Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	NPBWR1 NPBWR2 CYSLTR2 UTS2R AGTR1 SSTR1 SSTR4	4.50e-08	133	51	7	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	NPBWR1 NPBWR2 CYSLTR2 UTS2R AGTR1 SSTR1 SSTR4	6.41e-08	140	51	7	GO:0001653
GeneOntologyMolecularFunction	neuropeptide binding	NPBWR1 NPBWR2 SSTR1 SSTR4	2.34e-06	37	51	4	GO:0042923
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	NPBWR1 NPBWR2 CYSLTR2 UTS2R EFEMP1 GPR61 CHRNA9 OR5V1 FFAR1 ROR2 AGTR1 P2RY8 SSTR1 SSTR4	4.83e-06	1353	51	14	GO:0004888
GeneOntologyMolecularFunction	neuropeptide receptor activity	NPBWR1 NPBWR2 SSTR1 SSTR4	1.01e-05	53	51	4	GO:0008188
GeneOntologyMolecularFunction	G protein-coupled receptor activity	NPBWR1 NPBWR2 CYSLTR2 UTS2R GPR61 OR5V1 FFAR1 AGTR1 P2RY8 SSTR1 SSTR4	1.13e-05	884	51	11	GO:0004930
GeneOntologyMolecularFunction	somatostatin receptor activity	SSTR1 SSTR4	6.36e-05	5	51	2	GO:0004994
GeneOntologyMolecularFunction	G protein-coupled opioid receptor activity	NPBWR1 NPBWR2	1.33e-04	7	51	2	GO:0004985
GeneOntologyMolecularFunction	RNA 7-methylguanosine cap binding	CYFIP1 CYFIP2	5.71e-04	14	51	2	GO:0000340
GeneOntologyMolecularFunction	RNA cap binding	CYFIP1 CYFIP2	1.30e-03	21	51	2	GO:0000339
GeneOntologyMolecularFunction	protein tyrosine phosphatase activity	TPTE2 CDC14B CDC14A	2.32e-03	103	51	3	GO:0004725
GeneOntologyBiologicalProcess	neuropeptide signaling pathway	NPBWR1 NPBWR2 CYSLTR2 UTS2R SSTR1 SSTR4	5.35e-07	124	50	6	GO:0007218
GeneOntologyBiologicalProcess	somatostatin receptor signaling pathway	SSTR1 SSTR4	8.59e-05	6	50	2	GO:0038169
GeneOntologyBiologicalProcess	somatostatin signaling pathway	SSTR1 SSTR4	8.59e-05	6	50	2	GO:0038170
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	NPBWR1 NPBWR2 CYSLTR2 UTS2R GPR61 OR5V1 FFAR1 ENTPD1 AGTR1 P2RY8 SSTR1 SSTR4	9.54e-05	1395	50	12	GO:0007186
GeneOntologyBiologicalProcess	positive regulation of neurotrophin TRK receptor signaling pathway	CYFIP1 CYFIP2	1.60e-04	8	50	2	GO:0051388
Domain	GPCR_Rhodpsn_7TM	NPBWR1 NPBWR2 CYSLTR2 UTS2R GPR61 OR5V1 FFAR1 AGTR1 P2RY8 SSTR1 SSTR4	9.80e-07	670	49	11	IPR017452
Domain	7tm_1	NPBWR1 NPBWR2 CYSLTR2 UTS2R GPR61 OR5V1 FFAR1 AGTR1 P2RY8 SSTR1 SSTR4	1.09e-06	677	49	11	PF00001
Domain	G_PROTEIN_RECEP_F1_1	NPBWR1 NPBWR2 CYSLTR2 UTS2R GPR61 OR5V1 FFAR1 AGTR1 P2RY8 SSTR1 SSTR4	1.22e-06	685	49	11	PS00237
Domain	G_PROTEIN_RECEP_F1_2	NPBWR1 NPBWR2 CYSLTR2 UTS2R GPR61 OR5V1 FFAR1 AGTR1 P2RY8 SSTR1 SSTR4	1.33e-06	691	49	11	PS50262
Domain	GPCR_Rhodpsn	NPBWR1 NPBWR2 CYSLTR2 UTS2R GPR61 OR5V1 FFAR1 AGTR1 P2RY8 SSTR1 SSTR4	1.34e-06	692	49	11	IPR000276
Domain	Cytoplasmic_FMR1-int	CYFIP1 CYFIP2	6.74e-06	2	49	2	IPR008081
Domain	FragX_IP	CYFIP1 CYFIP2	6.74e-06	2	49	2	PF05994
Domain	DSPn	CDC14B CDC14A	6.74e-06	2	49	2	PF14671
Domain	Neuropept_B/W_rcpt	NPBWR1 NPBWR2	6.74e-06	2	49	2	IPR009150
Domain	DSPn	CDC14B CDC14A	6.74e-06	2	49	2	IPR029260
Domain	MAM_1	MEP1B ZAN MDGA2	9.28e-06	16	49	3	PS00740
Domain	MAM	MEP1B ZAN MDGA2	1.12e-05	17	49	3	SM00137
Domain	MAM	MEP1B ZAN MDGA2	1.35e-05	18	49	3	PF00629
Domain	MAM_dom	MEP1B ZAN MDGA2	1.35e-05	18	49	3	IPR000998
Domain	MAM_2	MEP1B ZAN MDGA2	1.35e-05	18	49	3	PS50060
Domain	TILa	ZAN TECTA	2.02e-05	3	49	2	PF12714
Domain	TILa_dom	ZAN TECTA	2.02e-05	3	49	2	IPR025615
Domain	EGF	MEP1B CNTNAP5 EFEMP1 ZAN HYAL1 TECTA	3.31e-05	235	49	6	SM00181
Domain	DUF1394	CYFIP1 CYFIP2	4.03e-05	4	49	2	PF07159
Domain	DUF1394	CYFIP1 CYFIP2	4.03e-05	4	49	2	IPR009828
Domain	EGF-like_dom	MEP1B CNTNAP5 EFEMP1 ZAN HYAL1 TECTA	4.57e-05	249	49	6	IPR000742
Domain	Somatstn_rcpt	SSTR1 SSTR4	6.71e-05	5	49	2	IPR000586
Domain	Dual-sp_phosphatase_cat-dom	TPTE2 CDC14B CDC14A	1.69e-04	41	49	3	IPR000340
Domain	DSPc	TPTE2 CDC14B CDC14A	1.69e-04	41	49	3	PF00782
Domain	7TM_GPCR_Srsx	NPBWR2 AGTR1 SSTR1 SSTR4	2.11e-04	112	49	4	SM01381
Domain	EGF_3	MEP1B CNTNAP5 EFEMP1 ZAN HYAL1	3.67e-04	235	49	5	PS50026
Domain	TIL	ZAN TECTA	4.38e-04	12	49	2	PF01826
Domain	C8	ZAN TECTA	4.38e-04	12	49	2	PF08742
Domain	Unchr_dom_Cys-rich	ZAN TECTA	5.16e-04	13	49	2	IPR014853
Domain	C8	ZAN TECTA	5.16e-04	13	49	2	SM00832
Domain	EGF_1	MEP1B CNTNAP5 EFEMP1 ZAN HYAL1	5.33e-04	255	49	5	PS00022
Domain	TIL_dom	ZAN TECTA	6.01e-04	14	49	2	IPR002919
Domain	EGF_2	MEP1B CNTNAP5 EFEMP1 ZAN HYAL1	6.34e-04	265	49	5	PS01186
Domain	VWFD	ZAN TECTA	7.90e-04	16	49	2	PS51233
Domain	VWD	ZAN TECTA	7.90e-04	16	49	2	SM00216
Domain	VWF_type-D	ZAN TECTA	7.90e-04	16	49	2	IPR001846
Domain	VWD	ZAN TECTA	7.90e-04	16	49	2	PF00094
Domain	Tyr_Pase_AS	TPTE2 CDC14B CDC14A	9.28e-04	73	49	3	IPR016130
Domain	VWC_out	ZAN TECTA	1.12e-03	19	49	2	SM00215
Domain	TYR_PHOSPHATASE_1	TPTE2 CDC14B CDC14A	1.49e-03	86	49	3	PS00383
Domain	TYR_PHOSPHATASE_2	TPTE2 CDC14B CDC14A	1.54e-03	87	49	3	PS50056
Domain	TYR_PHOSPHATASE_dom	TPTE2 CDC14B CDC14A	1.54e-03	87	49	3	IPR000387
Domain	-	TPTE2 CDC14B CDC14A	1.81e-03	92	49	3	3.90.190.10
Domain	Prot-tyrosine_phosphatase-like	TPTE2 CDC14B CDC14A	2.23e-03	99	49	3	IPR029021
Domain	ConA-like_dom	MEP1B CNTNAP5 ZAN MDGA2	2.58e-03	219	49	4	IPR013320
Domain	TYR_PHOSPHATASE_DUAL	CDC14B CDC14A	3.59e-03	34	49	2	PS50054
Domain	DSPc	CDC14B CDC14A	3.80e-03	35	49	2	SM00195
Domain	TYR_PHOSPHATASE_DUAL_dom	CDC14B CDC14A	3.80e-03	35	49	2	IPR020422
Domain	EGF	MEP1B ZAN TECTA	4.41e-03	126	49	3	PF00008
Domain	VWC	ZAN TECTA	4.46e-03	38	49	2	SM00214
Domain	VWFC_2	ZAN TECTA	4.46e-03	38	49	2	PS50184
Domain	EGF-like_CS	MEP1B EFEMP1 ZAN HYAL1	4.82e-03	261	49	4	IPR013032
Domain	PTPase_domain	CDC14B CDC14A	5.18e-03	41	49	2	IPR000242
Domain	Y_phosphatase	CDC14B CDC14A	5.18e-03	41	49	2	PF00102
Domain	VWF_dom	ZAN TECTA	5.43e-03	42	49	2	IPR001007
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	NPBWR1 NPBWR2 CYSLTR2 UTS2R CHRNA9 AGTR1 P2RY8 SSTR1 SSTR4	6.63e-08	272	41	9	M13380
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	NPBWR1 NPBWR2 CYSLTR2 OR5V1 FFAR1 AGTR1 SSTR1 SSTR4	6.78e-07	260	41	8	M39397
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	NPBWR1 NPBWR2 CYSLTR2 UTS2R FFAR1 AGTR1 SSTR1 SSTR4	4.04e-06	330	41	8	M18334
Pathway	WP_GPCRS_NONODORANT	NPBWR1 CYSLTR2 UTS2R FFAR1 AGTR1 SSTR1 SSTR4	1.02e-05	266	41	7	MM15843
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	NPBWR1 NPBWR2 UTS2R AGTR1 SSTR1 SSTR4	2.07e-05	197	41	6	M12289
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	NPBWR1 CYSLTR2 UTS2R FFAR1 AGTR1 SSTR1 SSTR4	4.34e-05	333	41	7	MM14963
Pathway	REACTOME_GPCR_LIGAND_BINDING	NPBWR1 NPBWR2 CYSLTR2 UTS2R FFAR1 AGTR1 SSTR1 SSTR4	4.69e-05	463	41	8	M507
Pathway	REACTOME_GPCR_LIGAND_BINDING	NPBWR1 CYSLTR2 UTS2R FFAR1 AGTR1 SSTR1 SSTR4	2.14e-04	430	41	7	MM15160
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	NPBWR1 UTS2R AGTR1 SSTR1 SSTR4	2.52e-04	197	41	5	MM14970
Pathway	REACTOME_SIGNALING_BY_GPCR	NPBWR1 NPBWR2 CYSLTR2 UTS2R FFAR1 AGTR1 SSTR1 SSTR4	8.05e-04	702	41	8	M746
Pathway	WP_GPCRS_PEPTIDE	AGTR1 SSTR1 SSTR4	1.09e-03	70	41	3	MM15959
Pathway	WP_PEPTIDE_GPCRS	AGTR1 SSTR1 SSTR4	1.33e-03	75	41	3	M39696
Pubmed	Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair.	CDC14B CDC14A	2.11e-06	2	51	2	20479464
Pubmed	The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.	NPBWR1 NPBWR2	2.11e-06	2	51	2	7590751
Pubmed	Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.	CDC14B CDC14A	2.11e-06	2	51	2	11901424
Pubmed	Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.	CYFIP1 CYFIP2	2.11e-06	2	51	2	38128786
Pubmed	Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.	CDC14B CDC14A	2.11e-06	2	51	2	33328327
Pubmed	Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.	CYFIP1 CYFIP2	2.11e-06	2	51	2	34327661
Pubmed	Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.	CDC14B CDC14A	2.11e-06	2	51	2	12134069
Pubmed	C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.	CYFIP1 CYFIP2	2.11e-06	2	51	2	24357318
Pubmed	Cytoplasmic FMRP interacting protein 1/2 (CYFIP1/2) expression analysis in autism.	CYFIP1 CYFIP2	2.11e-06	2	51	2	29752658
Pubmed	Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion.	CYFIP1 CYFIP2	2.11e-06	2	51	2	35567753
Pubmed	Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex.	CYFIP1 CYFIP2	2.11e-06	2	51	2	31324746
Pubmed	Functional homology among human and fission yeast Cdc14 phosphatases.	CDC14B CDC14A	2.11e-06	2	51	2	15911625
Pubmed	A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.	CDC14B CDC14A	6.32e-06	3	51	2	9367992
Pubmed	80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c.	STXBP3 PRKCSH	6.32e-06	3	51	2	19061073
Pubmed	Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.	NPBWR1 NPBWR2	6.32e-06	3	51	2	12130646
Pubmed	The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53.	CDC14B CDC14A	6.32e-06	3	51	2	10644693
Pubmed	Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.	CDC14B CDC14A	6.32e-06	3	51	2	26283732
Pubmed	Dissociation of heterotrimeric g proteins in cells.	NPBWR1 NPBWR2 AGTR1 SSTR1 SSTR4	6.62e-06	179	51	5	18577758
Pubmed	Retinoic acid deficiency impairs the vestibular function.	GLI3 ALDH1A3 TECTA	7.54e-06	26	51	3	23536097
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	NPBWR1 NPBWR2 AGTR1 SSTR1 SSTR4	1.13e-05	200	51	5	18240029
Pubmed	Molecular cloning and expression of a type-two somatostatin receptor in goldfish brain and pituitary.	SSTR1 SSTR4	1.26e-05	4	51	2	10996426
Pubmed	Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development.	CYFIP1 CYFIP2	1.26e-05	4	51	2	15294869
Pubmed	G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.	NPBWR1 NPBWR2	1.26e-05	4	51	2	15797961
Pubmed	CDC14A phosphatase is essential for hearing and male fertility in mouse and human.	CDC14B CDC14A	1.26e-05	4	51	2	29293958
Pubmed	Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth.	CYFIP1 CYFIP2	1.26e-05	4	51	2	27605705
Pubmed	Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking.	STXBP3 PRKCSH	1.26e-05	4	51	2	15707389
Pubmed	Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.	CYFIP1 CYFIP2	1.26e-05	4	51	2	20228810
Pubmed	Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.	NPBWR1 NPBWR2	1.26e-05	4	51	2	12719537
Pubmed	Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.	CDC14B CDC14A	1.26e-05	4	51	2	22784093
Pubmed	Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain.	SSTR1 SSTR4	1.26e-05	4	51	2	8405411
Pubmed	Somatostatin sst2 receptor knock-out mice: localisation of sst1-5 receptor mRNA and binding in mouse brain by semi-quantitative RT-PCR, in situ hybridisation histochemistry and receptor autoradiography.	SSTR1 SSTR4	2.10e-05	5	51	2	11897118
Pubmed	A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.	PKHD1 PRKCSH	2.10e-05	5	51	2	21685914
Pubmed	Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.	SSTR1 SSTR4	2.10e-05	5	51	2	12021920
Pubmed	Immunohistochemical detection and localization of somatostatin receptor subtypes in prostate tissue from patients with bladder outlet obstruction.	SSTR1 SSTR4	2.10e-05	5	51	2	18936524
Pubmed	C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis.	CDC14B CDC14A	2.10e-05	5	51	2	20236090
Pubmed	[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy].	SSTR1 SSTR4	2.10e-05	5	51	2	11753241
Pubmed	Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.	NPBWR1 NPBWR2	2.10e-05	5	51	2	12401809
Pubmed	Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.	SSTR1 SSTR4	2.10e-05	5	51	2	8449518
Pubmed	Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.	SSTR1 SSTR4	2.10e-05	5	51	2	9279525
Pubmed	An immunohistochemical investigation of the expression of somatostatin receptor subtypes - should therapeutic trials be performed to determine the efficacy of somatostatin analogs in treating advanced thyroid malignances?	SSTR1 SSTR4	2.10e-05	5	51	2	25962406
Pubmed	Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.	SSTR1 SSTR4	2.10e-05	5	51	2	11344221
Pubmed	Characterisation of [125I]-Tyr0DTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain.	SSTR1 SSTR4	2.10e-05	5	51	2	12759718
Pubmed	Acromegaly: correlation between expression of somatostatin receptor subtypes and response to octreotide-lar treatment.	SSTR1 SSTR4	2.10e-05	5	51	2	19330452
Pubmed	Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease.	SSTR1 SSTR4	2.10e-05	5	51	2	12414882
Pubmed	Interaction of brain somatostatin receptors with the PDZ domains of PSD-95.	SSTR1 SSTR4	2.10e-05	5	51	2	17950729
Pubmed	Prognostic Value of Somatostatin Receptor Subtypes in Pancreatic Neuroendocrine Tumors.	SSTR1 SSTR4	2.10e-05	5	51	2	26474434
Pubmed	Somatostatin receptor subtypes in human type 2 diabetic islets.	SSTR1 SSTR4	2.10e-05	5	51	2	20182388
Pubmed	Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors.	SSTR1 SSTR4	2.10e-05	5	51	2	20717067
Pubmed	Brain somatostatin receptors are up-regulated in somatostatin-deficient mice.	SSTR1 SSTR4	3.15e-05	6	51	2	12145348
Pubmed	Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus.	CYFIP1 CYFIP2	3.15e-05	6	51	2	31853374
Pubmed	Identification and characterization of a novel human cortistatin-like peptide.	SSTR1 SSTR4	3.15e-05	6	51	2	9125122
Pubmed	Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.	SSTR1 SSTR4	3.15e-05	6	51	2	9205124
Pubmed	A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.	CYFIP1 CYFIP2	3.15e-05	6	51	2	11438699
Pubmed	Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk.	SSTR1 SSTR4	3.15e-05	6	51	2	19423539
Pubmed	Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.	SSTR1 SSTR4	3.15e-05	6	51	2	1346068
Pubmed	Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.	ENTPD1 P2RY8	3.15e-05	6	51	2	11004484
Pubmed	Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.	SSTR1 SSTR4	4.41e-05	7	51	2	25149275
Pubmed	Smaller Body Size, Early Postnatal Lethality, and Cortical Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null Embryonic Mice.	CYFIP1 CYFIP2	4.41e-05	7	51	2	30687000
Pubmed	Null mutant mouse models of somatostatin and cortistatin, and their receptors.	SSTR1 SSTR4	4.41e-05	7	51	2	18206294
Pubmed	Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain.	SSTR1 SSTR4	4.41e-05	7	51	2	22581439
Pubmed	Angiotensin converting enzyme DD genotype is associated with hypertensive crisis.	AGTR1 RENBP	4.41e-05	7	51	2	12394950
Pubmed	Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2α phosphorylation via protein interactors and actin cytoskeleton.	CYFIP1 CYFIP2	7.54e-05	9	51	2	38981622
Pubmed	Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study.	SSTR1 SSTR4	9.42e-05	10	51	2	16214911
Pubmed	Abi1 is essential for the formation and activation of a WAVE2 signalling complex.	CYFIP1 CYFIP2	9.42e-05	10	51	2	15048123
Pubmed	CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage.	STXBP3 ATP11C PRKCSH STT3A	9.56e-05	162	51	4	32913203
Pubmed	Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure.	AGTR1 RENBP	1.15e-04	11	51	2	20486282
Pubmed	Deficiency of the neurodevelopmental disorder-associated gene Cyfip2 alters the retinal ganglion cell properties and visual acuity.	CYFIP1 CYFIP2	1.63e-04	13	51	2	34508581
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	CNTNAP5 GLI3 MDGA2 CYFIP2	2.11e-04	199	51	4	23382691
Pubmed	Analysis of several hundred genetic polymorphisms may improve assessment of the individual genetic burden for coronary artery disease.	AGTR1 RENBP	2.19e-04	15	51	2	12446192
Pubmed	The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.	PKHD1 PRKCSH	2.83e-04	17	51	2	16472605
Pubmed	In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.	CYFIP1 CYFIP2	3.18e-04	18	51	2	9463375
Pubmed	Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.	SSTR1 SSTR4	3.18e-04	18	51	2	20810604
Pubmed	Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells.	STXBP3 PRKCSH STT3A	3.19e-04	90	51	3	31280863
Pubmed	The Dkk1 dose is critical for eye development.	GLI3 ALDH1A3	3.55e-04	19	51	2	21539829
Pubmed	Stable association between G alpha(q) and phospholipase C beta 1 in living cells.	CYSLTR2 UTS2R AGTR1	3.74e-04	95	51	3	16754659
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	CYFIP1 STXBP3 ROR2 PRKCSH CYFIP2	3.77e-04	421	51	5	36976175
Pubmed	Fuz regulates craniofacial development through tissue specific responses to signaling factors.	GLI3 ROR2	3.94e-04	20	51	2	21935430
Pubmed	Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome.	GLI3 ROR2	4.35e-04	21	51	2	14745966
Pubmed	NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.	CYFIP1 CYFIP2	4.78e-04	22	51	2	21946561
Pubmed	Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia.	GLI3 PKHD1	4.78e-04	22	51	2	28432216
Pubmed	Primary cilia in murine palatal rugae development.	GLI3 ROR2	5.23e-04	23	51	2	31226309
Pubmed	Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs.	SSTR1 SSTR4	6.70e-04	26	51	2	9226367
Pubmed	MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation.	GLI3 AGTR1	7.78e-04	28	51	2	29879378
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	STXBP3 TPTE2 CCDC138 PRKCSH CDC14B CDC14A CYFIP2	8.10e-04	1049	51	7	27880917
Pubmed	22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development.	GLI3 ALDH1A3	8.35e-04	29	51	2	23077214
Pubmed	Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling.	GLI3 ALDH1A3	8.93e-04	30	51	2	16368932
Pubmed	Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.	PRR12 CYFIP1 CYFIP2	1.23e-03	143	51	3	32560809
Cytoband	Ensembl 112 genes in cytogenetic band chr14q21	MDGA2 SSTR1 SEC23A	1.77e-04	97	51	3	chr14q21
Cytoband	1p13.3	STXBP3 GPR61	2.71e-03	69	51	2	1p13.3
GeneFamily	CDC14 phosphatases	CDC14B CDC14A	2.05e-05	4	34	2	900
GeneFamily	Somatostatin receptors	SSTR1 SSTR4	3.42e-05	5	34	2	257
GeneFamily	Neuropeptide receptors	NPBWR1 NPBWR2	1.53e-04	10	34	2	854
GeneFamily	Actins\|Deafness associated genes	PNPT1 TECTA	1.91e-02	113	34	2	1152
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CNTNAP5 MDGA2 ALDH1A3 SSTR1 PHYHIPL CYFIP2	1.06e-07	199	51	6	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CNTNAP5 MDGA2 ALDH1A3 SSTR1 PHYHIPL CYFIP2	1.06e-07	199	51	6	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CNTNAP5 MDGA2 ALDH1A3 SSTR1 PHYHIPL CYFIP2	1.09e-07	200	51	6	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CNTNAP5 ZAN PKHD1 MDGA2 TECTA	1.17e-06	162	51	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Fgf10_(Lateral_dorsal_thalamic_nuclei_(LD))\|Thalamus / BrainAtlas - Mouse McCarroll V32	FFAR1 AGTR1 PKHD1	1.32e-05	40	51	3	c645fd6bebf8a6c5aa6ff9d40105a3d65695496b
ToppCell	COVID-19-kidney-Epithelial_Doublet\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CNTNAP5 CHRNA9 PKHD1 MDGA2	1.50e-05	130	51	4	1ff28e9d3dc9a791e07d815f8fbb48f75d3f275b
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTNAP5 PKHD1 MDGA2 TECTA	2.30e-05	145	51	4	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 CHRNA9 ROR2 PKHD1	3.38e-05	160	51	4	8590281165eab6514a9f6a022b900d4c222c1044
ToppCell	facs-Heart-LV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 GLI3 ROR2 MDGA2	4.18e-05	169	51	4	849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell	3'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EFEMP1 HYAL1 ENTPD1 RENBP	5.58e-05	182	51	4	82d6f72649c7dd4d64a84a9795edebdef2f285d6
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHISAL2B ALDH1A3 SSTR1 PHYHIPL	6.59e-05	190	51	4	e792e42fc49472eaf974eb0905819eb51a1da8e5
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 PKHD1 ETNK1 CYFIP2	6.73e-05	191	51	4	297bc79adc5fef211497819b4861b52cd26ac754
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 PKHD1 ETNK1 CYFIP2	6.73e-05	191	51	4	e1ec165ba6578cefd88895e7e183190e79f733a4
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHISAL2B ALDH1A3 SSTR1 PHYHIPL	6.87e-05	192	51	4	550a6574a93acadb43c449094565c73ca51a0c5c
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GLI3 ROR2 AGTR1 ALDH1A3	7.01e-05	193	51	4	261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCell	(5)_Fibroblast-J_(Lipofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	EFEMP1 GLI3 ROR2 ALDH1A3	7.44e-05	196	51	4	afa29399decd17fda7d63add5039ff778627ccc2
ToppCell	distal-mesenchymal-Lipofibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EFEMP1 GLI3 ROR2 ALDH1A3	7.58e-05	197	51	4	865010edcd7e3f79f505fcef7b33882095994aa8
ToppCell	distal-mesenchymal-Lipofibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EFEMP1 GLI3 ROR2 ALDH1A3	7.58e-05	197	51	4	ceb83bdef16b58ee16193413bfb006f7715728b2
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFEMP1 GLI3 ROR2 ALDH1A3	7.73e-05	198	51	4	c66097ae9ba0b50561083c423565665958ef0bb8
ToppCell	distal-Endothelial-Artery-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HYAL1 ENTPD1 SSTR1 FAM124B	7.73e-05	198	51	4	f284f59f4ebe55ee132eddfaa2f5d9ecb059654f
ToppCell	distal-1-Endothelial-Artery\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HYAL1 ENTPD1 SSTR1 FAM124B	7.89e-05	199	51	4	fd71d08f6de790a29c880d50d2ed0881952d7791
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CNTNAP5 ALDH1A3 SSTR1 CYFIP2	7.89e-05	199	51	4	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EFEMP1 ABRAXAS1 GLI3 ROR2	7.89e-05	199	51	4	a95aa72387c9558e0316898eaa9df4de8932af1b
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFEMP1 GLI3 ROR2 ALDH1A3	8.04e-05	200	51	4	d64895354218ebd0217011bae0967a6883bbd1cd
Disease	Hypermetropia, Myopia	BPTF PNPT1 CNTNAP5 EFEMP1 OR5V1 NT5DC1	9.04e-07	189	51	6	HP_0000540, HP_0000545
Disease	chromosome 15q11.2 deletion syndrome (implicated_via_orthology)	CYFIP1 CYFIP2	8.78e-06	3	51	2	DOID:0060393 (implicated_via_orthology)
Disease	refractive error	PNPT1 EFEMP1 OR5V1 FER1L4 ETNK1 NT5DC1	2.06e-05	326	51	6	MONDO_0004892
Disease	femoral hernia	PNPT1 EFEMP1	6.12e-05	7	51	2	EFO_1001791
Disease	Tinnitus	PNPT1 NPBWR1 EFEMP1 PKHD1	7.66e-05	130	51	4	HP_0000360
Disease	glaucoma	PNPT1 EFEMP1 ROR2 PKHD1	1.47e-04	154	51	4	MONDO_0005041
Disease	Parkinson's disease (implicated_via_orthology)	NPBWR1 NPBWR2 SSTR1 SSTR4	1.59e-04	157	51	4	DOID:14330 (implicated_via_orthology)
Disease	Hypoxanthine measurement	GPR61 PKHD1	2.26e-04	13	51	2	EFO_0021604
Disease	Hiatus hernia	PNPT1 EFEMP1	2.63e-04	14	51	2	HP_0002036
Disease	serum IgG glycosylation measurement	PNPT1 CNTNAP5 EFEMP1 GLI3 MDGA2 CYFIP2	2.76e-04	523	51	6	EFO_0005193
Disease	asparaginase hypersensitivity	PNPT1 EFEMP1 PRKCSH	3.25e-04	77	51	3	EFO_0004881
Disease	uterine prolapse	PNPT1 EFEMP1	3.46e-04	16	51	2	EFO_1001864
Disease	diaphragmatic hernia	PNPT1 EFEMP1	6.02e-04	21	51	2	EFO_0008561
Disease	stroke outcome severity measurement	CYSLTR2 MDGA2 TECTA	1.02e-03	114	51	3	EFO_0009603
Disease	Intellectual Disability	PRR12 BPTF PNPT1 ENTPD1 STT3A	1.03e-03	447	51	5	C3714756
Disease	Colorectal Carcinoma	NPBWR2 EFEMP1 GLI3 PKHD1 ATP11C CDC14A	1.29e-03	702	51	6	C0009402
Disease	visceral adipose tissue measurement	BPTF GPR61 ROR2 PKHD1 MDGA2	1.43e-03	481	51	5	EFO_0004765
Disease	Global developmental delay	PRR12 PNPT1 STT3A	1.59e-03	133	51	3	C0557874

Protein segments in the cluster

Peptide	Gene	Start	Entry
PCYQLFSFYNSSGEV	ABRAXAS1	66	Q6UWZ7
YLPFRDASFGNCTYN	CDC14A	126	Q9UNH5
SYIPFRDAAYGSCNF	CDC14B	161	O60729
AYFNNCLNPLFYGFL	AGTR1	291	P30556
NCYNALYAQAPFGGF	ALDH1A3	466	P47895
YFPFDNQQCNLTFGS	CHRNA9	161	Q9UGM1
DNCRYYNPSDSPFYQ	BPTF	3001	Q12830
LSCLNNCLDPFVYYF	P2RY8	281	Q86VZ1
ELNYDFLPNYCYNGS	CYFIP1	846	Q7L576
FLPNYCYNGSTNRFV	CYFIP1	851	Q7L576
GLFYFQDADNFCPTQ	RENBP	301	P51606
FYDNYFDLPGALLCA	NT5DC1	126	Q5TFE4
PLCSNLQNYSGQFYD	GLI3	1431	P10071
YFCFTSNPFFYGCLN	GPR61	331	Q9BZJ8
DFGPNGEFAYLYSQC	PRKCSH	401	P14314
QRGTSCPFYNEYFLF	FER1L4	61	A9Z1Z3
FNFYNGPVSLAYENC	HPS4	116	Q9NQG7
LNFDFLPNYCYNGST	CYFIP2	871	Q96F07
SYCPYSQCAFNGIFL	ENTPD1	336	P49961
SFLQGYNCSVFAYGA	KIF18B	96	Q86Y91
YANSCLNPFLYAFLD	NPBWR2	306	P48146
NPYGPTNTAYCFSFF	MDGA2	826	Q7Z553
LPFCGNNQINYFFCD	OR5V1	166	Q9UGF6
LCPYFFANQEFYSLD	FAM124B	106	Q9H5Z6
GSCPDEYDFSNFYQS	CCDC138	26	Q96M89
CVGPYNASNVASFLY	FFAR1	236	O14842
DCYNYDFLSPNYTGQ	HYAL1	206	Q12794
PQLYCTFNNGLCYEF	ETNK1	196	Q9HBU6
RGFQCLQFYLYNSGS	MEP1B	336	Q16820
NSYYFGGCPDNLTDS	CNTNAP5	486	Q8WYK1
SYANSCLNPFLYAFL	NPBWR1	296	P48145
PSYIGLSFQDFYQQC	ORC2	506	Q13416
YCQCSPGFQLAANNY	EFEMP1	236	Q12805
NPNTNLYFGDFYCMY	PHYHIPL	261	Q96FC7
LGYANSCANPILYGF	SSTR1	311	P30872
FPVGLYYCFSNLSDA	STT3A	371	P46977
YANSCANPILYGFLS	SSTR4	301	P31391
YYSLNQSFVEPFQCP	SHISAL2B	11	A6NKW6
NINYNTDLYNCTFPA	SIAE	281	Q9HAT2
LQYSATFDNFAPGNY	PKHD1	2636	P08F94
FSYGLQPYCGYSNQD	ROR2	686	Q01974
GQRQFCATSNYLGYF	PRR12	1621	Q9ULL5
YLSCFADSNPPAQYS	PSG7	351	Q13046
LFPAGYFYDTQVLCN	PNPT1	141	Q8TCS8
AYIYFTDFCPDNLFN	STXBP3	106	O00186
NFCYQRNQFPPSYAG	SEC23A	86	Q15436
ANACFNPLLYYFAGE	CYSLTR2	296	Q9NS75
FFCGFSQQPLYDAAY	ATP11C	896	Q8NB49
FYNANASDEFCLPNG	TECTA	851	O75443
TCLTYGNSCANPFLY	UTS2R	301	Q9UKP6
QFFSSNLPKYYDNCP	TPTE2	461	Q6XPS3
SSCNCFYNNDYYEPG	ZAN	1091	Q9Y493