1 AHI1 KDM5A DISC1	1.56e-03	139	105	4	C0020796
Disease	Mental Retardation, Psychosocial	CHL1 AHI1 KDM5A DISC1	1.56e-03	139	105	4	C0025363
Disease	Mental deficiency	CHL1 AHI1 KDM5A DISC1	1.56e-03	139	105	4	C0917816
Disease	Fetal Alcohol Syndrome	CHL1 CAT	1.65e-03	17	105	2	C0015923
Disease	Major Depressive Disorder	CACNA1C DISC1 CAT EGF MTOR	1.80e-03	243	105	5	C1269683
Disease	Gastric ulcer	CAT EGF	1.85e-03	18	105	2	C0038358
Disease	Disorder of organic acid metabolism	BCKDHA BCKDHB	1.85e-03	18	105	2	cv:C1263739
Disease	schizophrenia (implicated_via_orthology)	HIVEP2 DISC1 MTOR	1.86e-03	68	105	3	DOID:5419 (implicated_via_orthology)
Disease	resting heart rate	CACNA1C SGIP1 CPNE5 KIAA1755	2.01e-03	149	105	4	EFO_0004351
Disease	ankylosing spondylitis (is_implicated_in)	KDM5A IL23R	2.06e-03	19	105	2	DOID:7147 (is_implicated_in)
Disease	Unipolar Depression	CACNA1C DISC1 CAT EGF MTOR	2.37e-03	259	105	5	C0041696
Disease	gastric ulcer (biomarker_via_orthology)	CAT IDUA	2.52e-03	21	105	2	DOID:10808 (biomarker_via_orthology)
Disease	Depression, Bipolar	CACNA1C DISC1 STARD9	2.85e-03	79	105	3	C0005587
Disease	electrocardiography	CACNA1C SGIP1 BAG3 ZFC3H1 LGR5 SIPA1L1 KIAA1755	2.91e-03	530	105	7	EFO_0004327
Disease	Alveolitis, Fibrosing	CAT EGF MTOR	3.27e-03	83	105	3	C4721507
Disease	Anhedonia	CACNA1C DISC1	3.29e-03	24	105	2	C0178417
Disease	Behcet Syndrome	CAT IL23R	3.29e-03	24	105	2	C0004943
Disease	stomach carcinoma (is_marker_for)	KDM5A KMT2C	3.29e-03	24	105	2	DOID:5517 (is_marker_for)
Disease	Pulmonary Fibrosis	CAT EGF MTOR	3.50e-03	85	105	3	C0034069

Protein segments in the cluster

Peptide	Gene	Start	Entry
FSPAGTQRRFQQPQH	ARMS2	81	P0C7Q2
RFPQISNSRHFITPN	FAM228B	196	P0C875
TNNADRFFRSHSSPP	CATSPER1	16	Q8NEC5
FPIEFNHRPLLSFQQ	CCIN	461	Q13939
FPSFIHSQKRNPQTH	CAT	161	P04040
QPLQRLQPQLRSFFH	BAG6	776	P46379
NNTNTFRVLPHPSFV	AHI1	686	Q8N157
PRFSQIFSAHVPENS	FAT4	2771	Q6V0I7
NVTRRPASHQTFPLQ	AGO1	281	Q9UL18
VFQTASQPSRPVHFQ	CCNJ	261	Q5T5M9
QPPSNLRKSNFFHFV	EBF2	56	Q9HAK2
PQVPTLHSQVFLFFR	DOP1A	2211	Q5JWR5
PFRSSFQVQLASNPV	ACTR5	516	Q9H9F9
FTRILTANNPHAPQN	DNAI1	66	Q9UI46
RRPASHQTFPLQLEN	AGO4	276	Q9HCK5
NFNRQHFSPLSLLTP	ANKRD17	2366	O75179
TQPLNHRVVESNFPN	CA6	266	P23280
HFQLPSRQPALSSFL	DISC1	391	Q9NRI5
AQAFFHNQPPSLRRT	CDAN1	851	Q8IWY9
RRPASHQTFPLQQES	AGO2	286	Q9UKV8
QFRPHVQTAQPQASS	RBM33	656	Q96EV2
FPGRPLVQNFLHSVN	QSOX1	341	O00391
AQRRQVAHFTFQPDP	BCKDHB	46	P21953
DSPATLRNQPHSLFQ	ABCC10	1461	Q5T3U5
DQHINFRSVTPARQP	PARD3B	686	Q8TEW8
ALTPRPIDNFSHNQS	KMT2C	2076	Q8NEZ4
NPLRSNFSPHFASSN	HDX	391	Q7Z353
VFANSVQFPHESSPR	MAPKAPK5	81	Q8IW41
VFPREISFTNLQPNH	CHL1	381	O00533
PLLRNVQFNYPHTSV	ITIH2	496	P19823
PVPSRTNSFNSHQPR	LATS2	401	Q9NRM7
QFDRTLHPRQSVFNI	MTMR6	501	Q9Y217
EHLLATTFFRQQPPR	KIAA1755	1151	Q5JYT7
NRQRFPTFFRTHPSA	GABBR1	276	Q9UBS5
LDQHPFSFTPLIQRS	IPO11	281	Q9UI26
SDSFSHNNPVRFRPI	KMT5B	116	Q4FZB7
PPTRQHLLFRSLSQN	GDF10	166	P55107
YVQSNHRTNAPFTPR	AK8	256	Q96MA6
PSDHQRAQINVPFLT	FAM205A	501	Q6ZU69
PSDHQRAQINVPFLT	FAM205BP	231	Q63HN1
QLIEFNPSHFQSAVP	MPP4	446	Q96JB8
GFLHTNFRFQPRVNP	FAM161B	356	Q96MY7
ENHSPPFQTINVERT	LRP2	2406	P98164
SDVNDNPPSFFQRSH	PCDHGC4	446	Q9Y5F7
FQRSHEVFVPENNRP	PCDHGC4	456	Q9Y5F7
FFNSAVAHRPQSPPA	HELZ	1431	P42694
IPFNRPRGHNFSLQT	HIPK3	66	Q9H422
GHLPSFQQSAFNRVV	KDM5A	1311	P29375
HRQPANFSFLPSQTS	C17orf99	176	Q6UX52
PVLFIPNVHFSSLQR	GRHL3	456	Q8TE85
FPQTFTTQRPLHINK	CACNA1C	1766	Q13936
PQPFLLFANSQDIRH	EGF	481	P01133
HFQPRPEAVQFFNVT	CRTAP	351	O75718
NPRLQKHPNFAFSVS	IL23R	521	Q5VWK5
HQPDNTAFTQQRLPA	TMEM30B	11	Q3MIR4
RSSNNPHSPIVEEFQ	C1S	86	P09871
NQFRPITPQVSFSAL	GJE1	66	A6NN92
SHITENSPNRQPFVL	DNAAF9	276	Q5TEA3
QFEDQRVHSPPRFTN	DIDO1	1966	Q9BTC0
HPHPFAQRTLTARFQ	IDUA	356	P35475
TARFQVNNTRPPHVQ	IDUA	366	P35475
RVSQSALNPHQSPDF	MAP3K20	716	Q9NYL2
PRRRNQIHLFSEPQF	CRYBG1	1411	Q9Y4K1
IHEQNVTRPAAQPSF	BAG3	211	O95817
VTRPAAQPSFHQAQK	BAG3	216	O95817
RQFPFLASIQNQGRH	AZU1	36	P20160
PRPDNSFHENNVSTR	CDKL5	721	O76039
QVFLPALSFNQHRTS	DNAH10	146	Q8IVF4
PQLFQTFTVHRSPVT	KCTD3	411	Q9Y597
PEIRRSPLTQHFQNS	POPDC3	271	Q9HBV1
PTNFAPVVTHVARNA	CPNE5	431	Q9HCH3
NPIQFVGRSAFQHLP	LGR5	291	O75473
SHPPRQQQQFSSLDD	BCKDHA	36	P12694
NTAIVITFGQHFRPF	NXPE1	431	Q8N323
RHITPFTSFQAVQPQ	MTOR	311	P42345
LRSPFPQRSQAVHIF	ERMAP	66	Q96PL5
TFRISPHAFFQVNTP	TRMT2A	401	Q8IZ69
FQGPFIRVVFLNHSQ	FER1L5	1096	A0AVI2
LFQAQPLSHRQPFIS	SPATA31A6	466	Q5VVP1
SPQRFFFNPSAVSQR	PLEKHG3	1011	A1L390
FFSNPAHPEFRVNLT	NEU1	331	Q99519
QPFSPKNIRSHFQHV	SIPA1L1	721	O43166
QQAFFVPPSRAIAHQ	NUDT12	436	Q9BQG2
PRVSSNLNLNNFPVH	STARD9	1536	Q9P2P6
DDQTFQPHRSTALQP	ARHGAP35	101	Q9NRY4
PQEHPFASSRFLQPV	SEC23B	221	Q15437
KQHRPSNAEFTRSNP	SLX4IP	61	Q5VYV7
PNRNHPTRLSLVFYQ	TET1	2036	Q8NFU7
PVNSSPAVIFARQHF	CHAT	211	P28329
VHFQEFNPALSPQRS	CHPF2	621	Q9P2E5
HFLNFPVFPERTQNS	C12orf42	81	Q96LP6
DHNPSAPRNSRNFVF	CLSPN	1271	Q9HAW4
APRNSRNFVFHTLSP	CLSPN	1276	Q9HAW4
VLPQRFPQFQQHRAV	CNOT4	471	O95628
QRHPRLRPQSAQSSF	AUP1	271	Q9Y679
HPPSEESQAFQRQLT	PIK3CG	141	P48736
LFPHNPQFIGRQVAT	RPF1	266	Q9H9Y2
RQSSLAPQSQPHDFV	STIL	561	Q15468
PQDFHRFQQTARPTF	XYLT1	581	Q86Y38
RRQVSSPNAQKPFAH	ZNF174	261	Q15697
HFANNPSPAALTFRV	SGIP1	601	Q9BQI5
SVSFHRLAFNQPSPV	PKHD1L1	2841	Q86WI1
NNSSHFLQPNVRGPL	SNX19	351	Q92543
NVFPLNSDFFPSRHN	ZNF569	121	Q5MCW4
PGNHSTSQEIFRQRF	ZNF232	41	Q9UNY5
NYITPNPIFFTRNHL	SUOX	206	P51687
ANFIPFSDHNQSPRN	POLR1B	671	Q9H9Y6
FSHLPLHSQQQVRAP	HIVEP2	2211	P31629
NTVSQPRIQNPKFHR	ZFC3H1	676	O60293
RPSANNQRFAFSPLS	TMEM87A	461	Q8NBN3
ARRSPHFFQPTNQQF	THOC1	501	Q96FV9
FNQSPSFNEHPRLHV	ZNF606	326	Q8WXB4
RVQRHNSFSPNSPQF	NECAB1	186	Q8N987