Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT2A2 UGT2A3 UGT2A1	3.68e-05	35	37	3	GO:0015020
GeneOntologyMolecularFunction	cysteine-type endopeptidase inhibitor activity	PTTG3P PTTG1 BIRC6	6.87e-05	43	37	3	GO:0004869
GeneOntologyMolecularFunction	cAMP-dependent protein kinase activity	PRKX PRKY	6.97e-05	7	37	2	GO:0004691
GeneOntologyMolecularFunction	cyclic nucleotide-dependent protein kinase activity	PRKX PRKY	1.19e-04	9	37	2	GO:0004690
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	UGT2A2 MGAT2 UGT2A3 UGT2A1	1.80e-04	153	37	4	GO:0008194
GeneOntologyMolecularFunction	glycosyltransferase activity	UGT2A2 MGAT2 SIRT3 UGT2A3 UGT2A1	1.80e-04	288	37	5	GO:0016757
GeneOntologyMolecularFunction	hexosyltransferase activity	UGT2A2 MGAT2 UGT2A3 UGT2A1	6.09e-04	211	37	4	GO:0016758
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme activity	UBE2E1 BIRC6	2.14e-03	37	37	2	GO:0061631
GeneOntologyMolecularFunction	calcium ion binding	SYT9 NID2 DCHS2 CDH19 FAT3 AOC3	2.35e-03	749	37	6	GO:0005509
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme activity	UBE2E1 BIRC6	2.88e-03	43	37	2	GO:0061650
GeneOntologyMolecularFunction	heat shock protein binding	PTTG3P PTTG1 DNAJB3	3.38e-03	163	37	3	GO:0031072
GeneOntologyBiologicalProcess	cellular glucuronidation	UGT2A2 UGT2A3 UGT2A1	6.36e-06	21	36	3	GO:0052695
GeneOntologyBiologicalProcess	glucuronate metabolic process	UGT2A2 UGT2A3 UGT2A1	1.23e-05	26	36	3	GO:0019585
GeneOntologyBiologicalProcess	uronic acid metabolic process	UGT2A2 UGT2A3 UGT2A1	1.23e-05	26	36	3	GO:0006063
MousePheno	increased bleeding time	PTTG3P PTTG1 MGAT2 NBEAL2	4.05e-05	91	30	4	MP:0005606
Domain	UDPGT	UGT2A3 UGT2A1	7.01e-04	21	35	2	PS00375
Domain	UDPGT	UGT2A3 UGT2A1	7.01e-04	21	35	2	PF00201
Domain	UDP_glucos_trans	UGT2A3 UGT2A1	7.01e-04	21	35	2	IPR002213
Domain	Cadherin_CS	DCHS2 CDH19 FAT3	1.10e-03	109	35	3	IPR020894
Domain	Cadherin	DCHS2 CDH19 FAT3	1.23e-03	113	35	3	PF00028
Domain	CADHERIN_1	DCHS2 CDH19 FAT3	1.23e-03	113	35	3	PS00232
Domain	CADHERIN_2	DCHS2 CDH19 FAT3	1.26e-03	114	35	3	PS50268
Domain	-	DCHS2 CDH19 FAT3	1.26e-03	114	35	3	2.60.40.60
Domain	CA	DCHS2 CDH19 FAT3	1.29e-03	115	35	3	SM00112
Domain	Cadherin-like	DCHS2 CDH19 FAT3	1.32e-03	116	35	3	IPR015919
Domain	Cadherin	DCHS2 CDH19 FAT3	1.39e-03	118	35	3	IPR002126
Domain	C2	SYT9 CC2D2A BCR	1.87e-03	131	35	3	PF00168
Domain	C2	SYT9 CC2D2A BCR	2.13e-03	137	35	3	SM00239
Domain	C2	SYT9 CC2D2A BCR	2.36e-03	142	35	3	PS50004
Domain	UQ_con	UBE2E1 BIRC6	2.42e-03	39	35	2	PF00179
Domain	UBIQUITIN_CONJUGAT_1	UBE2E1 BIRC6	2.54e-03	40	35	2	PS00183
Domain	-	SYT9 CC2D2A BCR	2.65e-03	148	35	3	2.60.40.150
Domain	UBIQUITIN_CONJUGAT_2	UBE2E1 BIRC6	2.67e-03	41	35	2	PS50127
Domain	UBQ-conjugat_E2	UBE2E1 BIRC6	2.67e-03	41	35	2	IPR000608
Domain	C2_dom	SYT9 CC2D2A BCR	3.54e-03	164	35	3	IPR000008
Domain	-	UBE2E1 BIRC6	4.11e-03	51	35	2	3.10.110.10
Domain	UBQ-conjugating_enzyme/RWD	UBE2E1 BIRC6	4.43e-03	53	35	2	IPR016135
Domain	RhoGAP	ARHGAP15 BCR	6.01e-03	62	35	2	SM00324
Domain	RhoGAP	ARHGAP15 BCR	6.20e-03	63	35	2	PF00620
Domain	RHOGAP	ARHGAP15 BCR	6.39e-03	64	35	2	PS50238
Domain	RhoGAP_dom	ARHGAP15 BCR	6.39e-03	64	35	2	IPR000198
Domain	-	ARHGAP15 BCR	6.39e-03	64	35	2	1.10.555.10
Domain	-	LRPPRC DNAAF4 P3H1	6.76e-03	207	35	3	1.25.40.10
Pathway	REACTOME_GLUCURONIDATION	UGT2A2 UGT2A3 UGT2A1	2.29e-05	24	33	3	MM14599
Pathway	REACTOME_GLUCURONIDATION	UGT2A2 UGT2A3 UGT2A1	2.60e-05	25	33	3	M17787
Pathway	WP_GLUCURONIDATION	UGT2A2 UGT2A3 UGT2A1	2.60e-05	25	33	3	MM15820
Pathway	WP_GLUCURONIDATION	UGT2A2 UGT2A3 UGT2A1	2.93e-05	26	33	3	M39404
Pathway	REACTOME_ASPIRIN_ADME	UGT2A2 UGT2A3 UGT2A1	1.45e-04	44	33	3	M45014
Pathway	REACTOME_ASPIRIN_ADME	UGT2A2 UGT2A3 UGT2A1	1.55e-04	45	33	3	MM15694
Pathway	REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1	PTTG3P PTTG1 UBE2E1	6.77e-04	74	33	3	MM14678
Pathway	REACTOME_ACTIVATION_OF_APC_C_AND_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS	PTTG3P PTTG1 UBE2E1	7.60e-04	77	33	3	MM14692
Pubmed	Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3.	UGT2A2 UGT2A3 UGT2A1	1.20e-09	3	38	3	19858781
Pubmed	Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice.	PTTG3P PTTG1 NBEAL2	4.81e-09	4	38	3	23861251
Pubmed	The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.	PRKX PRKY	1.16e-06	2	38	2	7633447
Pubmed	Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients.	PTTG3P PTTG1	1.16e-06	2	38	2	33173433
Pubmed	Man to mouse--lessons learned from the distal end of the human X chromosome.	PRKX PRKY	1.16e-06	2	38	2	9414316
Pubmed	Profiles of PrKX expression in developmental mouse embryo and human tissues.	PRKX PRKY	1.16e-06	2	38	2	15879576
Pubmed	The lncRNA PTTG3P promotes the progression of CRPC via upregulating PTTG1.	PTTG3P PTTG1	1.16e-06	2	38	2	33743960
Pubmed	The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma.	PTTG3P PTTG1	1.16e-06	2	38	2	29803224
Pubmed	The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste.	UGT2A2 UGT2A1	1.16e-06	2	38	2	35039640
Pubmed	PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.	PRKX PRKY	1.16e-06	2	38	2	21684272
Pubmed	Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.	PRKX PRKY	1.16e-06	2	38	2	9302280
Pubmed	Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis.	UGT2A2 UGT2A1	1.16e-06	2	38	2	11376859
Pubmed	Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase.	UGT2A2 UGT2A1	1.16e-06	2	38	2	10359671
Pubmed	A novel murine PKA-related protein kinase involved in neuronal differentiation.	PRKX PRKY	1.16e-06	2	38	2	10729225
Pubmed	VAP-1-mediated M2 macrophage infiltration underlies IL-1β- but not VEGF-A-induced lymph- and angiogenesis.	IL1B AOC3	3.48e-06	3	38	2	21435467
Pubmed	Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division.	PTTG3P PTTG1	3.48e-06	3	38	2	11682618
Pubmed	PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines.	PTTG3P PTTG1	3.48e-06	3	38	2	17652795
Pubmed	Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging.	PTTG3P PTTG1	3.48e-06	3	38	2	33173537
Pubmed	Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.	PRKX PRKY	3.48e-06	3	38	2	17980165
Pubmed	PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression.	PTTG3P PTTG1	3.48e-06	3	38	2	37159932
Pubmed	Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.	PTTG3P PTTG1	3.48e-06	3	38	2	24395789
Pubmed	FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.	PRKX PRKY	3.48e-06	3	38	2	9154127
Pubmed	Secretion of IL-1β from imatinib-resistant chronic myeloid leukemia cells contributes to BCR-ABL mutation-independent imatinib resistance.	IL1B BCR	3.48e-06	3	38	2	26831735
Pubmed	The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.	PTTG3P PTTG1	3.48e-06	3	38	2	31073078
Pubmed	A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.	PTTG3P PTTG1	3.48e-06	3	38	2	34262048
Pubmed	Pituitary tumor transforming gene as a novel regulatory factor of liver fibrosis.	PTTG3P PTTG1	3.48e-06	3	38	2	25936962
Pubmed	Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes.	PTTG3P PTTG1	3.48e-06	3	38	2	16322543
Pubmed	PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis.	PTTG3P PTTG1	3.48e-06	3	38	2	36737842
Pubmed	Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells.	PTTG3P PTTG1	3.48e-06	3	38	2	17626243
Pubmed	Pituitary tumor transforming gene: an update.	PTTG3P PTTG1	3.48e-06	3	38	2	15281346
Pubmed	The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation.	UGT2A2 UGT2A1	3.48e-06	3	38	2	23756265
Pubmed	Pituitary senescence: the evolving role of Pttg.	PTTG3P PTTG1	3.48e-06	3	38	2	20153804
Pubmed	Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs.	PTTG3P PTTG1	3.48e-06	3	38	2	18639540
Pubmed	Pituitary tumor transforming gene (PTTG) transforming and transactivation activity.	PTTG3P PTTG1	3.48e-06	3	38	2	10713046
Pubmed	The effect of acute and chronic sprint-interval training on LRP130, SIRT3, and PGC-1α expression in human skeletal muscle.	LRPPRC SIRT3	3.48e-06	3	38	2	27604398
Pubmed	Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes.	PTTG3P PTTG1	3.48e-06	3	38	2	12626748
Pubmed	Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II.	PTTG3P PTTG1	3.48e-06	3	38	2	28516917
Pubmed	Sex-steroid milieu determines diabetes rescue in pttg-null mice.	PTTG3P PTTG1	3.48e-06	3	38	2	16731783
Pubmed	Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells.	PTTG3P PTTG1	3.48e-06	3	38	2	16959877
Pubmed	Characterization of the murine pituitary tumor transforming gene (PTTG) and its promoter.	PTTG3P PTTG1	3.48e-06	3	38	2	10650958
Pubmed	Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells.	PTTG3P PTTG1	3.48e-06	3	38	2	23867215
Pubmed	Characterization of the pituitary tumor transforming gene 1 knockout mouse retina.	PTTG3P PTTG1	3.48e-06	3	38	2	21203837
Pubmed	Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells.	PTTG3P PTTG1	3.48e-06	3	38	2	17065388
Pubmed	Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis.	PTTG3P PTTG1	6.96e-06	4	38	2	15919720
Pubmed	Anaphase B precedes anaphase A in the mouse egg.	PTTG3P PTTG1	6.96e-06	4	38	2	22342753
Pubmed	Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells.	PTTG3P PTTG1	6.96e-06	4	38	2	16030258
Pubmed	Degradation of securin in mouse and pig oocytes is dependent on ubiquitin-proteasome pathway and is required for proteolysis of the cohesion subunit, Rec8, at the metaphase-to-anaphase transition.	PTTG3P PTTG1	6.96e-06	4	38	2	16720305
Pubmed	The pituitary tumor-transforming gene promotes angiogenesis in a mouse model of follicular thyroid cancer.	PTTG3P PTTG1	6.96e-06	4	38	2	17127711
Pubmed	Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.	PTTG3P PTTG1	6.96e-06	4	38	2	20116377
Pubmed	Pituitary tumor transforming gene 1 induces tumor necrosis factor-α production from keratinocytes: implication for involvement in the pathophysiology of psoriasis.	PTTG3P PTTG1	6.96e-06	4	38	2	23677169
Pubmed	SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.	CERS1 SIRT3	6.96e-06	4	38	2	26620563
Pubmed	Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation.	PTTG3P PTTG1	6.96e-06	4	38	2	19124608
Pubmed	Induction of Dlk1 by PTTG1 inhibits adipocyte differentiation and correlates with malignant transformation.	PTTG3P PTTG1	6.96e-06	4	38	2	19477929
Pubmed	The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.	PTTG3P PTTG1	6.96e-06	4	38	2	35050550
Pubmed	Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts.	PTTG3P PTTG1	6.96e-06	4	38	2	11516952
Pubmed	Tumorigenic potential of pituitary tumor transforming gene (PTTG) in vivo investigated using a transgenic mouse model, and effects of cross breeding with p53 (+/-) transgenic mice.	PTTG3P PTTG1	6.96e-06	4	38	2	23164239
Pubmed	Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice.	PTTG3P PTTG1	6.96e-06	4	38	2	30259712
Pubmed	Expression of PTTG and prc1 genes during telencephalic neurogenesis.	PTTG3P PTTG1	6.96e-06	4	38	2	10727870
Pubmed	Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics.	PTTG3P PTTG1	6.96e-06	4	38	2	24927528
Pubmed	The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase.	PTTG3P PTTG1	6.96e-06	4	38	2	16533944
Pubmed	Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.	PTTG3P PTTG1	6.96e-06	4	38	2	16533945
Pubmed	Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.	PTTG3P PTTG1	6.96e-06	4	38	2	17039256
Pubmed	Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells.	PTTG3P PTTG1	6.96e-06	4	38	2	25421944
Pubmed	A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1.	PTTG3P PTTG1	6.96e-06	4	38	2	17234588
Pubmed	Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1.	PTTG3P PTTG1	6.96e-06	4	38	2	14593421
Pubmed	Securin regulates entry into M-phase by modulating the stability of cyclin B.	PTTG3P PTTG1	6.96e-06	4	38	2	18364698
Pubmed	Glypican-1 regulates anaphase promoting complex/cyclosome substrates and cell cycle progression in endothelial cells.	PTTG3P PTTG1	6.96e-06	4	38	2	18417614
Pubmed	p21(Cip1) restrains pituitary tumor growth.	PTTG3P PTTG1	1.16e-05	5	38	2	18981426
Pubmed	MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte.	PTTG3P PTTG1	1.16e-05	5	38	2	39093409
Pubmed	Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.	PTTG3P PTTG1	1.16e-05	5	38	2	21156286
Pubmed	PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.	PTTG3P PTTG1	1.16e-05	5	38	2	22535767
Pubmed	Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition.	PTTG3P PTTG1	1.16e-05	5	38	2	28658604
Pubmed	Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.	UGT2A2 UGT2A1	1.16e-05	5	38	2	16141793
Pubmed	Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth.	PTTG3P PTTG1	1.16e-05	5	38	2	17975001
Pubmed	The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity.	PTTG3P PTTG1	1.16e-05	5	38	2	14561405
Pubmed	The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.	PTTG3P PTTG1	1.16e-05	5	38	2	16355229
Pubmed	Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice.	PTTG3P PTTG1	1.16e-05	5	38	2	21076990
Pubmed	Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells.	PTTG3P PTTG1	1.74e-05	6	38	2	33181265
Pubmed	mTOR promotes pituitary tumor development through activation of PTTG1.	PTTG3P PTTG1	1.74e-05	6	38	2	27524416
Pubmed	Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation.	PTTG3P PTTG1	1.74e-05	6	38	2	21991377
Pubmed	Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos.	PTTG3P PTTG1	2.43e-05	7	38	2	17325031
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	DCHS2 FAT3	2.43e-05	7	38	2	16059920
Pubmed	Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.	PRKX PRKY	3.24e-05	8	38	2	22641646
Pubmed	Identification of disease-relevant modulators of the SHH pathway in the developing brain.	PTTG3P PTTG1	4.16e-05	9	38	2	34463328
Pubmed	Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.	FANCL ARHGAP15	4.16e-05	9	38	2	21297076
Pubmed	Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.	PTTG3P PTTG1	5.20e-05	10	38	2	26731471
Pubmed	Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis.	PTTG3P PTTG1	6.35e-05	11	38	2	21494564
Pubmed	Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure.	PTTG3P PTTG1	9.00e-05	13	38	2	34571959
Pubmed	Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence.	PTTG3P PTTG1	9.00e-05	13	38	2	19213844
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	LRPPRC MGAT2 BCR BIRC6 P3H1 SIRT3	9.29e-05	686	38	6	28380382
Pubmed	TIF1β association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis.	PTTG3P PTTG1	1.21e-04	15	38	2	21163256
Pubmed	Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells.	PTTG3P PTTG1	1.38e-04	16	38	2	18232736
Pubmed	Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.	PTTG1 UBE2E1	1.56e-04	17	38	2	12070128
Pubmed	Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.	DCHS2 FAT3	1.76e-04	18	38	2	33108146
Pubmed	Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions.	PTTG3P PTTG1	2.41e-04	21	38	2	15937080
Pubmed	Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney development.	PTTG3P PTTG1	3.72e-04	26	38	2	37727504
Pubmed	Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye.	PTTG3P PTTG1	4.01e-04	27	38	2	23676271
Pubmed	Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.	LRPPRC BAZ1A P3H1 PRDX1	4.71e-04	333	38	4	36779763
Pubmed	MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.	BIRC6 SIRT3 UGT2A3	4.86e-04	140	38	3	20819778
Pubmed	Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development.	PTTG3P PTTG1	4.96e-04	30	38	2	16420439
Interaction	UGT2A2 interactions	UGT2A2 UGT2A3	2.93e-06	2	35	2	int:UGT2A2
Interaction	UGT2A3 interactions	UGT2A2 UGT2A3	4.38e-05	6	35	2	int:UGT2A3
Interaction	UGT2B15 interactions	UGT2A3 UGT2A1	4.38e-05	6	35	2	int:UGT2B15
Cytoband	Ensembl 112 genes in cytogenetic band chr4q13	UGT2A2 FDCSP UGT2A3 UGT2A1	8.87e-06	157	38	4	chr4q13
Cytoband	4q13	FDCSP UGT2A1	6.96e-05	15	38	2	4q13
Cytoband	1p34.1	P3H1 PRDX1	1.03e-03	57	38	2	1p34.1
GeneFamily	UDP glucuronosyltransferases	UGT2A2 UGT2A3 UGT2A1	1.13e-05	32	25	3	363
GeneFamily	Cadherin related	DCHS2 FAT3	2.46e-04	17	25	2	24
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2E1 BIRC6	1.46e-03	41	25	2	102
GeneFamily	PHD finger proteins	FANCL BAZ1A	6.82e-03	90	25	2	88
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SYT9 CERS1 ZFHX4 UGT2A1	2.34e-06	110	38	4	c80d1c3df75648e2c8f6832279c2acca63d76681
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MGAT2 ARHGAP15 MFHAS1 PRDX1	1.99e-05	189	38	4	284f39dfacec76004daae9dd5317fb7b1f04fa99
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38\|World / Primary Cells by Cluster	ZFHX4 BAZ1A PRKX PRDX1	2.30e-05	196	38	4	38da0751941adca650fe9b383d9f343153978eb5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn\|World / Primary Cells by Cluster	ZFHX4 BAZ1A PRKX PRDX1	2.30e-05	196	38	4	721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell	Non-neuronal-Dividing-IPC-IPC-div2\|World / Primary Cells by Cluster	PTTG1 ZFHX4 BAZ1A PRDX1	2.48e-05	200	38	4	4923d7a4f00853c4d76fc1cc0fa82d522a2302e7
ToppCell	Non-neuronal-Dividing-IPC-IPC-div2-5\|World / Primary Cells by Cluster	PTTG1 ZFHX4 BAZ1A PRDX1	2.48e-05	200	38	4	dc1c1506823eaa105f1532c6b5d4efa14e788314
Disease	Abnormality of the sense of smell, COVID-19 symptoms measurement, ageusia	UGT2A2 UGT2A1	1.45e-06	2	36	2	EFO_0600019, EFO_1001758, HP_0004408
Disease	retinal detachment	CDH19 FAT3	3.03e-05	7	36	2	EFO_0005773
Disease	chronic myeloid leukemia (is_marker_for)	IL1B BCR	4.98e-04	27	36	2	DOID:8552 (is_marker_for)
Disease	type 2 diabetes mellitus (is_marker_for)	IL1B SIRT3 AOC3	6.12e-04	136	36	3	DOID:9352 (is_marker_for)
Disease	malignant epithelial tumor of ovary	UGT2A2 UGT2A1	8.40e-04	35	36	2	MONDO_0018364
Disease	homocysteine measurement	DCHS2 PRDX1	1.45e-03	46	36	2	EFO_0004578
Disease	neuroimaging measurement	CC2D2A DCHS2 ARMC9 BCR BAZ1A FAT3	1.71e-03	1069	36	6	EFO_0004346
Disease	diabetic retinopathy (is_marker_for)	IL1B AOC3	1.99e-03	54	36	2	DOID:8947 (is_marker_for)
Disease	Necrosis	IL1B BCR	2.06e-03	55	36	2	C0027540
Disease	polyp of colon	NID2 SIRT3	2.14e-03	56	36	2	MONDO_0021400
Disease	Psoriasis	PTTG1 IL1B	2.21e-03	57	36	2	C0033860
Disease	Pustulosis of Palms and Soles	PTTG1 IL1B	2.21e-03	57	36	2	C0030246
Disease	obesity (implicated_via_orthology)	DCHS2 ZFHX4 AOC3	2.28e-03	215	36	3	DOID:9970 (implicated_via_orthology)
Disease	microglial activation measurement	ARMC9 FAT3	2.37e-03	59	36	2	EFO_0010940
Disease	smoking status measurement	CC2D2A LRPPRC UBE2E1 ARHGAP15 BIRC6 FAT3	2.58e-03	1160	36	6	EFO_0006527
Disease	Arsenic Induced Polyneuropathy	UBE2E1 IL1B	2.61e-03	62	36	2	C0751852
Disease	Arsenic Encephalopathy	UBE2E1 IL1B	2.61e-03	62	36	2	C0751851
Disease	Arsenic Poisoning	UBE2E1 IL1B	2.61e-03	62	36	2	C0311375
Disease	Arsenic Poisoning, Inorganic	UBE2E1 IL1B	2.61e-03	62	36	2	C0274861

Protein segments in the cluster

Peptide	Gene	Start	Entry
FEFDVYFPQDYPSSP	BIRC6	4626	Q9NR09
PEPLFTDEFYPNFAE	BCR	1136	P11274
VLDNPSPFYNPFQFE	ASF1A	11	Q9Y294
PTFARYVFPCFDEPA	LVRN	241	Q6Q4G3
IAEQDFSYFFPDDPP	BAZ1A	251	Q9NRL2
FSYFFPDDPPTFIFS	BAZ1A	256	Q9NRL2
VGFFLRPYNFFDEDP	AOC3	701	Q16853
LFFAYDVFGIPFVDP	P3H1	376	Q32P28
STFFPFIFEEEPIFF	IL1B	91	P01584
FFPFSIQLYPNEFPG	MGAT2	176	Q10469
QIEYSFPFTFPLGLF	MFHAS1	881	Q9Y4C4
QTTEFLPFYALPFVP	ARMC9	141	Q7Z3E5
FGPLIFFYIFPFPTS	OR4F6	251	Q8NGB9
PFIEPPESFEFYAQQ	LRPPRC	1371	P42704
FFFYPLDFTFVCPTE	PRDX1	41	Q06830
FEPIFTQDQYFFTLP	DCHS2	2876	Q6V1P9
DYDFPTDFPAIAPFL	NID2	96	Q14112
VPPGFPSAEEAYNFF	CC2D2A	181	Q9P2K1
PFEYVFSFRDPADVF	DNAJB3	86	Q8WWF6
SPIPLTFDEPFYNFT	FAT3	1356	Q8TDW7
FGTDYPFFHDPPSVF	CERS1	121	P27544
ELASGFFVFPYPYPF	FDCSP	36	Q8NFU4
PFLFEAFLYAPIDDE	DNAAF4	46	Q8WXU2
EPPLFLLPYYVFEVF	CDH19	366	Q9H159
YPEIEKFFPFNPLDF	PTTG1	111	O95997
LNPVFDEVFLFPVPY	SYT9	281	Q86SS6
ESPDYFVDFPVPFCA	FANCL	161	Q9NW38
IPEFFYFPDFLENQN	NBEAL2	2216	Q6ZNJ1
FPPFFDDNPFGIYQK	PRKY	241	O43930
ELPEPLFPYSFFEQF	ARHGAP15	361	Q53QZ3
YPEIEKLFPFNPLGF	PTTG3P	111	Q9NZH4
YDLPYPEAIFELPFF	SIRT3	171	Q9NTG7
QFLFPFYIPGTEFSL	ZFHX4	1691	Q86UP3
FPPFFDDNPFGIYQK	PRKX	241	P51817
DFEFPQPYQPNFEFV	UGT2A3	261	Q6UWM9
FFLDITFTPEYPFKP	UBE2E1	96	P51965
FEFPRPYLPNFEFVG	UGT2A1	306	P0DTE4
FEFPRPYLPNFEFVG	UGT2A2	271	P0DTE5
VFSVYLPDFLPPFQQ	TMEM272	126	A0A1B0GTI8