Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear glucocorticoid receptor binding	IPO13 FKBP4 SMAD3	4.32e-05	20	69	3	GO:0035259
GeneOntologyMolecularFunction	glucokinase activity	HK1 HK2	1.17e-04	5	69	2	GO:0004340
GeneOntologyMolecularFunction	hexokinase activity	HK1 HK2	1.17e-04	5	69	2	GO:0004396
GeneOntologyMolecularFunction	fructokinase activity	HK1 HK2	1.17e-04	5	69	2	GO:0008865
GeneOntologyMolecularFunction	nuclear receptor binding	MED14 IPO13 TADA3 FKBP4 SMAD3	4.72e-04	187	69	5	GO:0016922
GeneOntologyMolecularFunction	D-glucose binding	HK1 HK2	1.04e-03	14	69	2	GO:0005536
GeneOntologyMolecularFunction	titin binding	CAPN3 MYBPC3	1.04e-03	14	69	2	GO:0031432
GeneOntologyMolecularFunction	snRNP binding	SNRPB SNRPN	1.37e-03	16	69	2	GO:0070990
GeneOntologyMolecularFunction	calcium-dependent cysteine-type endopeptidase activity	CAPN3 CAPN11	1.55e-03	17	69	2	GO:0004198
GeneOntologyMolecularFunction	I-SMAD binding	ACVR1B SMAD3	1.55e-03	17	69	2	GO:0070411
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	USP26 ATXN3L	2.37e-03	21	69	2	GO:1990380
GeneOntologyMolecularFunction	carbohydrate kinase activity	HK1 HK2	2.37e-03	21	69	2	GO:0019200
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE6A PDE6C	2.60e-03	22	69	2	GO:0004115
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	FCSK IGF1R HK1 HK2 MAP3K9 ACVR1B NLK MAP3K19	3.01e-03	709	69	8	GO:0016773
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE6A PDE6C	3.09e-03	24	69	2	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE6A PDE6C	3.35e-03	25	69	2	GO:0004114
GeneOntologyMolecularFunction	syntaxin binding	VPS11 BLOC1S6 NAPA	3.40e-03	87	69	3	GO:0019905
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	MED14 IPO13 TADA3 FKBP4 NLK SMAD3 DHRS7B	3.90e-03	582	69	7	GO:0140297
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE6A PDE6C	3.91e-03	27	69	2	GO:0004112
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	MAP3K9 MAP3K19	3.91e-03	27	69	2	GO:0004709
GeneOntologyMolecularFunction	guanyl ribonucleotide binding	CPLANE2 IFT27 RAB33A PDE6C RAB14 FKBP4	4.07e-03	439	69	6	GO:0032561
GeneOntologyMolecularFunction	guanyl nucleotide binding	CPLANE2 IFT27 RAB33A PDE6C RAB14 FKBP4	4.07e-03	439	69	6	GO:0019001
GeneOntologyMolecularFunction	transcription factor binding	ATXN3L MED14 IPO13 TADA3 FKBP4 NLK SMAD3 DHRS7B	4.33e-03	753	69	8	GO:0008134
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP26 ATXN3L CAPN3 CAPN11	4.40e-03	192	69	4	GO:0008234
GeneOntologyMolecularFunction	kinase activity	FCSK IGF1R HK1 HK2 MAP3K9 ACVR1B NLK MAP3K19	4.72e-03	764	69	8	GO:0016301
GeneOntologyMolecularFunction	ubiquitin protein ligase binding	ATXN3L ACVR1B BECN1 NLK SMAD3	6.18e-03	337	69	5	GO:0031625
GeneOntologyBiologicalProcess	intracellular transport	NRDE2 IFT27 VPS11 BLOC1S6 DST COPG1 IPO13 NAPA COPG2 DENND5A RAB14 BECN1 NUP160 SMAD3 EPG5 MYBPC3 AP3S2	7.62e-06	1496	70	17	GO:0046907
GeneOntologyBiologicalProcess	transport along microtubule	IFT27 BLOC1S6 DST COPG1 COPG2 AP3S2	5.55e-05	197	70	6	GO:0010970
GeneOntologyBiologicalProcess	carbohydrate phosphorylation	FCSK HK1 HK2	8.16e-05	25	70	3	GO:0046835
GeneOntologyBiologicalProcess	maintenance of protein location in mitochondrion	HK1 HK2	1.13e-04	5	70	2	GO:0072656
GeneOntologyBiologicalProcess	cytoskeleton-dependent intracellular transport	IFT27 BLOC1S6 DST COPG1 COPG2 AP3S2	1.15e-04	225	70	6	GO:0030705
GeneOntologyCellularComponent	membrane coat	VPS11 COPG1 COPG2 AP3S2	4.19e-04	106	69	4	GO:0030117
GeneOntologyCellularComponent	coated membrane	VPS11 COPG1 COPG2 AP3S2	4.19e-04	106	69	4	GO:0048475
GeneOntologyCellularComponent	AP-3 adaptor complex	VPS11 AP3S2	8.18e-04	13	69	2	GO:0030123
GeneOntologyCellularComponent	COPI vesicle coat	COPG1 COPG2	8.18e-04	13	69	2	GO:0030126
GeneOntologyCellularComponent	U4 snRNP	SNRPB SNRPN	8.18e-04	13	69	2	GO:0005687
Domain	Coatomer_g_Cpla	COPG1 COPG2	1.38e-05	2	70	2	IPR032154
Domain	-	COPG1 COPG2	1.38e-05	2	70	2	2.60.40.1480
Domain	snRNP-assoc_SmB/SmN	SNRPB SNRPN	1.38e-05	2	70	2	IPR017131
Domain	Coatomer_gsu	COPG1 COPG2	1.38e-05	2	70	2	IPR017106
Domain	COP-gamma_platf	COPG1 COPG2	1.38e-05	2	70	2	PF08752
Domain	Coatomer_g_Cpla	COPG1 COPG2	1.38e-05	2	70	2	PF16381
Domain	Coatomer_gsu_app_Ig-like-sub	COPG1 COPG2	1.38e-05	2	70	2	IPR013040
Domain	-	COPG1 COPG2	8.27e-05	4	70	2	3.30.310.30
Domain	Clathrin_a/coatomer_app_sub_C	COPG1 COPG2	8.27e-05	4	70	2	IPR015873
Domain	Hexokinase_C	HK1 HK2	1.37e-04	5	70	2	IPR022673
Domain	Hexokinase_N	HK1 HK2	1.37e-04	5	70	2	IPR022672
Domain	Hexokinase_1	HK1 HK2	1.37e-04	5	70	2	PF00349
Domain	Hexokinase_2	HK1 HK2	1.37e-04	5	70	2	PF03727
Domain	HEXOKINASE_2	HK1 HK2	1.37e-04	5	70	2	PS51748
Domain	Hexokinase_BS	HK1 HK2	1.37e-04	5	70	2	IPR019807
Domain	HEXOKINASE_1	HK1 HK2	1.37e-04	5	70	2	PS00378
Domain	HEAT_REPEAT	COPG1 IPO13 COPG2 EIF4G3	1.38e-04	70	70	4	PS50077
Domain	Hexokinase	HK1 HK2	2.06e-04	6	70	2	IPR001312
Domain	GAF	PDE6A PDE6C	2.87e-04	7	70	2	PF01590
Domain	Coatomer/calthrin_app_sub_C	COPG1 COPG2	3.82e-04	8	70	2	IPR009028
Domain	GAF	PDE6A PDE6C	3.82e-04	8	70	2	IPR003018
Domain	GAF	PDE6A PDE6C	3.82e-04	8	70	2	SM00065
Domain	GAF_dom-like	PDE6A PDE6C	4.90e-04	9	70	2	IPR029016
Domain	-	PDE6A PDE6C	4.90e-04	9	70	2	3.30.450.40
Domain	Elongated_TPR_rpt_dom	UNC45A FKBP4	7.45e-04	11	70	2	IPR023114
Domain	Calpain_III	CAPN3 CAPN11	8.92e-04	12	70	2	IPR022683
Domain	calpain_III	CAPN3 CAPN11	8.92e-04	12	70	2	SM00720
Domain	C2_III	CAPN3 CAPN11	8.92e-04	12	70	2	IPR033883
Domain	Coatomer/clathrin_app_Ig-like	COPG1 COPG2	8.92e-04	12	70	2	IPR013041
Domain	Calpain_domain_III	CAPN3 CAPN11	1.05e-03	13	70	2	IPR022682
Domain	Calpain_III	CAPN3 CAPN11	1.05e-03	13	70	2	PF01067
Domain	-	NRDE2 VPS11 NAPA UNC45A FKBP4	1.08e-03	207	70	5	1.25.40.10
Domain	Calpain_cysteine_protease	CAPN3 CAPN11	1.22e-03	14	70	2	IPR022684
Domain	Clathrin/coatomer_adapt-like_N	COPG1 COPG2	1.41e-03	15	70	2	IPR002553
Domain	Adaptin_N	COPG1 COPG2	1.41e-03	15	70	2	PF01602
Domain	CysPc	CAPN3 CAPN11	1.41e-03	15	70	2	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN3 CAPN11	1.41e-03	15	70	2	IPR001300
Domain	Peptidase_C2	CAPN3 CAPN11	1.41e-03	15	70	2	PF00648
Domain	CALPAIN_CAT	CAPN3 CAPN11	1.41e-03	15	70	2	PS50203
Domain	ARM-type_fold	VPS11 COPG1 IPO13 COPG2 UNC45A EIF4G3	1.69e-03	339	70	6	IPR016024
Domain	Ras	CPLANE2 IFT27 RAB33A RAB14	1.70e-03	136	70	4	PF00071
Domain	TPR-like_helical_dom	NRDE2 VPS11 NAPA UNC45A FKBP4	1.81e-03	233	70	5	IPR011990
Domain	Sm	SNRPB SNRPN	2.27e-03	19	70	2	SM00651
Domain	LSM	SNRPB SNRPN	2.27e-03	19	70	2	PF01423
Domain	PDEase	PDE6A PDE6C	2.27e-03	19	70	2	IPR023088
Domain	LSM_dom_euk/arc	SNRPB SNRPN	2.27e-03	19	70	2	IPR001163
Domain	RAB	IFT27 RAB33A RAB14	2.60e-03	73	70	3	PS51419
Domain	PDEase_I	PDE6A PDE6C	2.78e-03	21	70	2	PF00233
Domain	PDEASE_I	PDE6A PDE6C	2.78e-03	21	70	2	PS00126
Domain	PDEase_CS	PDE6A PDE6C	2.78e-03	21	70	2	IPR023174
Domain	LSM_dom	SNRPB SNRPN	3.05e-03	22	70	2	IPR010920
Domain	-	PDE6A PDE6C	3.05e-03	22	70	2	1.10.1300.10
Domain	Small_GTPase	CPLANE2 IFT27 RAB33A RAB14	3.07e-03	160	70	4	IPR001806
Domain	PDEase_catalytic_dom	PDE6A PDE6C	3.33e-03	23	70	2	IPR002073
Domain	Small_GTP-bd_dom	CPLANE2 IFT27 RAB33A RAB14	3.57e-03	167	70	4	IPR005225
Domain	HDc	PDE6A PDE6C	3.62e-03	24	70	2	SM00471
Domain	HD/PDEase_dom	PDE6A PDE6C	3.62e-03	24	70	2	IPR003607
Domain	THIOL_PROTEASE_CYS	CAPN3 CAPN11	4.25e-03	26	70	2	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN3 CAPN11	4.57e-03	27	70	2	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN3 CAPN11	4.57e-03	27	70	2	PS00639
Domain	Pept_cys_AS	CAPN3 CAPN11	4.91e-03	28	70	2	IPR000169
Domain	EF-hand_8	CAPN3 CAPN11	7.19e-03	34	70	2	PF13833
Pubmed	A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.	IQSEC3 PDE6A PDE6C HK2 ELOVL2	6.98e-07	81	71	5	16110338
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	PDE12 HK1 COPG1 MED14 NAPA COPG2 TMEM214 NUP160 LRRC41	2.09e-06	560	71	9	35241646
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	HK1 DST COPG1 FRS2 COPG2 ACVR1B EIF4G3 RAB14 NUP160 AP3S2	3.95e-06	777	71	10	35844135
Pubmed	The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein.	SNRPB SNRPN	4.11e-06	2	71	2	8510173
Pubmed	Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury.	HK1 HK2	4.11e-06	2	71	2	24990892
Pubmed	The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury.	HK1 HK2	4.11e-06	2	71	2	21504994
Pubmed	Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci.	SNRPB SNRPN	4.11e-06	2	71	2	10556313
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	HK1 HK2 COPG1 COPG2 UNC45A OGA	8.86e-06	235	71	6	28378594
Pubmed	Activation of the activin A-ALK-Smad pathway in systemic sclerosis.	ACVR1B SMAD3	1.23e-05	3	71	2	21377836
Pubmed	[Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].	HK1 HK2	1.23e-05	3	71	2	26855992
Pubmed	Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress.	HK1 HK2	1.23e-05	3	71	2	21430642
Pubmed	Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2.	HK1 HK2	1.23e-05	3	71	2	30871777
Pubmed	Partial inhibition of activin receptor-like kinase 4 alleviates bladder fibrosis caused by bladder outlet obstruction.	ACVR1B SMAD3	1.23e-05	3	71	2	34237300
Pubmed	Effect of Increased IL-1β on Expression of HK in Alzheimer's Disease.	HK1 HK2	1.23e-05	3	71	2	33525649
Pubmed	A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'.	SNRPB SNRPN	1.23e-05	3	71	2	2522186
Pubmed	Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.	HK1 HK2	1.23e-05	3	71	2	19049977
Pubmed	A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.	HK1 HK2	1.23e-05	3	71	2	20347420
Pubmed	Sm and Sm-like proteins belong to a large family: identification of proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs.	SNRPB SNRPN	1.23e-05	3	71	2	7744014
Pubmed	Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.	ACVR1B SMAD3	1.23e-05	3	71	2	18039968
Pubmed	c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.	HK1 HK2	1.23e-05	3	71	2	28054552
Pubmed	Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesis.	IGF1R SMAD3	1.23e-05	3	71	2	23736539
Pubmed	Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus.	COPG1 COPG2	1.23e-05	3	71	2	11893085
Pubmed	Overview of PDEs and their regulation.	PDE6A PDE12 PDE6C	1.82e-05	25	71	3	17307970
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	PDE12 HK2 COPG1 COPG2 TMEM214 UNC45A EIF4G3 RAB14 OGA DHRS7B	2.10e-05	942	71	10	31073040
Pubmed	Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.	HK1 HK2	2.46e-05	4	71	2	25904018
Pubmed	Hexokinase activity is required for recruitment of parkin to depolarized mitochondria.	HK1 HK2	2.46e-05	4	71	2	23962723
Pubmed	Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.	PDE6A PDE6C	2.46e-05	4	71	2	23033484
Pubmed	High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3.	HK1 HK2	2.46e-05	4	71	2	25766729
Pubmed	Rod phosphodiesterase-6 (PDE6) catalytic subunits restore cone function in a mouse model lacking cone PDE6 catalytic subunit.	PDE6A PDE6C	2.46e-05	4	71	2	21799013
Pubmed	Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program.	HK1 HK2	2.46e-05	4	71	2	32152094
Pubmed	Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.	COPG1 NAPA RAB14 DHRS7B	2.98e-05	86	71	4	25044020
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP26 PDE12 COPG1 POLR3E UNC45A EIF4G3 OGA TADA3 NUP160 DHRS7B	3.63e-05	1005	71	10	19615732
Pubmed	The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus.	SNRPB SNRPN	4.09e-05	5	71	2	18362360
Pubmed	BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules.	BLOC1S6 AP3S2	4.09e-05	5	71	2	12019270
Pubmed	Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak.	HK1 HK2	4.09e-05	5	71	2	15574336
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	HK1 HK2 COPG1 UNC45A RAB14 SNRPB OGA SNRPN NUP160 LRRC41 DHRS7B	4.61e-05	1257	71	11	37317656
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PBRM1 HK1 DST COPG1 COPG2 EIF4G3 NUP160 FKBP4	5.56e-05	653	71	8	22586326
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	NRDE2 IGF1R COPG1 COPG2 UNC45A EIF4G3 RAB14 SNRPB SNRPN NUP160 FKBP4	5.58e-05	1284	71	11	17353931
Pubmed	Identification and characterization of novel isoforms of COP I subunits.	COPG1 COPG2	6.13e-05	6	71	2	11056392
Pubmed	Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit.	PDE6A PDE6C	6.13e-05	6	71	2	19798052
Pubmed	Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia.	IGF1R SMAD3	6.13e-05	6	71	2	16886151
Pubmed	Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum.	COPG1 COPG2	6.13e-05	6	71	2	11884415
Pubmed	Polyglutamine tracts regulate beclin 1-dependent autophagy.	ATXN3L BECN1	6.13e-05	6	71	2	28445460
Pubmed	Inhibins are the major activin ligands expressed during early thymocyte development.	ACVR1B SMAD3	6.13e-05	6	71	2	16477644
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	PBRM1 PDE12 DST NAPA EIF4G3 SNRPB FKBP4	7.14e-05	498	71	7	36634849
Pubmed	Roles of pathway-specific and inhibitory Smads in activin receptor signaling.	ACVR1B SMAD3	8.57e-05	7	71	2	9892009
Pubmed	The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors.	ACVR1B SMAD3	8.57e-05	7	71	2	11927552
Pubmed	TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose.	BECN1 EPG5	8.57e-05	7	71	2	29996716
Pubmed	A novel function for human factor C1 (HCF-1), a host protein required for herpes simplex virus infection, in pre-mRNA splicing.	SNRPB SNRPN	8.57e-05	7	71	2	12456665
Pubmed	Localization of activin and inhibin subunits, receptors and SMADs in the mouse mammary gland.	ACVR1B SMAD3	8.57e-05	7	71	2	12782414
Pubmed	Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.	HK1 HK2	8.57e-05	7	71	2	18165236
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	PDE12 HK1 COPG1 MED14 COPG2 EIF4G3 NUP160 FKBP4	9.38e-05	704	71	8	29955894
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	IFT27 HK2 COPG2 UNC45A OGA NUP160 DHRS7B	1.10e-04	534	71	7	35032548
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	HK1 DST COPG1 COPG2 UNC45A EIF4G3 RAB14 SNRPB OGA FKBP4	1.10e-04	1149	71	10	35446349
Pubmed	Multiple protein: protein interactions between the snRNP common core proteins.	SNRPB SNRPN	1.14e-04	8	71	2	9417867
Pubmed	In vivo assembly of coatomer, the COP-I coat precursor.	COPG1 COPG2	1.14e-04	8	71	2	8940050
Pubmed	Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals.	COPG1 COPG2	1.14e-04	8	71	2	14729954
Pubmed	Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.	HK1 HK2	1.47e-04	9	71	2	19554504
Pubmed	Alternative Splicing Shapes the Phenotype of a Mutation in BBS8 To Cause Nonsyndromic Retinitis Pigmentosa.	PDE6A PDE6C	1.47e-04	9	71	2	25776555
Pubmed	Identification of genes showing altered expression in preimplantation and early postimplantation parthenogenetic embryos.	NAPA SNRPN	1.47e-04	9	71	2	8565329
Pubmed	Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.	HK1 HK2	1.47e-04	9	71	2	21074528
Pubmed	A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer.	COPG1 COPG2	1.47e-04	9	71	2	9751720
Pubmed	COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.	COPG1 COPG2	1.47e-04	9	71	2	10921873
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	DST COPG1 COPG2 ZDBF2 TMEM214 ANO10 UNC45A	1.61e-04	568	71	7	37774976
Pubmed	Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.	IGF1R TTLL4 FRS2 GSDMC	1.77e-04	136	71	4	25429064
Pubmed	Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome region.	IGF1R SNRPN	1.83e-04	10	71	2	1303276
Pubmed	OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor.	USP26 SMAD3	1.83e-04	10	71	2	35484112
Pubmed	Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2.	SNRPB SNRPN	1.83e-04	10	71	2	15105431
Pubmed	Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice.	HK1 HK2	1.83e-04	10	71	2	37545422
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	POLR3E ZDBF2 INTS3 SNRPB NUP160 SMAD3 LRRC41	1.89e-04	583	71	7	29844126
Pubmed	Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.	ACVR1B SMAD3	2.23e-04	11	71	2	19758997
Pubmed	Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.	VPS11 BECN1	2.23e-04	11	71	2	18552835
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	HK1 DST COPG1 COPG2 RAB14 SNRPN FKBP4 EPG5	2.38e-04	807	71	8	30575818
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	FCSK HK2 UNC45A SNRPB SNRPN LRRC41 DHRS7B	2.39e-04	606	71	7	36538041
Pubmed	Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.	ACVR1B SMAD3	2.68e-04	12	71	2	25872870
Pubmed	Identification of four chromosomal loci determining obesity in a multifactorial mouse model.	IGF1R SNRPN	2.68e-04	12	71	2	7706460
Pubmed	The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.	SNRPB SNRPN	2.68e-04	12	71	2	11713266
Pubmed	Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1).	COPG1 COPG2	2.68e-04	12	71	2	10788617
Pubmed	Network organization of the human autophagy system.	HK1 COPG1 NAPA UNC45A BECN1 FKBP4	2.73e-04	437	71	6	20562859
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	DST IPO13 TEX15 SNRPB SNRPN	2.94e-04	284	71	5	29459677
Pubmed	A functional interaction between the survival motor neuron complex and RNA polymerase II.	SNRPB SNRPN	3.16e-04	13	71	2	11149922
Pubmed	Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.	SNRPB SNRPN	3.68e-04	14	71	2	10725331
Pubmed	Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic beta-cells.	ACVR1B SMAD3	3.68e-04	14	71	2	15277382
Pubmed	Age-regulated function of autophagy in the mouse inner ear.	IGF1R BECN1	4.24e-04	15	71	2	26235979
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	HK1 COPG2 EIF4G3 SNRPB OGA LRRC41 DHRS7B	4.36e-04	670	71	7	22990118
Pubmed	Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.	HK1 COPG1 SNRPN	4.40e-04	72	71	3	36012204
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	PDE12 HK1 COPG1 NAPA ANO10 RAB14 INTS3 SNRPB NUP160 FKBP4	4.44e-04	1367	71	10	32687490
Pubmed	Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus.	IGF1R SNRPN	4.84e-04	16	71	2	8601494
Pubmed	Probing nuclear pore complex architecture with proximity-dependent biotinylation.	TMEM214 UNC45A NUP160	5.35e-04	77	71	3	24927568
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	PBRM1 HK2 COPG1 INTS3 NUP160	5.98e-04	332	71	5	32786267
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ADCY4 PBRM1 PDE12 HK1 HK2 COPG1 UNC45A SNRPB NUP160 FKBP4	6.13e-04	1425	71	10	30948266
Pubmed	Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.	NUP160 LRRC41	6.16e-04	18	71	2	26598607
Pubmed	The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.	BLOC1S6 AP3S2	6.16e-04	18	71	2	21998198
Pubmed	Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice.	IGF1R SV2B	6.16e-04	18	71	2	31541165
Pubmed	Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.	SV2B ACVR1B	6.16e-04	18	71	2	24939585
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PDE6A HK1 DST ANKRD30B EIF4G3 RAB14 SNRPB SNRPN DHRS7B CAPN11	6.72e-04	1442	71	10	35575683
Pubmed	ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.	VPS11 BECN1	6.87e-04	19	71	2	33422265
Pubmed	Secretory protein trafficking and organelle dynamics in living cells.	BLOC1S6 COPG1 NAPA	7.14e-04	85	71	3	11031247
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF845 IGF1R PBRM1 TMEM214 ANO10 RAB14 INTS3 NUP160 NLK	7.47e-04	1203	71	9	29180619
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	PDE12 DST COPG1 FRS2 MAP3K9 ACVR1B GSDMC	7.60e-04	736	71	7	29676528
Cytoband	15q26.1	SV2B UNC45A AP3S2	8.31e-05	54	71	3	15q26.1
Cytoband	Ensembl 112 genes in cytogenetic band chr15q26	IGF1R SV2B UNC45A AP3S2	3.02e-04	206	71	4	chr15q26
Cytoband	12p13.33	IQSEC3 FKBP4	3.96e-04	19	71	2	12p13.33
Cytoband	1p34.1	IPO13 LRRC41	3.56e-03	57	71	2	1p34.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1p33	CYP4B1 LRRC41	4.07e-03	61	71	2	chr1p33
GeneFamily	RAB, member RAS oncogene GTPases	IFT27 RAB33A RAB14	5.29e-04	65	44	3	388
GeneFamily	C2 domain containing\|Calpains	CAPN3 CAPN11	5.96e-04	15	44	2	975
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K9 MAP3K19	1.54e-03	24	44	2	654
GeneFamily	Phosphodiesterases	PDE6A PDE6C	1.54e-03	24	44	2	681
Coexpression	GSE17721_LPS_VS_GARDIQUIMOD_12H_BMDC_UP	IFT27 BLOC1S6 HK1 HK2 COPG2 TMEM214 TADA3	1.15e-06	199	71	7	M4058
Coexpression	GSE43863_NAIVE_VS_LY6C_INT_CXCR5POS_CD4_EFF_TCELL_D6_LCMV_DN	VPS11 RAB33A PDE6A SV2B GSDMC MYBPC3	1.46e-05	194	71	6	M9732
Computational	Genes in the cancer module 205.	ADCY4 BLOC1S6 CYP4B1 TTLL4 PPM1E DENND5A WDR47	2.15e-04	305	44	7	MODULE_205
Disease	glucose metabolism disease (implicated_via_orthology)	IGF1R HK1 HK2	3.68e-05	28	68	3	DOID:4194 (implicated_via_orthology)
Disease	hereditary spastic paraplegia 76 (implicated_via_orthology)	CAPN3 CAPN11	5.21e-05	5	68	2	DOID:0110821 (implicated_via_orthology)
Disease	X-24748 measurement	EPHX2 CYP4B1	1.45e-04	8	68	2	EFO_0022136
Disease	tauopathy (implicated_via_orthology)	SNRPB SNRPN	2.33e-04	10	68	2	DOID:680 (implicated_via_orthology)
Disease	ecosanoids measurement	EPHX2 CYP4B1 ELOVL2	2.82e-04	55	68	3	EFO_0020044
Disease	hypertrophic cardiomyopathy (is_marker_for)	IGF1R BECN1	6.96e-04	17	68	2	DOID:11984 (is_marker_for)
Disease	left ventricular mass	IGF1R MYBPC3	7.82e-04	18	68	2	EFO_0009289
Disease	neuroticism measurement, wellbeing measurement, depressive symptom measurement	ACVR1B EIF4G3	8.72e-04	19	68	2	EFO_0007006, EFO_0007660, EFO_0007869
Disease	intrahepatic cholangiocarcinoma (is_marker_for)	PBRM1 BECN1	8.72e-04	19	68	2	DOID:4928 (is_marker_for)
Disease	Lewy Body Disease	IGF1R BECN1	1.17e-03	22	68	2	C0752347
Disease	retinitis pigmentosa (implicated_via_orthology)	PDE6A EPG5	1.77e-03	27	68	2	DOID:10584 (implicated_via_orthology)
Disease	lung small cell carcinoma (is_implicated_in)	PBRM1 ACVR1B	1.90e-03	28	68	2	DOID:5409 (is_implicated_in)
Disease	pancreatic cancer (is_implicated_in)	IGF1R ACVR1B SMAD3	2.23e-03	112	68	3	DOID:1793 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MSELKDCPLQFHDFK	TADA3	1	O75528
FLAHCLDQLKDNMEK	USP26	386	Q9BXU7
HLCKAAFQLMQEDCI	EPG5	1171	Q9HCE0
SENDLFHENCMLKKE	ANKRD30B	1076	Q9BXX2
LDETINMKHFDSFKC	ACVR1B	386	P36896
LSDFQHDLLACSMEK	GSDMC	406	Q9BYG8
FENVCELDLIFHMDK	AP3S2	101	P59780
ALFQDCMNASIHFLK	AADACL4	161	Q5VUY2
LFGKFDQIAKEHECM	ADCY4	301	Q8NFM4
DDMDQDFLHLFKIVA	CAPN11	566	Q9UMQ6
CLLHQFTEKKFMADC	RAB14	26	P61106
ALKFADAHNMLLFET	RAB33A	166	Q14088
QASCDEAHKMKFSDL	INTS3	956	Q68E01
DDFLTMAECQFIIKH	ANO10	116	Q9NW15
DHLECDLNLMFENAK	PBRM1	446	Q86U86
LNVHMEVCAAFEAKE	DST	6526	Q03001
DHAMVAFLDCVQQFK	BECN1	366	Q14457
LFDHIAECLANFMDK	HK2	126	P52789
MDFIFHEKQEGFLCA	ATXN3L	1	Q9H3M9
EFLNEASVMKEFNCH	IGF1R	1046	P08069
NHFFCEMLSLLKLAC	OR2V2	176	Q96R30
EEERCNMSLTHFFKL	PDE12	526	Q6L8Q7
DLEALAMVTAAFCHD	PDE6A	586	P16499
EAFAMLAAAFCHDID	PDE6C	591	P51160
EEAMFALFLQQCHFL	NRDE2	466	Q9H7Z3
LKMLCFFKHDNVLSA	NLK	186	Q9UBE8
LFDHVAECLGDFMEK	HK1	126	P19367
VLHFCALGSDEMQKF	IQSEC3	956	Q9UPP2
AFNKVLAHFVAMCDT	MED14	636	O60244
DKHVCIPDFNMLFNL	PPM1E	246	Q8WY54
DHMLLACMENTDAFL	CPLANE2	126	Q9BU20
QLSLFFDILHCMAEN	FCSK	261	Q8N0W3
EMENFEAPFHCLAKQ	IFT27	156	Q9BW83
CELKMHFDFLIESCQ	EPHX2	141	P34913
MEHLKAFDDEINAFL	ELOVL2	1	Q9NXB9
IFAFKCARAEELFNM	FRS2	86	Q8WU20
LFDFIESCLRNKHEM	COPG2	251	Q9UBF2
FASFIDNKIMCHDDD	DENND5A	581	Q6IQ26
KFKECHSMLDINALF	BLOC1S6	91	Q9UL45
KSFDIFCDVGHMALN	CYP4B1	176	P13584
LFDFIESCLRNKHEM	COPG1	251	Q9Y678
KHATQAFFDCLRAEM	DHRS7B	211	Q6IAN0
AMCHLKLQAFSAAIE	FKBP4	326	Q02790
ADKHMNIDFDSFICC	CAPN3	771	P20807
KLCAEDVKDFLEHMA	POLR3E	376	Q9NVU0
KNFCHIRFAEEFMVD	ENOX1	176	Q8TC92
DEFLHINDFKEAMQC	EIF4G3	1231	O43432
LMDCFADILFALNKH	IPO13	881	O94829
DHFSENAADFVRMCL	MAP3K19	1291	Q56UN5
FFEMPKDSFHCLQDN	MAP3K9	411	P80192
QNLFMAVEDHFELCL	SPRING1	156	Q9H741
DCLKAFHSDVAMQDH	TRIM42	261	Q8IWZ5
FKAFDKHMNLILCDC	SNRPN	31	P63162
CHMDLEQDNDFLIYL	SV2B	526	Q7L1I2
FHDMNLADCQSEVLF	LRRC41	651	Q15345
CRSFALLFDDIDHNM	OGA	166	O60502
LLFDDIDHNMCAADK	OGA	171	O60502
FKAFDKHMNLILCDC	SNRPB	31	P14678
FFKAALCHFCIDMLN	NAPA	206	P54920
DAFIFALCQDHKLRM	NUP160	296	Q12769
CFQEMEKDIHDFEFQ	ZNF845	86	Q96IR2
FSCAFEQKMLNIHVD	WDR47	256	O94967
DVFDKALVLCQMHDF	VPS11	661	Q9H270
VNDKLMRFFDHCEKF	MINPP1	221	Q9UNW1
HELRAMELCEFAFNM	SMAD3	101	P84022
MCHKADVELLQAFGD	TRIM51	236	Q9BSJ1
FFDHCLFTMLQELDK	TMEM214	196	Q6NUQ4
IAKNHEEFFSNMDCT	ZDBF2	326	Q9HCK1
FCFVKDVHPDLEMND	TEX15	2516	Q9BXT5
CHELFGFDIMLDENL	TTLL4	886	Q14679
AACHLLQVMFDALKE	UNC45A	256	Q9H3U1
FACNLSAKLHFMEVK	MYBPC3	621	Q14896