Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

4.50e-085343GO:0030156
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

PHOSPHO2 LIPA H6PD PGAP3 PTPRJ PLBD2

2.18e-03807346GO:0016788
GeneOntologyMolecularFunctionphosphatidylinositol-3,4,5-trisphosphate binding

PLEKHB2 MAPKAP1

3.15e-0349342GO:0005547
GeneOntologyMolecularFunctionphosphatidylinositol phosphate binding

PLEKHB2 MAPKAP1 ARHGAP32

4.65e-03199343GO:1901981
GeneOntologyBiologicalProcessneuromuscular synaptic transmission

RIMBP3 RIMBP3C RIMBP3B

2.57e-0536333GO:0007274
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

1.25e-0528343GO:0002177
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B RFX2

4.19e-0819274MP:0009377
MousePhenodetached acrosome

RIMBP3 RIMBP3C RIMBP3B RFX2

1.42e-0644274MP:0009231
MousePhenoabnormal manchette morphology

RIMBP3 RIMBP3C RIMBP3B RFX2

1.56e-0645274MP:0009376
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

8.35e-0621273MP:0008893
MousePhenoabnormal sperm number

RIMBP3 TERB1 RIMBP3C RIMBP3B PUM1 RFX2 SLC25A28 CREM

1.57e-05624278MP:0002673
MousePhenodecreased male germ cell number

RIMBP3 TERB1 RIMBP3C RIMBP3B PUM1 RFX2 SLC25A28 CREM

1.89e-05640278MP:0004901
MousePhenodecreased germ cell number

RIMBP3 TERB1 RIMBP3C RIMBP3B PUM1 RFX2 SLC25A28 CREM

3.15e-05687278MP:0002209
MousePhenooligozoospermia

RIMBP3 RIMBP3C RIMBP3B PUM1 SLC25A28 CREM

7.50e-05384276MP:0002687
MousePhenoabnormal gametes

RIMBP3 TERB1 RIMBP3C RIMBP3B PUM1 RFX2 SLC25A28 CREM

8.14e-05785278MP:0001124
MousePhenoabnormal male germ cell morphology

RIMBP3 TERB1 RIMBP3C RIMBP3B PUM1 RFX2 SLC25A28 CREM

1.53e-04859278MP:0006362
MousePhenokinked sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

1.66e-0456273MP:0009237
MousePhenoabnormal spermatogenesis

RIMBP3 TERB1 RIMBP3C RIMBP3B PUM1 RFX2 SLC25A28 CREM

2.28e-04910278MP:0001156
MousePhenoabnormal acrosome morphology

RIMBP3 RIMBP3C RIMBP3B RFX2

2.31e-04159274MP:0008898
MousePhenoabnormal germ cell morphology

RIMBP3 TERB1 RIMBP3C RIMBP3B PUM1 RFX2 SLC25A28 CREM

2.98e-04946278MP:0002208
MousePhenoabnormal foam cell morphology

RIMBP3 TERB1 RIMBP3C RIMBP3B PUM1 RFX2 SLC25A28 CREM

3.15e-04954278MP:0009840
MousePhenoabnormal sperm nucleus morphology

RIMBP3 RIMBP3C RIMBP3B

3.80e-0474273MP:0009232
MousePhenoabnormal motile cilium morphology

RIMBP3 RIMBP3C RIMBP3B RFX2 RFX3

6.31e-04370275MP:0013206
MousePhenoabnormal gametogenesis

RIMBP3 TERB1 RIMBP3C RIMBP3B PUM1 RFX2 SLC25A28 CREM

6.83e-041070278MP:0001929
MousePhenoabnormal spermatid morphology

RIMBP3 RIMBP3C RIMBP3B RFX2

7.49e-04217274MP:0006380
MousePhenoteratozoospermia

RIMBP3 RIMBP3C RIMBP3B RFX2 CREM

9.81e-04408275MP:0005578
MousePhenoabnormal spermiogenesis

RIMBP3 RIMBP3C RIMBP3B RFX2

1.04e-03237274MP:0001932
DomainRFX_DNA_binding

RFX2 RFX3 ARID2

4.19e-079333PF02257
DomainDNA-bd_RFX

RFX2 RFX3 ARID2

4.19e-079333IPR003150
DomainRFX_DBD

RFX2 RFX3 ARID2

4.19e-079333PS51526
DomainRFX1_trans_act

RFX2 RFX3

9.07e-063332IPR007668
DomainRFX1_trans_act

RFX2 RFX3

9.07e-063332PF04589
DomainSH3_9

RIMBP3 ARHGAP32 RIMBP3C RIMBP3B

1.05e-0578334PF14604
DomainSH3

RIMBP3 ARHGAP32 RIMBP3C FGR RIMBP3B

3.60e-05216335PS50002
DomainSH3

RIMBP3 ARHGAP32 RIMBP3C FGR RIMBP3B

3.60e-05216335SM00326
DomainSH3_domain

RIMBP3 ARHGAP32 RIMBP3C FGR RIMBP3B

3.93e-05220335IPR001452
DomainFN3

RIMBP3 RIMBP3C RIMBP3B PTPRJ

4.02e-04199334PS50853
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

4.65e-0486333IPR011511
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

4.65e-0486333PF07653
DomainFN3_dom

RIMBP3 RIMBP3C RIMBP3B PTPRJ

4.83e-04209334IPR003961
DomainARM-like

TERB1 PUM1 ARID2 LRRK2

1.26e-03270334IPR011989
DomainARM-type_fold

TERB1 PUM1 ARID2 LRRK2

2.88e-03339334IPR016024
DomainFN3

RIMBP3C RIMBP3B PTPRJ

4.19e-03185333SM00060
DomainRhoGAP

ARHGAP32 MYO9A

5.36e-0362332SM00324
DomainRhoGAP

ARHGAP32 MYO9A

5.53e-0363332PF00620
DomainRHOGAP

ARHGAP32 MYO9A

5.70e-0364332PS50238
DomainRhoGAP_dom

ARHGAP32 MYO9A

5.70e-0364332IPR000198
Domain-

ARHGAP32 MYO9A

5.70e-03643321.10.555.10
Domain-

RIMBP3 CD58 RIMBP3C RIMBP3B PTPRJ

5.78e-036633352.60.40.10
Domain-

RFX2 RFX3 ARID2

6.61e-032183331.10.10.10
Domain-

TERB1 PUM1 LRRK2

6.95e-032223331.25.10.10
DomainIg-like_fold

RIMBP3 CD58 RIMBP3C RIMBP3B PTPRJ

7.50e-03706335IPR013783
DomainWHTH_DNA-bd_dom

RFX2 RFX3 ARID2

8.80e-03242333IPR011991
DomainRho_GTPase_activation_prot

ARHGAP32 MYO9A

1.05e-0288332IPR008936
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

3.41e-09434319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

8.52e-09534317855024
Pubmed

G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.

ARHGAP32 RFX2 RFX3

1.40e-071134318218630
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

3.08e-071434317662146
Pubmed

Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.

PUM1 ATXN1

9.28e-07234225768905
Pubmed

Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.

RFX2 RFX3

2.78e-06334215024578
Pubmed

Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.

RFX2 RFX3

2.78e-06334212403718
Pubmed

RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.

RFX2 RFX3

2.78e-0633428289803
Pubmed

Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.

RFX2 RFX3

2.78e-06334210330134
Pubmed

Ciliogenic RFX transcription factors regulate FGF1 gene promoter.

RFX2 RFX3

2.78e-06334222415835
Pubmed

Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.

RFX2 RFX3

2.78e-06334232725242
Pubmed

Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1.

PUM1 ATXN1

2.78e-06334222916034
Pubmed

Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.

RFX2 RFX3

5.56e-06434211682486
Pubmed

Differential expression of Rfx1-4 during mouse spermatogenesis.

RFX2 RFX3

5.56e-06434219596083
Pubmed

Variants in PSMB9 and FGR differentially affect Parkinson's disease risk in GBA and LRRK2 mutation carriers.

FGR LRRK2

5.56e-06434237116292
Pubmed

Rfx2 is required for spermatogenesis in the mouse.

RFX2 CREM

1.94e-05734226248850
Pubmed

RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.

RFX2 RFX3

1.94e-05734222233545
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZFR ATXN1 RFX2 RFX3 CREM ARID2

1.19e-0480834620412781
Pubmed

Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis.

RFX2 RFX3

1.25e-041734231068677
Pubmed

Rfx6 directs islet formation and insulin production in mice and humans.

RFX2 RFX3

1.93e-042134220148032
Pubmed

The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.

RFX2 RFX3

2.12e-042234219887680
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

PLEKHB2 LIPA EPPK1 PARP14

3.02e-0433234437433992
Pubmed

CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression.

PCBP3 H6PD ATXN1

5.44e-0416334323333304
Pubmed

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.

RFX2 CREM

6.38e-043834234059773
Pubmed

Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.

RFX2 RFX3

7.07e-044034232317081
Pubmed

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.

KLHL13 OPLAH

7.07e-044034227760309
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

ARHGAP32 ZFR EPPK1 ARID2

7.97e-0443034435044719
InteractionUBAP2 interactions

PLEKHB2 ZFR PUM1 ATXN1 CREM

6.74e-06170325int:UBAP2
Cytoband22q11.21

RIMBP3 RIMBP3C RIMBP3B

7.79e-0511134322q11.21
Cytoband12q12

ARID2 LRRK2

5.64e-044734212q12
CytobandEnsembl 112 genes in cytogenetic band chr12q12

ARID2 LRRK2

1.01e-0363342chr12q12
Cytoband8q24.3

EPPK1 OPLAH

3.20e-031133428q24.3
CytobandEnsembl 112 genes in cytogenetic band chr22q11

RIMBP3 RIMBP3C RIMBP3B

3.66e-03419343chr22q11
CytobandEnsembl 112 genes in cytogenetic band chr1p35

FGR PUM1

4.66e-03137342chr1p35
GeneFamilyRegulatory factor X family

RFX2 RFX3

4.31e-0582321153
CoexpressionOCONNOR_PBMC_MENVEO_ACWYVAX_AGE_30_70YO_7DY_AFTER_SECOND_DOSE_VS_7DY_AFTER_FIRST_DOSE_DN

PLEKHB2 PHOSPHO2 LIPA PUM1 ARID2

1.47e-05243345M41178
CoexpressionMARTENS_BOUND_BY_PML_RARA_FUSION

CD58 H6PD FGR PTPRJ RFX2 ARID2

2.39e-05456346M2094
CoexpressionAtlasMyeloid Cells, MF.RP.Sp, F4/80hi CD11blo CD11c- autofluorescent, Spleen, avg-3

ARHGAP32 LIPA FGR PTPRJ ATXN1 MYO9A

3.86e-05403346GSM605853_500
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PGAP3 FGR TET3 PLBD2

7.97e-0616834494cded2e953c0970bf2f3dbe0ce46bd77a5ed8c7
ToppCellMild/Remission-B_intermediate-10|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FGR ATXN1 CREM LRRK2

1.12e-05183344278064c9f0582463b83bf156d34e77f60187613b
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LIPA FGR PARP14 LRRK2

1.17e-05185344f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D175|Adult / Lineage, Cell type, age group and donor

MAPKAP1 CD58 FGR PTPRJ

1.35e-05192344733491e932350e3c216a626cc49c3cd3fe970a82
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRJ RFX2 MYO9A KLHL13

1.38e-05193344f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRJ RFX2 MYO9A KLHL13

1.38e-0519334442df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRJ MYO9A KLHL13 LRRK2

1.40e-05194344e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellCOVID-19-Myeloid-Monocytes|COVID-19 / group, cell type (main and fine annotations)

FGR PTPRJ TET3 LRRK2

1.46e-0519634404d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCellNS-critical-LOC|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PLEKHB2 FGR PARP14 CREM

1.52e-05198344ff9b9065f5d91a7aff99121bddc3e86f6b1c8a8d
ToppCellBronchus_Control_(B.)-Immune-TX-MoAM-3|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

SLC46A2 FGR PTPRJ PLBD2

1.52e-051983441d92b09aeb03a95fa9e221813002045c4f41dd24
ToppCellmild-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FGR PARP14 TET3 LRRK2

1.58e-05200344934c2efc780318c66d667ca75be0de350361d351
ToppCellcontrol-Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SLC46A2 LIPA FGR LRRK2

1.58e-05200344251ca08fab5cc2a4e280db6a6286a9ebaef3e61a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PHOSPHO2 MYO9A LRRK2

1.48e-041353438521107817df49efd9a2e81078c8535ed33e729c
ToppCellMild/Remission-B_intermediate-10|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FGR CREM LRRK2

1.51e-041363431b3c6edcbe0eb674d2d9c838e83ebe2b93e3eec1
ToppCellControl-B_intermediate-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FGR PTPRJ LRRK2

1.94e-04148343662c057030effc9eb61216e81d3967e6983c244f
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHB2 FGR MYO9A

2.30e-04157343ec433d2fe827abdb647be4176c231b7052482b6f
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PGAP3 PTPRJ RFX2

2.44e-041603435d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCellfacs-Thymus-Epithelium-3m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC46A2 EPPK1 MKRN2OS

2.53e-0416234325323785dd33337bcefd05958a4a1a208a9ceb04
ToppCellfacs-Thymus-Epithelium-3m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC46A2 EPPK1 MKRN2OS

2.53e-041623433dc39db0d5f6f3d7bcc312a6bce7aaeb914138d1
ToppCellfacs-Thymus-Epithelium-3m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC46A2 EPPK1 MKRN2OS

2.53e-041623430a7138266054ea5954649c8b61ef93905d56b068
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PCBP3 RFX3 TET3

2.53e-0416234364353d33af0e82ebb7cf2bba74d52ca0586a58fc
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHB2 FGR MYO9A

2.57e-041633438dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PCBP3 RFX3 TET3

2.57e-041633439f5facfa1864eb63e2f8022ad7379d9252b7a254
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHB2 FGR MYO9A

2.57e-04163343fd243ca223079033be480a24817a399f281fa4d4
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

SLC46A2 EPPK1 LRRK2

2.62e-0416434385f53d184fa70e3eb1af655807f32b17ddbfb304
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

SLC46A2 EPPK1 LRRK2

2.62e-04164343144ba070a1ede71684224cc6d4ead3b7e6a7b4c6
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PARP14 TET3 LRRK2

2.91e-0417034307b561cd9c528bc8444c9385e1de621eee7b697e
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|368C / Donor, Lineage, Cell class and subclass (all cells)

PTPRJ RFX2 TET3

2.96e-0417134326b34dc069cc15b75a0c13cb8c5d81e074788160
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RIMBP3C LIPA TET3

2.96e-04171343b520d4d5620cac08315e4cbb7e796c5e9e233060
ToppCellwk_20-22-Hematologic-Myeloid-CXCL9+_Mac|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PARP14 SLC25A28 LRRK2

3.17e-0417534348f5bdbfc1ba40c3fb6411f12a69e61da2138296
ToppCell10x5'v1-week_14-16-Myeloid_macrophage-stroma-monocytoid_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SLC46A2 LIPA CREM

3.27e-04177343945b2d0723a0a35c767604ae607d2c2d53bf0c82
ToppCellSevere-B_intermediate-10|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FGR ATXN1 LRRK2

3.33e-04178343b7374a97c51239782bed658381a02cb1b3d9bf66
ToppCellLPS-antiTNF-Myeloid-Neutrophils-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHB2 FGR PTPRJ

3.33e-04178343afcc92e8fe313c85eaf617cf4dbc3058da6c99d6
ToppCellLPS-antiTNF-Myeloid-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHB2 FGR PTPRJ

3.33e-04178343bd689205bc92cda5f71df64c2332ff76adcd84b4
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RIMBP3 RIMBP3C RIMBP3B

3.33e-0417834339889db130216655a34796e7030ffeb372465500
ToppCellLPS_only-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LIPA FGR PTPRJ

3.38e-04179343dc03b9045510eb1bb934329646bb92dd06890ce9
ToppCellLPS_only-Myeloid-Neutrophils|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHB2 FGR PTPRJ

3.38e-04179343d0a03e498afcfeb657037889685ecd77bed07e6c
ToppCellLPS_only-Myeloid-Monocytes,_Macrophages|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LIPA FGR PTPRJ

3.38e-04179343330c1326ba93bb8f32559ee1cc40e357cc44ad8d
ToppCellLPS_only-Myeloid-Neutrophils-Neutrophils|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHB2 FGR PTPRJ

3.38e-04179343d034651a5a355a58f5e15db627869f4feebdfe35
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FGR TET3 LRRK2

3.44e-0418034366c7b02d85e32ba3e7530d0c4aff17e7525ccdd8
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-FCRL4+_Memory_B|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FGR PARP14 LRRK2

3.44e-04180343eedb6d89680f968167afb1dcd132c9de9096b50f
ToppCellfacs-Marrow-T-cells-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHOSPHO2 ATXN1 CREM

3.50e-0418134357f0cc749ae8b6a3d77e2af31f9a6e4739c57049
ToppCellfacs-Marrow-T-cells-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHOSPHO2 ATXN1 CREM

3.50e-04181343d01b35cc2fc57991a35be6a06cb7351fbabd9a11
ToppCellLPS_only-Myeloid|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHB2 FGR PTPRJ

3.55e-04182343666ac86ee5f6fa9241ae8d80340743707e54b278
ToppCellfacs-Thymus-Flowthrough-24m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGR PTPRJ LRRK2

3.61e-041833430513bb73552bfee609877d924fa97684200f595c
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LIPA FGR PLBD2

3.61e-041833434cc0961a67de76b8d756cd9ffcaa98e3fe3c3a69
ToppCellfacs-Thymus-Flowthrough-24m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGR PTPRJ LRRK2

3.61e-0418334385b2335fa938a94e74251bd8d99de1bd21265ac9
ToppCellfacs-Thymus-Flowthrough-24m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGR PTPRJ LRRK2

3.61e-041833436eeef55071ae25a61616df4fcfb2cea560aa7923
ToppCellfacs-Marrow-T-cells-3m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATXN1 PLBD2 CREM

3.61e-04183343b0b835f3b1de1bd46a47e1b805aa8994cd3a4e3e
ToppCellB_cells-ISG-high_B_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

PARP14 SLC25A28 RFX3

3.61e-04183343dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RFX2 KLHL13 LRRK2

3.67e-041843438fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC46A2 ARHGAP32 LRRK2

3.73e-041853430d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FGR RFX2 PLBD2

3.73e-041853437bff05d8d34616adbaa0ea0b69eb30aa906bb9f8
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC46A2 ARHGAP32 LRRK2

3.79e-04186343e83718fabb057100835d3357df407f283d23fe16
ToppCellLPS-antiTNF-Myeloid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHB2 FGR PTPRJ

3.79e-04186343839c6da5244f469461b2e5563e36162b2911cd01
ToppCell3'_v3-GI_small-bowel-Myeloid_Monocytic-Nonclassical_monocytes|GI_small-bowel / Manually curated celltypes from each tissue

SLC46A2 FGR LRRK2

3.85e-04187343c20689022569640ebc4a878e3fe146b86fe9b386
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC46A2 ARHGAP32 LRRK2

3.91e-041883434bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A KLHL13 LRRK2

3.91e-0418834363a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO9A ARID2 LRRK2

3.91e-041883436468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO9A ARID2 LRRK2

3.91e-041883437a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO9A ARID2 LRRK2

3.91e-041883439cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CD58 FGR CREM

3.91e-04188343ef3f6400c018834a8fd56893faa3476a0f10aedc
ToppCelldroplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLEKHB2 LIPA ATXN1

3.97e-04189343b2542b6fcf7bc10d29158d42b03182a939ff135a
ToppCell3'_v3-GI_small-bowel-Myeloid_Monocytic-Classical_monocytes|GI_small-bowel / Manually curated celltypes from each tissue

SLC46A2 FGR LRRK2

3.97e-0418934374a5e61cd820f2495dde40e766c771a31d8c4e7d
ToppCellControl-B_intermediate-6|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FGR PTPRJ LRRK2

3.97e-0418934311cb9a16f1de8f60af2073ed7ea6d4f41c02f299
ToppCelldroplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLEKHB2 LIPA ATXN1

4.03e-04190343da58227565ad6a690828dd8554dd3670222f8582
ToppCell10x5'-Lung-Myeloid_Monocytic-Classical_monocytes|Lung / Manually curated celltypes from each tissue

SLC46A2 FGR LRRK2

4.03e-04190343a2574f0876ebae3a1d2a39a79cc6cadac8ee1688
ToppCellBAL-Control-Lymphocyte-B-B_cell|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PCBP3 CREM LRRK2

4.03e-04190343da7341a8a423e5fe4d8e733d8e50c10a3318ac1c
ToppCellBAL-Control-Lymphocyte-B-B_cell-B_cell-B_activate-7|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PCBP3 CREM LRRK2

4.03e-04190343682418a7a2096743112eae3790d40e7e600612c0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A KLHL13 LRRK2

4.03e-041903433fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellBAL-Control-Lymphocyte-B-B_cell-B_cell|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PCBP3 CREM LRRK2

4.03e-0419034342312f7d79fe889397d32910b625793e2535cc26
ToppCellLV-08._Macrophage|World / Chamber and Cluster_Paper

FGR PTPRJ TET3

4.09e-04191343e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC46A2 FGR LRRK2

4.09e-0419134363d4226a8b59f648bdc9f41e4b2d750dfa342034
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FGR TET3 LRRK2

4.09e-0419134347a2afc4102199b4bc76bd01b2967c8016186462
ToppCellControl-B_intermediate-10|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FGR ATXN1 CREM

4.15e-04192343224bd958369ba8fa0d7be2126f7dc61c9f6ac19d
ToppCell15-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

ARHGAP32 RFX2 RFX3

4.15e-041923439cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCelltumor_Lung-Fibroblasts-Undetermined|Fibroblasts / Location, Cell class and cell subclass

FGR PTPRJ CREM

4.22e-041933438cc7172c327a9cf6823e1a35322a4e5960826ec8
ToppCell10x5'-Lung-Myeloid_Monocytic|Lung / Manually curated celltypes from each tissue

SLC46A2 FGR LRRK2

4.22e-04193343ebe6be10ef5de9e1da988e263106698d3db42fce
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

CD58 RFX2 KLHL13

4.22e-04193343ca7c0a4ceb05bced90f6cdc53d278e547fb241e9
ToppCellCD8+_Memory_T_cell-CV-0|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

FGR PTPRJ ATXN1

4.22e-04193343995781d87a919c0380750878bafe584342bb83ad
ToppCellCF-Lymphoid-B_cell|Lymphoid / Disease state, Lineage and Cell class

CD58 PARP14 LRRK2

4.22e-041933437ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

PUM1 RFX3 ARID2

4.22e-04193343e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CD58 LIPA CREM

4.22e-04193343ed44c3192e80134d58b72f1659cd66baf16cfd86
ToppCellCOVID-19-Heart-Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

FGR PTPRJ TET3

4.28e-04194343f09675cd472200363c458952f00d2e41990800ee
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC46A2 FGR LRRK2

4.28e-04194343b191851b2287afc8c47320f5488fd22e2a454aa6
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B-ABC_aged-B_memory|lymph-node_spleen / Manually curated celltypes from each tissue

FGR PARP14 LRRK2

4.28e-04194343b57ae94a092b58623a244a258b4659a3864542c7
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Cajal_Retzius-36|World / Primary Cells by Cluster

PLEKHB2 PCBP3 KLHL13

4.35e-04195343bc76a0586cc78f013cb96a2444e63e3c5daa3bc7
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRJ MYO9A KLHL13

4.35e-041953436477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

PARP14 SLC25A28 RFX3

4.35e-04195343b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FGR PTPRJ TET3

4.35e-041953439d649ac7d2af313481069c95349efc0c68449e2b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Cajal_Retzius|World / Primary Cells by Cluster

PLEKHB2 PCBP3 KLHL13

4.35e-04195343424d8e2bc7f7e68f74219de06dbbb671c8b4c24c
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

FGR PTPRJ TET3

4.41e-04196343cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

PTPRJ ATXN1 MYO9A

4.41e-04196343ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellcontrol-Others-Megakaryocytes|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

FGR PTPRJ LRRK2

4.41e-0419634310d914f1612622f64ac71da04e1995a854a4bec9
ToppCellCOVID-19-kidney-TAL|kidney / Disease (COVID-19 only), tissue and cell type

MYO9A KLHL13 LRRK2

4.41e-0419634304f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRJ MYO9A LRRK2

4.41e-041963436ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-intermediate_monocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LIPA FGR LRRK2

4.41e-04196343894f9943404cf252dbdf9e5769d9238f982ba8b8
ToppCellcontrol-Myeloid-Non-resident_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

LIPA PUM1 LRRK2

4.48e-04197343df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

FGR PTPRJ TET3

4.48e-04197343e42910a653a1b5bd90c090e9665a84871ed2873f
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRJ MYO9A LRRK2

4.48e-041973437e93a97b5ac5ae2f77a4b3141082a1463fed00dd
DiseaseAbnormality of the face

PUM1 TET3

3.58e-059302C4025871
Diseasemammographic density percentage

ATXN1 TET3

3.99e-0429302EFO_0006502
DiseaseChloracne

EPPK1 CREM

5.17e-0433302C0263454
Diseasesex interaction measurement, Crohn's disease

PGAP3 LRRK2

6.51e-0437302EFO_0000384, EFO_0008343
Diseasemacula measurement

ARHGAP32 PCBP3 MYO9A

9.24e-04189303EFO_0008375
Diseasemammographic density measurement

ATXN1 TET3

1.19e-0350302EFO_0005941
Diseaseneutrophil count, eosinophil count

LIPA PTPRJ ATXN1

1.30e-03213303EFO_0004833, EFO_0004842
Diseaseautoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis

SLC25A28 LRRK2

2.31e-0370302EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
Diseasefibrinogen measurement

SLC46A2 LIPA

5.50e-03109302EFO_0004623
Diseasesleep duration

MAPKAP1 PUM1 PTPRJ

5.82e-03362303EFO_0005271
Diseasecolorectal cancer (is_implicated_in)

PTPRJ ARID2

6.73e-03121302DOID:9256 (is_implicated_in)
DiseaseGlobal developmental delay

PUM1 TET3

8.08e-03133302C0557874
Diseasesystemic lupus erythematosus

CD58 ATXN1 TET3 MKRN2OS

8.35e-03799304MONDO_0007915

Protein segments in the cluster

PeptideGeneStartEntry
AVYVVYTGDVNVNGQ

ALG11

96

Q2TAA5
QVVYQVASNQAAGFG

ARID2

1096

Q68CP9
VIGYLSGQQQAITYA

ATXN1

461

P54253
GSSNGVQVTGYAVYA

RIMBP3B

1116

A6NNM3
GSSNGVQVTGYAVYA

RIMBP3C

1116

A6NJZ7
YNATVYSQAANGTEG

PTPRJ

341

Q12913
QQIYGVVYGNVTFHV

CD58

31

P19256
GGYYITTRVQFNSVQ

FGR

206

P09769
YQVGGVTAYFRGVQA

SLC25A28

316

Q96A46
GNVIYNQQADVYSFG

LRRK2

2046

Q5S007
QAGYTNYGDIAVATT

ARHGAP32

1066

A7KAX9
QQGVNYTQIVYIGDG

PHOSPHO2

166

Q8TCD6
FAGGQAYTIQGQYAI

PCBP3

221

P57721
AAYYDQTGALVVNAG

PUM1

556

Q14671
AVAYGKGTYFAVNAN

PARP14

1706

Q460N5
VIGNFLYVVGGQSNY

KLHL13

386

Q9P2N7
GSAVVGQYQSYSEQV

H6PD

306

O95479
IYQTSTGQYIAIAQG

CREM

161

Q03060
YGYNLVANVAIGLVN

PGAP3

221

Q96FM1
GTQVVYAANGQAYAV

PLEKHB2

156

Q96CS7
QVQYVEGGDAVYTNG

RFX2

71

P48378
QVQYVEGSDTVYTNG

RFX3

56

P48380
GSSNGVQVTGYAVYA

RIMBP3

1116

Q9UFD9
AGGVVGYSATTYQQE

OPLAH

291

O14841
VYVEASGQAQSVYAA

EPPK1

46

P58107
GSNGETQGYVYAQSV

MAPKAP1

56

Q9BPZ7
LHVGITNTNGVVYNY

MKRN2OS

81

H3BPM6
TNTNGVVYNYSAHGV

MKRN2OS

86

H3BPM6
YSGNAVVESYSVLGN

TET3

1231

O43151
KAGYSQGATQYTQAQ

ZFR

191

Q96KR1
NQVQVGYGMAAGYTI

SLC46A2

316

Q9BY10
SGQYNDSLQAYAAGV

PLBD2

106

Q8NHP8
ANNTYVQKYFVSVGG

TERB1

231

Q8NA31
NKTGQEQVYYVGHSQ

LIPA

161

P38571
QVNYQETGTVLGAYV

MYO9A

301

B2RTY4