Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium channel activity	GRIK2 GRIK3 NALCN SCN2A SCN3A SCN9A	2.73e-07	52	103	6	GO:0005272
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC17A3 GRIK2 GRIK3 SLC5A11 NALCN SCN2A SCN3A SCN9A	2.92e-06	171	103	8	GO:0015081
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	NALCN SCN2A SCN3A SCN9A	9.15e-06	26	103	4	GO:0005248
GeneOntologyMolecularFunction	sodium ion binding	SCN2A SCN3A SCN9A	4.66e-05	14	103	3	GO:0031402
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIA1 GRIK2 GRIK3	8.60e-05	17	103	3	GO:0004970
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC17A3 GRIA1 GRIK2 GRIK3 SLC5A11 CACNG6 NALCN SCN2A SCN3A SCN9A	1.45e-04	465	103	10	GO:0046873
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIA1 GRIK2 GRIK3	2.49e-04	24	103	3	GO:0099507
GeneOntologyMolecularFunction	small GTPase binding	RGPD4 LZTR1 RPH3AL MYCBP2 GRIA1 RPH3A RAB3GAP2 RGPD3	2.59e-04	321	103	8	GO:0031267
GeneOntologyMolecularFunction	alkali metal ion binding	SCN2A SCN3A SCN9A	3.18e-04	26	103	3	GO:0031420
GeneOntologyMolecularFunction	glutamate receptor activity	GRIA1 GRIK2 GRIK3	3.56e-04	27	103	3	GO:0008066
GeneOntologyMolecularFunction	channel activity	SLC17A3 MCL1 GRIA1 GRIK2 GRIK3 CACNG6 NALCN SCN2A SCN3A SCN9A	3.83e-04	525	103	10	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	SLC17A3 MCL1 GRIA1 GRIK2 GRIK3 CACNG6 NALCN SCN2A SCN3A SCN9A	3.89e-04	526	103	10	GO:0022803
GeneOntologyMolecularFunction	kainate selective glutamate receptor activity	GRIK2 GRIK3	3.90e-04	6	103	2	GO:0015277
GeneOntologyMolecularFunction	monoatomic cation channel activity	GRIA1 GRIK2 GRIK3 CACNG6 NALCN SCN2A SCN3A SCN9A	4.03e-04	343	103	8	GO:0005261
GeneOntologyMolecularFunction	GTPase binding	RGPD4 LZTR1 RPH3AL MYCBP2 GRIA1 RPH3A RAB3GAP2 RGPD3	5.55e-04	360	103	8	GO:0051020
GeneOntologyMolecularFunction	monoatomic ion channel activity	SLC17A3 GRIA1 GRIK2 GRIK3 CACNG6 NALCN SCN2A SCN3A SCN9A	6.16e-04	459	103	9	GO:0005216
GeneOntologyMolecularFunction	lysozyme activity	LYZL1 LYZL2	1.41e-03	11	103	2	GO:0003796
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC17A3 GRIA1 GRIK2 GRIK3 SLC5A11 CACNG6 NALCN SCN2A SCN3A SCN9A	1.49e-03	627	103	10	GO:0022890
GeneOntologyMolecularFunction	toxin transmembrane transporter activity	SLC17A3 LRP5	1.68e-03	12	103	2	GO:0019534
GeneOntologyBiologicalProcess	neuronal action potential	GRIA1 GRIK2 SCN2A SCN3A SCN9A	1.57e-05	63	103	5	GO:0019228
GeneOntologyCellularComponent	sodium channel complex	GRIK2 GRIK3 SCN2A SCN3A SCN9A	2.99e-07	29	104	5	GO:0034706
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN2A SCN3A SCN9A	7.73e-05	17	104	3	GO:0001518
GeneOntologyCellularComponent	postsynaptic density membrane	GRIA1 CNKSR2 GRIK2 GRIK3 LRP8 ELFN1	1.35e-04	157	104	6	GO:0098839
GeneOntologyCellularComponent	kainate selective glutamate receptor complex	GRIK2 GRIK3	3.63e-04	6	104	2	GO:0032983
GeneOntologyCellularComponent	postsynaptic specialization membrane	GRIA1 CNKSR2 GRIK2 GRIK3 LRP8 ELFN1	5.09e-04	201	104	6	GO:0099634
GeneOntologyCellularComponent	monoatomic ion channel complex	GRIA1 GRIK2 GRIK3 CACNG6 NALCN SCN2A SCN3A SCN9A	6.04e-04	378	104	8	GO:0034702
GeneOntologyCellularComponent	synaptic membrane	GRIA1 CNKSR2 GRIK2 GRIK3 RPH3A LRP8 ELFN1 SCN2A GPR156 GPR151	6.56e-04	583	104	10	GO:0097060
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RGPD3	6.73e-04	8	104	2	GO:1990723
GeneOntologyCellularComponent	postsynaptic membrane	GRIA1 CNKSR2 GRIK2 GRIK3 RPH3A LRP8 ELFN1 GPR156	9.45e-04	405	104	8	GO:0045211
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD4 RGPD3	1.07e-03	10	104	2	GO:0044614
GeneOntologyCellularComponent	cation channel complex	GRIK2 GRIK3 CACNG6 SCN2A SCN3A SCN9A	1.15e-03	235	104	6	GO:0034703
GeneOntologyCellularComponent	ionotropic glutamate receptor complex	GRIA1 GRIK2 GRIK3	1.46e-03	45	104	3	GO:0008328
GeneOntologyCellularComponent	plasma membrane protein complex	CASP3 GRIA1 GRIK2 GRIK3 CACNG6 SCN2A SKAP1 SCN3A SCN9A GPR156 LRP5	1.82e-03	785	104	11	GO:0098797
GeneOntologyCellularComponent	neurotransmitter receptor complex	GRIA1 GRIK2 GRIK3	1.98e-03	50	104	3	GO:0098878
GeneOntologyCellularComponent	annulate lamellae	RGPD4 RGPD3	2.15e-03	14	104	2	GO:0005642
HumanPheno	Calcaneovalgus deformity	NALCN RAB3GAP2 SCN2A SCN9A	4.01e-05	34	30	4	HP:0001848
HumanPheno	Deformed tarsal bones	NALCN RAB3GAP2 SCN2A SCN9A	4.51e-05	35	30	4	HP:0008119
Domain	Na_trans_cytopl	SCN2A SCN3A SCN9A	3.22e-06	6	103	3	PF11933
Domain	Na_trans_cytopl	SCN2A SCN3A SCN9A	3.22e-06	6	103	3	IPR024583
Domain	-	MYCBP2 HERC2 HERC1 TECPR1	5.91e-06	22	103	4	2.130.10.30
Domain	RCC1/BLIP-II	MYCBP2 HERC2 HERC1 TECPR1	7.13e-06	23	103	4	IPR009091
Domain	Na_channel_asu	SCN2A SCN3A SCN9A	1.90e-05	10	103	3	IPR001696
Domain	Na_trans_assoc	SCN2A SCN3A SCN9A	1.90e-05	10	103	3	IPR010526
Domain	Na_trans_assoc	SCN2A SCN3A SCN9A	1.90e-05	10	103	3	PF06512
Domain	LYZL1/LYZL2	LYZL1 LYZL2	3.01e-05	2	103	2	IPR030057
Domain	TECPR	HERC2 TECPR1	9.00e-05	3	103	2	SM00706
Domain	Beta-propeller_rpt_TECPR	HERC2 TECPR1	9.00e-05	3	103	2	IPR006624
Domain	Lig_chan-Glu_bd	GRIA1 GRIK2 GRIK3	1.25e-04	18	103	3	PF10613
Domain	Glu/Gly-bd	GRIA1 GRIK2 GRIK3	1.25e-04	18	103	3	IPR019594
Domain	Lig_chan-Glu_bd	GRIA1 GRIK2 GRIK3	1.25e-04	18	103	3	SM00918
Domain	Iontro_rcpt	GRIA1 GRIK2 GRIK3	1.25e-04	18	103	3	IPR001320
Domain	Iono_rcpt_met	GRIA1 GRIK2 GRIK3	1.25e-04	18	103	3	IPR001508
Domain	Lig_chan	GRIA1 GRIK2 GRIK3	1.25e-04	18	103	3	PF00060
Domain	PBPe	GRIA1 GRIK2 GRIK3	1.25e-04	18	103	3	SM00079
Domain	RCC1	MYCBP2 HERC2 HERC1	1.73e-04	20	103	3	PF00415
Domain	GPCR_chapero_1	ANKRD13D ANKRD13A	1.79e-04	4	103	2	PF11904
Domain	ANKRD13	ANKRD13D ANKRD13A	1.79e-04	4	103	2	IPR021832
Domain	RCC1_1	MYCBP2 HERC2 HERC1	2.02e-04	21	103	3	PS00625
Domain	RCC1_2	MYCBP2 HERC2 HERC1	2.02e-04	21	103	3	PS00626
Domain	RCC1_3	MYCBP2 HERC2 HERC1	2.02e-04	21	103	3	PS50012
Domain	Reg_chr_condens	MYCBP2 HERC2 HERC1	2.32e-04	22	103	3	IPR000408
Domain	Channel_four-helix_dom	NALCN SCN2A SCN3A SCN9A	2.75e-04	57	103	4	IPR027359
Domain	-	NALCN SCN2A SCN3A SCN9A	2.75e-04	57	103	4	1.20.120.350
Domain	YTH	YTHDF1 YTHDF2	2.98e-04	5	103	2	PF04146
Domain	YTH_domain	YTHDF1 YTHDF2	2.98e-04	5	103	2	IPR007275
Domain	YTH	YTHDF1 YTHDF2	2.98e-04	5	103	2	PS50882
Domain	HELP	EML6 EML5	4.45e-04	6	103	2	PF03451
Domain	HELP	EML6 EML5	4.45e-04	6	103	2	IPR005108
Domain	APC_su10/DOC_dom	MYCBP2 HERC2	6.21e-04	7	103	2	IPR004939
Domain	Glyco_hydro_22_lys	LYZL1 LYZL2	6.21e-04	7	103	2	IPR000974
Domain	Glyco_hydro_22_CS	LYZL1 LYZL2	6.21e-04	7	103	2	IPR019799
Domain	DOC	MYCBP2 HERC2	6.21e-04	7	103	2	PS51284
Domain	Rab_bind	RGPD4 RGPD3	6.21e-04	7	103	2	PF16704
Domain	ANAPC10	MYCBP2 HERC2	6.21e-04	7	103	2	PF03256
Domain	GCC2_Rab_bind	RGPD4 RGPD3	6.21e-04	7	103	2	IPR032023
Domain	APC10	MYCBP2 HERC2	6.21e-04	7	103	2	SM01337
Domain	Glyco_hydro_22	LYZL1 LYZL2	8.25e-04	8	103	2	IPR001916
Domain	LACTALBUMIN_LYSOZYME_2	LYZL1 LYZL2	8.25e-04	8	103	2	PS51348
Domain	Lys	LYZL1 LYZL2	8.25e-04	8	103	2	PF00062
Domain	LACTALBUMIN_LYSOZYME_1	LYZL1 LYZL2	8.25e-04	8	103	2	PS00128
Domain	LYZ1	LYZL1 LYZL2	8.25e-04	8	103	2	SM00263
Domain	ANF_lig-bd_rcpt	GRIA1 GRIK2 GRIK3	1.10e-03	37	103	3	IPR001828
Domain	ANF_receptor	GRIA1 GRIK2 GRIK3	1.10e-03	37	103	3	PF01094
Domain	Peripla_BP_I	GRIA1 GRIK2 GRIK3	1.29e-03	39	103	3	IPR028082
Domain	Lysozyme-like_dom	LYZL1 LYZL2	1.32e-03	10	103	2	IPR023346
Domain	-	RGPD4 RGPD3	1.32e-03	10	103	2	1.10.220.60
Domain	Grip	RGPD4 RGPD3	1.60e-03	11	103	2	SM00755
Domain	GRIP	RGPD4 RGPD3	1.60e-03	11	103	2	PF01465
Domain	FYVE_2	RPH3AL RPH3A	1.60e-03	11	103	2	PF02318
Domain	Ran_BP1	RGPD4 RGPD3	1.92e-03	12	103	2	PF00638
Domain	RANBD1	RGPD4 RGPD3	1.92e-03	12	103	2	PS50196
Domain	RABBD	RPH3AL RPH3A	1.92e-03	12	103	2	PS50916
Domain	GRIP_dom	RGPD4 RGPD3	1.92e-03	12	103	2	IPR000237
Domain	GRIP	RGPD4 RGPD3	1.92e-03	12	103	2	PS50913
Domain	Rab_BD	RPH3AL RPH3A	1.92e-03	12	103	2	IPR010911
Domain	RanBD	RGPD4 RGPD3	2.26e-03	13	103	2	SM00160
Domain	Ran_bind_dom	RGPD4 RGPD3	2.26e-03	13	103	2	IPR000156
Domain	CYTOCHROME_B5_2	CYB5D2 HERC2	2.26e-03	13	103	2	PS50255
Domain	CYTOCHROME_B5_1	CYB5D2 HERC2	2.26e-03	13	103	2	PS00191
Domain	Cyt-b5	CYB5D2 HERC2	2.62e-03	14	103	2	PF00173
Domain	-	CYB5D2 HERC2	2.62e-03	14	103	2	3.10.120.10
Domain	MORN	RSPH10B MORN3	2.62e-03	14	103	2	SM00698
Domain	Ldl_recept_b	LRP8 LRP5	2.62e-03	14	103	2	PF00058
Domain	LDLRB	LRP8 LRP5	2.62e-03	14	103	2	PS51120
Domain	Cyt_B5-like_heme/steroid-bd	CYB5D2 HERC2	2.62e-03	14	103	2	IPR001199
Domain	Cyt-b5	CYB5D2 HERC2	2.62e-03	14	103	2	SM01117
Domain	MORN	RSPH10B MORN3	3.02e-03	15	103	2	IPR003409
Domain	LY	LRP8 LRP5	3.02e-03	15	103	2	SM00135
Domain	MORN	RSPH10B MORN3	3.02e-03	15	103	2	PF02493
Domain	LDLR_classB_rpt	LRP8 LRP5	3.02e-03	15	103	2	IPR000033
Domain	Ion_trans_dom	NALCN SCN2A SCN3A SCN9A	3.66e-03	114	103	4	IPR005821
Domain	Ion_trans	NALCN SCN2A SCN3A SCN9A	3.66e-03	114	103	4	PF00520
Domain	UIM	ANKRD13D ANKRD13A	4.35e-03	18	103	2	PF02809
Domain	GPCR_2_secretin-like	FZD6 ADGRG7 ADGRF1	4.44e-03	60	103	3	IPR000832
Domain	GPCR_2-like	FZD6 ADGRG7 ADGRF1	4.44e-03	60	103	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	FZD6 ADGRG7 ADGRF1	4.65e-03	61	103	3	PS50261
Domain	Fibrinogen_CS	ANGPTL4 FGB	4.84e-03	19	103	2	IPR020837
Domain	Apc4_WD40_dom	EML6 EML5	5.36e-03	20	103	2	IPR024977
Domain	ANAPC4_WD40	EML6 EML5	5.36e-03	20	103	2	PF12894
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	CACNG6 SCN2A SCN3A SCN9A	1.61e-05	32	68	4	M27455
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN3A SCN9A	2.67e-08	3	105	3	19284629
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN2A SCN3A SCN9A	2.66e-07	5	105	3	8812438
Pubmed	Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.	GRIA1 GRIK2 GRIK3	2.66e-07	5	105	3	9466455
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	TPP2 MYCBP2 RBP1 TRRAP ANKRD13A CIAO1 SMN1 HERC2	2.81e-07	212	105	8	33853758
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN2A SCN3A SCN9A	5.31e-07	6	105	3	23652591
Pubmed	Glutamate receptors in cortical plasticity: molecular and cellular biology.	GRIA1 GRIK2 GRIK3	9.28e-07	7	105	3	9016303
Pubmed	Glutamate receptors: brain function and signal transduction.	GRIA1 GRIK2 GRIK3	9.28e-07	7	105	3	9651535
Pubmed	Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate.	GRIA1 GRIK2 GRIK3	9.28e-07	7	105	3	1310861
Pubmed	Transmembrane topology of the glutamate receptor subunit GluR6.	GRIA1 GRIK2 GRIK3	1.48e-06	8	105	3	8163463
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN2A SCN3A SCN9A	2.22e-06	9	105	3	16382098
Pubmed	Expression of glutamate receptor subunit genes during development of the mouse retina.	GRIA1 GRIK2 GRIK3	2.22e-06	9	105	3	9051806
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN2A SCN3A SCN9A	7.48e-06	13	105	3	15123669
Pubmed	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	GRIA1 GRIK2 GRIK3	7.48e-06	13	105	3	20859245
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	RGPD4 MYCBP2 UFC1 GRIA1 CNKSR2 DBI NDRG3 RPH3A YTHDF1 ELFN1 RAB3GAP2 RGPD3 CPNE4 GFM1	8.65e-06	1139	105	14	36417873
Pubmed	Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.	SCN2A SCN3A	9.03e-06	2	105	2	20346423
Pubmed	Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.	SCN2A SCN3A	9.03e-06	2	105	2	11245985
Pubmed	GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.	GRIK2 GRIK3	9.03e-06	2	105	2	17620617
Pubmed	N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.	YTHDF1 YTHDF2	9.03e-06	2	105	2	26046440
Pubmed	Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.	SCN2A SCN3A	9.03e-06	2	105	2	23016767
Pubmed	Atypical functional properties of GluK3-containing kainate receptors.	GRIK2 GRIK3	9.03e-06	2	105	2	20007474
Pubmed	Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.	SCN2A SCN3A	9.03e-06	2	105	2	27153334
Pubmed	Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.	SCN3A SCN9A	9.03e-06	2	105	2	25172946
Pubmed	Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.	GRIK2 GRIK3	9.03e-06	2	105	2	15094479
Pubmed	[Regulation of 2-methoxyestradiol-induced cell apoptosis by mcl-1 and bax genes in myelodysplastic syndrome].	CASP3 MCL1	9.03e-06	2	105	2	19840460
Pubmed	The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-alpha-expressing cells through caspase-3-mediated cleavage of Mcl-1.	CASP3 MCL1	9.03e-06	2	105	2	17495975
Pubmed	HBx sensitizes cells to oxidative stress-induced apoptosis by accelerating the loss of Mcl-1 protein via caspase-3 cascade.	CASP3 MCL1	9.03e-06	2	105	2	21504623
Pubmed	Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma.	RPH3AL RPH3A	9.03e-06	2	105	2	17981610
Pubmed	Cineromycin B isolated from Streptomyces cinerochromogenes inhibits adipocyte differentiation of 3T3-L1 cells via Krüppel-like factors 2 and 3.	KLF3 KLF2	9.03e-06	2	105	2	26092481
Pubmed	YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer.	YTHDF1 YTHDF2	9.03e-06	2	105	2	34408926
Pubmed	The mechanism underlying redundant functions of the YTHDF proteins.	YTHDF1 YTHDF2	9.03e-06	2	105	2	36694229
Pubmed	Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.	SVEP1 ANGPTL4	9.03e-06	2	105	2	26934567
Pubmed	The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer.	USP13 MCL1	9.03e-06	2	105	2	33627786
Pubmed	Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors.	USP13 MCL1	9.03e-06	2	105	2	29335437
Pubmed	Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor.	GRIA1 GRIK2 GRIK3	1.18e-05	15	105	3	22241839
Pubmed	YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation.	YTHDF1 YTHDF2	2.70e-05	3	105	2	35508130
Pubmed	Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).	SCN3A SCN9A	2.70e-05	3	105	2	33895391
Pubmed	A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA.	YTHDF1 YTHDF2	2.70e-05	3	105	2	32492408
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN2A SCN3A	2.70e-05	3	105	2	23859570
Pubmed	Expression of G protein αq Subunit is Decreased in Lymphocytes from Patients with Rheumatoid Arthritis and is Correlated with Disease Activity.	CASP3 MCL1	2.70e-05	3	105	2	21923740
Pubmed	Inhibition of Myeloid Cell Leukemia 1 and Activation of Caspases Are Critically Involved in Gallotannin-induced Apoptosis in Prostate Cancer Cells.	CASP3 MCL1	2.70e-05	3	105	2	26014377
Pubmed	The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain.	GRIK2 GRIK3	2.70e-05	3	105	2	31513786
Pubmed	Mouse model for molybdenum cofactor deficiency type B recapitulates the phenotype observed in molybdenum cofactor deficient patients.	CASP3 MOCS2	2.70e-05	3	105	2	27138983
Pubmed	Caspase cleavage of Mcl-1 impairs its anti-apoptotic activity and proteasomal degradation in non-small lung cancer cells.	CASP3 MCL1	2.70e-05	3	105	2	29256070
Pubmed	m6A-binding YTHDF proteins promote stress granule formation.	YTHDF1 YTHDF2	2.70e-05	3	105	2	32451507
Pubmed	The m6 A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.	YTHDF1 YTHDF2	2.70e-05	3	105	2	34643063
Pubmed	YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.	YTHDF1 YTHDF2	2.70e-05	3	105	2	28106072
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN2A SCN3A	2.70e-05	3	105	2	12610651
Pubmed	Extracellular 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-ζ chain down-regulation via caspase-3 activation in oral cancer.	CASP3 OAS2	2.70e-05	3	105	2	26595239
Pubmed	Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.	SCN3A SCN9A	2.70e-05	3	105	2	19699781
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN2A SCN3A	2.70e-05	3	105	2	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN2A SCN3A	2.70e-05	3	105	2	17544618
Pubmed	Coupling caspase cleavage and ubiquitin-proteasome-dependent degradation of SSRP1 during apoptosis.	CASP3 SSRP1	2.70e-05	3	105	2	16498457
Pubmed	m6A enhances the phase separation potential of mRNA.	YTHDF1 YTHDF2	2.70e-05	3	105	2	31292544
Pubmed	Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice.	GRIK2 GRIK3	2.70e-05	3	105	2	9880586
Pubmed	Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.	SCN2A SCN3A	2.70e-05	3	105	2	16052353
Pubmed	Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration.	YTHDF1 YTHDF2	2.70e-05	3	105	2	34497675
Pubmed	Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1.	CASP3 MCL1	2.70e-05	3	105	2	19942343
Pubmed	Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.	GRIK2 GRIK3	2.70e-05	3	105	2	32567721
Pubmed	Differential trafficking of GluR7 kainate receptor subunit splice variants.	GRIK2 GRIK3	2.70e-05	3	105	2	15805114
Pubmed	Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains.	GRIA1 GRIK2	2.70e-05	3	105	2	10358037
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN2A SCN3A	2.70e-05	3	105	2	14973256
Pubmed	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.	YTHDF1 YTHDF2	2.70e-05	3	105	2	27371828
Pubmed	Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.	GRIA1 GRIK2 GRIK3	4.53e-05	23	105	3	8464923
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIA1 GRIK2 GRIK3	5.17e-05	24	105	3	35746896
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN2A SCN3A	5.40e-05	4	105	2	17537961
Pubmed	Distribution of kainate receptor subunits at hippocampal mossy fiber synapses.	GRIK2 GRIK3	5.40e-05	4	105	2	12954862
Pubmed	Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients.	GRIA1 GRIK2	5.40e-05	4	105	2	19295509
Pubmed	The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis.	CASP3 MCL1	5.40e-05	4	105	2	33959612
Pubmed	Deregulated expression of Kruppel-like factors in acute myeloid leukemia.	KLF3 KLF2	5.40e-05	4	105	2	21470678
Pubmed	Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool.	GRIK2 GRIK3	5.40e-05	4	105	2	15513934
Pubmed	Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses.	GRIK2 GRIK3	5.40e-05	4	105	2	19369569
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN2A SCN3A	5.40e-05	4	105	2	35801810
Pubmed	Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8.	CASP3 MCL1	5.40e-05	4	105	2	14982947
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN2A SCN3A	5.40e-05	4	105	2	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN2A SCN3A	5.40e-05	4	105	2	29578003
Pubmed	Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens.	INPP5B GRIK3	5.40e-05	4	105	2	8530037
Pubmed	Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.	YTHDF1 YTHDF2	5.40e-05	4	105	2	26318451
Pubmed	Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events.	CASP3 MCL1	5.40e-05	4	105	2	15014070
Pubmed	Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice.	APOB DGAT2	5.40e-05	4	105	2	18252207
Pubmed	Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma.	CASP3 MCL1	5.40e-05	4	105	2	20038816
Pubmed	Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.	GRIK2 GRIK3	5.40e-05	4	105	2	30241548
Pubmed	N6-methyladenosine-dependent regulation of messenger RNA stability.	YTHDF1 YTHDF2	5.40e-05	4	105	2	24284625
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN2A SCN3A	5.40e-05	4	105	2	8974318
Pubmed	Developmental expression patterns of kainate receptors in the mouse spinal cord.	GRIK2 GRIK3	8.97e-05	5	105	2	23076118
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN2A SCN3A	8.97e-05	5	105	2	1679748
Pubmed	GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex.	CASP3 GRIA1	8.97e-05	5	105	2	10896157
Pubmed	Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation.	YTHDF1 YTHDF2	8.97e-05	5	105	2	32610122
Pubmed	Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells.	RPH3AL RPH3A	8.97e-05	5	105	2	14722103
Pubmed	Early development of electrical excitability in the mouse enteric nervous system.	SCN3A SCN9A	8.97e-05	5	105	2	22875929
Pubmed	Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborization.	CASP3 UNC5A	8.97e-05	5	105	2	20493932
Pubmed	Determination of kainate receptor subunit ratios in mouse brain using novel chimeric protein standards.	GRIK2 GRIK3	8.97e-05	5	105	2	26448475
Pubmed	Kainate receptors: pharmacology, function and therapeutic potential.	GRIK2 GRIK3	8.97e-05	5	105	2	18793656
Pubmed	Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death.	CASP3 MCL1	8.97e-05	5	105	2	20085765
Pubmed	Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.	GRIK2 GRIK3	8.97e-05	5	105	2	12223554
Pubmed	Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors.	GRIA1 GRIK2	8.97e-05	5	105	2	12573530
Pubmed	Molecular determinants of kainate receptor trafficking.	GRIK2 GRIK3	8.97e-05	5	105	2	18358623
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN2A SCN3A	8.97e-05	5	105	2	24337656
Pubmed	The Ankrd13 Family of Ubiquitin-interacting Motif-bearing Proteins Regulates Valosin-containing Protein/p97 Protein-mediated Lysosomal Trafficking of Caveolin 1.	ANKRD13D ANKRD13A	8.97e-05	5	105	2	26797118
Pubmed	Context-dependent functional compensation between Ythdf m6A reader proteins.	YTHDF1 YTHDF2	8.97e-05	5	105	2	32943573
Pubmed	Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.	GRIK2 GRIK3	8.97e-05	5	105	2	28228252
Cytoband	2q24	SCN3A SCN9A	2.81e-04	11	105	2	2q24
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN2A SCN3A SCN9A	4.59e-06	9	70	3	1203
GeneFamily	Glutamate ionotropic receptor kainate type subunits	GRIK2 GRIK3	1.47e-04	5	70	2	1199
GeneFamily	Lysozymes, c-type	LYZL1 LYZL2	5.23e-04	9	70	2	1174
GeneFamily	Low density lipoprotein receptors	LRP8 LRP5	1.12e-03	13	70	2	634
GeneFamily	Zinc fingers C2H2-type\|Kruppel like factors	KLF3 KLF2	2.17e-03	18	70	2	624
GeneFamily	Fibrinogen C domain containing	ANGPTL4 FGB	4.18e-03	25	70	2	554
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HSERT	MYCBP2 NAP1L3 GRIA1 GRIK2 SLC35F3 NALCN SCN2A SCN3A SCN9A CPNE4	1.36e-05	450	105	10	M39072
Coexpression	GSE12003_MIR223_KO_VS_WT_BM_PROGENITOR_4D_CULTURE_UP	LZTR1 MYCBP2 CHDH KLF3 TRRAP TMEM168 HERC1	1.64e-05	200	105	7	M387
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	MYCBP2 EML6 GRIA1 CNKSR2 GRIK2 SLC35F3 SCN2A SCN3A HERC1	1.08e-09	200	104	9	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PRUNE2 GRIK2 GRIK3 UNC5A EML5 SCN2A SCN3A	2.59e-07	184	104	7	571136c832cb8c08457744152231537aa8e8abd7
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRUNE2 IL20RA GRIK2 SLC35F3 NALCN SCN2A SCN3A	3.00e-07	188	104	7	c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EML6 GRIA1 CNKSR2 GRIK2 SLC35F3 SCN2A SCN3A	3.98e-07	196	104	7	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-ILC\|Multiple_Sclerosis / Disease, condition lineage and cell class	USP13 RPH3AL CENPL INPP5B EML6 JMJD4 SCN9A	4.56e-07	200	104	7	ab9bdc9365cbdffe4ed246ce0c8a008a390e387e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EML6 APOB SLC35F3 SCN2A SCN3A ADGRF1	1.23e-06	146	104	6	e887e9de895fd453faa703997ef372cc6410fc49
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBP1 PKHD1L1 NALCN SCN3A SCN9A KLKB1	2.88e-06	169	104	6	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	ANKRD13D NDRG3 SCN2A CPNE4 HERC1 TECPR1	3.63e-06	176	104	6	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MID2 GRIA1 PKHD1L1 UNC5A NALCN SCN9A	3.75e-06	177	104	6	c274fbdc141855ff4581d437d4997c64cc193278
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MID2 GRIA1 PKHD1L1 UNC5A NALCN SCN9A	3.75e-06	177	104	6	f5e6df5cafd003bbfbb3b634ee58d0b1e2be5cc7
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MID2 GRIA1 PKHD1L1 UNC5A NALCN SCN9A	3.75e-06	177	104	6	c8a51e480b978dc0ded85583261f2c892e085be8
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GRIK2 GRIK3 EML5 SCN2A SCN3A CPNE4	4.01e-06	179	104	6	af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCell	3'_v3-Lung-Lymphocytic_B\|Lung / Manually curated celltypes from each tissue	CNKSR2 PKHD1L1 KLF2 TLR10 FCER2 SCN3A	4.14e-06	180	104	6	237a2130a3f48595dad2417539c21e44585962b8
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNKSR2 APOB GRIK3 PKHD1L1 SCN2A SCN9A	4.69e-06	184	104	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNKSR2 APOB GRIK3 PKHD1L1 SCN2A SCN9A	4.69e-06	184	104	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNKSR2 APOB GRIK3 PKHD1L1 SCN2A SCN9A	4.69e-06	184	104	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRUNE2 EML6 IL20RA GRIK2 SCN2A SCN3A	4.99e-06	186	104	6	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYCBP2 KLF2 TLR10 FCER2 SCN2A SCN3A	5.64e-06	190	104	6	a7498fe55b7810c482291db782dc5282675d246a
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-B_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PKHD1L1 KLF2 TLR10 ANKRD13A FCER2 SCN3A	5.99e-06	192	104	6	0bda96d8f223e8fa9caf935079ab202fc5c812ee
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNKSR2 SLC35F3 SCN2A SCN3A CCAR2 CPNE4	6.54e-06	195	104	6	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	USP13 RBP1 PKHD1L1 NALCN ADAMTS9 RSPH10B	6.54e-06	195	104	6	590c0dc0db4dc62879645ed7f61292ff97d2c7d5
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-memory_B_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYCBP2 PKHD1L1 KLF2 TLR10 ANKRD13A FCER2	6.94e-06	197	104	6	43e576bd6997915d21137e233e36984eba31f637
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EML6 GRIA1 CNKSR2 GRIK2 SCN2A SCN3A	7.14e-06	198	104	6	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EML6 GRIA1 CNKSR2 GRIK2 SCN2A SCN3A	7.14e-06	198	104	6	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	medial-Endothelial-Lymphatic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RBP1 PKHD1L1 UNC5A ADAMTS9 SCN3A SCN9A	7.14e-06	198	104	6	41983d405215b974044e2e9e6c212b134336a6fe
ToppCell	medial-2-Endothelial-Lymphatic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RBP1 PKHD1L1 UNC5A ADAMTS9 SCN3A SCN9A	7.14e-06	198	104	6	e4274584512a72270087a1ab104fab449a2f83bc
ToppCell	medial-Endothelial-Lymphatic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RBP1 PKHD1L1 UNC5A ADAMTS9 SCN3A SCN9A	7.14e-06	198	104	6	1760fede363544bc0fa2e22fe36aff522abd2525
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	C1orf167 KLF2 TLR10 FCER2 ANGPTL4	2.16e-05	143	104	5	091708a47ac55c6585923ee30190ff296fa87f6f
ToppCell	COVID-naiveBc-\|COVID / Condition, Cell_class and T cell subcluster	EML6 PKHD1L1 TLR10 FCER2 SCN3A	3.59e-05	159	104	5	4e6783b0f69c0c70150f9f3594881dc1bac7038a
ToppCell	COVID-naiveBc\|COVID / Condition, Cell_class and T cell subcluster	EML6 PKHD1L1 TLR10 FCER2 SCN3A	3.59e-05	159	104	5	52cd36b4412f69a935b3f76da96c166a9481eb0c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRIA1 GRIK2 RPH3A SCN9A GPR156	3.81e-05	161	104	5	7d1bc73f4c82465b3f489d6737048b0cd54f22cf
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRIA1 GRIK2 RPH3A SCN9A GPR156	3.81e-05	161	104	5	410eef62c83c704cbfc5a1b643c4db11bbdcd81f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRIA1 GRIK2 RPH3A SCN9A GPR156	3.81e-05	161	104	5	71022485da6754a2b57b4c3e758e3de4c95cc292
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRIA1 GRIK2 RPH3A SCN9A GPR156	3.81e-05	161	104	5	59ae8a7c9a04ecaa335b8064852a5a91a21780bd
ToppCell	droplet-Heart-nan-18m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPL NAP1L3 ADAMTS9 DGAT2 ANGPTL4	4.67e-05	168	104	5	2201ae834b53cbdc085f8f02607fa5b5bd911268
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells\|GI_small-bowel / Manually curated celltypes from each tissue	KLF2 TLR10 ANKRD13A FCER2 SCN3A	4.67e-05	168	104	5	8e025bb0541746e232b77ac0e31412ae71420c47
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PKHD1L1 FZD6 UNC5A SCN9A LRP5	4.67e-05	168	104	5	a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B\|GI_small-bowel / Manually curated celltypes from each tissue	KLF2 TLR10 ANKRD13A FCER2 SCN3A	4.67e-05	168	104	5	5535c1b8b7fde7b59a1bc0580cebdfa963aa1c39
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	SH3D21 SLC5A11 SLC35F3 SCN9A LRP5	4.67e-05	168	104	5	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PKHD1L1 FZD6 UNC5A SCN9A LRP5	4.67e-05	168	104	5	dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	USP13 PKHD1L1 UNC5A NALCN SCN3A	5.36e-05	173	104	5	7dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-ILC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	USP13 RPH3AL CENPL JMJD4 SCN9A	5.51e-05	174	104	5	7c50bf9da37711266cc077eef4e54b58463f1d37
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma-4\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	RPH3AL IL20RA SVEP1 SCN9A HECA	5.66e-05	175	104	5	16849ea8f0985108baa2085f34c3de14a4f9f28b
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIA1 PKHD1L1 SKAP1 SCN3A CCAR2	5.66e-05	175	104	5	f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CNKSR2 EML5 SLC35F3 SCN2A CCAR2	5.98e-05	177	104	5	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-11\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PKHD1L1 EML5 FCER2 SCN3A ZNF197	5.98e-05	177	104	5	3535575686c9700ab72700aae6f2070ebbb50044
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PKHD1L1 UNC5A NALCN SCN3A KLKB1	6.30e-05	179	104	5	ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PKHD1L1 UNC5A NALCN SCN3A KLKB1	6.30e-05	179	104	5	35fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANKRD13D PKHD1L1 SH3D21 FZD6 UNC5A	6.64e-05	181	104	5	2c44c41b4e8a75ebdbaeb0c6cc5a03f17c44758c
ToppCell	wk_15-18-Epithelial-PNS-SST+_neuron\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PRUNE2 GRIK2 GRIK3 RPH3A EML5	6.82e-05	182	104	5	a7e77aaaddabf78c7784f72b3431703fc5ee4a8c
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 SLC17A3 CHDH SCN2A SKAP1	6.82e-05	182	104	5	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	mild-B_cell\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPH3AL PKHD1L1 SH3D21 FCER2 SCN3A	7.00e-05	183	104	5	175aaf8fbbff52eab87d78a49d5ab02cd489c438
ToppCell	Frontal_cortex-Neuronal-Excitatory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	LZTR1 MYCBP2 CNKSR2 NDRG3 SCN2A	7.18e-05	184	104	5	6e17c8151d6dc543de16d804db956c63c3fda414
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYCBP2 KMT2E KLF2 TLR10 FCER2	7.37e-05	185	104	5	e913c64f9b4873443d88dce270f0b7b6d1b4cbce
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	PKHD1L1 UNC5A ADAMTS9 SCN3A SCN9A	7.37e-05	185	104	5	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC35F3 SCN2A SKAP1 SCN3A ADGRF1	7.37e-05	185	104	5	3d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	PKHD1L1 UNC5A ADAMTS9 SCN3A SCN9A	7.37e-05	185	104	5	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBP1 GRIA1 SVEP1 SCN3A ANGPTL4	7.56e-05	186	104	5	ca5e9c6531cb5d199e27509bfab1d62e3937177e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 RPH3A SVEP1 SCN2A CCAR2	7.56e-05	186	104	5	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBP1 GRIA1 SVEP1 SCN3A ANGPTL4	7.56e-05	186	104	5	1ed71b229f40a680071b14f5a7a19706e0fd14b1
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PRUNE2 GRIK2 GRIK3 EML5 SCN3A	7.56e-05	186	104	5	2fdd0a80ad31cf017aafcf5dcf760ebd786b98c1
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RBP1 FZD6 ADAMTS9 LOXL2 CPNE4	7.56e-05	186	104	5	a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK2 GRIK3 LRP8 ADAMTS9 ELFN1	7.75e-05	187	104	5	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PRUNE2 GRIK2 SLC35F3 NALCN SCN3A	7.75e-05	187	104	5	98477ba04a42a8da80a72f41a182429f46283595
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RPH3AL EML6 SCN2A SCN3A ADGRF1	7.75e-05	187	104	5	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CNKSR2 GRIK2 GRIK3 SLC5A11 GPR156	7.95e-05	188	104	5	502045a39ffb1e92bd9499848368e8fa971edb88
ToppCell	COVID-19-lung-Lymphatic_EC\|lung / Disease (COVID-19 only), tissue and cell type	PKHD1L1 UNC5A ADAMTS9 SCN3A SCN9A	8.15e-05	189	104	5	c8db9aaf54ea3cc96c4a2f777c3389e0f31f67f3
ToppCell	Globus_pallidus-Endothelial\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	KLF2 FZD6 SAMD9L LOXL2 ANGPTL4	8.15e-05	189	104	5	ad7dc9d25edd68fb624380a082c389fe7d640e7d
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PKHD1L1 KLF2 NALCN ADAMTS9 SCN3A	8.15e-05	189	104	5	55a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK3 LRP8 ADAMTS9 ELFN1 SCN9A	8.35e-05	190	104	5	26843ec1d19ac85a50990705353b802745d33e4d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MID2 GRIA1 PKHD1L1 UNC5A SCN9A	8.35e-05	190	104	5	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PRUNE2 GRIK2 SLC35F3 NALCN SCN3A	8.35e-05	190	104	5	2375e604eacd38f61f3e661ba2f76d286fcceca7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MID2 GRIA1 PKHD1L1 UNC5A SCN9A	8.35e-05	190	104	5	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MID2 GRIA1 PKHD1L1 UNC5A SCN9A	8.35e-05	190	104	5	09a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PRUNE2 UNC5A EML5 SCN3A SCN9A	8.56e-05	191	104	5	3a5081dc542ac6262acfe5f8084a86616fee8082
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP3 KLF3 APOB ADGRG7 SAMD9L	8.56e-05	191	104	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RBP1 GRIA1 SVEP1 SCN3A ANGPTL4	8.56e-05	191	104	5	cd497abed9e00e4e0becd9dbc036c6e7a60ae791
ToppCell	wk_20-22-Endothelial-Lymph_endothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	RBP1 PKHD1L1 UNC5A SCN3A KLKB1	8.56e-05	191	104	5	631f95fd80dd3678b5b2ef201abf7fe646049af6
ToppCell	15-Trachea-Epithelial-Submucosal_gland_basal\|Trachea / Age, Tissue, Lineage and Cell class	CHDH RBP1 NALCN ADAMTS9 LOXL2	8.56e-05	191	104	5	409e12d2bb26b6d2ed025304ca6ace07df16638a
ToppCell	background-B_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	KLF2 TLR10 FCER2 SKAP1 FGB	8.56e-05	191	104	5	a189fdc9c739bb0801e2f38af0932a1ea615cb34
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP3 KLF3 APOB ADGRG7 SAMD9L	8.56e-05	191	104	5	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP3 KLF3 APOB ADGRG7 SAMD9L	8.56e-05	191	104	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRUNE2 IL20RA FZD6 ADAMTS9 LRP5	8.77e-05	192	104	5	8899d81306770adda893b5e146df1253971754c5
ToppCell	11.5-Airway-Epithelial-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	PRUNE2 GRIK3 EML5 SCN2A SCN3A	8.77e-05	192	104	5	a77d3692ff02ef7e066a9bd9e22725055a25c4d4
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RBP1 PKHD1L1 FZD6 NALCN KLKB1	8.77e-05	192	104	5	5388f3115ab285f3f3001af1d71543ed64b9e044
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRUNE2 IL20RA FZD6 ADAMTS9 LRP5	8.77e-05	192	104	5	5fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCell	droplet-Lung-30m-Mesenchymal\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RBP1 GRIA1 SVEP1 SCN3A ANGPTL4	8.77e-05	192	104	5	5d5bec238b196f0b3e727fd94f078d6ae524cb01
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RBP1 GRIA1 SVEP1 SCN3A ANGPTL4	8.77e-05	192	104	5	ff4b728a55c2550c806c47e9ae3d057c35df8464
ToppCell	Healthy/Control-B_intermediate\|World / Disease group and Cell class	EML6 CNKSR2 TLR10 FCER2 LRP5	8.77e-05	192	104	5	2266aa695955f5d885708e6bc0d5a8827c306223
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RBP1 GRIA1 SVEP1 SCN3A ANGPTL4	8.77e-05	192	104	5	2d3790bd80a7f214b37094121a2a86ff16362569
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK2 GRIK3 LRP8 ELFN1 SCN9A	8.77e-05	192	104	5	dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RBP1 PKHD1L1 FZD6 NALCN KLKB1	8.99e-05	193	104	5	ef007b736da56529ec628fc3df86a335e7ec3f18
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYCBP2 KLF2 TLR10 ANKRD13A FCER2	9.21e-05	194	104	5	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	Mild/Remission-B_activate-7\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MYCBP2 OAS2 KLF2 SAMD9L FCER2	9.21e-05	194	104	5	01c97543972159a9468272da06e7e611e2c21fae
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PKHD1L1 TLR10 ANKRD13A FCER2 SCN3A	9.21e-05	194	104	5	cbc4b6422777117e4123804168c23f19d1b79486
ToppCell	distal-2-Endothelial-Lymphatic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RBP1 PKHD1L1 UNC5A SCN3A SCN9A	9.44e-05	195	104	5	8e0f67a67af3bc0b16f48a621f74540f136383b7
ToppCell	distal-Endothelial-Lymphatic-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PKHD1L1 UNC5A ADAMTS9 SCN3A SCN9A	9.44e-05	195	104	5	f45c1349932ee7eb419cced8a4fdedae3610953f
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	MCL1 KLF3 OAS2 KMT2E SAMD9L	9.90e-05	197	104	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIA1 CNKSR2 GRIK2 SCN2A SCN3A	1.01e-04	198	104	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Bronchus_Control_(B.)-Immune-TX-B_cells\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	MYCBP2 KMT2E PKHD1L1 KLF2 FCER2	1.01e-04	198	104	5	6231c44a909dd06f85c8210814e976a5f29148d0
Drug	LY339434	GRIA1 GRIK2 GRIK3 FCER2	5.09e-08	9	104	4	CID006324635
Drug	Scorpion Venoms	CASP3 SCN2A SCN3A SCN9A	1.20e-06	18	104	4	ctd:D012604
Drug	NS 102	GRIA1 GRIK2 GRIK3 FCER2	2.82e-06	22	104	4	CID005282252
Drug	acetochlor	CASP3 MCL1 APOB FGB KLKB1	1.20e-05	65	104	5	ctd:C043377
Drug	lamotrigine	GRIA1 CACNG6 LOXL2 SCN2A SCN3A SCN9A	1.55e-05	116	104	6	CID000003878
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN2A SCN3A SCN9A	4.59e-06	10	101	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN2A SCN3A SCN9A	4.59e-06	10	101	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN2A SCN3A SCN9A	8.37e-06	12	101	3	DOID:0060170 (implicated_via_orthology)
Disease	anxiety disorder (implicated_via_orthology)	SCN2A SCN3A SCN9A	5.72e-05	22	101	3	DOID:2030 (implicated_via_orthology)
Disease	Psychosexual Disorders	GRIA1 GRIK2	1.72e-04	6	101	2	C0033953
Disease	Hypoactive Sexual Desire Disorder	GRIA1 GRIK2	1.72e-04	6	101	2	C0020594
Disease	Sexual Arousal Disorder	GRIA1 GRIK2	1.72e-04	6	101	2	C0036902
Disease	Frigidity	GRIA1 GRIK2	1.72e-04	6	101	2	C0016722
Disease	Orgasmic Disorder	GRIA1 GRIK2	1.72e-04	6	101	2	C0029261
Disease	clinical treatment	MYCBP2 CHDH APOB	3.78e-04	41	101	3	EFO_0007056
Disease	coronary artery disease (is_implicated_in)	APOB C1orf167 LRP8 FGB	3.94e-04	100	101	4	DOID:3393 (is_implicated_in)
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN2A SCN9A	4.11e-04	9	101	2	C3502809
Disease	endometrial carcinoma, endometriosis	TLR10 SKAP1	6.25e-04	11	101	2	EFO_0001065, EFO_1001512
Disease	peptidyl-glycine alpha-amidating monooxygenase measurement	MYCBP2 KLKB1	6.25e-04	11	101	2	EFO_0801871
Disease	Infantile Severe Myoclonic Epilepsy	SCN2A SCN9A	8.83e-04	13	101	2	C0751122
Disease	middle temporal gyrus volume measurement, Alzheimer's disease biomarker measurement	MYCBP2 CNKSR2	8.83e-04	13	101	2	EFO_0006514, EFO_0010316
Disease	phenylalanine measurement	SLC17A3 FGB KLKB1	8.97e-04	55	101	3	EFO_0005001
Disease	early cardiac repolarization measurement	MYCBP2 LRP5	1.03e-03	14	101	2	EFO_0004885
Disease	low density lipoprotein particle size measurement	AGPAT1 APOB ANGPTL4	1.05e-03	58	101	3	EFO_0008593
Disease	Hypertriglyceridemia	APOB ANGPTL4	1.18e-03	15	101	2	C0020557
Disease	emphysema imaging measurement	MYCBP2 CNKSR2 GRIK2 KLKB1	1.62e-03	146	101	4	EFO_0007626
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN2A HERC1	1.71e-03	18	101	2	HP_0002373
Disease	Autistic Disorder	LZTR1 GRIA1 GRIK2 KMT2E TRRAP	2.07e-03	261	101	5	C0004352
Disease	alpha-tocopherol measurement	RNF215 SCN3A	2.12e-03	20	101	2	EFO_0007898
Disease	cardiovascular system disease (is_implicated_in)	GYS1 FGB	2.33e-03	21	101	2	DOID:1287 (is_implicated_in)
Disease	disease of metabolism (implicated_via_orthology)	YTHDF1 YTHDF2	2.33e-03	21	101	2	DOID:0014667 (implicated_via_orthology)
Disease	proprotein convertase subtilisin/kexin type 9 measurement	CNKSR2 APOB	2.56e-03	22	101	2	EFO_0009312
Disease	carnosine measurement	GRIK2 KLKB1	3.05e-03	24	101	2	EFO_0010470
Disease	Dyslipidemias	APOB ANGPTL4	3.05e-03	24	101	2	C0242339
Disease	Dyslipoproteinemias	APOB ANGPTL4	3.05e-03	24	101	2	C0598784
Disease	lipoprotein measurement, phospholipid measurement	APOB RPH3A DGAT2	3.14e-03	85	101	3	EFO_0004639, EFO_0004732

Protein segments in the cluster

Peptide	Gene	Start	Entry
QTGIDLSGCTKWWRF	CCAR2	391	Q8N163
GSAVTAAGRWAFKKW	C1orf167	1401	Q5SNV9
RADCWLIEGDKGFVW	ELFN1	26	P0C7U0
RRDKNCAKSLSGGWW	ANGPTL4	336	Q9BY76
AFERNKCGIWGWRSE	ANKRD13D	241	Q6ZTN6
TYKRKDVCWLNWSNG	ADGRF1	726	Q5T601
WNLSAKDWDTYGCQK	ADGRG7	386	Q96K78
WRNSKDGSWFIQSLC	CASP3	206	P42574
LGLWKACTKRLWQAD	CACNG6	81	Q9BXT2
KVCIGLEWLWKFTGE	CHDH	361	Q8NE62
TKSGFWGWRTDKAEV	ANKRD13A	246	Q8IZ07
ALFNAASGWLGWKSK	RAB3GAP2	341	Q9H2M9
TCWYEGDWVQNIKKG	RSPH10B	201	P0C881
GDWVQNIKKGWGIRC	RSPH10B	206	P0C881
TCWYEGDWVQNIKKG	RSPH10B2	201	B2RC85
GDWVQNIKKGWGIRC	RSPH10B2	206	B2RC85
CAKGWIDWAASKLSG	NDRG3	166	Q9UGV2
KSSILGGQFAIWEKW	SLC17A3	101	O00476
KCTWEGCTWKFARSD	KLF3	291	P57682
WQGWKKHCEGRDLSE	LYZL1	126	Q6UWQ5
WQGWKKHCEGRDLSD	LYZL2	126	Q7Z4W2
KFATGQWTEWKIEGR	LZTR1	156	Q8N653
AWKFSGLDQCDGGWL	HAPLN2	281	Q9GZV7
KCKSRWDGSWHQLGT	HECA	461	Q9UBI9
ELKWKFISDGSVNGW	HERC2	3686	O95714
KRGLEWFVCDGWKFL	ATP9B	81	O43861
KEDSVKLWGSISGCW	HERC1	3646	Q15751
DGLACDWVGKKLYWT	LRP5	111	O75197
VLKNGEWGTVCDDKW	LOXL2	341	Q9Y4K0
RKQCSKEDGGGWWYN	FGB	421	P02675
DGDRFWWQKRGVFTK	EPX	646	P11678
WRTRFDLWNKTCSGG	CST9LP1	131	Q5W188
GRWNDAFCDRKLGAW	FCER2	266	P06734
SDGSNFGWETKIKAW	KMT2E	266	Q8IZD2
ICKFWKERWLVAGLS	GDPD4	86	Q6W3E5
EVKGAWQKLLWKFSG	OR2F1	296	Q13607
VSGDKICWQWLKKEA	OAS2	301	P29728
KSVWDLGWFVCKSSD	GPR151	101	Q8TDV0
WGTKCSKWAESGRFY	IL20RA	116	Q9UHF4
KGTERVWVWTACDFA	RGPD3	1421	A6NKT7
VFWVGSKKTCTEWAG	FZD6	491	O60353
KGSWKWACPRFSDEG	APOB	2926	P04114
WKSGDWSECLVTCGK	ADAMTS9	1056	Q9P2N4
NREGKVLWTGWFCCV	CENPL	151	Q8N0S6
LKCIVWDWDSNGKHD	CPNE4	226	Q96A23
SFSWSVNVCGRKKWL	JMJD4	241	Q9H9V9
TGKAKWDAWNELKGT	DBI	51	P07108
AWCDRILWKGKNITQ	INPP5B	601	P32019
TGGLASWEKLWARSK	GPR156	786	Q8NFN8
NCWVTGWGFSKEKGE	KLKB1	516	P03952
LDSKNAVCVWDWKRG	EML5	126	Q05BV3
LDAKNTVCIWDWRKG	EML6	126	Q6ZMW3
LKNKWWYDKGECGSG	GRIA1	776	P42261
EKWWRGNGCPEEESK	GRIK2	796	Q13002
KEKWWRGSGCPEEEN	GRIK3	796	Q13003
LERWKGELWDTCNIG	GYS1	126	P13807
KQVNWKACRWSSSGV	GFM1	26	Q96RP9
EEGSWGRWVQKKFQK	DGAT2	291	Q96PD7
WSDWGDQAKIEKSGL	LRP8	556	Q14114
TKRDWLVKQRGWDGF	MCL1	301	Q07820
ESLWKGWDRKAQRNG	MORN3	11	Q6PF18
CSEQREVWKRSGAWF	RPH3AL	141	Q9UNE2
RIVFAWWKGSKLDCN	RUSF1	146	Q96GQ5
REVWQWKEAKGGEIC	VARS2	216	Q5ST30
KGTERVWVWTACDFA	RGPD4	1421	Q7Z3J3
KCYRELGKNSEARWW	RMDN3	426	Q96TC7
QREVWKRSGAWFFKG	RPH3A	146	Q9Y2J0
LKSCFWKRLGWSESS	TEX14	1471	Q8IWB6
ARCSSWWGGLEIDSK	PRUNE2	651	Q8WUY3
SKTTEDKGWWEGECQ	SH3D21	96	A4FU49
EWPKDRRKCGLFWAN	TLR10	756	Q9BXR5
EESSTWKGNKECFWA	MOCS2	171	O96007
CVQKGEKEGRGWTQW	RBP1	96	P09455
IKWWLDGNKNCRSIT	SAMD9L	1131	Q8IVG5
GCDQRWKGGLSLNWK	PNPLA5	281	Q7Z6Z6
WKLTLWTTCGLSKDG	RNF215	216	Q9Y6U7
ESGKGKIWWNIRKTC	SCN9A	1171	Q15858
VQWWFKKFCKGDESL	SETMAR	386	Q53H47
FWKRTNEKGAFWGLI	SLC5A11	471	Q8WWX8
QWKVGDKCSAIWSED	SMN1	91	Q16637
NSWIELKKFSGSSGW	MYCBP2	2091	O75592
SWGWEIEDCKGCKID	NAP1L3	391	Q99457
EGKGKIWWNLRKTCY	SCN3A	1186	Q9NY46
RLWCSQKSGGVSRDW	CYB5D2	186	Q8WUJ1
LVGDSSWTCQKSGKW	SVEP1	2296	Q4LDE5
WTCSRAQLKKIFWGV	SLC35F3	56	Q8IY50
DLCVKGWNWGTVKFG	SSRP1	101	Q08945
RIWGTEGDSWICKSV	CIAO1	41	O76071
GDCEGWLWKKKDAKS	CNKSR2	571	Q8WXI2
LESNKEGTRWFGKCW	UFC1	56	Q9Y3C8
LVKGKDDTWKWGTSF	ZNF197	16	O14709
ELCIRTKWKGASVNW	MINDY4	736	Q4G0A6
KRELLWAGSAGLACW	AGPAT1	126	Q99943
GGFCEKLLLSDRWGW	TECPR1	81	Q7Z6L1
CCQISIEEGKGKLWW	SCN2A	1181	Q99250
GGKAIEFCIARWWAS	TPP2	726	P29144
IEWWREKNGSFCSRL	TMEM168	526	Q9H0V1
AGYAWNIKWRSTCGK	PKHD1L1	981	Q86WI1
WSLRLKKQSCEGSWE	UNC5A	531	Q6ZN44
EWIGKNASSWVFSRC	MID2	616	Q9UJV3
WAGLWQKRCKYSETA	TRRAP	2761	Q9Y4A5
SEWQKRWCVVSRGLF	SKAP1	126	Q86WV1
WLNLTDGSVLCGKWF	USP13	221	Q92995
TCAGVWSQDKWKGRF	YTHDF2	481	Q9Y5A9
SAGVWSQDKWKGKFD	YTHDF1	461	Q9BYJ9
WDGCGWKFARSDELT	KLF2	306	Q9Y5W3
SCGSEVKKWWTRQLT	NALCN	1711	Q8IZF0