Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	AEN POLQ REXO1	8.46e-05	47	34	3	3.30.420.10
Domain	RNaseH-like_dom	AEN POLQ REXO1	2.66e-04	69	34	3	IPR012337
Domain	EXOIII	AEN REXO1	2.89e-04	14	34	2	SM00479
Domain	Exonuclease_RNaseT/DNA_pol3	AEN REXO1	2.89e-04	14	34	2	IPR013520
Domain	RNase_T	AEN REXO1	2.89e-04	14	34	2	PF00929
Domain	LIM	MICALL1 LIMD1	6.99e-03	69	34	2	PF00412
Domain	-	MICALL1 LIMD1	7.19e-03	70	34	2	2.10.110.10
Domain	LIM_DOMAIN_2	MICALL1 LIMD1	7.39e-03	71	34	2	PS50023
Domain	Znf_LIM	MICALL1 LIMD1	7.39e-03	71	34	2	IPR001781
Domain	LIM_DOMAIN_1	MICALL1 LIMD1	7.39e-03	71	34	2	PS00478
Domain	LIM	MICALL1 LIMD1	7.39e-03	71	34	2	SM00132
Domain	Collagen	C1QTNF2 COL25A1	1.04e-02	85	34	2	PF01391
Domain	Collagen	C1QTNF2 COL25A1	1.04e-02	85	34	2	IPR008160
Domain	Homeobox_metazoa	HOXD11 NKX2-1	1.17e-02	90	34	2	IPR020479
Pubmed	QTL Mapping of Endocochlear Potential Differences between C57BL/6J and BALB/cJ mice.	AKAP6 NKX2-1	1.04e-05	5	36	2	26980469
Pubmed	Inositol 1,4,5-trisphosphate receptor 2 as a novel marker of vasculature to delineate processes of cardiopulmonary development.	NKX2-1 TBX1	1.56e-05	6	36	2	31758944
Pubmed	The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning.	NKX2-1 TBX1	2.18e-05	7	36	2	17164259
Pubmed	Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.	NKX2-1 TBX1	2.18e-05	7	36	2	34643182
Pubmed	Early thyroid development requires a Tbx1-Fgf8 pathway.	NKX2-1 TBX1	8.07e-05	13	36	2	19389367
Pubmed	Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA.	RORC TBX1	9.41e-05	14	36	2	27022145
Pubmed	Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice.	NKX2-1 TBX1	1.08e-04	15	36	2	21177346
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	NKX2-1 TBX1	1.96e-04	20	36	2	12812790
Pubmed	Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.	COL25A1 NOTCH4	2.16e-04	21	36	2	21408207
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	AKAP6 RRAS NKX2-1 TULP1	3.65e-04	329	36	4	17474147
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SAMD1 MSL1 BRD3 NKX2-1 RAI1	3.87e-04	608	36	5	36089195
Pubmed	Dosage-dependent requirement for mouse Vezf1 in vascular system development.	TBX1 NOTCH4	4.16e-04	29	36	2	15882861
Pubmed	Common genetic variation and the control of HIV-1 in humans.	CDSN NOTCH4	7.93e-04	40	36	2	20041166
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	MICALL1 USP31 TSPYL5 NECTIN3 HNRNPUL2	8.26e-04	719	36	5	35337019
Pubmed	Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.	NKX2-1 TBX1	8.33e-04	41	36	2	25452572
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	NKX2-1 NOTCH4	8.33e-04	41	36	2	22675208
Pubmed	WNT/RYK signaling restricts goblet cell differentiation during lung development and repair.	NKX2-1 TBX1	8.74e-04	42	36	2	31776260
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	MSL1 C1QTNF2 NKX2-1 RAI1	1.00e-03	431	36	4	33660365
Cytoband	3q13.33	GPR156 POLQ	2.56e-04	30	36	2	3q13.33
Cytoband	Ensembl 112 genes in cytogenetic band chr3q13	GPR156 NECTIN3 POLQ	6.99e-04	221	36	3	chr3q13
Cytoband	6p21.3	CDSN TULP1 NOTCH4	9.97e-04	250	36	3	6p21.3
Cytoband	1q21	CRCT1 RORC	2.34e-03	91	36	2	1q21
GeneFamily	Exonucleases	AEN REXO1	1.53e-04	16	21	2	544
GeneFamily	LIM domain containing	MICALL1 LIMD1	2.11e-03	59	21	2	1218
Disease	susceptibility to plantar warts measurement	CRCT1 NKX2-1 NOTCH4	1.40e-04	90	33	3	EFO_0008406
Disease	asthma	DZANK1 CRCT1 RORC CDSN NOTCH4	1.39e-03	751	33	5	MONDO_0004979
Disease	atopic asthma	RORC MSL1 NOTCH4	1.42e-03	199	33	3	EFO_0010638
Disease	age at diagnosis, type 1 diabetes mellitus	USP31 NOTCH4	2.20e-03	62	33	2	EFO_0004918, MONDO_0005147
Disease	psoriasis	CRCT1 CDSN NOTCH4	3.48e-03	273	33	3	EFO_0000676
Disease	Inguinal hernia	CDSN TULP1 NOTCH4	4.00e-03	287	33	3	HP_0000023

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPAPGKASGPLPSKC	AEN	96	Q8WTP8
ARKEKPGSAPSGGPS	BRD3	686	Q15059
KGFSKGSSQGPAPCP	CRCT1	11	Q9UGL9
AGAKPCGSSSAGKIP	CDSN	481	Q15517
DGKPCQAGAPAPGAA	NKX2-1	266	P43699
KGPECAAAATAGKPP	RAI1	1741	Q7Z5J4
GAKDKPPPGAGARAA	MTCL1	106	Q9Y4B5
KPGCTDLGTGPKLSP	LIMD1	371	Q9UGP4
KKGEPGLPGPCSCGS	C1QTNF2	131	Q9BXJ5
SECNCPAGPPGKRGK	COL25A1	116	Q9BXS0
AKGGKARPPTAPGTS	FAM217B	201	Q9NTX9
AGPGGACKAEPRPVA	HNRNPUL2	51	Q1KMD3
RGSSGPQPAKPCSGA	MICALL1	586	Q8N3F8
GEPAAAGAGCSPRPK	MSL1	116	Q68DK7
KPGSGAPARASCPGK	DPYSL4	511	O14531
PPPGLGRCLKAAAAG	POLQ	41	O75417
GGSPCTKATPGSEPK	HOXD11	221	P31277
GSGRAPSPAAPCLSK	GPR156	701	Q8NFN8
CSGDKAPPPPTQKGG	DZANK1	321	Q9NVP4
KASSAPGPGRATKGP	C4orf54	761	D6RIA3
ADGTPFGCPPGRKEK	SAMD1	441	Q6SPF0
TGAPPAPSCKDGAQG	REXO1	381	Q8N1G1
PGPRCQKPGAKGCEG	NOTCH4	1166	Q99466
PPCRTPKRGTGSGKQ	AKAP6	506	Q13023
SPCPTGSKPRKPGAG	TULP1	51	O00294
ACPPGLLKASGSGPS	RORC	171	P51449
QKSDPRLPCKGGGPD	MSMP	106	Q1L6U9
CRATKGQAGDGPKPA	TMEM247	76	A6NEH6
PEGPGASCAAAAKAP	TBX1	86	O43435
APGSGPPAAASGKEK	USP31	6	Q70CQ4
SPPSAPRKKGGGCPC	RRAS	201	P10301
CSPGGALASPEPGRK	PSPHP1	6	O15172
KSSLKFSPGPCPGPG	UBXN11	476	Q5T124
GKKAPETCSTAGRGP	TSPYL5	146	Q86VY4
KLPCTPPGAGQGRFS	MXRA5	2656	Q9NR99
RPSPLCPGGGKAQLS	NECTIN3	6	Q9NQS3