Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	chromocenter	CBX5 CBX1 CBX3	3.92e-05	18	78	3	GO:0010369
GeneOntologyCellularComponent	pericentric heterochromatin	CBX5 CBX1 CBX3	2.29e-04	32	78	3	GO:0005721
Domain	ChSh	CBX5 CBX1 CBX3	6.74e-08	3	77	3	SM00300
Domain	Chromo_shadow_dom	CBX5 CBX1 CBX3	6.74e-08	3	77	3	IPR008251
Domain	Chromo_shadow	CBX5 CBX1 CBX3	6.74e-08	3	77	3	PF01393
Domain	Chromo_dom_subgr	CBX5 CBX1 CBX3	7.92e-06	10	77	3	IPR017984
Domain	Chromodomain_CS	CBX5 CBX1 CBX3	5.26e-05	18	77	3	IPR023779
Domain	Chromo_domain	CBX5 CBX1 CBX3	1.28e-04	24	77	3	IPR023780
Domain	Chromo	CBX5 CBX1 CBX3	1.64e-04	26	77	3	PF00385
Domain	Acyl-CoA-binding_prot_CS	ACBD5 ACBD3	1.66e-04	5	77	2	IPR022408
Domain	CHROMO_1	CBX5 CBX1 CBX3	2.05e-04	28	77	3	PS00598
Domain	CHROMO_2	CBX5 CBX1 CBX3	2.05e-04	28	77	3	PS50013
Domain	Chromodomain-like	CBX5 CBX1 CBX3	3.07e-04	32	77	3	IPR016197
Domain	Chromo/shadow_dom	CBX5 CBX1 CBX3	3.36e-04	33	77	3	IPR000953
Domain	CHROMO	CBX5 CBX1 CBX3	3.36e-04	33	77	3	SM00298
Domain	ACB_1	ACBD5 ACBD3	3.48e-04	7	77	2	PS00880
Domain	APC_su10/DOC_dom	MYCBP2 HERC2	3.48e-04	7	77	2	IPR004939
Domain	ACBP	ACBD5 ACBD3	3.48e-04	7	77	2	PF00887
Domain	DOC	MYCBP2 HERC2	3.48e-04	7	77	2	PS51284
Domain	ACB_2	ACBD5 ACBD3	3.48e-04	7	77	2	PS51228
Domain	APC10	MYCBP2 HERC2	3.48e-04	7	77	2	SM01337
Domain	ANAPC10	MYCBP2 HERC2	3.48e-04	7	77	2	PF03256
Domain	Acyl-CoA-binding_protein	ACBD5 ACBD3	4.62e-04	8	77	2	IPR000582
Domain	Patatin/PLipase_A2-rel	PNPLA8 PNPLA7	5.93e-04	9	77	2	IPR002641
Domain	Patatin	PNPLA8 PNPLA7	5.93e-04	9	77	2	PF01734
Domain	PNPLA	PNPLA8 PNPLA7	5.93e-04	9	77	2	PS51635
Domain	Orgcat_transp/SVOP	SVOP SLC22A7	5.93e-04	9	77	2	IPR004749
Domain	WD40_repeat	KATNB1 ELP2 HERC2 DCAF4 DCAF4L1 SHKBP1	9.01e-04	272	77	6	IPR001680
Domain	WD_REPEATS_1	KATNB1 ELP2 HERC2 DCAF4 DCAF4L1 SHKBP1	1.01e-03	278	77	6	PS00678
Domain	WD_REPEATS_2	KATNB1 ELP2 HERC2 DCAF4 DCAF4L1 SHKBP1	1.03e-03	279	77	6	PS50082
Domain	WD_REPEATS_REGION	KATNB1 ELP2 HERC2 DCAF4 DCAF4L1 SHKBP1	1.03e-03	279	77	6	PS50294
Domain	WD40_repeat_dom	ARHGEF10 KATNB1 ELP2 DCAF4 DCAF4L1 SHKBP1	1.42e-03	297	77	6	IPR017986
Domain	Acyl_Trfase/lysoPLipase	PNPLA8 PNPLA7	2.19e-03	17	77	2	IPR016035
Domain	PI-PLC-X	PLCXD3 PLCG1	2.46e-03	18	77	2	PF00388
Domain	PLCXc	PLCXD3 PLCG1	2.46e-03	18	77	2	SM00148
Domain	-	ARHGEF10 KATNB1 ELP2 DCAF4 DCAF4L1 SHKBP1	2.52e-03	333	77	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	ARHGEF10 KATNB1 ELP2 DCAF4 DCAF4L1 SHKBP1	2.59e-03	335	77	6	IPR015943
Domain	PIPLC_X_DOMAIN	PLCXD3 PLCG1	2.74e-03	19	77	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCXD3 PLCG1	2.74e-03	19	77	2	IPR000909
Domain	RCC1	MYCBP2 HERC2	3.04e-03	20	77	2	PF00415
Domain	RCC1_1	MYCBP2 HERC2	3.35e-03	21	77	2	PS00625
Domain	RCC1_2	MYCBP2 HERC2	3.35e-03	21	77	2	PS00626
Domain	RCC1_3	MYCBP2 HERC2	3.35e-03	21	77	2	PS50012
Domain	MHC_I	ULBP2 RAET1L	3.35e-03	21	77	2	PF00129
Domain	MHC_I_a_a1/a2	ULBP2 RAET1L	3.35e-03	21	77	2	IPR001039
Domain	Reg_chr_condens	MYCBP2 HERC2	3.67e-03	22	77	2	IPR000408
Domain	-	MYCBP2 HERC2	3.67e-03	22	77	2	2.130.10.30
Domain	RCC1/BLIP-II	MYCBP2 HERC2	4.01e-03	23	77	2	IPR009091
Pubmed	Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases.	CBX5 CBX1 CBX3 SIN3A	3.88e-10	6	80	4	22318730
Pubmed	Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation.	CBX5 CBX1 CBX3 SIN3A	9.03e-10	7	80	4	22615490
Pubmed	Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells.	CBX5 CBX1 CBX3	1.17e-08	3	80	3	10460410
Pubmed	Stage-specific expression of polycomb group genes in human bone marrow cells.	CBX5 CBX1 CBX3	1.17e-08	3	80	3	9454751
Pubmed	HP1gamma function is required for male germ cell survival and spermatogenesis.	CBX5 CBX1 CBX3	1.17e-08	3	80	3	20423503
Pubmed	Differential contribution of HP1 proteins to DNA end resection and homology-directed repair.	CBX5 CBX1 CBX3	1.17e-08	3	80	3	23287531
Pubmed	Pericentromeric heterochromatin domains are maintained without accumulation of HP1.	CBX5 CBX1 CBX3	1.17e-08	3	80	3	17314413
Pubmed	Dynamic associations of heterochromatin protein 1 with the nuclear envelope.	CBX5 CBX1 CBX3	1.17e-08	3	80	3	11101528
Pubmed	HP1 proteins compact DNA into mechanically and positionally stable phase separated domains.	CBX5 CBX1 CBX3	1.17e-08	3	80	3	33661100
Pubmed	N-terminal phosphorylation of HP1{alpha} promotes its chromatin binding.	CBX5 CBX1 CBX3	1.17e-08	3	80	3	21245376
Pubmed	Maintenance of stable heterochromatin domains by dynamic HP1 binding.	CBX5 CBX1 CBX3	1.17e-08	3	80	3	12560555
Pubmed	Gene regulation by human orthologs of Drosophila heterochromatin protein 1.	CBX5 CBX1 CBX3	1.17e-08	3	80	3	12054505
Pubmed	Plasticity of HP1 proteins in mammalian cells.	CBX5 CBX1 CBX3	1.17e-08	3	80	3	17855382
Pubmed	Dynamic and selective interactions of the transcriptional corepressor TIF1 beta with the heterochromatin protein HP1 isotypes during cell differentiation.	CBX5 CBX1 CBX3	4.68e-08	4	80	3	17381543
Pubmed	Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation.	CBX5 CBX1 CBX3	4.68e-08	4	80	3	15342492
Pubmed	KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.	CBX5 CBX1 CBX3	4.68e-08	4	80	3	10330177
Pubmed	Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment.	CBX5 CBX1 CBX3	4.68e-08	4	80	3	9636146
Pubmed	E3 ubiquitin ligase HECW2 mediates the proteasomal degradation of HP1 isoforms.	CBX5 CBX1 CBX3	4.68e-08	4	80	3	30208514
Pubmed	Heterochromatin protein 1γ deficiency decreases histone H3K27 methylation in mouse neurosphere neuronal genes.	CBX5 CBX1 CBX3	4.68e-08	4	80	3	31961023
Pubmed	The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure.	CBX5 CBX1 CBX3	4.68e-08	4	80	3	11793364
Pubmed	The mouse HP1 proteins are essential for preventing liver tumorigenesis.	CBX5 CBX1 CBX3	4.68e-08	4	80	3	32020053
Pubmed	The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer.	CBX5 CBX1 CBX3	4.68e-08	4	80	3	10747027
Pubmed	Isoform-specific interaction of HP1 with human TAFII130.	CBX5 CBX1 CBX3	1.17e-07	5	80	3	11959914
Pubmed	Ubiquitin ligase RNF123 mediates degradation of heterochromatin protein 1α and β in lamin A/C knock-down cells.	CBX5 CBX1 CBX3	1.17e-07	5	80	3	23077635
Pubmed	Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family.	CBX5 CBX1 CBX3	1.17e-07	5	80	3	10562550
Pubmed	Automethylation of G9a and its implication in wider substrate specificity and HP1 binding.	CBX5 CBX1 CBX3	1.17e-07	5	80	3	17962312
Pubmed	HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding.	CBX5 CBX1 CBX3	1.17e-07	5	80	3	16127177
Pubmed	An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions.	CBX5 CBX1 CBX3	1.17e-07	5	80	3	28059589
Pubmed	Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway.	CBX5 CBX1 CBX3	1.17e-07	5	80	3	23542155
Pubmed	DNA methyltransferase 3b preferentially associates with condensed chromatin.	CBX5 CBX1 CBX3	2.33e-07	6	80	3	20923784
Pubmed	Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes.	CBX5 CBX1 CBX3	2.33e-07	6	80	3	15200951
Pubmed	A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.	CBX5 CBX1 CBX3	2.33e-07	6	80	3	15145825
Pubmed	Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage.	CBX5 CBX1 CBX3	2.33e-07	6	80	3	25634209
Pubmed	A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1.	CBX5 CBX1 CBX3	4.07e-07	7	80	3	12414990
Pubmed	Recognition and specificity determinants of the human cbx chromodomains.	CBX5 CBX1 CBX3	6.51e-07	8	80	3	21047797
Pubmed	Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins.	CBX5 CBX1 CBX3	6.51e-07	8	80	3	11336697
Pubmed	Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation.	CBX5 CBX1 CBX3	6.51e-07	8	80	3	12242305
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SMG1 CLIP2 MYCBP2 ARHGEF10 SYNE2 CDC5L UNC80	9.19e-07	225	80	7	12168954
Pubmed	DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system.	CBX5 CBX1 CBX3	9.75e-07	9	80	3	15120635
Pubmed	Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina.	CBX5 CBX1 CBX3	9.75e-07	9	80	3	23645681
Pubmed	Cdc42 and mDia3 regulate microtubule attachment to kinetochores.	CBX5 CBX1 CBX3	1.39e-06	10	80	3	15085137
Pubmed	Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency.	CBX5 CBX1 CBX3	1.91e-06	11	80	3	23748610
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	SMG1 SACS SYNE2 TAGLN3 KATNB1 CBX3 PNPLA8 PLCG1 GNAO1	2.22e-06	498	80	9	36634849
Pubmed	The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours.	CBX5 CBX1 CBX3	2.54e-06	12	80	3	19486527
Pubmed	Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice.	CBX5 CBX1 CBX3	3.30e-06	13	80	3	21778144
Pubmed	TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids.	CBX5 CBX1 CBX3	3.30e-06	13	80	3	15322135
Pubmed	A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.	CBX5 CBX1 CBX3	3.30e-06	13	80	3	8978696
Pubmed	Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes.	CBX5 CBX1 CBX3	4.19e-06	14	80	3	20231385
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SMG1 RINT1 CLCN5 SACS CBX5 SYNE2 CBX3 GNAO1 MAPK6 PFKM SPAG17 CDC27 TUBD1 ABCB4	4.84e-06	1442	80	14	35575683
Pubmed	Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk.	RINT1 APC	5.23e-06	2	80	2	28264000
Pubmed	Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression.	RIPK2 APC	5.23e-06	2	80	2	31903123
Pubmed	Constitutive heterochromatin during mouse oogenesis: the pattern of histone H3 modifications and localization of HP1alpha and HP1beta proteins.	CBX5 CBX1	5.23e-06	2	80	2	17891782
Pubmed	Heterochromatin protein 1 expression is reduced in human thyroid malignancy.	CBX5 CBX1	5.23e-06	2	80	2	24840329
Pubmed	Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.	CBX5 CBX1	5.23e-06	2	80	2	11242054
Pubmed	A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants.	CBX1 CBX3	5.23e-06	2	80	2	1708124
Pubmed	Heterochromatin protein 1 binds to nucleosomes and DNA in vitro.	CBX5 CBX1	5.23e-06	2	80	2	10882726
Pubmed	Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin.	CBX5 CBX1	5.23e-06	2	80	2	14765118
Pubmed	Regulation of an inducible promoter by an HP1beta-HP1gamma switch.	CBX1 CBX3	5.23e-06	2	80	2	18239689
Pubmed	Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome.	APC NLRP3	5.23e-06	2	80	2	34003774
Pubmed	SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription.	CBX5 CBX3	5.23e-06	2	80	2	23797873
Pubmed	Functional domain analysis of human HP1 isoforms in Drosophila.	CBX1 CBX3	5.23e-06	2	80	2	17575412
Pubmed	Regulated Expression of Chromobox Homolog 5 Revealed in Tumors of Apc(Min) (/+) ROSA11 Gene Trap Mice.	CBX5 APC	5.23e-06	2	80	2	22670227
Pubmed	Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours.	CBX5 CBX3	5.23e-06	2	80	2	20695923
Pubmed	Structural dynamics of the chromo-shadow domain and chromodomain of HP1 bound to histone H3K9 methylated peptide, as measured by site-directed spin-labeling EPR spectroscopy.	CBX5 CBX3	5.23e-06	2	80	2	34139556
Pubmed	A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin.	CBX5 CBX1	5.23e-06	2	80	2	8287692
Pubmed	TIF1β association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis.	CBX5 CBX1 CBX3	5.23e-06	15	80	3	21163256
Pubmed	Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.	CBX5 CBX1 CBX3	5.23e-06	15	80	3	19661379
Pubmed	Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion.	CBX5 CBX1 CBX3	6.42e-06	16	80	3	20871592
Pubmed	CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing.	CBX5 CBX1 CBX3	6.42e-06	16	80	3	24292684
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	RINT1 MYCBP2 SACS ARHGEF10 CBX5 SYNE2 ACBD5 PNPLA8 ELP2 HERC2 CDC5L PFKM ACBD3 MTPN	6.87e-06	1487	80	14	33957083
Pubmed	Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.	CBX5 CBX1 CBX3 SIN3A AHDC1	1.03e-05	124	80	5	20850016
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF136 SCML2 DCUN1D5 CBX5 CBX1 CBX3 SIN3A HERC2 CDC27	1.11e-05	608	80	9	36089195
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CLIP2 MYCBP2 SYNE2 TAGLN3 RIPK2 APC CBX3 SPATA20 GNAO1 HERC2 CDC5L	1.27e-05	963	80	11	28671696
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	FANCC RINT1 ARID1B APC EIF3K CBX1 CBX3 GNAO1 HERC2 CDC5L CDC27 DCAF4	1.28e-05	1155	80	12	20360068
Pubmed	Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.	CBX5 CBX1 CBX3	1.51e-05	21	80	3	11242053
Pubmed	Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation.	CBX5 CBX1	1.57e-05	3	80	2	14585993
Pubmed	Involvement of ZFPIP/Zfp462 in chromatin integrity and survival of P19 pluripotent cells.	CBX5 CBX3	1.57e-05	3	80	2	20219459
Pubmed	Appearance and heterochromatin localization of HP1α in early mouse embryos depends on cytoplasmic clock and H3S10 phosphorylation.	CBX5 CBX1	1.57e-05	3	80	2	22622086
Pubmed	mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival.	CBX5 SIN3A	1.57e-05	3	80	2	15998811
Pubmed	Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1.	CBX5 CBX3	1.57e-05	3	80	2	8663349
Pubmed	Biliary Phospholipids Sustain Enterocyte Proliferation and Intestinal Tumor Progression via Nuclear Receptor Lrh1 in mice.	APC ABCB4	1.57e-05	3	80	2	27995969
Pubmed	Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins.	CBX5 CBX3	1.57e-05	3	80	2	12485163
Pubmed	Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.	ULBP2 RAET1L	1.57e-05	3	80	2	25212604
Pubmed	An epigenetic silencing pathway controlling T helper 2 cell lineage commitment.	CBX5 CBX3	1.57e-05	3	80	2	22763435
Pubmed	Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR.	CBX5 CBX3	1.57e-05	3	80	2	9169472
Pubmed	In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation.	CBX5 CBX1	1.57e-05	3	80	2	15899859
Pubmed	INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1.	CBX5 CBX3	1.57e-05	3	80	2	9864353
Pubmed	Genetic mapping of Mom5, a novel modifier of Apc(Min)-induced intestinal tumorigenesis.	RINT1 APC	1.57e-05	3	80	2	19574546
Pubmed	Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells.	CBX1 CBX3	1.57e-05	3	80	2	23629965
Pubmed	The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.	CBX5 CBX3 SIN3A CDC5L	1.68e-05	66	80	4	32051553
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	SCML2 MYCBP2 ARHGEF10 APC EIF3K CBX1 CBX3 HERC2 CDC27 DCAF4 SHKBP1	1.89e-05	1005	80	11	19615732
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	ARID1B CBX1 CBX3 SIN3A CDC5L	2.59e-05	150	80	5	28242625
Pubmed	Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.	CBX5 CBX1 CBX3 AHDC1	2.64e-05	74	80	4	29795351
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	CBX5 EIF3K CBX1 CBX3 SIN3A	2.84e-05	153	80	5	26365490
Pubmed	Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms.	ULBP2 RAET1L	3.13e-05	4	80	2	20166740
Pubmed	Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.	RIPK2 APC	3.13e-05	4	80	2	25036629
Pubmed	Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential.	CBX5 CBX1	3.13e-05	4	80	2	10938122
Pubmed	Chromatin components as part of a putative transcriptional repressing complex.	CBX5 CBX3	3.13e-05	4	80	2	9636147
Pubmed	Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: a novel cDNA family encodes cell surface proteins sharing partial homology with MHC class I molecules.	ULBP2 RAET1L	3.13e-05	4	80	2	8882725
Pubmed	Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.	CBX5 CBX1	3.13e-05	4	80	2	20498703
Interaction	KLF11 interactions	CBX5 CBX1 CBX3 SIN3A	1.01e-06	20	79	4	int:KLF11
Interaction	ZNF280D interactions	CBX5 CBX1 CBX3 AHDC1	2.19e-06	24	79	4	int:ZNF280D
Interaction	AHDC1 interactions	MFHAS1 CBX5 CBX1 CBX3 AHDC1	1.06e-05	74	79	5	int:AHDC1
Interaction	ZNF566 interactions	CBX5 CBX3 SPATA20	2.55e-05	15	79	3	int:ZNF566
GeneFamily	Chromobox family	CBX5 CBX1 CBX3	1.24e-06	8	52	3	976
GeneFamily	Patatin like phospholipase domain containing	PNPLA8 PNPLA7	3.60e-04	10	52	2	466
GeneFamily	WD repeat domain containing	KATNB1 ELP2 DCAF4 DCAF4L1 SHKBP1	9.17e-04	262	52	5	362
Disease	level of UL16-binding protein 6 in blood serum	ULBP2 RAET1L	7.26e-06	2	80	2	OBA_2043185
Disease	severe acute respiratory syndrome, COVID-19	CLCN5 ULBP2 UNC13C ELP2 RAET1L TUBD1	1.37e-03	447	80	6	EFO_0000694, MONDO_0100096
Disease	frailty measurement	GNAO1 MAPK6	1.77e-03	23	80	2	EFO_0009885
Disease	alcohol use disorder (implicated_via_orthology)	EPS8L2 ARID1B UNC13C CDC5L	1.98e-03	195	80	4	DOID:1574 (implicated_via_orthology)
Disease	osteoarthritis, hip	HERC2 CDC5L SPAG17	2.03e-03	92	80	3	EFO_1000786

Protein segments in the cluster

Peptide	Gene	Start	Entry
TKMAGLMIAAAWVLS	CHRM4	146	P08173
ELTSGWQDVKSMMLV	C2orf16	16	Q68DN1
MASDMAGKIKLWDLR	DCAF4	386	Q8WV16
RSLLMMEDTLWAASG	ARHGEF10	1071	O15013
SRAMGLMKQLNDLWD	CDC5L	726	Q99459
DSSGELMFLMKWKDS	CBX3	131	Q13185
DSCGDLMFLMKWKDT	CBX5	131	P45973
MLAAMGSLAAALWAV	CYP2J2	1	P51589
ASSMLPTMEAWTLRK	CTSL3P	121	Q5NE16
AWSSLGDMTKEEAMI	ACBD5	101	Q5T8D3
NMGLMDNWKSKLDSL	CLIP2	606	Q9UDT6
AWRVMMSLKSGLLAE	ARID1B	1706	Q8NFD5
GAMIWSIDMDDFTGK	CHI3L2	356	Q15782
LEKLMMDWNEASSAP	AHDC1	1201	Q5TGY3
MLVLAWKLEAESMGF	DCUN1D5	86	Q9BTE7
GAHLAAMMLLADWTK	AFMID	166	Q63HM1
MAIGAAELAMKDSGW	OXSM	121	Q9NWU1
MAGMDSGNLKTARLW	MFHAS1	1	Q9Y4C4
TFMDGKLMLLLWSCT	SLC2A7	66	Q6PXP3
GMLLDSWSRMVKSLN	HERC2	2776	O95714
VKLWDLTAGKMMSEF	KATNB1	171	Q9BVA0
SSKPSLMSNAWKEMD	BMP15	171	O95972
MASDMTGKIKLWDLR	DCAF4L1	286	Q3SXM0
KAIDMWAAGCIFAEM	MAPK6	211	Q16659
KEATWESVSMMLQLG	PFKM	66	P08237
WAALGNMSKEDAMVE	ACBD3	146	Q9H3P7
PKEMSLWESLGESWM	EPS8L2	386	Q9H6S3
AGFMWLDKLGLSARM	HPSE	361	Q9Y251
WAEGMTSLMKAALDL	PNPLA7	986	Q6ZV29
MMADSGKRWADIFSK	PLBD1	331	Q6P4A8
WQDKLFMSLGTIMAI	ABCB4	51	P21439
MAILADKANGIMAAW	GBGT1	281	Q8N5D6
VPLMAAAMTSKWVAD	CLCN5	606	P51795
GGWAEMVAEQLLMSA	FANCC	401	Q00597
TDSSGELMFLMKWKN	CBX1	126	P83916
MLGDLSDSQLKVWMS	EIF3K	161	Q9UBQ5
LIKSWLMSGKTDMEA	MAN1C1	396	Q9NR34
MSWMFLRDLLSGVNK	GJB7	1	Q6PEY0
RLLSASMDKTMILWA	ELP2	306	Q6IA86
GSWMQLEMLLRKLSD	C20orf173	116	Q96LM9
DMKSWSTVLAVMGKA	SLC22A7	426	Q9Y694
LGMAKDDILWDDMLE	SACS	2151	Q9NZJ4
ALMNFSWAMDLDPKG	CDC27	756	P30260
GKTILARKMMLDWAS	NLRP3	231	Q96P20
TWENILKDRMGSALM	PNPLA8	536	Q9NP80
MEKLAAGLAGLRWSM	GAREM2	1	Q75VX8
WRAMKMLQGESAEAF	UTP6	571	Q9NYH9
QSWMDLKGMFLSVAA	SUSD2	541	Q9UGT4
LSVLTGLAWMADAME	SVOP	86	Q8N4V2
KLEDVLDSMWGMLRA	SYNE2	4711	Q8WXH0
MLTLEDKDMKGFSWA	TMEM225B	1	P0DP42
LWEGKDMAAVQRTLM	TAGLN3	116	Q9UI15
LTSLMDIDSLMTKWR	TDO2	311	P48775
MLGSVKMEAHDLAEW	FOXA3	1	P55318
SAELLSAMMRLWGDS	GNAO1	121	P09471
LMTWALEAAVLMKKS	SMG1	731	Q96Q15
GSLAMWDLTTAMDGL	SHKBP1	571	Q8TBC3
MAAETSKWLMGEGLE	SIN3A	1226	Q96ST3
TKLFWLMALADSKTM	MYCBP2	4321	O75592
DFPSDWSDGEMMLKL	SPAG17	326	Q6Q759
WSDGEMMLKLGTDIF	SPAG17	331	Q6Q759
AAWSGSLEVMLMLVK	ANKDD1B	141	A6NHY2
EALWDMGAVSMLKNL	APC	696	P25054
KLADWMATLPESMHS	PLCXD3	11	Q63HM9
LDMIVGKAWNMFASK	TUBD1	406	Q9UJT1
SSNGLLWALAMKMAV	TAS1R3	66	Q7RTX0
DVMWETMRNLASIGK	ZNF136	31	P52737
WELLLSMDEHMAGAA	UNC80	1596	Q8N2C7
QMAMSATTGKAWDLA	RBP3	896	P10745
LNMGKISAEIMWTLF	UNC13C	1621	Q8NB66
MCDKEFMWALKNGDL	MTPN	1	P58546
ALQKMDSMLSSEAAW	RINT1	446	Q6NUQ1
RAKWLMMAEKSGAAV	PLPPR3	516	Q6T4P5
WPMFLLKTLNGSEMA	SCML2	141	Q9UQR0
KIADFGLSKWRMMSL	RIPK2	161	O43353
DSKMLAAWNGLMVSG	SPATA20	501	Q8TB22
NMWIKGLTWLMEDTL	PLCG1	131	P19174
IGWLEDFLMGMDSTL	RAET1L	191	Q5VY80
MAALVWLLAGASMSS	SLC35E4	51	Q6ICL7
SMTLWGLAMKTLQNE	ZBTB49	746	Q6ZSB9
IGWLEDFLMGMDSTL	ULBP2	191	Q9BZM5
MAVMDLSSPWALTKQ	ZNF891	1	A8MT65